GenomeNet

Database: Pfam
Entry: Med3
LinkDB: Med3
Original site: Med3 
#=GF ID   Med3
#=GF AC   PF11593.3
#=GF DE   Mediator complex subunit 3 fungal
#=GF AU   Coggill P
#=GF SE   manual
#=GF GA   27.60 27.60;
#=GF TC   27.70 27.70;
#=GF NC   27.20 27.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   10722672
#=GF RT   Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT   polymerase II holoenzyme. 
#=GF RA   Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA   Tzamarias D; 
#=GF RL   J Biol Chem. 2000;275:8397-8403.
#=GF DR   INTERPRO; IPR020998;
#=GF CC   Mediator is a large complex of up to 33 proteins that is
#=GF CC   conserved from plants to fungi to humans - the number and
#=GF CC   representation of individual subunits varying with species. It
#=GF CC   is arranged into four different sections, a core, a head, a tail
#=GF CC   and a kinase-activity part, and the number of subunits within
#=GF CC   each of these is what varies with species. Overall, Mediator
#=GF CC   regulates the transcriptional activity of RNA polymerase II but
#=GF CC   it would appear that each of the four different sections has a
#=GF CC   slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC   physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC   co-repressor [2].
#=GF SQ   30
#=GS A6ZUW9_YEAS7/2-397    AC A6ZUW9.1
#=GS E7NHR1_YEASO/36-352   AC E7NHR1.1
#=GS E7KCN3_YEASA/36-436   AC E7KCN3.1
#=GS E9C6J8_CAPO3/241-351  AC E9C6J8.1
#=GS G8JM86_ERECY/5-332    AC G8JM86.1
#=GS A7TKX4_VANPO/330-509  AC A7TKX4.1
#=GS MED3_CANGA/12-481     AC Q6FXZ4.1
#=GS B4UMX1_CANGA/12-477   AC B4UMX1.1
#=GS MED3_ASHGO/6-331      AC Q752T7.1
#=GS B3LIN8_YEAS1/2-394    AC B3LIN8.1
#=GS E7KNI8_YEASL/36-432   AC E7KNI8.1
#=GS MED3_YEAST/2-397      AC P40356.2
#=GS C7GSA0_YEAS2/2-397    AC C7GSA0.1
#=GS C5DHV2_LACTC/13-351   AC C5DHV2.1
#=GS G2WE69_YEASK/2-397    AC G2WE69.1
#=GS C8Z8L7_YEAS8/36-432   AC C8Z8L7.1
#=GS G8BZH5_TETPH/391-537  AC G8BZH5.1
#=GS H2AZT1_KAZAF/8-256    AC H2AZT1.1
#=GS G8BZH5_TETPH/11-397   AC G8BZH5.1
#=GS E7LUG4_YEASV/36-340   AC E7LUG4.1
#=GS C5E049_ZYGRC/8-145    AC C5E049.1
#=GS B4JUB2_DROGR/183-387  AC B4JUB2.1
#=GS H0GUW1_9SACH/2-406    AC H0GUW1.1
#=GS B5VIT6_YEAS6/2-300    AC B5VIT6.1
#=GS G8ZWS1_TORDC/163-342  AC G8ZWS1.1
#=GS G8ZWS1_TORDC/5-173    AC G8ZWS1.1
#=GS MED3_KLULA/7-317      AC Q6CNQ9.1
#=GS A7TKX4_VANPO/9-335    AC A7TKX4.1
#=GS G0WA71_NAUDC/10-385   AC G0WA71.1
#=GS E7QEW2_YEASZ/36-424   AC E7QEW2.1
A6ZUW9_YEAS7/2-397               ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMASId.....qEEPKQTDRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQQ.QQQQQQQPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
E7NHR1_YEASO/36-352              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...TVVSTNHSTAAS.TPTTTATPHT....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GKWIQ---------------...---------------..........................-------.---.-----------..-------..-----....-------------------skykykl..................................................
E7KCN3_YEASA/36-436              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRPTKKakaq..aqaqAQAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
E9C6J8_CAPO3/241-351             yagddfsdddgdddddddyssrkeetkpapekpkak------------------.-..........---.---------------------------------.......--------------------------------------------------..-----------.............................----EEPPASPSKP...KQQTPAAAAAAA.KPAAAATPAA....APAST..AAASTT.........AATTAAK.............GKDSAKGA.-AATTA.TTTPAA------------..........--------......................---------------......................................---.--------------...----.---......------..........-..............-----.--......-----------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------aagkgi...................................................
G8JM86_ERECY/5-332               ...................................e-EILSAKLTLEELKEKLA.N..........NDE.SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQI.......EHLNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSES-..NEQKFYPLETL.............................NLLPDPIKSTASPS...YKKAVNKSNAET.PSSNAATPSA....ALSSN..NVVLVG.........PQA----.............--------.------.-------KNQRRPRTNNK..........------RQ......................PSGTASAAPSA----......................................---.----GSAGSAPISG...ATPM.M--......ISGVSP..........L..............NMVAS.PL......NGISPNRKPQQ....-----PH...HQTTPTAaTLSI.HSSQQKQIAMQGKGTPSKTP..vLSAANLTPQSILTMS..........................---AFEN.NAN.SIPTSTLSINSgpNQATMGF.sAD---....LDNLDLNALELGSLNMDLL.........................................................
A7TKX4_VANPO/330-509             ...................................n------------------.-..........---.---------------------------------.......--------------------------------------------------..-----------.............................--------------...------------.----------....-----..------.........-------.............--------.------.------------------..........--------......................-------------MM......................................GSLgGVSQDYGMQLQTPN..qPTPLqMQMgq..qgIQQQAPpsqqipqqfnMgnmgnm..nnmgnmNSMGN.-M......NNMGNMGNMNN....MGNMNNM...GNMNNMG.NMGN.MGNMGNMNNM-GNMNNMGNM...---NNITPASILSMN..........................LSLDNQLpQQQ.QHPQQIGQQPD..QQGNNRM..-DTND....FDLLDLNNLDFSG-GMDFV.........................................................
MED3_CANGA/12-481                ....................................SDVLTPSMSLTELEMKFAdE..........TDGkAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLd.....eERYANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTY..KNKNFQVLENL.............................ASYNHRGKAGASIS...---NSTPTPAAA.TPTTAPTPGA....GTKKA..AKTAPT.........PTATATI.............GTPSNNAP.TPATTA.TTPGTQAKKPRKPRQTKKqq.....qaaAAAAAVAQ......................AQAQAQAQAQNQNQNnmqnknisnpgmnsnmgtpvmgnpnmkqmqspipanamNNM.NVPHNGAMRPSVPNgnmGNPS.MGN......LNMNAP..........NmgnpnmnnpnmnnpNAMMS.PMagqgqlNQMFPMQNHNQngqfMGQQSPGpniGQMQFPP.NNGN.MNGMPGTSDMNLGMNPSMNMnmgMNLNQITPANILSMNtkgk..................ddqmQNIGMDQ.NQN.QNQSQNQSQNQ.nQSMNMNM.nNDSNNpksaYDLVDFNSLDLSSLNMDFL.........................................................
B4UMX1_CANGA/12-477              ....................................SDVLTPSMSLTELEMKFAdE..........TDGkAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLd.....eERYANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTY..KNKNFQVLENL.............................ASYNHRGKAGASIS...---NSTPTPAAA.TPTTAPTPGA....GTKKA..AKTAPT.........PTATATI.............GTPSNNAP.TPATTA.TTPGTQAKKPRKPRQTKKqq.....qaaAAAAAVAQ......................AQAQAQAQAQNQNQNnmqnknisnpgmnsnmgtpvmgnpnmkqmqspipanamNNM.NVPHNGAMRPSVPNgnmGNPS.MGN......LNMNAP..........NmgnpnmnnpnmnnpNAMMS.PMagqgqlNQMFPMQNHNQnghfMGQQSPGpniGQMQFPP.NNGN.MNGMPGTSDMNLGMNPSMNMnmgMNMNQITPANILSMNtkgk..................ddqmQNIGMDQ.NQN.QNQNQN----Q.nQSMNMNM.nNDSNNpksaYDLVDFNSLDLSSLNMDFL.........................................................
MED3_ASHGO/6-331                 ....................................DGILRENLTLEELQEWLT.S..........TEG.NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHI.......EQLSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSET-..SERKFYPKETL.............................GTAVEPVRPLASPS...YRRPSNRSSADT.PSSNAPTPSA....AVVSG..A-ALVA.........PQV----.............--------.------.-------KHQRRPRTNT-..........----AKRQ......................PSVSASVVPSA----......................................---.----NSSGPATIPG...ATPL.M--......LSGMSP..........L..............NMVAS.PL......NGISPSRKPAQ....-----PH...HQTTPSA.ALGM.QPMQQKQMSIQAKATPSKSG..tINSANLTPQSILNMS..........................---AFEN.SAG.GVPNSAVPLNQ.nNNAIMGF.pTDIDN....---IDLNALELGSLNMDLL.........................................................
B3LIN8_YEAS1/2-394               ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPYA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........AKAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
E7KNI8_YEASL/36-432              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKKak......aqAQAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggxeLDSLDLNNLELGGLNMDFL.........................................................
MED3_YEAST/2-397                 ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...TVVSTNHSAAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQQ.QQQQQQQPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
C7GSA0_YEAS2/2-397               ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...TVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQQ.QQQQQQQPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
C5DHV2_LACTC/13-351              ................................lkef--------DFGNLHEKLE.S..........EDG.YKDSVKQEIQSVQDSIQPMRLRFNELLNMLAII.......DQETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGG.kTSIKFTPLERL.............................R-----HLSDASLG...-------NQAKS.AS-GGSPPAA....AVASV..PTTTKQ.........PKSST--.............----NTPT.SNAATPsATFNAAAKKSRKSRSKKNslptglgghpVATAASPA......................AVAA--AAAAV-STN......................................PGV.AMGSNPGIQQQFTP...STNP.TQI......LSSMSP..........M..............NMMSS.PM......NIMSPANNVNM....-------...------A.YTGPtKPPVPSHR----HMPSSSQQ...MNMNGITPANILNMS..........................----MME.QAN.QPHLTTAPAPQ..--PPNQL..-DMNN....---LDLNNLDLSNLNMDFL.........................................................
G2WE69_YEASK/2-397               ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...TVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQQ.QQQQQQQPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
C8Z8L7_YEAS8/36-432              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKKak......aqAQAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggeeLDSLDLNNLELGGLNMDFL.........................................................
G8BZH5_TETPH/391-537             ...................................m------------------.-..........---.---------------------------------.......--------------------------------------------------..-----------.............................--------------...------------.----------....-----..------.........-------.............--------.------.------------------..........--------......................---------------......................................---.--------------...----.---......------..........-..............NGMSN.-M......NNMNGMNNVNN....MGNMANM...NNMNNMA.NMNN.MNNMNNMNHM-GNMNNMK--...MNMNSITPANILSMNvpqdvnaintnnkttanktnkasksnKPAKTNQ.TQG.QSQSRNQPQAQ..QTGSQSIgnLDMNE....FDLLDLNNLDFGG-NIDF-g........................................................
H2AZT1_KAZAF/8-256               ....................................SEVLTLTVKLEELETKFA.T..........NEN.SKQSVLDLVNETRSLILPIRLQLNEFISLMANI.......DKMTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYSTKH..NSREFKPLESL.............................S---NDPFAKGSPR...--TTSSGSANNTiTSATSITTNA....NNKI-..--SAAT.........PSS--NI.............----NTPA.SSSQNI.TNTTPSIKKPRKPRQPRK..........SITQTNTA......................NKASKTTTPSA----......................................---.--PTPVAAPMQTPGtmnPALP.VQN......FNTKTP..........I..............N-LGS.P-......-----------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------ngpqfsp..................................................
G8BZH5_TETPH/11-397              ..............................ffntve--------SLENLEDKLV.M..........NNFeNKDILMEKISSTQKSILPIRLLFNEFIQTMALLndgkghkTENNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSLKN..NSKQFDPLETLkqidnd.................vfnsqaALATNAADSQNNGK...TKAKNSTSTAAT.PNSSVNTPITnlgsQTILS..NTNASV.........PALATTPttvt....kgasvASASSKSVtANLSSV.NVPAATTKKPRKPRQTKK.........sTATSKKLQsnsaaspmnpptpsnitankraNKASA-QTA-----Qstgnmlgmngsqqnv.......agnmnnnnnnnmvqrnN--.----SISMNS----...-QDF.MAMqykngnGNGNAP..........M.............nNQMMNnQMi....nNQMINNQMLNQq..qM-KMNNM...GNMN-MG.NMGN.MGNMNNINNMN----GMSN-...---------------..........................-------.---.-----------..-------..-----....-------------------m........................................................
E7LUG4_YEASV/36-340              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRXTKKak......aqAQAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQXXG...G------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------ts.......................................................
C5E049_ZYGRC/8-145               ....................................SEILSINMKLDELESKLS.S..........GDS.SKESVMGAINETKGSILPMRLKFNDFLQTMSSI.......DKMQEVSPDEKFLLIKSKLLELTNSMQQVSEEFTKLQPLFDTVPEYAERY..GNKRYLPLETL.............................RSATNGNGNDFSA-...------------.----------....-----..------.........-------.............--------.------.------------------..........--------......................---------------......................................---.--------------...----.---......------..........-..............-----.--......-----------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------qqlnqpnqq................................................
B4JUB2_DROGR/183-387             ...............................mshay------------------.-..........---.---------------------------------.......--------------------------------------------NYQETY.pVPDKYYDVEVL.............................VVASPFPPPEPTTS...TT-TTTTTTTTT.TTTTTTTPAT....TTSTS..TTSTTT.........PATTTTT............sTTPATTTT.TPATTT.TTTSTTPKPSRQRRDTNQ..........TMHANARLl....................gLNLAAAVQQQMQQNN......................................NGN.NRSVNKSSVAL---...----.---......------..........-..............-----.--......-----------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------inplgvlrprqllqappppydcvdgniiakdpnntygyfkrrivtktpisnfsskgk
H0GUW1_9SACH/2-406               ....................................DSIITADVKLEDLEVALA.K..........NENeTRDNVCKEISEARDEILPLRLQFNEFIQTMASId.....kDGPKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTAdnKDRSFQLLEPL.............................STYNQNGTVAGPAA...AVVNTSHSTAAS.TPTTT-TPHA....NPIAHahAHSLSQ.........PNSMATMqqhslagkrghkgSSSIGTPN.APNSTV.AAATAATKKPRKPRQTKKa........kAQAQAQAQ......................AQAQAQAQAQVYSQQ......................................SAV.QTPITASMAAALPN...PTPN.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMANGYS....LGGQTQG..gGQPAMPQ.FNNN.GNGTNPNPSTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNTDFQQ.QQQpQQQPPQQPQQQ..YNMNMGM..NTMNNngkeLDSLDLNNLELGGLNMDFL.........................................................
B5VIT6_YEAS6/2-300               ..................................at------------------.-..........---.---------------------------------.......--------------------------------------LFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRPTKK..........AKAQAQAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
G8ZWS1_TORDC/163-342             ................................pmgs------------------.-..........---.---------------------------------.......--------------------------------------------------..-----------.............................--------------...------------.----------....-----..------.........-------.............--------.---AVP.TPYATTAKKPRKPRQPKKpq......tpAAAAAAAA......................VAANGHIKSQA----......................................---.SPTPPAHMVSSVPA...-TNP.VQM......VNSVPP..........T..............NMMGT.PM.....qNLMSPLGNTPN....YGFSQQQ...SQQQPTP.QQ--.-QQRQQYNSATKNSTMPQSQ..pMNLNSITPANILSMS..........................MTGDPLH.-QQ.QQQNK------..-------..---KE....FDPLDFNNLDFGNLNMDMI.........................................................
G8ZWS1_TORDC/5-173               ....................................SDLLVPDMKLEELETSLAtG..........GDD.PKDRVDKAITDAQNSILPMRLQFNDFMHTMSNI.......DDLQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSEKY..GTKKFQPLETLripq.....................snsvSSPQTQNNAIVGAN...LNKKANRSNDGT.PVSQTSTPMG....SAV--..------.........-------.............--------.------.------------------..........--------......................---------------......................................---.--------------...----.---......------..........-..............-----.--......-----------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------ptpya....................................................
MED3_KLULA/7-317                 ....................................DQIFKDNLTFDTFRELII.E..........KES.TADEVADKVLEAKKALLPIRTLMTEFVGMIANL.......ESMGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVnaGEKKFFVQETL.............................G-YTQLASNGSAAG...ITKTSSGNDGNT.TGSTANTMAM....AKGLK..KNAAGK.........PNTGTGV.............--------.------.------QSGPGRRNSTKKtg.....htgPATAPTTS......................NSAASAAAAAA----......................................---.----NTPSLKQIPN...-TQP.MQL......MPGVSP..........M..............-AMAS.PL......NNISPQRKLTQ....-------...-------.----.HVNQSRENSLHQGVTPSASM...-----ITPQNILNMS..........................---AFDL.NQN.QTPQSL-----..-------..DNVNN....---MDLTNLDLDSLNMEFL.........................................................
A7TKX4_VANPO/9-335               ....................................STILSGKVKLEQLEDTLG.L..........DDN.SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHI.......EEQPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKY..KNKKYQPLETLyqsstgatttitssantsngpsvtgstsaGSAANTPNVSASAS...TTTKRAKSNAAT.PSSATNTPNAs..gASVGT..PNSASAgitsgsgitPIPTTGVsa.........asGSAATTAAsISATTP.TTTTTTVKKPRKPRQPKK..........TAAANKKQpvpspln........sqiplntASINNNNTSSAYNNM......................................KAN.NTNMKM-----APNagpMNNQ.AQM......MGNPSP..........K..............NMVNT.PL......NNMM-------....-------...-------.----.--------------------...---------------..........................-------.---.-----------..-------..-----....-------------------gsl......................................................
G0WA71_NAUDC/10-385              ...................................s-KLLTPKLTLDQLEDRLAgDidnldttdlsDDSlPKQVIANSLIETEKSILPLRLVFNKLIQTMATL.......DTMPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSEKN..NTKKFHMLETL.............................KPIVEPAPATAKATkgdASHSKKKSVAGT.PGSVGNTPVG....TTPGS..STGTVA.........ANVPANI............nANTTNTSTtSAASTT.QTTSSTAKKPRKPRQNKK..........AAAKA--Q......................QQQQQQLLQQQQQQQi....................................pKQQ.GIATNPMMNMNAMN...ATPM.M--......-NSVSP..........S..............NVMGT.PL.....nNGISPMGAVMA....GGFYSQP...PGSQSQQ.FDQQ.MNN----GDHNTNNNNFQNM...---NNITPANILSMN..........................---TVGD.PQS.RMASSSQQYPT..NN-----..-NNNN....--TLDLNNLDLSSLNMDFL.........................................................
E7QEW2_YEASZ/36-424              ....................................DSIIPAGVKLDDLQVILA.K..........NENeTRDKVCKQINEARDEILPLRLQFNEFIQIMANId.....qEGPKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTAdnRDRSFQLLEPL.............................STYNKNGNAVCSTA...AVVSTNHSTAAS.TPTTTATPHA....NPITH..AHSLSN.........PNSTATMqhnplagkrgpksGSTMGTPT.VHNSTA.AAPIAAPKKPRKPRQTKK..........----AKAQ......................AQAQAQAQAQVYAQQ......................................STV.QTPITASMAAALPN...PTPS.M--......INSVSP..........T..............NVMGT.PL.....tNMMSPMGNAYS....MGAQNQG...GQVSMSQ.FNGS.GNGSNPNTNTNSNNTPLQSQ...LNLNNLTPANILNMS..........................MNNDFQQ.QQ-.------QPQPQ..YNMNMGM..NNMNNggkeLDSLDLNNLELGGLNMDFL.........................................................
#=GC seq_cons                    ....................................spllssslpL--LpshLA.p..........s-s.s+DpVsppIpcsccpILPLRLpFN-FlphMusI.......-t.ppssp.tKaLhIRsKlLpLss+hQsLSpchptLQPLFsTlsEY.coh..ps+pFp.LEsL.............................uohscsusAssSsu...tshsos+SsAAo.TsoTssTPtA....sshsp..upohss.........Psoossh.............uos.sTss.stsoTs.ssshsssKKPRKPRpTKK..............ApsQ......................spApApApAQs.tpp......................................ss..psshsuuMsuslPN...sTPs.M........lNusSP..........p..............NsMuo.PL......NhMSPMsNs.p....hGt.s.t...uphp..t...us.hss.s..sshpts.ss.ps....hs.NslTPANILsMs.............................shpp.pQ............p...p...th...s.Ns.......lDLNsL-LuuLNMDFL.........................................................
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