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Database: Pfam
Entry: MLANA
LinkDB: MLANA
Original site: MLANA 
#=GF ID   MLANA
#=GF AC   PF14991.3
#=GF DE   Protein melan-A
#=GF AU   Bateman A
#=GF SE   Jackhmmer:Q16655
#=GF GA   27.00 27.00;
#=GF TC   27.20 73.20;
#=GF NC   24.70 23.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   MLANA
#=GF RN   [1]
#=GF RM   8170938
#=GF RT   Cloning of the gene coding for a shared human melanoma antigen
#=GF RT   recognized by autologous T cells infiltrating into tumor.
#=GF RA   Kawakami Y, Eliyahu S, Delgado CH, Robbins PF, Rivoltini L,
#=GF RA   Topalian SL, Miki T, Rosenberg SA;
#=GF RL   Proc Natl Acad Sci U S A. 1994;91:3515-3519.
#=GF RN   [2]
#=GF RM   8006593
#=GF RT   A new gene coding for a differentiation antigen recognized by
#=GF RT   autologous cytolytic T lymphocytes on HLA-A2 melanomas.
#=GF RA   Coulie PG, Brichard V, Van Pel A, Wolfel T, Schneider J,
#=GF RA   Traversari C, Mattei S, De Plaen E, Lurquin C, Szikora JP,
#=GF RA   Renauld JC, Boon T;
#=GF RL   J Exp Med. 1994;180:35-42.
#=GF RN   [3]
#=GF RM   19717472
#=GF RT   The ocular albinism type 1 (OA1) G-protein-coupled receptor
#=GF RT   functions with MART-1 at early stages of melanogenesis to
#=GF RT   control melanosome identity and composition.
#=GF RA   Giordano F, Bonetti C, Surace EM, Marigo V, Raposo G;
#=GF RL   Hum Mol Genet. 2009;18:4530-4545.
#=GF DR   INTERPRO; IPR029242;
#=GF SQ   45
#=GS A0A0D9R980_CHLSB/2-118   AC A0A0D9R980.1
#=GS F7G2A4_MACMU/2-118       AC F7G2A4.1
#=GS U3I7Z8_ANAPL/2-113       AC U3I7Z8.1
#=GS G5B6S2_HETGA/2-118       AC G5B6S2.1
#=GS G1QEN9_MYOLU/1-95        AC G1QEN9.1
#=GS U3K7R0_FICAL/2-113       AC U3K7R0.1
#=GS F6PMG8_CANFA/2-118       AC F6PMG8.1
#=GS W5PVS9_SHEEP/2-118       AC W5PVS9.1
#=GS MAR1_HUMAN/2-118         AC Q16655.1
#=GS MAR1_HUMAN/2-118         DR PDB; 2GTZ F; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 3QDM C; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GUO C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4WJ5 C; 1-8;
#=GS MAR1_HUMAN/2-118         DR PDB; 3MRQ P; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GTW C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GTZ C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 3L6F C; 1-15;
#=GS MAR1_HUMAN/2-118         DR PDB; 3QEQ C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4QOK C; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 3HG1 C; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GTW F; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4WJ5 F; 1-8;
#=GS MAR1_HUMAN/2-118         DR PDB; 4EUP C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4EUP F; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4JFF C; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GT9 F; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 3MRO P; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GT9 C; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 2GUO F; 1-9;
#=GS MAR1_HUMAN/2-118         DR PDB; 4L3E C; 1-10;
#=GS MAR1_HUMAN/2-118         DR PDB; 3MRP P; 1-10;
#=GS G3VV60_SARHA/2-98        AC G3VV60.1
#=GS F1SMM1_PIG/2-118         AC F1SMM1.2
#=GS F6QDI3_MONDO/2-119       AC F6QDI3.1
#=GS G3RJG3_GORGO/2-118       AC G3RJG3.1
#=GS F6Y2L7_HORSE/2-118       AC F6Y2L7.1
#=GS G1RCY2_NOMLE/2-118       AC G1RCY2.1
#=GS L5K942_PTEAL/16-89       AC L5K942.1
#=GS G7PSE2_MACFA/2-118       AC G7PSE2.1
#=GS F6QH78_CALJA/2-118       AC F6QH78.1
#=GS H0X3V0_OTOGA/2-118       AC H0X3V0.1
#=GS G1TBP4_RABIT/3-119       AC G1TBP4.2
#=GS M3YAE2_MUSPF/2-118       AC M3YAE2.1
#=GS H3CUG6_TETNG/2-112       AC H3CUG6.1
#=GS A0A087YPI6_POEFO/10-120  AC A0A087YPI6.1
#=GS H2QX01_PANTR/2-118       AC H2QX01.1
#=GS W5MVB6_LEPOC/2-119       AC W5MVB6.1
#=GS W5LFV3_ASTMX/2-118       AC W5LFV3.1
#=GS M7AY78_CHEMY/32-112      AC M7AY78.1
#=GS G1L271_AILME/1-95        AC G1L271.1
#=GS G1KCI6_ANOCA/2-114       AC G1KCI6.2
#=GS G3PX89_GASAC/2-113       AC G3PX89.1
#=GS F1MXK9_BOVIN/2-118       AC F1MXK9.2
#=GS H2LTQ3_ORYLA/10-120      AC H2LTQ3.1
#=GS L5M0K4_MYODS/69-177      AC L5M0K4.1
#=GS G1N196_MELGA/2-120       AC G1N196.1
#=GS Q2TA50_MOUSE/2-113       AC Q2TA50.1
#=GS G3UD84_LOXAF/2-57        AC G3UD84.1
#=GS L9KKQ8_TUPCH/28-102      AC L9KKQ8.1
#=GS H0VNR1_CAVPO/2-118       AC H0VNR1.1
#=GS W5MVA7_LEPOC/9-122       AC W5MVA7.1
#=GS H2PS70_PONAB/2-118       AC H2PS70.1
#=GS E1C403_CHICK/2-113       AC E1C403.1
#=GS H1A4V7_TAEGU/2-118       AC H1A4V7.1
#=GS M3ZSI7_XIPMA/2-113       AC M3ZSI7.1
#=GS A0A096P1K5_PAPAN/2-118   AC A0A096P1K5.1
#=GS D3ZWI9_RAT/2-116         AC D3ZWI9.1
A0A0D9R980_CHLSB/2-118              .................PREDAHFIYGYPKkGHGH.SYITAEEAAGIGVLTVILGILLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHQNSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
F7G2A4_MACMU/2-118                  .................PREDAHFIYGYPKkGHGH.SYITAEEAAGIGILTVILGILLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHQDSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
U3I7Z8_ANAPL/2-113                  .................PRRNHHPDGNFFR.GKGH.SYLALEEALGIGIFFLVLAMLFIFGCWYYKRCSGYKSLRSKSTS.....MGTIRTVVGEGRIV..DC.-----KMALQEY.RNFDSVVPDAPPAYEKI.DADQLPPPYSP................
G5B6S2_HETGA/2-118                  .................PQEEGHFSHGYPRkGHGH.AYITTEEAAGIGILTVILGILLLIGCWYCRRQSGYRTLMDKNLH.....AGVQGTLCRRCSHE..EL.GHQDTKLFFQEK.-NCEPLVPNAPPAYEKL.SREQSPPPYSP................
G1QEN9_MYOLU/1-95                   ................g----------YPRrGHGH.SYITAKEIAGIGVLTVILGLVLFLGCWYCRRRNGYGILKGRSRY.....VGTQGTFTGRCLRE..GL.GHQDSKLPFLEN.-NYEPVVPNAPPAYE--.-----------................
U3K7R0_FICAL/2-113                  .................PRRNNHQDGNYFR.GKGH.IYFAAEEALGIGLFILVLAILLAFGCWYYKRRSGYKSLRSKSSS.....VSTIRNVVGEGEIL..EC.-----KMALQDY.KDFNSVVPDAPPAYEKI.AADLSPPPYSP................
F6PMG8_CANFA/2-118                  .................PREEAHFILGYPKkGHNH.SYITAEEAAGIGILTVILGILLLIACWYCRRRSGYRSLRDKSIH.....AGTQSTLRGRCPHE..GF.GHQHSKLPFQES.-NCELVVPNAPPAYEKL.SAEQSSPPYLP................
W5PVS9_SHEEP/2-118                  .................PREEVHFFYGSPRkGHSH.SYVTTEEAAGIGILTVILGILLLLSCWYCRRRSGYRSLKDKNIH.....AGTPSTLTGGCSHE..WL.GQQDSKLPFQEN.-NCEPVIPNAPPAYEKL.SAEQSPPPYSP................
MAR1_HUMAN/2-118                    .................PREDAHFIYGYPKkGHGH.SYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHRDSKVSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
#=GR MAR1_HUMAN/2-118         SS    .................XXXXXXX---SSSBE--X.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXX..BX.XXXXXXXXXXXX.-XXXXXXXXXXXXXXXX.XXXXXXXXXXX................
G3VV60_SARHA/2-98                   .................PKENDHFIHAYLK.KKKI.PHLMAEEAAGIGILAVILGVLLLLTCWYCKRRSGYKILKDKKLG.....AGTGNALMGNYYQD..KG.ILPVSKGPFQEN.NNYNSMV----------.-----------c...............
F1SMM1_PIG/2-118                    .................PREEAHFFYGSSKkGHGH.SHITAEEAAGIGFLMVILGILLLISCWYCKRRSGYRSLKDKSIH.....DSTKSTLTRRCSHE..GI.GHQDSKLSFQEN.-NCGPVVPNAPPAYEKF.STEQSPPPYFP................
F6QDI3_MONDO/2-119                  ................t-KENAHFIDVYFKkKKSS.SHITAEEAVGIGILAVILGILLLISCWYCRRRSGYKTLKDKNLC.....VGTQNALMGNYYSD..ES.VLPVNKMPFQEN.SNCNSVVPDAPPAYEKL.PAEQFPPPYTP................
G3RJG3_GORGO/2-118                  .................PREDAHFIYGYPKkGHGH.SYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHRDSKVSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
F6Y2L7_HORSE/2-118                  .................PREEAYFTYGYPKmGHGR.SHITAEEAAGIGILIVILGILLLIGCWYCRRRSGYKSLKDKSIY.....VSTQSTLTGRCPRE..GL.GHQDSKLPFQEN.-SCDPVVPNAPPAYEKL.SATQSPPPYSP................
G1RCY2_NOMLE/2-118                  .................PREDAHFIYDYPKkRHGH.SYITAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLH.....VGTQCDLTRRCPQE..GF.DHRDSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
L5K942_PTEAL/16-89                  ....tkvscqraseheg-------------.----.--------------------------------------QDKSLH.....AGTPSTLIGRCTCE..GL.GHQDSKLPFQEN.-NCEFVVPNAPPAYEKV.SAEQSPPPYSP................
G7PSE2_MACFA/2-118                  .................PREDAHFIYGYPKkGHGH.SYITAEEAAGIGILTVILGILLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHQDSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
F6QH78_CALJA/2-118                  .................PREDTPFVSDYPRkRHGH.SYITAEEAAGIGILTVILGIILLIGCWYCRRRNGYRALMDKSLH.....AGTQNTLTRRCPQE..GY.GHQDSKLSFQEK.-NCEHVVPNAPPAYEKL.SAEQSPPPYSP................
H0X3V0_OTOGA/2-118                  .................PREDAHFVYGNPKkGHHH.SYITAEEAAGIGILTVILGILLLIGCWYCRRRSGYRTLTDKNHH.....VGSQSTLTRRCSRE..GL.GHQDSKLPFQER.-NCDLVVPNAPSSYEKL.STEQSPPPYSP................
G1TBP4_RABIT/3-119                  .................PRKEAHFIYGYPKkGHGH.SYITVEEAAGIGILTVILGVLLLIGCWYCRRRSGYRTLTDKSLQ.....AGIQSTLMGRGPQE..QL.GQQDSNLFFQEK.-NCELLVPNAPPAYEKV.SAEQSPPPYSP................
M3YAE2_MUSPF/2-118                  ................s-REEVHFILGYPKkGHNH.SYITAEEAAGIGILTMILGVLLLIGCCYWRRQSGYRSLRDKGIH.....AGIQSILTGRCSSE..GF.GHQDSKLPFQEN.-NCEPVVADAAPAYEKL.SIEKSPPPYS-s...............
H3CUG6_TETNG/2-112                  .................PRGDFNI---YFA.SNRH.GYVRAEEAVGIVLLLVILAAVFVLSCWYFKKRSGYKLISS----.....IRSGSPGYTGGQYS..EAgPAAESKMAMTDF.GSFRPAVPNAPPAYEKI.ASGPLPPPYSP................
A0A087YPI6_POEFO/10-120             .................PRGDFNV---YFA.SGRR.GYVRAEEAVGIGLLVVVLAGLFILGCWYLKKRSGYKIIRSV---.....-GSGSAGFTGGQYS..EPgTSADNKMSLSDF.GSFRSVVPNAPPAYEKI.SSGPLPPPYSP................
H2QX01_PANTR/2-118                  .................PREDAHFIYGYPKkGHGH.SYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHRDSKVSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
W5MVB6_LEPOC/2-119                  .................PRGEFTVQFSSRG.TGGG.SYVRAEEAAGIALLVIILAALLIIGCWYYKRRRGYKSIRSQGLD.....RSSFRSLMKSDHYS..EEgASAENKVVLSEF.HNLNSVVPSAPPPYEKI.ASGPSPPPYS-a...............
W5LFV3_ASTMX/2-118                  .................PRGDFNV---HFA.SRGRgSYIRAEEAAGIALLAIILTALLILGCWYYRRRNGYKMIRNSRGT.....SQSWRDIMRSGQYS..EPgAAAENKVALNEF.SNLQPALPNAPPAYEKIaASGPLPPPYSP................
M7AY78_CHEMY/32-112                 .................PKGDHQTDGIFSR.GKRY.TYLAAQEAAGIGILVVVLAVLLIIGCWYYKRRCGYKNLRRERLR.....ACLH----------..--.------------.-----------------.-----------ypldrssdrssggtrg
G1L271_AILME/1-95                   .............ghpk------------K.GHNH.SYITAEEAAGIGILTVILGSLLLIGCWYCRRRSEYRSLRDKSIH.....AGTQSTLTGRCPCE..GF.GHQDSKLPFQEN.-NCEPVVPSAPPAYE--.-----------................
G1KCI6_ANOCA/2-114                  .................PKGDHYLDGSFGR.GKRF.TSLSTEEAAGIGLLVVVLAALLLIGCWYYKKRRGYRNLLSKNFK.....MTTMKTSEGKSALL..GS.-----KLSLQEYnSNYTQAVPDAPPAYDKI.STSPLPPPYAP................
G3PX89_GASAC/2-113                  .................PRGDFNI---YFA.SSRR.GYIRAEEAVGIVLLVVILASLLILGCWYFKKRSGYKIIRQS---.....PRSGTPSHTEGQYS..EAgPSADNKMAATDF.GSFRPTVANAPPAYDKI.SSGPLPPPYSP................
F1MXK9_BOVIN/2-118                  .................PREEAHFFYGSPRkGHSH.SYVTAEEAAGIGILIVILGILLLLSCWYCRRRSGYRSLKDKNIH.....AGTQSTLTGRCSHE..GL.GQQDSKLPFQEN.-NCEPVIPNAPPAYEKL.SAEQSPPPYSP................
H2LTQ3_ORYLA/10-120                 .................PRGDFNI---YFT.SGRR.GNVRAEEAVGIALLVVLLAGLLILGCWYFKKRSGYKIIRTP---.....-RSGSPGYTGGHYS..EGgPSADNKMALTDF.GSFRPVVPNAPPAYEKI.SSAPLPPPYSP................
L5M0K4_MYODS/69-177                 kvqletafpksvdtesl-------------.----.-------IAGIGVLTVILGLVLFLGCWYCRRRNGYGTLKGKSRY.....VGTQGTFTGRCLRE..GL.GRQDSKLPFLEN.-NYEPVVPNAPPAYEKL.STQQSPPPYSP................
G1N196_MELGA/2-120                  .................PRGSDHQGGNFFR.GKGR.IYFTAEQALGIGIFILVLAILIIFGCWFYKRRSGYKRLRSKT-T.....FSLLKKFTSKNRCDwsKP.RKQKAQLSFQSFtLIFLPQVPDAPPAYDKI.AAEQSPPPYSP................
Q2TA50_MOUSE/2-113                  .................PQEDIHF--GYPRkGHRR.SYVTAEEAAGIGILIVVLGIALLIGCWYCRRRSGYRTLMDKRRH.....IGIQKTSRERCSCE..SP.DHQDSRLSSQEK.-SHQPVVPNAPPAYEKL.S---SPPPYSP................
G3UD84_LOXAF/2-57                   .................PREDVHLIHGYPRkGYHH.ASITAEEAVGVGILTVILGILLLLGCWYCRRRSGYQTL------.....--------------..--.------------.-----------------.-----------................
L9KKQ8_TUPCH/28-102                 .....nyffsftnlyef-------------.----.------------------------------------TFQDKSLH.....AGTQSALMGRSSHE..EV.YHQDSKLPFQEK.-NCQSAVPNAPPAYEKL.SAEQSPPPYSP................
H0VNR1_CAVPO/2-118                  .................PREESHLDYGFPRkGRDH.TYITIEAAAGIGILTVILGILLLLGCWYCRRRSGYRTLTDKSLH.....ARAQSILQGRCSHG..QL.GHQDTKLSSEEK.-NCEPLVPNAPPAYEKL.SGEHSPPPYSP................
W5MVA7_LEPOC/9-122                  .................PRGEFTVQFSSRG.TGGG.SYVRAEEAAGIALLVIILAALLIIGCWYYKRRRGYKSIRLL---.....-RTSLSLMKSDHYS..EEgASAENKVVLSEF.HNLNSVVPSAPPPYEKI.ASGPSPPPYS-a...............
H2PS70_PONAB/2-118                  .................PTEDAHFIYGYPKkGHGH.SYITAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHRDSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
E1C403_CHICK/2-113                  .................PRRSHYEDGNFFR.GKGR.TYFTAEEALGIGIFILVLVLLLIFGCWFYKRRSGYKRLRSKGIG.....MDTIRTVVGEGARA..AC.-----KTALQEY.RNFNSVVPNAPPAYDKI.AAEQSPPPYSP................
H1A4V7_TAEGU/2-118                  .................PRGHNHLDSNYVR.GKGY.VYFAAEEALGIGLFILVLAILLAFGCWYYKRRNGYKSLRVSVAThflscVSTIRNLVGEGEIL..DC.-----KMPLQNY.RDFNSVVPDAPPAYTKI.AADQSPPPYSP................
M3ZSI7_XIPMA/2-113                  .................PRGDFNI---YFA.SRRR.GYVRAEEAVGIGLLVVVLAGLFILGCWYLKKRSGYKILRQS---.....TGSGSAGFTGGQYS..EPgTSADNKMALADF.GSFRSVVPNAPPAYEKI.SSGPLPPPYSP................
A0A096P1K5_PAPAN/2-118              .................PREDAHFIYGYPKkGHGH.SYITAEEAAGIGILTVILGILLLIGCWYCRRRNGYRALMDKSLH.....VGTQCALTRRCPQE..GF.DHQDSKLSLQEK.-NCEPVVPNAPPAYEKL.SAEQSPPPYSP................
D3ZWI9_RAT/2-116                    .................PREEVHF--GYPRkGHSH.SYITAEEAAGIGILVVALGIALLIGCWYCRRRSGYRALTDKRRH.....AGTQNTSRERCLCE..SL.DHQDSRLSSQEK.-NHQPVVPNAPPAYEKL.SSDHSPPPYSP................
#=GC SS_cons                        .................XXXXXXX---SSSBE--X.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXX..BX.XXXXXXXXXXXX.-XXXXXXXXXXXXXXXX.XXXXXXXXXXX................
#=GC seq_cons                       .................PRc-sHh.hsYs+.G+u+.SYlTAEEAAGIGILsVILGlLLLlGCWYCRRRsGY+sLpDKslp.....sGTpssLpt+s.p-..th.sppDSKlshQEp..NhcsVVPNAPPAYEKl.Su-pSPPPYSP................
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