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Database: Pfam
Entry: MHCassoc_trimer
LinkDB: MHCassoc_trimer
Original site: MHCassoc_trimer 
#=GF ID   MHCassoc_trimer
#=GF AC   PF08831.8
#=GF DE   Class II MHC-associated invariant chain trimerisation domain
#=GF AU   Mistry J
#=GF SE   pdb_1iie
#=GF GA   25.00 25.00;
#=GF TC   35.40 58.10;
#=GF NC   24.80 18.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9843486
#=GF RT   Structure of a trimeric domain of the MHC class II-associated
#=GF RT   chaperonin and targeting protein Ii. 
#=GF RA   Jasanoff A, Wagner G, Wiley DC; 
#=GF RL   EMBO J. 1998;17:6812-6818.
#=GF DR   INTERPRO; IPR011988;
#=GF DR   SCOP; 1iie; sf;
#=GF CC   The class II associated invariant chain peptide is required for
#=GF CC   folding and localisation of MHC class II heterodimers.  This
#=GF CC   domain is involved in trimerisation of the ectoderm and
#=GF CC   interferes with DM/class II binding.  The trimeric protein forms
#=GF CC   a cylindrical shape which is thought to be important for
#=GF CC   interactions between the invariant chain and class II molecules
#=GF CC   [1].
#=GF SQ   66
#=GS A0A087XGP4_POEFO/127-190  AC A0A087XGP4.1
#=GS G3R7S6_GORGO/136-204      AC G3R7S6.1
#=GS K7E537_MONDO/116-184      AC K7E537.1
#=GS F6V5T6_CALJA/140-208      AC F6V5T6.1
#=GS F7E9S4_MACMU/134-202      AC F7E9S4.1
#=GS H0YRJ5_TAEGU/122-190      AC H0YRJ5.1
#=GS L9KN01_TUPCH/120-188      AC L9KN01.1
#=GS W5PBE0_SHEEP/134-202      AC W5PBE0.1
#=GS W5MYQ4_LEPOC/126-189      AC W5MYQ4.1
#=GS G1KQJ0_ANOCA/112-180      AC G1KQJ0.2
#=GS F7AJH7_ORNAN/117-185      AC F7AJH7.1
#=GS V8NV32_OPHHA/110-178      AC V8NV32.1
#=GS H2R586_PANTR/136-204      AC H2R586.1
#=GS G1QEN4_MYOLU/120-188      AC G1QEN4.1
#=GS G3TJE1_LOXAF/120-188      AC G3TJE1.1
#=GS H2LJJ2_ORYLA/123-187      AC H2LJJ2.1
#=GS M3YQS4_MUSPF/120-188      AC M3YQS4.1
#=GS M4A2I1_XIPMA/126-189      AC M4A2I1.1
#=GS M3VXS2_FELCA/120-188      AC M3VXS2.1
#=GS Q5RFJ4_PONAB/136-204      AC Q5RFJ4.1
#=GS F6ZRD0_XENTR/125-192      AC F6ZRD0.1
#=GS G1SKK3_RABIT/135-203      AC G1SKK3.2
#=GS HG2A_MOUSE/119-187        AC P04441.3
#=GS Q29630_BOVIN/118-186      AC Q29630.1
#=GS F1NYL5_CHICK/124-192      AC F1NYL5.1
#=GS G3HS40_CRIGR/166-233      AC G3HS40.1
#=GS HG2A_HUMAN/136-204        AC P04233.3
#=GS HG2A_HUMAN/136-204        DR PDB; 1IIE A; 120-188;
#=GS HG2A_HUMAN/136-204        DR PDB; 1IIE C; 120-188;
#=GS HG2A_HUMAN/136-204        DR PDB; 1IIE B; 120-188;
#=GS Q6J613_CHICK/124-192      AC Q6J613.1
#=GS HG2A_RAT/120-187          AC P10247.2
#=GS I3K5M3_ORENI/126-189      AC I3K5M3.1
#=GS G3Q1Q6_GASAC/122-186      AC G3Q1Q6.1
#=GS G7P8P8_MACFA/134-202      AC G7P8P8.1
#=GS U3K012_FICAL/120-188      AC U3K012.1
#=GS G3X0Q6_SARHA/117-186      AC G3X0Q6.1
#=GS G3Q1R2_GASAC/131-197      AC G3Q1R2.1
#=GS G3U7Y6_LOXAF/120-188      AC G3U7Y6.1
#=GS A0A091E9W3_FUKDA/120-188  AC A0A091E9W3.1
#=GS H2SNE4_TAKRU/125-188      AC H2SNE4.1
#=GS H0YBZ2_HUMAN/131-199      AC H0YBZ2.1
#=GS H2QRT2_PANTR/136-204      AC H2QRT2.1
#=GS A0A0P7UQQ6_9TELE/121-185  AC A0A0P7UQQ6.1
#=GS G1RHB8_NOMLE/136-204      AC G1RHB8.1
#=GS S9XLT6_9CETA/118-186      AC S9XLT6.1
#=GS F6TGS3_HORSE/120-188      AC F6TGS3.1
#=GS F7ENE8_CALJA/140-208      AC F7ENE8.1
#=GS H3B8G7_LATCH/132-199      AC H3B8G7.1
#=GS M7AY47_CHEMY/285-353      AC M7AY47.1
#=GS F7ENE3_CALJA/136-204      AC F7ENE3.1
#=GS G5C391_HETGA/121-189      AC G5C391.1
#=GS E2RF90_CANLF/136-204      AC E2RF90.2
#=GS H3D9Q2_TETNG/125-189      AC H3D9Q2.1
#=GS A0A096MM48_PAPAN/134-202  AC A0A096MM48.1
#=GS L5LQM9_MYODS/120-188      AC L5LQM9.1
#=GS G1N4A4_MELGA/101-168      AC G1N4A4.2
#=GS H0WQB3_OTOGA/120-188      AC H0WQB3.1
#=GS F6VER1_CALJA/48-116       AC F6VER1.1
#=GS G3USV8_MELGA/101-168      AC G3USV8.1
#=GS F7ENM4_CALJA/135-203      AC F7ENM4.1
#=GS L5L1G3_PTEAL/120-188      AC L5L1G3.1
#=GS F7E6Z5_XENTR/99-167       AC F7E6Z5.1
#=GS A0A0D9RGK4_CHLSB/134-202  AC A0A0D9RGK4.1
#=GS H0UZ94_CAVPO/120-188      AC H0UZ94.1
#=GS U3J8L0_ANAPL/102-170      AC U3J8L0.1
#=GS W5MYP5_LEPOC/126-189      AC W5MYP5.1
#=GS I3MCR9_ICTTR/119-187      AC I3MCR9.1
#=GS G1LDD9_AILME/136-204      AC G1LDD9.1
A0A087XGP4_POEFO/127-190             ....v-SVEKQVMDMMKDVS----LPQFNETFLANLRSLQQQINESEWKNFESWMRYWLIFQMAQQKP------agptp..
G3R7S6_GORGO/136-204                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
K7E537_MONDO/116-184                 .....NSTTDQVKYLLQRSDPRRSFPDLTKSFQENLKHLKSNMDPKNWKTFENWMHQWLLFEMSKKPKEEKTE-t......
F6V5T6_CALJA/140-208                 .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
F7E9S4_MACMU/134-202                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
H0YRJ5_TAEGU/122-190                 .....NKTEDLVKHVLLQADPSKMFPELKDNLMDNLKRLRSTMTHVDWKSFESWMHKWLLFEMAKNPQSEDRK-a......
L9KN01_TUPCH/120-188                 .....NMTQDHVMHLLLKADPLKVYPQLKGSFPENLKHLKSTMETMDWKVFESWMHQWLLFEMSKNSMEEKPTE.......
W5PBE0_SHEEP/134-202                 .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFENWLHQWLLFEMSKNSLEEKPF-e......
W5MYQ4_LEPOC/126-189                 ...vs--LEKQVKDLLQDEN----LPQFNETFLGNLQGMKSQMEDSEWKSFESWMRSWLIFQMAQQQPPK----ptp....
G1KQJ0_ANOCA/112-180                 .....NSTEDQVKRVLLRENPLRKFPEFNSSFIENIGQMRFRMDYEDWKAFETWMHKWLLFQMAQNAIPEEK--vk.....
F7AJH7_ORNAN/117-185                 .....NSTTDQVMHLLLKGAPTKIYPELNEGFQDNMEQLKNNMGHESWQNFKHWMHHWLLFELSKKPQNAAPT-e......
V8NV32_OPHHA/110-178                 .....NSTEDQVKRLLLRENPTRTFPELKSTFQENMGHLKIRMPYNDWKEFETWMHKWLIFQMAQKQNTEEK--gk.....
H2R586_PANTR/136-204                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
G1QEN4_MYOLU/120-188                 .....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGEKL--te.....
G3TJE1_LOXAF/120-188                 .....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEEKPTE.......
H2LJJ2_ORYLA/123-187                 ....v-SVEKQLMDLMQDFS----LPKFNETFQANLETLRQQVNESEWQTFETWMRYWLIFQMAQKQPPA----ptpq...
M3YQS4_MUSPF/120-188                 .....NMTQDHVMHVLLETDPLKVYPKLKGSFLENLKHLKNTMGPLEWKVFESWMYQWLLFEMSKNSLENKPE-v......
M4A2I1_XIPMA/126-189                 ....v-SVEKQVMDMMKDIS----LPQFNETFLANLRSLKQQFNDSEWKSFESWMRYWLIFQMAQQEP------agptp..
M3VXS2_FELCA/120-188                 .....NMTQDHVMHMLLEGDPLKVYPQLKGNFPENLKHLKNTMGTLDWKVFENWMYQWLLFEMSKNSLEKHPA-d......
Q5RFJ4_PONAB/136-204                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
F6ZRD0_XENTR/125-192                 .....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNTGKA----aep....
G1SKK3_RABIT/135-203                 .....NTTQDYVMHLLLRSDPLKVYPQLKGSFPENLKQLKGTMDGLNWKVFESWLHQWLLFEMSKNSLEEKPTE.......
HG2A_MOUSE/119-187                   .....NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKK--pte....
Q29630_BOVIN/118-186                 .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEEKPF-e......
F1NYL5_CHICK/124-192                 .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
G3HS40_CRIGR/166-233                 .....NMTQDHVMHLLLRSGPLD-YPKLKGSFPENLKHLKNSMDGLNWKVFESWMKQWLLFEMSKNSLEEKPTE.......
HG2A_HUMAN/136-204                   .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
#=GR HG2A_HUMAN/136-204        SS    .....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS------......
Q6J613_CHICK/124-192                 .....NKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQN-t......
HG2A_RAT/120-187                     .....NMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQ--pt.....
I3K5M3_ORENI/126-189                 ....v-SVEKQLMDLMQDSE----LPQFNETFLANLQTLKQHMNDSEWKSFETWMRYWLIFKMAQQQPA-----tptp...
G3Q1Q6_GASAC/122-186                 ...vs--LETQVKNLMQGSQ----LPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPP-----tptpq..
G7P8P8_MACFA/134-202                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
U3K012_FICAL/120-188                 .....NKTEDQVKHLLLQADPSKMFPELRDNLMDNLKRLRSTMTHADWKSFESWMHKWLLFEMAKNPKSEDRK-a......
G3X0Q6_SARHA/117-186                 .....NNTKDQVKYLLLQSDPRRSFPELTKSFQENMKKLKNNMETKNWKNFENWMHQWLLFEMSKKPNEENV--ekk....
G3Q1R2_GASAC/131-197                 ...gl---ETQVKNLMQ-VGPRVLLPQFNETFLANLQSLKQHVNESEWTSFESWMRYWLIFQMAQQNPP-----tptpq..
G3U7Y6_LOXAF/120-188                 .....NMPQDYVMHMLLRTDPLKVYPQLKGTLPENLKHLKNTMDGLDWKAFENWMHQWLLFEMSKNSVEEKPTE.......
A0A091E9W3_FUKDA/120-188             .....NMTQDHVMHTLLQSDPLKVYPQLTGSFLENLKHLKNTMQSLDWKVFESWMHHWLLFEMSRNSPEK----ptea...
H2SNE4_TAKRU/125-188                 ....v-SVETQVKDLLQDFK----LPLFNSTFIPNLLALKQQMNETVWEEFESWMQFWLIFQMAQEKA------pllta..
H0YBZ2_HUMAN/131-199                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPT-d......
H2QRT2_PANTR/136-204                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
A0A0P7UQQ6_9TELE/121-185             ...vn--VETQVKELLQGQD----LPQFNETFLSNLKALKSQMEESEWKGFESWMHHWLIFQMAQQAPPK----ptad...
G1RHB8_NOMLE/136-204                 .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTE.......
S9XLT6_9CETA/118-186                 .....NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKNTMDGMNWKLFENWMHYWLLFEMSKNSQEEQP--fe.....
F6TGS3_HORSE/120-188                 .....NTTQDHVMHLLLRADPLKVYPQLKGSFQENLKHLKSTMDGLDWKVFENWMHQWLLFEMSRNSLEEKPT-q......
F7ENE8_CALJA/140-208                 .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
H3B8G7_LATCH/132-199                 vdimg-----QVLEML-QQNPQLAFPNMTGNFLENLNGLKEQMQKPNWQEFESWLQHWFLFQLVQKQSQP----qsva...
M7AY47_CHEMY/285-353                 .....NSTTDQVKHLLLRADPSKMFPELKNNLMENLNHLKHTMTNQDWQSFESWMHKWLLFEMAKTPQTVQPT-e......
F7ENE3_CALJA/136-204                 .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
G5C391_HETGA/121-189                 .....NMTQDHVMHMLLKSDPLKVYPQLEGSFLDNLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPGEKPT-e......
E2RF90_CANLF/136-204                 .....NMTQDHVMHLLLEADPLKVYPKLKGSFPENLKHLKNTMETLDWKVFENWMYQWLLFEMSKNSLEKKST-e......
H3D9Q2_TETNG/125-189                 ....v-SVETQVKDLLQNFT----LPAFNSTFASNLLALKSQMDQTTWQKLESWMQSWLIFQMAQEKPP-----titat..
A0A096MM48_PAPAN/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
L5LQM9_MYODS/120-188                 .....NTTMDHVMHLLLKADPLKVYPQMKGSFPENLKHLKKTMEGLDWKIFESWMHQWLLFEMSKNSLGEKL--te.....
G1N4A4_MELGA/101-168                 .....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEEQ---na.....
H0WQB3_OTOGA/120-188                 .....NMTQDHVMHLLLKADPLKVYPQMKGNFPENLKHLKSTMETLDWKVFESWMHQWLLFEMSKNSGEEKPTE.......
F6VER1_CALJA/48-116                  .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
G3USV8_MELGA/101-168                 .....NKTEDQVRHLLLKADPRKTFPELKDDMLGNMKRLQKTMSAMDWKDFEAWMHKWLLFEMAKSPKEEQ---na.....
F7ENM4_CALJA/135-203                 .....NMTEDHVMHLLLNADPLKVYPPLKGSLSENLKHLKNTMETMDWKVFESWLHHWLLFEMSKHSLEQKPTE.......
L5L1G3_PTEAL/120-188                 .....NSTLDHVMHLLLKSDPLKVYPQLKGSFPENLKRLRNTMEGLDWKAFENWMHQWLLFEMSKNSLEEKPK-p......
F7E6Z5_XENTR/99-167                  .....NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNT-------gifieaq
A0A0D9RGK4_CHLSB/134-202             .....NMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKSTMETLDWKVFESWMHHWLLFEMSKHSLEQKPTE.......
H0UZ94_CAVPO/120-188                 .....NTTQDYVMHTLLKSDPLKVYPQLQGSFLENLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPEEKPTE.......
U3J8L0_ANAPL/102-170                 .....NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPDERK-a......
W5MYP5_LEPOC/126-189                 ...vs--LEKQVKDLLQDEN----LPQFNETFLGNLQGMKSQMEDSEWKSFESWMRSWLIFQMAQQQPPK----ptp....
I3MCR9_ICTTR/119-187                 .....NMTQDHVMHLLLKSNPLKVYPQLKGSFPENLKHLKSTMDNLDWKIFENWLHQWLLFEMSKNSLEEKPTE.......
G1LDD9_AILME/136-204                 .....NMTQDHVMHMLLEADPLKVYPKLKGSFPENLKHLKRTMETLDWKVFENWMYQWLLFEMSKNSLEDKPE-v......
#=GC SS_cons                         .....SS-HHHHHHHHHHH-TT-------S-HHHHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHT--SS------......
#=GC seq_cons                        .....NhTpDpVMHLLLcuDPLKsYPpLKGoF.ENL+HLKsTM-shDWKsFESWMHpWLLFEMS+pohEpc..........
//
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