GenomeNet

Database: Pfam
Entry: MTD
LinkDB: MTD
Original site: MTD 
#=GF ID   MTD
#=GF AC   PF01993.13
#=GF DE   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase
#=GF AU   Enright A, Ouzounis C, Bateman A
#=GF SE   Enright A
#=GF GA   25.00 25.00;
#=GF TC   142.50 142.40;
#=GF NC   19.50 19.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7852356
#=GF RT   Cloning, sequencing, and transcriptional analysis of the
#=GF RT   coenzyme F420- dependent
#=GF RT   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene
#=GF RT   from Methanobacterium thermoautotrophicum strain Marburg and
#=GF RT   functional expression in Escherichia coli. 
#=GF RA   Mukhopadhyay B, Purwantini E, Pihl TD, Reeve JN, Daniels L; 
#=GF RL   J Biol Chem 1995;270:2827-2832.
#=GF DR   INTERPRO; IPR002844;
#=GF DR   SCOP; 1qv9; fa;
#=GF CC   This enzyme family is involved in formation of methane from
#=GF CC   carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420
#=GF CC   [1].
#=GF SQ   55
#=GS MTD_METST/2-276     AC Q2NHQ2.1
#=GS F0T7A4_METSL/2-276  AC F0T7A4.1
#=GS D3RXG7_FERPA/1-272  AC D3RXG7.1
#=GS D3E118_METRM/2-276  AC D3E118.1
#=GS D7EB48_METEZ/1-277  AC D7EB48.1
#=GS Q648F7_9ARCH/3-276  AC Q648F7.1
#=GS D7DR53_METV3/2-277  AC D7DR53.1
#=GS D1YY63_METPS/2-275  AC D1YY63.1
#=GS D5VSM6_METIM/1-274  AC D5VSM6.1
#=GS G6FHR5_9EURY/2-279  AC G6FHR5.1
#=GS F8ALX1_METOI/2-277  AC F8ALX1.1
#=GS Q0W2P5_UNCMA/2-274  AC Q0W2P5.1
#=GS MTD_METTH/2-276     AC Q50501.3
#=GS MTD_METAC/4-279     AC Q8THT2.1
#=GS MTD_METS3/2-275     AC A5UMI1.1
#=GS D3S659_METSF/2-277  AC D3S659.1
#=GS MTD_METKA/3-283     AC P94951.3
#=GS MTD_METKA/3-283     DR PDB; 1U6I D; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6I C; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF G; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1QV9 C; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I B; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQE F; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J G; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6J B; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ D; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQE A; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQF E; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1QV9 A; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J K; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6I F; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF L; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ E; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6K B; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6I A; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6K C; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF K; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I K; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQE E; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1QV9 B; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I J; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQE D; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I E; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF D; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J F; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6J D; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6J C; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF C; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ B; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J J; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF J; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I I; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ A; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J L; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6J I; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF A; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6I G; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6I L; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQE B; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J A; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 1U6I H; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF F; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ C; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQZ F; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J H; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF B; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6K A; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF H; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 3IQE C; 3-283;
#=GS MTD_METKA/3-283     DR PDB; 1U6J E; 3-282;
#=GS MTD_METKA/3-283     DR PDB; 3IQF I; 3-283;
#=GS A9A6W8_METM6/2-277  AC A9A6W8.1
#=GS MTD_METMJ/2-280     AC A3CSZ5.1
#=GS Q64AB6_9ARCH/3-276  AC Q64AB6.1
#=GS B9AFI6_METSM/2-275  AC B9AFI6.1
#=GS G0H2S2_METMI/2-277  AC G0H2S2.1
#=GS F4BZ98_METCG/1-272  AC F4BZ98.1
#=GS MTD_METMA/4-279     AC Q8PXV8.1
#=GS A0B7C4_METTP/1-273  AC A0B7C4.1
#=GS D2ZP28_METSM/2-275  AC D2ZP28.1
#=GS G7WNZ3_METH6/1-272  AC G7WNZ3.1
#=GS MTD_METLZ/2-280     AC A2SPK1.1
#=GS MTD_METMP/2-277     AC Q6M099.1
#=GS F6D7B4_METSW/2-276  AC F6D7B4.1
#=GS H8I793_METCZ/2-275  AC H8I793.1
#=GS MTD_METM5/2-277     AC A4FZG7.1
#=GS D5EAK3_METMS/1-276  AC D5EAK3.1
#=GS Q46DH9_METBF/1-276  AC Q46DH9.1
#=GS F2KNE0_ARCVS/1-272  AC F2KNE0.1
#=GS H1KZN0_9EURY/8-283  AC H1KZN0.1
#=GS E1RKC0_METP4/2-280  AC E1RKC0.1
#=GS MTD_METPE/2-280     AC B8GJQ7.1
#=GS C9RF17_METVM/2-277  AC C9RF17.1
#=GS MTD_ARCFU/2-273     AC O29544.3
#=GS D2RET8_ARCPA/1-253  AC D2RET8.1
#=GS MTD_META3/2-277     AC A6UWS1.1
#=GS D1JH91_9ARCH/3-276  AC D1JH91.1
#=GS MTD_METB6/2-279     AC A7I5N7.1
#=GS MTD_METTM/2-276     AC P55300.3
#=GS MTD_METJA/2-277     AC Q58441.1
#=GS MTD_METM7/2-277     AC A6VJ05.1
#=GS E3GZ78_METFV/2-276  AC E3GZ78.1
#=GS Q12XF4_METBU/1-273  AC Q12XF4.1
#=GS H1L1K4_9EURY/1-80   AC H1L1K4.1
#=GS C7P934_METFA/2-277  AC C7P934.1
#=GS MTD_METHJ/2-280     AC Q2FU89.1
#=GS MTD_METVS/2-276     AC A6URY5.1
#=GS F7XNL9_METZD/1-278  AC F7XNL9.1
#=GS H1YWR8_9EURY/2-280  AC H1YWR8.1
MTD_METST/2-276                .VVKIGIVKVGNIGTSVLIDMILDERADREDIDVRTISSGAKMGKNQMD...DVLPKI-DEY..NPDVIIFISPDPGAKSPSSARETLSKKNIPTIVIGD.GPGER.A.I..G..S...MKEQGLGYIIVKADSMIGARREFLDATEMAVFNSDVLMVLSTTGVFRLIHKTLDKVIRDIDEDK...LYSLPELVITAENAVDAADFKNPYAKSKAIAAYSIACQVSSMNVRACFKTKDYHVYIPLVSAAHEMMSAASKLAYEAREIEKSNDTVVRTAHRRNGSILYGTSLN----dnke
F0T7A4_METSL/2-276             .VVKIGIIKCGNIGTSPVIDLLLDERADRPNIDTCVVGSGAKMNPEEIE...KAVPLML-EM..DRDFVIFISPNPGAPGPAKARELLSAADVPAIIIGD.APGLR.S.K..D..E...MDEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLALTGAYRVVQNTIDAAVTAVESGE...TLELPKVVITRDKAVEAAAFGSPYAKAKAMAAYEIATKVADIDVEGCFMVRDAEKYIPLVASAHEMLGVAAKLASEARDIEKANDTVVRTPHGGKGQTLSKVALADKPE....
D3RXG7_FERPA/1-272             m-VKVGILKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPE--E...AKIAEKLKEF..DPDLVLVVSPNAALPGPKAAREAF--EGKPVIVISD.APAKK.A.K..E..E...FEQKGFGYILVNADSMIGARREFLDPTEMALFNADVVKVLAATGAFRIVQEEIDKVIEALKKGE...KPELPKVVITAERAVEAAKFSNPYAKAKAMAAYFIAEKVADVDVRGCFIEKDPEKYIPLVAAAHEMMRIAAKLADEAREIEKSNDTVFRNPHARDGKILSKTKLMEKP-q...
D3E118_METRM/2-276             .VVKIGIVKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVE...DVVPK-LDQF..DPDFCIFISPNPGAPGPARARELLSEKDLPAIIIGD.APGKG.K.K..D..E...MDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQKTLDAVIAAADAGE...EIELPKLIVTAEKAVEAAGFANPYAKAKAIAAYEMAGAVAGLDMKGCFMTKGFENFIPLVAAAHEIASAAAKLAQEAREIEKSNDTVLRTPHMKEGNLGCKVDLISKP-v...
D7EB48_METEZ/1-277             m-VKVGFIKLGNLGMSQVVDLLEDEIAAREGITTRVYGTGPKMSKEDA-...ADTEAFKEEF..DPDFVIIISPNASTPGPTEARQLW--KDKPCLIISD.GPTKK.DdR..Q..A...IEDEGFGYIILPVDPLIGAKTEFLDPEEMASFNSDVMKVLSTCGAVRLVQEELDKLTSQVDEGKsgdEIEMPHIYAKPQTCIERSGFSNPYAKAKALAALHMAEKVSQINLPACFMLKDLEEVAFTAATGHEMIRAAAELAVEAREIEKTNDTVLRKPHSKKGKVLSKTKLYEKP-q...
Q648F7_9ARCH/3-276             .IVKIGFVKLGNIGISRIVDLLLDERADREDIDVRVLGTGAKMTPE--N...AADTSRLLDW..DPDVVVITSPNAALPGPKSAREMVKEKGKPCIVISD.APAKK.A.V..D..K...LKEGGFGYIIIPGDPMIGARREFLDPVEMSLFNADVLSVLSITGVAKLVQEEIDAVIEAIKKGE...EVKVPQIIATAERAVERAKFSNPYAKAKAIAAYSMAEKVAELDVKGCFMMKNPEEYVPVVAAAHELLREAAKLAFEAREVEKQTDSLVREPHSRTGEIMKKEKLMEKP-s...
D7DR53_METV3/2-277             .VVKVGIIKCGNIGMSPLVDLSLDERADRNDIDVRVVGSGAKMGPEQVE...EVTKKMIEDI..KPDFVLYIGPNPAAPGPKVARELLSAADIPAVIIGD.APGIK.D.K..D..A...MAEQGLGYILIKCDPMIGARRQFLDPVEMSMFNADVVRVLAGTGAVRVVQNAIDAMIYAVEEGK...EIELPKIIVTDAKAVAAAEFSNPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMDKYIPIVASAHEMIRYAAKLVDEARELEKATDGVSRKPHAGPGAILNKSKLMEKPE....
D1YY63_METPS/2-275             t-ARVGIVKLGNLGTSRYIDLILDERADR-DIYVRTVGTGAKLGEAEAD...EAVAKIL-EF..KPQLCIVISPNGALPGPTKAREAIKAAGVPTIAISD.VPMMK.V.K..D..D...LKAKGLGYFIVKCDSMIGARRQFLDPTEMVLFNADMTKVLAETGVVRLIQTELDKCIDMINAGQ...PVTVPQIVIDAAKAVPMAGYTNPYAQAKAFAAFAAAEKVGDLDLLGCFMQKEMEQYIITVASAHELLRTAALLCDQARELEKGGNSIKRTPHAADGKVLSKTTLVSKPE....
D5VSM6_METIM/1-274             m-VKVGIVKCGNIGTSLVVDLALDERAER-DINVLVYGSGAKMNPESVE...YVVKKMI-EE..KPDLIIYIGPNPAAPGPRKARELLSECKIPSIIIGD.APGIK.V.K..D..E...MEKEGLGYILIKGDPMIGARREFLDPTEVALFNSDILKVLAVTGVVRLVQEEIDRVIEYIKEGK...EPELPRIVVDAEKAVERMEYSNPYAKAKAIASYNMAEEVANIDVKACFMVKEPERYIILAASAHELLRQAAKLADEARELEKATDMVSRKPHAKDGRILSKRKLLEKP-q...
G6FHR5_9EURY/2-279             .VVKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDID...RVVNNMI-AW..KPDFAIVVSPNGVLPGPTGARERLAAAGIPTVFITDdVTTKK.E.W..A..E...IKDGKFGYIIMKGDAMIGARREFLDPIEMADYNGNLIKVLSVTGAFRKLQTALDQIIDQVKAGKkgaELVLPKLVVTSDKAVE-GEFTNPYAMAKARAAYEIAQSVAMVNVKGCFMTKEWEKYIPIVCSAHEMMRIAAALCDEARELEKACDGVVRKPHKKDGVIVSKTKLISKPE....
F8ALX1_METOI/2-277             .VVKIGIIKCGNIGMSPVIDLALDERADRGNIDVRVLGSGAKMGPEQVE...EVTTKMVEEI..KPDFVIYIGPNPTAPGPKKAREILSKSGIPSVIVGD.APGIR.E.K..D..K...MTEEGLGYILIKCDPMIGARRQFLDPVEMAMFNADVLRVLAGTGALRVVQNAIDDMIEAIEAGN...KPELPQIVVTDKKAVEAANFSNPYAKSKAMAAFAMAEKVADIDVKACFMTKGMENYIPMVAASHELIRYAAKLVDEARELEKAMDTVSRKPHAADGKRLNKTKLMEKPE....
Q0W2P5_UNCMA/2-274             t-VRVGIVKLGNIGTSRFIDLVLDERADR-DIYVRTVGAGAKMGEAEAE...EMK-KI-IDF..KPQFCIVISPNATVPGPTKAREMLKEAGIPTIVISD.SPVLK.I.K..D..D...LKAKGFGYFVVKCDPMIGARRQFLDPTEMVLFNADVLKVLANTGVVRLIQKELDAVIEGFAAGQ...TPALPQIVISADKAVAAAGYKNPYAKAKAMAAFVAAEKVADIDLQGCFMQKEMEQYIPTVASAHELLREAAKLSDEARELEKATDAILRTPHAADGKVLSKTQLMLKPE....
MTD_METTH/2-276                .VVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIE...RAVPTML-EM..DRDFVIFISPNPGAPGPAKARELLSEADVPAMIIGD.APGLR.V.K..D..E...IEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGK...APELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKLAVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE....
MTD_METAC/4-279                m-VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMGPA--D...AADTESFKQW..NADFVVMISPNAAAPGPTAAREIW--KDVPCIVVSD.GPTKKeA.R..E..A...LEQEGFGYIILPVDPLIGAKREFLDPVEMASFNSDAMKVLSSCGVVRLIQEELDRVTEQVASGKsgeDLELPHIFAKPEKCVEHAGFANPYAKAKALAALHMAEKVAQVNFPACFMLKEVEQVCLTAAAGHEIMGAAAILATQAREIEKSNDTVFRQPHAKNGTLLKKVKLYEKPE....
MTD_METS3/2-275                .VVKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVE...DVVPKV-DQF..DPDFCIFISPNPGAPGPAKARELLSEKDIPAIIIGD.APGKG.K.K..D..E...MDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQNTIDGVIDGAAAG-...NIELPKLIITAEKAVEAAGFENPYAKAKAIAAYEMAGAVANLDMKGCFMTKGFENFIPLVAAAHEMAASAAALADEAREIEKGNDSVLRTPHMKEGNTGCKTDLISKPE....
D3S659_METSF/2-277             .VVKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVE...EVTKKMVEEV..KPDFIIYIGPNPAAPGPKKAREILSQSGIPAVIIGD.APGLR.V.K..D..E...MEQQGLGYIIIKCDPMIGARREFLDPVEMALFNSDVIRVLAGTGALRIVQEAIDKMIDAVKEGK...KPELPKIVITEQKAVEAMEFTNPYAKAKAMAAFVIAEKVGDVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKAMDTVSRKPHHPEGKILSKKALMEKP-q...
MTD_METKA/3-283                .VAKAIFIKCGNLGTSMMMDMLLDERADREDVEFRVVGTSVKMDPECVEaavEMALDIAEDF..EPDFIVYGGPNPAAPGPSKAREMLADSEYPAVIIGD.APGLK.V.K..D..E...MEEQGLGYILVKPDAMLGARREFLDPVEMAIYNADLMKVLAATGVFRVVQEAFDELIEKAKEDEi.sENDLPKLVIDRNTLLEREEFENPYAMVKAMAALEIAENVADVSVEGCFVEQDKERYVPIVASAHEMMRKAAELADEARELEKSNDAVLRTPHAPDGKVLSKRKFMEDPE....
#=GR MTD_METKA/3-283     SS    .-EEEEEEEES--HHHHHTTGGGSTTS--SSEEEEEEEEET--SHHHHHHHHHHHHHHHHHH..--SEEEEE-S-TTSHHHHHHHHHHHHSSS-EEEEEE.GGGGG.G.H..H..H...HHHTT-EEEEETTS------TTT--HHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTT--.-GGGS-EEEESGGGGGGSS--SSHHHHHHHHHHHHHHHHHHHHHHHHHHT---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT---B--B-TTSSB--BSSTTS---....
A9A6W8_METM6/2-277             .VVKIGILKCGNIGMSPVIDLCLDERADRNDIDVRVLGSGAKMGPEQVE...EVAKKMVEEV..KPDFIVYIGPNPAAPGPKKAREILSAGGIPTVIIGD.APGIK.D.K..D..A...MAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDEMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKTADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKLVDEARELEKATDAVSRKPHAGDGKILNKCKLMTKPE....
MTD_METMJ/2-280                .VVKVGIAKLGNIASGVMGELLLDERADREDMITFMATSGTKLQPEDIE...RVVSNMK-AW..GPDFCIVVSPNGVLPGPTQAREDLAAAGIPCIVITD.DVTTK.K.EqfE..A...LKASNFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLALTGAFRKMQMELDKVIDQVKAGKkgaDLALPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQSVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAMLLCEEARTLEKGVDAVIRKPHKKTGEIVSKTALISKPE....
Q64AB6_9ARCH/3-276             .VVKIGFVKLGNIGASRIVDLLLDERADREDIDARVLGTGAKMTPEH--...ATDTSRLLDW..DPDLVVISSPNAALPGPKRAREMVKEKGKPCIVISD.APAKK.A.V..N..D...LKENGYGYIIIPGDPMIGARREFLDPVEMSLFNADVLSVLTITGVVKLMQEELDAVIDAIRKGG...EVKLPQIIATVEKSVERAQFSNPYAKAKAIAAYSMAEKVAELDVKGCFMMKDPKEYVPIVAAAHELLREAAKLAYEARDMEKQTDSLVRMPHARTGEILKKVKLLDKP-s...
B9AFI6_METSM/2-275             .VVKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVE...DVVPKV-DQF..DPDFCIFISPNPGAPGPAKARELLSEKDIPAIIIGD.APGKG.K.K..D..E...MDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQNTIDGVIDGAAAG-...NIELPKLIITAEKAVEAAGFENPYAKAKAIAAYEMAGAVANLDMKGCFMTKGFENFIPLVAAAHEMAASAAALADEAREIEKGNDSVLRTPHMKEGNTGRKTDLISKPE....
G0H2S2_METMI/2-277             .VVKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMGPEQVE...EVAKKMVEEI..KPDFIVYIGPNPAAPGPKKAREILSAGGIPAVIIGD.APGIK.D.K..D..A...MAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHEAIRYAAKLVDEARELEKATDAVSRKPHAGAGQILNKCKLMEKPE....
F4BZ98_METCG/1-272             m-FKIGFVKLGNIATSTAIDLSLDEIAERTDIEFKIISFGPKMTEK--E...GKGAEELKAW..QPQLVVISSPNAATAGPTAAREAY--RGIPTIIISD.GPSKKeA.R..E..A...LSAEGYGYIILPMDPLIGAKREFLDPAEMALFNSDALRVLAACGAIRLVEEELDRTIASIISGQ...-AKLPTILATPEKCAERMHFSNPYAQAKAMGALYMAQTVASIDAAACFRLKELKPIALTAAAGHEVMRAAARLADEARELEKSNDTVSRQPHARTGELMQKLSLLDKPE....
MTD_METMA/4-279                m-VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMAPA--D...AADTESFKQW..NADFVVIISPNAAAPGPTAAREIW--KDVPCIIVSD.GPTKKeA.R..E..A...FEQEGFGYIILPVDPLIGAKREFLDSVEMASFNADAMKVLSICGVVRLIQEELDKVTEQVASGKsgkDLELPHIFAKPEKCVEHAGFANPYAKSKALAALHMAEKVAQVNFPACFMLKEIEQVCLTAAAGHEIMGAAAQLANQAREIEKSNDTVSRMPHAKNGAVLKKVRLYEKPE....
A0B7C4_METTP/1-273             m-FKIGFIKLGNIASSLVVDLALDEIAERTEIESKVVSHGPKMSRGEGE...RLAEEMR-AW..GPQMVVVVSPNAATPGPTAARSML--KGIPLIVISD.GPTKKeA.R..D..A...METEGFGYIILPMDPLIGAKREFLDPAEMAIFNADALKVLSICGAVRLVQEEIDRAIASVAAG-...SPQLPHILATPELCAERMDFANPYARAKAIAALYMAQTAASIDAQACFRLKELEAIALAAAAGHEVIRAAARLADEARELEKSGDTVSRKPHARSGDLLVKRKLLEKP-a...
D2ZP28_METSM/2-275             .VVKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVE...DVVPKV-DQF..DPDFCIFISPNPGAPGPAKARELLSEKDIPAIIIGD.APGKG.K.K..D..E...MDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQNTIDGVIDGAAAG-...NIELPKLIITAEKAVEAAGFENPYAKAKAIAAYEMAGAVANLDMKGCFMTKGFENFIPLVAAAHEMAASAAALADEAREIEKGNDSVLRTPHMKEGNTGRKTDLISKPE....
G7WNZ3_METH6/1-272             m-FKIGFIKLGNVASSLVADLALDEIAERTDVEVRSLSFGAKMTVK--E...AEMSAELKGW..GPQLVVIVGPNAATPGPTAARALY--RDVPTIVISD.GPSKKeA.R..E..A...LEAEGFGYIILPFDPLIGAKREFLDPAEMALFNSDALKVLSICGSVRLVQEELDGAMASIISG-...APRLPTILSSPEGCTDRMAFRNPYARAKAIGALHMAQTVAGIDAAACFRLKELDRIALTAAAGHEVMRAAARLADEARELEKSTDSVSRRPHARSGAILAKTGLLDKPE....
MTD_METLZ/2-280                .VVKVGVAKLGNIAAGVMAELLLDERADREDMMTFMATSGTKLQKEDVD...RVVSNL-KAW..QPDFAIVVSPNGVLEGPVGAREDLKAAGIPTIVITD.DVTTK.K.EgwE..A...LKASGFGYIIVKADAMIGARREFLDPVEMADYNGNLVKVLALTGAFRKLQLELDKVIDQVKAGKkgaELELPKLVLNSDNST-KGEFTNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWTDYVPIVASAHEMMRAAANLCDQARELEKGCDGVIRKPHKKTGEIVSKVALISKPE....
MTD_METMP/2-277                .VVKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMGPEQVE...EVAKKMVEEI..KPDFIVYIGPNPAAPGPKKAREILSAGGIPAVIIGD.APGIK.D.K..D..A...MAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKLVDEARELEKATDAVSRKPHAGAGKILNKCKLMEKPE....
F6D7B4_METSW/2-276             .VVKIGVIKCGNLGTSPVIDLMLDERADRPNISVKSFGSGAKMGPEEIE...EVVPKVA-DL..DAAFVIFISPNPAAPGPAKARELLSAMDVPAIIVGD.GPGAR.V.K..D..E...MNEQGLGYILVKGDPMIGARREFLDPTEMASFNADVIKVLAATGAYRCVQKTLDALIAAAEAGE...AIEVPKLVLTRDKAIAAAEFKNPYAKAKAMAAYTIAEKVADIDVEGCFMTKDAEKYIPIVASSHEMIAVAAKLAAEAREIEKANDTVLRTPHSGKGQLVSKTTLMSKPE....
H8I793_METCZ/2-275             t-VRVGVVKLGNLGTSRYIDLILDERADR-DIYTRVVGTGTKLGEPDAE...EAATKIL-DF..KPQLAIVISPNGALPGPTKAREMIKAAGVPTIMISD.APAAK.V.K..D..D...LKAKGFGFFIIKCDSMIGARRQFLDPTEMVLFNADLQKVLADTGVVRLLQKELDRVVAEIASGA...TPNLPQIVVDSNKALAESGYKNPYARAKAFAAFAAAEKVGDIDVLGCFVQKEMEQYVITVASAHELLRAAAMLCDEAREIEKSGDSVYRTPHANDGKILSKSTLVSKPE....
MTD_METM5/2-277                .VVKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMNPDQVE...EVAKKMVEEV..KPDFIVYIGPNPAAPGPKKAREILSAGGIPAVIIGD.APGIK.D.K..D..A...MAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKLVDEARELEKATDAVSRKPHAGAGQILNKCKLMEKPE....
D5EAK3_METMS/1-276             m-VKVGFIKLGNLGMSQVIDLVQDEIAAREGITTRVFGTGPKMDKE--T...AASTEELKAW..DPDFVVMISPNASAPGPKSARELW--KDYPCIVVSD.GPTKK.DdR..Q..A...LEDAGFGYIIMTVDPLIGAKTEFLDAVEMASFNSDAMKVLSTCGVVRLLQEELDAVTAQVDEGKsgaDLELPHILAKPQKCIERAGFNNPYAKAKGLAALHMASKVAEVNMPACFILKEIEDVTLTAATGHELMRAASQLAIEAREIEKANDSVFRQPHSKKGFQLQKTKLYEKP-q...
Q46DH9_METBF/1-276             m-VNIGFIKMGNLGMSQVINLVQDEIAAREGITVRVFGTGAKMSPA--E...AAASESFKQW..NADFVIIISPNAAAPGPKAAREIW--KDVPCIVVSD.GPTKKeA.R..E..A...LENNGFGYLILPVDPLIGAKREFLDPVEMASFNSDAMKVLSVCGVVRLVQEELDKVTDQVASGKsgkELELPHIFAKPEKCVEYAGFANPYAKAKALAALHMAEKVAQVNFPACFMLKEIDQVCLTAAAGHEIMGAASQLAIQAREIEKSNDTVLRQPHAKNGTLLKKVKLYQKPE....
F2KNE0_ARCVS/1-272             m--RIGIIKLGAIATALLIDYMLDERADREDIDVRTITSGSKLRER--D...AEIVDKMREF..NPDLVIVASPNAALPAAKLARDALKAEGKPVIVISD.APAKK.V.K..D..E...LEAEGFGYILVNADSMIGARREFLDPTEMCLYNSDVIKVLAATGAFRAVQLAVDEAIESAKAGK...-PKLPRLIIDAEAAVNAGNFSNPYARAKAMAAYTIAEKVAAVTTKACFVEKDAEKYIPMVAAAHEMMRYAAKLAEEAREIEKSSDAVYRTPHAKDGRVLSKWGLMEKP-s...
H1KZN0_9EURY/8-283             .VVKIGILKCGNIGMSPIIDLCLDERADRKDIDVRVLGSGAKMDPTSVE...EVATKMVNEI..KPDFIIYIGPNPAAPGPKKAREILSQSDIPAVIVGD.APGLR.A.K..D..E...IEKEGLGYIIIKCDPMIGARRQFLDPVEMALFNADVIRVLAGTGALRIVQNAIDEMIESVKEGK...EVPLPKIVINEEKAVEAMEFTNPYAKAKAMAAFTIAEKVGDVDVKGCFMVKEMERYVPIVASAHEMLRYAAMLVDEARELEKAMDAVSRKPHHPEGKVLGKKKLMEKPE....
E1RKC0_METP4/2-280             .VVKVGIAKLGNIASGVMAELLLDERADREDMETFMATSGTKLQEKDID...RVVENMK-AY..GPDFCIVVSPNGVLPGPKGAREALAAAGIPCVVITD.DITTK.-.K..D..EfaaLKETSFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAVTGAFRKLQIALDEVIDQVKEGKkgaDLVLPKIVMSSDKAVE-GEFTNPYAYAKARAAYEMAQSVAGINVKGCFMTKGHENYTPIVASAHEVMRQAMLLCEEAREIEKSCDGVIRKPHKSDGTRVEKVKLIDKP-w...
MTD_METPE/2-280                .VVKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDID...RVVSTMK-AW..EPDFCIVVSPNGVLPGPVGARDELLKAGIPCVVITD.DITTK.K.EgwE..A...LKASSFGYIIMKADAMIGARREFLDPVEMADFNGNLVKVLALTGAFRKLQTELDKVIDQVKEGKkgaDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAAALGDEAREIEKAGNGIIRKPHKKDGTIVSKITLISKPE....
C9RF17_METVM/2-277             .VVKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVE...EVTKKMVEEV..KPDFIIYIGPNPGAPGPKKAREILSESGIPAVIIGD.APGLR.V.K..D..E...MEQQGLGYIIIKCDPMIGARREFLDPVEMALFNSDVLRVLAGTGALRVVQEAIDKMIDAVKEGK...EIELPKIVINEQKAVEAMEFTNPYAKAKAMAAFVIAEKVGDVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKANDSVSRKPHHPEGKRLNKKALMEKPE....
MTD_ARCFU/2-273                .VVKVGVLKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPE--E...AVVAEKLKEF..DPDVVIVVSPNAALPGPKAAREAF--EGKPVIVISD.APAKK.A.K..D..E...LKEKGFGYILINADSMIGARREFLDPTEMALFNADVVKVLAATGAFRLVQEAIDKVIEDIKAGK...QPELPQIVVTAEKAVEAGKFSNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAILADQAREIEKSNDTVFRNPHAKDGKILGKTQLMAKPE....
D2RET8_ARCPA/1-253             m--RIGIAKLGAIGSAVLLEYCLDELAMRGDIETFVVSSGSKIKVEVLE...E-----LEKR..DFDLKIVTCPNAEKF----LKDVN--LSDRVIVITD.RA---.S.K..D..W...LDSLNWGYIVVKADAMIGARREFLDPTEMVLYNSDLLKVLAVTGIIRLLQYEINRA------LK...EDYLPKVVVDYNTAVKFAGFCNPYARAKAIASYIIAENISKITHKACFVEKDAENYITLCATAHEMMRIAGKLADEAREIEKSNDSVLRTPHSKSGEILKKVGL-----ydv.
MTD_META3/2-277                .VVKIGIIKCGNIGMSPLIDLALDERADRTNIDVISIGSGAKMGPNQVV...EVTTKMVEDI..KPDFIIYVGPNPAAPGPAKAREILSASDIPSVIIGD.APGIK.A.K..D..K...MAEEGLGYILIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGAARVVQNAIDDIVEAIEAGN...EIELPKIVVTDAKSVAAAEFSNPYAKAKAMAAFAMAEQVANIDVKGCFMTKEMEKYIPIVASAHEMIRTAAKLVDEARELEKATDSVSRKPHGADGKRLNKTKLMEKPE....
D1JH91_9ARCH/3-276             .VVKIGFVKLGNIGASRIVDLLLDERADREDIDARVLGTGAKMTPE--H...AADTSRLLDW..DPDLVVITSPNAALPGPKRAREMVKEKGKPCIVISD.APAKK.A.V..N..D...LKENGYGYIIIPGDPMIGARREFLDPVEMSLFNADVLSVLTIAGVVKLMQEELDAVIDAIRKGG...DVKLPQIIATAEKSVERAQFSNPYAKAKAIAAYSMAEKVAELDVKGCFMMKDPKEYVPIVAAAHELLREAAKLAYEARDMEKQTDSLVRMPHARTGEILKKEKLLEKP-s...
MTD_METB6/2-279                .VVKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDID...RVVSNMK-AW..KPDFAIVVSPNGVLPGPTGAREQLAAAGIPVIIITDdVTTKK.E.W..E..E...VKNSKFGYIIMKADSMIGARREFLDPIEMADFNGNLVKVLAITGAFRKLQLALDKVIDQVKAGKkgtEIELPKIVMTTDKAVD-GEFTNDYALAKARAAHEIAIAVAGQNVKGCFMTKEWEKYIPIVASAHEMMRIAAVLCDEAREIEKAGDGILRQPHKKDGVLVRKTKLVAKF-e...
MTD_METTM/2-276                .VVKIGIIKCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIE...RAVPTML-EM..ERDFVIFISPNPGAPGPAKARELLSAADVPAMIIGD.APGLR.V.K..D..E...IEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGK...APELPQVVIDTDKAVEAAGYTNPYAKAKAMAAYEIATKVADIDVRGCFMVQDPDQYIPIVASAHEMLSAAAKLAIEAREIEKANDTVLRTPHGKEGKTLSKKDLLAKPE....
MTD_METJA/2-277                .VVKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVE...EVTKKMVEEV..KPDFIIYIGPNPAAPGPKKAREILSQSGIPAVIIGD.APGLR.V.K..D..E...MEQQGLGYIIIKCDPMIGARREFLDPVEMALFNADVIRVLAGTGALRIVQEAIDKMIDAVKEGK...EIELPKIVITEQKAVEAMEFTNPYAKAKAMAAFTIAEKVGDVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKAMDAVSRKPHHPEGKRLSKKALMEKPE....
MTD_METM7/2-277                .VVKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMGPEQVE...EVAKKMVEEV..KPDFIVYIGPNPAAPGPKKAREILSAGGIPTVIIGD.APGIK.D.K..D..A...MAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVDAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHEAIRYAAKLVDEARELEKATDAVSRKPHAGEGKILNKCKLMAKPE....
E3GZ78_METFV/2-276             .VVKIGVIKCGNIGTSPVIDLLLDERADRPNIDVRVIGSSAKMNPEQVE...DVVPKML-DM..DRDLVIFISPNPGAPGPAKARELLSESDVPSIIIGD.APGKR.V.K..D..E...IEKQGLGYIIVEADPMIGARREFLDPTEMASFNADVIKVLACTGAYRLIHKTLDDLISDLEAGK...EIELPKLIIDSEKAVEAGEFENPYAKAKAMAAYEIAAKAADLDVKGCFMVQDPEKYIPIVASAHEMVSIAAKLASEAREIEKSNDTVKRTPHGKKGELLEKVELMAKP-k...
Q12XF4_METBU/1-273             m-AKIGFIKLGNLGMSQVIDLVQDEIAAREGISVRVFGTGPKMGKD--E...AAETAALKEW..DADFYVMISPNSSAPGPTAAREIY--KDVPCIVISD.GPTKK.DdR..Q..A...LEDAGFGYIIMTVDPLIGAKREFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDIVTAQVDEGK...EIVLPHILAKPEKCIERAGFSNPYAKAKALAALHMADKVAQINFPACFMMKEIEQVTLTTATAHEMMRAAAQLAIDAREIEKSNDTVLRQPHAKKGNILSKTALYEK--qq..
H1L1K4_9EURY/1-80              .------------------------------------------------...----------..------------------------------------.-----.-.-..-..-...----------------------------------------------------------------...-----------------------------MAAFTIAEKVGDVDVKGCFMVKEMERYVPIVASAHEMVRYAAKLVDEARELEKAMDAVSRKPHHPEGNVLGKKKLMEKPE....
C7P934_METFA/2-277             .VVKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVE...EVTKKMVEEV..KPDFIIYIGPNPAAPGPKKAREILSQSGIPSIIIGD.APGLR.V.K..D..E...MEQQGLGYIIIKCDPMIGARREFLDPVEMALFNSDVLRVLAGTGTLRVVQEAIDKMIDAIKEGK...EPELPRIVINEQKAVEAMEFTNPYAKAKAMAAFVIAEKVADVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKAMDAVSRKPHHPEGKRLSKKALMEKP-q...
MTD_METHJ/2-280                .VVKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDID...RVVTNMK-AW..GPDFCIVVSPNGVLPGPKGAREALAAAGIPCVVITD.DITTK.K.EewE..A...LKASEFGYVIMKGDSMIGARREFLDPIEMADYNGNLIKVLSITGAFRKLQVALDEVIDQVKAGKkgkDLALPKLVMTSDKAVE-GEFSNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGFENYTPIVASAHEMMRQAMLLCEEAREMEKATDAVIRKPHKNDGTRVAKKTLISKPE....
MTD_METVS/2-276                .VVKIGILKCGNIGMSPIIDLCLDERADRNDIDVRVLGSGAKMNPDQVE...EVSKKMV-EE..KPDFIVYIGPNPAAPGPKKAREILAASGIPSVIIGD.APGIK.D.K..D..A...MAEQGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDEMVFAVEEGK...EISLPKIVITEQKAVDAMDFANPYAKAKAMAAFVMAEKTADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKMVDEARELEKATDAVSRKPHAGDGKILNKCKLMEKPE....
F7XNL9_METZD/1-278             m-AKIGFIKLGNLGISQVIELVQDEIAAREGISIRVFGTGPKMGKD--E...AASTEQFKDMswDADFYVIISPNASAPGPTAAREIW--KDVPCIIVSD.GPTKK.DdR..Q..A...LEEAGFGYIILKVDPLIGAKTEFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDKVVEQVDAGKsgsDIELPHILAKPEVCVERAGFENPYAKAKALASLFMAEKVAQINFPACFMMKELEDVALTTATGHEMMRAAAELAVQAREIEKINDTVSRHPHSKKGKVLSKTRLFEKP-a...
H1YWR8_9EURY/2-280             .VVKVGIAKLGNIGSGVMAELLLDERADREDMQTFMATSGTKLQPEDID...RVVDNMK-AW..GPDFCIVVSPNGVLPGPKGAREALAAAGIPCVVITD.DITSK.K.D..DfaA...LKESNFGYIIMKADSMIGARREFLDPVEMSDYNGNLIKVLTITGAFRKLQLALDAVIDQVKAGKkgaELELPKIVMTSDKAV-ADEFTNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGHENYTPIVASAHEMMRSATLLCDEAREIEKGCDGVIRMPHKNDGEIVKKTALISKP-w...
#=GC SS_cons                   .-EEEEEEEES--HHHHHTTGGGSTTS--SSEEEEEEEEET--SHHHHHHHHHHHHHHHHHH..--SEEEEE-S-TTSHHHHHHHHHHHHSSS-EEEEEE.GGGGG.G.H..H..H...HHHTT-EEEEETTS------TTT--HHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTT--.-GGGS-EEEESGGGGGGSS--SSHHHHHHHHHHHHHHHHHHHHHHHHHHT---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT---B--B-TTSSB--BSSTTS---....
#=GC seq_cons                  .VVKIGIlKhGNIGhSsllDLlLDERADRpDIsVRVlGSGAKMsPEplE...cssschlp-h..cPDFlIhISPNsusPGPppARElLtttslPsllIuD.uPuhK.s.K..D..t...hccpGhGYIIlKsDPMIGARREFLDPsEMAhFNuDllKVLAsTGAlRlVQptlDcsIcslctGK...-lcLP+IVlos-KAVEtupFsNPYAKAKAhAAaphAEKVAslDVKGCFMsK-hEcYIPlVASAHEhhRhAAcLsDEARElEKusDuVhRpPHupcGclLsKscLhpKPE....
//
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