GenomeNet

Database: Pfam
Entry: Med2
LinkDB: Med2
Original site: Med2 
#=GF ID   Med2
#=GF AC   PF11214.5
#=GF DE   Mediator complex subunit 2
#=GF AU   Wood V, Coggill P
#=GF SE   Wood V
#=GF GA   21.50 21.50;
#=GF TC   22.20 31.10;
#=GF NC   21.30 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   14988503
#=GF RT   Site-specific Srb10-dependent phosphorylation of the yeast
#=GF RT   Mediator subunit Med2 regulates gene expression from the
#=GF RT   2-microm plasmid. 
#=GF RA   Hallberg M, Polozkov GV, Hu GZ, Beve J, Gustafsson CM, Ronne H,
#=GF RA   Bjorklund S; 
#=GF RL   Proc Natl Acad Sci U S A. 2004;101:3370-3375.
#=GF DR   INTERPRO; IPR021017;
#=GF CC   This family of mediator complex subunit 2 proteins is conserved
#=GF CC   in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with
#=GF CC   and phosphorylates Med2. Post-translational modifications of
#=GF CC   Mediator subunits are important for regulation of gene
#=GF CC   expression [2].
#=GF SQ   54
#=GS C4YNA4_CANAW/4-111   AC C4YNA4.1
#=GS A3GIB2_PICST/2-106   AC A3GIB2.2
#=GS C4YFX4_CANAW/4-119   AC C4YFX4.1
#=GS G0W4Z7_NAUDC/46-150  AC G0W4Z7.1
#=GS Q5A121_CANAL/4-106   AC Q5A121.1
#=GS G8ZTP8_TORDC/21-149  AC G8ZTP8.1
#=GS Q59MI1_CANAL/4-111   AC Q59MI1.1
#=GS C4YI74_CANAW/4-106   AC C4YI74.1
#=GS Q5AJW7_CANAL/4-113   AC Q5AJW7.1
#=GS K0KU99_WICCF/3-101   AC K0KU99.1
#=GS C4Y5P3_CLAL4/2-104   AC C4Y5P3.1
#=GS Q5A0G8_CANAL/4-106   AC Q5A0G8.1
#=GS G8BNM5_TETPH/27-128  AC G8BNM5.1
#=GS C4YGC9_CANAW/4-109   AC C4YGC9.1
#=GS J8Q3R0_SACAR/27-124  AC J8Q3R0.1
#=GS MED2_KLULA/10-161    AC Q6CJZ6.1
#=GS Q59JS9_CANAL/78-181  AC Q59JS9.1
#=GS H2AWU3_KAZAF/30-168  AC H2AWU3.1
#=GS G8BEJ8_CANPC/4-106   AC G8BEJ8.1
#=GS M3K369_CANMX/4-107   AC M3K369.1
#=GS C4YT65_CANAW/4-106   AC C4YT65.1
#=GS C4YFF1_CANAW/4-111   AC C4YFF1.1
#=GS A7TIL6_VANPO/13-117  AC A7TIL6.1
#=GS Q5A7J9_CANAL/4-113   AC Q5A7J9.1
#=GS A5E6L9_LODEL/4-107   AC A5E6L9.1
#=GS J4TZU1_SACK1/27-124  AC J4TZU1.1
#=GS S6E1X7_ZYGB2/19-119  AC S6E1X7.1
#=GS Q59L80_CANAL/4-111   AC Q59L80.1
#=GS J7S3C1_KAZNA/2-106   AC J7S3C1.1
#=GS I6NDA8_ERECY/11-110  AC I6NDA8.1
#=GS G8XZW6_PICSO/2-167   AC G8XZW6.1
#=GS G8Y2V7_PICSO/2-167   AC G8Y2V7.1
#=GS Q5AB61_CANAL/4-106   AC Q5AB61.1
#=GS Q59L38_CANAL/4-106   AC Q59L38.1
#=GS E7NGM2_YEASO/27-126  AC E7NGM2.1
#=GS Q59JZ4_CANAL/4-119   AC Q59JZ4.1
#=GS Q59KS8_CANAL/4-107   AC Q59KS8.1
#=GS C5DNG0_LACTC/36-139  AC C5DNG0.1
#=GS G3AIB7_SPAPN/5-109   AC G3AIB7.1
#=GS C5DPL2_ZYGRC/19-161  AC C5DPL2.1
#=GS H6BL10_EXODN/27-103  AC H6BL10.1
#=GS A5DR23_PICGU/2-106   AC A5DR23.2
#=GS Q5ACG3_CANAL/4-106   AC Q5ACG3.1
#=GS MED2_YEAST/27-126    AC Q12124.1
#=GS Q6BXX9_DEBHA/2-106   AC Q6BXX9.2
#=GS MED2_ASHGO/20-119    AC Q757M0.1
#=GS C4YNA8_CANAW/4-111   AC C4YNA8.1
#=GS Q5AAE6_CANAL/4-106   AC Q5AAE6.1
#=GS C5MIA5_CANTT/4-106   AC C5MIA5.1
#=GS G0V7X6_NAUCC/13-112  AC G0V7X6.1
#=GS I2H5C7_TETBL/22-121  AC I2H5C7.1
#=GS MED2_CANGA/2-160     AC Q6FWM4.1
#=GS Q59K56_CANAL/4-150   AC Q59K56.1
#=GS Q59L99_CANAL/4-106   AC Q59L99.1
C4YNA4_CANAW/4-111              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gakkkeee.......................................................
A3GIB2_PICST/2-106              ..........NLQTKLDNSLNDILKTSGYIF--EIINNNRKQSNLITGTNNQLitpaiTSQLASNITRFDDILDETLSKLNDTRWCLDQIMENKQKQEEMKLKE....ELERQKKlkEE--ee.............................................................
C4YFX4_CANAW/4-119              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..EEA-kkaeqakkaeeakk.................................................
G0W4Z7_NAUDC/46-150             .........r-KTNKLTQCFDDILKLSTEMMVQQQLKTIQLDSNLINGFNENQ.....QNSLKEKINSFHGILDDLEISINKSLTYLDTISKISIEKRKENIKTkilkEQEEKEK..E---kqle...........................................................
Q5A121_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAVRKKR..EEE-a..............................................................
G8ZTP8_TORDC/21-149             .........a-HRNRLTECFDDIMKVAAEMMVQQQLKTVQLDSAVVNGFSQAQ.....QRVLSEKIHMFHAILDDLQTTLTKSKSYVGTIHEIALEKQKVKEKE....RADLRKR..QEEEeqrknkeqeekarreemekkadgqrqqqs..................................
Q59MI1_CANAL/4-111              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gakkkaee.......................................................
C4YI74_CANAW/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVKKKKKHDELKVKE....EAARKKR..EAE-a..............................................................
Q5AJW7_CANAL/4-113              ..........NLQTRLHNSLDEILKSSGYIL--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKC..EEE-akkkaeea.......................................................
K0KU99_WICCF/3-101              .......nqi---DNLSLSFNEILLNVGTLF-DE-LVSD-KTTNLVLPNNNKK.....SNKLNDSIKQFDKNLDDILIQLNDISLFDRKLKQTKLEKEQAKLNN....NNTTDTQ..EK--qiep...........................................................
C4Y5P3_CLAL4/2-104              ..........NLEAKLTSTLNDVLRSSGYIF--EIINNNKKQSNIVTGPNNQLipsqvTNQLAQSIAQFDQILDDTVSKFNDARWCIEQMVDSRQKQEEMKHQE....EIERQRR..EEA-d..............................................................
Q5A0G8_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gak............................................................
G8BNM5_TETPH/27-128             .........k-YRNKVTQCFDDILDVSTQMLVQQQLKTIQLDINVTNGFNLSQ.....QKILHEKVNLFHSLLDDLECTLETSKTFTEHIAKLGKQREEEKLKK....DKEREEE..----lertrk.........................................................
C4YGC9_CANAW/4-109              ..........NLQTRLHNSLDEILKSSGYIF--EIIGHNRKQSNVITSPNNELiqksiTQLLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKIKE....EAAKKKE..EEA-kkae...........................................................
J8Q3R0_SACAR/27-124             .........t-YKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQPQ.....QRLLKEKVKLFHGILDDLETSLSQSSSYVETLTVLGEERE--KERQ....EAERKKA..EEE-n..............................................................
MED2_KLULA/10-161               .........r-QENKLTQYFDDILRLSADLLTQQQLKTIKLDPKVTTGFSKAQ.....QKGLGDRITQFYSLLDTLDVSLQTTADYVGAVKDSALQLKKQREEE....QIKKQEQ..EK--lerqlleqqkleqqqleqkqlkqkqqqqqqqqqqqqqqqpqeqqheqqqrysak.........
Q59JS9_CANAL/78-181             ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKR..EEE-ak.............................................................
H2AWU3_KAZAF/30-168             .........y-ERNRLTSCLDDILKLSSEMIVQEQLKTIQLSNSIVSGFNINQ.....QRQLKDKIHTFHSILDDIDITLANTSNYIVQLTEIGTERQIQIKQE....EEVLRRK..KQ--lqqeeelrrkkqleeeelkkkkqleaddelkrkkiqeqede......................
G8BEJ8_CANPC/4-106              ..........NLQTKLENSLYEVLKTAGFIF--EVINNNKKQSALITGPNNQLiqptiIKQLTNHINEFDSILDETIFKFNDAKWCIDTMIENKQRQEEMKIKE....ELERQKR..EAE-a..............................................................
M3K369_CANMX/4-107              ..........NLQTKLDDTLNEILKTSGYIF--EIVNNNKRQSNLITGPNNQPippyvIQKLNGQISKFDEILDETVSKFNDAKWCVATMVENKQKQEELKARE....ELERQRR..EAE-ak.............................................................
C4YT65_CANAW/4-106              ..........NLQTRLHNSLDEILKSSGYIL--RVIDQNRKQSNVIRSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..E---gak............................................................
C4YFF1_CANAW/4-111              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..EEA-kkkeee.........................................................
A7TIL6_VANPO/13-117             ........gg--KNKLVECFEDILEVSSQMLVQQQLKSIQLDNSVISGFNQGQ.....QKVLLEKVTLFHSILDDLEITLNKGKNYVDELTKIGKDKEEERERVr.raEEEKKRL.lEEE-ek.............................................................
Q5A7J9_CANAL/4-113              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EEAKKKE..EEA-kkkeeeak.......................................................
A5E6L9_LODEL/4-107              ..........NLQTKLDSAFNDILRTAGFIF--EIINNNEKQNRLITGPNNQLiqptiIQQLTNHINKFDDILDETVFKFNDAKWCIDTMIENKQKQQEMKIKE....ELERQRR..EAEEa..............................................................
J4TZU1_SACK1/27-124             .........t-YKNKLTVCFDDILKVGAEMMMQQQSKNVQLDSYLVNGFSHSQ.....QRLLKEKVKLFHGILDDLETSLNQSSSYVNTLTMLGKEK--EKERE....EAERRRA..EEE-n..............................................................
S6E1X7_ZYGB2/19-119             .........v-HKNKLTQCFDDIMRVAAEMMLHQQLKTVQLDCSVVNGFSYNQ.....QRVLGEKIHVFHAILDDMETTLDKSKSYVEAVYETGREKEIKKERE....REELRRR..QEEEe..............................................................
Q59L80_CANAL/4-111              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..EEA-kkkeee.........................................................
J7S3C1_KAZNA/2-106              .........t-EQNKLTRCFDDILRLSSEMLVQQQLKTIQLDT--VNGFTQDH.....QKVLSEKIHSFHGILDEVDVTLLNAVRFVEKFDAVSKEKELERVKQ...rEREAQIT..AEEEarkkre.........................................................
I6NDA8_ERECY/11-110             .........m-NTDRLTQCLDDIMRAATEMMVQQQLKTIQLNSDVAAGFRKNF.....SKSLGDKVRLFHSILDGVDTTLTTASQYLETVDDVAHRMKQWKLRQ....EEELRRK..QQEE...............................................................
G8XZW6_PICSO/2-167              ..........NLEEKLNDTLNEILKTSGYVF--EIISSNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-EELKIRM....EEEKQKKirEQE-ekrrqdeelarkrreqeeernrierekdekmkeeamkrekeleekrkaeqereserqreqkaa
G8Y2V7_PICSO/2-167              ..........NLEEKLNDTLNDILKTSGYVF--EIINSNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-EELKIRM....EEEKQKKirEQE-ekkrqdeelarkrreqeeernrierekdekmkeeamkrekeleqkrkaeqerelerqreqkaa
Q5AB61_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EEARKKR..EEE-a..............................................................
Q59L38_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSPNGEIQNFHAILDQTVSKLNDAEWRLGVMVEKKKKLDELKVKE....EAARKKE..EEA-k..............................................................
E7NGM2_YEASO/27-126             .........t-YKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQ.....QKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKE--KERE....EAEKKRA..EQE-nmr............................................................
Q59JZ4_CANAL/4-119              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAAKKKE..EEA-kkaeqakkaeeakk.................................................
Q59KS8_CANAL/4-107              ..........NLQTRLHNSLDEILKSSGYIF--EVIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKR..EEE-ak.............................................................
C5DNG0_LACTC/36-139             .........v-HQSRLTQCFDEIMKTAAEMLVQQQIKSIQLSSDIAPGYTQKQ.....YKSLGDKVHAFHSVLDDLDLTLSASKSCVDKLALEAQERKQEAEKQrikeEEEARKK..----lsev...........................................................
G3AIB7_SPAPN/5-109              ..........NLQTKLDASLNDILKTSGYIF--EVLNNNKKQSNLLTGPNNQLitpqiIAQLSHQMLKFDDILDETITKFNDARWCIDQMVENKQRQEEMKIRE....EQERARRlkEE--ee.............................................................
C5DPL2_ZYGRC/19-161             .........l-HENKLTQCFDDIMRVAVEMMLHQQLKTVQLDSSVVNGFSHNQ.....QRMLSEKIHIFHAILDDMETTLGKSKDYVEAIYELGREKELQKERE....REELRRR..QEEEerkskeqeelrrhqemelkaqqekeqqqqeqqeqqkqqkqdnd....................
H6BL10_EXODN/27-103             ayaikdpany---------------------------------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLAVNKARREEKARQesaaAHAKRKR..E---etted..........................................................
A5DR23_PICGU/2-106              ..........NLEEKLRSSLDDVLCTSGYIF--EIIGNNRKQSNLLTGTNNSLitpavTNSLARSLAKFDEVLDDTISKFNDTRWCVEQIVENKQRQKEQKARE....EEERKRL..DDE-krk............................................................
Q5ACG3_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKFEELKVIE....AAARKKR..EEE-a..............................................................
MED2_YEAST/27-126               .........t-YKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQ.....QKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKE--KERE....EAEKKRA..EQE-nmr............................................................
Q6BXX9_DEBHA/2-106              ..........NLEEKLNNSLNDILKSSGYIF--EIIHSRKKQSNLITGTNNQLitpviTSQLTNSITKFEDILDDTICKFNDTKWCVEQMLQNRQKQEELKLKE....EEEKQRR..IKE-dde............................................................
MED2_ASHGO/20-119               ........mr--GDRLTQCLDDIMRASTEMMVQQQLKTIQLNSDVAAGFRKAL.....SKSLGDRVRAFHSILDGVETTLTTASQYLDAVEEAAVKMKQWKQQQ....EEEQRRK..HQAE...............................................................
C4YNA8_CANAW/4-111              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKE....EAARKKE..EEA-kkkeee.........................................................
Q5AAE6_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKFDELKVKE....EEARKKR..EEE-a..............................................................
C5MIA5_CANTT/4-106              ..........NLQTRLDASLNEILKTSGYIF--EIINNNKKQSNLITGPNNQLiqpfvIQQLNNQIGKFDEILDETVSKFNDAKWCVATMVENKQKQEELKLKE....EMERQKR..EAE-a..............................................................
G0V7X6_NAUCC/13-112             ........qp--KNKLTQCFDDILKISSEMLLQQQLKTIQLDSKVSNGFNASQ.....QRSLKEKINLFHGILDDLEISIAKSFDYVDTIVEISNEKLIKK---....-KELQRK..EEE-aaaaa..........................................................
I2H5C7_TETBL/22-121             .........v-YKNQLTDCFDDILRLSAEMMVKQQMKSIQLDASIVNGFNKNQ.....QNILNEKINLFHTILDDLALTIDNSKSYINEIYQIGKEKKIQKEKE....EELRRIQ..EQEE...............................................................
MED2_CANGA/2-160                .........s-YKNRLTACFDDILKVSAEMMMQQQLKNVQLDPYMVNGFSAQQ.....QNTLKEKIHMFHGILDDLENMLSKSTYYVDTLANLGKESKRQKELE....LEKQREQ..EEE-ekkqkllelerkkkeqeeeeekkkkqkeeeekrkkeleeqerkkkeqeeeekrrrqqeqd...
Q59K56_CANAL/4-150              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKE....EAARKKR..EEE-akkkaeeakkaeeikkaeeakkveeakkaeeakkaeeakkaeeak..................
Q59L99_CANAL/4-106              ..........NLQTRLHNSLDEILKSSGYIF--EIIDQNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKE....EAARKKR..EEE-a..............................................................
#=GC seq_cons                   ..........NLps+LpsoLD-ILKoSGalh..Ellcps++QSNllTusNNpLI...lppsLsscIppFHuILDpTsoKLNDAcWClsshlEp+++h-EhKl+E....Ett+++c..Ect.tt.............................................................
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