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Database: Pfam
Entry: MHCassoc_trimer
LinkDB: MHCassoc_trimer
Original site: MHCassoc_trimer 
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#=GF ID   MHCassoc_trimer
#=GF AC   PF08831.5
#=GF DE   Class II MHC-associated invariant chain trimerisation domain
#=GF AU   Mistry J
#=GF SE   pdb_1iie
#=GF GA   25.00 25.00;
#=GF TC   55.00 55.00;
#=GF NC   21.50 18.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9843486
#=GF RT   Structure of a trimeric domain of the MHC class II-associated
#=GF RT   chaperonin and targeting protein Ii. 
#=GF RA   Jasanoff A, Wagner G, Wiley DC; 
#=GF RL   EMBO J. 1998;17:6812-6818.
#=GF DR   INTERPRO; IPR011988;
#=GF DR   SCOP; 1iie; sf;
#=GF CC   The class II associated invariant chain peptide is required for
#=GF CC   folding and localisation of MHC class II heterodimers.  This
#=GF CC   domain is involved in trimerisation of the ectoderm and
#=GF CC   interferes with DM/class II binding.	The trimeric protein forms
#=GF CC   a cylindrical shape which is thought to be important for
#=GF CC   interactions between the invariant chain and class II molecules
#=GF CC   [1].
#=GF SQ   94
#=GS E1BZH6_CHICK/124-195  AC E1BZH6.1
#=GS Q764N1_PIG/118-189    AC Q764N1.1
#=GS Q06KB6_DICLA/125-191  AC Q06KB6.1
#=GS C1BW15_ESOLU/128-195  AC C1BW15.1
#=GS F6TGS3_HORSE/120-191  AC F6TGS3.1
#=GS D2H8L9_AILME/97-167   AC D2H8L9.1
#=GS C3UWD6_9PERO/124-190  AC C3UWD6.1
#=GS Q6J613_CHICK/124-195  AC Q6J613.1
#=GS Q307W8_CAICR/126-197  AC Q307W8.1
#=GS G3TJE1_LOXAF/120-191  AC G3TJE1.1
#=GS F6ZRD0_XENTR/125-196  AC F6ZRD0.1
#=GS Q6PB08_XENLA/126-197  AC Q6PB08.1
#=GS H2SNE4_TAKRU/125-193  AC H2SNE4.1
#=GS C1BLW9_OSMMO/124-190  AC C1BLW9.1
#=GS H2BJQ2_GINCI/131-200  AC H2BJQ2.1
#=GS G1N4A4_MELGA/101-171  AC G1N4A4.2
#=GS HG2A_MOUSE/119-190    AC P04441.3
#=GS Q1M0P6_COLLI/116-187  AC Q1M0P6.1
#=GS F7F9X3_MONDO/116-187  AC F7F9X3.1
#=GS F7ENE8_CALJA/140-211  AC F7ENE8.1
#=GS G7MVM5_MACMU/134-205  AC G7MVM5.1
#=GS H2BJQ3_GINCI/120-189  AC H2BJQ3.1
#=GS Q7JFY1_BOVIN/111-182  AC Q7JFY1.1
#=GS H0YRJ5_TAEGU/122-193  AC H0YRJ5.1
#=GS A9YLN4_HUMAN/136-207  AC A9YLN4.1
#=GS H2R586_PANTR/136-207  AC H2R586.1
#=GS F6VER1_CALJA/48-119   AC F6VER1.1
#=GS Q6J614_CHICK/124-195  AC Q6J614.1
#=GS G3U7Y6_LOXAF/120-191  AC G3U7Y6.1
#=GS I0FWR3_MACMU/134-205  AC I0FWR3.1
#=GS G3Q1Q6_GASAC/122-189  AC G3Q1Q6.1
#=GS Q2KM24_ANAPL/123-193  AC Q2KM24.1
#=GS E0ADT5_9AVES/123-194  AC E0ADT5.1
#=GS B5G120_TAEGU/120-191  AC B5G120.1
#=GS G3Q1R2_GASAC/131-200  AC G3Q1R2.1
#=GS G5C391_HETGA/121-192  AC G5C391.1
#=GS H2LJJ2_ORYLA/123-189  AC H2LJJ2.1
#=GS G1RHB8_NOMLE/136-207  AC G1RHB8.1
#=GS D9IVE6_9AVES/123-194  AC D9IVE6.1
#=GS G1SKK3_RABIT/135-206  AC G1SKK3.1
#=GS H3B8G7_LATCH/133-202  AC H3B8G7.1
#=GS B5XH65_SALSA/123-189  AC B5XH65.1
#=GS Q9BD54_CHICK/126-197  AC Q9BD54.2
#=GS B9EQ96_SALSA/128-194  AC B9EQ96.1
#=GS E1B279_COTJA/124-195  AC E1B279.1
#=GS HG2A_RAT/120-191      AC P10247.2
#=GS G7P8P8_MACFA/134-205  AC G7P8P8.1
#=GS D6QUQ3_COTJA/124-195  AC D6QUQ3.1
#=GS F6V5T6_CALJA/140-211  AC F6V5T6.1
#=GS F2VQT3_EPICO/127-178  AC F2VQT3.1
#=GS G3USV8_MELGA/101-171  AC G3USV8.1
#=GS H0UZ94_CAVPO/120-191  AC H0UZ94.1
#=GS H2PH33_PONAB/136-207  AC H2PH33.1
#=GS F7ENE3_CALJA/136-207  AC F7ENE3.1
#=GS F1NYL5_CHICK/124-195  AC F1NYL5.1
#=GS Q24KA3_ANAPL/119-190  AC Q24KA3.1
#=GS Q6R7Z7_CHICK/124-195  AC Q6R7Z7.1
#=GS Q4RZ98_TETNG/123-190  AC Q4RZ98.1
#=GS F7AJH0_ORNAN/117-188  AC F7AJH0.1
#=GS Q545Y5_MOUSE/119-190  AC Q545Y5.1
#=GS Q29630_BOVIN/118-189  AC Q29630.1
#=GS F1PEC9_CANFA/136-207  AC F1PEC9.1
#=GS Q8JFN5_ONCMY/125-192  AC Q8JFN5.1
#=GS F7ENM4_CALJA/135-206  AC F7ENM4.1
#=GS B5X6G6_SALSA/124-190  AC B5X6G6.1
#=GS H0WQB3_OTOGA/120-191  AC H0WQB3.1
#=GS Q5RFJ4_PONAB/136-207  AC Q5RFJ4.1
#=GS E2RF90_CANFA/120-191  AC E2RF90.1
#=GS G1QEN4_MYOLU/120-191  AC G1QEN4.1
#=GS F7AJH7_ORNAN/117-188  AC F7AJH7.1
#=GS G3R7S6_GORGO/136-207  AC G3R7S6.1
#=GS F6TWK9_MONDO/132-193  AC F6TWK9.1
#=GS H3D9Q2_TETNG/125-192  AC H3D9Q2.1
#=GS Q6EE25_SINCH/125-191  AC Q6EE25.1
#=GS B4DUJ2_HUMAN/48-119   AC B4DUJ2.1
#=GS Q9MXD5_HORSE/120-191  AC Q9MXD5.1
#=GS A5A6L4_PANTR/136-207  AC A5A6L4.1
#=GS G1KQJ0_ANOCA/133-204  AC G1KQJ0.1
#=GS Q3U4Q8_MOUSE/119-190  AC Q3U4Q8.1
#=GS G3HS40_CRIGR/166-236  AC G3HS40.1
#=GS G3X0Q6_SARHA/117-189  AC G3X0Q6.1
#=GS Q2KM23_ANAPL/20-91    AC Q2KM23.1
#=GS G9C7P1_CAIMO/123-194  AC G9C7P1.1
#=GS G1RHC0_NOMLE/136-207  AC G1RHC0.1
#=GS HG2A_HUMAN/136-207    AC P04233.3
#=GS HG2A_HUMAN/136-207    DR PDB; 1IIE C; 120-191;
#=GS HG2A_HUMAN/136-207    DR PDB; 1IIE B; 120-191;
#=GS HG2A_HUMAN/136-207    DR PDB; 1IIE A; 120-191;
#=GS F7E9S4_MACMU/134-205  AC F7E9S4.1
#=GS Q6GT70_RAT/120-191    AC Q6GT70.1
#=GS H0YBZ2_HUMAN/131-202  AC H0YBZ2.1
#=GS Q8JFN4_ONCMY/128-194  AC Q8JFN4.1
#=GS G1LDD9_AILME/136-206  AC G1LDD9.1
#=GS F7E6Z5_XENTR/99-170   AC F7E6Z5.1
#=GS B6VAR1_EPIAK/127-197  AC B6VAR1.1
#=GS I0FWR4_MACMU/134-205  AC I0FWR4.1
#=GS H2QRT2_PANTR/136-207  AC H2QRT2.1
E1BZH6_CHICK/124-195             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
Q764N1_PIG/118-189               ....NMTQDHVMHLLLKSDPLGVYPKLKGSLPENLKHLKNTMDGVNWKLFENWLRQWLLFEMSKNSLEE.TPFEVPP..........
Q06KB6_DICLA/125-191             ..vs--VEKQVKDLIQDSQ----LPQFNETFMANLQSLKQHINESEWQSFESWMRYWLIFQMAQKTPVP.-PTADPA..........
C1BW15_ESOLU/128-195             ..qs--LEKQVKDLLQNPE----LPQFNETFLANLQGLKKQMESNEWKDFETWTRNWLIFQMAQEKTAV.S------atpkps....
F6TGS3_HORSE/120-191             ....NTTQDHVMHLLLRADPLKVYPQLKGSFQENLKHLKSTMDGLDWKVFENWMHQWLLFEMSRNSLEE.KPTQGP-t.........
D2H8L9_AILME/97-167              ....NMTQDHVMHMLLEADPLKVYPKLKGSFPENLKHLKRTMETLDWKVFENWMYQWLLFEMSKNSLED.KPE----vpl.......
C3UWD6_9PERO/124-190             ..vs--VEKQVKDLVQDSQ----LPQFNETFLANMRSLKHQLNETEWQSFETWMRYWLIFQMAQQQPPP.-PTAQPA..........
Q6J613_CHICK/124-195             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
Q307W8_CAICR/126-197             ....NKTEDQVKHLLLMGDPSKMFPELRNSMMENLKNLKNSMSYSDWQSFESWMHKWLLFEMAKNPQTE.EPTKMPA..........
G3TJE1_LOXAF/120-191             ....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEE.KPTEAP-t.........
F6ZRD0_XENTR/125-196             ....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNTGKA.-------aeplppq...
Q6PB08_XENLA/126-197             ....NKVEDAAKYMLLRGNPLRKYPSLNGSILENLRELKKALTDKEWMSFDTWMQQWYLFFLVQNTEKP.-------aeplpqs...
H2SNE4_TAKRU/125-193             ..vs--VETQVKDLLQDFK----LPLFNSTFIPNLLALKQQMNETVWEEFESWMQFWLIFQMAQEKAPL.-------ltattapa..
C1BLW9_OSMMO/124-190             ..vs--VEKQVKDLLQNVS----LPEFNQSFLKNVQSLQTKMESEEWMSFETWMRHWLIFQMAQQSPPV.-------pasalq....
H2BJQ2_GINCI/131-200             .tvl----EQVEELLKKDNATKEIPEFNSTFSANLDLLRDSMTESEWQDFETWLRNWLFFQLIQEKKSA.-PTTS--ap........
G1N4A4_MELGA/101-171             ....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEE.-QNAIPA..........
HG2A_MOUSE/119-190               ....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEkKPTEAPP..........
Q1M0P6_COLLI/116-187             ....NRTEDQVKHLLLQGDPRKMFPDLKANLMDNMKTLKNTMTDMDWKAFESWMHKWLLFEMAKNPKPE.DPKMIPA..........
F7F9X3_MONDO/116-187             ....NSTTDQVKYLLQRSDPRRSFPDLTKSFQENLKHLKSNMDPKNWKTFENWMHQWLLFEMSKKPKEE.KTET---yqk.......
F7ENE8_CALJA/140-211             ....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQ.KPTEAPP..........
G7MVM5_MACMU/134-205             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQ.KPTEAPP..........
H2BJQ3_GINCI/120-189             .tvl----EQVEELLKKDNATKEIPEFNSTFSANLDLLRDSMTESEWQDFETWLRNWLFFQLIQEKKSA.-PTTS--ap........
Q7JFY1_BOVIN/111-182             ....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEE.KPFEGPP..........
H0YRJ5_TAEGU/122-193             ....NKTEDLVKHVLLQADPSKMFPELKDNLMDNLKRLRSTMTHVDWKSFESWMHKWLLFEMAKNPQSE.DRKAVPA..........
A9YLN4_HUMAN/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTDAPP..........
H2R586_PANTR/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
F6VER1_CALJA/48-119              ....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQ.KPTEAPP..........
Q6J614_CHICK/124-195             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
G3U7Y6_LOXAF/120-191             ....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEE.KPTEAP-t.........
I0FWR3_MACMU/134-205             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQ.KPTEAPP..........
G3Q1Q6_GASAC/122-189             ..vs--LETQVKNLMQGSQ----LPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPPT.-PT----pqsaa.....
Q2KM24_ANAPL/123-193             ....NKTEDQVRHLLL-ADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
E0ADT5_9AVES/123-194             ....NKTEDQVRHLLLQGDPRKMFPELKDSLLDNLKSLKKTMTDVDWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
B5G120_TAEGU/120-191             ....NKTEDLVKHVLLQADPSKMFPELKDNLMDNLKRLRSTMTHVDWKSFESWMHKWLLFEMAKNPQSE.DRKAVPA..........
G3Q1R2_GASAC/131-200             ...g--LETQVKNLMQV-GPRVLLPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPPT.-PT----pqsaa.....
G5C391_HETGA/121-192             ....NMTQDHVMHMLLKSDPLKVYPQLEGSFLDNLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPGE.KPTEAPP..........
H2LJJ2_ORYLA/123-189             ..vs--VEKQLMDLMQDFS----LPKFNETFQANLETLRQQVNESEWQTFETWMRYWLIFQMAQKQPPA.-PTPQPA..........
G1RHB8_NOMLE/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
D9IVE6_9AVES/123-194             ....NKTEDQVRHLLLQGDPRKMFPELKDSLLDNLKSLKKTMTDVDWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
G1SKK3_RABIT/135-206             ....NTTQDYVMHLLLRSDPLKVYPQLKGSFPENLKQLKGTMDGLNWKVFESWLHQWLLFEMSKNSLEE.KPTEAP-t.........
H3B8G7_LATCH/133-202             dimg-----QVLEMLQQ-NPQLAFPNMTGNFLENLNGLKEQMQKPNWQEFESWLQHWFLFQLVQKQSQP.Q------svaptt....
B5XH65_SALSA/123-189             ...s--LEKQVKDLLQNPQ----LPQFNETFLANLQSLKRQMEEAEWKGFEAWTRNWLLFQMAQEKPPA.-TT----pqpaa.....
Q9BD54_CHICK/126-197             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
B9EQ96_SALSA/128-194             ...s--LEDQVKDLLQNPQ----LPQFNETFLANLQSLKQQVEETEWEGFETWVRYWLLFQMAQEKPPA.PPTPQ--pv........
E1B279_COTJA/124-195             ....NKTEDQVRHLLLKADPRKTFPELKEDLLGNLKRLKKAMNAMDWQDFEAWMHKWLLFEMAKGPKGE.EQNAIPA..........
HG2A_RAT/120-191                 ....NMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEkQPTQTP-p.........
G7P8P8_MACFA/134-205             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQ.KPTEAPP..........
D6QUQ3_COTJA/124-195             ....NKTEDQVRHLLLKADPRKTFPELKEDLLGNLKRLKKAMNAMDWQDFEAWMHKWLLFEMAKGPKGE.EQNAIPA..........
F6V5T6_CALJA/140-211             ....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQ.KPTEAPP..........
F2VQT3_EPICO/127-178             ..vn--VEAQLKELLQEDS---QLPEFNETFLANLQGMKQHVSETDWKSFESWMRYWLI----------.-------..........
G3USV8_MELGA/101-171             ....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEE.-QNAIPA..........
H0UZ94_CAVPO/120-191             ....NTTQDYVMHTLLKSDPLKVYPQLQGSFLENLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPEE.KPTEAPP..........
H2PH33_PONAB/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
F7ENE3_CALJA/136-207             ....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQ.KPTEAPP..........
F1NYL5_CHICK/124-195             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
Q24KA3_ANAPL/119-190             ....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
Q6R7Z7_CHICK/124-195             ....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKME.EQNTIPA..........
Q4RZ98_TETNG/123-190             ..vs--VETQVKDLLQNFT----LPAFNSTFASNLLALKSQMDQTTWQKLESWMQSWLIFQMAQEKPPT.-ITATP-ap........
F7AJH0_ORNAN/117-188             ....NSTTDQVMHLLLKGAPTKIYPELNEGFQDNMEQLKNNMGHESWQNFKHWMHHWLLFELSKKPQNA.APTETP-k.........
Q545Y5_MOUSE/119-190             ....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEkKPTEAPP..........
Q29630_BOVIN/118-189             ....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEE.KPFEGPP..........
F1PEC9_CANFA/136-207             ....NMTQDHVMHLLLEADPLKVYPKLKGSFPENLKHLKNTMETLDWKVFENWMYQWLLFEMSKNSLEK.KSTEVP-l.........
Q8JFN5_ONCMY/125-192             ..vs--LEKQVKDLLQSPQ----LPQFNETFLANLQSLKRQMEEAEWKGFETWARNWLLFQMAQEKPPA.-PTTPQ-pa........
F7ENM4_CALJA/135-206             ....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQ.KPTEAPP..........
B5X6G6_SALSA/124-190             ...s--LEKQVKDLLQNPQ----LPQFNETFLANLQSLKRQMEEAEWKGFEAWTRNWLLFQMAQEKPPA.-TT----pqpaa.....
H0WQB3_OTOGA/120-191             ....NMTQDHVMHLLLKADPLKVYPQMKGNFPENLKHLKSTMETLDWKVFESWMHQWLLFEMSKNSGEE.KPTEAPP..........
Q5RFJ4_PONAB/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
E2RF90_CANFA/120-191             ....NMTQDHVMHLLLEADPLKVYPKLKGSFPENLKHLKNTMETLDWKVFENWMYQWLLFEMSKNSLEK.KSTEVP-l.........
G1QEN4_MYOLU/120-191             ....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGE.KLTE---gsp.......
F7AJH7_ORNAN/117-188             ....NSTTDQVMHLLLKGAPTKIYPELNEGFQDNMEQLKNNMGHESWQNFKHWMHHWLLFELSKKPQNA.APTETP-k.........
G3R7S6_GORGO/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
F6TWK9_MONDO/132-193             .sne----------LIRSDPRRSFPDLTKSFQENLKHLKSNMDPKNWKTFENWMHQWLLFEMSKKPKEE.KT-----et........
H3D9Q2_TETNG/125-192             ..vs--VETQVKDLLQNFT----LPAFNSTFASNLLALKSQMDQTTWQKLESWMQSWLIFQMAQEKPPT.-ITATP-ap........
Q6EE25_SINCH/125-191             ..vs--VEKQLKDLMQDSQ----LPQFNETFLANLQGLKQQMNESEWKSFESWMRYWLIFQMAQQKPVP.-PTADPA..........
B4DUJ2_HUMAN/48-119              ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTDAPP..........
Q9MXD5_HORSE/120-191             ....NTTQDHVMHLLLRADPLKVYPQLKGSFQENLKHLKSTMDGLDWKVFENWMHQWLLFEMSRNSLEE.KPTQGP-t.........
A5A6L4_PANTR/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
G1KQJ0_ANOCA/133-204             ....NSTEDQVKRVLLRENPLRKFPEFNSSFIENIGQMRFRMDYEDWKAFETWMHKWLLFQMAQNAIPE.EKEDVP-l.........
Q3U4Q8_MOUSE/119-190             ....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEkKPTEAPP..........
G3HS40_CRIGR/166-236             ....NMTQDHVMHLLLRSGPLD-YPKLKGSFPENLKHLKNSMDGLNWKVFESWMKQWLLFEMSKNSLEE.KPTEAPP..........
G3X0Q6_SARHA/117-189             ....NNTKDQVKYLLLQSDPRRSFPELTKSFQENMKKLKNNMETKNWKNFENWMHQWLLFEMSKKPNEE.NVE----kktep.....
Q2KM23_ANAPL/20-91               ....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
G9C7P1_CAIMO/123-194             ....NKTEDQVRHLLLQADPKKMFPELKDSLLDNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPD.ERKAIPA..........
G1RHC0_NOMLE/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
HG2A_HUMAN/136-207               ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTDAPP..........
#=GR HG2A_HUMAN/136-207    SS    ....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS-.-----S-..........
F7E9S4_MACMU/134-205             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQ.KPTEAPP..........
Q6GT70_RAT/120-191               ....NMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEkQPTQTP-p.........
H0YBZ2_HUMAN/131-202             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTDAPP..........
Q8JFN4_ONCMY/128-194             ...s--LEEQVKNLLQNPQ----LPQFNETFLANLQSLKKQVEETEWEGFETWARYWLLFQMAQEKPPV.LPTP---qpv.......
G1LDD9_AILME/136-206             ....NMTQDHVMHMLLEADPLKVYPKLKGSFPENLKHLKRTMETLDWKVFENWMYQWLLFEMSKNSLED.KPE----vpl.......
F7E6Z5_XENTR/99-170              ....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNT---.-------gifieaqtqr
B6VAR1_EPIAK/127-197             ..vs--VEAQLKELLQEDS---QLPQFNETFLANLQGMKQHVNETDWKSFESWMRYWLIFQIAQRTPAP.-PTAEP-ttap......
I0FWR4_MACMU/134-205             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQ.KPTEAPP..........
H2QRT2_PANTR/136-207             ....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ.KPTEAPP..........
#=GC SS_cons                     ....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS-.-----S-..........
#=GC seq_cons                    ....NhTEDpVhHLLhpuDPhKhaPpLKsoF.-NL++LKpoMpshDWKsFEoWMHpWLLFEMu+pshpp.cPTthP...........
//
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