GenomeNet

Database: Pfam
Entry: Med3
LinkDB: Med3
Original site: Med3 
#=GF ID   Med3
#=GF AC   PF11593.6
#=GF DE   Mediator complex subunit 3 fungal
#=GF AU   Coggill P
#=GF SE   manual
#=GF GA   27.60 27.60;
#=GF TC   27.60 27.60;
#=GF NC   27.50 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   10722672
#=GF RT   Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT   polymerase II holoenzyme. 
#=GF RA   Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA   Tzamarias D; 
#=GF RL   J Biol Chem. 2000;275:8397-8403.
#=GF DR   INTERPRO; IPR020998;
#=GF CC   Mediator is a large complex of up to 33 proteins that is
#=GF CC   conserved from plants to fungi to humans - the number and
#=GF CC   representation of individual subunits varying with species. It
#=GF CC   is arranged into four different sections, a core, a head, a tail
#=GF CC   and a kinase-activity part, and the number of subunits within
#=GF CC   each of these is what varies with species. Overall, Mediator
#=GF CC   regulates the transcriptional activity of RNA polymerase II but
#=GF CC   it would appear that each of the four different sections has a
#=GF CC   slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC   physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC   co-repressor [2].
#=GF SQ   29
#=GS J4WEV1_BEAB2/713-874      AC J4WEV1.1
#=GS E7QEW2_YEASZ/37-424       AC E7QEW2.1
#=GS A7TKX4_VANPO/10-396       AC A7TKX4.1
#=GS E7LUG4_YEASV/37-340       AC E7LUG4.1
#=GS G8ZWS1_TORDC/6-322        AC G8ZWS1.1
#=GS S6EL77_ZYGB2/8-332        AC S6EL77.1
#=GS G0WA71_NAUDC/11-385       AC G0WA71.1
#=GS A0A0A8L918_9SACH/8-227    AC A0A0A8L918.1
#=GS E7NHR1_YEASO/37-346       AC E7NHR1.1
#=GS G8JM86_ERECY/6-202        AC G8JM86.1
#=GS C5DHV2_LACTC/14-351       AC C5DHV2.1
#=GS E7KNI8_YEASL/37-432       AC E7KNI8.1
#=GS MED3_CANGA/13-481         AC Q6FXZ4.1
#=GS G8BZH5_TETPH/11-420       AC G8BZH5.1
#=GS B4UMX1_CANGA/13-477       AC B4UMX1.1
#=GS J8LNQ4_SACAR/3-398        AC J8LNQ4.1
#=GS MED3_KLULA/8-228          AC Q6CNQ9.1
#=GS A0A0F8B6X8_CERFI/2-108    AC A0A0F8B6X8.1
#=GS H2AZT1_KAZAF/9-258        AC H2AZT1.1
#=GS E7KCN3_YEASA/37-436       AC E7KCN3.1
#=GS MED3_YEAST/3-397          AC P40356.2
#=GS A0A0A2VVG2_BEABA/147-312  AC A0A0A2VVG2.1
#=GS B4JUB2_DROGR/189-379      AC B4JUB2.1
#=GS MED3_ASHGO/7-167          AC Q752T7.2
#=GS J6EII9_SACK1/3-412        AC J6EII9.1
#=GS I2GX35_TETBL/12-175       AC I2GX35.1
#=GS J7S5W6_KAZNA/5-316        AC J7S5W6.1
#=GS W5LTR6_ASTMX/620-729      AC W5LTR6.1
#=GS C5E049_ZYGRC/9-144        AC C5E049.1
J4WEV1_BEAB2/713-874                 ..............qsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..---ANTKN.lDTSEVPIPT.TIE.....................................ELSPPVr..thRSSSWGPVAATSPSE.EQRSPRNGNSNHD.....--AQSQA...QQQQ....QQQQhQHQ.QQQQ......................-.--YQQ..QQQQQ.....IAQNGdFD..SFD.....SM-SSFP....gDPSAMVMD.PP.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------fpqpllpqdlfalpmtldwnwaemsggaypsvengn.......................
E7QEW2_YEASZ/37-424                  ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
A7TKX4_VANPO/10-396                  ...........................t-ILSGKVKLEQLEDTLGLDDN..........--SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEE--.....QPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKK--YQPLETLyqss..........tgatTTIT.SSANTSNG......PSVTGS....TSAGSAANTPNVS...A..SASTTTKR..AKSNAATPS.SATntpnasgasvgtpnsasagitsgsgitpipttgvsaaSGSAAT.....TAASISATTPTTTTT.TVKKPRKPRQPKK.....---TAAA...NKKQ....PVPS.PLN.SQIP......................LnTASIN..NNNTS.....SAYNN.MK..ANNt..nmKMAPNAGp...mNNQAQMMG.NP.SPK..NMVNTPL.NN.........MMGSLG.G--..VSQDYGMQlqTPN.QP.TPLQMQM...gQQGIQq...qaP----PSQQIPQQFNmg..........nmGNMNNMG-----NM------...-------------....--...----------.--.-----------.-------------------nsmg.......................................................
E7LUG4_YEASV/37-340                  ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRXTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAQQS..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQX.XG.G------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------ts.........................................................
G8ZWS1_TORDC/6-322                   ............................DLLVPDMKLEELETSLATGGD..........-DPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDD--.....LQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSE--KYGTKKFQPLETL..................RIPQ.SN------......----SV....SSPQTQNNAIV--...-..--GANLNK..KANRSNDGT.PVS.....................................QTSTPM.....GSAVPTPY-----AT.TAKKPRKPRQPKK.....PQTPAAA...AAAAa..vAANG.HIK.SQAS......................-.-----..----P.....TPP--.--..--A.....HMVSSVPa...tNPVQ-MVN.SV.PPT..NMMGTPM.QN.........LMSPLG.-NT..PNYGFSQQ..QSQ.QQ.PTPQQQ-....-QRQQ......YNSATKNSTMPQSQP..............MNLNSITPANILSMSMTGDP...----LHQQQQQNK....--...----------.--.-----------.-------------------k..........................................................
S6EL77_ZYGB2/8-332                   ............................DILSINMKLDELELKLASTNG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTSSMQNVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETLksstnl.....gnglasqTQLQ.QQQQQQSQ......AQAQVQ....SQQQSQSQQPQSQ...PqqLPNGNPVS..SSNSI----.--Asrk..............................psksNAGTPG.....SNMNTPSGTTMTNMTpSSKKQRKPRQPKK.....TSS---G...IGMG....PAST.PVM.SASN......................-.-FKAQ..TAQSP....qVGT--.--..---.....KI-AGAP....lNNTTQTVS.SV.PPT..STMNTPM.NN.........VMSPLG.GVApgFGISQSQP..PQS.MP.QQISQQF....S----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------qqlsqqrqqqvqqq.............................................
G0WA71_NAUDC/11-385                  ............................KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--.....MPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTKKFHMLETLkpiv.........epapaTAKA.TKGDASHS......KKKSVA....GTPGSVGNTPVGT...-..TPGSSTGT..VAANVPA--.---.....................................NINANTt...nTSTTSAASTTQTTSS.TAKKPRKPRQNKK.....----AAA...KAQQ....QQQQ.QLL.QQQQ......................-.-----..QQQIPkq.qgIATNP.MM..NMN.....AM-----.....NATP-MMN.SV.SPS..NVMGTPL.NN.........GISPMG.AVM..AGGFYSQP..PGS.QS.QQFDQQM....NNGDH......---NTNNNNF-----..............QNMNNITPANILSMNTVGDP...------QSRMASS....SQ...QYP-------.--.-TNNNNNN---.--TLDLNNLDLSSLNMDFL...........................................................
A0A0A8L918_9SACH/8-227               ...........................a-ILKDNLTFDALRELIIEKES..........--TADDVTDTVVEARKALLPIRVLMNEFVAMIANLES--.....MGNKTSQEKFLAVRMKLIELQNNIQKFSKDFQQLQSLIGTMDQFNNEVNAGEKRFFVEETLgythtvss..gnvtgggkAGNA.LEGNGVAP......SAANAV....AAAS---------...-..----KVVK..KSAIKSNPG.VSAqsnagrrn.....................sakktvisNTGTAGs...vTGNP-TAVTAST---.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------pslkqipntqpmql.............................................
E7NHR1_YEASO/37-346                  ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TATVVS....TNHSTAASTPTTT...A..TPHTNPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQ....FNGS-......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------gkwiqs.....................................................
G8JM86_ERECY/6-202                   ............................EILSAKLTLEELKEKLANNDE..........--SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQIEH--.....LNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSE--SNE-QKFYPLETLn................lLPDP.IKSTASPS......YKKAVNksnaETPSSNAATPSA-...-..----ALSS..NNVVLVGPQ.AKNqrr..............................prtnNKRQPS.....GTASAAPSA------.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------gsagsapis..................................................
C5DHV2_LACTC/14-351                  .....................kefdfgn-----------LHEKLESED-..........-GYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQ--.....ETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSI-KFTPLERLr................hLSDA.SLGNQA-K......SASGGS....PPAAAVASVPTTT...K..QPKSSTNT..PTSNAATPS.ATF.....................................NA----.....---------------.AAKKSRKSRSKKNslptgL--GGHP...VATA....ASPA.AVAaAAAA......................V.STNPG.vAM---.....-GSNP.GI..QQ-.....QFTPS-T.....NPTQ-ILS.SM.SPM..NMMSSP-.MN.........IMSPAN.--N..VNMAYT--..---.--.-------....--GPT......KPPVPSHRHMPSSSQ.............qMNMNGITPANILNMS-----...MMEQANQPHLTTA....PA...PQPPNQ----.-L.DM----NN---.---LDLNNLDLSNLNMDFL...........................................................
E7KNI8_YEASL/37-432                  ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAQQS..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGXE.LDSLDLNNLELGGLNMDFL...........................................................
MED3_CANGA/13-481                    ............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..................ASYN.HRGKA---......GASISN....STPTPAAATPTTA...P..TPGAGTKK..AAKTAPTPT.ATA.....................................TIGTPS.....NNAPTPATTATTPGT.QAKKPRKPRQTKKq..qqAAAAAAA...VAQA....QAQA.QAQ.AQNQnqnnmqnknisnpgmnsnmgtpV.MGNPNmkQMQSP.....IPANA.MN..NMNvphngAMRPSVPngnmgNPSMGNLN.MN.APN..--MGNPN.MNnpnmnnpnaMMSPMAgQGQ..LNQMFPMQ..NHN.QN.GQFMGQQ....SPGPNigqmqfPPNNGNMNGMPGTSDmnlgmnpsmnmnmgMNLNQITPANILSMNTKGKDdqmQNIGMDQNQNQNQ....SQ...NQSQNQNQSM.NM.NMNNDSNNPKSaYDLVDFNSLDLSSLNMDFL...........................................................
G8BZH5_TETPH/11-420                  ......................ffntve-------SLENLEDKLVMNNF..........-ENKDILMEKISSTQKSILPIRLLFNEFIQTMALLNDGKghkteNNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSL--KNNSKQFDPLETLkqidndvfnsqaalatnaADSQ.NNGKTKAK......NSTSTA....ATPNSSVNTPITNlgsQ..TILSNTNA..SVPALATTP.TTV.....................................TKGASVasassKSVTANLSSVNVPAA.TTKKPRKPRQTKK.....STATS-K...KLQS....NSA-.---.----......................-.-ASPM..NPPTPs...nITANK.RA..NKA.....SAQTA--.....QSTGNMLG.MNgSQQ..NVAGNMN.NN.........NNNNMV.--Q..RNNSISMN..SQDfMA.MQYKNGN....GNGNA......PMNNQMMNNQMINNQminnq...mlnqqqMKMNNMGNMNMGNMGNMGNM...NNIN-NMNGMSNM....NN...MNGMNNVNNMgNMaNMNNMNN----.-------------------...........................................................
B4UMX1_CANGA/13-477                  ............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..................ASYN.HRGKA---......GASISN....STPTPAAATPTTA...P..TPGAGTKK..AAKTAPTPT.ATA.....................................TIGTPS.....NNAPTPATTATTPGT.QAKKPRKPRQTKKq..qqAAAAAAA...VAQA....QAQA.QAQ.AQNQnqnnmqnknisnpgmnsnmgtpV.MGNPNmkQMQSP.....IPANA.MN..NMNvphngAMRPSVPngnmgNPSMGNLN.MN.APN..--MGNPN.MNnpnmnnpnaMMSPMAgQGQ..LNQMFPMQ..NHN.QN.GHFMGQQ....SPGPNigqmqfPPNNGNMNGMPGTSDmnlgmnpsmnmnmgMNMNQITPANILSMNTKGKDdqmQNIGMDQNQNQNQ....NQ...N----QNQSM.NM.NMNNDSNNPKSaYDLVDFNSLDLSSLNMDFL...........................................................
J8LNQ4_SACAR/3-398                   ............................SIIPADTKLEDLEVKLAKNEN..........-ETRDNVCKQINEARNEILPLRLQFNEFIQSMANIDHDG.....TKQGDRMVKYLHIRDSILQLNDRFQSLSSHLETLQPLFNTVPEYLRTADNKDRSFQLLEPL..................STYN.QNGTVTGP......AAAVAN....TSHSTAASTPTT-...-..TPHANSNA..HTHSLSNPN.TTTammqqnpma...................gkrgpkgstTIGTP-.....NSAAAAATAA-----.-AKKPRKPRQTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAHPS..AVQTP.....ITA--.--..---.....SMTAALP.....NPTPNIIN.SV.SPT..NVMGTPL.TN.........MMSPMT.---..--NAYSMV..APN.QG.GQPAMSQftnhSNGTN......PNPTTNANNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQQQQ....QP...QQPQQQQYN-.--.-MNTMNNNGKE.LDSLDLNNLELGGLNMDFL...........................................................
MED3_KLULA/8-228                     ...........qifkdnltfdtfrelii-----------------E-KE..........-STADEVADKVLEAKKALLPIRTLMTEFVGMIANLES--.....MGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVNAGEKKFFVQETLg................yTQLA.SNGSAAGI......TKTSSG....NDGNTTGSTANTM...-..AMAKGLKK..NAAGKPN-T.GTGvqsgpgrrns.................tkktghtgpaTAPTTS.....NSAASAAAAAANTPS.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------lkqipntqpmq................................................
A0A0F8B6X8_CERFI/2-108               ........................qeha---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..--------..---------.---.....................................------.....---------------.----------QKK.....EQAQAQA...QAQA....QAQT.QAQ.TQTQ......................V.QV-QA..QTDTPmrdcaIDDDE.YD..EFD.....GMDIEMP.....PPDPLWLT.TN.RSA..SCMST--.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------esdvyidgddysmsyapidysssskshs...............................
H2AZT1_KAZAF/9-258                   ...........................e-VLTLTVKLEELETKFATNEN..........--SKQSVLDLVNETRSLILPIRLQLNEFISLMANIDK--.....MTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYST--KHNSREFKPLESL..................SNDPfAKGSP--R......TTSSGS....ANNTITSATSITT...-..--NANNKI..SAAT-----.PSS.....................................NINTPA.....SS--SQNITNTTP--.SIKKPRKPRQPRK.....------S...ITQT....NTAN.KAS.KT--......................-.-TTPS..-APTP.....VAA-P.MQ..TPG.....TMNPALPv...qN-----FN.TK.TPI..N-LGSPN.GP.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------qfsppp.....................................................
E7KCN3_YEASA/37-436                  ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRPTKK.....AKAQAQA...QAQAqaqaQAQA.QAQ.AQAQ......................V.YAQQS..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
MED3_YEAST/3-397                     ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TATVVS....TNHSAAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP.....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQQQQ....QQ...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
A0A0A2VVG2_BEABA/147-312             ..........aendqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..---ANTKN.lDTSEVPIPT.TIE.....................................ELSPPVr..thRSSSWGPVAATSPSE.EQRSPRNGNPNHD.....--AQSQA...QQQQ....QQQQhQHQ.QQQQ......................-.--YQQ..QQQQQ.....IAQNGdFD..SFD.....SM-SSFP....gDPSAMVMD.PP.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------fpqpllpqdlfalpmtldwnwaemsggaypsvengn.......................
B4JUB2_DROGR/189-379                 yqetypvpdkyydvevlvvaspfpppep---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......TTSTTT....TTTTTTTTTTTTT...T..TPATTTST..STTSTTTPAtTTT.....................................TSTTPA.....TTTTTPATTTTTTST.TPKPSRQRRDTNQt..mhANARLLG...LNLA....AAVQ.QQM.QQNN......................-.NGNN-..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------rsvnkssvalinplgvlrprqllqappppydcvdgniiakdpnntygyfkrrivtktpi
MED3_ASHGO/7-167                     ...........................g-ILRENLTLEELQEWLTSSEG..........--NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQ--.....LSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSETS---ERKFYPKETL..................GTAV.EPVRPLASpsyrrpSNRSSA....DTPSSNA------...P..TPSAAVV-..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------sgaalvap...................................................
J6EII9_SACK1/3-412                   ............................SIIAADVKLEDLEVALAKNEN..........-ETRDNVCKEISEARDEILPLRLQFNEFIQTMASIDKDG.....PKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTADNKDRSFQLLEPL..................STYN.QNGTVAGP......AAAVVN....TSHSTAASTPTTT...-..TPHANPIAhaHAHSLSQPN.SMAtmqqhsla....................gkrghkgssSIGTPNa...pNSTVAAATAA-----.-TKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QAQ.AQAQ......................V.YSQQS..AVQTP.....ITA--.--..---.....SMAAALP.....NPTPNMIN.SV.SPT..NVMGTPL.TN.........MMSPMA.---..--NGYSWG..GQT.QGgGQPGMPQfnnnGNGTN......PNPSTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNTDFQQQQQPQQpqqpQQqlpQQP-QQQYNM.NM.GMNTMNNNGKE.LDSLDLNNLELGGLNMDFL...........................................................
I2GX35_TETBL/12-175                  ...........................a-LLPKDCNISKLESSLAANPA..........--SHEALQRQLSQMQQQVLPLRLLFNNLLSILSGTND--.....-TIADNEIYYSTVREMVVEISQQLQNISGNMAQLEPILSTVRSYNQ-EPNRSSFSQLLQNLs...............etKSLS.QKFPQPIM......TTASSN....KRSKSQAATPISS...-..TSNQN---..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------vnlssvapap.................................................
J7S5W6_KAZNA/5-316                   ...........................e-LVPNGTKLADLEKRMVEDTM..........--VRDGLVVGLRQVREEILPIRLKFNAFLNKMSHLDSEP.....QGAKTNEERFKEVRDNLLDLYKSIQTLSARFHEIQPLFSVIEQFGAVD--GEKQFCPLETL..................G---.-NGPT---......----VS....SIPTTVPTAPVG-...-..------KK..SAVSTPA--.---.....................................NNDKP-.....----SPSVGPTASSA.AAKKPRKPRQSKK.....TPVHTPAgnpTPRT....AAQT.PLS.VPSS......................-.-SGPG.gDVGVS.....SGAAA.AA..AAS.....AMNSTIS.....MPQHILSS.AM.SPMmgSTMGTPNnMN.........QMSSSQ.---..----QPQA..PQQ.QQ.QQVHA-P....FMGAN......PAASTNNTSA-----..............---QSLTPANILSMN-NGNM...-N-----------....--...----------.--.-----------.-------------------atnaerpe...................................................
W5LTR6_ASTMX/620-729                 .....................kevernp---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..--------..---------.---.....................................------.....-------------PP.QTKRGQKAQANSL.....AHAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.QAQAQ.iQVQAP.....HAFPG.MTgdEFN.....FLRNAVGn..lgNGPP-FVNpFA.APG..N------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------glagppplpplgtalgdv.........................................
C5E049_ZYGRC/9-144                   ...........................e-ILSINMKLDELESKLSSGDS..........--SKESVMGAINETKGSILPMRLKFNDFLQTMSSIDK--.....MQEVSPDEKFLLIKSKLLELTNSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL.................rSATN.GNGND---......------....-------------...-..--------..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----.....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------fsaqqlnqpnq................................................
#=GC seq_cons                        .............................lls.shpL-cLp.hLupsps............s+-tVtppIppsccpILPlRLpFN-FlphMusl-p........tptsp.tKahhIRsKlLpLpsphQplSpchptLQPLFsTlscY.c..psppppFp.LEsL..................ss.s.ppGss.........ssssss....ss.sosusTPss.......t.tusshp..pstshssss.shs.....................................shssPs.....ssssssshss.......sKKPRKsRpsKK.......stutA....sps....tups.ph..tQtp...............................t.tts.....hss...............tM.suhs.....sss..hhs.ss.sP...s.hss....s..............................................................................................................................................................................................................................................
//
DBGET integrated database retrieval system