GenomeNet

Database: Pfam
Entry: MetRS-N
LinkDB: MetRS-N
Original site: MetRS-N 
#=GF ID   MetRS-N
#=GF AC   PF09635.5
#=GF DE   MetRS-N binding domain
#=GF AU   Coggill P
#=GF SE   pdb_2hsn
#=GF GA   21.20 21.20;
#=GF TC   21.90 42.10;
#=GF NC   20.60 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16914447
#=GF RT   Structural basis of yeast aminoacyl-tRNA synthetase complex
#=GF RT   formation revealed by crystal structures of two binary
#=GF RT   sub-complexes. 
#=GF RA   Simader H, Hothorn M, Kohler C, Basquin J, Simos G, Suck D; 
#=GF RL   Nucleic Acids Res. 2006;34:3968-3979.
#=GF DR   INTERPRO; IPR018285;
#=GF CC   The MetRS-N domain binds an Arc1-P domain in a tetrameric
#=GF CC   complex resembling a classical GST homo-dimer. Domain-swapping
#=GF CC   between symmetrically related MetRS-N and Arc1p-N domains
#=GF CC   generates a 2:2 tetramer held together by van der Waals forces.
#=GF CC   This domain is necessary for formation of the aminoacyl-tRNA
#=GF CC   synthetase complex necessary for tRNA nuclear export and
#=GF CC   shuttling as part of the translational apparatus. The domain is
#=GF CC   associated with Pfam:PF09334.
#=GF SQ   42
#=GS Q5AK65_CANAL/9-120   AC Q5AK65.1
#=GS A3LNS2_PICST/8-121   AC A3LNS2.1
#=GS H8X953_9ASCO/9-121   AC H8X953.1
#=GS G0VGT4_NAUCC/12-126  AC G0VGT4.1
#=GS E7KNW8_YEASL/11-132  AC E7KNW8.1
#=GS H0GGZ2_9SACH/11-132  AC H0GGZ2.1
#=GS C4R0E2_PICPG/10-104  AC C4R0E2.1
#=GS Q74Z74_ASHGO/11-130  AC Q74Z74.1
#=GS C7GNG8_YEAS2/11-132  AC C7GNG8.1
#=GS G8YT24_PICSO/11-122  AC G8YT24.1
#=GS B9WI14_CANDC/9-120   AC B9WI14.1
#=GS A7TNV8_VANPO/11-132  AC A7TNV8.1
#=GS H2AQ02_KAZAF/11-125  AC H2AQ02.1
#=GS A5E344_LODEL/9-122   AC A5E344.1
#=GS E7NI85_YEASO/11-132  AC E7NI85.1
#=GS H0GVF6_9SACH/11-132  AC H0GVF6.1
#=GS G8BNZ1_TETPH/11-80   AC G8BNZ1.1
#=GS C4Y0R7_CLAL4/7-117   AC C4Y0R7.1
#=GS G8YUH6_PICSO/10-122  AC G8YUH6.1
#=GS C8Z9F6_YEAS8/11-132  AC C8Z9F6.1
#=GS A5DIE2_PICGU/10-123  AC A5DIE2.2
#=GS C5MJ30_CANTT/9-120   AC C5MJ30.1
#=GS SYMC_YEAST/11-132    AC P00958.4
#=GS SYMC_YEAST/11-132    DR PDB; 2HSN A; 13-134;
#=GS A6ZUS2_YEAS7/11-132  AC A6ZUS2.1
#=GS G2WEY9_YEASK/11-132  AC G2WEY9.1
#=GS F2QTA6_PICP7/10-104  AC F2QTA6.1
#=GS B5RUW5_DEBHA/10-123  AC B5RUW5.1
#=GS G0W8A8_NAUDC/11-129  AC G0W8A8.1
#=GS G8JSR6_ERECY/11-132  AC G8JSR6.1
#=GS C5DD77_LACTC/11-132  AC C5DD77.1
#=GS B3LHX8_YEAS1/11-132  AC B3LHX8.1
#=GS Q6CXB8_KLULA/38-158  AC Q6CXB8.1
#=GS C4YRX9_CANAW/9-120   AC C4YRX9.1
#=GS B5VJK7_YEAS6/11-132  AC B5VJK7.1
#=GS G8B6J5_CANPC/9-122   AC G8B6J5.1
#=GS G3ASH9_SPAPN/10-121  AC G3ASH9.1
#=GS G8C088_TETPH/11-132  AC G8C088.1
#=GS G8ZYF8_TORDC/11-131  AC G8ZYF8.1
#=GS E7RAH7_PICAD/10-128  AC E7RAH7.1
#=GS G3B4G5_CANTC/10-122  AC G3B4G5.1
#=GS Q6FTV8_CANGA/11-130  AC Q6FTV8.1
#=GS C5DVL1_ZYGRC/11-131  AC C5DVL1.1
Q5AK65_CANAL/9-120              .......KGNTL-LALTNNLKLSIALAAFE.PKV..ELTLN.EVE..SN...LSLKDKKSG.FELIEPNAIVKYLAKDFTT.TEAIKFE------EQVLYSa..iKSNKKDELAKITD--LPKFA.---KEELTPSQIIVFASLY.....................................................
A3LNS2_PICST/8-121              ..kkstl------EALATNLKLSIASSAFQ.KQV..SVSVN.EDA.dST...ALLVDKKAG.FELSEPNAVVKYLSSDFTDaSGAIAFE------ESQLYPa..lKANSADKISQIAT---PAYF.--EKAEITAAQIILFSALY.....................................................
H8X953_9ASCO/9-121              .......KDKTL-LALVNNLKLSIAAIVYD.PKLvvKLPED.DDH..IG...VLLKDKKTG.FELFEPNAIVKYLAKNYTT.DEHIKIE--EKELHQVLLT....N--KKENLEQVKI------T.TPSKVELNPSQIILFSSLY.....................................................
G0VGT4_NAUCC/12-126             .......KDHSHQVTLANNLKVALAIEYAT.KDL..KLTID.EET..DE...TLL-AVSDS.FHLVDANAIVRYALNDFND.QDSGEYE-----LQSTLYE....NEAPADID-NIVTNTISKYL.TDIKEPVSATKLITLANAF.....................................................
E7KNW8_YEASL/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
H0GGZ2_9SACH/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
C4R0E2_PICPG/10-104             ...gsgl------LDLSDNLKLSIATSLFS.KAC..VLQDK.DVT..ET...VLL-KTKSG.FELFEPNAIVRYLASSRI-.-------------------....--------------------.-------------------gldafkrsnlshfeevvlynvlksgksltepllel..................
Q74Z74_ASHGO/11-130             .......KDHSYGFQLANNIKLALAQVLAP.AGC..TLKVC.ENE..G-...PQL-TSGSG.FRLFDANAILRFVLNDYEA.SGSDECQYAQASLEHMLHR....SEMVPDYVTTAANKSLEHYL.VSMEEPLSATRLITFANTY.....................................................
C7GNG8_YEAS2/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTATDLILFANVY.....................................................
G8YT24_PICSO/11-122             .....gt----SLLALSNNLKVAIATKLYK.PDL..DFSNK.EDE..SG...LKLRNNADG.FELVEANSIVKYLSNDFST.SEDLAFE------ETVLFHa..lKSGKKDEIEGALK----SRS.FSFGKDVSASLIILFATVY.....................................................
B9WI14_CANDC/9-120              .......KGNTL-LALANNLKLSIALAAFQ.PKV..ELALN.EVE..SN...LSLKDKKSG.FELVEPNAIVKYLANDFNT.TEAIQFE------EEVLYAa..iKSNKKDEIAKITG--LPKFA.---KEELTPSQIIVFASLY.....................................................
A7TNV8_VANPO/11-132             .......KKHSRFLATANNLKLALALEYTT.GDL..KIAVD.DDS..TG...PLLMGPNGS.FHLVDANAILRYAMDDFVG.SQSKEYLDSLKKIESLFYG...vDTLPIDQIDSLTA-TLASAS.DFVAEPVDATKLIIFANAF.....................................................
H2AQ02_KAZAF/11-125             .......KTHSHELTLANNLKIALAIQFAT.KDF..KFKIN.EDE..ST...PKL-SIGDS.FNLIDTNSILRYAMNDFEG.QDSEQYQFALCTLQPQLYK....STDSAEAVTKAAT-----FL.QDLSTP-SASQLIILANSY.....................................................
A5E344_LODEL/9-122              krsslnn--------FVKNLKLSIAAAVYK.PDL..KVELS.PETeiKD...VLLRDKKNPaFQLTEPNAIVKYLADDFTN.EELIKFE------ETVLYKa..lISNKRESLNDIEL-KLPE--.---SVKLKPAQIILFASVY.....................................................
E7NI85_YEASO/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTATDLILFANVY.....................................................
H0GVF6_9SACH/11-132             .......KKHPAHLQLANNLKIALALGLAN.KNL..KLEVN.DDN..AA...MELCSTKEA.FTLFDANAILRYIMDDFED.QSSDKYQFALASLQNLLYH....KELPGQHVEVLTNKAFENYL.AELKEPLTATDLILFANV-c....................................................
G8BNZ1_TETPH/11-80              .......KEHPQELLIANNLKLTIALEFKT.KDL..KLSVN.EDL..KT...PSL-SINDQ.FRLFNTDAILRYALNDFEG.LN-----------------....--------------------.-------------------vevss................................................
C4Y0R7_CLAL4/7-117              ....rgs---TL-LALVNNLKVSIAAAAFA.PEA..--QVE.PAD..SG...LLFRDSKSG.FELAEANAIVKYLAKDFAP.SPVFAVE------ENEIYS....-ALKSQSREKAVD-ALSKLS.VPESTELSAANIVLYAAAY.....................................................
G8YUH6_PICSO/10-122             ....cgt----SLLALSNNLKVAIATKLYK.PDL..DFQNK.EDE..SG...LKLRNNADG.FELLEANSIVKYLSNDFST.SEDLEFE------ETVLFSa..lKSGKKDEIEGALK--SRNFS.--FGKDVSASLIILFASVY.....................................................
C8Z9F6_YEAS8/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
A5DIE2_PICGU/10-123             ...rgsd----L-LALASNLKVCIGALVFQ.GGI..QVELG.EDE..SH...TGLKDSKTG.FRLLESNAIVKYLAKDFKR.TEAIEFE------ETKLYQa..lKSNQKEQIMALSD-LLPDFA.--DNQEITAEKVIIFSALY.....................................................
C5MJ30_CANTT/9-120              ......k-GSSL-LALSNNLKLAIALSSYQ.PKL..SLTLN.ETE..SQ...LSLKDKKSG.FELIEPNAIVKYLANDFTN.DKAIKFE------EQVVYPv..lKSNKSDGILKISD--LPSFE.---KAEITPAQIILFSSLY.....................................................
SYMC_YEAST/11-132               .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
#=GR SYMC_YEAST/11-132    SS    .......SS--HHHHHHHHHHHHHHHHH--.STT..--EE-.SS-..-S...--EEE-S--.S----HHHHHHHHTT--TT.TTSHHHHHHHHHTTTGGGS....SS--HHHHHHHHHHHHHHT-.S---SS--HHHHHHHHHHH.....................................................
A6ZUS2_YEAS7/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTATDLILFANVY.....................................................
G2WEY9_YEASK/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KLEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTATDLILFANVY.....................................................
F2QTA6_PICP7/10-104             ...gsgl------LDLSDNLKLSIATSLFS.KAC..VLQDK.DVT..ET...VLL-KTKSG.FELFEPNAIVRYLASSRI-.-------------------....--------------------.-------------------gldafkrsnlshfeevvlynvlksgksltepllel..................
B5RUW5_DEBHA/10-123             ......k-GSSL-LTLASNLKLSLVSAIYQ.PKL..SVSLS.ENE..SS...LSLIDKKSG.FELSEPNAIVKYLANDFNK.DKLLEFE------ETSLYKa..aKSNKKDAIVQAINESSIKL-.--EKAETSTSQIILFAAVY.....................................................
G0W8A8_NAUDC/11-129             .......KDHSHAISFANNLKIALAIEYAT.KDL..KLTIN.DDS..NI...AQL-VVSDS.YQLFNPNAILRYALNDFTD.QESEANQFAVTIVEKALIS....SETSSKE---VVTKTLEQYLpYPIEEPVSATKLILLAD--il...................................................
G8JSR6_ERECY/11-132             ......k-TQLSGLQLATNIKLALALQLGDiSAS..KIAVN.DEA..VG...PQL-FGPPL.FRLFDSNAILRYVMDDFEG.LDSEEGLFALSSVEAVLHH....KSIQKEHVESIASKSLDSYL.LSLQEPLSATKLITFANTY.....................................................
C5DD77_LACTC/11-132             .......KDHSYALQLANNIKLALAQELAG.KEI..KISVN.DES..VK...PELTVASTD.FRLFNTNAILRYVLNDFEG.LESSETHFAVSSLEAMLYH....PSAPQEHVKENVSKALENYL.QELREPFCATNLITFANAY.....................................................
B3LHX8_YEAS1/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
Q6CXB8_KLULA/38-158             .......KGHTSALQLANNIKLAYAL-LSS.GNL..KLEEN.KDV..LI...PQLVIDSTG.FRLFDANAILRYVLNDFEE.EESNEYNFAVSSLEAFASH....KDPIKEHLAEAVQKSLDNYL.TSVEEPLSATRIVIFANTY.....................................................
C4YRX9_CANAW/9-120              .......KGNTL-LALTNNLKLSIALAAFE.PKV..ELTLN.EVE..SN...LSLKDKKSG.FELIEPNAIVKYLAKDFTT.TEAIKFE------EQVLYSa..iKSNKKDELAKITD--LPKFA.---KEELTPSQIIVFASLY.....................................................
B5VJK7_YEAS6/11-132             .......KKHPAHLQLANNLKIALALEYAS.KNL..KPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMDDFEG.QTSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VELKEPLTTTDLILFANVY.....................................................
G8B6J5_CANPC/9-122              .......KDKTL-LALVNNLKLSIAAAAYD.PKL..VVKLP.EDS..DHqigVLLKDKKTG.FELFEPNAIVKYLAKNYTI.DEHIKIE-EKELHQAVLTN....RKESLEQVQVSTP-------.--SKVEVNPSQIILFSSLY.....................................................
G3ASH9_SPAPN/10-121             ......k-GSSL-LTLSTNLKLCIATSAFQ.PKL..SVS-N.DTP..SD...ALLKDKKSD.FALHEVNAVVKYLANDFST.NEAIQFE------ETQLYKa..lKSNKKEKLTSAVSGSIT-FT.---KAELTPAQIILFASVY.....................................................
G8C088_TETPH/11-132             .......KHDTNLLKLANNLKLLLGVEYNN.RDF..EIEMD.EDC..QI...PRL--MSDT.VCLYEPNAILRYLINDYHG.IEDEEYERFVKKFDNLCHKefgnKEDMQSELQ--MEVAADKYL.QNLENNVTANDLILFADVY.....................................................
G8ZYF8_TORDC/11-131             .......KGRQQALSLSNNLKITLALEYAS.KDF..KIAVN.EEL..EG...PQL-INGDN.LRLIDTDAILRYILNDFEG.QRSDEYHYALSSLESLFQK....NDIPEQHVEACVSKSLDNYL.LSLEEPLSATRLITFANTY.....................................................
E7RAH7_PICAD/10-128             ....dgs-----VLSLVSNLKVSIAAAVFS.PGL..QLEVDtEGK..SK...LALQVSNSG.FELIEPNAIVKYLAATKNG.NNS----------------....--------------------.-------------------vfgnhelidkdekilypalksnqidlsilsqigsipsanaedvsqiiifssly
G3B4G5_CANTC/10-122             .......KGNST-LSLVNNLKVTVAAKAAD.GNL..KVNS-.EDD..SN...LKLLNKATG.FELTEPNAIVKYLINDFDS.ASILSIE----ETAVYSAH....KSGKKEEVISFIKSESSPFT.---KAELTASQIILFSSVY.....................................................
Q6FTV8_CANGA/11-130             .......KGRDAKVVLANNLKIALAIELA-.KGL..KLSIN.EDR..SE...PLL--TAGE.LVLRDANAILRYALDDFEG.IHSEQYHYALSSVEAYLYH....QQSSEEHATELVNKMIDNYLkLDKDSKLDAVTLISFANAY.....................................................
C5DVL1_ZYGRC/11-131             .......KGHAQAVTFANNFKIALGLEYAA.KGT..KTTVN.EDN..VG...PAL-IQGES.FRLFDSNAILRYLLNDFAP.QQVDEYEYALSSLEHLLHQ....KQVPKEHADECVDKALNNYL.TSLEEPLSATRLISFVNAY.....................................................
#=GC SS_cons                    .......SS--HHHHHHHHHHHHHHHHH--.STT..--EE-.SS-..-S...--EEE-S--.S----HHHHHHHHTT--TT.TTSHHHHHHHHHTTTGGGS....SS--HHHHHHHHHHHHHHT-.S---SS--HHHHHHHHHHH.....................................................
#=GC seq_cons                   .......Ktpsh.LpLANNLKlulAlphhs.tsL..clpls.-Ds..us...hpLhsspss.FpLh-sNAIlRYlhsDFps.ppu.cap.....hpshLYp....Kp..ppclp.hss.tltpah....cp.losoplIlFAslY.....................................................
//
DBGET integrated database retrieval system