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Database: Pfam
Entry: MetRS-N
LinkDB: MetRS-N
Original site: MetRS-N 
#=GF ID   MetRS-N
#=GF AC   PF09635.8
#=GF DE   MetRS-N binding domain
#=GF AU   Coggill P
#=GF SE   pdb_2hsn
#=GF GA   23.30 23.30;
#=GF TC   24.50 24.80;
#=GF NC   22.00 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16914447
#=GF RT   Structural basis of yeast aminoacyl-tRNA synthetase complex
#=GF RT   formation revealed by crystal structures of two binary
#=GF RT   sub-complexes. 
#=GF RA   Simader H, Hothorn M, Kohler C, Basquin J, Simos G, Suck D; 
#=GF RL   Nucleic Acids Res. 2006;34:3968-3979.
#=GF DR   INTERPRO; IPR018285;
#=GF CC   The MetRS-N domain binds an Arc1-P domain in a tetrameric
#=GF CC   complex resembling a classical GST homo-dimer. Domain-swapping
#=GF CC   between symmetrically related MetRS-N and Arc1p-N domains
#=GF CC   generates a 2:2 tetramer held together by van der Waals forces.
#=GF CC   This domain is necessary for formation of the aminoacyl-tRNA
#=GF CC   synthetase complex necessary for tRNA nuclear export and
#=GF CC   shuttling as part of the translational apparatus. The domain is
#=GF CC   associated with Pfam:PF09334.
#=GF SQ   43
#=GS Q5AK65_CANAL/9-120       AC Q5AK65.1
#=GS A3LNS2_PICST/8-121       AC A3LNS2.1
#=GS W1QAR5_OGAPD/10-128      AC W1QAR5.1
#=GS G0VGT4_NAUCC/12-126      AC G0VGT4.1
#=GS E7KNW8_YEASL/11-132      AC E7KNW8.1
#=GS C4R0E2_PICPG/10-104      AC C4R0E2.1
#=GS Q74Z74_ASHGO/11-130      AC Q74Z74.1
#=GS G8YT24_PICSO/11-122      AC G8YT24.1
#=GS I2H267_TETBL/11-131      AC I2H267.1
#=GS R4XDJ8_TAPDE/12-135      AC R4XDJ8.1
#=GS M3IJN0_CANMX/9-121       AC M3IJN0.1
#=GS W6MSW4_9ASCO/9-85        AC W6MSW4.1
#=GS A7TNV8_VANPO/11-132      AC A7TNV8.1
#=GS H2AQ02_KAZAF/11-125      AC H2AQ02.1
#=GS A5E344_LODEL/9-122       AC A5E344.1
#=GS J7S704_KAZNA/11-130      AC J7S704.1
#=GS E7NI85_YEASO/11-132      AC E7NI85.1
#=GS A0A0F4X9E1_HANUV/14-120  AC A0A0F4X9E1.1
#=GS G8BNZ1_TETPH/11-80       AC G8BNZ1.1
#=GS C4Y0R7_CLAL4/7-117       AC C4Y0R7.1
#=GS G8YUH6_PICSO/10-122      AC G8YUH6.1
#=GS K0KGG6_WICCF/3-89        AC K0KGG6.1
#=GS A5DIE2_PICGU/10-123      AC A5DIE2.2
#=GS C5MJ30_CANTT/9-120       AC C5MJ30.1
#=GS SYMC_YEAST/11-132        AC P00958.4
#=GS SYMC_YEAST/11-132        DR PDB; 2HSN A; 13-134;
#=GS A0A0L0NXQ2_9ASCO/9-120   AC A0A0L0NXQ2.1
#=GS B5RUW5_DEBHA/10-123      AC B5RUW5.1
#=GS G0W8A8_NAUDC/11-129      AC G0W8A8.1
#=GS A0A0H5CB96_CYBJA/8-124   AC A0A0H5CB96.1
#=GS G8JSR6_ERECY/11-132      AC G8JSR6.1
#=GS A0A0A8L156_9SACH/12-132  AC A0A0A8L156.1
#=GS J8Q7R6_SACAR/11-132      AC J8Q7R6.1
#=GS C5DD77_LACTC/11-132      AC C5DD77.1
#=GS J5PNA7_SACK1/11-132      AC J5PNA7.1
#=GS Q6CXB8_KLULA/38-158      AC Q6CXB8.1
#=GS I2JWJ1_DEKBR/10-129      AC I2JWJ1.2
#=GS G8B6J5_CANPC/9-122       AC G8B6J5.1
#=GS G8C088_TETPH/11-132      AC G8C088.1
#=GS G3ASH9_SPAPN/10-121      AC G3ASH9.1
#=GS G8ZYF8_TORDC/11-131      AC G8ZYF8.1
#=GS G3B4G5_CANTC/10-122      AC G3B4G5.1
#=GS Q6FTV8_CANGA/11-130      AC Q6FTV8.1
#=GS C5DVL1_ZYGRC/11-131      AC C5DVL1.1
Q5AK65_CANAL/9-120                  ................KGNTL-LALTNNLKLSIALAAFE.PKVELTLN.EVE..SN...L.SLKDKKSG.FELIEPNAIVKYLAK.....DFTT.T.EAIKFE------EQVLYSa..iKSNKKDEL....AKITD--LPKFA.--.-KEELTPSQIIVFASLY.....................................................
A3LNS2_PICST/8-121                  ...........kkstl------EALATNLKLSIASSAFQ.KQVSVSVN.EDA.dST...A.LLVDKKAG.FELSEPNAVVKYLSS.....DFTDaS.GAIAFE------ESQLYPa..lKANSADKI....SQIAT---PAYF.--.EKAEITAAQIILFSALY.....................................................
W1QAR5_OGAPD/10-128                 .............dgs-----VLSLVSNLKVSIAAAVFS.PGLQLEVDtEGK..SK...L.ALQVSNSG.FELIEPNAIVKYLAA.....TKNG.N.NS----------------....--------....------------.--.-----------------vfgnhelidkdekilypalksnqidlsilsqigsipsanaedvsqiiifssly
G0VGT4_NAUCC/12-126                 ................KDHSHQVTLANNLKVALAIEYAT.KDLKLTID.EET..DE...T.LL-AVSDS.FHLVDANAIVRYALN.....DFND.Q.DSGEYE-----LQSTLYE....NEAPADID....-NIVTNTISKYL.TD.IKEPVSATKLITLANAF.....................................................
E7KNW8_YEASL/11-132                 ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...M.ELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHV....EVLTNKAIENYL.VE.LKEPLTTTDLILFANVY.....................................................
C4R0E2_PICPG/10-104                 ............gsgl------LDLSDNLKLSIATSLFS.KACVLQDK.DVT..ET...V.LL-KTKSG.FELFEPNAIVRYLAS.....SRI-.-.------------------....--------....------------.--.-----------------gldafkrsnlshfeevvlynvlksgksltepllel..................
Q74Z74_ASHGO/11-130                 ................KDHSYGFQLANNIKLALAQVLAP.AGCTLKVC.ENE..G-...P.QL-TSGSG.FRLFDANAILRFVLN.....DYEA.S.GSDECQYAQASLEHMLHR....SEMVPDYV....TTAANKSLEHYL.VS.MEEPLSATRLITFANTY.....................................................
G8YT24_PICSO/11-122                 ..............gt----SLLALSNNLKVAIATKLYK.PDLDFSNK.EDE..SG...L.KLRNNADG.FELVEANSIVKYLSN.....DFST.S.EDLAFE------ETVLFHa..lKSGKKDEI....EGALK----SRS.FS.FGKDVSASLIILFATVY.....................................................
I2H267_TETBL/11-131                 ................KNHSQGLTYANNLKLALAQQFAS.KGTKIEID.TEA..RQ...L.QL-TKGDN.LRLVSADAILRYIMN.....DFSG.Q.DSDEYDFSLASLESLLYH....TSPPSNHI....DQCVEKALDNYL.TS.LSEPLTATRLITYANA-s....................................................
R4XDJ8_TAPDE/12-135                 ..........sarast--------FTDALKVLIAVECFH.AEAQIATG.TTD..DK...V.VLELPKEH.KSLFESNAIVRYLASlsyplDAQG.I.ESSLIEWEETFLSSNLIA....DENVQDKT....LSSADSVVGRA-.GF.VKGQINASQIVLFSSLY.....................................................
M3IJN0_CANMX/9-121                  .............kgg---SL-LSLANNLKLAIAISVFH.PELKLVLD.ESD..SK...L.VLKDKKSG.FELIEANAIVKYLAN.....DFTS.S.DAIDFE------ESVLYPa..vKSNKKDEV....SKVLS-QLPTFG.--.-KTELTPSQIILFASVY.....................................................
W6MSW4_9ASCO/9-85                   ..............kg--NNA-KAFSSNLKLNLAVAAYA.AQLKISVD.ADG..SK...PfLLHENKTN.FTLIEPNAVVQYLAA.....----.-.------------------....--------....------------.--.-----------------strpdafsdteavkter....................................
A7TNV8_VANPO/11-132                 ................KKHSRFLATANNLKLALALEYTT.GDLKIAVD.DDS..TG...P.LLMGPNGS.FHLVDANAILRYAMD.....DFVG.S.QSKEYLDSLKKIESLFYG...vDTLPIDQI....DSLTA-TLASAS.DF.VAEPVDATKLIIFANAF.....................................................
H2AQ02_KAZAF/11-125                 ................KTHSHELTLANNLKIALAIQFAT.KDFKFKIN.EDE..ST...P.KL-SIGDS.FNLIDTNSILRYAMN.....DFEG.Q.DSEQYQFALCTLQPQLYK....STDSAEAV....TKAAT-----FL.QD.LSTP-SASQLIILANSY.....................................................
A5E344_LODEL/9-122                  .........krsslnn--------FVKNLKLSIAAAVYK.PDLKVELS.PETeiKD...V.LLRDKKNPaFQLTEPNAIVKYLAD.....DFTN.E.ELIKFE------ETVLYKa..lISNKRESL....NDIEL-KLPE--.--.-SVKLKPAQIILFASVY.....................................................
J7S704_KAZNA/11-130                 ................KNHSAKLQLANNLKLALAVEFAT.KDLKIKIN.DTV..DS...P.SL--TTDK.VHLFDADAILRYAMD.....QFSG.AfTSESFD-SLSKLEPALYK....EELTTHDK....EHAVH-ALKNYL.VSnLKDTDSATKLITFANV-a....................................................
E7NI85_YEASO/11-132                 ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...M.ELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHV....EVLTNKAIENYL.VE.LKEPLTATDLILFANVY.....................................................
A0A0F4X9E1_HANUV/14-120             .............kne-----KVLRAYNLKVILASKLI-.SKSEVSTD.ASF..LT...P.GLLNSTTG.FSLFNANSILKYAFK.....NYDV.S.V----E--ISDLEKALIS...gTDVSEEQL....TNLLEK------.--.-----------------kegenafksvsnwilian...................................
G8BNZ1_TETPH/11-80                  ................KEHPQELLIANNLKLTIALEFKT.KDLKLSVN.EDL..KT...P.SL-SINDQ.FRLFNTDAILRYALN.....DFEG.L.N-----------------....--------....------------.--.-----------------vevss................................................
C4Y0R7_CLAL4/7-117                  .............rgs---TL-LALVNNLKVSIAAAAFA.PEA--QVE.PAD..SG...L.LFRDSKSG.FELAEANAIVKYLAK.....DFAP.S.PVFAVE------ENEIYS....-ALKSQSR....EKAVD-ALSKLS.VP.ESTELSAANIVLYAAAY.....................................................
G8YUH6_PICSO/10-122                 .............cgt----SLLALSNNLKVAIATKLYK.PDLDFQNK.EDE..SG...L.KLRNNADG.FELLEANSIVKYLSN.....DFST.S.EDLEFE------ETVLFSa..lKSGKKDEI....EGALK--SRNFS.--.FGKDVSASLIILFASVY.....................................................
K0KGG6_WICCF/3-89                   sahvaqnvakfsspvy-----------------------.--------.---..--...-.----GKDG.FELSEPNAIVKYLAN.....DFTQ.T.SEIDYE------EEILHV....LLNSGKSD....ESILTKSPATKL.--.--EKLTASSIILFASTF.....................................................
A5DIE2_PICGU/10-123                 ............rgsd----L-LALASNLKVCIGALVFQ.GGIQVELG.EDE..SH...T.GLKDSKTG.FRLLESNAIVKYLAK.....DFKR.T.EAIEFE------ETKLYQa..lKSNQKEQI....MALSD-LLPDFA.--.DNQEITAEKVIIFSALY.....................................................
C5MJ30_CANTT/9-120                  ...............k-GSSL-LALSNNLKLAIALSSYQ.PKLSLTLN.ETE..SQ...L.SLKDKKSG.FELIEPNAIVKYLAN.....DFTN.D.KAIKFE------EQVVYPv..lKSNKSDGI....LKISD--LPSFE.--.-KAEITPAQIILFSSLY.....................................................
SYMC_YEAST/11-132                   ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...M.ELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHV....EVLTNKAIENYL.VE.LKEPLTTTDLILFANVY.....................................................
#=GR SYMC_YEAST/11-132        SS    ................SS--HHHHHHHHHHHHHHHHH--.STT--EE-.SS-..-S...-.-EEE-S--.S----HHHHHHHHTT.....--TT.T.TSHHHHHHHHHTTTGGGS....SS--HHHH....HHHHHHHHHHT-.S-.--SS--HHHHHHHHHHH.....................................................
A0A0L0NXQ2_9ASCO/9-120              ...........kgkgf------LAQANNVKVAVALALAT.PNVEISRS.DDS..S-...L.QLKEVKSA.FELVEPNAIVKYITG.....DFSN.G.VNILTE------ETDVYQa..lKSGKK-EL....AVEALKKLETPQ.--.DTKELS-ANIIVFGAVY.....................................................
B5RUW5_DEBHA/10-123                 ...............k-GSSL-LTLASNLKLSLVSAIYQ.PKLSVSLS.ENE..SS...L.SLIDKKSG.FELSEPNAIVKYLAN.....DFNK.D.KLLEFE------ETSLYKa..aKSNKKDAI....VQAINESSIKL-.--.EKAETSTSQIILFAAVY.....................................................
G0W8A8_NAUDC/11-129                 ................KDHSHAISFANNLKIALAIEYAT.KDLKLTIN.DDS..NI...A.QL-VVSDS.YQLFNPNAILRYALN.....DFTD.Q.ESEANQFAVTIVEKALIS....SETSSKE-....--VVTKTLEQYLpYP.IEEPVSATKLILLAD--il...................................................
A0A0H5CB96_CYBJA/8-124              ..........dkskgl------VALSNNLKLAIASKVY-.---SVKIE.QEE..GK...F.GLEDTEKG.FQLIEPNAIVKYLAR.....EFAQ.S.QEIEYE--ESTLFPLLSK....NQGSKLSLsfamTHITPSAIILFA.--.TAYALDPTQFPEFA---sl...................................................
G8JSR6_ERECY/11-132                 ...............k-TQLSGLQLATNIKLALALQLGDiSASKIAVN.DEA..VG...P.QL-FGPPL.FRLFDSNAILRYVMD.....DFEG.L.DSEEGLFALSSVEAVLHH....KSIQKEHV....ESIASKSLDSYL.LS.LQEPLSATKLITFANTY.....................................................
A0A0A8L156_9SACH/12-132             ................KGQTSALQLANNIKLAYAL-LSS.GNLKLEEN.KDV..SV...P.QLVIGATG.YRLFDANAILRYTLN.....DFES.E.ESDEYNFALSSLESLASH....KDPNQEHV....AESVRKSLDNYL.SS.VTAPLCATKIITFANTY.....................................................
J8Q7R6_SACAR/11-132                 ................KQHPTHLQLANNLKIALALEFTG.EKLKLEVD.DDS..TT...M.ELHSAKEP.FTLFDANAILRYVMD.....DFED.Q.SSDKYQFALASLQNLLYH....KELPKQHV....EVLTIKAIENYL.TE.LREPLTATDLILFANIY.....................................................
C5DD77_LACTC/11-132                 ................KDHSYALQLANNIKLALAQELAG.KEIKISVN.DES..VK...P.ELTVASTD.FRLFNTNAILRYVLN.....DFEG.L.ESSETHFAVSSLEAMLYH....PSAPQEHV....KENVSKALENYL.QE.LREPFCATNLITFANAY.....................................................
J5PNA7_SACK1/11-132                 ................KKHPAHLQLANNLKIALALGLAN.KNLKLEVN.DDN..AA...M.ELCSTKEA.FTLFDANAILRYIMD.....DFED.Q.SSDKYQFALASLQNLLYH....KELPGQHV....EVLTNKAFENYL.AE.LKEPLTATDLILFANVY.....................................................
Q6CXB8_KLULA/38-158                 ................KGHTSALQLANNIKLAYAL-LSS.GNLKLEEN.KDV..LI...P.QLVIDSTG.FRLFDANAILRYVLN.....DFEE.E.ESNEYNFAVSSLEAFASH....KDPIKEHL....AEAVQKSLDNYL.TS.VEEPLSATRIVIFANTY.....................................................
I2JWJ1_DEKBR/10-129                 ............kgpk-----SVSFVNNLKVELASTIFX.PKLKFADD.SDR..EEn.fL.ELXDKKSG.FTLVEPNAIVKYLAA.....TSKN.G.SKDXFK--ADPLEATLN-....--------....------------.--.-----------------kiaalgskaldgidfekfdftsnantnsviqilayssly..............
G8B6J5_CANPC/9-122                  ................KDKTL-LALVNNLKLSIAAAAYD.PKLVVKLP.EDS..DHqigV.LLKDKKTG.FELFEPNAIVKYLAK.....NYTI.D.EHIKIE-EKELHQAVLTN....RKESLEQV....QVSTP-------.--.SKVEVNPSQIILFSSLY.....................................................
G8C088_TETPH/11-132                 ................KHDTNLLKLANNLKLLLGVEYNN.RDFEIEMD.EDC..QI...P.RL--MSDT.VCLYEPNAILRYLIN.....DYHG.I.EDEEYERFVKKFDNLCHKefgnKEDMQSEL....Q--MEVAADKYL.QN.LENNVTANDLILFADVY.....................................................
G3ASH9_SPAPN/10-121                 ...............k-GSSL-LTLSTNLKLCIATSAFQ.PKLSVS-N.DTP..SD...A.LLKDKKSD.FALHEVNAVVKYLAN.....DFST.N.EAIQFE------ETQLYKa..lKSNKKEKL....TSAVSGSIT-FT.--.-KAELTPAQIILFASVY.....................................................
G8ZYF8_TORDC/11-131                 ................KGRQQALSLSNNLKITLALEYAS.KDFKIAVN.EEL..EG...P.QL-INGDN.LRLIDTDAILRYILN.....DFEG.Q.RSDEYHYALSSLESLFQK....NDIPEQHV....EACVSKSLDNYL.LS.LEEPLSATRLITFANTY.....................................................
G3B4G5_CANTC/10-122                 ................KGNST-LSLVNNLKVTVAAKAAD.GNLKVNS-.EDD..SN...L.KLLNKATG.FELTEPNAIVKYLIN.....DFDS.A.SILSIE----ETAVYSAH....KSGKKEEV....ISFIKSESSPFT.--.-KAELTASQIILFSSVY.....................................................
Q6FTV8_CANGA/11-130                 ................KGRDAKVVLANNLKIALAIELA-.KGLKLSIN.EDR..SE...P.LL--TAGE.LVLRDANAILRYALD.....DFEG.I.HSEQYHYALSSVEAYLYH....QQSSEEHA....TELVNKMIDNYLkLD.KDSKLDAVTLISFANAY.....................................................
C5DVL1_ZYGRC/11-131                 ................KGHAQAVTFANNFKIALGLEYAA.KGTKTTVN.EDN..VG...P.AL-IQGES.FRLFDSNAILRYLLN.....DFAP.Q.QVDEYEYALSSLEHLLHQ....KQVPKEHA....DECVDKALNNYL.TS.LEEPLSATRLISFVNAY.....................................................
#=GC SS_cons                        ................SS--HHHHHHHHHHHHHHHHH--.STT--EE-.SS-..-S...-.-EEE-S--.S----HHHHHHHHTT.....--TT.T.TSHHHHHHHHHTTTGGGS....SS--HHHH....HHHHHHHHHHT-.S-.--SS--HHHHHHHHHHH.....................................................
#=GC seq_cons                       .................tps..LsLANNLKlulAhphhs.tslclpls.--s..st...h.tL.sspsu.FcLh-sNAIl+Ylhs.....DFps.p.pu.cac.....hEshLap....pps.pcpl....pthss.tltpah.....pp.loAoplIlFAssY.....................................................
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