GenomeNet

Database: Pfam
Entry: Merozoite_SPAM
LinkDB: Merozoite_SPAM
Original site: Merozoite_SPAM 
#=GF ID   Merozoite_SPAM
#=GF AC   PF07133.8
#=GF DE   Merozoite surface protein (SPAM)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_15860 (release 10.0)
#=GF GA   27.50 27.50;
#=GF TC   29.30 29.30;
#=GF NC   26.70 25.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7891748
#=GF RT   Molecular variation in a novel polymorphic antigen associated
#=GF RT   with Plasmodium falciparum merozoites. 
#=GF RA   McColl DJ, Silva A, Foley M, Kun JF, Favaloro JM, Thompson JK,
#=GF RA   Marshall VM, Coppel RL, Kemp DJ, Anders RF; 
#=GF RL   Mol Biochem Parasitol 1994;68:53-67.
#=GF RN   [2]
#=GF RM   7893643
#=GF RT   Solution structure of a polypeptide containing four heptad
#=GF RT   repeat units from a merozoite surface antigen of Plasmodium
#=GF RT   falciparum. 
#=GF RA   Mulhern TD, Howlett GJ, Reid GE, Simpson RJ, McColl DJ, Anders
#=GF RA   RF, Norton RS; 
#=GF RL   Biochemistry 1995;34:3479-3491.
#=GF DR   INTERPRO; IPR010784;
#=GF DR   SCOP; 1psm; fa;
#=GF CC   This family consists of several Plasmodium falciparum SPAM
#=GF CC   (secreted polymorphic antigen associated with merozoites)
#=GF CC   proteins. Variation among SPAM alleles is the result of
#=GF CC   deletions and amino acid substitutions in non-repetitive
#=GF CC   sequences within and flanking the alanine heptad-repeat domain.
#=GF CC   Heptad repeats in which the a and d position contain hydrophobic
#=GF CC   residues generate amphipathic alpha-helices which give rise to
#=GF CC   helical bundles or coiled-coil structures in proteins. SPAM is
#=GF CC   an example of a P. falciparum antigen in which a repetitive
#=GF CC   sequence has features characteristic of a well-defined
#=GF CC   structural element [1,2]. 
#=GF SQ   27
#=GS W7JSM4_PLAFO/262-423    AC W7JSM4.1
#=GS A5KAV5_PLAVS/740-898    AC A5KAV5.1
#=GS Q7RQS5_PLAYO/117-315    AC Q7RQS5.1
#=GS W7K323_PLAFO/528-697    AC W7K323.1
#=GS Q8IJ45_PLAF7/571-762    AC Q8IJ45.1
#=GS A5KAV6_PLAVS/951-1139   AC A5KAV6.1
#=GS A5KDU7_PLAVS/513-670    AC A5KDU7.1
#=GS Q8IJ48_PLAF7/237-404    AC Q8IJ48.1
#=GS B3L2C1_PLAKH/525-704    AC B3L2C1.1
#=GS A5KAV3_PLAVS/932-1110   AC A5KAV3.1
#=GS W7KDK7_PLAFO/184-370    AC W7KDK7.1
#=GS Q8IJ55_PLAF7/195-353    AC Q8IJ55.1
#=GS B3LD32_PLAKH/777-919    AC B3LD32.1
#=GS A5KAV1_PLAVS/739-899    AC A5KAV1.1
#=GS Q8IJ53_PLAF7/262-423    AC Q8IJ53.1
#=GS A5KAV7_PLAVS/742-906    AC A5KAV7.1
#=GS W7JSL9_PLAFO/163-330    AC W7JSL9.1
#=GS Q8IJ54_PLAF7/184-370    AC Q8IJ54.1
#=GS A5KAW0_PLAVS/692-851    AC A5KAW0.1
#=GS W7JS07_PLAFO/187-345    AC W7JS07.1
#=GS A5KAV8_PLAVS/1062-1242  AC A5KAV8.1
#=GS B3L6P2_PLAKH/816-960    AC B3L6P2.1
#=GS W7K320_PLAFO/571-762    AC W7K320.1
#=GS Q8IJ52_PLAF7/528-697    AC Q8IJ52.1
#=GS A5KAV4_PLAVS/939-1125   AC A5KAV4.1
#=GS A5KAV2_PLAVS/863-1015   AC A5KAV2.1
#=GS Q4Y5Z4_PLACH/208-350    AC Q4Y5Z4.1
W7JSM4_PLAFO/262-423               .................GIEFSGGLYfnEKKSTEENKQKNVLESVNLTSWDKEDIVKENEDV--------...........----KDEKDEDD-.E.........EEEEKYENEI....IKQPEDIL...DE...EEVLEEEI..LEEN..K---------..--NDT.VDTSdlEKKNI.PDL.S......NDNNYYSLIY...................KNYKDNDKS.EKTAQTLITALISLLNGKNE.LDATIRRLKHRFMEFFTY..
A5KAV5_PLAVS/740-898               ............eflkt---------..--------KNQDILEPVEMFSGGTENVTDREEQV-KDEVEEQ...........GDGSNEKAEEEEE.E.........DSESALPNGS....-DGLEDDV...DL...---DVDDD..VEEE..E--NVATNHQ..KGGKY.----..EKGKV.TDA.V......DDTNADKQFG...................DEFDAYNDI.KKVTEALVKTMTSLVSEDPS.VGDTINEFLSDMNQLF--ls
Q7RQS5_PLAYO/117-315               .......avvpgspssd---------..---SEIE-EPQNVLTEITIESTENVQITEEELAVCEEIE-ES...........YDEMEEEEEETE-.E.........QIPENFEINIeedeDEEEEEEE...EE...EEVEEEEQ..TSST..E--NPEAGEQ..GSTQT.QESNgtNPESS.TQT.N......TDENGQTIKKgttggaaplinaisndpinAESRNVVES.KQEAKEIMKTLVTMFDDVDV.FDEPVFDFSDDISQFL--i.
W7K323_PLAFO/528-697               ...glgsgalpgtniit---------..--------EEKYSLELIKLTSKDEEDIIKHNEDVREEIEEQQ...........EDIEEDEEELENEgE.........ETKEEDDEE-....KNETNDTE...DT...DDTEDTED..IEEE..NKEKELSNQQ..QSEKK.S---..-----.-IS.K......VDEDSYRILS...................VSYKDNNEV.KNVAESIVKKLFSLFNDNNN.LETIFKGLTEDMTDLFQ-k.
Q8IJ45_PLAF7/571-762               .................ELSSGSSSL..EQHSKEDVKKGCALELVPLSLSDIEQIANESEDVLEEIEEEIntdgeieyiteEEIKEDIEEETE-.E.........DIEEETEEET....EEETEEEA...DE...ETVKEIED..KPEQ..EIKNKSLEEK..QIDKN.TDTS..EKKGF.NNS.E......KDEKARNLIS...................KNYKNYNEL.DKNVHTLVNSIISLLEEGNG.SDSTLNSLSKDITNLFKN..
A5KAV6_PLAVS/951-1139              ...aaekakkaaeesal---------..-------KKKLKVLEIVKKYSKEGYNTVDSDEHVLNEVEEQA...........SEAKEEEEEDDE-.E.........EAEHSLPNDV....EIEDDDDE...GE...EEEKEEEEteVKEE..EDVKEEGHAQ..SSAHQsSVTE.lENQKA.QSQ.EksekplSDSNAQALLE...................DNYKDVVNF.KKMADGLTKNIISTIDGDTD.VLDTLKDFAEDLNQFI--fs
A5KDU7_PLAVS/513-670               .............ppdp---------..-----------NSLQEVNTSEKDKDVSSKEEEVLVEKGVEDD...........AQDGGHDDDTGEG.G.........ETDSANQDDV....SLEYDDEE...VE...----E--E..NEDA..EYSQQITETQ..NGKSN.SPTV..---GL.ESL.I......SDATVHDALA...................EQCKDNVQG.KKEAEAFVNTLLDLLDGSNSaADNAIKNLADDISQFL--lk
Q8IJ48_PLAF7/237-404               .................AWEIGGGAP..TYKPENNKNDNILLEHVKITSWDKEDIIKENEDT--------...........----KREVQETEDtD.........ETEDTDETE-....--ETEDME...DE...NEIVE-DQ..LQEN..EDDEDNVNLE..DINKN.TRNDifEEQIK.LDS.T......QDDKAQKLIS...................NEYKKTEE-.KKSLEDHVNLLFNFLQTNNQ.LDPSLKDLENELTFFLNN..
B3L2C1_PLAKH/525-704               ..............vpp------STS..EHTSNENAAKLNILEEVNITEETKDINPKEEEELVEEEVQED...........LEKEEEEESETEEgG.........ETDSANYDDV....DVEVDDDD...EE...----EQDE..IEDQ..EILQPITETQ..NSQEN.PTEQ..-----.-NN.P......ADVGHKSLITeamv..........hsafaEEYKDNVKD.KKAAEAFVNTLLDLLDGDNStVDDAIKNLANDISQFM--lk
A5KAV3_PLAVS/932-1110              aaeaaekakkaaaesal---------..-------KKKLKVLEIVKKYSKRGYNVVDNDEQVLNEVDEQA...........SEAKE-E--EDE-.D.........EADDSASSDV....--EIEDDE...EE...EEEED-EE..VKEE..EGQAQSSAHQ..NSVAE.LENQkkESQEKsDEP.P......SDNNAQALLS...................DNYKNFTDF.KKKAEDLTKNIINTIDGDAG.VIDTLKDFANDVNQFIL-n.
W7KDK7_PLAFO/184-370               .................GWEFGGGAP..QNGAAEDKKTEYLLEQIKIPSWDRNNIPDENEQVIEDPQEDN...........KDEDEDEETETEN.L.........ETEDDNNEEI....EENEEDDI...DEesvEEKEEEEE..KKEE..EEKKEEKKEE..KKPDN.EITNevKEEQK.YSS.P......SDINAQNLIS...................NKNKKNDET.KKTAENIVKTLVGLFNEKNE.IDSTINNLVQEMIHLFSN..
Q8IJ55_PLAF7/195-353               .................GWEFGGGVP..EHKKEEN-----MLSHLYVSSKDKENISKENDDV--------...........LDEKEEEAEETEE.E.........ELEEKNEEET....--ESEISE...DE...EEEEEEEE..KEEE..NDKKKEQEKE..QSNEN.N---..-----.-DQ.K......KDMEAQNLIS...................KNQNNNEKNvKEAAESIMKTLAGLIKGNNQ.IDSTLKDLVEELSKYFKN..
B3LD32_PLAKH/777-919               ...........agdmed---------..-------------------------------K----ELEEEE...........EEEEEEEDDEEEAvE.........EEEEVKEKEV....ANPTETHD...GE..qEEAKE---..GEEN..GEHPSPSNTT..SESQN.TNVQ..SPEQV.VKP.L......SDSKAQALLT...................DTSKDLVDL.KKKVDQITKNIMNTLDGDTA.VLDTLKDFAKDLNQFI--lt
A5KAV1_PLAVS/739-899               ....siykteyeylkli---------..---------KQDVLEPLKVSTEASDNVFDKNEQV----AQEV...........EDRGSEENDA---.-.........AEEDAAPSDV....EEDEGELE...DE...EEEEEEVE..QLE-..--QPQEQQTD..ASSKD.KGTA..ETQKS.EDV.L......DDEGAHKLLA...................GELNTANKS.NNAENALFKTVFDE-----V.RDDTIQNLKQDVGQFFK-g.
Q8IJ53_PLAF7/262-423               .................GIEFSGGLYfnEKKSTEENKQKNVLESVNLTSWDKEDIVKENEDV--------...........----KDEKDEDD-.E.........EEEEKYENEI....IKQPEDIL...DE...EEVLEEEI..LEEN..K---------..--NDT.VDTSdlEKKNI.PDL.S......NDNNYYSLIY...................KNYKDNDKS.EKTAQTLITALISLLNGKNE.LDATIRRLKHRFMEFFTY..
A5KAV7_PLAVS/742-906               ........ikaaheflk---------..-------TKNQDILEPVEMFSGGTENVTDREEQV-KEEVEEQ...........GDGNNEQAEEAEEvD.........ESESALPNG-....SDGLEDDV...DF...----DVDD..GEEE..E-ENVATNKQ..KGGKY.----..EKGKV.TDA.V......DDTNADKQFG...................DEFDAYNDI.KKVTEALVKTMTSLVSEDPS.VGDTINEFLSDMNQLF--ls
W7JSL9_PLAFO/163-330               .................AWEIGGGAP..TYKPENNKNDNILLEHVKITSWDKEDIIKENEDT--------...........----KREVQETEDtD.........ETEDTDETE-....--ETEDME...DE...NEIVE-DQ..LQEN..EDDEDNVNLE..DINKN.TRNDifEEQIK.LDS.T......QDDKAQKLIS...................NEYKKTEE-.KKSLEDHVNLLFNFLQTNNQ.LDPSLKDLENELTFFLNN..
Q8IJ54_PLAF7/184-370               .................GWEFGGGAP..QNGAAEDKKTEYLLEQIKIPSWDRNNIPDENEQVIEDPQEDN...........KDEDEDEETETEN.L.........ETEDDNNEEI....EENEEDDI...DEesvEEKEEEEE..KKEE..EEKKEEKKEE..KKPDN.EITNevKEEQK.YSS.P......SDINAQNLIS...................NKNKKNDET.KKTAENIVKTLVGLFNEKNE.IDSTINNLVQEMIHLFSN..
A5KAW0_PLAVS/692-851               .........kaaygllk---------..-------TKNQYVLEPLDISPESADNITSKEEQV-KEEMEDQ...........GDEDSNEAEVEEAlP.........NGSGAQEEDV....--NLE-MD...DE...EEVEE---..VEEN..VATNQQTGG-..-----.--KR..EKRNT.NDT.V......DDTNADKQFG...................DEFDTYNDI.KKVTEALVKSMTSLVSDDPS.VGDTINEFLSDMNHLF--ls
W7JS07_PLAFO/187-345               .................GWEFGGGVP..EHKKEEN-----MLSHLYVSSKDKENISKENDDV--------...........LDEKEEEAEETEE.E.........ELEEKNEEET....--ESEISE...DE...EEEEEEEE..KEEE..NDKKKEQEKE..QSNEN.N---..-----.-DQ.K......KDMEAQNLIS...................KNQNNNEKNvKEAAESIMKTLAGLIKGNNQ.IDSTLKDLVEELSKYFKN..
A5KAV8_PLAVS/1062-1242             ...saekaqkaaaesal---------..-------KKKLNVLEIVKKYSKESYNTVDSDEHVLNEVEEQA...........SEEKEEEEEEEE-.A.........EHSVSNEVEI....EDDEEEEE...EE...EEEGEETN..TEGEksEDNSPHSDTE..PQEQN.QSVK..PPEQS.EKT.L......NDSNTQALLS...................DNYKNVANF.KKMADDLTKNIISTIDGDTG.VIDTLKDFAEDLNQFI--fs
B3L6P2_PLAKH/816-960               ................a---------..-------------------------------DDV-EDDVEDD...........NDDDEDEEEEEEN.D.........VVEEEGQVKV....EEKEEVDQstvQE...GELEKANQ..GEET..EENTPPSDTP..PKEQN.SNVQ..SPEQV.VKP.L......SDSKAQALLT...................DNNKNFIDL.KKKVDQITKNIMNTLDGDTT.VLDTLKDFAEDLNQFI--lt
W7K320_PLAFO/571-762               .................ELSSGSSSL..EQHSKEDVKKGCALELVPLSLSDIEQIANESEDVLEEIEEEIntdgeieyiteEEIKEDIEEETE-.E.........DIEEETEEET....EEETEEEA...DE...ETVKEIED..KPEQ..EIKNKSLEEK..QIDKN.TDTS..EKKGF.NNS.E......KDEKARNLIS...................KNYKNYNEL.DKNVHTLVNSIISLLEEGNG.SDSTLNSLSKDITNLFKN..
Q8IJ52_PLAF7/528-697               ...glgsgalpgtniit---------..--------EEKYSLELIKLTSKDEEDIIKHNEDVREEIEEQQ...........EDIEEDEEELENEgE.........ETKEEDDEE-....KNETNDTE...DT...DDTEDTED..IEEE..NKEKELSNQQ..QSEKK.S---..-----.-IS.K......VDEDSYRILS...................VSYKDNNEV.KNVAESIVKKLFSLFNDNNN.LETIFKGLTEDMTDLFQ-k.
A5KAV4_PLAVS/939-1125              .......akkaaaesal---------..-------KKKLNVLEIVKKYSREGYNTVDSDEHVLNEVEEQA...........SEEKEEGEREEEE.EadhpilndvEIDDDDEEEE....EEEEEKEE...EE...TEVKEEED..AKEE..GHAQSSAHQS..SITEL.ENPK.kEYQEK.SDKpP......SDSNAQALLE...................DNYKNFTDF.KKKAEDLTKNIINTIDGDAG.VIETLKDFAKDMNQFIL-n.
A5KAV2_PLAVS/863-1015              .............alir---------..-------TKKQYALEPLEITSEAGYNITEKEEQVKEEIEEQ-...........DDKASEEEEEDT-.Q.........QIDQTQIDEV....DISVDNEE...EE...EGAAE-EQ..IEGE..KD-TPTKE--..-AKEE.Q-TS..GEK--.--I.L......DDKEAHKTLA...................EKFKDSNTA.KTGGVEFLETLISDVGE---.--DTLKNLQQDLHQYFK-g.
Q4Y5Z4_PLACH/208-350               .................---------..-----------------------------------EEEEEED...........DDEDENVVDESVNvI.........ESDAEKQDDN....KEETESEE..dDE..nNDVAE-EA..LNEA..NETNENEKEKvpKESEN.ETTE.kEEDKE.EPT.T......IDSKAKKIIS...................EYYQNMKNI.KNKIKDYVKSAMDLIDGNNG.ISKAFSNLSEDISNFI--lk
#=GC seq_cons                      ....................................cp..hLE.lplsSt-ppslsccsEpV.p-..Ept...........t-tcE-Ec-EsEt.-.........Et--sspp-h....pp-pE-c-...DE...-EhcE.-p..hcEp..ctpppppppp..ptscs.p.sp..p.pth..ss........sDpsApsLlu...................cpaKsssch.KKss-sllKslhshlsssss.lssTl+sLspDlspah....
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