GenomeNet

Database: Pfam
Entry: McyA_C
LinkDB: McyA_C
Original site: McyA_C 
#=GF ID   McyA_C
#=GF AC   PF12593.3
#=GF DE   Microcystin synthetase C terminal
#=GF AU   Gavin OL
#=GF SE   Prosite
#=GF GA   25.00 25.00;
#=GF TC   53.30 52.40;
#=GF NC   17.40 16.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18375794
#=GF RT   Natural occurrence of microcystin synthetase deletion mutants
#=GF RT   capable of producing microcystins in strains of the genus
#=GF RT   Anabaena (Cyanobacteria).
#=GF RA   Fewer DP, Tooming-Klunderud A, Jokela J, Wahlsten M, Rouhiainen
#=GF RA   L, Kristensen T, Rohrlack T, Jakobsen KS, Sivonen K;
#=GF RL   Microbiology. 2008;154:1007-1014.
#=GF DR   INTERPRO; IPR022583;
#=GF CC   This domain family is found in bacteria, and is approximately 40
#=GF CC   amino acids in length. The family is found in association with
#=GF CC   Pfam:PF08242, Pfam:PF00501. There is a conserved YAN sequence
#=GF CC   motif. Microcystins form a large family of small cyclic
#=GF CC   heptapeptides harbouring extensive modifications in amino acid
#=GF CC   residue composition and functional group chemistry. These
#=GF CC   peptide hepatotoxins contain a range of non-proteinogenic amino
#=GF CC   acids and unusual peptide bonds, and are typically N-methylated.
#=GF CC   They are synthesized on large enzyme complexes consisting of
#=GF CC   non-ribosomal peptide synthetases and polyketide synthases. This
#=GF CC   family is made up of the C terminal of microcystin synthetase,
#=GF CC   one of the proteins involved in this synthesis pathway.
#=GF SQ   77
#=GS Q9RGC7_MICAE/396-434    AC Q9RGC7.1
#=GS Q9RGD0_MICAE/396-434    AC Q9RGD0.1
#=GS Q9RAK2_9CHRO/396-434    AC Q9RAK2.1
#=GS Q50J25_OSCAG/783-821    AC Q50J25.1
#=GS B4XTZ8_ANAFL/443-485    AC B4XTZ8.1
#=GS B4XTZ4_9NOST/443-485    AC B4XTZ4.1
#=GS Q1W5R7_MICAE/399-437    AC Q1W5R7.2
#=GS Q9RAK0_9CHRO/396-434    AC Q9RAK0.1
#=GS B9VVD8_9NOST/410-452    AC B9VVD8.1
#=GS Q50J24_OSCAG/783-821    AC Q50J24.1
#=GS Q6BE86_MICAE/381-414    AC Q6BE86.1
#=GS A9P5D2_9CHRO/438-476    AC A9P5D2.1
#=GS Q9R2U1_MICAE/396-434    AC Q9R2U1.1
#=GS B4XU01_9NOST/443-485    AC B4XU01.1
#=GS A8YJV7_MICAE/1081-1119  AC A8YJV7.1
#=GS Q8G983_OSCAG/1091-1129  AC Q8G983.1
#=GS Q9RGC6_MICAE/396-434    AC Q9RGC6.1
#=GS Q6BE83_MICVR/381-414    AC Q6BE83.1
#=GS A9P5C8_9CHRO/438-476    AC A9P5C8.1
#=GS A9P5C9_MICVR/438-476    AC A9P5C9.1
#=GS D8L7C8_9CYAN/728-766    AC D8L7C8.1
#=GS A9P5D0_MICAE/438-476    AC A9P5D0.1
#=GS Q6BE87_MICAE/381-414    AC Q6BE87.1
#=GS Q6BE78_9CHRO/381-414    AC Q6BE78.1
#=GS Q9R3V3_MICAE/396-434    AC Q9R3V3.1
#=GS B4XU05_ANAFL/443-485    AC B4XU05.1
#=GS Q50J22_OSCAG/783-821    AC Q50J22.1
#=GS A8WEM0_MICAE/406-444    AC A8WEM0.1
#=GS H6VNP5_MICVR/389-425    AC H6VNP5.1
#=GS A9P5D1_9CHRO/438-476    AC A9P5D1.1
#=GS B4XU02_9NOST/443-485    AC B4XU02.1
#=GS Q9RAK1_9CHRO/396-434    AC Q9RAK1.1
#=GS D2KHT4_MICAE/398-436    AC D2KHT4.1
#=GS Q50J23_PLARU/783-821    AC Q50J23.1
#=GS B4XTZ6_9NOST/443-485    AC B4XTZ6.1
#=GS Q9RGC9_MICAE/396-434    AC Q9RGC9.1
#=GS H6VNP2_MICAE/387-420    AC H6VNP2.1
#=GS H6VNP4_MICAE/388-425    AC H6VNP4.1
#=GS Q6BE79_MICAE/381-414    AC Q6BE79.1
#=GS Q50J16_OSCAG/783-821    AC Q50J16.1
#=GS A9P5C5_MICAE/438-476    AC A9P5C5.1
#=GS Q6BE81_MICVR/381-414    AC Q6BE81.1
#=GS B4XU03_ANAFL/443-485    AC B4XU03.1
#=GS Q50J18_PLARU/783-821    AC Q50J18.1
#=GS B4XU00_9NOST/443-485    AC B4XU00.1
#=GS B4XTZ3_9NOST/443-485    AC B4XTZ3.1
#=GS Q9S1A9_MICAE/1081-1119  AC Q9S1A9.1
#=GS Q9R2V6_MICAE/396-434    AC Q9R2V6.1
#=GS Q6BE80_MICAE/381-414    AC Q6BE80.1
#=GS Q9RAK3_9CHRO/396-434    AC Q9RAK3.1
#=GS Q3LS67_9CHRO/395-433    AC Q3LS67.1
#=GS Q9RGC8_MICAE/396-434    AC Q9RGC8.1
#=GS A9P5C6_MICAE/438-476    AC A9P5C6.1
#=GS A9P5C7_9CHRO/438-476    AC A9P5C7.1
#=GS B4XTZ2_9NOST/443-485    AC B4XTZ2.1
#=GS B4XTZ1_9NOST/443-485    AC B4XTZ1.1
#=GS Q6BE82_9CHRO/381-414    AC Q6BE82.1
#=GS Q6BE85_MICAE/381-414    AC Q6BE85.1
#=GS Q50J27_PLARU/783-821    AC Q50J27.1
#=GS D8L7D0_9CYAN/767-805    AC D8L7D0.1
#=GS B4XU04_ANAFL/443-485    AC B4XU04.1
#=GS H6VNP3_MICAE/387-420    AC H6VNP3.1
#=GS Q50J17_PLARU/783-821    AC Q50J17.1
#=GS D8L7D1_9CYAN/720-758    AC D8L7D1.1
#=GS B4XTZ7_9NOST/443-485    AC B4XTZ7.1
#=GS B4XTZ5_9NOST/443-485    AC B4XTZ5.1
#=GS B4XU06_9NOST/443-485    AC B4XU06.1
#=GS Q8RTG5_MICAE/1089-1127  AC Q8RTG5.1
#=GS Q9RAK4_9CHRO/396-434    AC Q9RAK4.1
#=GS Q50J26_OSCAG/783-821    AC Q50J26.1
#=GS B4XTZ9_9NOST/443-485    AC B4XTZ9.1
#=GS D8L7C9_OSCAG/692-730    AC D8L7C9.1
#=GS Q9RNB1_MICAE/1081-1119  AC Q9RNB1.1
#=GS Q7WRX9_9NOST/1078-1120  AC Q7WRX9.1
#=GS B9U3K0_9NOSO/454-491    AC B9U3K0.1
#=GS Q6BE77_9CHRO/381-414    AC Q6BE77.1
#=GS B0JPV5_MICAN/1081-1119  AC B0JPV5.1
Q9RGC7_MICAE/396-434               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q9RGD0_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
Q9RAK2_9CHRO/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q50J25_OSCAG/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XTZ8_ANAFL/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B4XTZ4_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q1W5R7_MICAE/399-437               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q9RAK0_9CHRO/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
B9VVD8_9NOST/410-452               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q50J24_OSCAG/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
Q6BE86_MICAE/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
A9P5D2_9CHRO/438-476               DVIFAPLENS-..RRNYIAFTPTH.TVKP..EWQLYANHPLRSKL
Q9R2U1_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
B4XU01_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
A8YJV7_MICAE/1081-1119             DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
Q8G983_OSCAG/1091-1129             DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
Q9RGC6_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q6BE83_MICVR/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
A9P5C8_9CHRO/438-476               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
A9P5C9_MICVR/438-476               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
D8L7C8_9CYAN/728-766               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
A9P5D0_MICAE/438-476               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q6BE87_MICAE/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
Q6BE78_9CHRO/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
Q9R3V3_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
B4XU05_ANAFL/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q50J22_OSCAG/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
A8WEM0_MICAE/406-444               DVIFAPLENS-..QRNYIAFTPTQ.TAKP..EWQLYANHPLRSKL
H6VNP5_MICVR/389-425               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRS--
A9P5D1_9CHRO/438-476               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
B4XU02_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q9RAK1_9CHRO/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
D2KHT4_MICAE/398-436               DVIFTSLENS-..RRNYIAFTPTD.TAKP..EWQLYANHPLRSKL
Q50J23_PLARU/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XTZ6_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q9RGC9_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
H6VNP2_MICAE/387-420               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHP-----
H6VNP4_MICAE/388-425               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSK-
Q6BE79_MICAE/381-414               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHP-----
Q50J16_OSCAG/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
A9P5C5_MICAE/438-476               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q6BE81_MICVR/381-414               DVIFATLENS-..QRNYIAFTPTH.TAKP..EGQLYANHP-----
B4XU03_ANAFL/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q50J18_PLARU/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XU00_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B4XTZ3_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q9S1A9_MICAE/1081-1119             DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q9R2V6_MICAE/396-434               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EGQLYANHPLRSKL
Q6BE80_MICAE/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
Q9RAK3_9CHRO/396-434               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q3LS67_9CHRO/395-433               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
Q9RGC8_MICAE/396-434               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
A9P5C6_MICAE/438-476               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
A9P5C7_9CHRO/438-476               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
B4XTZ2_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B4XTZ1_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q6BE82_9CHRO/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
Q6BE85_MICAE/381-414               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHP-----
Q50J27_PLARU/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
D8L7D0_9CYAN/767-805               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XU04_ANAFL/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
H6VNP3_MICAE/387-420               DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHP-----
Q50J17_PLARU/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
D8L7D1_9CYAN/720-758               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XTZ7_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B4XTZ5_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B4XU06_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
Q8RTG5_MICAE/1089-1127             DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
Q9RAK4_9CHRO/396-434               DVIFAPLENS-..RRNYIAFTPTH.TAKP..EGQLYANHPLRSKL
Q50J26_OSCAG/783-821               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
B4XTZ9_9NOST/443-485               DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
D8L7C9_OSCAG/692-730               DAIFVKEQRRKphRAKLTNLSKTH.Q---..DWQQYANHPLQPQL
Q9RNB1_MICAE/1081-1119             DVIFAPLENS-..QRNYIAFTPTH.TVKP..EGQLYANHPLRSKL
Q7WRX9_9NOST/1078-1120             DVIFVQHQSQA..KVPLRVFTPTNgQAKPlhDWQFYANQPLQPRL
B9U3K0_9NOSO/454-491               DVIFGQRQSQG..QIPLRVFTATQ.QR--..DWRLYANQPLQPKL
Q6BE77_9CHRO/381-414               DVIFAPLENS-..QRNYIAFTPTH.TAKP..EWQLYANHP-----
B0JPV5_MICAN/1081-1119             DVIFAPLENS-..RRNYIAFTPTH.TAKP..EWQLYANHPLRSKL
#=GC seq_cons                      DVIFs.hpsp...+tshhsFTPTH.pAKP..-WQhYANHPLps+L
//
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