GenomeNet

Database: Pfam
Entry: MSP1_C
LinkDB: MSP1_C
Original site: MSP1_C 
#=GF ID   MSP1_C
#=GF AC   PF07462.8
#=GF DE   Merozoite surface protein 1 (MSP1) C-terminus
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_21542 (release 10.0)
#=GF GA   29.80 29.80;
#=GF TC   163.90 163.40;
#=GF NC   20.30 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12466500
#=GF RT   Mosaic organization and heterogeneity in frequency of allelic
#=GF RT   recombination of the Plasmodium vivax merozoite surface
#=GF RT   protein-1 locus. 
#=GF RA   Putaporntip C, Jongwutiwes S, Sakihama N, Ferreira MU, Kho WG,
#=GF RA   Kaneko A, Kanbara H, Hattori T, Tanabe K; 
#=GF RL   Proc Natl Acad Sci U S A 2002;99:16348-16353.
#=GF DR   INTERPRO; IPR010901;
#=GF CC   This family represents the C-terminal region of merozoite
#=GF CC   surface protein 1 (MSP1) which are found in a number of
#=GF CC   Plasmodium species. MSP-1 is a 200-kDa protein expressed on the
#=GF CC   surface of the P. vivax merozoite. MSP-1 of Plasmodium species
#=GF CC   is synthesised as a high-molecular-weight precursor and then
#=GF CC   processed into several fragments. At the time of red cell
#=GF CC   invasion by the merozoite, only the 19-kDa C-terminal fragment
#=GF CC   (MSP-119), which contains two epidermal growth factor-like
#=GF CC   domains, remains on the surface. Antibodies against MSP-119
#=GF CC   inhibit merozoite entry into red cells, and immunisation with
#=GF CC   MSP-119 protects monkeys from challenging infections. Hence,
#=GF CC   MSP-119 is considered a promising vaccine candidate [1].
#=GF SQ   9
#=GS Q4Z273_PLABA/843-1376   AC Q4Z273.1
#=GS W7KFP9_PLAFO/981-1536   AC W7KFP9.1
#=GS Q4XPN3_PLACH/1-132      AC Q4XPN3.1
#=GS B3L2X8_PLAKH/1056-1647  AC B3L2X8.1
#=GS Q4XT02_PLACH/1-314      AC Q4XT02.1
#=GS Q4X6U4_PLACH/1-208      AC Q4X6U4.1
#=GS Q8I0U8_PLAF7/981-1536   AC Q8I0U8.1
#=GS A5K724_PLAVS/1001-1576  AC A5K724.1
#=GS MSP1_PLAYO/1058-1591    AC P13828.1
Q4Z273_PLABA/843-1376              ...s-ITTRAESEEDIPADDFELDNLYKSYLQRIDGN.NTEFINFIKSKKELIKALTPEKVNQLYLEIAHLKELSEHYYDRYYKYKLKLERLYEKHEQIQVSNRQIRELSILKARLLKRKQNINGIFYILSGYVNFFNKRREADKQYVDNALKNNDMLLKYYKARIKYFTSEAVPLKTLTKASLDRETNYLKIEKFRAYSRLELRFKKNINLGKEKISYVSGGLYHVFEEFKELLKNKNYTGKTNPDTVPEVTNAFEQYKELLPKgvtASASPAAATTPTSADAATQRATPESRSGSGSG-SGSVVSSTPEEVARS-.GSG................................----------------ENAVVSGSSVDDNDDDD-...IDQIASGQSENAQEKNILEAFKNESEYLYARSLGITYKSLKKHMIREFSTIKEDMTTGLNNKLQKRNDFLEVLNHELDLFKDLSTNKYVIRNPYQLLDNDKKDKQIVNLKYAAKGVNEDIETTADGIKFFNKMIELYKIQLAAVKEQIDAIEAAT...........--TDKDEKK.....................-KYVPIFEDLKGLYETILGQSEEYIEVLQNRLDSYKNEKTEFE.
W7KFP9_PLAFO/981-1536              ....NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTVVTPP--QPDVTPSPLSVRVSGSSGSTKEETQIPTSGSL.---................................LTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDE..yLDQVVTGEAISVTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEKFpssppttppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAH.
Q4XPN3_PLACH/1-132                 ....---------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-------------------------------------------------.---................................----------------------------------...------------------------------------------------------------------------LSYELALFKDINTNKFVVKNPYQLLDNDKKDKQMINLKYAIKGVTEDIETATDGIEFFNKMVELYKPQLNAVNEQIAAIEKET...........--TDKEEKK.....................-KYVPIFEDLKGLYETILNGAEEFSELLQHKLENYKIEKAGF-d
B3L2X8_PLAKH/1056-1647             gvtv----QASSEEEPETNIVNVEKIYEKHLSQMDKY.NDYFIKFLESQKEKITSMTEEQANALGAEIEALKKKVQVSLDHYGKYKLKLERFLEKKNKISNSKEHIKKLTSLKNKLERKLNFLNNPTSVLKNYIIFFNKKKEAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESLQKEDNYLNLEKFRVLSRMEGRLGNNINLEKENISYLSSGLHHVFTELKEIIKNKKYTGNDHAKNTTAVKEALQAYEELLPK...VATQT-ASLPPVAPPAVVPPVVPEAEAEAEAEAEAEPATSTQPATADTA.APTqtpaaptqtpaepatatattgetaaapaapapVEVQNAEVKAQEYGEDYDKVITLPLFGNDEDDVEdqeEKQIITGEAENAQPENIVPEGINEYEVVYIKPLAGMYKSIKKQLENHVAAFNTNITDMLDSRLKKRNYFLDVLDSELNPFKYSSSGEYIIKDPYKLLDLEQKKKLLGSYQYIGASVDKDLITAKDGMEYYNKMGELYKQHLEAVNAQIKEIEASVpge....qsqlNAQKEELK-.....................-KYLPFLNSIQKEYESLVNMAHTYKENLKKFINNCQIEKKETE.
Q4XT02_PLACH/1-314                 ....---------------------------------.---------------------------------------------KYKLKLERLYQKHEQIEAANQKVKEISVLKSRLLKRKKYINGTFYVLSGFANFFNKRREAEKQYVDNAIKNTDMLLKYYKARSKYFTSEAVPLKTLTKTSIDREANYLKIEKFRAYSRLELRLKKNINLGKERITYVSGGLHHVFEEFKELLKNKGYTGKTNPENAPEVIKAFEQYKELLPK...GATTPAPVVTPAVAPAS-ATTTPADE-------PAAAAAAAAAPASGSAtTTG................................-------------GENGTPVVANSDNDDDDDDDD...MDQIANAQSTDGEVKDILDEFKSENEYIYTKSLGNTYKSFKKHMLKEFSMIKEDIITGLNYKLEKR-----------------------------------------------------------------------------------------...........---------.....................-------------------------------------------.
Q4X6U4_PLACH/1-208                 ...m------------FVDDFEVDNFYKSYLQQVDGN.NTQFIDFIKSKKELINALTPEKVNQLYLDIAHLKELSEHYYNRYYKYKLKLERLYQKHEQIEAANQKVKEISVLKSRLLKRKKYINGTFYVLSGFANFFNKRREAEKQYVDNAIKNTDMLLKYYKARSKYFTSEAVPLKTLTKTSIDREANYLKIEKFRAYSRLELRLKKNINLGKERITYVSGGL-----------------------------------------...-------------------------------------------------.---................................----------------------------------...-----------------------------------------------------------------------------------------------------------------------------------------------------------...........---------.....................-------------------------------------------.
Q8I0U8_PLAF7/981-1536              ....NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYfNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLP-...----EAKVTTVVTPP--QPDVTPSPLSVRVSGSSGSTKEETQIPTSGSL.---................................LTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDE..yLDQVVTGEAISVTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEKFpssppttppspAKTDEQKKE.....................SKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAH.
A5K724_PLAVS/1001-1576             ...v-GGNSEEKPE---ADTAQVEKFYEKHLSQIDKY.NDYFQKFLESQKDEITKMDETKWKALGAEIEELKKKLQVSLDHYGKYKLKLERLLKKKNKISNSKDQIKKLTSLKNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLHHVLTELKEIIKNKKYSGNDHTKNIAAVKEALQAYQELIPK...VTTQEGASTTAATLPVTVPSAVPGGL--PGAGVPGAAAGLTPPPPAGSVpATGpga..........................aagSTEENVAAKAQDYAEDYDKVIALPLFGNNDDDGE...EDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLENHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGASIDMDLATANDGVTYYNKMGELYKTHLDGVKTEIKKVEDDI...........KKQDEELKKlgnvnsqdskknefiakkaelEKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAE.
MSP1_PLAYO/1058-1591               ..gi--RSRAESEEDMPADDFELDNLYKSYLQQIDGN.NTEFINFIKSKKELIKALTPEKVNQLYLEIAHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFNKRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKKNINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKgvtVSTPAVAVTTTLAADAP---ATPEG-AVPGAV-PGAVPGAVPGAVPGAVpGSG................................----------------TDTRVAGSSVDDNEDDD-...IYQIASGQSEDAPEKDILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLSTNKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAET...........NDTNKEEKK.....................-KYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFE.
#=GC seq_cons                      ........ptp..p...hsshph-phYcphLpp.Dt..Ns.hhpFlcSppchIpuhT.pphNtL..EItcLKch.ph.hDhY.KYKLKLERLapK+cpIptspppIKcLolLKs+L.++hp.lNssa.VLpsassFFNK++EAEKp.V-NsLKNT-hLLKYYKARsKYasuEusPLKTLocsSlp+EsNYLplEKFRshSRlEhRLpcNIpLGKE+ISYlSuGLHHlhpEhKEllKNKpYTGps.scNs.tVppAhptYcphLP.........stssTsssss.....ssPts.....u..suushtts..ssusoh.....................................................stllshs.hsps-Dss.....cQlsoGpu.sst.csIlsth.sE.-hlYhKsLushY+SlKKph.pph.shp.shsshLss+LpKRp.FL-VLpp-L..FK..SoscYlIcssapLLs.-pKpp.lhshKYhttulppDlthsp-GlpaapKhhthYK.pLtulpp.Itt.ctph.............pccp.Kc......................KalPhhpslpt.YpsllsthcpY...Lpthlsshp.EKtEhc.
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