GenomeNet

Database: Pfam
Entry: MCR_beta_N
LinkDB: MCR_beta_N
Original site: MCR_beta_N 
#=GF ID   MCR_beta_N
#=GF AC   PF02783.14
#=GF DE   Methyl-coenzyme M reductase beta subunit, N-terminal domain
#=GF AU   Mian N, Bateman A, Griffiths-Jones SR
#=GF SE   Pfam-B_2692 (release 5.2)
#=GF GA   21.80 21.80;
#=GF TC   22.80 106.50;
#=GF NC   20.40 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9367957
#=GF RT   Crystal structure of methyl-coenzyme M reductase: the key enzyme
#=GF RT   of biological methane formation 
#=GF RA   Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK; 
#=GF RL   Science 1997;278:1457-1462.
#=GF DR   INTERPRO; IPR022680;
#=GF DR   SCOP; 1mro; fa;
#=GF CC   Methyl-coenzyme M reductase (MCR) is the enzyme responsible for 
#=GF CC   microbial formation of methane. It is a hexamer composed of 2
#=GF CC   alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma
#=GF CC   (Pfam:PF02240) subunits with two identical nickel porphinoid
#=GF CC   active sites [1]. The N-terminal domain has an alpha/beta
#=GF CC   ferredoxin-like fold.
#=GF SQ   79
#=GS D1YVW2_METPS/6-187       AC D1YVW2.1
#=GS L0HAZ8_METFS/6-185       AC L0HAZ8.1
#=GS MCRB_METTH/6-187         AC O27236.3
#=GS A0A110A317_9EURY/6-185   AC A0A110A317.1
#=GS A0A101DP65_9EURY/1-81    AC A0A101DP65.1
#=GS F0TCV2_METLA/6-187       AC F0TCV2.1
#=GS A3CT50_METMJ/6-185       AC A3CT50.1
#=GS A0A126R0P5_9EURY/6-187   AC A0A126R0P5.1
#=GS U6EEC5_9EURY/6-187       AC U6EEC5.1
#=GS M4YU68_9EURY/6-186       AC M4YU68.1
#=GS J1L1E2_9EURY/6-186       AC J1L1E2.1
#=GS D5EAE0_METMS/3-184       AC D5EAE0.1
#=GS E3GZ55_METFV/6-187       AC E3GZ55.1
#=GS K4MLG8_9EURY/3-184       AC K4MLG8.1
#=GS A0A0Q1FFN5_9EURY/6-185   AC A0A0Q1FFN5.1
#=GS B8GE89_METPE/6-187       AC B8GE89.1
#=GS F4BXY4_METCG/3-184       AC F4BXY4.1
#=GS Q12TF4_METBU/3-184       AC Q12TF4.1
#=GS A0A166CF31_9EURY/6-187   AC A0A166CF31.1
#=GS A0A126R1Z6_9EURY/6-187   AC A0A126R1Z6.1
#=GS R9SMM9_9EURY/6-187       AC R9SMM9.1
#=GS A0A101ISD9_9EURY/6-185   AC A0A101ISD9.1
#=GS L0HFT2_METFS/6-187       AC L0HFT2.1
#=GS H1YXI3_9EURY/6-185       AC H1YXI3.1
#=GS A0A166B5S0_9EURY/6-187   AC A0A166B5S0.1
#=GS A0A139CST7_9EURY/3-184   AC A0A139CST7.1
#=GS A7I5U3_METB6/6-187       AC A7I5U3.1
#=GS A0A162FL39_9EURY/6-187   AC A0A162FL39.1
#=GS M9S9U8_9EURY/6-185       AC M9S9U8.1
#=GS D7DUH1_METV3/6-187       AC D7DUH1.1
#=GS A0A0A7LAU1_9EURY/6-185   AC A0A0A7LAU1.1
#=GS F0T8Q9_METLA/6-185       AC F0T8Q9.1
#=GS A0A0Q4BDK3_9EURY/6-187   AC A0A0Q4BDK3.1
#=GS D7E8Y1_METEZ/3-184       AC D7E8Y1.1
#=GS A0A0P9FZR9_9ARCH/5-198   AC A0A0P9FZR9.1
#=GS MCRB_METJA/9-190         AC Q58252.2
#=GS Q6LWZ9_METMP/6-187       AC Q6LWZ9.1
#=GS A6UWG8_META3/6-187       AC A6UWG8.1
#=GS A2SSC9_METLZ/6-186       AC A2SSC9.1
#=GS A0A0P9EET0_9ARCH/10-203  AC A0A0P9EET0.1
#=GS Q0W343_METAR/6-187       AC Q0W343.1
#=GS A2STS3_METLZ/6-186       AC A2STS3.1
#=GS D5VQV2_METIM/5-186       AC D5VQV2.1
#=GS J1L3J4_9EURY/6-187       AC J1L3J4.1
#=GS A0A101IW34_9EURY/6-186   AC A0A101IW34.1
#=GS A0A0Q4B8J1_9EURY/6-185   AC A0A0Q4B8J1.1
#=GS E1RDX8_METP4/6-185       AC E1RDX8.1
#=GS A5ULZ6_METS3/6-187       AC A5ULZ6.1
#=GS A5ULN2_METS3/6-187       AC A5ULN2.1
#=GS A3CSF8_METMJ/6-185       AC A3CSF8.1
#=GS A0A165ZC91_9EURY/6-187   AC A0A165ZC91.1
#=GS L0L0T9_METHD/3-184       AC L0L0T9.1
#=GS Q2NI03_METST/6-186       AC Q2NI03.1
#=GS MCRY_METJA/6-187         AC Q60390.2
#=GS U6ECJ3_9EURY/6-187       AC U6ECJ3.1
#=GS A0A166F251_9EURY/6-187   AC A0A166F251.1
#=GS F1SVF3_METKA/7-188       AC F1SVF3.1
#=GS A0B6N9_METTP/3-184       AC A0B6N9.1
#=GS Q8PXH4_METMA/3-184       AC Q8PXH4.1
#=GS Q2FSD8_METHJ/6-185       AC Q2FSD8.1
#=GS E1RJD7_METP4/6-187       AC E1RJD7.1
#=GS G7WN21_METH6/3-184       AC G7WN21.1
#=GS A0A125RDN9_9EURY/6-187   AC A0A125RDN9.1
#=GS I7LJY5_METBM/6-185       AC I7LJY5.1
#=GS A0A0N8W6N1_9EURY/6-184   AC A0A0N8W6N1.1
#=GS A0A150J848_9EURY/6-185   AC A0A150J848.1
#=GS I7LK61_METBM/6-185       AC I7LK61.1
#=GS A0A117KTG4_9EURY/1-179   AC A0A117KTG4.1
#=GS Q8THG7_METAC/3-184       AC Q8THG7.1
#=GS MCRB_METBF/3-184         AC P07955.3
#=GS MCRB_METBF/3-184         DR PDB; 1E6Y E; 5003-5184;
#=GS MCRB_METBF/3-184         DR PDB; 1E6Y B; 2003-2184;
#=GS MCRY_METFV/6-187         AC Q49171.1
#=GS A0A101IW50_9EURY/6-185   AC A0A101IW50.1
#=GS MCRY_METTH/6-187         AC P21111.4
#=GS F6D2D7_METPW/6-187       AC F6D2D7.1
#=GS R9T893_9EURY/6-186       AC R9T893.1
#=GS A0A0E3NTF4_9EURY/3-184   AC A0A0E3NTF4.1
#=GS F7XL10_METZD/3-184       AC F7XL10.1
#=GS D3E054_METRM/6-187       AC D3E054.1
#=GS A0A0P8AI73_9EURY/3-184   AC A0A0P8AI73.1
D1YVW2_METPS/6-187                  .DKIDLYDDKGKLLEKDVPLEAISPVINPAIRKIVNLTKRTVAVSLEGIESALKTG......K......VGGKGRQVLGRSLDLSIVKDADKIAKVVAD.TV.RI.NKSDDTAVKVIGGGKSLLVQVPTQRVEAGAEFVASLSCTASAVTEAIIDMYKVD....M....FDGPFVKNAVWGMYPQTMDLV.GGNVKMILEIPQKDEG......
L0HAZ8_METFS/6-185                  e-TIDLYSDDGKLLKSNVQLHRISPLLNPAARTIVDLTKRTINVNLAGIEEALKTA......R......LGK--GRIPGRELDLPIMEKKDELIAKIRE.MV.QV.EEGDDTGIQQFNGGKLLLVRAPTLRLSGASTYDAAITAVASAVTYAIVDTFDID....A....FNASTVKAAAWGSYPHTQDME.GALVTSILTIPQNNEG......
MCRB_METTH/6-187                    .DKVDLYDDRGNLVEEQVPLEALSPLRNPAIKSIVQGIKRTVAVNLEGIENALKTA......K......VGGPACKIMGRELDLDIVGNAESIAAAAKE.MI.QV.TEDDDTKVELLGGGKRALVQVPSARFDVAAEYSAAPLVTATAFVQAIINEFDVS....M....YDANMVKAAVLGRYPQSVEYM.GANIATMLDIPQKLEG......
A0A110A317_9EURY/6-185              .DKIDLYDDYGKRIAKDVPLEALSPLRNKAIQKIASLTKRTIGVSLAGIQNALATG......A......IAG--NIIQGKEIKADLVKDAEKLAKDIKE.MV.QV.VDGDDTVVNVIDEGKTLVVIVPQARTDAGIEYTTGFTSVAAAVTEAIITRYKVP....M....YKANMVKAAVWGKYPQTVNFV.GSNIKTILEVPQNNEG......
A0A101DP65_9EURY/1-81               h-------------------------------------------------------......-......------------------------------.--.--.------------GGKRALVQVPTTRFEAAAEYSVAPLVTASAFLQAIIKELDVS....M....YDANMVKAAILGRYPQSVEYL.GGNIATMLDIPQKLEG......
F0TCV2_METLA/6-187                  .DKIDLYGVNGKLLESDVPLEAVSPMVNPTIGKIVYDVKRSVAVNLAGIEKSLEKA......A......YGGKSNFIPGRELKLDLKGNVDVLSEKIEK.II.KI.DEDDDFNLKLINGGDQMLVQMPAQRINRAADYTVSTLVAGGAVVQAIIDTFDVD....K....FDASAVKTAVLGRYPQSVDFM.GANVSALLGPPVMLEG......
A3CT50_METMJ/6-185                  e-TIDLYDDAGKQLKSGVPLEKISPLVNPATRKLIDLTKRTIAVNLGGIQEGLKTG......K......VAK--GYVLGREMNLDIIGNKDAIIGKIKE.MV.QV.EEGDDTNIREFGGGKLILVEVPKTRLEAASTYDAAITSVASATTFSLVEQFDIG....A....FDAAMVKAAVWGGYPHTMDLT.GANVTSILSIPQNNEG......
A0A126R0P5_9EURY/6-187              .DKVDLYDDRGSLVEADVPIEALSPLRNPAIKDIISGVKRTVAVNLEGIEKSLKTA......S......VGGAKSKILGREIDLDVVGQADSIAASVKE.ML.QV.NEGDDTVSQVLSGGKRILVQIPTIRLDSSAEYSVATLATATALTQAIINEFDVD....M....YDANMVKAAILGRYPQSVEYM.GSNIKTMLDIPQKLEG......
U6EEC5_9EURY/6-187                  .DKVDLYDDRGNLVEAEVPIEALSPLRNPAIKSIVQGIKRTVAVNLEGTENALKAA......K......VGGPACKILGRELDLDIVGNAEAIAAKAKE.MI.QV.EEGDTTNVELLGGGKRALVQIPHTRFDAAAEYSAAPLVTANAFIQAIIDVCDVS....M....YDANMVKAAILGRYPQSVEYL.GGNIATMLDIPQKLEG......
M4YU68_9EURY/6-186                  .DVIDLYDDYGKRIAKGVPLEAISPLRNKAIQKIASLTKRTVVVSLAGIEKALKTG......A......VGG-NNWIAGKEIDAPIVADAEKLAKDIKA.MV.QV.TEDDGTQVIVKDGGKSLTVIVPEARTDAGIEYTTGFTTVAAATTEAIIDRYKVP....M....YKANMVKAAVWGRYPQTINFV.GSNIKSILEVPQNNEG......
J1L1E2_9EURY/6-186                  .DTIDLYDDEGKLLKSGVALEKVSPVVNPAIKKMMDLTKRTVAVNLAGIENGVKTG......A......VGGKANVIPGRTLDLSVVKDSDAIIAKIKD.MV.SV.VEGDDTVIKNF-GGKLLLVEVPKARIEAAATYDAAITSVAAATTYALIDQYNIG....P....FDAGIIKSAVWGTYPQTMDMA.GANVQSILSIPQNNEG......
D5EAE0_METMS/3-184                  .DKIDIYDDRGKLLESGVAIEELAPTRNAAIQRIIGDTKRTVAVNLGGIQKSLATG......K......MGGKARHMPGREMELDIVENAGAIADSVKE.FV.QV.DSDDDTNIETLGGGKQLLVQLPTARLTAGADYSSALTVSAAATVQTIVDMFNID....M....FNAPVVKGAVWGNYPQTMDMA.GGNIASILNIPQKNEG......
E3GZ55_METFV/6-187                  .DKVDLYDDRGNLVEEQVPIEALSPLRNTAIKKIIHDIKRTVAVNLEGIENALRSA......K......VGGSGCHIPGRELDVDVIDNAEAIAEKAKE.MI.QV.EEGDDTVVELLHDGKRALVKVPSSRLESAAEYSVAPLVTASAFIQSIIDVCDIS....I....YDANMVKAAVLGRYPQSVEYV.GGNIATMLDIPQKLEG......
K4MLG8_9EURY/3-184                  .DKIDIYDDRGKLLESGVDLMDIAPTRNAAIQNIIKDTKRTVAVNLAGIEKALESG......K......MGGLGRKILGRELKYDVVANASAIQDAVKG.FV.MA.KEGDDTNVKVLAGGKQLLVQVPSVRALVGADYVSASTVTGAAVVQAIIDMYKTD....M....FDAPIVKSAVWGSYPQTMDMM.GGNIASILSIPQNNEG......
A0A0Q1FFN5_9EURY/6-185              e-TIDLYDDQGKQLKSGVALDKISPLVNKGALEAIDLTKRTVAVNLAGIDNSIKTG......S......MGK--GRILGRAIKADCVKDADALSDAIAK.MV.SV.EDGDDTKITKVGGGKMLLVEVPSARLRAAATYDAATSAVAAAVTYALIEKYKVG....M....YDGAYVKSAVWGAYPQTMDMQ.GGNIVSILSIPQNNEG......
B8GE89_METPE/6-187                  e-TIDLYDDEGKLLKSGVNLEKISPLVNPGIKKIIDLTKRTIAVNLNGIQEGLKSG......K......LGGKANQILGRSLNYDIVKDHEAITERIKK.MI.EV.EEGDDTTIRTIGNGKMLMIEVPSARLASASTYDAAITSVASATTLALLDQYNIG....M....FDASVVKAAVWGTYPQTMDMQ.GANVVSILSIPQNNEG......
F4BXY4_METCG/3-184                  .DKIDLYSDRGVLLKSDVDLSAVSPLKNAAMQRLISLTKRTVAVNLAGVEGALKTG......K......VAGGRRQIKGRELNYDVVANAGALAEKIKT.LL.QV.APGDDTNVQILGGGKQLLVQVPTARVNAASEFVVGLTGAASATVEALIQQFKVG....I....VEAPMVHASVWGEYPQTVGMN.GGNVASVLNIPQNDEG......
Q12TF4_METBU/3-184                  .DKVDIYDDRGTLLESDVDILNLAPTTNTAIGKIIKDTKRTVAINLAGIEKGLATG......K......YGGKGRQILGRSLEYDIVGNADAIAESVAN.LV.KV.SNDDDTVVKVIGGGKQLLVQVPSARTDAGADFVSGSTVSGAAVVETIINTFNTD....M....FDAPLVKGAVWGSYPQTMDMS.GGNVASILSIPQQNEG......
A0A166CF31_9EURY/6-187              .DKVDLYDDRGNLVESNVPIEALSPLRNPAIKSIVSGVKRTVAVNLEGIQNSLRTA......A......VGGKACKILGRELDLDIVANADAIAASLKD.MI.KV.TDDDDTKVEPISGGKRILVQIPTARLESAAEYSVATLATSTALVQSLIKQFDIS....I....YDANMVKAAILGRYPQSVDYM.GSNIATMLDIPQKLEG......
A0A126R1Z6_9EURY/6-187              .DKIDLYDPNGKLLESDVPLEAISPMRNPAIENIIYNIKRSVAVNLSGIEKGLKNG......A......LGGKGRFIPGRELDLPITENAEIIGEKIRK.IV.RV.SDDDDISVSLINKGNQLLVQVPNERIKMAGDYTVSSLVTGAAVTQSIIDTFDVN....I....FDASTVKTAVMGAYPQTLDLS.GANISAILGPPVLFEG......
R9SMM9_9EURY/6-187                  .DKVDLYDDRGTLIDSDVPIEALSPVRNPAIKEITAGIKRTVAVNLEGIENSLRNA......A......VGTKASKILGRELDLDIVANVDAIAASVKK.MI.QV.TEDDDTVVEPLSGGKRLLVQVPTRRIDVAAEYSVATLATSTALTQAIVETCDVS....M....YDANMVKAAILGMYPQTVSYD.GSNIKTMLDVPQKLEG......
A0A101ISD9_9EURY/6-185              e-TIDLYDDAGKQLKSGVSLEKISPLVNPATRKLIDLTKRTIAVNLGGIQESLKTG......K......VAK--GYVLGREMNLDIVANKDAIIAKIKE.MV.QV.EEGDNTNIREFGGGKLILVEAPSARLEAASTYDAAITSVAAATTYALVEQFNIG....A....FDAAMVKAAVWGSYPHTMDLS.GANVTSILSIPQNNEG......
L0HFT2_METFS/6-187                  .DTIDLYDDEGKLLKSNVTIDKISPLVNKGTAGIIDLTKRTVAVNFAGIEEALKTG......K......FGGKSNQILGRSMSCSCVKDCDALAAKIKE.YV.QV.EAGDDTKITKVGGGKMILVEIPTARIRAAATYDCASTAVAAATTYALIEQYKVG....M....FDGAYVKGAVWGTYPQTMSMD.GGNVVTIMSIPQNNEG......
H1YXI3_9EURY/6-185                  .DTIDLYSDDGKLLKSGVELNKISPLVNPATLKLIDLTKRSIAVNLGGIEAALKSG......K......LGK-GGKILGRELDLPIMANKDAVIAKIKE.YV.DV.-EGEETTIREFKGGNLLLVEVPKARLNAASTYDASITAVAAATTYAIVDEFGVD....M....FDASAVKAATFGAYPHTMDME.GALVSSVLANPQNNEG......
A0A166B5S0_9EURY/6-187              .DTLDLYGPDGKLIEESAPLESISPLKNSAIRRMIFDIKRSSAVNLAGIEKGLRTG......A......MGGKSVYIPGRELDLPIVENAELIAEKIKR.II.QV.EEDDETNVELINGGQQLLVQLPHERLEVAADYTVSNLLAGSSVIQSIIDSFDIN....I....FDASTIKTAVMGAYPQTVDLG.GANISALLGPPVLLEG......
A0A139CST7_9EURY/3-184              .DKIDIYDDRGKLLESGVDLMDIAPTRNTAIQNIIKDTKRTVAVNLAGIEKALKTG......S......MGGAKKKILGRELDYDIVGNSGAIQDAVAD.LV.SV.DEGDDTNVKELGGGKQLLVQVPSVRSQVGADFVSASTVTGAAVVQTIIDMFNTD....M....FDAPIVKSAVWGSYPQTMDMS.GGNIASILSIPQKNEG......
A7I5U3_METB6/6-187                  .DTIDLYDDEGKLLKSNVTIDKISPLTNKGALELIDLTKRTVAVNLGGIEEALKTG......K......MGGKSNQILGRGLNYSIVKDADAISAKIKD.MI.QV.TDGDNTKITKIGGGKMLLVEVPSSRINASATYDATSTSVASATTYALIDQYKVN....M....FDGSYVKGAVWGTYPQTMDMQ.GGNVVSILSIPQNNEG......
A0A162FL39_9EURY/6-187              .DKVDLYDDRGNLVESDVPIEALSPLRNPAIKSIISGVKRTVAVNLEGIENSLRTA......A......VGGKACKILGRELDLDITANAEAIAASIKD.II.QV.TDDDDTVVDLLAGGKRILVQTPSVRLESAAEYSVSTLTTANALVQAIIKQFDVS....I....YDANMVKAAVLGRYPQSVDYM.GGNLATMLDIPQKLEG......
M9S9U8_9EURY/6-185                  .DVIDLYDDYGKRIAKDVPLEAISPLRNKAIQKIASLTKRTIAVNLAGIEKALATG......Q......IGG--SKIAGKEIEVPLVKDAKKLADDIKA.MV.QV.TEGDDTVVEVKNDGKLIVVIVPEDRLNAGVEYTTGFTAVAAAITEAIIDRYKVP....M....YKANMVKGAVWGQYPQTVNFA.GSNIKTILEVPQMNEG......
D7DUH1_METV3/6-187                  .DKICLFDAKGNQVAEDVPLEAISPLNNPTIMGMVKNIKRTVAVNLAGVEDSLAKG......K......IGGKGCQVPGRAIELDVVSDAEAIADKVKS.IL.QV.SAGDDTEVKLINGGKQMAVQVPTKRLDVAAEYSVSMLATGMALKEAIITNFNVD....M....FDGSTVHSAIMGQYPQDMDYA.GGNIASLLGAPSKLEG......
A0A0A7LAU1_9EURY/6-185              .DVVDLYDDNGKRIAKDVPLEAISPLRNNAIKKIASLTKRTVAVSLAGIEKGLKSG......A......VGG--SMIKGKEIDIELVKNAKKIAAAVKD.KV.QV.TADDGTVVTIKGDGKSLVVIVPAARTDAGVEYTTGFTAVAAAVTEAIIDEFKVP....M....YKANMVKAAVWGRYPQTVGFD.GANVKSILEIPQNNEG......
F0T8Q9_METLA/6-185                  .DKIDLYDDRGNLVEEQVPLEALSPLRNSAIKAIVQGVKRTVAVNLEGVENALKTG......K......LGG--GKILGRELDLDIVANAEAIAAKAAE.MI.QV.EEGDNTNVELLVGGKRALVQIPQARFDAGAEYSAGPLVTASAFIQSIIDVCDVS....M....YDANMVKAAILGRYPQSVDYM.GGNLATMLDVPQKLEG......
A0A0Q4BDK3_9EURY/6-187              .DVIDLYDDRGKRIAKDVPLEAISPLRNKAIKRIAAMTKRTVAVNLAGIEKSLKTG......V......IGGGGTQIRGKEIDIPLVKNAEKIAKAVKD.MV.QV.YDGDETIVEVKPGGKSLIVIAPEERLSAGVEYTTGFTVTAAATVQAIIDEFDIP....M....HKANMVKGAVWGRYPQTVGFT.GTNLRSILDVPQNNEG......
D7E8Y1_METEZ/3-184                  .DNIDLYNDRGKLLESNVDLMDIAPTKNDAIKKIIDDTKKSVAINLNGIQKALSTG......K......MGGKGRHIPGYELDYDLVGNADSIRDSVEE.LV.RV.DPNDDTNVESLYGGKQLLIQVPDERLQAGADYASATTVGAAATVQSIIDKFNTD....M....FVAPIVKAAVWGSYPQTVDLS.GGNIASILKIPQQNEG......
A0A0P9FZR9_9ARCH/5-198              .DAVDLYDDHSNCLAKDVPIQALSPLYNPYMGEVLDLFKRTAFVDLANLEKCMKLGrggwetR......IGRDEIQMPWYSRDLPIVERSEEIAKKMKEkMA.RY.GDGKEELVRLILGGKFIVVKIPERMMKISASRDPALTWTMVALCQAVAETFNLDpetdP....SGCNMLNAAVWGRYPQSPELPpGGPVFGFLKQS-----ntvdg.
MCRB_METJA/9-190                    .DTINLYDEKGKLVEENVPLEAISPLHNPTIQKLVKDVKRTVAVNLAGIENALRTG......Q......VGGKGCMIKGRELDLPIVENAETIAEYVEK.VV.RV.SEDDDTSIKLINDGKQMAVQIPSKRLDVAAEYSVSVLVTAQALKEAIIRTFDVD....I....FDAPMVHAAVLGGYPHEVTMK.GSNIAALLGSPLSLEG......
Q6LWZ9_METMP/6-187                  .DKISLYDAKGNLVAENVPLEAISPLYNPTIKSMVKNIKRTVAVNLAGIEGTLAAG......K......IGGKGCQVPGRTLDISAVSNAQAIADEVEK.IL.KV.SEDDDTAVKIINGGKQLAVQVPTARLDVAAEYSVSMLSTAMALKEALIKTFNID....M....FDGSTVHAAIVGNYPQVMDYA.GGNIASLLGAPSMMEG......
A6UWG8_META3/6-187                  .DKINLYDAKGNLAEENVPLEAISPLYNPVVKDMVKSIKRTVAVNLAGIEATLKAG......T......IGGKACRVPGRTLDLPIVDEAEAIMDKVEK.IL.KI.SEDDDTNIRTINGGKQAVVQVPSKRLDIAAEYSVSMLSTGMALKEAIIDTFDVD....M....FDGSTVHAAIVGRYPQVMDYM.GGNIASLLGAPSNMEG......
A2SSC9_METLZ/6-186                  .DVIDLYDDYGKLLRSNISLERISPLVNPAVKKIIDDTKRSVAVNLGGMQDGLKSG......K......IGK-HQQILGRELDLDILGNIDAIEAKIKE.YV.SV.ESGDDTEIKRFNGGKLLLVKVPSARIAAAATYDAALTSVAAATTYAVVEQFNVD....M....FNANTVKAAAFGTYPVTMDLA.GGACSMIMSIPQNNE-s.....
A0A0P9EET0_9ARCH/10-203             .DTLDLYDDHSNCIAKEVPLQALSPLYNPYMREVLNLFKRTAFIDLAKLEQYVKSG......RagwetvVGQDEIQMPWYGRDLPMVERSEEIAERIKE.KIaKF.DDGEEELVKPVAGGKLIIVKIPRRMMEVSASRDPPLTWTMVALCQAISETFNLN....PetdpDGCNMVRGAIFGRYPQSPELPpGGPVFGLLRQ------snivdg
Q0W343_METAR/6-187                  .DKIDLYDDKGKLLEKDVPLEAVSPIVNPAIRKIVNLTKRSVSVSLEGIENALKTG......K......VGGKGRQVLGKSLDLPLTKDADKIAKKIEE.LV.RV.TKGDDTNVKVLGGGKSLLVQVPTQRIEAGAEFVAGISSTATATVESILELYKVD....M....FDGAFVKAAVWGMYPQTIDLE.GGNVKSILDVPQKDEG......
A2STS3_METLZ/6-186                  .DVIDLYDDNGKLLKSNVALEKISPLVNPAIKKIIDDTKRTVAVNLGGMQDALKTG......K......IGK-HQQILGRELNLDIVGNIDAIEAKIKE.YV.SV.EAGDDTMIKRYNGGKLLLVKVPSARIAAAATYDAALTSVAAATTYAVVEQFNVD....M....FDANTVKAAAFGTYPVTMDLA.GGACSMIMSIPQNNE-s.....
D5VQV2_METIM/5-186                  .DTIDLYDEKGKLVEENVPLEAISPLYNPTIQKLVKDVKRTVAVNLAGIENALRTG......Q......VGGKGCKILGRELDLPIVENAETIAEYVEK.TL.RV.SEDDDTSIKLINDGKQMAVQVPSKRLDIAAEYTISTLVTAQALKEAIIRTFDVD....L....FDAPMIHAAILGGYPHDVTMK.GANISALLGNPLTLE-c.....
J1L3J4_9EURY/6-187                  e-TIDLYSDDGKLLKSGVTLDKISPLVNPATSKIIDLTKRTINVNLGGIQNALKTG......K......LGKGKSKIRGRELDLAIMENKDAIVARIKE.MV.QV.EEGDDTEILEFNNGQLLLVQVPKKRLMNAATYDAAITAVASATTYAIVDQFNID....A....FNASTVKAACWGGYPHTMDME.GALVSSILSIPQNNEG......
A0A101IW34_9EURY/6-186              .DTIDLYDDNGKLLKSNVALDKVSPLVNPAILKLVNLTKRTIAVNLGGIEAALKTG......K......IGK-HQQILGRELDLDIVKNADAITAKIQE.MV.QV.ADGDDTFINKYGGGKLLLVQAPTARLTAASTYDAAITAVASATTYAIMDQFNVG....M....FDANTVKAAVWGTYPQTMDMA.GAGVQSILSIPQNNEG......
A0A0Q4B8J1_9EURY/6-185              .DKIDLYDDKGKLIEKDVPLDAINPLYNPAIRRIASLAKRTIAVDLAGIEKGLKTG......R......VGG--GYIKGKEINADIVANADKIAKRVKD.IL.KV.DKDDDTEVRPILDGKRLVVHVPTARVDAGIEYTTGFTATAAAVTQAIIDEFGVD....M....FHANMVKTATWGRYPQTMNFL.GANVKSILEVPQNNEG......
E1RDX8_METP4/6-185                  e-TIDLYSDDGKVLKSNVNLGAISPLVNPATLKLIDLTKRSIAVNLGGIEAALKTG......K......LGK-GGMIMGRELDLPIMANKDAIVAKIKD.ML.DV.-EGEGTVINEYKGGNLLLVEAPKARLAAASTYDAAFTAVAAATTYAIVDQFDID....A....FNASTVKAATFGGYPHTMDPE.GALVTSVLSNPQNNEG......
A5ULZ6_METS3/6-187                  .DKVDLYDDRGSLVVSDVPIEALSPLRNTAIQNIVKGVKRTVAVNLEGLEKSVKTG......S......VGGDKSKILGRELDIDIVANAGAIAEKMKE.MI.QI.SEDDDTKVEPISGGKRLLVQVPSKRIDVAAEYSVAPLSTATSLVQAIIDVCDVS....I....YDANFVKAAVLGRCPQSVDYK.GSNIATMLDIPQKLEG......
A5ULN2_METS3/6-187                  .DKIDLYGQDGKLLKSEVSLDAISPLKNPAIAKMIFDIKRSCAVNLASIEKGLRTG......A......MGGKSVFIPGRELDLPIVENAELIADKIKR.IV.QV.NEDDATNVSLINNGQQLLIQLPNERLRVAADYSIASLLSGSATIQSIIDTFDIN....M....FDASTIKTAVMGAYPQTVDLA.GANISALLGPPVLLEG......
A3CSF8_METMJ/6-185                  e-TIDLYSDDGKLLKSGVALDRISPLVNPATGKIIDLTKRTISVNLGGIQDALKVG......K......LGK--GKIKGRELDLPIMENKDAIVAKIKE.MI.QV.EEGDDTEIMEFNGGKLLLVQVPTKRLVNASTYDAAITSVAAATTFSIVDQFNID....A....FNASTVKAACWGSYPHTQDME.GALVTSILTIPQNNEG......
A0A165ZC91_9EURY/6-187              .DKVDLYDDRGSEIASNVPIEALSPLRNPAIQNIVKGVKRTVAVNLEGLEKSVKTG......A......VGGDKSRILGRELDLDIVGNAEAIAEKMKE.II.QI.SESDDTKVELISGGKRLLVQVPTQRIDVAAEYSVAPLSTASALVQSVIEILDVD....I....YDANFVKAAVLGRYPQSVDYK.GSNIATMLDIPQKLEG......
L0L0T9_METHD/3-184                  .DKIDIYDDKGKLLESGVDLMDIAPTRNAAIQKIVKDTKRTVAVNLAGIENALASG......K......MGGAGRRILGRELKYDIVANASAIQDSVAK.LI.QV.NKDDDTNVQVLAGGKQLRVQVPSLRTAIGADYVSASTVGAAAVVQTIIDMYKVD....M....FDAPIVKGAVWGSYPQTMDMM.GSNVASILSIPQNNEG......
Q2NI03_METST/6-186                  .DKIDLYGVDGKLLEEQVPLEAISPVINPTIKNIIQEIKRSVAINLAGIEKSLANG......A......YGGKANFIPGRELELDIVDNADAIADKIEK.ML.KI.SDDDDFNLNLLNGGKQILVQVPSERLSIAGDYSVAPLATGSALIQAILDTFDIN....K....YQASEIKTAAMGGYPHNVKL-.GGALTTLLGQTTHLEG......
MCRY_METJA/6-187                    .DRIDLYDERGKLLEENVPLEAISPLKNPTIEKIVNDIKRSVAINLAGIENALKTG......A......VGGKACFCPGRELDLPIVENAEIIAEKIKR.MV.QI.EEDDDTVVKLINGGKQLLLQLPSKRLRVAADYTVSALIGGGATVQAIVDAFDVD....M....FDAPVVKTAVMGRYPQTVDFH.GANIATLLGPPVLLEG......
U6ECJ3_9EURY/6-187                  .DKIDLYGADGKLLESDVPLEAVSPMLNPTIENIVQTVKRSVAVNLAGIEKSLEKA......A......YGGKANFIPGRELKLPIVDNVDTIAAKIEK.MI.RV.DEEDDFNLKLINKGQQLLVQLPSQRMKMAGDYTVSTMVTGSAVVQAIIDTFDVD....K....FDASAIKTAVLGQYPQTVDFS.GANVSALLGPPQMLEG......
A0A166F251_9EURY/6-187              .DKVDLYDDRGSLVESNVPIEALSPLRNPAIKSIVSGVKRTVAVNLEGIENALRGA......T......VGGPACKILGRELDLNITGSADSIASSLKE.MI.QV.TEGDDTKVELLSGGKRILVQIPTARLDSAAEYSVATLSTATALVQALIKEFDIN....M....YDANMVKAAILGRYPQSVEYM.GGNIATMLDIPQKLEG......
F1SVF3_METKA/7-188                  .DTVDLYDDRGNCVAEEVPIEVLSPMRNEAIQSIVNDIKRTVAIDLEGIENALQNA......T......VGGKGMKIPGREMDVDIVDNAEAIADEIEK.MI.RV.YEDDDTNVEPMYDGKRLLVQLPSERVKVMADPYSGTLQAGMAVVHAIIDVCEVD....M....WDANMVKAAVFGRYPQTIDYF.GGNVASMLDVPMKQEG......
A0B6N9_METTP/3-184                  .DKIDIYSDRGVLLKSDVDLSAISPLRNAAIQKLAKLTRRTVAVNLAGIENALKTG......R......VGGGRRQIKGRELNYDIVANASALAEKIKA.LL.QV.TPGDDTNVQVLGGGKQLLVQIPSARAEIASEFVVGMTAAAAATVEAIIQHFKAG....L....FDAPMIHAAVWGEYPQTVGMN.GGNVASVLNIPQNDEG......
Q8PXH4_METMA/3-184                  .DTVDIYDDRGKLLESNVDIMSLAPTRNAAIKKIILDTKRSVAVNLAGIQGALASG......K......MGGKGRQILGRGLNYDIVGNVDAIAANVKK.LV.QV.DEGDDTNVRVLKGGKSLLIQAPSSRMAAGADFMAATTVGAAAVTQTLIDMFKTD....L....YDAPIVKSAVWGSYPQTMDLM.GGQVQGILSIPQNNEG......
Q2FSD8_METHJ/6-185                  .DTIDLYDDQGKLLKSGVALDKVSPLTNAGIKKMISLTKRTVAVNLGGAEAFLKTG......K......AGK--NQIPGRELNLDLVANAGAIKEKMFK.ML.QV.TEGDDTEIKEFGGGKLLLCTVPTARIEAAATYDAAMTAVSAAATYAVIDQFNVD....M....FNGSTVKAAFWGTYPQTMDPS.GSACASILSIPQNNEG......
E1RJD7_METP4/6-187                  .DTIDLYSDDGKLLKSDVNLRQISPMINPAAGKIIDLTKRTINVNLGGIETALKTG......R......LGKHKSRIRGRELDLPIMENKDALVEKIRS.MI.QI.EDDDDTEILEFNNGNLLLVQVPSKRLINAATYDAAITSVASATTYAIVDHFDIG....A....FDASVVKAACWGAYPQTMDME.ASLVTSILSIPQNNEG......
G7WN21_METH6/3-184                  .DKIDLYSDRGVLLKSDVDLSAVSPLKNAAMKKLINLTKRTVAVNLAGIENALKTG......K......VGGQGRQIKGRELKYDVVANANALAAEIKK.LL.QV.EAGDDTNVQVLGGGKQLLVQIPTARVDAASEFVVGMTATAAATCEALVTQFKAG....M....FEAPMVHAAVWGQYPQTVPMA.GGNIASVLNIPQNDEG......
A0A125RDN9_9EURY/6-187              .DKIDLFDDRGNEIASDVPIEAISPLRNPAIQKIVKGVKRTVAVNLEGLEKSVKTG......A......VGGDKSRILGRELDLAIVDNAEAIADKMKG.II.QV.SEDDDTVVTPISGGKRLLVQVPTKRIDVGAEYSAAPLSTASALVQSVIDICDVD....I....YDANFVKAAVLGRYPQSVDYK.GSNIATMLDIPQKLEG......
I7LJY5_METBM/6-185                  e-TIDLYSDDGKLLKSGVSLDRISPLVNPATSKIIDLTKRTINVNLGGIQDALKNG......K......LGQ--GKIKGRELDLPIMENKDAIVAKIKE.MI.QV.EEGDDTEILEFNGGKLQLVQVPAKRLINAATYDAAITAVASATTYAIVDQFNVD....A....FNASTVKAACWGGYPHTQDMK.GSLVTSILNIPQNNEG......
A0A0N8W6N1_9EURY/6-184              e-TIDLYDDTGKLLKSGVTLEKISPLVNPATKKLIDLTKRTIAVQLGKIESELKVG......K......VGK--GQIMGRELDLDIMGNKDAIVAKIKD.MV.DV.-EGGDTIVHEFSGGKLLLVEVPKARIDAAATYDAAITSVAAATTYSIIDQFNID....A....FNGSMVKAAAWGGYPHTMDLE.GALVSSVLTIPQNNEG......
A0A150J848_9EURY/6-185              .DKIDLYSDRGKLIESGVPLEALSPLKNEAIQSIVSKIVRTIAVDLKGTQSALATG......A......LGGKGQVIMGREMKLDVVGKAPEIKKRVEE.IL.KV.DAKDDTLVTLLGNNERMLVQVPTKRMF--CEYTVGMTATASAVTQAIIDVFDVS....I....FDANVIKAAIWGSYPQTLDLK.GAKIQAMLEVPQKNEG......
I7LK61_METBM/6-185                  .DTIDLYDDAGKLLKSGVPLDKISPLVNPATRKIIDLTKRTIAVNLGGIQDALKTG......K......VGK--GHVLGREMDLDIVGNKDAVIGKIKE.MV.QV.QEGDDTKIREFSGGKLFLVEVPSARLEAASTYDAAITSVAAATTYAIVEQFDVG....P....FDAAMVKGAVWGAYPHTMDMK.GALVTSILNIPQNNEG......
A0A117KTG4_9EURY/1-179              .--MDIYSDRGKLLASDVDIMDLAPTRNRAIRTIIHDTKRTAAVNLGGIEKALANG......R......IGK-VKKIPGKEMKLDIVANAERLAERVKE.LV.QV.NEGDDTTVEVLAGGKFLKVQVPSARLESGAEYVSSITASAAAITQAIIELFDVG....I....FDACMVKAAVWGDYPQTIGLN.GGNVSSILEIPQKDEG......
Q8THG7_METAC/3-184                  .DTVDIYDDRGKLLESNVDIMSLAPTRNAAIKKIILDTKRSVAVSLAGIQGALASG......K......MGGKGRQILGRGLNYDLVGNADAIAENVKN.LV.QV.DEGDDTSVKVIKGGKSLLIQAPSSRIAAGADYMSATTVGAAAVTQTIIDMFGTD....M....YDAPIAKSAVWGSYPQTMDLM.GGNVQGVLSIPQNNEG......
MCRB_METBF/3-184                    .DTVDIYDDRGKLLESNVDIMSLAPTRNAAIQSIIMDTKRSVAVNLAGIQGALASG......K......MGGKGRQILGRGLNYDIVGNADAIAENVKK.LV.QV.DEGDDTNVIKVKGGKSLLIQSPKSRIIAGADFMSATTVGAAAVTQTIMDMFGTD....P....YDAPIVKSAVWGSYPQTMDLM.GGQVQGILSIPQNNEG......
#=GR MCRB_METBF/3-184         SS    .-EEEEE-TTS-EEEEEEEGGGGSTTT-HHHHHHHHHHHHEEEEEHHHHHHHHHH-......-......-SSTT---TT------TGGGHHHHHHHHHH.HH.-S.STTSS-EEEEECCCTEEEEE--HHHHHTSSSSTHHHHHHHHHHHHHHHHHTT--....G....GGHHHHHHHHHTTTTTSSS-T.T-SEE-SS--GGG-SS......
MCRY_METFV/6-187                    .DKIDLYDANGKLLDENVPLEAISPLKNPTIGKIVNDVKRSVAVNLAGIENSLKKA......A......LGGKANFIPGRELDLDIVENAEIIAEKIKK.MV.QV.DENDDTNVKMINNGQQLLVQVPTIRIERAADYTVSTLVAGAATIQAIIDTFDVD....M....FDASTVKTAVLGRYPQTVDFT.GANVAAMLSPPVLLEG......
A0A101IW50_9EURY/6-185              e-TIDLYSDDGKLLKSGVTLDRISPLVNPATGKIIDLTKRTINVNLGGIQDALKAG......K......LGK--GKIKGRELDLPIMENKDAIVARIKE.MI.QV.EEGDDTEIMEFNGGKLQLVKVPTKRLVNASTYDAAITSVAAATTFAIVDQFNID....A....FNASTVKAACWGGYPHTQDME.GALVTSILTIPQNNEG......
MCRY_METTH/6-187                    .DRIDLYGADGKLLEEDVPLEAVSPLKNPTIANLVSDVKRSVAVNLAGIEGSLKKA......A......LGGKSNFIPGREVELPIVENAEAIAEKVKR.LV.QT.SEDDDTNIRLINNGQQILVQVPTTRMGVAADYTVSALVTGAAVVQAIIDEFDVD....M....FDANAVKTAVMGRYPQTVDFT.GANLSTLLGPPVLLEG......
F6D2D7_METPW/6-187                  .DKIDLYDDRGNLVEEQVPLEALSPLRNPAIKGIIQGVKRTVAVNLEGTENTLRNA......T......VGGKACKILGRELDLDLVGNAEAIAEKAKE.II.QV.EETDNTNVKLLAGGKRVLVQIPTVRFDAAAEYSAAASVTASAFIQAIIDVCDVS....M....YDANMVKAAILGRYPQTVDYM.GGNLATMLDVPQKLEG......
R9T893_9EURY/6-186                  .DKIDLYDERGKLIESGVPLDAISPLYNPAIQRTASLAKRTIAVNLAGIEKSLKSG......R......VGG--GYIKGKEIDAPVVANAEKVAAKVKE.YV.KVdSSDDDTDVRVFSEGKNMIVIVPSRRMDAGVEYTTGFTTTAAAVTQAIIDEFDVD....M....FHANMVKGAVWGRYPQTLNFV.GSNLTSILDVPQVNEG......
A0A0E3NTF4_9EURY/3-184              .DTVDIYDDRGKLLESNVDIMSLAPTRNAAIQKIIMDTKRSVAVNLGGIQNALATG......K......MGGKGRQILGRELDYDIVGRADEIAEKVKA.LV.QV.DEGDDTNVTVLNGGKNLRIQSPTSRILSGADYMSSTTVGAAAVTQTLIDMFGTD....M....YDAMIVKSAIWGSYPQTMDLM.GGSVAGILNIPQNNEG......
F7XL10_METZD/3-184                  e-KIDIYDDRGKLLESGVDLVEIAPTRNKAIQKIVTETKRSVAINLAGIEKALSTG......K......MGGKGRQILGNELDYDIVGNAGAIQDEVQK.LV.QV.SEGDDTNIATLGGGKQLLVQVPTVRTTAGADYVSAVTVGAAAVVQSIMNQFNTD....I....FDAPYVKAAVWGSYPQTMDLA.GGNVASILSIPQKNEG......
D3E054_METRM/6-187                  .DKVDLYDDRGSLVESDVPIEALSPLRNPAIKNIISGVKRTVAVNLEGIEKSLKTA......S......VGGAKSKILGREMDLDIVAQADSINASLKE.ML.QV.TEDDDTKCEILSGGKRILVQIPTIRLDSSAEYSVATLATATALTQAIIKEFDVS....M....YDANMVKAAILGRYPQSVEYM.GSNLKTMLDVPQKLEG......
A0A0P8AI73_9EURY/3-184              .DTIDLYSDRGAKLKSGVDINDISPMRNAAIKSIVTGIKRTAAVDLAGIEKTLATS......A......IGGKGRKIPGREMKLDIVKNAAAIQKAVTE.MV.QV.DSGDDTVVKALNGGKQLIVQVPSVRIDVAAEYVSSLTCTASAVTQALVSQFNIG....M....FDAPTVKSAVWGQYPQTLDMV.GGNVKSIVEIPQKDEG......
#=GC SS_cons                        .-EEEEE-TTS-EEEEEEEGGGGSTTT-HHHHHHHHHHHHEEEEEHHHHHHHHHH-......-......-SSTT---TT------TGGGHHHHHHHHHH.HH.-S.STTSS-EEEEECCCTEEEEE--HHHHHTSSSSTHHHHHHHHHHHHHHHHHTT--....G....GGHHHHHHHHHTTTTTSSS-T.T-SEE-SS--GGG-SS......
#=GC seq_cons                       .DpIDLYDDcGKLLcSsVsL-ulSPLhNsAIpcIlshsKRTVAVNLuGIEpuL+oG......p......lGGttspIhGRELDLsIVsNA-AIup+lKc.hl.QV.sEsDDTslchlsGGKpLLVQVPotRlcsAA-YssuhossAuAsspAIIDpFcls....h....FDAshVKAAVaGpYPQThDht.GuNlsolLsIPQppEG......
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