GenomeNet

Database: Pfam
Entry: MSP1_C
LinkDB: MSP1_C
Original site: MSP1_C 
#=GF ID   MSP1_C
#=GF AC   PF07462.9
#=GF DE   Merozoite surface protein 1 (MSP1) C-terminus
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_21542 (release 10.0)
#=GF GA   29.80 29.80;
#=GF TC   163.90 163.40;
#=GF NC   20.80 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12466500
#=GF RT   Mosaic organization and heterogeneity in frequency of allelic
#=GF RT   recombination of the Plasmodium vivax merozoite surface
#=GF RT   protein-1 locus. 
#=GF RA   Putaporntip C, Jongwutiwes S, Sakihama N, Ferreira MU, Kho WG,
#=GF RA   Kaneko A, Kanbara H, Hattori T, Tanabe K; 
#=GF RL   Proc Natl Acad Sci U S A 2002;99:16348-16353.
#=GF DR   INTERPRO; IPR010901;
#=GF CC   This family represents the C-terminal region of merozoite
#=GF CC   surface protein 1 (MSP1) which are found in a number of
#=GF CC   Plasmodium species. MSP-1 is a 200-kDa protein expressed on the
#=GF CC   surface of the P. vivax merozoite. MSP-1 of Plasmodium species
#=GF CC   is synthesised as a high-molecular-weight precursor and then
#=GF CC   processed into several fragments. At the time of red cell
#=GF CC   invasion by the merozoite, only the 19-kDa C-terminal fragment
#=GF CC   (MSP-119), which contains two epidermal growth factor-like
#=GF CC   domains, remains on the surface. Antibodies against MSP-119
#=GF CC   inhibit merozoite entry into red cells, and immunisation with
#=GF CC   MSP-119 protects monkeys from challenging infections. Hence,
#=GF CC   MSP-119 is considered a promising vaccine candidate [1].
#=GF SQ   17
#=GS W7AFH8_PLAVN/1031-1338     AC W7AFH8.1
#=GS A0A024VR46_PLAFA/953-1507  AC A0A024VR46.1
#=GS W7AFH8_PLAVN/1321-1549     AC W7AFH8.1
#=GS Q4XPN3_PLACH/1-132         AC Q4XPN3.1
#=GS A0A024W7K7_PLAFA/401-664   AC A0A024W7K7.1
#=GS A0A024W7X9_PLAFA/822-1107  AC A0A024W7X9.1
#=GS K6UUJ2_9APIC/1011-1622     AC K6UUJ2.1
#=GS Q4X6U4_PLACH/1-208         AC Q4X6U4.1
#=GS Q4XT02_PLACH/1-314         AC Q4XT02.1
#=GS Q8I0U8_PLAF7/981-1536      AC Q8I0U8.1
#=GS W7A8Y0_9APIC/997-1362      AC W7A8Y0.1
#=GS Q4Z273_PLABA/843-1376      AC Q4Z273.1
#=GS B3L2X8_PLAKH/1056-1647     AC B3L2X8.1
#=GS W7A8Y0_9APIC/1378-1612     AC W7A8Y0.1
#=GS A5K724_PLAVS/1001-1576     AC A5K724.1
#=GS MSP1_PLAYO/1058-1591       AC P13828.1
#=GS A0A024WQJ1_PLAFA/971-1525  AC A0A024WQJ1.1
W7AFH8_PLAVN/1031-1338                ..............qgts---VQAESEDEMFVDDFELDNFYKSYLQQVDGN.NTQFINFIKSKKELIKALTPEKVNQLYLDIAHLKELSEHYYNRYYKYKLKLERLYQKHEQITAANQKVREVSILKSRLLRRKKYINGTFYVLPGYANFFNKRREAEKQYVDNAIKNTDMLLKYYKARSKYFTSEAVPLKTLTKTSIDREANYLKIEKFRAYSRLELRLKKNINLGKERITYVSGGLHHVFEEFKELLENKGYIGKSNPENAPEVFKAFEQYKELLPK..gVTIPAPVVTPV......VTPPVA-PAADTTS-NPPAAVVPLTEG------.-----.---.................................----------------------------------...-----------.------------------------------------------------------------------------------------------------------------------------------------------------...........---------.....................-------------------------------------------eestkvvass..............................
A0A024VR46_PLAFA/953-1507             ..................NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPYNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRALSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTV......VTPP--QPDVTPSPLSVRVSGSSGSTKEETQIP.TSGSL.---.................................LTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDE..yLDQVVTGEAIS.VTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEFPssppt.tppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKNEAH........................................
W7AFH8_PLAVN/1321-1549                ..........avvplteg---------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-----------......---------------------------------.-----.---.................................--------------EESTKVVAS---SDNDDDDD...MDQIASAQSTE.TQVTDILDAFKNEGEYIYTKSLGNTYKSFKKHMLKEFSIITEDIIAGLNYKLEKRNDFLDVLSYELALFKDINTNKFVVKNPYQLLDNDKKDKQMVNLKYAIKGVSDDIETVTDGIAFFNKMIELYKPQLNAVNEQIAAIGKET...........N--ENDEKK.....................-KYAPIFEDLKGLYETILEGAKEFSELLQHKLENYKIEKAGF-d.......................................
Q4XPN3_PLACH/1-132                    ..................---------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-----------......---------------------------------.-----.---.................................----------------------------------...-----------.-------------------------------------------------------------LSYELALFKDINTNKFVVKNPYQLLDNDKKDKQMINLKYAIKGVTEDIETATDGIEFFNKMVELYKPQLNAVNEQIAAIEKET...........--TDKEEKK.....................-KYVPIFEDLKGLYETILNGAEEFSELLQHKLENYKIEKAGF-d.......................................
A0A024W7K7_PLAFA/401-664              ypngivyplpltdihnsl---------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-----------......---------------------------------.-----.---.................................------AADNDKNSYEDDSLVVLPIFGESEDNDE..yLDQVVTGEAIS.VTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEFPssppt.tppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAH........................................
A0A024W7X9_PLAFA/822-1107             ..................NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTV......VTPP--QPDVTPSPLSVR---------------.-----.---.................................----------------------------------...-----------.------------------------------------------------------------------------------------------------------------------------------------------------...........---------.....................-------------------------------------------nyn.....................................
K6UUJ2_9APIC/1011-1622                .............elavs--GSSEEEPE---VKIEELKNIYEKHLSQIDNY.NDYFKKFLESQKENITKMDDTQWKALGVEIEELKKKIQVSLDHYEKYKLKLDRFMKKKNKISNSKEQIKKLTSLKNKLQRRQNLLNNPTSVLKNYTVFFNKKREAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLERFRVLSRMEGRLGNNIDLEKENISYLSSGLHHVFTELKEIINNKRYSGNDHAKNTAAVKVALQAYQELLPK...VTTQEGASVPAggaapvVAAPAPVVAGPPAG----GAG--GAGAGPVEGPaAPGTVaPAGapgvaaggagaepapgavvpgagapeasvttpgETGETGVVAAQDYAEDYDKVIALPLFGNNDDDGDdkeADQVTMGEAES.EAPEIIVPQGINEYDVVYIKPLAGMYKTIKKQLENHVNALNTNIIDMLDSRLKKRNYFLDVLNSDLNPYKYSSSGEYIIKDPYKLLDLEKKKKLLGSYKYIGASVDKDMVTANDGLAYYQKMGDLYKKHLDEVNEQIKEVEANI...........NKQDAEIKKiesdtsktaqknqlnakkeelQKYLPFLSSIQKEYNTLVNKVHSYTDTLKKIINNCQIEKKETE........................................
Q4X6U4_PLACH/1-208                    .................m------------FVDDFEVDNFYKSYLQQVDGN.NTQFIDFIKSKKELINALTPEKVNQLYLDIAHLKELSEHYYNRYYKYKLKLERLYQKHEQIEAANQKVKEISVLKSRLLKRKKYINGTFYVLSGFANFFNKRREAEKQYVDNAIKNTDMLLKYYKARSKYFTSEAVPLKTLTKTSIDREANYLKIEKFRAYSRLELRLKKNINLGKERITYVSGGL-----------------------------------------...-----------......---------------------------------.-----.---.................................----------------------------------...-----------.------------------------------------------------------------------------------------------------------------------------------------------------...........---------.....................-------------------------------------------........................................
Q4XT02_PLACH/1-314                    ..................---------------------------------.---------------------------------------------KYKLKLERLYQKHEQIEAANQKVKEISVLKSRLLKRKKYINGTFYVLSGFANFFNKRREAEKQYVDNAIKNTDMLLKYYKARSKYFTSEAVPLKTLTKTSIDREANYLKIEKFRAYSRLELRLKKNINLGKERITYVSGGLHHVFEEFKELLKNKGYTGKTNPENAPEVIKAFEQYKELLPK...GATTPAPVVTP......AVAPAS-ATTTPADE-------PAAAAAAAAAP.ASGSAtTTG.................................-------------GENGTPVVANSDNDDDDDDDD...MDQIANAQSTD.GEVKDILDEFKSENEYIYTKSLGNTYKSFKKHMLKEFSMIKEDIITGLNYKLEKR-----------------------------------------------------------------------------------------...........---------.....................-------------------------------------------........................................
Q8I0U8_PLAF7/981-1536                 ..................NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTV......VTPP--QPDVTPSPLSVRVSGSSGSTKEETQIP.TSGSL.---.................................LTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDE..yLDQVVTGEAIS.VTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEKFpssppttppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAH........................................
W7A8Y0_9APIC/997-1362                 ...........ntvkanc-----DDKPEDLL---MQMEMIYEKHISEMDKY.NENFNKFLESKKQKITTMKDEEWKALGTEIEQLKKKIQVSLDHYGKYKLKLERFLKKKKKVTNTKGQIKGLTILKNKLERRKNLLNIPTSVLKNFTVFFNKKRESEKKEVENTLKNTDILLNYYKALAKYYMSEPFPLKTISEESLQKEDNYLNLKKFKVLSRMEGRLGDNIQLEKENISYLSSGLHHVFTELKEIIDNKKYSGNRTGTSSTSGNRRTSISGNTSS-...-STSSTRSTRS......NNS----RRGSRRG-SSRSSSWSTSIRRSPSSN.STISN.STGrs............................nnnNTRGRRRSRSNNNNNNN-----------------...-----------.------------------------------------------------------------------------------------------------------------------------------------------------...........---------.....................-------------------------------------------trrrrrsrsnnnnnnnnndtrrrrinnndnnnnnnnnntr
Q4Z273_PLABA/843-1376                 .................s-ITTRAESEEDIPADDFELDNLYKSYLQRIDGN.NTEFINFIKSKKELIKALTPEKVNQLYLEIAHLKELSEHYYDRYYKYKLKLERLYEKHEQIQVSNRQIRELSILKARLLKRKQNINGIFYILSGYVNFFNKRREADKQYVDNALKNNDMLLKYYKARIKYFTSEAVPLKTLTKASLDRETNYLKIEKFRAYSRLELRFKKNINLGKEKISYVSGGLYHVFEEFKELLKNKNYTGKTNPDTVPEVTNAFEQYKELLPKgvtASASPAAATTP......TSADAATQRATPESRSGSGSG-SGSVVSSTPEE.VARS-.GSG.................................----------------ENAVVSGSSVDDNDDDD-...IDQIASGQSEN.AQEKNILEAFKNESEYLYARSLGITYKSLKKHMIREFSTIKEDMTTGLNNKLQKRNDFLEVLNHELDLFKDLSTNKYVIRNPYQLLDNDKKDKQIVNLKYAAKGVNEDIETTADGIKFFNKMIELYKIQLAAVKEQIDAIEAAT...........--TDKDEKK.....................-KYVPIFEDLKGLYETILGQSEEYIEVLQNRLDSYKNEKTEFE........................................
B3L2X8_PLAKH/1056-1647                ..............gvtv----QASSEEEPETNIVNVEKIYEKHLSQMDKY.NDYFIKFLESQKEKITSMTEEQANALGAEIEALKKKVQVSLDHYGKYKLKLERFLEKKNKISNSKEHIKKLTSLKNKLERKLNFLNNPTSVLKNYIIFFNKKKEAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESLQKEDNYLNLEKFRVLSRMEGRLGNNINLEKENISYLSSGLHHVFTELKEIIKNKKYTGNDHAKNTTAVKEALQAYEELLPK...VATQT-ASLPP......VAPPAVVPPVVPEAEAEAEAEAEAEPATSTQPA.TADTA.APTqtpaaptqtpaepata.tattgetaaapaapapVEVQNAEVKAQEYGEDYDKVITLPLFGNDEDDVEdqeEKQIITGEAEN.AQPENIVPEGINEYEVVYIKPLAGMYKSIKKQLENHVAAFNTNITDMLDSRLKKRNYFLDVLDSELNPFKYSSSGEYIIKDPYKLLDLEQKKKLLGSYQYIGASVDKDLITAKDGMEYYNKMGELYKQHLEAVNAQIKEIEASVpge....qsqlNAQKEELK-.....................-KYLPFLNSIQKEYESLVNMAHTYKENLKKFINNCQIEKKETE........................................
W7A8Y0_9APIC/1378-1612                .............degyd---------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-----------......---------------------------------.-----.---.................................--------------------------EEEEENKE...ADQVTTGEDENqETPEVIVPPGINEYEVVYIKPLAGMYKTIKKQLENHVTALNTNITDMLDSRFKKRNYFLGVLNFDLNPFKYSSTGDNIIKDPYKLLDLEKKKKMLGGYNYIGMSIEKDLATANDGLAYYNKMNDLYKKQLDAVNKKIKEVEDEIkkip..dgepnA-------Atnnqli.........avkeesKSYLPFLNSIKKEYESLVSMVITYTNNLKKFINNFQIEKRETE........................................
A5K724_PLAVS/1001-1576                .................v-GGNSEEKPE---ADTAQVEKFYEKHLSQIDKY.NDYFQKFLESQKDEITKMDETKWKALGAEIEELKKKLQVSLDHYGKYKLKLERLLKKKNKISNSKDQIKKLTSLKNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLHHVLTELKEIIKNKKYSGNDHTKNIAAVKEALQAYQELIPK...VTTQEGASTTA......ATLPVTVPSAVPGGL--PGAGVPGAAAGLTPPP.PAGSVpATGpga...........................aagSTEENVAAKAQDYAEDYDKVIALPLFGNNDDDGE...EDQVTTGEAES.EAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLENHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGASIDMDLATANDGVTYYNKMGELYKTHLDGVKTEIKKVEDDI...........KKQDEELKKlgnvnsqdskknefiakkaelEKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAE........................................
MSP1_PLAYO/1058-1591                  ................gi--RSRAESEEDMPADDFELDNLYKSYLQQIDGN.NTEFINFIKSKKELIKALTPEKVNQLYLEIAHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFNKRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKKNINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKgvtVSTPAVAVTTT......LAADAP---ATPEG-AVPGAV-PGAVPGAVPGA.VPGAVpGSG.................................----------------TDTRVAGSSVDDNEDDD-...IYQIASGQSED.APEKDILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLSTNKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAET...........NDTNKEEKK.....................-KYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFE........................................
A0A024WQJ1_PLAFA/971-1525             ..................NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTV......VTPP--QPDVTPSPLSVRVSGSSGSTKEETQIP.TSGSL.---.................................LTELQQVVQSQNYDEEDDSLVVLPIFGESEDNDE..yLDQVVTGEAIS.VTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEFPssppt.tppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAH........................................
#=GC seq_cons                         .......................tp..p...hp.hph-phYcphLpp.Dt..Ns.h.pFlcSppc.Ipths.pphptL..-ItpLKch.ph.hshY.KYKLKL-RhhpK+pplttsp.pl+clo.LKppL.p+hp.lNssh.VLpsassFFNK++EAEht.s-NslcNTchLLKaYKuhsKYa.uEs.PLKTLoc.SlppEsNYhplEKFRshS+h-h+LtcNlpLtKcploalSuGLHHlhpEhKEllcNKtYoGpp.scss.tV.pAhptYpphlP.........shssss......ssss.....sssts.........ht....................................................................s.hls....sps-Dss.....cQlssupu.s..t.c.Ilsth.sE.-hlYhKsLushY+ohKKph.pph.hhp.sh.shLs.+hpKRp.FLtVLp.-L..FK..soscallcssapLLs.-pKpp.hhshpYhhtulppDl.hsp-GltaapKhhthYK.pLtulpp.Itt.ct................ptp.Kt......................KalPhhpslpt.Ypslls.hppa...Lpthlpshp.EKtth.........................................
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