GenomeNet

Database: Pfam
Entry: MTD
LinkDB: MTD
Original site: MTD 
#=GF ID   MTD
#=GF AC   PF01993.17
#=GF DE   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase
#=GF AU   Enright A, Ouzounis C, Bateman A
#=GF SE   Enright A
#=GF GA   25.00 25.00;
#=GF TC   25.40 96.90;
#=GF NC   21.70 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7852356
#=GF RT   Cloning, sequencing, and transcriptional analysis of the
#=GF RT   coenzyme F420- dependent
#=GF RT   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene
#=GF RT   from Methanobacterium thermoautotrophicum strain Marburg and
#=GF RT   functional expression in Escherichia coli. 
#=GF RA   Mukhopadhyay B, Purwantini E, Pihl TD, Reeve JN, Daniels L; 
#=GF RL   J Biol Chem 1995;270:2827-2832.
#=GF DR   INTERPRO; IPR002844;
#=GF DR   SCOP; 1qv9; fa;
#=GF CC   This enzyme family is involved in formation of methane from
#=GF CC   carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420
#=GF CC   [1].
#=GF SQ   70
#=GS H1YWR8_9EURY/3-280       AC H1YWR8.1
#=GS A0A151BKS7_9ARCH/5-278   AC A0A151BKS7.1
#=GS A0A120K0H8_9EURY/3-276   AC A0A120K0H8.1
#=GS A0A135VH54_9ARCH/6-288   AC A0A135VH54.1
#=GS MTD_METJA/3-277          AC Q58441.1
#=GS Q46DH9_METBF/2-276       AC Q46DH9.1
#=GS E1RKC0_METP4/3-280       AC E1RKC0.1
#=GS I7LMX2_METBM/3-280       AC I7LMX2.1
#=GS L0KTR5_METHD/2-274       AC L0KTR5.1
#=GS D5EAK3_METMS/2-276       AC D5EAK3.1
#=GS G7WNZ3_METH6/2-272       AC G7WNZ3.1
#=GS D5VSM6_METIM/2-274       AC D5VSM6.1
#=GS A0A151BHW8_9ARCH/5-276   AC A0A151BHW8.1
#=GS A0A0M0BRF6_9ARCH/2-274   AC A0A0M0BRF6.1
#=GS MTD_METMP/3-277          AC Q6M099.1
#=GS A0A0F8VJB7_9ARCH/1-80    AC A0A0F8VJB7.1
#=GS MTD_ARCFU/3-273          AC O29544.3
#=GS MTD_METKA/4-283          AC P94951.3
#=GS MTD_METKA/4-283          DR PDB; 1U6I D; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF G; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1QV9 C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE F; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J G; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ D; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF E; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1QV9 A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J K; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF L; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I F; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ E; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6K B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6K C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF K; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE E; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I K; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1QV9 B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I J; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE D; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF D; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I E; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J F; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J D; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J J; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF J; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I I; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J L; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J I; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I G; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I L; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ F; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQZ C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6I H; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF F; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J H; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF B; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6K A; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF H; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQE C; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 1U6J E; 4-283;
#=GS MTD_METKA/4-283          DR PDB; 3IQF I; 4-283;
#=GS F6D7B4_METPW/3-276       AC F6D7B4.1
#=GS F2KNE0_ARCVS/1-272       AC F2KNE0.1
#=GS MTD_METTH/3-276          AC Q50501.3
#=GS MTD_METHJ/3-280          AC Q2FU89.1
#=GS D2RET8_ARCPA/1-253       AC D2RET8.1
#=GS MTD_METB6/3-279          AC A7I5N7.1
#=GS A0A151BPS8_9ARCH/5-276   AC A0A151BPS8.1
#=GS A0A0Q1A782_9EURY/3-279   AC A0A0Q1A782.1
#=GS D3E118_METRM/3-276       AC D3E118.1
#=GS A0A166ABJ2_9EURY/3-275   AC A0A166ABJ2.1
#=GS MTD_METLZ/3-280          AC A2SPK1.1
#=GS D7DR53_METV3/3-277       AC D7DR53.1
#=GS Q0W2P5_METAR/3-274       AC Q0W2P5.1
#=GS D1YY63_METPS/3-275       AC D1YY63.1
#=GS MTD_METS3/3-275          AC A5UMI1.1
#=GS MTD_METMJ/3-280          AC A3CSZ5.1
#=GS D3RXG7_FERPA/2-272       AC D3RXG7.1
#=GS K4ME31_9EURY/2-277       AC K4ME31.1
#=GS U6EAV6_9EURY/3-276       AC U6EAV6.1
#=GS MTD_METAC/5-279          AC Q8THT2.1
#=GS A0A139CRQ5_9EURY/2-273   AC A0A139CRQ5.1
#=GS A0B7C4_METTP/2-273       AC A0B7C4.1
#=GS E3GZ78_METFV/3-276       AC E3GZ78.1
#=GS F7XNL9_METZD/2-278       AC F7XNL9.1
#=GS N0BIS0_9EURY/2-272       AC N0BIS0.1
#=GS A0A126R1S5_9EURY/3-276   AC A0A126R1S5.1
#=GS A0A166CUS3_9EURY/3-276   AC A0A166CUS3.1
#=GS A0A0M0BF28_9ARCH/5-278   AC A0A0M0BF28.1
#=GS D7EB48_METEZ/2-277       AC D7EB48.1
#=GS A0A151BE88_9ARCH/3-276   AC A0A151BE88.1
#=GS MTD_METPE/3-280          AC B8GJQ7.1
#=GS A0A101DXC9_9EURY/2-276   AC A0A101DXC9.1
#=GS MTD_META3/3-277          AC A6UWS1.1
#=GS A0A147JSR5_9EURY/5-277   AC A0A147JSR5.1
#=GS R9SJF9_9EURY/3-276       AC R9SJF9.1
#=GS F4BZ98_METCG/2-272       AC F4BZ98.1
#=GS F0T7A4_METLA/3-276       AC F0T7A4.1
#=GS L0HKS1_METFS/3-279       AC L0HKS1.1
#=GS MTD_METST/3-276          AC Q2NHQ2.1
#=GS J0RY20_9EURY/3-280       AC J0RY20.1
#=GS A0A0F7DBG0_9EURY/2-272   AC A0A0F7DBG0.1
#=GS A0A124G5N9_9EURY/24-301  AC A0A124G5N9.1
#=GS A0A0E3NUC0_9EURY/2-276   AC A0A0E3NUC0.1
#=GS A0A135VUY1_9ARCH/6-287   AC A0A135VUY1.1
#=GS A0A0P7ZDL2_9EURY/3-275   AC A0A0P7ZDL2.1
#=GS A0A166CS26_9EURY/3-276   AC A0A166CS26.1
#=GS A0A101DQ41_9EURY/3-276   AC A0A101DQ41.1
#=GS A0A0M0BS79_9ARCH/2-275   AC A0A0M0BS79.1
#=GS A0A166CNE9_9EURY/12-285  AC A0A166CNE9.1
#=GS MTD_METMA/5-279          AC Q8PXV8.1
#=GS A0A101J2P9_9EURY/3-280   AC A0A101J2P9.1
#=GS Q12XF4_METBU/2-273       AC Q12XF4.1
H1YWR8_9EURY/3-280                  .VKVGIAKLGNIGSGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVDN.M...K..AWGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDITSK.....K...DdfAALKE....S.....NFGYIIMKADSMIGARREFLDPVEMSDYNGNLIKVLTITGAFRKLQLALDAVIDQVKAGKkgaELELPKIVMTSDKAVA-DEFTNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGHENYTPIVASAHEMMRSATLLCDEAREIEKGCDGVIRMPHKND.G.EIVKKTALISKP-w..
A0A151BKS7_9ARCH/5-278              .VKIGVLKAGCIGTLPLLEVMLDERADRADIDVRVIGSGAKLGPEQCREVAEQ.M...I..RLKPDLVILIGPAQAAPGPSEARRILSEAGLP..TIVISDLPAKK.....L...T..GEIEK....A.....GMGYIIVEADSMIGARREFLDPTEMVLFNSDVIRVLAATGAFNLVVEAIDRAIEALKRGE...APELPRLVIDGAKAVEAAGFLNPYAGAKALAAYEMARQVSRITTAACFKTQDPKVYIPMVAAAHELMREAAKLADEAREIEKGQDQVLRRPHFKD.G.SAGTKRRLMEKP-a..
A0A120K0H8_9EURY/3-276              .VKIAIIKSGNIGTSPVIDLLLDERADRPNIDVRTFGSGAKMNPEQVEDVVPK.I...D..AFEPDFAIFISPNPGAPGPARARELLSEKDVP..AIIIGDAPGKG.....K...K..DEMDE....Q.....GLGYIIVMSDPMIGAKREWLDPTEMAIFNSDILKVLAETGALRLVQKTIDGVIAQADAGE...EIELPKLIVTAEKAAEAGGFANAYAKAKAIAAYEMAGSVANLDMKGCFMTKGFENFIPLVAAAHEIAACAAKLAQEAREIEKANDTVLRTPHMKE.G.NPGCKTELISKP-q..
A0A135VH54_9ARCH/6-288              i-NVGVIKLGAIASAPLLDLIFDERAERDDINVRAFTSGAKMDEESSIGPAES.L...I..AWAPHLVLIVSPNAALPGPTKVREMLAEAKLP..TISISDGPAEK.....AfykK.dDEGKK....QpyvldGQGFIVIPADSMIGAKKEFLDPTEMSLFNADAIKVLSITGVVRAIQHELDIVIAAIQAGE...TPKMPLVKLTAEEIVKCGYFKNPYAKAKAIAALTISEAVAEVTTKGCFKTKEAEDYIPLVAAGHEMMRAAAKLADEIRELEKAGDSVLRNPHVSK.G.KVKTKTALMDKP-k..
MTD_METJA/3-277                     .VKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVEEVTKKmV...E..EVKPDFIIYIGPNPAAPGPKKAREILSQSGIP..AVIIGDAPGLR.....V...K..DEMEQ....Q.....GLGYIIIKCDPMIGARREFLDPVEMALFNADVIRVLAGTGALRIVQEAIDKMIDAVKEGK...EIELPKIVITEQKAVEAMEFTNPYAKAKAMAAFTIAEKVGDVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKAMDAVSRKPHHPE.G.KRLSKKALMEKPE...
Q46DH9_METBF/2-276                  .VNIGFIKMGNLGMSQVINLVQDEIAAREGITVRVFGTGAKMSPAEAA-ASES.F...K..QWNADFVIIISPNAAAPGPKAAREIW--KDVP..CIVVSDGPTKK.....E...A.rEALEN....N.....GFGYLILPVDPLIGAKREFLDPVEMASFNSDAMKVLSVCGVVRLVQEELDKVTDQVASGKsgkELELPHIFAKPEKCVEYAGFANPYAKAKALAALHMAEKVAQVNFPACFMLKEIDQVCLTAAAGHEIMGAASQLAIQAREIEKSNDTVLRQPHAKN.G.TLLKKVKLYQKPE...
E1RKC0_METP4/3-280                  .VKVGIAKLGNIASGVMAELLLDERADREDMETFMATSGTKLQEKDIDRVVEN.M...K..AYGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDITTK.....K...DefAALKE....T.....SFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAVTGAFRKLQIALDEVIDQVKEGKkgaDLVLPKIVMSSDKAVE-GEFTNPYAYAKARAAYEMAQSVAGINVKGCFMTKGHENYTPIVASAHEVMRQAMLLCEEAREIEKSCDGVIRKPHKSD.G.TRVEKVKLIDKP-w..
I7LMX2_METBM/3-280                  .VKVGIAKLGNIASGVMAELLLDERADREDMITFMATSGTKLQPEDIDRVVSN.M...K..AWAPDFCIVVSPNGVLPGPTQAREDLAAAGIP..CIVITDDVTTK.....K...DqfAALKE....S.....DFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAITGAYRKMQLELDKVIDQVKAGKkgkDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQQVAAVNVKGCFMTKEWEKYIPIVASAHEMMRQAMILCEEARDLEKGMDAVIRKPHKKT.G.EIVSKTKLISKPE...
L0KTR5_METHD/2-274                  a-KIGIIKLGNLGMSQVVDLVQDEIAAREGITVRVFGTGPKMGKDEAA-ATAD.L...K..KMEADFYVMISPNSSAPGPTAARELY--KDVP..CIIISDGPTKK.....E...D.rEALQQ....A.....GFGYIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKVAALVDAGE...PIQLPHILAKPEVCIERAHFNNPYAKAKGLAALHMADMVAKINFPACFMMKELEQVALTTAAGHEMMRAAAQLAIEAREIEKANDSVFRQPHSKKgG.KQFQKTKLYEKP-q..
D5EAK3_METMS/2-276                  .VKVGFIKLGNLGMSQVIDLVQDEIAAREGITTRVFGTGPKMDKETAA-STEE.L...K..AWDPDFVVMISPNASAPGPKSARELW--KDYP..CIVVSDGPTKK.....D...D.rQALED....A.....GFGYIIMTVDPLIGAKTEFLDAVEMASFNSDAMKVLSTCGVVRLLQEELDAVTAQVDEGKsgaDLELPHILAKPQKCIERAGFNNPYAKAKGLAALHMASKVAEVNMPACFILKEIEDVTLTAATGHELMRAASQLAIEAREIEKANDSVFRQPHSKK.G.FQLQKTKLYEKP-q..
G7WNZ3_METH6/2-272                  .FKIGFIKLGNVASSLVADLALDEIAERTDVEVRSLSFGAKMTVKEAE-MSAE.L...K..GWGPQLVVIVGPNAATPGPTAARALY--RDVP..TIVISDGPSKK.....E...A.rEALEA....E.....GFGYIILPFDPLIGAKREFLDPAEMALFNSDALKVLSICGSVRLVQEELDGAMASIISGA...-PRLPTILSSPEGCTDRMAFRNPYARAKAIGALHMAQTVAGIDAAACFRLKELDRIALTAAAGHEVMRAAARLADEARELEKSTDSVSRRPHARS.G.AILAKTGLLDKPE...
D5VSM6_METIM/2-274                  .VKVGIVKCGNIGTSLVVDLALDERAER-DINVLVYGSGAKMNPESVEYVVKK.M...I..EEKPDLIIYIGPNPAAPGPRKARELLSECKIP..SIIIGDAPGIK.....V...K..DEMEK....E.....GLGYILIKGDPMIGARREFLDPTEVALFNSDILKVLAVTGVVRLVQEEIDRVIEYIKEGK...EPELPRIVVDAEKAVERMEYSNPYAKAKAIASYNMAEEVANIDVKACFMVKEPERYIILAASAHELLRQAAKLADEARELEKATDMVSRKPHAKD.G.RILSKRKLLEKP-q..
A0A151BHW8_9ARCH/5-276              .VKVGIVKVGCIGVLPLIEVLLDERADRSDIDVRVVGSGAKLGLEQCREVTDL.M...V..RQKPDLVILIGPAQAAPGPTEARRLLAEAGIP..TIMISDSPAKK.....L...A..KNMEK....E.....GLGYIIVEADSMIGARREFLDPTEMALYNSDVIRVLAATGALSLIVREIDKVIDSLKRGE...EPVLPRLTIDKG--LIASNFKNPYAGAKAVAAYEIARNVAKLNTEACFKVQEWTVYTQLAASGHEMMRTAAELADEARELEKSNDSVLREPHFKD.G.TLGEKRALIEKP-k..
A0A0M0BRF6_9ARCH/2-274              .VRIGFVKVGNIATSPMVELLLDERAEREDMEVRVLTSGANMGAKQSEDVAKS.M...I..ALKPDVAFVASPNASTKGPTRAREVLAEAGIP..VVVITDGPGK-.....L...L..EELGA....K.....GLGGIIVEADSMIGARREFLDPIEMAIFNADTTKVLSVTGVYNVVYAAIDAVIEQLKAGK...KPELPLISVTSEMAIEAAGFSNPYARAKAAAAYEMARRVASLTTRACFREKDWEVYTALCAAAHELMRSAAVLADEAREIEKYGDSVLRRPHFDD.G.STLEKRRLIEKP-r..
MTD_METMP/3-277                     .VKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMGPEQVEEVAKKmV...E..EIKPDFIVYIGPNPAAPGPKKAREILSAGGIP..AVIIGDAPGIK.....D...K..DAMAE....E.....GLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKLVDEARELEKATDAVSRKPHAGA.G.KILNKCKLMEKPE...
A0A0F8VJB7_9ARCH/1-80               .----------------------------------------------------.-...-..--------------------------------..-----------.....-...-..-----....-.....------------------------------------------------------------...-----------------------------IAAFELATSVSKLTGKACFQLKEKSDYMPLLAAAHEMMRTAAIMCDEAREIEKYNDTVIRKPHNSK.Q.QLLTKKGLYDK--et.
MTD_ARCFU/3-273                     .VKVGVLKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAV-VAEK.L...K..EFDPDVVIVVSPNAALPGPKAAREAF--EGKP..VIVISDAPAKK.....A...K..DELKE....K.....GFGYILINADSMIGARREFLDPTEMALFNADVVKVLAATGAFRLVQEAIDKVIEDIKAGK...QPELPQIVVTAEKAVEAGKFSNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAILADQAREIEKSNDTVFRNPHAKD.G.KILGKTQLMAKPE...
MTD_METKA/4-283                     a-KAIFIKCGNLGTSMMMDMLLDERADREDVEFRVVGTSVKMDPECVEAAVEMaLdiaE..DFEPDFIVYGGPNPAAPGPSKAREMLADSEYP..AVIIGDAPGLK.....V...K..DEMEE....Q.....GLGYILVKPDAMLGARREFLDPVEMAIYNADLMKVLAATGVFRVVQEAFDELIEKAKEDEi.sENDLPKLVIDRNTLLEREEFENPYAMVKAMAALEIAENVADVSVEGCFVEQDKERYVPIVASAHEMMRKAAELADEARELEKSNDAVLRTPHAPD.G.KVLSKRKFMEDPE...
#=GR MTD_METKA/4-283          SS    E-EEEEEEES--HHHHHTTGGGSTTS--SSEEEEEEEEET--SHHHHHHHHHHHHHHHH..HH--SEEEEE-S-TTSHHHHHHHHHHHHSSS-..EEEEEEGGGGG.....G...H..HHHHH....T.....T-EEEEETTS------TTT--HHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTT--.-GGGS-EEEESGGGGGGSS--SSHHHHHHHHHHHHHHHHHHHHHHHHHHT---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT---B--B-TT.S.SB--BSSTTS---...
F6D7B4_METPW/3-276                  .VKIGVIKCGNLGTSPVIDLMLDERADRPNISVKSFGSGAKMGPEEIEEVVPK.V...A..DLDAAFVIFISPNPAAPGPAKARELLSAMDVP..AIIVGDGPGAR.....V...K..DEMNE....Q.....GLGYILVKGDPMIGARREFLDPTEMASFNADVIKVLAATGAYRCVQKTLDALIAAAEAGE...AIEVPKLVLTRDKAIAAAEFKNPYAKAKAMAAYTIAEKVADIDVEGCFMTKDAEKYIPIVASSHEMIAVAAKLAAEAREIEKANDTVLRTPHSGK.G.QLVSKTTLMSKPE...
F2KNE0_ARCVS/1-272                  m-RIGIIKLGAIATALLIDYMLDERADREDIDVRTITSGSKLRERDAE-IVDK.M...R..EFNPDLVIVASPNAALPAAKLARDALKAEGKP..VIVISDAPAKK.....V...K..DELEA....E.....GFGYILVNADSMIGARREFLDPTEMCLYNSDVIKVLAATGAFRAVQLAVDEAIESAKAGK...-PKLPRLIIDAEAAVNAGNFSNPYARAKAMAAYTIAEKVAAVTTKACFVEKDAEKYIPMVAAAHEMMRYAAKLAEEAREIEKSSDAVYRTPHAKD.G.RVLSKWGLMEKP-s..
MTD_METTH/3-276                     .VKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPT.M...L..EMDRDFVIFISPNPGAPGPAKARELLSEADVP..AMIIGDAPGLR.....V...K..DEIEE....Q.....GLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGK...APELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKLAVEAREIEKANDTVLRTPHGKE.G.ETLSKTDLLAKPE...
MTD_METHJ/3-280                     .VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVTN.M...K..AWGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDITTK.....K...EewEALKA....S.....EFGYVIMKGDSMIGARREFLDPIEMADYNGNLIKVLSITGAFRKLQVALDEVIDQVKAGKkgkDLALPKLVMTSDKAVE-GEFSNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGFENYTPIVASAHEMMRQAMLLCEEAREMEKATDAVIRKPHKND.G.TRVAKKTLISKPE...
D2RET8_ARCPA/1-253                  m-RIGIAKLGAIGSAVLLEYCLDELAMRGDIETFVVSSGSKIKVEVLEE----.L...E..KRDFDLKIVTCPN--------AEKFLKDVNLSdrVIVITDRASK-.....-...-..DWLDS....L.....NWGYIVVKADAMIGARREFLDPTEMVLYNSDLLKVLAVTGIIRLLQYEINRALK------...EDYLPKVVVDYNTAVKFAGFCNPYARAKAIASYIIAENISKITHKACFVEKDAENYITLCATAHEMMRIAGKLADEAREIEKSNDSVLRTPHSKS.G.EILKKVGLYD---v..
MTD_METB6/3-279                     .VKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVSN.M...K..AWKPDFAIVVSPNGVLPGPTGAREQLAAAGIP..VIIITDDVTTK.....K...E.wEEVKN....S.....KFGYIIMKADSMIGARREFLDPIEMADFNGNLVKVLAITGAFRKLQLALDKVIDQVKAGKkgtEIELPKIVMTTDKAVD-GEFTNDYALAKARAAHEIAIAVAGQNVKGCFMTKEWEKYIPIVASAHEMMRIAAVLCDEAREIEKAGDGILRQPHKKD.G.VLVRKTKLVAK--fe.
A0A151BPS8_9ARCH/5-276              .VKVGIVKAGCIGVLPLIEILLDERADRTDIDVRVVGSGAKLGLEQCQEVTDI.M...I..KQKPDLAILVGPAQAAPGPTEARRMLAEAGIP..TVVISDSPAKK.....L...T..KEMED....A.....GLGYIIVEADSMIGARREFLDPTEMALYNSDVIRVLAATGVLSLIVREIDRVIDSLKKGE...EPVLPRLIIDKGL--VASNFKNPYAGAKAVAAYEIARNVARLNTEACFKVKEWTVYTQLAASGHEMMRAAAQLADEARELEKSGDSVLREPHFRD.G.TLGEKRSLIEKP-k..
A0A0Q1A782_9EURY/3-279              .IKVGVAKLGNIASGVMVELLLDERADRTDMQTFMATSGTKLEVEDVDRVVSN.L...K..AYGPDFAIVVSPNGVLPGPAGAREALKAAGIP..VIVITDDVTTK.....K...E.wPELKE....S.....GFGYIIQKADAMIGARREFLDPIEMADYNGNLVKVLSITGAFRKMQLAIDEVIDQVKAGKkgaELVLPKLVVTADKAVA-GEFTNPYAYAKARAAFEIAAAVAMVNVKGCFMTKGFENYVPIVASAHEMMRVAALLCDEARELEKGVDGVVRKPHKND.G.TIVSKTALISKPE...
D3E118_METRM/3-276                  .VKIGIVKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPK.L...D..QFDPDFCIFISPNPGAPGPARARELLSEKDLP..AIIIGDAPGKG.....K...K..DEMDE....Q.....GLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQKTLDAVIAAADAGE...EIELPKLIVTAEKAVEAAGFANPYAKAKAIAAYEMAGAVAGLDMKGCFMTKGFENFIPLVAAAHEIASAAAKLAQEAREIEKSNDTVLRTPHMKE.G.NLGCKVDLISKP-v..
A0A166ABJ2_9EURY/3-275              .VKIGIIKSGNIGTSPVIDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPK.L...D..QFNPDFAIFISPNPGAPGPAKAREILSEKGIP..AIIIGDAPGKS.....K...T..DEMDE....Q.....GLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLANTGALRLVQKTIDAVIEGAEADN...-IELPKLIITAEKAVAAAEFTNPYAKAKAIAAYEMAGAVANLDMKGCFMTKGYENFIPLVAAAHEMASAAASLAHEAREIEKANDTVLRTPHMKE.G.NLGYKNCLISKPE...
MTD_METLZ/3-280                     .VKVGVAKLGNIAAGVMAELLLDERADREDMMTFMATSGTKLQKEDVDRVVSN.L...K..AWQPDFAIVVSPNGVLEGPVGAREDLKAAGIP..TIVITDDVTTK.....K...EgwEALKA....S.....GFGYIIVKADAMIGARREFLDPVEMADYNGNLVKVLALTGAFRKLQLELDKVIDQVKAGKkgaELELPKLVLNSDNSTK-GEFTNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWTDYVPIVASAHEMMRAAANLCDQARELEKGCDGVIRKPHKKT.G.EIVSKVALISKPE...
D7DR53_METV3/3-277                  .VKVGIIKCGNIGMSPLVDLSLDERADRNDIDVRVVGSGAKMGPEQVEEVTKKmI...E..DIKPDFVLYIGPNPAAPGPKVARELLSAADIP..AVIIGDAPGIK.....D...K..DAMAE....Q.....GLGYILIKCDPMIGARRQFLDPVEMSMFNADVVRVLAGTGAVRVVQNAIDAMIYAVEEGK...EIELPKIIVTDAKAVAAAEFSNPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMDKYIPIVASAHEMIRYAAKLVDEARELEKATDGVSRKPHAGP.G.AILNKSKLMEKPE...
Q0W2P5_METAR/3-274                  .VRVGIVKLGNIGTSRFIDLVLDERADR-DIYVRTVGAGAKMGEAEAE-EMKK.I...I..DFKPQFCIVISPNATVPGPTKAREMLKEAGIP..TIVISDSPVLK.....I...K..DDLKA....K.....GFGYFVVKCDPMIGARRQFLDPTEMVLFNADVLKVLANTGVVRLIQKELDAVIEGFAAGQ...TPALPQIVISADKAVAAAGYKNPYAKAKAMAAFVAAEKVADIDLQGCFMQKEMEQYIPTVASAHELLREAAKLSDEARELEKATDAILRTPHAAD.G.KVLSKTQLMLKPE...
D1YY63_METPS/3-275                  a-RVGIVKLGNLGTSRYIDLILDERADR-DIYVRTVGTGAKLGEAEADEAVAK.I...L..EFKPQLCIVISPNGALPGPTKAREAIKAAGVP..TIAISDVPMMK.....V...K..DDLKA....K.....GLGYFIVKCDSMIGARRQFLDPTEMVLFNADMTKVLAETGVVRLIQTELDKCIDMINAGQ...PVTVPQIVIDAAKAVPMAGYTNPYAQAKAFAAFAAAEKVGDLDLLGCFMQKEMEQYIITVASAHELLRTAALLCDQARELEKGGNSIKRTPHAAD.G.KVLSKTTLVSKPE...
MTD_METS3/3-275                     .VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPK.V...D..QFDPDFCIFISPNPGAPGPAKARELLSEKDIP..AIIIGDAPGKG.....K...K..DEMDE....Q.....GLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQNTIDGVIDGAAAGN...-IELPKLIITAEKAVEAAGFENPYAKAKAIAAYEMAGAVANLDMKGCFMTKGFENFIPLVAAAHEMAASAAALADEAREIEKGNDSVLRTPHMKE.G.NTGCKTDLISKPE...
MTD_METMJ/3-280                     .VKVGIAKLGNIASGVMGELLLDERADREDMITFMATSGTKLQPEDIERVVSN.M...K..AWGPDFCIVVSPNGVLPGPTQAREDLAAAGIP..CIVITDDVTTK.....K...EqfEALKA....S.....NFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLALTGAFRKMQMELDKVIDQVKAGKkgaDLALPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQSVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAMLLCEEARTLEKGVDAVIRKPHKKT.G.EIVSKTALISKPE...
D3RXG7_FERPA/2-272                  .VKVGILKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAK-IAEK.L...K..EFDPDLVLVVSPNAALPGPKAAREAF--EGKP..VIVISDAPAKK.....A...K..EEFEQ....K.....GFGYILVNADSMIGARREFLDPTEMALFNADVVKVLAATGAFRIVQEEIDKVIEALKKGE...KPELPKVVITAERAVEAAKFSNPYAKAKAMAAYFIAEKVADVDVRGCFIEKDPEKYIPLVAAAHEMMRIAAKLADEAREIEKSNDTVFRNPHARD.G.KILSKTKLMEKP-q..
K4ME31_9EURY/2-277                  a-KIGFIKLGNLGMSQVIDLVQDEIAAREGISVRVFGTGPKMGKDEAA-ATAE.L...K..NWGADFYVMISPNASAPGPTAAREIY--KDVP..CIIISDGPTKK.....E...D.rEALEA....A.....GFGFIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKVTTMVDEGKsgkELELPHIVAKPEKCIERAGFSNPYAKAKGLAALHMADMVAKINFPACFMMKEIEQVTLTTAAGHEMMRAAAQLAIEAREIEKANDSVFRQPHAKK.GgRLMTKTKLYEKP-q..
U6EAV6_9EURY/3-276                  .VKIGVIKSGNIGTSPVLDLVLDERADRPNIDVRGVGSGAKMNPEQVEEVVPK.I...M..DFDPDFVIFISPNPGAPGPAKARELLSEMDIP..ALIIGDAPGMG.....K...R..EEMDE....Q.....GLGYIVVLGDPMIGARREFLDPTEMASFNADVIKVLAATGAYRVVQETIDEMIAACEAGK...DIELPKVVIDAATATEAAGFANPYAKAKAMAAYEMAAKVGDIDLKGCFMVKDMEKYIPIVASAHELIAAAAQLATEAREIEKANDTVLRKPHGSK.G.QTMSKTVLVSKPE...
MTD_METAC/5-279                     .VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMGPADAA-DTES.F...K..QWNADFVVMISPNAAAPGPTAAREIW--KDVP..CIVVSDGPTKK.....E...A.rEALEQ....E.....GFGYIILPVDPLIGAKREFLDPVEMASFNSDAMKVLSSCGVVRLIQEELDRVTEQVASGKsgeDLELPHIFAKPEKCVEHAGFANPYAKAKALAALHMAEKVAQVNFPACFMLKEVEQVCLTAAAGHEIMGAAAILATQAREIEKSNDTVFRQPHAKN.G.TLLKKVKLYEKPE...
A0A139CRQ5_9EURY/2-273              a-KIGFIKLGNLGMSQVIDLVQDEIAAREGITVRVFGTGPKMGKDEAA-ATEE.L...K..KFDADFYVMISPNSSAPGPTAARELY--KDVP..CIVISDGPTKK.....D...D.rAALEE....A.....GFGYIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKVAAMADEGK...ELELPHILAKPEKCIERAGFNNPYAKAKGLAALHMADMVAKINFPACFMMKEIEQVALTTAAGHEMMRAAAQMAIEAREIEKANDSVFRQPHSKK.G.KLLTKTTLYEKP-q..
A0B7C4_METTP/2-273                  .FKIGFIKLGNIASSLVVDLALDEIAERTEIESKVVSHGPKMSRGEGERLAEE.M...R..AWGPQMVVVVSPNAATPGPTAARSML--KGIP..LIVISDGPTKK.....E...A.rDAMET....E.....GFGYIILPMDPLIGAKREFLDPAEMAIFNADALKVLSICGAVRLVQEEIDRAIASVAAGS...-PQLPHILATPELCAERMDFANPYARAKAIAALYMAQTAASIDAQACFRLKELEAIALAAAAGHEVIRAAARLADEARELEKSGDTVSRKPHARS.G.DLLVKRKLLEKP-a..
E3GZ78_METFV/3-276                  .VKIGVIKCGNIGTSPVIDLLLDERADRPNIDVRVIGSSAKMNPEQVEDVVPK.M...L..DMDRDLVIFISPNPGAPGPAKARELLSESDVP..SIIIGDAPGKR.....V...K..DEIEK....Q.....GLGYIIVEADPMIGARREFLDPTEMASFNADVIKVLACTGAYRLIHKTLDDLISDLEAGK...EIELPKLIIDSEKAVEAGEFENPYAKAKAMAAYEIAAKAADLDVKGCFMVQDPEKYIPIVASAHEMVSIAAKLASEAREIEKSNDTVKRTPHGKK.G.ELLEKVELMAKP-k..
F7XNL9_METZD/2-278                  a-KIGFIKLGNLGISQVIELVQDEIAAREGISIRVFGTGPKMGKDEAA-STEQ.F...KdmSWDADFYVIISPNASAPGPTAAREIW--KDVP..CIIVSDGPTKK.....D...D.rQALEE....A.....GFGYIILKVDPLIGAKTEFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDKVVEQVDAGKsgsDIELPHILAKPEVCVERAGFENPYAKAKALASLFMAEKVAQINFPACFMMKELEDVALTTATGHEMMRAAAELAVQAREIEKINDTVSRHPHSKK.G.KVLSKTRLFEKP-a..
N0BIS0_9EURY/2-272                  .VKVGVVKMGAIGTALLVEYLLDERADREDITVRVVTSGAKMQPEEAE-IVEK.M...K..EFDPDLVIVVSPNAALPGPKAAREAF--EGKP..VIVISDAPAKK.....A...K..EEFEE....K.....GFGYILVNADSMIGARREFLDPTEMALFNSDVVKVLAATGAFRLVQEEIDKVIEALKEGK...TPELPKIVVTAEKAVKAGNFKNPYAKAKAMAAYYIAEKVADIDVKGCFIERDPEKYIPLVAAAHEMMRVAAIEADRAREIEKGGDSVYRNPHAKD.G.KILSKTSLMEKP-q..
A0A126R1S5_9EURY/3-276              .VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPK.V...D..QFDPDFCIFISPNPGAPGPDKARELLSEKDCP..AIIIGDAPGKG.....K...K..DEMDE....Q.....GLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLIQKTIDGIIEAADEGK...EIELPKLIITAEKAVDAAEFQNPYAKAKAIAAYEMAGAVANLDMKGCFMTKGYENFIPLVAAAHEMAAYAAKLAQEAREIEKSNDTVLRTPHMKE.G.NIGCKFDLISKPE...
A0A166CUS3_9EURY/3-276              .VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVVPK.V...K..EFNPDFAIFISPNPGAPGPAKARELLSGYDIP..AVIIGDAPGAS.....K...K..DEMNE....Q.....GLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLSLTGAYRLVQTAIDGLIADVEAGK...DLELPKIILTAEKAAEAAGFANPYAKAKAIAAYEAASTVANIDTKGCFMVRDAEQYIPLVAAAHELIGVAAKLATEARDIEKSNDTVLRTPHNKD.G.AIVTKTALLDKP-a..
A0A0M0BF28_9ARCH/5-278              .VRVGVLKAGCMGSLPLVEFLVDERADRSDVDVLVSGSGAKLGLKQCETITAW.I...I..AQKPDFTVLIGPAQQAPGPTKARKLLVEAGVP..TVVISDGPARK.....I...V..SRLEA....D.....GFGYIIIDADAMIGARREFLDPVEMALFNADMIKILAVTGVLRVITESLDDLIQAVKSGS...GLQLPRLLVTKESAVASSGLINSYARAKAMAAYEIARHVAGVDSTACFKVPEWTRYVPLVTSGHEMIRAAAKLADDAREMDKVGDALVRRPHFPD.G.VLGFKTKLMEKP-q..
D7EB48_METEZ/2-277                  .VKVGFIKLGNLGMSQVVDLLEDEIAAREGITTRVYGTGPKMSKEDAADTEAF.K...E..EFDPDFVIIISPNASTPGPTEARQLW--KDKP..CLIISDGPTKK.....D...D.rQAIED....E.....GFGYIILPVDPLIGAKTEFLDPEEMASFNSDVMKVLSTCGAVRLVQEELDKLTSQVDEGKsgdEIEMPHIYAKPQTCIERSGFSNPYAKAKALAALHMAEKVSQINLPACFMLKDLEEVAFTAATGHEMIRAAAELAVEAREIEKTNDTVLRKPHSKK.G.KVLSKTKLYEKP-q..
A0A151BE88_9ARCH/3-276              .VKVGFAKVGNIATAPLIEFLLDERADRNDIDVRVVSSGAKMGVEQAEEVAKK.L...L..EFKPDFAVVTSPNATLPGPKRLRELLAEGGIP..VIVVSDAPAKK.....I...V..KKLQE....A.....GFGYIIVTADAMIGARREFLDPVEMALFNADLIKVLAVTGVFNIVQVELDKVIDAFKNGE...KPTLPRIVIDKDKAVEAANFSNPYAKAKAMASFEIARRVADLTVEGCFMVKEWERYTLLVAAAHEMMKTAAKLADEARELEKATDSVYRSPHSRA.G.LILSKRKLIEKP-a..
MTD_METPE/3-280                     .VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVST.M...K..AWEPDFCIVVSPNGVLPGPVGARDELLKAGIP..CVVITDDITTK.....K...EgwEALKA....S.....SFGYIIMKADAMIGARREFLDPVEMADFNGNLVKVLALTGAFRKLQTELDKVIDQVKEGKkgaDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAAALGDEAREIEKAGNGIIRKPHKKD.G.TIVSKITLISKPE...
A0A101DXC9_9EURY/2-276              a-KVGFVKLGNLGTSQGIDLLLDEIAQREGIEVRVLGSGAKMTPKEAE-ESAE.L...K..QWGPDFVIIISPNAMAPGPTKAREIW--SDTP..TIVISDGPTKK.....D...D.rKAIEE....A.....GFGYIIIPMDPLIGAKRQFLDATEMISFNSDVLKVLSLTGVSRLVKEELDKVIAQVDAGKsgkELELPHILVTPEKCTERMNFSNPYARAKAMAAAHIASKVPDLTFKACFVYKDIEDIVLAAAAGHEMMRIAAKLAEESREIEKTLDEVSRMPHAKS.G.ETLSKMKLYEKP-q..
MTD_META3/3-277                     .VKIGIIKCGNIGMSPLIDLALDERADRTNIDVISIGSGAKMGPNQVVEVTTKmV...E..DIKPDFIIYVGPNPAAPGPAKAREILSASDIP..SVIIGDAPGIK.....A...K..DKMAE....E.....GLGYILIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGAARVVQNAIDDIVEAIEAGN...EIELPKIVVTDAKSVAAAEFSNPYAKAKAMAAFAMAEQVANIDVKGCFMTKEMEKYIPIVASAHEMIRTAAKLVDEARELEKATDSVSRKPHGAD.G.KRLNKTKLMEKPE...
A0A147JSR5_9EURY/5-277              .VRVGLVKMGNLGTSAMLDLMLDERAEREGIDFRVVASGPKITEEDCEGVSKK.I...L..DFNPELIIAISPNPALPGPSKAREILKKSGKP..CIIIGDAPGAK.....I...A..GELEK....T.....GFGYIFVEADSMLGARMEFLDPVEMSLFNADVIKVLSVTGASRVVYEETDKAIEGVKSGK...-PYLPRIIVDRDKAVGAAKFENPYARAKAMAAFEIAKKVADVSVEGCFRVKEKERYIPIVAAAHEMMRTAAKLCDEAREIEKSEDSVLRRPHGRK.G.ELLSKRKLMEN--en.
R9SJF9_9EURY/3-276                  .VKIGIVKSGNIGASPVLELLLDERADRPNIDVRVFTSGAKMNPEQVEDVVPK.V...K..DFNPDFVMFSSPNPTAPGPAKARELLSEMDVP..AFIIGDAPGKR.....A...K..DEMDE....Q.....GIGYIIVEADSMIGARREWLDPTEMSVFNSDLIKVLACTGAYRLIQNTIDGVIAQADAGE...EIELPKLVINAQKAVDAAGFTSPYAKAKAYAAYEMCAKVADLDMKGCFMMKNYEEFLPVVAAAHEMASAAAQLATEAREIEKANDTVLRTPHMSD.G.STGKKVNLISKPE...
F4BZ98_METCG/2-272                  .FKIGFVKLGNIATSTAIDLSLDEIAERTDIEFKIISFGPKMTEKEGK-GAEE.L...K..AWQPQLVVISSPNAATAGPTAAREAY--RGIP..TIIISDGPSKK.....E...A.rEALSA....E.....GYGYIILPMDPLIGAKREFLDPAEMALFNSDALRVLAACGAIRLVEEELDRTIASIISGQ...-AKLPTILATPEKCAERMHFSNPYAQAKAMGALYMAQTVASIDAAACFRLKELKPIALTAAAGHEVMRAAARLADEARELEKSNDTVSRQPHART.G.ELMQKLSLLDKPE...
F0T7A4_METLA/3-276                  .VKIGIIKCGNIGTSPVIDLLLDERADRPNIDTCVVGSGAKMNPEEIEKAVPL.M...L..EMDRDFVIFISPNPGAPGPAKARELLSAADVP..AIIIGDAPGLR.....S...K..DEMDE....Q.....GLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLALTGAYRVVQNTIDAAVTAVESGE...TLELPKVVITRDKAVEAAAFGSPYAKAKAMAAYEIATKVADIDVEGCFMVRDAEKYIPLVASAHEMLGVAAKLASEARDIEKANDTVVRTPHGGK.G.QTLSKVALADKPE...
L0HKS1_METFS/3-279                  .VKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVSN.M...K..AWKPDFCIVVSPNGVLPGPTGAREELAKSGIP..CIVITDDVTTK.....K...E.wEGIKT....S.....SFGYIIMKADSMIGARREFLDPIEMADFNGNLVKVLAGTGAFRKLQVAIDQVIDQVKAGKkgaELVLPKIVMTTDKAVD-GEFTNNYALAKARAAHEIAMAVAGQNVKGCFMTKEWEKYIPIVASAHEMMKVAAALCDEAREIEKAGDTVLRQAHKKD.G.VLVRKNKLVAK--fd.
MTD_METST/3-276                     .VKIGIVKVGNIGTSVLIDMILDERADREDIDVRTISSGAKMGKNQMDDVLPK.I...D..EYNPDVIIFISPDPGAKSPSSARETLSKKNIP..TIVIGDGPGER.....A...I..GSMKE....Q.....GLGYIIVKADSMIGARREFLDATEMAVFNSDVLMVLSTTGVFRLIHKTLDKVIRDIDEDK...LYSLPELVITAENAVDAADFKNPYAKSKAIAAYSIACQVSSMNVRACFKTKDYHVYIPLVSAAHEMMSAASKLAYEAREIEKSNDTVVRTAHRRN.G.SILYGTSLND---nke
J0RY20_9EURY/3-280                  .VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVTN.M...K..AWGPDFCVVVSPNGVLPGPTGAREELAKAGIP..VVVITDDITTK.....K...EqfDALKA....S.....TFGYIIMKADSMIGARREFLDPIEMADYNGNLVKVLALTGAFRKLQFELDKVIDQVKAGKkgaDLVLPKVVMTSDKAVE-GEFSNPYALAKARAAYEIASAVAGVNVKGCFMTKEWEKYIPIVCSAHEMMRQASVLCDEAREIEKAGDAVIRKPHKKD.G.VIVSKTALISKPE...
A0A0F7DBG0_9EURY/2-272              .VKVGVLKMGAIGTALLVEYLLDERADRGDIEVRVVTSGAKMQPEEAV-VAEK.L...K..EFDPDVVIVISPNAALPGPKAAREAF--EGKP..VIVISDAPAKK.....A...K..DELAE....K.....GFGYILINADSMIGARREFLDPTEMALFNADVVRVLAATGAFRIVQEEIDKVIEAVKKGE...TPELPKIVITAEKAVKAGNFQNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAQLADEAREIEKSNDTVYRTPHSKD.G.EILKKFKLMEKPE...
A0A124G5N9_9EURY/24-301             .VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVITN.M...K..AWGPDFCVVVSPNGVLPGPTGAREELAKAGIP..VVVITDDITTK.....K...EqfDTLKA....S.....SFGYIIMKADAMIGARREFLDPVEMADYNSNLVKVLALTGAFTKLQVELDKVIDQVKAGKkgaDLVLPKVVMTSDKAVD-GAFNNPYAMAKARAAYEIAQSVAGVNVKGCFMTKEWEKYIPIVCSAHEMMRQAAALCDEARELEKGADCIIRSPHKKD.G.VIVTKTKLISKPE...
A0A0E3NUC0_9EURY/2-276              .VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVCGTGAKMGPDDAA-YTES.F...K..QWDADFVIIISPNAAAPGPTAARELW--KDKP..CIVVSDGPTKK.....D...A.rQALED....E.....GFGYIILPVDPLIGAKREFLDPVEMASFNADAMKVLSLCGVVRLIQEEFDKVADQVNAGNsgkELELPHIFAKPEKCVEHGGFANPYAKAKALAALHMAEKVAQVNFPACFMLKDIEQVCLATATGHEIMGAAAVLATQAREIEKSNDTVLRQPHAKN.G.TLLTKTKLYEKP-q..
A0A135VUY1_9ARCH/6-287              .FKLGVVKFGAIGAAPLLDLIFDERADRKDLEVRVFTSGAKLDEDSCVDATRM.V...I..DYKPQLVLSVSPNAALKGPAKSREMLHEAGLP..TITISDGPSEKgfykkG...E..DKKKVktvlD.....KQGFFILYADAMIGARREFLDPTEMVLFNSDIIRVLTNTGVMRLLQEEIYAVIESIKEGK...EPKMPTVKVTAEKAIAAGGFSNPYAAAKAYAALKISEAVADVTTKGCFVEQDPAKYIPLVAAGHEMMRIAAVLSDEARELEKASDTLLRTPHTSK.G.KLKKKTALAD---dl.
A0A0P7ZDL2_9EURY/3-275              .VKVGFIKLGNLGTSQVIDLLLDEIAAREGIAVRVFGTGAKMGKDEAA-ETAS.F...K..NWGPNFVVMISPNSSAPGPTAARDVW--KDTP..TIVVSDGPTKK.....E...D.rEKLEQ....A.....GFGYIILPVDPLIGAKREFLDCVEMATFNTDALKVLSICGAIRLVQTEIDKVIDQVAAGT..kPLVLPKILAKPDKCVESAGFNNPYAKAKALAALHIATKVAEIDFPACFVLKEADQVAIAAASGHEAMRAAARLADEAREMEKANDSVLRKPHAKD.G.RLLTKTKLLEKP-q..
A0A166CS26_9EURY/3-276              .VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVTPK.I...K..EFNPDFAIFISPNPGAPGPAKARELLSSYDIP..ALIIGDGPGMG.....K...R..EEMDE....Q.....GLGYIIVKADPMIGARRELLDPTEMASFNSDVIKVLALTGAYRTVQNAIDGMIADVEAGK...DVELPKIVLSRDVAVKAADFKNPYAKAKAMAAYEIATKVADIDTEGCFMVQDAEKYIPLVASAHEMIAVAAKLAEEAREIEKSNDTVVRTPHSGK.G.TTVSKTKLLDKP-a..
A0A101DQ41_9EURY/3-276              a-KIGVLKCGNLGTSPVIDLVLDERADRPNVEIRVMGSGTKMNPDDIEFVVPK.M...L..ELDRDFVIFISPNPGAPGPARARELLSEADVP..AMIVGDAPGLR.....V...K..DEIEE....Q.....GLGYIIVKADSMIGARREFLDPTEMAAFNADLMKVLALTGAYRVVHNTIDAMIADVEAGK...EIELPQLVITRDVAVEAADFQNPYAKAKAMAAYEIASKVADIDVEGCFMVQDPEKYIPIVASAHEMMSTAARLAEEAREIEKSNDTVRRTPHGKE.G.ETLSKRKLLEKP-s..
A0A0M0BS79_9ARCH/2-275              .VRITFLKIGYIGATNLIDALLDERASRKGISVRVISSGCKMDEEEAVEVAKL.A...A..SLPSDLYVVVSPSAGLPGPTAARGVLRETGKP..IIVVSDEPTRK.....I...S..KDLEE....G.....GFGYIVIYADPMIGAKQDFLDPVEMVLFNSDVLRVLAVTGVIRLIHSEIDRVIAQLEEGG...EVQLPRVVVDKEAALEHSGLENPYAHAKAMASFEAARRVANLSTEGTYRVEERERFLPILAAAHELMRQAALMADEAREVEKANDSVTRVVHLRS.G.ALRKKTELLGK--le.
A0A166CNE9_9EURY/12-285             .VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVTPK.V...K..EFNPDFAIFISPNPGAPGPAKARELLSSYDIP..AVIIGDAPGAG.....K...K..DELNE....Q.....GLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLALTGAYRIVQDAIDDLVDAADAGK...ELELPKIIITAEKAAEAAGFTNTYAKAKAIAAYTAAEKVADLDLKGCFMVKESDKYIPLVAAAHELIGVAAKLATEARDIEKSNDTVLRTPHGAN.G.STVKKTVLLEKP-v..
MTD_METMA/5-279                     .VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMAPADAA-DTES.F...K..QWNADFVVIISPNAAAPGPTAAREIW--KDVP..CIIVSDGPTKK.....E...A.rEAFEQ....E.....GFGYIILPVDPLIGAKREFLDSVEMASFNADAMKVLSICGVVRLIQEELDKVTEQVASGKsgkDLELPHIFAKPEKCVEHAGFANPYAKSKALAALHMAEKVAQVNFPACFMLKEIEQVCLTAAAGHEIMGAAAQLANQAREIEKSNDTVSRMPHAKN.G.AVLKKVRLYEKPE...
A0A101J2P9_9EURY/3-280              .VKVGIAKLGNIASGVMGELLLDERADREDIITFMATSGTKLQPEDIDRVVSN.M...K..AWGPDFCIVVSPNGVLPGPVKAREDLAAAGIP..CVVITDDVTTK.....K...EqfEALKA....S.....NFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLALTGAFRKMQMELDRVIDQVKAGKkgaDLALPKVVMTSDKAVE-GEFSNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAMFLCEEARNLEKGMDAVIRKPHKKT.G.EIVSKTTLISKPE...
Q12XF4_METBU/2-273                  a-KIGFIKLGNLGMSQVIDLVQDEIAAREGISVRVFGTGPKMGKDEAA-ETAA.L...K..EWDADFYVMISPNSSAPGPTAAREIY--KDVP..CIVISDGPTKK.....D...D.rQALED....A.....GFGYIIMTVDPLIGAKREFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDIVTAQVDEGK...EIVLPHILAKPEKCIERAGFSNPYAKAKALAALHMADKVAQINFPACFMMKEIEQVTLTTATAHEMMRAAAQLAIDAREIEKSNDTVLRQPHAKK.G.NILSKTALYEK--qq.
#=GC SS_cons                        E-EEEEEEES--HHHHHTTGGGSTTS--SSEEEEEEEEET--SHHHHHHHHHHHHHHHH..HH--SEEEEE-S-TTSHHHHHHHHHHHHSSS-..EEEEEEGGGGG.....G...H..HHHHH....T.....T-EEEEETTS------TTT--HHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTT--.-GGGS-EEEESGGGGGGSS--SSHHHHHHHHHHHHHHHHHHHHHHHHHHT---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT---B--B-TT.S.SB--BSSTTS---...
#=GC seq_cons                       .VKlGllKhGNIGoSsll-LlLDERADRpsIsVRVhuSGuKMssEps-clspp.h...c..pasPDFsIhlSPNsusPGPstAREhLtttslP..sIlIoDuPspK.....t...c..-tlcc....p.....GhGYIIlpuDsMIGARREFLDPsEMA.FNuDllKVLAhTGAhRllQpplDcVIcplcuGK...-lcLP+lllss-KAV-tusFsNPYA+AKAhAAachAppVAslsscGCFMhK-hEpYlPlVAuAHEMMRsAApLA-EAREIEKusDoVlRpPHs+c.G.pllsKspLh-KP....
//
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