GenomeNet

Database: Pfam
Entry: Med3
LinkDB: Med3
Original site: Med3 
#=GF ID   Med3
#=GF AC   PF11593.5
#=GF DE   Mediator complex subunit 3 fungal
#=GF AU   Coggill P
#=GF SE   manual
#=GF GA   27.60 27.60;
#=GF TC   27.60 27.60;
#=GF NC   27.50 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   10722672
#=GF RT   Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT   polymerase II holoenzyme. 
#=GF RA   Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA   Tzamarias D; 
#=GF RL   J Biol Chem. 2000;275:8397-8403.
#=GF DR   INTERPRO; IPR020998;
#=GF CC   Mediator is a large complex of up to 33 proteins that is
#=GF CC   conserved from plants to fungi to humans - the number and
#=GF CC   representation of individual subunits varying with species. It
#=GF CC   is arranged into four different sections, a core, a head, a tail
#=GF CC   and a kinase-activity part, and the number of subunits within
#=GF CC   each of these is what varies with species. Overall, Mediator
#=GF CC   regulates the transcriptional activity of RNA polymerase II but
#=GF CC   it would appear that each of the four different sections has a
#=GF CC   slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC   physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC   co-repressor [2].
#=GF SQ   26
#=GS J4WEV1_BEAB2/713-874  AC J4WEV1.1
#=GS E7QEW2_YEASZ/37-424   AC E7QEW2.1
#=GS A7TKX4_VANPO/10-396   AC A7TKX4.1
#=GS E7LUG4_YEASV/37-340   AC E7LUG4.1
#=GS G8ZWS1_TORDC/6-322    AC G8ZWS1.1
#=GS S6EL77_ZYGB2/8-332    AC S6EL77.1
#=GS G0WA71_NAUDC/11-385   AC G0WA71.1
#=GS E7NHR1_YEASO/37-346   AC E7NHR1.1
#=GS G8JM86_ERECY/6-202    AC G8JM86.1
#=GS C5DHV2_LACTC/14-351   AC C5DHV2.1
#=GS E7KNI8_YEASL/37-432   AC E7KNI8.1
#=GS MED3_CANGA/13-481     AC Q6FXZ4.1
#=GS G8BZH5_TETPH/11-420   AC G8BZH5.1
#=GS B4UMX1_CANGA/13-477   AC B4UMX1.1
#=GS J8LNQ4_SACAR/3-398    AC J8LNQ4.1
#=GS MED3_KLULA/8-228      AC Q6CNQ9.1
#=GS E7KCN3_YEASA/37-436   AC E7KCN3.1
#=GS H2AZT1_KAZAF/9-258    AC H2AZT1.1
#=GS MED3_YEAST/3-397      AC P40356.2
#=GS B4JUB2_DROGR/189-379  AC B4JUB2.1
#=GS MED3_ASHGO/7-167      AC Q752T7.2
#=GS J6EII9_SACK1/3-412    AC J6EII9.1
#=GS I2GX35_TETBL/12-175   AC I2GX35.1
#=GS J7S5W6_KAZNA/5-316    AC J7S5W6.1
#=GS W5LTR6_ASTMX/620-729  AC W5LTR6.1
#=GS C5E049_ZYGRC/9-144    AC C5E049.1
J4WEV1_BEAB2/713-874             ..............qsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..---ANTKN.lDTSEVPIPT.TIE.....................................ELSPPVr..thRSSSWGPVAATSPSE.EQRSPRNGNSNHD.....--AQSQA...QQQQ....QQQQhQHQ.QQQQ......................-.--YQQ..QQQQQ....IAQNGdFD..SFD.....SM-SSFP....gDPSAMVMD.PP.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------fpqpllpqdlfalpmtldwnwaemsggaypsvengn.......................
E7QEW2_YEASZ/37-424              ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
A7TKX4_VANPO/10-396              ...........................t-ILSGKVKLEQLEDTLGLDDN..........--SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEE--.....QPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKK--YQPLETLyqss..........tgatTTIT.SSANTSNG......PSVTGS....TSAGSAANTPNVS...A..SASTTTKR..AKSNAATPS.SATntpnasgasvgtpnsasagitsgsgitpipttgvsaaSGSAAT.....TAASISATTPTTTTT.TVKKPRKPRQPKK.....---TAAA...NKKQ....PVPS.PLN.SQIP......................LnTASIN..NNNTS....SAYNN.MK..ANNt..nmKMAPNAGp...mNNQAQMMG.NP.SPK..NMVNTPL.NN.........MMGSLG.G--..VSQDYGMQlqTPN.QP.TPLQMQM...gQQGIQq...qaP----PSQQIPQQFNmg..........nmGNMNNMG-----NM------...-------------....--...----------.--.-----------.-------------------nsmg.......................................................
E7LUG4_YEASV/37-340              ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRXTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAQQS..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQX.XG.G------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------ts.........................................................
G8ZWS1_TORDC/6-322               ............................DLLVPDMKLEELETSLATGGD..........-DPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDD--.....LQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSE--KYGTKKFQPLETL..................RIPQ.SN------......----SV....SSPQTQNNAIV--...-..--GANLNK..KANRSNDGT.PVS.....................................QTSTPM.....GSAVPTPY-----AT.TAKKPRKPRQPKK.....PQTPAAA...AAAAa..vAANG.HIK.SQAS......................-.-----..----P....TPP--.--..--A.....HMVSSVPa...tNPVQ-MVN.SV.PPT..NMMGTPM.QN.........LMSPLG.-NT..PNYGFSQQ..QSQ.QQ.PTPQQQ-....-QRQQ......YNSATKNSTMPQSQP..............MNLNSITPANILSMSMTGDP...----LHQQQQQNK....--...----------.--.-----------.-------------------k..........................................................
S6EL77_ZYGB2/8-332               ............................DILSINMKLDELELKLASTNG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTSSMQNVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETLksstnl.....gnglasqTQLQ.QQQQQQSQ......AQAQVQ....SQQQSQSQQPQSQ...PqqLPNGNPVS..SSNSI----.--Asrk..............................psksNAGTPG.....SNMNTPSGTTMTNMTpSSKKQRKPRQPKK.....TSS---G...IGMG....PAST.PVM.SASN......................-.-FKAQ..TAQSP...qVGT--.--..---.....KI-AGAP....lNNTTQTVS.SV.PPT..STMNTPM.NN.........VMSPLG.GVApgFGISQSQP..PQS.MP.QQISQQF....S----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------qqlsqqrqqqvqqq.............................................
G0WA71_NAUDC/11-385              ............................KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--.....MPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTKKFHMLETLkpiv.........epapaTAKA.TKGDASHS......KKKSVA....GTPGSVGNTPVGT...-..TPGSSTGT..VAANVPA--.---.....................................NINANTt...nTSTTSAASTTQTTSS.TAKKPRKPRQNKK.....----AAA...KAQQ....QQQQ.QLL.QQQQ......................-.-----..QQQIPkqqgIATNP.MM..NMN.....AM-----.....NATP-MMN.SV.SPS..NVMGTPL.NN.........GISPMG.AVM..AGGFYSQP..PGS.QS.QQFDQQM....NNGDH......---NTNNNNF-----..............QNMNNITPANILSMNTVGDP...------QSRMASS....SQ...QYP-------.--.-TNNNNNN---.--TLDLNNLDLSSLNMDFL...........................................................
E7NHR1_YEASO/37-346              ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TATVVS....TNHSTAASTPTTT...A..TPHTNPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQ....FNGS-......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------gkwiqs.....................................................
G8JM86_ERECY/6-202               ............................EILSAKLTLEELKEKLANNDE..........--SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQIEH--.....LNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSE--SNE-QKFYPLETLn................lLPDP.IKSTASPS......YKKAVNksnaETPSSNAATPSA-...-..----ALSS..NNVVLVGPQ.AKNqrr..............................prtnNKRQPS.....GTASAAPSA------.-------------.....-------...----....----.---.----......................-.-----..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------gsagsapis..................................................
C5DHV2_LACTC/14-351              .....................kefdfgn-----------LHEKLESED-..........-GYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQ--.....ETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSI-KFTPLERLr................hLSDA.SLGNQA-K......SASGGS....PPAAAVASVPTTT...K..QPKSSTNT..PTSNAATPS.ATF.....................................NA----.....---------------.AAKKSRKSRSKKNslptgL--GGHP...VATA....ASPA.AVAaAAAA......................V.STNPG.vAM---....-GSNP.GI..QQ-.....QFTPS-T.....NPTQ-ILS.SM.SPM..NMMSSP-.MN.........IMSPAN.--N..VNMAYT--..---.--.-------....--GPT......KPPVPSHRHMPSSSQ.............qMNMNGITPANILNMS-----...MMEQANQPHLTTA....PA...PQPPNQ----.-L.DM----NN---.---LDLNNLDLSNLNMDFL...........................................................
E7KNI8_YEASL/37-432              ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAQQS..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGXE.LDSLDLNNLELGGLNMDFL...........................................................
MED3_CANGA/13-481                ............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..................ASYN.HRGKA---......GASISN....STPTPAAATPTTA...P..TPGAGTKK..AAKTAPTPT.ATA.....................................TIGTPS.....NNAPTPATTATTPGT.QAKKPRKPRQTKKq..qqAAAAAAA...VAQA....QAQA.QAQ.AQNQnqnnmqnknisnpgmnsnmgtpV.MGNPNmkQMQSP....IPANA.MN..NMNvphngAMRPSVPngnmgNPSMGNLN.MN.APN..--MGNPN.MNnpnmnnpnaMMSPMAgQGQ..LNQMFPMQ..NHN.QN.GQFMGQQ....SPGPNigqmqfPPNNGNMNGMPGTSDmnlgmnpsmnmnmgMNLNQITPANILSMNTKGKDdqmQNIGMDQNQNQNQ....SQ...NQSQNQNQSM.NM.NMNNDSNNPKSaYDLVDFNSLDLSSLNMDFL...........................................................
G8BZH5_TETPH/11-420              ......................ffntve-------SLENLEDKLVMNNF..........-ENKDILMEKISSTQKSILPIRLLFNEFIQTMALLNDGKghkteNNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSL--KNNSKQFDPLETLkqidndvfnsqaalatnaADSQ.NNGKTKAK......NSTSTA....ATPNSSVNTPITNlgsQ..TILSNTNA..SVPALATTP.TTV.....................................TKGASVasassKSVTANLSSVNVPAA.TTKKPRKPRQTKK.....STATS-K...KLQS....NSA-.---.----......................-.-ASPM..NPPTPs..nITANK.RA..NKA.....SAQTA--.....QSTGNMLG.MNgSQQ..NVAGNMN.NN.........NNNNMV.--Q..RNNSISMN..SQDfMA.MQYKNGN....GNGNA......PMNNQMMNNQMINNQminnq...mlnqqqMKMNNMGNMNMGNMGNMGNM...NNIN-NMNGMSNM....NN...MNGMNNVNNMgNMaNMNNMNN----.-------------------...........................................................
B4UMX1_CANGA/13-477              ............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..................ASYN.HRGKA---......GASISN....STPTPAAATPTTA...P..TPGAGTKK..AAKTAPTPT.ATA.....................................TIGTPS.....NNAPTPATTATTPGT.QAKKPRKPRQTKKq..qqAAAAAAA...VAQA....QAQA.QAQ.AQNQnqnnmqnknisnpgmnsnmgtpV.MGNPNmkQMQSP....IPANA.MN..NMNvphngAMRPSVPngnmgNPSMGNLN.MN.APN..--MGNPN.MNnpnmnnpnaMMSPMAgQGQ..LNQMFPMQ..NHN.QN.GHFMGQQ....SPGPNigqmqfPPNNGNMNGMPGTSDmnlgmnpsmnmnmgMNMNQITPANILSMNTKGKDdqmQNIGMDQNQNQNQ....NQ...N----QNQSM.NM.NMNNDSNNPKSaYDLVDFNSLDLSSLNMDFL...........................................................
J8LNQ4_SACAR/3-398               ............................SIIPADTKLEDLEVKLAKNEN..........-ETRDNVCKQINEARNEILPLRLQFNEFIQSMANIDHDG.....TKQGDRMVKYLHIRDSILQLNDRFQSLSSHLETLQPLFNTVPEYLRTADNKDRSFQLLEPL..................STYN.QNGTVTGP......AAAVAN....TSHSTAASTPTT-...-..TPHANSNA..HTHSLSNPN.TTTammqqnpma...................gkrgpkgstTIGTP-.....NSAAAAATAA-----.-AKKPRKPRQTKK.....AKAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.YAHPS..AVQTP....ITA--.--..---.....SMTAALP.....NPTPNIIN.SV.SPT..NVMGTPL.TN.........MMSPMT.---..--NAYSMV..APN.QG.GQPAMSQftnhSNGTN......PNPTTNANNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQQQQ....QP...QQPQQQQYN-.--.-MNTMNNNGKE.LDSLDLNNLELGGLNMDFL...........................................................
MED3_KLULA/8-228                 ...........qifkdnltfdtfrelii-----------------E-KE..........-STADEVADKVLEAKKALLPIRTLMTEFVGMIANLES--.....MGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVNAGEKKFFVQETLg................yTQLA.SNGSAAGI......TKTSSG....NDGNTTGSTANTM...-..AMAKGLKK..NAAGKPN-T.GTGvqsgpgrrns.................tkktghtgpaTAPTTS.....NSAASAAAAAANTPS.-------------.....-------...----....----.---.----......................-.-----..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------lkqipntqpmq................................................
E7KCN3_YEASA/37-436              ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....PKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TAAVVS....TNHSTAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRPTKK.....AKAQAQA...QAQAqaqaQAQA.QAQ.AQAQ......................V.YAQQS..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQ-----....--...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
H2AZT1_KAZAF/9-258               ...........................e-VLTLTVKLEELETKFATNEN..........--SKQSVLDLVNETRSLILPIRLQLNEFISLMANIDK--.....MTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYST--KHNSREFKPLESL..................SNDPfAKGSP--R......TTSSGS....ANNTITSATSITT...-..--NANNKI..SAAT-----.PSS.....................................NINTPA.....SS--SQNITNTTP--.SIKKPRKPRQPRK.....------S...ITQT....NTAN.KAS.KT--......................-.-TTPS..-APTP....VAA-P.MQ..TPG.....TMNPALPv...qN-----FN.TK.TPI..N-LGSPN.GP.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------qfsppp.....................................................
MED3_YEAST/3-397                 ............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..................STYN.KNGNAVCS......TATVVS....TNHSAAASTPTTT...A..TPHANPIT..HAHSLSNPN.STAtmqhnpla....................gkrgpksgsTMGTPTv...hNSTAAAPIAA-----.-PKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QVY.AQQS......................-.-----..TVQTP....ITA--.--..---.....SMAAALP.....NPTPSMIN.SV.SPT..NVMGTPL.TN.........MMSPMG.---..--NAYSMG..AQN.QG.GQVSMSQfngsGNGSN......PNTNTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQQQQ....QQ...QQPQPQ-YNM.NM.GMNNMNNGGKE.LDSLDLNNLELGGLNMDFL...........................................................
B4JUB2_DROGR/189-379             yqetypvpdkyydvevlvvaspfpppep---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......TTSTTT....TTTTTTTTTTTTT...T..TPATTTST..STTSTTTPAtTTT.....................................TSTTPA.....TTTTTPATTTTTTST.TPKPSRQRRDTNQt..mhANARLLG...LNLA....AAVQ.QQM.QQNN......................-.NGNN-..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------rsvnkssvalinplgvlrprqllqappppydcvdgniiakdpnntygyfkrrivtktpi
MED3_ASHGO/7-167                 ...........................g-ILRENLTLEELQEWLTSSEG..........--NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQ--.....LSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSETS---ERKFYPKETL..................GTAV.EPVRPLASpsyrrpSNRSSA....DTPSSNA------...P..TPSAAVV-..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------sgaalvap...................................................
J6EII9_SACK1/3-412               ............................SIIAADVKLEDLEVALAKNEN..........-ETRDNVCKEISEARDEILPLRLQFNEFIQTMASIDKDG.....PKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTADNKDRSFQLLEPL..................STYN.QNGTVAGP......AAAVVN....TSHSTAASTPTTT...-..TPHANPIAhaHAHSLSQPN.SMAtmqqhsla....................gkrghkgssSIGTPNa...pNSTVAAATAA-----.-TKKPRKPRQTKK.....--AKAQA...QAQA....QAQA.QAQ.AQAQ......................V.YSQQS..AVQTP....ITA--.--..---.....SMAAALP.....NPTPNMIN.SV.SPT..NVMGTPL.TN.........MMSPMA.---..--NGYSWG..GQT.QGgGQPGMPQfnnnGNGTN......PNPSTNSNNTPLQSQ..............LNLNNLTPANILNMS-----...MNTDFQQQQQPQQpqqpQQqlpQQP-QQQYNM.NM.GMNTMNNNGKE.LDSLDLNNLELGGLNMDFL...........................................................
I2GX35_TETBL/12-175              ...........................a-LLPKDCNISKLESSLAANPA..........--SHEALQRQLSQMQQQVLPLRLLFNNLLSILSGTND--.....-TIADNEIYYSTVREMVVEISQQLQNISGNMAQLEPILSTVRSYNQ-EPNRSSFSQLLQNLs...............etKSLS.QKFPQPIM......TTASSN....KRSKSQAATPISS...-..TSNQN---..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------vnlssvapap.................................................
J7S5W6_KAZNA/5-316               ...........................e-LVPNGTKLADLEKRMVEDTM..........--VRDGLVVGLRQVREEILPIRLKFNAFLNKMSHLDSEP.....QGAKTNEERFKEVRDNLLDLYKSIQTLSARFHEIQPLFSVIEQFGAVD--GEKQFCPLETL..................G---.-NGPT---......----VS....SIPTTVPTAPVG-...-..------KK..SAVSTPA--.---.....................................NNDKP-.....----SPSVGPTASSA.AAKKPRKPRQSKK.....TPVHTPAgnpTPRT....AAQT.PLS.VPSS......................-.-SGPG.gDVGVS....SGAAA.AA..AAS.....AMNSTIS.....MPQHILSS.AM.SPMmgSTMGTPNnMN.........QMSSSQ.---..----QPQA..PQQ.QQ.QQVHA-P....FMGAN......PAASTNNTSA-----..............---QSLTPANILSMN-NGNM...-N-----------....--...----------.--.-----------.-------------------atnaerpe...................................................
W5LTR6_ASTMX/620-729             .....................kevernp---------------------..........---------------------------------------.....-------------------------------------------------------------..................----.--------......------....-------------...-..--------..---------.---.....................................------.....-------------PP.QTKRGQKAQANSL.....AHAQAQA...QAQA....QAQA.QAQ.AQAQ......................V.QAQAQ.iQVQAP....HAFPG.MTgdEFN.....FLRNAVGn..lgNGPP-FVNpFA.APG..N------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------glagppplpplgtalgdv.........................................
C5E049_ZYGRC/9-144               ...........................e-ILSINMKLDELESKLSSGDS..........--SKESVMGAINETKGSILPMRLKFNDFLQTMSSIDK--.....MQEVSPDEKFLLIKSKLLELTNSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL.................rSATN.GNGND---......------....-------------...-..--------..---------.---.....................................------.....---------------.-------------.....-------...----....----.---.----......................-.-----..-----....-----.--..---.....-------.....--------.--.---..-------.--.........------.---..--------..---.--.-------....-----......---------------..............--------------------...-------------....--...----------.--.-----------.-------------------fsaqqlnqpnq................................................
#=GC seq_cons                    .............................lls.shpL--Lp.hLApsps............s+-tVtppIpcsccpILPlRLpFN-FlphMusIDp........ppssp.tKahhIRsKlLpLssphQsLSpchppLQPLFsTlsEY.ct.cNppppFp.LEsL..................sshs.ppGss.........ssssss....ss.sosusTPsos......ostusshp..pspshssss.sss.....................................shssPs.....sossssshss.......sKKPRKPRpsKK.......stutA....spu....tups.ph..sQtp...............................t.tsP....hss...............tMtsuhs.....Nss..hhs.ss.uPt..s.husP...N..........hushs...........s...................................................................................................................................................................................................................
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