GenomeNet

Database: Pfam
Entry: MHCassoc_trimer
LinkDB: MHCassoc_trimer
Original site: MHCassoc_trimer 
#=GF ID   MHCassoc_trimer
#=GF AC   PF08831.6
#=GF DE   Class II MHC-associated invariant chain trimerisation domain
#=GF AU   Mistry J
#=GF SE   pdb_1iie
#=GF GA   25.00 25.00;
#=GF TC   40.40 53.60;
#=GF NC   22.40 18.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9843486
#=GF RT   Structure of a trimeric domain of the MHC class II-associated
#=GF RT   chaperonin and targeting protein Ii. 
#=GF RA   Jasanoff A, Wagner G, Wiley DC; 
#=GF RL   EMBO J. 1998;17:6812-6818.
#=GF DR   INTERPRO; IPR011988;
#=GF DR   SCOP; 1iie; sf;
#=GF CC   The class II associated invariant chain peptide is required for
#=GF CC   folding and localisation of MHC class II heterodimers.  This
#=GF CC   domain is involved in trimerisation of the ectoderm and
#=GF CC   interferes with DM/class II binding.  The trimeric protein forms
#=GF CC   a cylindrical shape which is thought to be important for
#=GF CC   interactions between the invariant chain and class II molecules
#=GF CC   [1].
#=GF SQ   114
#=GS G3R7S6_GORGO/136-204  AC G3R7S6.1
#=GS Q9BD54_CHICK/126-194  AC Q9BD54.2
#=GS K7E537_MONDO/116-184  AC K7E537.1
#=GS Q06KB6_DICLA/125-188  AC Q06KB6.1
#=GS F6V5T6_CALJA/140-208  AC F6V5T6.1
#=GS F7E9S4_MACMU/134-202  AC F7E9S4.1
#=GS H0YRJ5_TAEGU/122-190  AC H0YRJ5.1
#=GS L9KN01_TUPCH/120-188  AC L9KN01.1
#=GS W5PBE0_SHEEP/134-202  AC W5PBE0.1
#=GS K7G5D8_PELSI/129-197  AC K7G5D8.1
#=GS W5MYQ4_LEPOC/126-189  AC W5MYQ4.1
#=GS Q764N1_PIG/118-186    AC Q764N1.1
#=GS G1KQJ0_ANOCA/112-180  AC G1KQJ0.2
#=GS C1BLW9_OSMMO/124-187  AC C1BLW9.1
#=GS F7AJH7_ORNAN/117-185  AC F7AJH7.1
#=GS V8NV32_OPHHA/110-178  AC V8NV32.1
#=GS L8I7V9_9CETA/118-186  AC L8I7V9.1
#=GS Q3U4Q8_MOUSE/119-187  AC Q3U4Q8.1
#=GS G1QEN4_MYOLU/120-188  AC G1QEN4.1
#=GS C3UWD6_LUTAR/124-188  AC C3UWD6.1
#=GS H2R586_PANTR/136-204  AC H2R586.1
#=GS I0FWR3_MACMU/134-202  AC I0FWR3.1
#=GS B9EQ96_SALSA/127-191  AC B9EQ96.1
#=GS R0LQF9_ANAPL/102-170  AC R0LQF9.1
#=GS G3TJE1_LOXAF/120-188  AC G3TJE1.1
#=GS H2LJJ2_ORYLA/123-187  AC H2LJJ2.1
#=GS Q24KA3_ANAPL/119-187  AC Q24KA3.1
#=GS M3YQS4_MUSPF/120-188  AC M3YQS4.1
#=GS Q6PB08_XENLA/126-193  AC Q6PB08.1
#=GS D2H8L9_AILME/97-165   AC D2H8L9.1
#=GS K4G043_CALMI/128-195  AC K4G043.1
#=GS M4A2I1_XIPMA/126-189  AC M4A2I1.1
#=GS M3VXS2_FELCA/120-188  AC M3VXS2.1
#=GS U6FVB0_HUMAN/136-204  AC U6FVB0.1
#=GS E0ADT5_9AVES/123-191  AC E0ADT5.1
#=GS Q5RFJ4_PONAB/136-204  AC Q5RFJ4.1
#=GS F6ZRD0_XENTR/125-192  AC F6ZRD0.1
#=GS G1SKK3_RABIT/135-203  AC G1SKK3.2
#=GS Q2KM23_ANAPL/20-88    AC Q2KM23.1
#=GS Q29630_BOVIN/118-186  AC Q29630.1
#=GS HG2A_MOUSE/119-187    AC P04441.3
#=GS Q1M0P6_COLLI/116-184  AC Q1M0P6.1
#=GS D9IVE6_9AVES/123-191  AC D9IVE6.1
#=GS I0FWR4_MACMU/134-202  AC I0FWR4.1
#=GS B5G120_TAEGU/120-188  AC B5G120.1
#=GS F1NYL5_CHICK/124-192  AC F1NYL5.1
#=GS G3HS40_CRIGR/166-233  AC G3HS40.1
#=GS B5X6G6_SALSA/123-187  AC B5X6G6.1
#=GS Q6R7Z7_CHICK/124-192  AC Q6R7Z7.1
#=GS Q4RZ98_TETNG/123-187  AC Q4RZ98.1
#=GS HG2A_HUMAN/136-204    AC P04233.3
#=GS HG2A_HUMAN/136-204    DR PDB; 1IIE C; 120-188;
#=GS HG2A_HUMAN/136-204    DR PDB; 1IIE B; 120-188;
#=GS HG2A_HUMAN/136-204    DR PDB; 1IIE A; 120-188;
#=GS Q307W8_CAICR/126-194  AC Q307W8.1
#=GS Q6J613_CHICK/124-192  AC Q6J613.1
#=GS HG2A_RAT/120-187      AC P10247.2
#=GS K4GAA9_CALMI/128-195  AC K4GAA9.1
#=GS Q2KM24_ANAPL/123-190  AC Q2KM24.1
#=GS A5A6L4_PANTR/136-204  AC A5A6L4.1
#=GS K9IYW2_DESRO/121-188  AC K9IYW2.1
#=GS I3K5M3_ORENI/126-189  AC I3K5M3.1
#=GS G3Q1Q6_GASAC/122-186  AC G3Q1Q6.1
#=GS Q8JFN4_ONCMY/128-191  AC Q8JFN4.1
#=GS C1BW15_ESOLU/128-192  AC C1BW15.1
#=GS F2VQT3_EPICO/127-178  AC F2VQT3.1
#=GS G7P8P8_MACFA/134-202  AC G7P8P8.1
#=GS U3K012_FICAL/120-188  AC U3K012.1
#=GS G7MVM5_MACMU/134-202  AC G7MVM5.1
#=GS G3X0Q6_SARHA/117-186  AC G3X0Q6.1
#=GS G3Q1R2_GASAC/131-197  AC G3Q1R2.1
#=GS G3U7Y6_LOXAF/120-188  AC G3U7Y6.1
#=GS H2SNE4_TAKRU/125-188  AC H2SNE4.1
#=GS H2BJQ3_GINCI/120-187  AC H2BJQ3.1
#=GS V5QRM8_CAIMO/123-191  AC V5QRM8.1
#=GS H2QRT2_PANTR/136-204  AC H2QRT2.1
#=GS H0YBZ2_HUMAN/131-199  AC H0YBZ2.1
#=GS D6QUQ3_COTJA/124-192  AC D6QUQ3.1
#=GS Q6J614_CHICK/124-192  AC Q6J614.1
#=GS M1VPF6_HUMAN/136-204  AC M1VPF6.1
#=GS G1RHB8_NOMLE/136-204  AC G1RHB8.1
#=GS S9XLT6_9CETA/118-186  AC S9XLT6.1
#=GS F6TGS3_HORSE/120-188  AC F6TGS3.1
#=GS F7ENE8_CALJA/140-208  AC F7ENE8.1
#=GS H3B8G7_LATCH/132-199  AC H3B8G7.1
#=GS B4DUJ2_HUMAN/48-116   AC B4DUJ2.1
#=GS Q8JFN5_ONCMY/125-189  AC Q8JFN5.1
#=GS M7AY47_CHEMY/285-353  AC M7AY47.1
#=GS Q7JFY1_BOVIN/111-179  AC Q7JFY1.1
#=GS F7ENE3_CALJA/136-204  AC F7ENE3.1
#=GS G5C391_HETGA/121-189  AC G5C391.1
#=GS E2RF90_CANFA/136-204  AC E2RF90.2
#=GS H3D9Q2_TETNG/125-189  AC H3D9Q2.1
#=GS S7N2W2_MYOBR/105-173  AC S7N2W2.1
#=GS L5LQM9_MYODS/120-188  AC L5LQM9.1
#=GS A9YLN4_HUMAN/136-204  AC A9YLN4.1
#=GS H0WQB3_OTOGA/120-188  AC H0WQB3.1
#=GS G1N4A4_MELGA/101-168  AC G1N4A4.2
#=GS E1B279_COTJA/124-192  AC E1B279.1
#=GS F6VER1_CALJA/48-116   AC F6VER1.1
#=GS G3USV8_MELGA/101-168  AC G3USV8.1
#=GS G9C7P1_CAIMO/123-191  AC G9C7P1.1
#=GS L5L1G3_PTEAL/120-188  AC L5L1G3.1
#=GS F7ENM4_CALJA/135-203  AC F7ENM4.1
#=GS F7E6Z5_XENTR/99-167   AC F7E6Z5.1
#=GS Q6EE25_SINCH/125-188  AC Q6EE25.1
#=GS Q9MXD5_HORSE/120-188  AC Q9MXD5.1
#=GS H2BJQ2_GINCI/131-198  AC H2BJQ2.1
#=GS H0UZ94_CAVPO/120-188  AC H0UZ94.1
#=GS U3J8L0_ANAPL/102-170  AC U3J8L0.1
#=GS Q6GT70_RAT/120-187    AC Q6GT70.1
#=GS W5MYP5_LEPOC/126-189  AC W5MYP5.1
#=GS B5XH65_SALSA/122-186  AC B5XH65.1
#=GS I3MCR9_SPETR/119-187  AC I3MCR9.1
#=GS Q545Y5_MOUSE/119-187  AC Q545Y5.1
#=GS G1LDD9_AILME/136-204  AC G1LDD9.1
#=GS B6VAR1_EPIAK/127-192  AC B6VAR1.1
G3R7S6_GORGO/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
Q9BD54_CHICK/126-194             .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
K7E537_MONDO/116-184             .....NSTTDQVKYLLQRSDPRRSFPDLTKSFQENLKHLKSNMDPKNWKTFENWMHQWLLFEMSKKPKEEKTE-t......
Q06KB6_DICLA/125-188             ....v-SVEKQVKDLIQDSQ----LPQFNETFMANLQSLKQHINESEWQSFESWMRYWLIFQMAQKTP------vppta..
F6V5T6_CALJA/140-208             .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
F7E9S4_MACMU/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
H0YRJ5_TAEGU/122-190             .....NKTEDLVKHVLLQADPSKMFPELKDNLMDNLKRLRSTMTHVDWKSFESWMHKWLLFEMAKNPQSEDRK-a......
L9KN01_TUPCH/120-188             .....NMTQDHVMHLLLKADPLKVYPQLKGSFPENLKHLKSTMETMDWKVFESWMHQWLLFEMSKNSMEEKPTE.......
W5PBE0_SHEEP/134-202             .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFENWLHQWLLFEMSKNSLEEKPF-e......
K7G5D8_PELSI/129-197             .....NKTEDQVKHLLLRADPSKMFPELKDSLMENLNRLKNTMTDQDWQSFESWMHKWLLFEMAKKPQTQEPA-e......
W5MYQ4_LEPOC/126-189             ...vs--LEKQVKDLLQDEN----LPQFNETFLGNLQGMKSQMEDSEWKSFESWMRSWLIFQMAQQQPPK----ptp....
Q764N1_PIG/118-186               .....NMTQDHVMHLLLKSDPLGVYPKLKGSLPENLKHLKNTMDGVNWKLFENWLRQWLLFEMSKNSLEETP--fe.....
G1KQJ0_ANOCA/112-180             .....NSTEDQVKRVLLRENPLRKFPEFNSSFIENIGQMRFRMDYEDWKAFETWMHKWLLFQMAQNAIPEEK--vk.....
C1BLW9_OSMMO/124-187             ....v-SVEKQVKDLLQNVS----LPEFNQSFLKNVQSLQTKMESEEWMSFETWMRHWLIFQMAQQSPP-----vpas...
F7AJH7_ORNAN/117-185             .....NSTTDQVMHLLLKGAPTKIYPELNEGFQDNMEQLKNNMGHESWQNFKHWMHHWLLFELSKKPQNAAPT-e......
V8NV32_OPHHA/110-178             .....NSTEDQVKRLLLRENPTRTFPELKSTFQENMGHLKIRMPYNDWKEFETWMHKWLIFQMAQKQNTEEK--gk.....
L8I7V9_9CETA/118-186             .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEEKPF-e......
Q3U4Q8_MOUSE/119-187             .....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKK--pte....
G1QEN4_MYOLU/120-188             .....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGEKL--te.....
C3UWD6_LUTAR/124-188             ....v-SVEKQVKDLVQDSQ----LPQFNETFLANMRSLKHQLNETEWQSFETWMRYWLIFQMAQQQPP-----pptaq..
H2R586_PANTR/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
I0FWR3_MACMU/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
B9EQ96_SALSA/127-191             ...vs--LEDQVKDLLQNPQ----LPQFNETFLANLQSLKQQVEETEWEGFETWVRYWLLFQMAQEKPPAPP--tp.....
R0LQF9_ANAPL/102-170             .....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
G3TJE1_LOXAF/120-188             .....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEEKPTE.......
H2LJJ2_ORYLA/123-187             ....v-SVEKQLMDLMQDFS----LPKFNETFQANLETLRQQVNESEWQTFETWMRYWLIFQMAQKQPPA----ptpq...
Q24KA3_ANAPL/119-187             .....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
M3YQS4_MUSPF/120-188             .....NMTQDHVMHVLLETDPLKVYPKLKGSFLENLKHLKNTMGPLEWKVFESWMYQWLLFEMSKNSLENKPE-v......
Q6PB08_XENLA/126-193             .....NKVEDAAKYMLLRGNPLRKYPSLNGSILENLRELKKALTDKEWMSFDTWMQQWYLFFLVQNTEK-----paep...
D2H8L9_AILME/97-165              .....NMTQDHVMHMLLEADPLKVYPKLKGSFPENLKHLKRTMETLDWKVFENWMYQWLLFEMSKNSLEDKPE-v......
K4G043_CALMI/128-195             ..tlm----QEVEELLKKENLTQELPKFKGTLFSNLRTLRENVEEPMWREFETWLRNWLMFQLIQEQQQK----isst...
M4A2I1_XIPMA/126-189             ....v-SVEKQVMDMMKDIS----LPQFNETFLANLRSLKQQFNDSEWKSFESWMRYWLIFQMAQQEP------agptp..
M3VXS2_FELCA/120-188             .....NMTQDHVMHMLLEGDPLKVYPQLKGNFPENLKHLKNTMGTLDWKVFENWMYQWLLFEMSKNSLEKHPA-d......
U6FVB0_HUMAN/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
E0ADT5_9AVES/123-191             .....NKTEDQVRHLLLQGDPRKMFPELKDSLLDNLKSLKKTMTDVDWKSFESWMHKWLLFEMAKSPKPDERK-a......
Q5RFJ4_PONAB/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
F6ZRD0_XENTR/125-192             .....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNTGKA----aep....
G1SKK3_RABIT/135-203             .....NTTQDYVMHLLLRSDPLKVYPQLKGSFPENLKQLKGTMDGLNWKVFESWLHQWLLFEMSKNSLEEKPTE.......
Q2KM23_ANAPL/20-88               .....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
Q29630_BOVIN/118-186             .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEEKPF-e......
HG2A_MOUSE/119-187               .....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKK--pte....
Q1M0P6_COLLI/116-184             .....NRTEDQVKHLLLQGDPRKMFPDLKANLMDNMKTLKNTMTDMDWKAFESWMHKWLLFEMAKNPKPEDPK-m......
D9IVE6_9AVES/123-191             .....NKTEDQVRHLLLQGDPRKMFPELKDSLLDNLKSLKKTMTDVDWKSFESWMHKWLLFEMAKSPKPDERK-a......
I0FWR4_MACMU/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
B5G120_TAEGU/120-188             .....NKTEDLVKHVLLQADPSKMFPELKDNLMDNLKRLRSTMTHVDWKSFESWMHKWLLFEMAKNPQSEDRK-a......
F1NYL5_CHICK/124-192             .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
G3HS40_CRIGR/166-233             .....NMTQDHVMHLLLRSGPLD-YPKLKGSFPENLKHLKNSMDGLNWKVFESWMKQWLLFEMSKNSLEEKPTE.......
B5X6G6_SALSA/123-187             ...vs--LEKQVKDLLQNPQ----LPQFNETFLANLQSLKRQMEEAEWKGFEAWTRNWLLFQMAQEKPPA----ttpq...
Q6R7Z7_CHICK/124-192             .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
Q4RZ98_TETNG/123-187             ....v-SVETQVKDLLQNFT----LPAFNSTFASNLLALKSQMDQTTWQKLESWMQSWLIFQMAQEKPP-----titat..
HG2A_HUMAN/136-204               .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
#=GR HG2A_HUMAN/136-204    SS    .....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS------......
Q307W8_CAICR/126-194             .....NKTEDQVKHLLLMGDPSKMFPELRNSMMENLKNLKNSMSYSDWQSFESWMHKWLLFEMAKNPQTEEPT-k......
Q6J613_CHICK/124-192             .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
HG2A_RAT/120-187                 .....NMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQ--pt.....
K4GAA9_CALMI/128-195             ..tlm----QEVEELLKKENLTQELPKFKGTLFSNLRTLRENVEEPMWREFETWLRNWLMFQLIQEQQQK----isst...
Q2KM24_ANAPL/123-190             .....NKTEDQVRHLLL-ADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
A5A6L4_PANTR/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
K9IYW2_DESRO/121-188             .....NTTLDHVMHLLLKADPLKVYPQLKGTFPENLKKLKRTMEGLDWKVFESWMHQWLLFEMSKNSPEK----lte....
I3K5M3_ORENI/126-189             ....v-SVEKQLMDLMQDSE----LPQFNETFLANLQTLKQHMNDSEWKSFETWMRYWLIFKMAQQQPA-----tptp...
G3Q1Q6_GASAC/122-186             ...vs--LETQVKNLMQGSQ----LPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPP-----tptpq..
Q8JFN4_ONCMY/128-191             ....s--LEEQVKNLLQNPQ----LPQFNETFLANLQSLKKQVEETEWEGFETWARYWLLFQMAQEKPP-----vlptp..
C1BW15_ESOLU/128-192             ...qs--LEKQVKDLLQNPE----LPQFNETFLANLQGLKKQMESNEWKDFETWTRNWLIFQMAQEKT------avsatp.
F2VQT3_EPICO/127-178             ...vn--VEAQLKELLQEDS---QLPEFNETFLANLQGMKQHVSETDWKSFESWMRYWLI--------------.......
G7P8P8_MACFA/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
U3K012_FICAL/120-188             .....NKTEDQVKHLLLQADPSKMFPELRDNLMDNLKRLRSTMTHADWKSFESWMHKWLLFEMAKNPKSEDRK-a......
G7MVM5_MACMU/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
G3X0Q6_SARHA/117-186             .....NNTKDQVKYLLLQSDPRRSFPELTKSFQENMKKLKNNMETKNWKNFENWMHQWLLFEMSKKPNEENV--ekk....
G3Q1R2_GASAC/131-197             ...gl---ETQVKNLMQ-VGPRVLLPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPP-----tptpq..
G3U7Y6_LOXAF/120-188             .....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEEKPTE.......
H2SNE4_TAKRU/125-188             ....v-SVETQVKDLLQDFK----LPLFNSTFIPNLLALKQQMNETVWEEFESWMQFWLIFQMAQEKA------pllta..
H2BJQ3_GINCI/120-187             ...tv---LEQVEELLKKDNATKEIPEFNSTFSANLDLLRDSMTESEWQDFETWLRNWLFFQLIQEKKSA----ptts...
V5QRM8_CAIMO/123-191             .....NKTEDQVRHLLLQADPKKMFPELKDSLLDNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
H2QRT2_PANTR/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
H0YBZ2_HUMAN/131-199             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
D6QUQ3_COTJA/124-192             .....NKTEDQVRHLLLKADPRKTFPELKEDLLGNLKRLKKAMNAMDWQDFEAWMHKWLLFEMAKGPKGEEQN-a......
Q6J614_CHICK/124-192             .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
M1VPF6_HUMAN/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
G1RHB8_NOMLE/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
S9XLT6_9CETA/118-186             .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKNTMDGMNWKLFENWMHYWLLFEMSKNSQEEQP--fe.....
F6TGS3_HORSE/120-188             .....NTTQDHVMHLLLRADPLKVYPQLKGSFQENLKHLKSTMDGLDWKVFENWMHQWLLFEMSRNSLEEKPT-q......
F7ENE8_CALJA/140-208             .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
H3B8G7_LATCH/132-199             vdimg-----QVLEML-QQNPQLAFPNMTGNFLENLNGLKEQMQKPNWQEFESWLQHWFLFQLVQKQSQP----qsva...
B4DUJ2_HUMAN/48-116              .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
Q8JFN5_ONCMY/125-189             ...vs--LEKQVKDLLQSPQ----LPQFNETFLANLQSLKRQMEEAEWKGFETWARNWLLFQMAQEKPPA----pttp...
M7AY47_CHEMY/285-353             .....NSTTDQVKHLLLRADPSKMFPELKNNLMENLNHLKHTMTNQDWQSFESWMHKWLLFEMAKTPQTVQPT-e......
Q7JFY1_BOVIN/111-179             .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEEKPF-e......
F7ENE3_CALJA/136-204             .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
G5C391_HETGA/121-189             .....NMTQDHVMHMLLKSDPLKVYPQLEGSFLDNLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPGEKPT-e......
E2RF90_CANFA/136-204             .....NMTQDHVMHLLLEADPLKVYPKLKGSFPENLKHLKNTMETLDWKVFENWMYQWLLFEMSKNSLEKKST-e......
H3D9Q2_TETNG/125-189             ....v-SVETQVKDLLQNFT----LPAFNSTFASNLLALKSQMDQTTWQKLESWMQSWLIFQMAQEKPP-----titat..
S7N2W2_MYOBR/105-173             .....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGEKL--te.....
L5LQM9_MYODS/120-188             .....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGEKL--te.....
A9YLN4_HUMAN/136-204             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
H0WQB3_OTOGA/120-188             .....NMTQDHVMHLLLKADPLKVYPQMKGNFPENLKHLKSTMETLDWKVFESWMHQWLLFEMSKNSGEEKPTE.......
G1N4A4_MELGA/101-168             .....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEEQ---na.....
E1B279_COTJA/124-192             .....NKTEDQVRHLLLKADPRKTFPELKEDLLGNLKRLKKAMNAMDWQDFEAWMHKWLLFEMAKGPKGEEQN-a......
F6VER1_CALJA/48-116              .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
G3USV8_MELGA/101-168             .....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEEQ---na.....
G9C7P1_CAIMO/123-191             .....NKTEDQVRHLLLQADPKKMFPELKDSLLDNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
L5L1G3_PTEAL/120-188             .....NSTLDHVMHLLLKSDPLKVYPQLKGSFPENLKRLRNTMEGLDWKAFENWMHQWLLFEMSKNSLEEKPK-p......
F7ENM4_CALJA/135-203             .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
F7E6Z5_XENTR/99-167              .....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNT-------gifieaq
Q6EE25_SINCH/125-188             ....v-SVEKQLKDLMQDSQ----LPQFNETFLANLQGLKQQMNESEWKSFESWMRYWLIFQMAQQK-------pvppta.
Q9MXD5_HORSE/120-188             .....NTTQDHVMHLLLRADPLKVYPQLKGSFQENLKHLKSTMDGLDWKVFENWMHQWLLFEMSRNSLEEKPT-q......
H2BJQ2_GINCI/131-198             ...tv---LEQVEELLKKDNATKEIPEFNSTFSANLDLLRDSMTESEWQDFETWLRNWLFFQLIQEKKSA----ptts...
H0UZ94_CAVPO/120-188             .....NTTQDYVMHTLLKSDPLKVYPQLQGSFLENLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPEEKPTE.......
U3J8L0_ANAPL/102-170             .....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
Q6GT70_RAT/120-187               .....NMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQ--pt.....
W5MYP5_LEPOC/126-189             ...vs--LEKQVKDLLQDEN----LPQFNETFLGNLQGMKSQMEDSEWKSFESWMRSWLIFQMAQQQPPK----ptp....
B5XH65_SALSA/122-186             ...vs--LEKQVKDLLQNPQ----LPQFNETFLANLQSLKRQMEEAEWKGFEAWTRNWLLFQMAQEKPPA----ttpq...
I3MCR9_SPETR/119-187             .....NMTQDHVMHLLLKSNPLKVYPQLKGSFPENLKHLKSTMDNLDWKIFENWLHQWLLFEMSKNSLEEKPTE.......
Q545Y5_MOUSE/119-187             .....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKK--pte....
G1LDD9_AILME/136-204             .....NMTQDHVMHMLLEADPLKVYPKLKGSFPENLKHLKRTMETLDWKVFENWMYQWLLFEMSKNSLEDKPE-v......
B6VAR1_EPIAK/127-192             ....v-SVEAQLKELLQEDS---QLPQFNETFLANLQGMKQHVNETDWKSFESWMRYWLIFQIAQRTP------apptae.
#=GC SS_cons                     .....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS------......
#=GC seq_cons                    .....NhTEDpVhHLLhpuDPhKhaPpLKsoF.-NL++LKpoMpshDWKsFESWMHpWLLFEMu+pshppc...s......
//
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