#=GF ID Mrr_cat
#=GF AC PF04471.7
#=GF DE Restriction endonuclease
#=GF AU Waterfield DI, Finn RD
#=GF SE COG1715
#=GF GA 21.00 21.00;
#=GF TC 21.00 21.00;
#=GF NC 20.90 20.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 1650347
#=GF RT Characterization and expression of the Escherichia coli Mrr
#=GF RT restriction system.
#=GF RA Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ,
#=GF RA Benner JS;
#=GF RL J Bacteriol 1991;173:5207-5219.
#=GF RN [2]
#=GF RM 11313145
#=GF RT Identification of a PD-(D/E)XK-like domain with a novel
#=GF RT configuration of the endonuclease active site in the
#=GF RT methyl-directed restriction enzyme Mrr and its homologs.
#=GF RA Bujnicki JM, Rychlewski L;
#=GF RL Gene 2001;267:183-191.
#=GF DR INTERPRO; IPR007560;
#=GF CC Prokaryotic family found in type II restriction enzymes
#=GF CC containing the hallmark (D/E)-(D/E)XK active site. Presence of
#=GF CC catalytic residues implicates this region in the enzymatic
#=GF CC cleavage of DNA [1,2].
#=GF SQ 2560
#=GS B2UHD2_RALPJ/147-260 AC B2UHD2.1
#=GS C4K4I3_HAMD5/192-297 AC C4K4I3.1
#=GS I0M291_SALET/163-281 AC I0M291.1
#=GS D4VKC3_9BACE/1-106 AC D4VKC3.1
#=GS Q1R2F7_ECOUT/163-281 AC Q1R2F7.1
#=GS B6UYU8_KLEPN/64-174 AC B6UYU8.1
#=GS G7BMW8_VIBCL/1009-1128 AC G7BMW8.1
#=GS H3LXS6_KLEOX/197-311 AC H3LXS6.1
#=GS F4QUT3_BREDI/158-274 AC F4QUT3.1
#=GS B0TUB1_SHEHH/27-130 AC B0TUB1.1
#=GS C3BV54_9BACI/34-144 AC C3BV54.1
#=GS D5MIL6_9BACT/161-272 AC D5MIL6.1
#=GS A5KTH0_9BACT/161-273 AC A5KTH0.1
#=GS D9USN3_9ACTO/98-215 AC D9USN3.1
#=GS H2J419_MARPK/374-489 AC H2J419.1
#=GS A1ZMI1_9BACT/31-158 AC A1ZMI1.1
#=GS E3GUT0_HAEI2/198-310 AC E3GUT0.1
#=GS H3K5Q1_9FIRM/202-319 AC H3K5Q1.1
#=GS B2JAG9_NOSP7/150-261 AC B2JAG9.1
#=GS Q8D9X4_VIBVU/126-248 AC Q8D9X4.2
#=GS A4XH73_CALS8/10-127 AC A4XH73.1
#=GS B5SEQ2_RALSL/107-223 AC B5SEQ2.1
#=GS C9LPZ8_9FIRM/128-245 AC C9LPZ8.1
#=GS F9CVR4_9ARCH/63-182 AC F9CVR4.1
#=GS D3HSW0_LEGLN/10-124 AC D3HSW0.1
#=GS F1W140_9BURK/2-114 AC F1W140.1
#=GS D8NDB9_RALSL/106-216 AC D8NDB9.1
#=GS Q6NA85_RHOPA/197-309 AC Q6NA85.1
#=GS D8NK44_RALSL/110-221 AC D8NK44.1
#=GS A3WL27_9GAMM/111-221 AC A3WL27.1
#=GS F4GFN4_ALIDK/15-157 AC F4GFN4.1
#=GS B3W8R7_LACCB/72-182 AC B3W8R7.1
#=GS F3JCW1_PSESX/166-284 AC F3JCW1.1
#=GS D8NSL6_RALSL/107-218 AC D8NSL6.1
#=GS C7QNT2_CYAP0/147-264 AC C7QNT2.1
#=GS F8ZWI2_VIBCL/1009-1128 AC F8ZWI2.1
#=GS E2U1C8_MYCTU/160-280 AC E2U1C8.1
#=GS D2ZP14_METSM/1-113 AC D2ZP14.1
#=GS C4ZT34_ECOBW/163-281 AC C4ZT34.1
#=GS H1DPP7_ECOLX/242-359 AC H1DPP7.1
#=GS C7M3B5_ACIFD/142-258 AC C7M3B5.1
#=GS H9K838_APIME/306-415 AC H9K838.1
#=GS B0R9I9_HALS3/14-126 AC B0R9I9.1
#=GS C6E2C7_GEOSM/1115-1234 AC C6E2C7.1
#=GS E6IGQ3_ENTFL/173-292 AC E6IGQ3.1
#=GS E7MZZ9_9FIRM/1-76 AC E7MZZ9.1
#=GS B1LZ45_METRJ/138-244 AC B1LZ45.1
#=GS B5ER20_ACIF5/157-281 AC B5ER20.1
#=GS B7AP43_9FIRM/39-149 AC B7AP43.1
#=GS G2E9L6_9FLAO/87-205 AC G2E9L6.1
#=GS D9SRD2_CLOC7/64-181 AC D9SRD2.1
#=GS A0LQV2_ACIC1/142-258 AC A0LQV2.1
#=GS F7PI99_9EURY/515-623 AC F7PI99.1
#=GS Q3IUH1_NATPD/5-123 AC Q3IUH1.1
#=GS I1DT66_9GAMM/116-192 AC I1DT66.1
#=GS F9ZQP1_ACICS/73-182 AC F9ZQP1.1
#=GS Q1WSG1_LACS1/647-756 AC Q1WSG1.1
#=GS H4VQ82_ECOLX/163-281 AC H4VQ82.1
#=GS D7EBZ0_METEZ/250-362 AC D7EBZ0.1
#=GS B9M6M4_GEOSF/14-132 AC B9M6M4.1
#=GS D4XDZ1_9BURK/79-186 AC D4XDZ1.1
#=GS Q3HKJ3_RHOS4/149-268 AC Q3HKJ3.1
#=GS Q1BCJ9_MYCSS/78-186 AC Q1BCJ9.1
#=GS E7YQH4_SALMO/1-119 AC E7YQH4.1
#=GS G2B3W1_ECOLX/19-136 AC G2B3W1.1
#=GS H2HGV0_CORDP/164-283 AC H2HGV0.1
#=GS Q0S453_RHOSR/153-269 AC Q0S453.1
#=GS Q1KY44_9RHOO/136-250 AC Q1KY44.1
#=GS F0NZU9_WEEVC/80-202 AC F0NZU9.1
#=GS B1N0D3_LEUCK/189-306 AC B1N0D3.1
#=GS D7VR85_9SPHI/78-201 AC D7VR85.1
#=GS H1WDS6_9CYAN/341-463 AC H1WDS6.1
#=GS A4EPC3_9RHOB/112-212 AC A4EPC3.1
#=GS E1CXP9_VIBPA/99-210 AC E1CXP9.1
#=GS H3QAQ6_BRUAO/36-140 AC H3QAQ6.1
#=GS D3FXT4_BACPE/48-160 AC D3FXT4.1
#=GS Q46FB3_METBF/2-119 AC Q46FB3.1
#=GS Q1D0F6_MYXXD/200-315 AC Q1D0F6.1
#=GS G5ET45_9MICC/238-357 AC G5ET45.1
#=GS B1RPH2_CLOPF/39-130 AC B1RPH2.1
#=GS F8FN77_PAEMK/143-256 AC F8FN77.1
#=GS D8NK50_RALSL/107-217 AC D8NK50.1
#=GS H5WD05_RALSL/24-146 AC H5WD05.1
#=GS B9LVS1_HALLT/4-127 AC B9LVS1.1
#=GS F0QUH3_VULM7/1-112 AC F0QUH3.1
#=GS A5G7I7_GEOUR/145-266 AC A5G7I7.1
#=GS Q18DE5_HALWD/1-109 AC Q18DE5.1
#=GS F7N4T9_ECOLX/193-307 AC F7N4T9.1
#=GS H0NQ36_BACCE/64-173 AC H0NQ36.1
#=GS C2P747_BACCE/37-154 AC C2P747.1
#=GS C7TKD0_LACRL/72-182 AC C7TKD0.1
#=GS F8XW23_9GAMM/62-171 AC F8XW23.1
#=GS F4LMC3_TREBD/385-462 AC F4LMC3.1
#=GS H8EU48_MYCTE/106-226 AC H8EU48.1
#=GS B5VY01_SPIMA/334-451 AC B5VY01.1
#=GS C5SZL6_ACIDE/110-221 AC C5SZL6.1
#=GS F0HFL9_9FIRM/99-208 AC F0HFL9.1
#=GS C8W6A1_DESAS/1-106 AC C8W6A1.1
#=GS E7RUR0_9BURK/168-291 AC E7RUR0.1
#=GS D5RPS9_9PROT/1-56 AC D5RPS9.1
#=GS G0Q552_STRGR/105-222 AC G0Q552.1
#=GS E7FY17_ERYRH/18-126 AC E7FY17.1
#=GS D4PNI7_LISMN/9-112 AC D4PNI7.1
#=GS I0DP35_PROST/19-121 AC I0DP35.1
#=GS I0X7A8_9SPIO/327-448 AC I0X7A8.1
#=GS B5RR81_BORRA/342-458 AC B5RR81.1
#=GS C2NDQ6_BACCE/401-518 AC C2NDQ6.1
#=GS H8IMF2_MYCIA/75-184 AC H8IMF2.1
#=GS H6SF13_MYCTU/160-280 AC H6SF13.1
#=GS D2RPU1_HALTV/4-125 AC D2RPU1.1
#=GS A3RQA9_RALSL/107-223 AC A3RQA9.1
#=GS H1UU06_ACEPA/165-274 AC H1UU06.1
#=GS H8FF66_XANCI/39-150 AC H8FF66.1
#=GS H0PMR2_9SYNC/189-298 AC H0PMR2.1
#=GS D6FYR8_MYCTU/160-280 AC D6FYR8.1
#=GS A5INJ5_THEP1/98-213 AC A5INJ5.1
#=GS B1VPP6_STRGG/83-200 AC B1VPP6.1
#=GS Q1IF77_PSEE4/195-309 AC Q1IF77.1
#=GS E2NNR4_9FIRM/253-377 AC E2NNR4.1
#=GS F6D6X0_METSW/1-113 AC F6D6X0.1
#=GS A5VPR9_BRUO2/36-140 AC A5VPR9.1
#=GS C7P4Z6_HALMD/224-337 AC C7P4Z6.1
#=GS F0M111_VIBFN/5-131 AC F0M111.1
#=GS A5WQD6_MYCTF/160-280 AC A5WQD6.1
#=GS G4IJP9_9EURY/4-127 AC G4IJP9.1
#=GS B3XQB9_LACRE/54-173 AC B3XQB9.1
#=GS P73936_SYNY3/189-298 AC P73936.1
#=GS D0SH61_ACIJO/8-124 AC D0SH61.1
#=GS Q2BBC8_9BACI/17-126 AC Q2BBC8.1
#=GS D9WW35_9ACTO/389-502 AC D9WW35.1
#=GS H6CHP0_9BACL/47-161 AC H6CHP0.1
#=GS A3NFC6_BURP6/208-325 AC A3NFC6.1
#=GS F3JIK6_PSESX/157-277 AC F3JIK6.1
#=GS F0M108_VIBFN/5-130 AC F0M108.1
#=GS G2HUG3_9PROT/12-134 AC G2HUG3.1
#=GS B5HTH6_9ACTO/266-380 AC B5HTH6.1
#=GS F6IHV5_9SPHN/3-123 AC F6IHV5.1
#=GS E3T5I3_9VIRU/85-174 AC E3T5I3.1
#=GS Q5JIG6_PYRKO/8-125 AC Q5JIG6.1
#=GS G1YKM5_ECOLX/213-327 AC G1YKM5.1
#=GS H2J8Q1_9CLOT/194-304 AC H2J8Q1.1
#=GS I0HY18_RUBGE/180-298 AC I0HY18.1
#=GS E9ZLW0_MYCTU/160-280 AC E9ZLW0.1
#=GS E4NHT0_KITSK/442-559 AC E4NHT0.1
#=GS C2VC14_BACCE/59-168 AC C2VC14.1
#=GS C4FIM0_9AQUI/154-274 AC C4FIM0.1
#=GS C2PFI5_BACCE/1-41 AC C2PFI5.1
#=GS D9CH13_ECOLX/71-181 AC D9CH13.1
#=GS Q027W9_SOLUE/11-127 AC Q027W9.1
#=GS A4G161_HERAR/136-248 AC A4G161.1
#=GS F4BZ54_METCG/2-61 AC F4BZ54.1
#=GS F7NSD2_9GAMM/6-130 AC F7NSD2.1
#=GS I0EGT3_HELPX/76-185 AC I0EGT3.1
#=GS A8T0E6_9VIBR/124-246 AC A8T0E6.1
#=GS Q7D429_AGRT5/5-123 AC Q7D429.1
#=GS F8XR71_9GAMM/157-281 AC F8XR71.1
#=GS E9AAK9_SALET/163-281 AC E9AAK9.1
#=GS H1XM93_9XANT/66-181 AC H1XM93.1
#=GS E2EAN2_KLEPN/62-172 AC E2EAN2.1
#=GS D4I712_ERWAE/267-376 AC D4I712.1
#=GS Q3BUZ9_XANC5/41-152 AC Q3BUZ9.1
#=GS D7D8T8_STAHD/71-155 AC D7D8T8.1
#=GS E4U410_SULKY/1-137 AC E4U410.1
#=GS H1MWT2_9PLAN/150-260 AC H1MWT2.1
#=GS C5T069_ACIDE/410-523 AC C5T069.1
#=GS E0NJS0_9FIRM/182-292 AC E0NJS0.1
#=GS F1WL19_MORCA/169-268 AC F1WL19.1
#=GS G2EHX2_CORGT/151-268 AC G2EHX2.1
#=GS B7BEL6_9PORP/157-281 AC B7BEL6.1
#=GS B2A7S5_NATTJ/186-315 AC B2A7S5.1
#=GS Q1CUD8_HELPH/76-185 AC Q1CUD8.1
#=GS A2BRH9_PROMS/177-284 AC A2BRH9.1
#=GS C2JCL6_VIBCL/76-189 AC C2JCL6.1
#=GS A0Y551_9GAMM/162-284 AC A0Y551.1
#=GS F9TST6_9VIBR/180-287 AC F9TST6.1
#=GS E8U2L8_ALIDB/105-216 AC E8U2L8.1
#=GS C6BQN8_RALP1/678-795 AC C6BQN8.1
#=GS E7N368_9FIRM/301-433 AC E7N368.1
#=GS H5WBH6_RALSL/107-219 AC H5WBH6.1
#=GS I0PFH3_MYCAB/81-190 AC I0PFH3.1
#=GS Q82SA1_NITEU/150-274 AC Q82SA1.1
#=GS Q9L161_STRCO/124-238 AC Q9L161.1
#=GS I0GZ28_ACTMI/369-483 AC I0GZ28.1
#=GS E0STB6_IGNAA/10-123 AC E0STB6.1
#=GS F2Q929_SALET/70-180 AC F2Q929.1
#=GS B4W4J0_9CYAN/3-119 AC B4W4J0.1
#=GS G7UVY2_PSEUP/39-152 AC G7UVY2.1
#=GS G7SES9_STRSU/7-122 AC G7SES9.1
#=GS C7VGX8_ENTFL/173-292 AC C7VGX8.1
#=GS D3PWR3_STANL/206-321 AC D3PWR3.1
#=GS G8R234_OWEHD/6-121 AC G8R234.1
#=GS Q2B7W4_9BACI/246-362 AC Q2B7W4.1
#=GS B2VHJ0_ERWT9/191-305 AC B2VHJ0.1
#=GS I0ETL4_9HELI/71-180 AC I0ETL4.1
#=GS A6T2V4_JANMA/60-139 AC A6T2V4.1
#=GS F8ZLJ3_VIBCL/1009-1128 AC F8ZLJ3.1
#=GS F2I9I8_FLUTR/86-206 AC F2I9I8.1
#=GS E1GXY7_9BACT/955-1069 AC E1GXY7.1
#=GS F4T9B2_ECOLX/163-281 AC F4T9B2.1
#=GS B4F0V4_PROMH/661-773 AC B4F0V4.1
#=GS A3VWG4_9RHOB/10-126 AC A3VWG4.1
#=GS I0LQ76_SALET/163-281 AC I0LQ76.1
#=GS H1IYW7_9BACT/96-217 AC H1IYW7.1
#=GS B7J8J6_ACIF2/267-378 AC B7J8J6.1
#=GS B1VV13_STRGG/122-236 AC B1VV13.1
#=GS Q31MJ7_SYNE7/157-277 AC Q31MJ7.1
#=GS F1XG02_MORCA/169-290 AC F1XG02.1
#=GS D9XJL6_9ACTO/258-380 AC D9XJL6.1
#=GS B9LXG3_HALLT/2-59 AC B9LXG3.1
#=GS C6CZ80_PAESJ/65-177 AC C6CZ80.1
#=GS D6A118_9ACTO/162-276 AC D6A118.1
#=GS F8D5N0_HALXS/413-537 AC F8D5N0.1
#=GS C1MEL7_9ENTR/177-291 AC C1MEL7.1
#=GS C5VUE4_9VIRU/60-172 AC C5VUE4.1
#=GS D7DQR7_METV3/10-136 AC D7DQR7.1
#=GS Q1PZU8_9BACT/355-472 AC Q1PZU8.1
#=GS I1DRS6_9PROT/153-271 AC I1DRS6.1
#=GS B0MYF3_9BACT/1-107 AC B0MYF3.1
#=GS I0SEM1_STRCV/56-109 AC I0SEM1.1
#=GS Q8ZK17_SALTY/191-305 AC Q8ZK17.1
#=GS D1AM77_SEBTE/203-320 AC D1AM77.1
#=GS H8MR52_CORCM/4-71 AC H8MR52.1
#=GS E6Q8T1_9ZZZZ/282-390 AC E6Q8T1.1
#=GS F2GTI6_BRUM5/36-140 AC F2GTI6.1
#=GS H3QJ98_BRUAO/36-140 AC H3QJ98.1
#=GS D4S2S7_9FIRM/183-307 AC D4S2S7.1
#=GS C2JS62_ENTFL/4-124 AC C2JS62.1
#=GS Q849K9_STRVN/184-299 AC Q849K9.1
#=GS F5XW90_RAMTT/79-187 AC F5XW90.1
#=GS G0W2C3_PAEPO/113-186 AC G0W2C3.1
#=GS A5UQD9_ROSS1/96-214 AC A5UQD9.1
#=GS F3KUB0_9BURK/75-182 AC F3KUB0.1
#=GS H2H2T6_CORDP/164-283 AC H2H2T6.1
#=GS D6B1V1_9ACTO/222-336 AC D6B1V1.1
#=GS Q2IFN4_ANADE/396-502 AC Q2IFN4.1
#=GS E3YLV1_9LIST/1-61 AC E3YLV1.1
#=GS F3UUG8_STRSA/4-127 AC F3UUG8.1
#=GS A7N3C7_VIBHB/1-75 AC A7N3C7.1
#=GS B3EJU8_CHLPB/34-148 AC B3EJU8.1
#=GS F8KGH7_LACRE/168-287 AC F8KGH7.1
#=GS A7I8Q8_METB6/5-119 AC A7I8Q8.1
#=GS C2HVQ9_VIBCL/125-243 AC C2HVQ9.1
#=GS H0J4P7_9GAMM/159-279 AC H0J4P7.1
#=GS I0HTJ6_RUBGE/107-222 AC I0HTJ6.1
#=GS E8QNN3_HELPR/76-185 AC E8QNN3.1
#=GS G9UUS8_SALMO/197-311 AC G9UUS8.1
#=GS Q5V782_HALMA/4-127 AC Q5V782.1
#=GS G0JSR4_9GAMM/130-241 AC G0JSR4.1
#=GS G0EHC3_PYRF1/255-365 AC G0EHC3.1
#=GS A3PUQ5_MYCSJ/296-418 AC A3PUQ5.1
#=GS D3IMS0_9BACT/5-81 AC D3IMS0.1
#=GS E1IHD0_9CHLR/18-136 AC E1IHD0.1
#=GS Q74A01_GEOSL/2-127 AC Q74A01.1
#=GS D5V0R6_ARCNC/47-149 AC D5V0R6.1
#=GS B4V8R5_9ACTO/270-383 AC B4V8R5.1
#=GS H3P8Y6_BRUAO/36-140 AC H3P8Y6.1
#=GS E0S4Y0_BUTPB/320-430 AC E0S4Y0.1
#=GS G8PX97_PSEFL/151-277 AC G8PX97.1
#=GS F7WVT3_MYCTD/160-280 AC F7WVT3.1
#=GS B7VQD6_VIBSL/55-178 AC B7VQD6.1
#=GS D9XTR0_9ACTO/294-407 AC D9XTR0.1
#=GS B7GIW4_ANOFW/120-233 AC B7GIW4.1
#=GS F7K887_9FIRM/8-123 AC F7K887.1
#=GS D9XLR4_9ACTO/92-209 AC D9XLR4.1
#=GS A5W4N3_PSEP1/1-78 AC A5W4N3.1
#=GS C0R1Z2_BRAHW/431-553 AC C0R1Z2.1
#=GS Q7WGN8_BORBR/79-186 AC Q7WGN8.1
#=GS B0Q3L8_BACAN/42-152 AC B0Q3L8.1
#=GS G7M2D7_9CLOT/16-123 AC G7M2D7.1
#=GS E3HJ45_ACHXA/79-186 AC E3HJ45.1
#=GS D3LBR1_OENOE/161-281 AC D3LBR1.1
#=GS Q73JA3_TREDE/330-442 AC Q73JA3.1
#=GS E7NSV0_TREPH/357-441 AC E7NSV0.1
#=GS H2J089_RAHAC/417-530 AC H2J089.1
#=GS E8AG70_SALMO/1-126 AC E8AG70.1
#=GS I0Q1X3_STROR/7-122 AC I0Q1X3.1
#=GS E4NRD1_HALBP/4-114 AC E4NRD1.1
#=GS E2SIK7_9FIRM/11-134 AC E2SIK7.1
#=GS B9P746_POPTR/94-203 AC B9P746.1
#=GS D5PIQ4_9MYCO/61-170 AC D5PIQ4.1
#=GS G6F4Y3_LACDE/138-257 AC G6F4Y3.1
#=GS D9UD87_9ACTO/112-226 AC D9UD87.1
#=GS E4RYL7_LEAB4/82-202 AC E4RYL7.1
#=GS H1BT49_ECOLX/230-344 AC H1BT49.1
#=GS Q212U1_RHOPB/124-234 AC Q212U1.1
#=GS F8CAN3_MYXFH/166-285 AC F8CAN3.1
#=GS H3PRU9_BRUAO/36-140 AC H3PRU9.1
#=GS G8TXQ0_9FIRM/160-281 AC G8TXQ0.1
#=GS G0HPM9_THES4/11-125 AC G0HPM9.1
#=GS C1ADF7_GEMAT/47-179 AC C1ADF7.1
#=GS Q72Q06_LEPIC/394-510 AC Q72Q06.1
#=GS Q2FPQ8_METHJ/158-278 AC Q2FPQ8.1
#=GS A7I4L6_METB6/94-205 AC A7I4L6.1
#=GS B7R4N9_9EURY/7-124 AC B7R4N9.1
#=GS F3Z7M1_9ACTO/113-226 AC F3Z7M1.1
#=GS D2NP02_ROTMD/258-377 AC D2NP02.1
#=GS B0RKM6_YEREN/62-172 AC B0RKM6.1
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