GenomeNet

Database: Pfam
Entry: MetRS-N
LinkDB: MetRS-N
Original site: MetRS-N 
#=GF ID   MetRS-N
#=GF AC   PF09635.7
#=GF DE   MetRS-N binding domain
#=GF AU   Coggill P
#=GF SE   pdb_2hsn
#=GF GA   21.20 21.20;
#=GF TC   21.90 23.20;
#=GF NC   20.20 19.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16914447
#=GF RT   Structural basis of yeast aminoacyl-tRNA synthetase complex
#=GF RT   formation revealed by crystal structures of two binary
#=GF RT   sub-complexes. 
#=GF RA   Simader H, Hothorn M, Kohler C, Basquin J, Simos G, Suck D; 
#=GF RL   Nucleic Acids Res. 2006;34:3968-3979.
#=GF DR   INTERPRO; IPR018285;
#=GF CC   The MetRS-N domain binds an Arc1-P domain in a tetrameric
#=GF CC   complex resembling a classical GST homo-dimer. Domain-swapping
#=GF CC   between symmetrically related MetRS-N and Arc1p-N domains
#=GF CC   generates a 2:2 tetramer held together by van der Waals forces.
#=GF CC   This domain is necessary for formation of the aminoacyl-tRNA
#=GF CC   synthetase complex necessary for tRNA nuclear export and
#=GF CC   shuttling as part of the translational apparatus. The domain is
#=GF CC   associated with Pfam:PF09334.
#=GF SQ   39
#=GS Q5AK65_CANAL/9-120   AC Q5AK65.1
#=GS A3LNS2_PICST/8-121   AC A3LNS2.1
#=GS W1QAR5_OGAPD/10-128  AC W1QAR5.1
#=GS G0VGT4_NAUCC/12-126  AC G0VGT4.1
#=GS E7KNW8_YEASL/11-132  AC E7KNW8.1
#=GS C4R0E2_PICPG/10-104  AC C4R0E2.1
#=GS Q74Z74_ASHGO/11-130  AC Q74Z74.1
#=GS G8YT24_PICSO/11-122  AC G8YT24.1
#=GS I2H267_TETBL/11-131  AC I2H267.1
#=GS R4XDJ8_TAPDE/12-135  AC R4XDJ8.1
#=GS M3IJN0_CANMX/9-121   AC M3IJN0.1
#=GS A7TNV8_VANPO/11-132  AC A7TNV8.1
#=GS H2AQ02_KAZAF/11-125  AC H2AQ02.1
#=GS A5E344_LODEL/9-122   AC A5E344.1
#=GS J7S704_KAZNA/11-130  AC J7S704.1
#=GS E7NI85_YEASO/11-132  AC E7NI85.1
#=GS G8BNZ1_TETPH/11-80   AC G8BNZ1.1
#=GS C4Y0R7_CLAL4/7-117   AC C4Y0R7.1
#=GS K0KGG6_WICCF/3-89    AC K0KGG6.1
#=GS G8YUH6_PICSO/10-122  AC G8YUH6.1
#=GS A5DIE2_PICGU/10-123  AC A5DIE2.2
#=GS U4L9B9_PYROM/13-139  AC U4L9B9.1
#=GS C5MJ30_CANTT/9-120   AC C5MJ30.1
#=GS SYMC_YEAST/11-132    AC P00958.4
#=GS SYMC_YEAST/11-132    DR PDB; 2HSN A; 13-134;
#=GS B5RUW5_DEBHA/10-123  AC B5RUW5.1
#=GS G0W8A8_NAUDC/11-129  AC G0W8A8.1
#=GS G8JSR6_ERECY/11-132  AC G8JSR6.1
#=GS J8Q7R6_SACAR/11-132  AC J8Q7R6.1
#=GS C5DD77_LACTC/11-132  AC C5DD77.1
#=GS J5PNA7_SACK1/11-132  AC J5PNA7.1
#=GS Q6CXB8_KLULA/38-158  AC Q6CXB8.1
#=GS C4YRX9_CANAW/9-120   AC C4YRX9.1
#=GS G8B6J5_CANPC/9-122   AC G8B6J5.1
#=GS G3ASH9_SPAPN/10-121  AC G3ASH9.1
#=GS G8C088_TETPH/11-132  AC G8C088.1
#=GS G8ZYF8_TORDC/11-131  AC G8ZYF8.1
#=GS G3B4G5_CANTC/10-122  AC G3B4G5.1
#=GS Q6FTV8_CANGA/11-130  AC Q6FTV8.1
#=GS C5DVL1_ZYGRC/11-131  AC C5DVL1.1
Q5AK65_CANAL/9-120              ................KGNTL-LALTNNLKLSIALAAFE.PKVELTLN.EVE..SN...LSLKDKKSG.FELIEPNAIVKYLAK.....DFTT.T.EAIKFE------EQVLYSa..iKSNKKDELAKITD--LPKFA.--.-KEELTPSQIIVFASLY....................................................................
A3LNS2_PICST/8-121              ...........kkstl------EALATNLKLSIASSAFQ.KQVSVSVN.EDA.dST...ALLVDKKAG.FELSEPNAVVKYLSS.....DFTDaS.GAIAFE------ESQLYPa..lKANSADKISQIAT---PAYF.--.EKAEITAAQIILFSALY....................................................................
W1QAR5_OGAPD/10-128             .............dgs-----VLSLVSNLKVSIAAAVFS.PGLQLEVDtEGK..SK...LALQVSNSG.FELIEPNAIVKYLAA.....TKNG.N.NS----------------....--------------------.--.-----------------vfgnhelidkdekilypalksnqidlsilsqigsipsanaedvsqiiifssly...............
G0VGT4_NAUCC/12-126             ................KDHSHQVTLANNLKVALAIEYAT.KDLKLTID.EET..DE...TLL-AVSDS.FHLVDANAIVRYALN.....DFND.Q.DSGEYE-----LQSTLYE....NEAPADID-NIVTNTISKYL.TD.IKEPVSATKLITLANAF....................................................................
E7KNW8_YEASL/11-132             ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VE.LKEPLTTTDLILFANVY....................................................................
C4R0E2_PICPG/10-104             ............gsgl------LDLSDNLKLSIATSLFS.KACVLQDK.DVT..ET...VLL-KTKSG.FELFEPNAIVRYLAS.....SRI-.-.------------------....--------------------.--.-----------------gldafkrsnlshfeevvlynvlksgksltepllel.................................
Q74Z74_ASHGO/11-130             ................KDHSYGFQLANNIKLALAQVLAP.AGCTLKVC.ENE..G-...PQL-TSGSG.FRLFDANAILRFVLN.....DYEA.S.GSDECQYAQASLEHMLHR....SEMVPDYVTTAANKSLEHYL.VS.MEEPLSATRLITFANTY....................................................................
G8YT24_PICSO/11-122             ..............gt----SLLALSNNLKVAIATKLYK.PDLDFSNK.EDE..SG...LKLRNNADG.FELVEANSIVKYLSN.....DFST.S.EDLAFE------ETVLFHa..lKSGKKDEIEGALK----SRS.FS.FGKDVSASLIILFATVY....................................................................
I2H267_TETBL/11-131             ................KNHSQGLTYANNLKLALAQQFAS.KGTKIEID.TEA..RQ...LQL-TKGDN.LRLVSADAILRYIMN.....DFSG.Q.DSDEYDFSLASLESLLYH....TSPPSNHIDQCVEKALDNYL.TS.LSEPLTATRLITYANA-s...................................................................
R4XDJ8_TAPDE/12-135             ..........sarast--------FTDALKVLIAVECFH.AEAQIATG.TTD..DK...VVLELPKEH.KSLFESNAIVRYLASlsyplDAQG.I.ESSLIEWEETFLSSNLIA....DENVQDKTLSSADSVVGRA-.GF.VKGQINASQIVLFSSLY....................................................................
M3IJN0_CANMX/9-121              .............kgg---SL-LSLANNLKLAIAISVFH.PELKLVLD.ESD..SK...LVLKDKKSG.FELIEANAIVKYLAN.....DFTS.S.DAIDFE------ESVLYPa..vKSNKKDEVSKVLS-QLPTFG.--.-KTELTPSQIILFASVY....................................................................
A7TNV8_VANPO/11-132             ................KKHSRFLATANNLKLALALEYTT.GDLKIAVD.DDS..TG...PLLMGPNGS.FHLVDANAILRYAMD.....DFVG.S.QSKEYLDSLKKIESLFYG...vDTLPIDQIDSLTA-TLASAS.DF.VAEPVDATKLIIFANAF....................................................................
H2AQ02_KAZAF/11-125             ................KTHSHELTLANNLKIALAIQFAT.KDFKFKIN.EDE..ST...PKL-SIGDS.FNLIDTNSILRYAMN.....DFEG.Q.DSEQYQFALCTLQPQLYK....STDSAEAVTKAAT-----FL.QD.LSTP-SASQLIILANSY....................................................................
A5E344_LODEL/9-122              .........krsslnn--------FVKNLKLSIAAAVYK.PDLKVELS.PETeiKD...VLLRDKKNPaFQLTEPNAIVKYLAD.....DFTN.E.ELIKFE------ETVLYKa..lISNKRESLNDIEL-KLPE--.--.-SVKLKPAQIILFASVY....................................................................
J7S704_KAZNA/11-130             ................KNHSAKLQLANNLKLALAVEFAT.KDLKIKIN.DTV..DS...PSL--TTDK.VHLFDADAILRYAMD.....QFSG.AfTSESFD-SLSKLEPALYK....EELTTHDKEHAVH-ALKNYL.VSnLKDTDSATKLITFANV-a...................................................................
E7NI85_YEASO/11-132             ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VE.LKEPLTATDLILFANVY....................................................................
G8BNZ1_TETPH/11-80              ................KEHPQELLIANNLKLTIALEFKT.KDLKLSVN.EDL..KT...PSL-SINDQ.FRLFNTDAILRYALN.....DFEG.L.N-----------------....--------------------.--.-----------------vevss...............................................................
C4Y0R7_CLAL4/7-117              .............rgs---TL-LALVNNLKVSIAAAAFA.PEA--QVE.PAD..SG...LLFRDSKSG.FELAEANAIVKYLAK.....DFAP.S.PVFAVE------ENEIYS....-ALKSQSREKAVD-ALSKLS.VP.ESTELSAANIVLYAAAY....................................................................
K0KGG6_WICCF/3-89               sahvaqnvakfsspvy-----------------------.--------.---..--...-----GKDG.FELSEPNAIVKYLAN.....DFTQ.T.SEIDYE------EEILHV....LLNSGKSDESILTKSPATKL.--.--EKLTASSIILFASTF....................................................................
G8YUH6_PICSO/10-122             .............cgt----SLLALSNNLKVAIATKLYK.PDLDFQNK.EDE..SG...LKLRNNADG.FELLEANSIVKYLSN.....DFST.S.EDLEFE------ETVLFSa..lKSGKKDEIEGALK--SRNFS.--.FGKDVSASLIILFASVY....................................................................
A5DIE2_PICGU/10-123             ............rgsd----L-LALASNLKVCIGALVFQ.GGIQVELG.EDE..SH...TGLKDSKTG.FRLLESNAIVKYLAK.....DFKR.T.EAIEFE------ETKLYQa..lKSNQKEQIMALSD-LLPDFA.--.DNQEITAEKVIIFSALY....................................................................
U4L9B9_PYROM/13-139             ...........aekgt------VAFTAALKVCLAAAAFE.VQLQYSTA.PGE..SI...VKLEAPKEH.KSLIEANAIVRYFAS.....----.-.------------------....--------------------.--.-----------------vgskpwgktgeellkdnallefeesilaslvakksdealtiaestiakatlttevpspaeiaffatly
C5MJ30_CANTT/9-120              ...............k-GSSL-LALSNNLKLAIALSSYQ.PKLSLTLN.ETE..SQ...LSLKDKKSG.FELIEPNAIVKYLAN.....DFTN.D.KAIKFE------EQVVYPv..lKSNKSDGILKISD--LPSFE.--.-KAEITPAQIILFSSLY....................................................................
SYMC_YEAST/11-132               ................KKHPAHLQLANNLKIALALEYAS.KNLKPEVD.NDN..AA...MELRNTKEP.FLLFDANAILRYVMD.....DFEG.Q.TSDKYQFALASLQNLLYH....KELPQQHVEVLTNKAIENYL.VE.LKEPLTTTDLILFANVY....................................................................
#=GR SYMC_YEAST/11-132    SS    ................HHHHH--STT--EE-SS--S--E.E-S--S--.-HH..HH...T--TTTTSH.HHHHHHHTTTGGGSS.....HHHH.H.HHHHHT-S---SS--HHH....HHHHXXXXXXXXXXXXXXXX.XX.XXXXXXXXXXXXXXXXX....................................................................
B5RUW5_DEBHA/10-123             ...............k-GSSL-LTLASNLKLSLVSAIYQ.PKLSVSLS.ENE..SS...LSLIDKKSG.FELSEPNAIVKYLAN.....DFNK.D.KLLEFE------ETSLYKa..aKSNKKDAIVQAINESSIKL-.--.EKAETSTSQIILFAAVY....................................................................
G0W8A8_NAUDC/11-129             ................KDHSHAISFANNLKIALAIEYAT.KDLKLTIN.DDS..NI...AQL-VVSDS.YQLFNPNAILRYALN.....DFTD.Q.ESEANQFAVTIVEKALIS....SETSSKE---VVTKTLEQYLpYP.IEEPVSATKLILLAD--il..................................................................
G8JSR6_ERECY/11-132             ...............k-TQLSGLQLATNIKLALALQLGDiSASKIAVN.DEA..VG...PQL-FGPPL.FRLFDSNAILRYVMD.....DFEG.L.DSEEGLFALSSVEAVLHH....KSIQKEHVESIASKSLDSYL.LS.LQEPLSATKLITFANTY....................................................................
J8Q7R6_SACAR/11-132             ................KQHPTHLQLANNLKIALALEFTG.EKLKLEVD.DDS..TT...MELHSAKEP.FTLFDANAILRYVMD.....DFED.Q.SSDKYQFALASLQNLLYH....KELPKQHVEVLTIKAIENYL.TE.LREPLTATDLILFANIY....................................................................
C5DD77_LACTC/11-132             ................KDHSYALQLANNIKLALAQELAG.KEIKISVN.DES..VK...PELTVASTD.FRLFNTNAILRYVLN.....DFEG.L.ESSETHFAVSSLEAMLYH....PSAPQEHVKENVSKALENYL.QE.LREPFCATNLITFANAY....................................................................
J5PNA7_SACK1/11-132             ................KKHPAHLQLANNLKIALALGLAN.KNLKLEVN.DDN..AA...MELCSTKEA.FTLFDANAILRYIMD.....DFED.Q.SSDKYQFALASLQNLLYH....KELPGQHVEVLTNKAFENYL.AE.LKEPLTATDLILFANVY....................................................................
Q6CXB8_KLULA/38-158             ................KGHTSALQLANNIKLAYAL-LSS.GNLKLEEN.KDV..LI...PQLVIDSTG.FRLFDANAILRYVLN.....DFEE.E.ESNEYNFAVSSLEAFASH....KDPIKEHLAEAVQKSLDNYL.TS.VEEPLSATRIVIFANTY....................................................................
C4YRX9_CANAW/9-120              ................KGNTL-LALTNNLKLSIALAAFE.PKVELTLN.EVE..SN...LSLKDKKSG.FELIEPNAIVKYLAK.....DFTT.T.EAIKFE------EQVLYSa..iKSNKKDELAKITD--LPKFA.--.-KEELTPSQIIVFASLY....................................................................
G8B6J5_CANPC/9-122              ................KDKTL-LALVNNLKLSIAAAAYD.PKLVVKLP.EDS..DHqigVLLKDKKTG.FELFEPNAIVKYLAK.....NYTI.D.EHIKIE-EKELHQAVLTN....RKESLEQVQVSTP-------.--.SKVEVNPSQIILFSSLY....................................................................
G3ASH9_SPAPN/10-121             ...............k-GSSL-LTLSTNLKLCIATSAFQ.PKLSVS-N.DTP..SD...ALLKDKKSD.FALHEVNAVVKYLAN.....DFST.N.EAIQFE------ETQLYKa..lKSNKKEKLTSAVSGSIT-FT.--.-KAELTPAQIILFASVY....................................................................
G8C088_TETPH/11-132             ................KHDTNLLKLANNLKLLLGVEYNN.RDFEIEMD.EDC..QI...PRL--MSDT.VCLYEPNAILRYLIN.....DYHG.I.EDEEYERFVKKFDNLCHKefgnKEDMQSELQ--MEVAADKYL.QN.LENNVTANDLILFADVY....................................................................
G8ZYF8_TORDC/11-131             ................KGRQQALSLSNNLKITLALEYAS.KDFKIAVN.EEL..EG...PQL-INGDN.LRLIDTDAILRYILN.....DFEG.Q.RSDEYHYALSSLESLFQK....NDIPEQHVEACVSKSLDNYL.LS.LEEPLSATRLITFANTY....................................................................
G3B4G5_CANTC/10-122             ................KGNST-LSLVNNLKVTVAAKAAD.GNLKVNS-.EDD..SN...LKLLNKATG.FELTEPNAIVKYLIN.....DFDS.A.SILSIE----ETAVYSAH....KSGKKEEVISFIKSESSPFT.--.-KAELTASQIILFSSVY....................................................................
Q6FTV8_CANGA/11-130             ................KGRDAKVVLANNLKIALAIELA-.KGLKLSIN.EDR..SE...PLL--TAGE.LVLRDANAILRYALD.....DFEG.I.HSEQYHYALSSVEAYLYH....QQSSEEHATELVNKMIDNYLkLD.KDSKLDAVTLISFANAY....................................................................
C5DVL1_ZYGRC/11-131             ................KGHAQAVTFANNFKIALGLEYAA.KGTKTTVN.EDN..VG...PAL-IQGES.FRLFDSNAILRYLLN.....DFAP.Q.QVDEYEYALSSLEHLLHQ....KQVPKEHADECVDKALNNYL.TS.LEEPLSATRLISFVNAY....................................................................
#=GC SS_cons                    ................HHHHH--STT--EE-SS--S--E.E-S--S--.-HH..HH...T--TTTTSH.HHHHHHHTTTGGGSS.....HHHH.H.HHHHHT-S---SS--HHH....HHHHXXXXXXXXXXXXXXXX.XX.XXXXXXXXXXXXXXXXX....................................................................
#=GC seq_cons                   .................tps..LsLuNNLKlulAhphhs.tslclpls.--s..st...hpL.sspss.FcLh-sNAIl+Ylhs.....DFps.p.pu.cac......EshLap....cp..pcclpthss.tltpah.....cp.loAoplIlFAssY....................................................................
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