GenomeNet

Database: Pfam
Entry: Med2
LinkDB: Med2
Original site: Med2 
#=GF ID   Med2
#=GF AC   PF11214.6
#=GF DE   Mediator complex subunit 2
#=GF AU   Wood V, Coggill P
#=GF SE   Wood V
#=GF GA   21.50 21.50;
#=GF TC   21.90 24.10;
#=GF NC   21.30 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   14988503
#=GF RT   Site-specific Srb10-dependent phosphorylation of the yeast
#=GF RT   Mediator subunit Med2 regulates gene expression from the
#=GF RT   2-microm plasmid. 
#=GF RA   Hallberg M, Polozkov GV, Hu GZ, Beve J, Gustafsson CM, Ronne H,
#=GF RA   Bjorklund S; 
#=GF RL   Proc Natl Acad Sci U S A. 2004;101:3370-3375.
#=GF DR   INTERPRO; IPR021017;
#=GF CC   This family of mediator complex subunit 2 proteins is conserved
#=GF CC   in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with
#=GF CC   and phosphorylates Med2. Post-translational modifications of
#=GF CC   Mediator subunits are important for regulation of gene
#=GF CC   expression [2].
#=GF SQ   56
#=GS A0A0A8LD02_9SACH/10-111  AC A0A0A8LD02.1
#=GS A3GIB2_PICST/2-106       AC A3GIB2.2
#=GS W9Y4X5_9EURO/30-104      AC W9Y4X5.1
#=GS G0W4Z7_NAUDC/46-150      AC G0W4Z7.1
#=GS A0A072P0S2_9EURO/28-101  AC A0A072P0S2.1
#=GS Q5A121_CANAL/4-106       AC Q5A121.1
#=GS G8ZTP8_TORDC/21-149      AC G8ZTP8.1
#=GS Q59MI1_CANAL/4-111       AC Q59MI1.1
#=GS Q5AJW7_CANAL/4-113       AC Q5AJW7.1
#=GS K0KU99_WICCF/3-101       AC K0KU99.1
#=GS C4Y5P3_CLAL4/2-104       AC C4Y5P3.1
#=GS Q5A0G8_CANAL/4-106       AC Q5A0G8.1
#=GS G8BNM5_TETPH/27-128      AC G8BNM5.1
#=GS J8Q3R0_SACAR/27-124      AC J8Q3R0.1
#=GS A0A0L0NYU4_9ASCO/2-105   AC A0A0L0NYU4.1
#=GS W2S8R1_9EURO/32-102      AC W2S8R1.1
#=GS W9XMT2_9EURO/13-83       AC W9XMT2.1
#=GS MED2_KLULA/10-161        AC Q6CJZ6.1
#=GS W9VSH8_9EURO/26-100      AC W9VSH8.1
#=GS Q59JS9_CANAL/78-181      AC Q59JS9.1
#=GS H2AWU3_KAZAF/30-168      AC H2AWU3.1
#=GS G8BEJ8_CANPC/4-106       AC G8BEJ8.1
#=GS M3K369_CANMX/4-107       AC M3K369.1
#=GS A7TIL6_VANPO/13-117      AC A7TIL6.1
#=GS Q5A7J9_CANAL/4-113       AC Q5A7J9.1
#=GS A5E6L9_LODEL/4-107       AC A5E6L9.1
#=GS J4TZU1_SACK1/27-124      AC J4TZU1.1
#=GS S6E1X7_ZYGB2/19-119      AC S6E1X7.1
#=GS Q59L80_CANAL/4-111       AC Q59L80.1
#=GS J7S3C1_KAZNA/2-106       AC J7S3C1.1
#=GS I6NDA8_ERECY/11-110      AC I6NDA8.1
#=GS G8XZW6_PICSO/2-167       AC G8XZW6.1
#=GS G8Y2V7_PICSO/2-167       AC G8Y2V7.1
#=GS Q5AB61_CANAL/4-106       AC Q5AB61.1
#=GS Q59L38_CANAL/4-106       AC Q59L38.1
#=GS E7NGM2_YEASO/27-126      AC E7NGM2.1
#=GS Q59JZ4_CANAL/4-119       AC Q59JZ4.1
#=GS Q59KS8_CANAL/4-107       AC Q59KS8.1
#=GS C5DNG0_LACTC/36-139      AC C5DNG0.1
#=GS W9WEP5_9EURO/27-100      AC W9WEP5.1
#=GS G3AIB7_SPAPN/5-109       AC G3AIB7.1
#=GS C5DPL2_ZYGRC/19-161      AC C5DPL2.1
#=GS H6BL10_EXODN/27-103      AC H6BL10.1
#=GS A5DR23_PICGU/2-106       AC A5DR23.2
#=GS Q5ACG3_CANAL/4-106       AC Q5ACG3.1
#=GS MED2_YEAST/27-126        AC Q12124.1
#=GS Q6BXX9_DEBHA/2-106       AC Q6BXX9.2
#=GS MED2_ASHGO/20-119        AC Q757M0.1
#=GS Q5AAE6_CANAL/4-106       AC Q5AAE6.1
#=GS C5MIA5_CANTT/4-106       AC C5MIA5.1
#=GS G0V7X6_NAUCC/13-112      AC G0V7X6.1
#=GS I2H5C7_TETBL/22-121      AC I2H5C7.1
#=GS MED2_CANGA/2-160         AC Q6FWM4.1
#=GS Q59K56_CANAL/4-150       AC Q59K56.1
#=GS I2JYQ1_DEKBR/1-105       AC I2JYQ1.2
#=GS Q59L99_CANAL/4-106       AC Q59L99.1
A0A0A8LD02_9SACH/10-111             ............r-QENRLTQCFDDILRLSADLLTQQQLK.TIKLDPKVTTGYSKSQ.....QKGLADRLSQFYSLIDTLDVSLQTTADYVDAVKDNASQLKKQREEE....QIKKQEQ..EK--lekq...........................................................
A3GIB2_PICST/2-106                  .............NLQTKLDNSLNDILKTSGYIF--EIIN.NNRKQSNLITGTNNQLitpaiTSQLASNITRFDDILDETLSKLNDTRWCLDQIMENKQKQEEMKLKE....ELERQKKlkEE--ee.............................................................
W9Y4X5_9EURO/30-104                 .......kdplny---------------------------.------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLALNKARREAKAREd..sAAHAKRK..HEE-ikdeqek........................................................
G0W4Z7_NAUDC/46-150                 ............r-KTNKLTQCFDDILKLSTEMMVQQQLK.TIQLDSNLINGFNENQ.....QNSLKEKINSFHGILDDLEISINKSLTYLDTISKISIEKRKENIKTkilkEQEEKEK..E---kqle...........................................................
A0A072P0S2_9EURO/28-101             .....vlkdplny---------------------------.------------AQST.....KAVLAETAKKFQDALDDCEIQILDVKWYLERQLTLNKERREAKARE....DSA----..----aavsakrklddik..................................................
Q5A121_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAVRKKR..EEE-a..............................................................
G8ZTP8_TORDC/21-149                 ............a-HRNRLTECFDDIMKVAAEMMVQQQLK.TVQLDSAVVNGFSQAQ.....QRVLSEKIHMFHAILDDLQTTLTKSKSYVGTIHEIALEKQKVKEKE....RADLRKR..QEEEeqrknkeqeekarreemekkadgqrqqqs..................................
Q59MI1_CANAL/4-111                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gakkkaee.......................................................
Q5AJW7_CANAL/4-113                  .............NLQTRLHNSLDEILKSSGYIL--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKC..EEE-akkkaeea.......................................................
K0KU99_WICCF/3-101                  ..........nqi---DNLSLSFNEILLNVGTLF-DE-LV.SD-KTTNLVLPNNNKK.....SNKLNDSIKQFDKNLDDILIQLNDISLFDRKLKQTKLEKEQAKLNN....NNTTDTQ..EK--qiep...........................................................
C4Y5P3_CLAL4/2-104                  .............NLEAKLTSTLNDVLRSSGYIF--EIIN.NNKKQSNIVTGPNNQLipsqvTNQLAQSIAQFDQILDDTVSKFNDARWCIEQMVDSRQKQEEMKHQE....EIERQRR..EEA-d..............................................................
Q5A0G8_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gak............................................................
G8BNM5_TETPH/27-128                 ............k-YRNKVTQCFDDILDVSTQMLVQQQLK.TIQLDINVTNGFNLSQ.....QKILHEKVNLFHSLLDDLECTLETSKTFTEHIAKLGKQREEEKLKK....DKEREEE..----lertrk.........................................................
J8Q3R0_SACAR/27-124                 ............t-YKNKLTVCFDDILKVGAEMMMQQQLK.NVQLDSYLVNGFSQPQ.....QRLLKEKVKLFHGILDDLETSLSQSSSYVETLTVLGEERE--KERQ....EAERKKA..EEE-n..............................................................
A0A0L0NYU4_9ASCO/2-105              .............NLETRLTGTLNDVLRTSGYIF--EIIN.NNKRQSNLITGPNNQLipppiTAQLAASVAQFDLILDDTVSKFNDARWCVEQIVENKQKQEELRIQE....EIERKKR..LEE-qr.............................................................
W2S8R1_9EURO/32-102                 .....gnfgqstk---------------------------.----------------.....-GIIQECSKQFQDALDDCEIQILDAKWYLEHQLRLRKQKRAEEAKA....REEQA--..----asakrkhdqvead..................................................
W9XMT2_9EURO/13-83                  ......ikdplny---------------------------.------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLALNKARREAEAREe..sAAHAKRK..HE--eik............................................................
MED2_KLULA/10-161                   ............r-QENKLTQYFDDILRLSADLLTQQQLK.TIKLDPKVTTGFSKAQ.....QKGLGDRITQFYSLLDTLDVSLQTTADYVGAVKDSALQLKKQREEE....QIKKQEQ..EK--lerqlleqqkleqqqleqkqlkqkqqqqqqqqqqqqqqqpqeqqheqqqrysak.........
W9VSH8_9EURO/26-100                 ayvmkdpvnfapa---------------------------.---------------T.....KAVLAETAKKFHDALDDCEIQILNAKWYLERQLAANRARREAKARDd.saS-SAKRK..R---devqd..........................................................
Q59JS9_CANAL/78-181                 .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKR..EEE-ak.............................................................
H2AWU3_KAZAF/30-168                 ............y-ERNRLTSCLDDILKLSSEMIVQEQLK.TIQLSNSIVSGFNINQ.....QRQLKDKIHTFHSILDDIDITLANTSNYIVQLTEIGTERQIQIKQE....EEVLRRK..KQ--lqqeeelrrkkqleeeelkkkkqleaddelkrkkiqeqede......................
G8BEJ8_CANPC/4-106                  .............NLQTKLENSLYEVLKTAGFIF--EVIN.NNKKQSALITGPNNQLiqptiIKQLTNHINEFDSILDETIFKFNDAKWCIDTMIENKQRQEEMKIKE....ELERQKR..EAE-a..............................................................
M3K369_CANMX/4-107                  .............NLQTKLDDTLNEILKTSGYIF--EIVN.NNKRQSNLITGPNNQPippyvIQKLNGQISKFDEILDETVSKFNDAKWCVATMVENKQKQEELKARE....ELERQRR..EAE-ak.............................................................
A7TIL6_VANPO/13-117                 ...........gg--KNKLVECFEDILEVSSQMLVQQQLK.SIQLDNSVISGFNQGQ.....QKVLLEKVTLFHSILDDLEITLNKGKNYVDELTKIGKDKEEERERVr.raEEEKKRL.lEEE-ek.............................................................
Q5A7J9_CANAL/4-113                  .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EEAKKKE..EEA-kkkeeeak.......................................................
A5E6L9_LODEL/4-107                  .............NLQTKLDSAFNDILRTAGFIF--EIIN.NNEKQNRLITGPNNQLiqptiIQQLTNHINKFDDILDETVFKFNDAKWCIDTMIENKQKQQEMKIKE....ELERQRR..EAEEa..............................................................
J4TZU1_SACK1/27-124                 ............t-YKNKLTVCFDDILKVGAEMMMQQQSK.NVQLDSYLVNGFSHSQ.....QRLLKEKVKLFHGILDDLETSLNQSSSYVNTLTMLGKEK--EKERE....EAERRRA..EEE-n..............................................................
S6E1X7_ZYGB2/19-119                 ............v-HKNKLTQCFDDIMRVAAEMMLHQQLK.TVQLDCSVVNGFSYNQ.....QRVLGEKIHVFHAILDDMETTLDKSKSYVEAVYETGREKEIKKERE....REELRRR..QEEEe..............................................................
Q59L80_CANAL/4-111                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..EEA-kkkeee.........................................................
J7S3C1_KAZNA/2-106                  ............t-EQNKLTRCFDDILRLSSEMLVQQQLK.TIQLDT--VNGFTQDH.....QKVLSEKIHSFHGILDEVDVTLLNAVRFVEKFDAVSKEKELERVKQ...rEREAQIT..AEEEarkkre.........................................................
I6NDA8_ERECY/11-110                 ............m-NTDRLTQCLDDIMRAATEMMVQQQLK.TIQLNSDVAAGFRKNF.....SKSLGDKVRLFHSILDGVDTTLTTASQYLETVDDVAHRMKQWKLRQ....EEELRRK..QQEE...............................................................
G8XZW6_PICSO/2-167                  .............NLEEKLNDTLNEILKTSGYVF--EIIS.SNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-EELKIRM....EEEKQKKirEQE-ekrrqdeelarkrreqeeernrierekdekmkeeamkrekeleekrkaeqereserqreqkaa
G8Y2V7_PICSO/2-167                  .............NLEEKLNDTLNDILKTSGYVF--EIIN.SNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-EELKIRM....EEEKQKKirEQE-ekkrqdeelarkrreqeeernrierekdekmkeeamkrekeleqkrkaeqerelerqreqkaa
Q5AB61_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EEARKKR..EEE-a..............................................................
Q59L38_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSPNGEIQNFHAILDQTVSKLNDAEWRLGVMVEKKKKLDELKVKE....EAARKKE..EEA-k..............................................................
E7NGM2_YEASO/27-126                 ............t-YKNKLTVCFDDILKVGAEMMMQQQLK.NVQLDSYLVNGFSQSQ.....QKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKE--KERE....EAEKKRA..EQE-nmr............................................................
Q59JZ4_CANAL/4-119                  .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAAKKKE..EEA-kkaeqakkaeeakk.................................................
Q59KS8_CANAL/4-107                  .............NLQTRLHNSLDEILKSSGYIF--EVID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKR..EEE-ak.............................................................
C5DNG0_LACTC/36-139                 ............v-HQSRLTQCFDEIMKTAAEMLVQQQIK.SIQLSSDIAPGYTQKQ.....YKSLGDKVHAFHSVLDDLDLTLSASKSCVDKLALEAQERKQEAEKQrikeEEEARKK..----lsev...........................................................
W9WEP5_9EURO/27-100                 ....yamkdplny---------------------------.------------AQST.....KAVLAETAKKFQDALDDCEVQILDAKWYLERQLALNKARREAKAREd.saASAKRKR..EE--pkd............................................................
G3AIB7_SPAPN/5-109                  .............NLQTKLDASLNDILKTSGYIF--EVLN.NNKKQSNLLTGPNNQLitpqiIAQLSHQMLKFDDILDETITKFNDARWCIDQMVENKQRQEEMKIRE....EQERARRlkEE--ee.............................................................
C5DPL2_ZYGRC/19-161                 ............l-HENKLTQCFDDIMRVAVEMMLHQQLK.TVQLDSSVVNGFSHNQ.....QRMLSEKIHIFHAILDDMETTLGKSKDYVEAIYELGREKELQKERE....REELRRR..QEEEerkskeqeelrrhqemelkaqqekeqqqqeqqeqqkqqkqdnd....................
H6BL10_EXODN/27-103                 ...ayaikdpany---------------------------.------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLAVNKARREEKARQesaaAHAKRKR..E---etted..........................................................
A5DR23_PICGU/2-106                  .............NLEEKLRSSLDDVLCTSGYIF--EIIG.NNRKQSNLLTGTNNSLitpavTNSLARSLAKFDEVLDDTISKFNDTRWCVEQIVENKQRQKEQKARE....EEERKRL..DDE-krk............................................................
Q5ACG3_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKFEELKVIE....AAARKKR..EEE-a..............................................................
MED2_YEAST/27-126                   ............t-YKNKLTVCFDDILKVGAEMMMQQQLK.NVQLDSYLVNGFSQSQ.....QKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKE--KERE....EAEKKRA..EQE-nmr............................................................
Q6BXX9_DEBHA/2-106                  .............NLEEKLNNSLNDILKSSGYIF--EIIH.SRKKQSNLITGTNNQLitpviTSQLTNSITKFEDILDDTICKFNDTKWCVEQMLQNRQKQEELKLKE....EEEKQRR..IKE-dde............................................................
MED2_ASHGO/20-119                   ...........mr--GDRLTQCLDDIMRASTEMMVQQQLK.TIQLNSDVAAGFRKAL.....SKSLGDRVRAFHSILDGVETTLTTASQYLDAVEEAAVKMKQWKQQQ....EEEQRRK..HQAE...............................................................
Q5AAE6_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKFDELKVKE....EEARKKR..EEE-a..............................................................
C5MIA5_CANTT/4-106                  .............NLQTRLDASLNEILKTSGYIF--EIIN.NNKKQSNLITGPNNQLiqpfvIQQLNNQIGKFDEILDETVSKFNDAKWCVATMVENKQKQEELKLKE....EMERQKR..EAE-a..............................................................
G0V7X6_NAUCC/13-112                 ...........qp--KNKLTQCFDDILKISSEMLLQQQLK.TIQLDSKVSNGFNASQ.....QRSLKEKINLFHGILDDLEISIAKSFDYVDTIVEISNEKLIKK---....-KELQRK..EEE-aaaaa..........................................................
I2H5C7_TETBL/22-121                 ............v-YKNQLTDCFDDILRLSAEMMVKQQMK.SIQLDASIVNGFNKNQ.....QNILNEKINLFHTILDDLALTIDNSKSYINEIYQIGKEKKIQKEKE....EELRRIQ..EQEE...............................................................
MED2_CANGA/2-160                    ............s-YKNRLTACFDDILKVSAEMMMQQQLK.NVQLDPYMVNGFSAQQ.....QNTLKEKIHMFHGILDDLENMLSKSTYYVDTLANLGKESKRQKELE....LEKQREQ..EEE-ekkqkllelerkkkeqeeeeekkkkqkeeeekrkkeleeqerkkkeqeeeekrrrqqeqd...
Q59K56_CANAL/4-150                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKR..EEE-akkkaeeakkaeeikkaeeakkveeakkaeeakkaeeakkaeeak..................
I2JYQ1_DEKBR/1-105                  ...........mt---NLLKDSMDNIFISSADILDKLTYKlSSATTSTVIPHNNDSLlk.plTDVLKXDFEAYNRVLDNYNLELLGAESMLTYMKVKMKKEAELQQKM....ETERVKK..EKEEa..............................................................
Q59L99_CANAL/4-106                  .............NLQTRLHNSLDEILKSSGYIF--EIID.QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKR..EEE-a..............................................................
#=GC seq_cons                       ..............hps+LpsshD-IL+sSu.hh..p.lc.ssphpSsllsu.Npph.....ppsLspcIppFHuILD-s.spLs-AcWhlsshl-tp+cp-EhKh+E....Etc++++..Ect.tt.............................................................
//
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