GenomeNet

Database: Pfam
Entry: NEMO
LinkDB: NEMO
Original site: NEMO 
#=GF ID   NEMO
#=GF AC   PF11577.7
#=GF DE   NF-kappa-B essential modulator NEMO
#=GF AU   Pollington J
#=GF SE   pdb_3brt
#=GF GA   23.20 23.20;
#=GF TC   23.90 23.40;
#=GF NC   23.10 23.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18462684
#=GF RT   Structure of a NEMO/IKK-associating domain reveals architecture
#=GF RT   of the interaction site. 
#=GF RA   Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo
#=GF RA   H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A; 
#=GF RL   Structure. 2008;16:798-808.
#=GF DR   INTERPRO; IPR021063;
#=GF CC   NEMO is a regulatory protein which is part of the IKK complex
#=GF CC   along with the catalytic IKKalpha and beta kinases. The IKK
#=GF CC   complex phosphorylates IkappaB targeting it for degradation
#=GF CC   which results in the release of NF-kappaB which initiates the
#=GF CC   inflammatory response, cell proliferation or cell
#=GF CC   differentiation [1]. NEMO activates the IKK complex's activity
#=GF CC   by associating with the unphosphorylated IKK kinase C
#=GF CC   termini.The core domain of NEMO is a dimer which binds to two
#=GF CC   fragments of IKK [1].
#=GF SQ   207
#=GS K1Q2D0_CRAGI/51-118       AC K1Q2D0.1
#=GS Q3ZC32_BOVIN/37-104       AC Q3ZC32.1
#=GS Q8VC91_MOUSE/44-111       AC Q8VC91.1
#=GS A0A087Y6I8_POEFO/22-89    AC A0A087Y6I8.2
#=GS A0A067R4M7_ZOONE/91-158   AC A0A067R4M7.1
#=GS H2N2R3_ORYLA/37-104       AC H2N2R3.1
#=GS G6D3R2_DANPL/14-81        AC G6D3R2.1
#=GS F1Q438_CANLF/57-124       AC F1Q438.2
#=GS Q7TSS3_MOUSE/62-129       AC Q7TSS3.1
#=GS F6UWD8_HORSE/37-104       AC F6UWD8.1
#=GS H9J3U1_BOMMO/8-75         AC H9J3U1.1
#=GS A0A0M8ZRZ8_9HYME/117-199  AC A0A0M8ZRZ8.1
#=GS G3IBL5_CRIGR/32-99        AC G3IBL5.1
#=GS A3KG41_MOUSE/44-111       AC A3KG41.1
#=GS M7BNP1_CHEMY/66-133       AC M7BNP1.1
#=GS A0A0A0ABW7_CHAVO/10-77    AC A0A0A0ABW7.1
#=GS M3XPH7_MUSPF/37-104       AC M3XPH7.1
#=GS G3RQC2_GORGO/1-49         AC G3RQC2.1
#=GS A0A0L7R7C9_9HYME/255-328  AC A0A0L7R7C9.1
#=GS A3KG37_MOUSE/50-117       AC A3KG37.1
#=GS A0A087WUW6_HUMAN/44-111   AC A0A087WUW6.1
#=GS G1MZZ3_MELGA/37-104       AC G1MZZ3.1
#=GS G1P540_MYOLU/37-104       AC G1P540.1
#=GS G3RVA2_GORGO/112-179      AC G3RVA2.1
#=GS A3KG40_MOUSE/44-111       AC A3KG40.1
#=GS A0A0D9R324_CHLSB/44-111   AC A0A0D9R324.1
#=GS F7GMH9_MACMU/44-111       AC F7GMH9.1
#=GS G3QQD5_GORGO/112-179      AC G3QQD5.1
#=GS G8JLS4_RAT/37-104         AC G8JLS4.1
#=GS D6W9Q5_TRICA/104-171      AC D6W9Q5.1
#=GS B0KWU0_CALJA/44-111       AC B0KWU0.1
#=GS E2RBP8_CANLF/45-112       AC E2RBP8.2
#=GS A0A087VLF1_BALRE/11-78    AC A0A087VLF1.1
#=GS A0A093Q9X9_PHACA/11-78    AC A0A093Q9X9.1
#=GS W5P1P1_SHEEP/38-105       AC W5P1P1.1
#=GS I3MGM9_ICTTR/50-117       AC I3MGM9.1
#=GS H2N9S6_PONAB/37-104       AC H2N9S6.1
#=GS W5LEZ0_ASTMX/43-110       AC W5LEZ0.1
#=GS U3IAG4_ANAPL/37-104       AC U3IAG4.1
#=GS G3Q620_GASAC/36-103       AC G3Q620.1
#=GS G6DE28_DANPL/84-151       AC G6DE28.1
#=GS S9WAZ5_CAMFR/32-99        AC S9WAZ5.1
#=GS F6UWH6_HORSE/37-104       AC F6UWH6.1
#=GS A0A0T6B9C8_9SCAR/152-219  AC A0A0T6B9C8.1
#=GS K7GC11_PELSI/37-96        AC K7GC11.1
#=GS C3YPU4_BRAFL/78-145       AC C3YPU4.1
#=GS W5NAA1_LEPOC/36-103       AC W5NAA1.1
#=GS OPTN_MACMU/37-104         AC Q861Q8.1
#=GS K7FYA9_PELSI/43-110       AC K7FYA9.1
#=GS F7BJ31_CIOIN/30-97        AC F7BJ31.1
#=GS A0A091IVP6_9AVES/4-71     AC A0A091IVP6.1
#=GS H3A533_LATCH/18-85        AC H3A533.1
#=GS A0A0P7XFN4_9TELE/36-98    AC A0A0P7XFN4.1
#=GS A0A0N7ZTH4_9CRUS/23-89    AC A0A0N7ZTH4.1
#=GS H2L9T8_ORYLA/1-49         AC H2L9T8.1
#=GS NEMO_MOUSE/44-111         AC O88522.2
#=GS A0A091D930_FUKDA/7-74     AC A0A091D930.1
#=GS A0A096P3F9_PAPAN/37-104   AC A0A096P3F9.1
#=GS F1QHG7_DANRE/43-110       AC F1QHG7.1
#=GS S7NAS1_MYOBR/37-104       AC S7NAS1.1
#=GS F1M9C4_RAT/37-104         AC F1M9C4.2
#=GS F7GML8_MACMU/44-111       AC F7GML8.1
#=GS OPTN_PONAB/37-104         AC Q5R923.1
#=GS D2I3B5_AILME/48-115       AC D2I3B5.1
#=GS F7GMH3_MACMU/44-111       AC F7GMH3.1
#=GS A0A0D9RL63_CHLSB/37-104   AC A0A0D9RL63.1
#=GS G7PED9_MACFA/37-104       AC G7PED9.1
#=GS H2R099_PANTR/37-104       AC H2R099.1
#=GS A0A091RD94_9GRUI/11-78    AC A0A091RD94.1
#=GS A5WUQ0_DANRE/19-86        AC A5WUQ0.1
#=GS G3PIJ0_GASAC/28-95        AC G3PIJ0.1
#=GS G1RNU9_NOMLE/37-104       AC G1RNU9.1
#=GS C9J2V2_HUMAN/32-99        AC C9J2V2.1
#=GS E2B714_HARSA/95-162       AC E2B714.1
#=GS A0A093Q2G1_9PASS/10-77    AC A0A093Q2G1.1
#=GS K7GRB1_PIG/44-111         AC K7GRB1.1
#=GS W5NAA3_LEPOC/38-105       AC W5NAA3.1
#=GS A0A087UYT3_9ARAC/61-127   AC A0A087UYT3.1
#=GS K7GBZ3_PELSI/37-96        AC K7GBZ3.1
#=GS F6R1Z3_MONDO/97-164       AC F6R1Z3.2
#=GS A0A0J7KNJ7_LASNI/104-171  AC A0A0J7KNJ7.1
#=GS A0A091F0H7_CORBR/1-68     AC A0A091F0H7.1
#=GS H2RI27_PANTR/112-179      AC H2RI27.1
#=GS A0A087X2G2_HUMAN/37-57    AC A0A087X2G2.1
#=GS H3CN64_TETNG/1-67         AC H3CN64.1
#=GS T1JEL1_STRMM/69-136       AC T1JEL1.1
#=GS A0A093ID25_FULGA/11-78    AC A0A093ID25.1
#=GS A0A091GM26_BUCRH/10-77    AC A0A091GM26.1
#=GS M3YEK4_MUSPF/44-111       AC M3YEK4.1
#=GS H2RZL3_TAKRU/15-82        AC H2RZL3.1
#=GS OPTN_DANRE/19-86          AC Q5RI56.2
#=GS A0A091UFN0_PHORB/11-78    AC A0A091UFN0.1
#=GS K7GSV8_PIG/44-111         AC K7GSV8.1
#=GS A0A087X0G7_HUMAN/44-111   AC A0A087X0G7.1
#=GS G5BE21_HETGA/37-104       AC G5BE21.1
#=GS H3A890_LATCH/36-103       AC H3A890.1
#=GS G1RVV7_NOMLE/44-111       AC G1RVV7.1
#=GS A0A0Q3PMM7_AMAAE/37-104   AC A0A0Q3PMM7.1
#=GS S7Q9Q8_MYOBR/32-99        AC S7Q9Q8.1
#=GS W5LAG8_ASTMX/36-103       AC W5LAG8.1
#=GS A0A151MPX7_ALLMI/24-90    AC A0A151MPX7.1
#=GS K7JGS3_NASVI/118-185      AC K7JGS3.1
#=GS OPTN_PIG/37-104           AC Q7YS99.1
#=GS NEMO_HUMAN/44-111         AC Q9Y6K9.2
#=GS NEMO_HUMAN/44-111         DR PDB; 3BRT B; 49-109;
#=GS NEMO_HUMAN/44-111         DR PDB; 3BRV D; 49-110;
#=GS NEMO_HUMAN/44-111         DR PDB; 3BRT D; 49-110;
#=GS NEMO_HUMAN/44-111         DR PDB; 3BRV B; 49-109;
#=GS G1STZ8_RABIT/45-112       AC G1STZ8.1
#=GS G3UCW2_LOXAF/37-104       AC G3UCW2.1
#=GS F7AMM1_CALJA/54-121       AC F7AMM1.1
#=GS A0A091QA59_LEPDC/11-78    AC A0A091QA59.1
#=GS M3X2Y1_FELCA/32-99        AC M3X2Y1.1
#=GS A0A151WU49_9HYME/89-155   AC A0A151WU49.1
#=GS A0A194PMK4_PAPXU/87-162   AC A0A194PMK4.1
#=GS G3TTB2_LOXAF/49-116       AC G3TTB2.1
#=GS NEMO_RAT/44-111           AC Q6TMG5.1
#=GS U3JGS6_FICAL/37-104       AC U3JGS6.1
#=GS L5L0Z9_PTEAL/37-104       AC L5L0Z9.1
#=GS A0A087X1K7_HUMAN/1-55     AC A0A087X1K7.1
#=GS OPTN_HUMAN/37-104         AC Q96CV9.2
#=GS OPTN_HUMAN/37-104         DR PDB; 5EOA B; 37-102;
#=GS OPTN_HUMAN/37-104         DR PDB; 5EOF A; 37-102;
#=GS OPTN_HUMAN/37-104         DR PDB; 5EOA A; 37-101;
#=GS OPTN_HUMAN/37-104         DR PDB; 5EOF B; 37-102;
#=GS A0A194R3L3_PAPMA/87-154   AC A0A194R3L3.1
#=GS A0A0P7UL25_9TELE/35-95    AC A0A0P7UL25.1
#=GS F6WK94_MACMU/37-104       AC F6WK94.1
#=GS A3KG38_MOUSE/56-123       AC A3KG38.1
#=GS H3A892_LATCH/35-102       AC H3A892.1
#=GS OPTN_CHICK/37-104         AC Q90Z16.1
#=GS F6TK31_HORSE/50-117       AC F6TK31.1
#=GS A0A091V7N1_NIPNI/11-78    AC A0A091V7N1.1
#=GS A0A087YE77_POEFO/28-95    AC A0A087YE77.2
#=GS G3TB30_LOXAF/37-104       AC G3TB30.1
#=GS G3RFJ6_GORGO/37-104       AC G3RFJ6.1
#=GS F7DVK0_XENTR/33-100       AC F7DVK0.1
#=GS F6T3V5_CALJA/44-111       AC F6T3V5.1
#=GS E2A3H8_CAMFO/95-162       AC E2A3H8.1
#=GS F6Z6G3_XENTR/31-98        AC F6Z6G3.1
#=GS I3K179_ORENI/15-82        AC I3K179.1
#=GS NEMO_BOVIN/44-111         AC Q95KU9.1
#=GS L5L5S8_PTEAL/19-86        AC L5L5S8.1
#=GS A9QT41_PIG/44-111         AC A9QT41.1
#=GS F7I7M0_CALJA/37-104       AC F7I7M0.1
#=GS F4WV63_ACREC/88-155       AC F4WV63.1
#=GS G3Q622_GASAC/15-82        AC G3Q622.1
#=GS A0A158NUM7_ATTCE/89-155   AC A0A158NUM7.1
#=GS H0WAZ4_CAVPO/45-112       AC H0WAZ4.1
#=GS M3ZQ85_XIPMA/28-95        AC M3ZQ85.1
#=GS W5P590_SHEEP/37-104       AC W5P590.1
#=GS A0A093FHT2_GAVST/11-78    AC A0A093FHT2.1
#=GS H2PXA1_PONAB/112-179      AC H2PXA1.2
#=GS A0A0P7UM68_9TELE/33-100   AC A0A0P7UM68.1
#=GS M7AGA5_CHEMY/1-41         AC M7AGA5.1
#=GS A0A088AEM9_APIME/150-217  AC A0A088AEM9.1
#=GS A0A151NPP5_ALLMI/33-100   AC A0A151NPP5.1
#=GS K7GK94_PIG/44-111         AC K7GK94.1
#=GS F7ADE2_MONDO/44-111       AC F7ADE2.2
#=GS H0XPP3_OTOGA/45-112       AC H0XPP3.1
#=GS H2ZF39_CIOSA/39-85        AC H2ZF39.1
#=GS A0A087RE44_APTFO/11-78    AC A0A087RE44.1
#=GS J9P891_CANLF/44-111       AC J9P891.1
#=GS G1M4E5_AILME/37-104       AC G1M4E5.1
#=GS H0YVJ9_TAEGU/11-78        AC H0YVJ9.1
#=GS A0A087X1B1_HUMAN/44-111   AC A0A087X1B1.1
#=GS H3A891_LATCH/36-103       AC H3A891.1
#=GS G3GVQ4_CRIGR/87-154       AC G3GVQ4.1
#=GS C9JH59_HUMAN/44-111       AC C9JH59.8
#=GS M4A2F1_XIPMA/22-89        AC M4A2F1.1
#=GS H0WGU6_OTOGA/37-104       AC H0WGU6.1
#=GS H2RZL4_TAKRU/28-95        AC H2RZL4.1
#=GS G3VKD7_SARHA/44-111       AC G3VKD7.1
#=GS G1QA20_MYOLU/43-110       AC G1QA20.1
#=GS G1SRQ8_RABIT/1-61         AC G1SRQ8.2
#=GS H2TNH3_TAKRU/32-99        AC H2TNH3.1
#=GS I3IVM4_ORENI/28-95        AC I3IVM4.1
#=GS A0A093GMZ7_TYTAL/11-78    AC A0A093GMZ7.1
#=GS A0A091K0C2_COLST/11-78    AC A0A091K0C2.1
#=GS M3W172_FELCA/37-104       AC M3W172.1
#=GS C9JCG6_HUMAN/44-111       AC C9JCG6.1
#=GS A3KG39_MOUSE/44-111       AC A3KG39.1
#=GS E9Q2Y3_MOUSE/56-123       AC E9Q2Y3.1
#=GS A0A091R889_MERNU/10-77    AC A0A091R889.1
#=GS E9GHY3_DAPPU/22-96        AC E9GHY3.1
#=GS H2RZL1_TAKRU/28-95        AC H2RZL1.1
#=GS W5NFE0_LEPOC/36-103       AC W5NFE0.1
#=GS OPTN_MOUSE/37-104         AC Q8K3K8.1
#=GS A0A091S452_NESNO/11-78    AC A0A091S452.1
#=GS F7GWR3_MACMU/44-111       AC F7GWR3.1
#=GS B0LXP7_PIG/44-111         AC B0LXP7.1
#=GS X6RKL2_HUMAN/37-61        AC X6RKL2.2
#=GS H3A532_LATCH/43-113       AC H3A532.1
#=GS OPTN_RAT/37-104           AC Q8R5M4.3
#=GS L8YA06_TUPCH/44-111       AC L8YA06.1
#=GS G1KMI1_ANOCA/19-86        AC G1KMI1.1
#=GS L9KQB2_TUPCH/37-104       AC L9KQB2.1
#=GS A0A091HVK6_CALAN/11-78    AC A0A091HVK6.1
#=GS G5BFL6_HETGA/1-51         AC G5BFL6.1
#=GS F7DZC7_ORNAN/44-111       AC F7DZC7.1
#=GS E0VHH6_PEDHC/70-137       AC E0VHH6.1
#=GS H2RZL2_TAKRU/28-95        AC H2RZL2.1
#=GS H0VAE0_CAVPO/37-104       AC H0VAE0.1
#=GS A0A154PLS4_9HYME/111-178  AC A0A154PLS4.1
#=GS G1K9C2_ANOCA/37-104       AC G1K9C2.2
#=GS A0A091DTV9_FUKDA/94-161   AC A0A091DTV9.1
#=GS F6UET8_ORNAN/37-104       AC F6UET8.2
#=GS K7GQV6_PIG/44-111         AC K7GQV6.1
#=GS F7GMH1_MACMU/112-179      AC F7GMH1.1
#=GS V8NHC0_OPHHA/37-104       AC V8NHC0.1
#=GS A0A0G2JUB3_RAT/37-104     AC A0A0G2JUB3.1
#=GS C9JN51_HUMAN/44-111       AC C9JN51.8
#=GS F7ASB3_CALJA/49-116       AC F7ASB3.1
#=GS H2TNH4_TAKRU/1-66         AC H2TNH4.1
#=GS F1QHM5_DANRE/43-110       AC F1QHM5.1
K1Q2D0_CRAGI/51-118                  ...le--QALDRIQELHRENNELR...DYLKDNNEKMKLQYQNLSEWKEKIRV.NNARNKEKFDQTKEVVQTMTREN...............
Q3ZC32_BOVIN/37-104                  .....PHELLQQMRELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLYFETQSKEAKERLTALSLEN...............
Q8VC91_MOUSE/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A087Y6I8_POEFO/22-89               ....l-EETVQQMNILIQENRDLK...EALRQTNLTMKERFEGLTVWKEKQRQ.EKDFLEKRLEEARRCIETLTVQN...............
A0A067R4M7_ZOONE/91-158              ....p-EEIQRKLHELLQENLKLK...DTLCQNNLAMKQQFNTLVMWQNELLR.VHKNHKEKFTETKELVLKLRAEN...............
H2N2R3_ORYLA/37-104                  ....l-EETLQQMNILIQENRDLK...EALRQTNLTMKERFEGLSAWREKQKQ.ERDFLENQLKEAQRNMES-----vvgqn..........
G6D3R2_DANPL/14-81                   ...te--ELQKRFGDLLDENFVLK...ETLKQNNDSMKEQFILIASCQEDMLK.THRLHKEKFDETRELVERLRQEN...............
F1Q438_CANLF/57-124                  .....EQGTPETYQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRK.EKEFLMQKFQEARKLVERLSLEK...............
Q7TSS3_MOUSE/62-129                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
F6UWD8_HORSE/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFEIQSKEAKERLMALSHEN...............
H9J3U1_BOMMO/8-75                    ....t-EELQKRFGELLDENLILK...ETLKQNNDSMKEQFLLIASCQEDMMK.THMLHKEKFEETKELVERLRQEN...............
A0A0M8ZRZ8_9HYME/117-199             ....s-AEVHRKLNELLQENTKLK...ETLKQNNIAMKQQFNSLATWHEEIMR.VHQDHKKKFAETRELINYLKKENadlkmrlsteltsht
G3IBL5_CRIGR/32-99                   .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A3KG41_MOUSE/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
M7BNP1_CHEMY/66-133                  .....PEEMVQQMKELITENNELK...EAMKIHNQAMKDRYEELSVWREKQKE.EREFYESKFKEAKHYLQVKCLEN...............
A0A0A0ABW7_CHAVO/10-77               .....PEEMVQQMKELITENNELK...EAMKVHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCVEN...............
M3XPH7_MUSPF/37-104                  .....PEELLRQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFEIQSKEAKERLMALSHEN...............
G3RQC2_GORGO/1-49                    .....-------------------...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCRFQEARKLVERLSLEK...............
A0A0L7R7C9_9HYME/255-328             ...st--EVHHKLNELLQENTKLK...ETLKQNNTAMKHQFNTLATWQEEIMK.VHQNHKKKFAETRELINYLKKENtelkvr.........
A3KG37_MOUSE/50-117                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A087WUW6_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
G1MZZ3_MELGA/37-104                  .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYEAKFKEAKQCLLAKCIEN...............
G1P540_MYOLU/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFQELSAWTEKQKE.ERHFFEIQSKEAKERLMAVSHEN...............
G3RVA2_GORGO/112-179                 ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCRFQEARKLVERLSLEK...............
A3KG40_MOUSE/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A0D9R324_CHLSB/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
F7GMH9_MACMU/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
G3QQD5_GORGO/112-179                 ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCRFQEARKLVERLSLEK...............
G8JLS4_RAT/37-104                    .....PEELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQLFEIQSKEAKERLKALSHEN...............
D6W9Q5_TRICA/104-171                 ....y-EEIQKQVEELIKENEKLK...NIIAQNNMSMKAQYTRFLAYRDEVTN.VMKSYKDKFNDAKMCIDKYKEEN...............
B0KWU0_CALJA/44-111                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
E2RBP8_CANLF/45-112                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLYFEVQSKEAKERLMALSHEN...............
A0A087VLF1_BALRE/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLQAKCIEN...............
A0A093Q9X9_PHACA/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLDKCIEN...............
W5P1P1_SHEEP/38-105                  .....EQGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGNQRE.EKAFLMQKFQEARDLVARLSLEK...............
I3MGM9_ICTTR/50-117                  ....e-QGIPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMHKFQEARKLVERLSLEK...............
H2N9S6_PONAB/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
W5LEZ0_ASTMX/43-110                  ...el--AGNEVVHRLLADNHQLR...EALKRSNDALKDRCEEMEGWQRRSRE.EREFLSCKFREARALVERLAQEN...............
U3IAG4_ANAPL/37-104                  .....PEEMVQQMKELITENNELK...EAMKLHNQAMKERYEELSIWREKQKE.EREFYETKFKEAKQCLLAKCVEN...............
G3Q620_GASAC/36-103                  ....l-EETLQQMNILIQENRDLK...EALRQTNLMMKDRFEGLSAWREKQRE.ERDFLENKLEDARGRMEALTLQN...............
G6DE28_DANPL/84-151                  ...te--ELQKRFGDLLDENFVLK...ETLKQNNDSMKEQFILIASCQEDMLK.THRLHKEKFDETRELVERLRQEN...............
S9WAZ5_CAMFR/32-99                   .....EQGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRLQGSQRE.EKEFLMQKFQEARKLVERLSLEK...............
F6UWH6_HORSE/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFEIQSKEAKERLMALSHEN...............
A0A0T6B9C8_9SCAR/152-219             ...pd--EIQRKVDNLITENSDLK...ETLAQNNMTMKKQVETMIQWQTEVQR.VHEAHKEKFNEMKKYITILTTEN...............
K7GC11_PELSI/37-96                   .....PEEMVQQMKELITENNELK...EAMKIHNQAMKGRYEELSVWREKQ--.------TKFKEAKHCLQAKCLEN...............
C3YPU4_BRAFL/78-145                  ...ag--EMQSYMTELLKDNNSLR...DTIRQNNEDMRQKIKDLEVWKEKQKQ.NQALIVGKFTEAREKVLSLRKEN...............
W5NAA1_LEPOC/36-103                  ...el--AGNEIVQRLLAENQDLR...DAIRQSNQALRDRYEEMLSFRLKNRQ.ERQFLMEKFREARELVERLSREN...............
OPTN_MACMU/37-104                    .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSHEN...............
K7FYA9_PELSI/43-110                  ...el--AGHEALQRFLLENQDLK...EAIRQSNQMLRQRYQEFVGFQAVQRE.EKDFLLLRFREARDVVQKLNAE-r..............
F7BJ31_CIOIN/30-97                   .nsml----SQLLDNLITGNQDLK...QTIKVNNEELYSKCESLLKWKKDVDD.KVKKLFDTCDRARVKVQS-----mkeqn..........
A0A091IVP6_9AVES/4-71                .....PEEMVRQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
H3A533_LATCH/18-85                   ..eln---SQEALQRLQAENYDLR...EAMRQSNLALRERYDELLAFRARNKE.EKDFMLERFKEARCLVEKLSQEK...............
A0A0P7XFN4_9TELE/36-98               ..ela---DNEVIQRLLGDNNQLR...AALKQSNAALRSRCEEVQGWHQKLRE.EREFLGKRFQEARDL--------pme............
A0A0N7ZTH4_9CRUS/23-89               ....v--EVEEKIQQLITENTDLR...NTLQQNNTYMKQLSSTLVEWQDEVVR.VQNVYHSKVEKAKEVIIKLKEEN...............
H2L9T8_ORYLA/1-49                    .....-------------------...EALRRSNQALRLRCEEMEGWQQRTRD.EREFLSCRFQEARALVERLAQEN...............
NEMO_MOUSE/44-111                    .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A091D930_FUKDA/7-74                ....e-QGSPEALQRCLEENHELR...DAIQQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A096P3F9_PAPAN/37-104              .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSHEN...............
F1QHG7_DANRE/43-110                  ...dl--AGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSRE.EREFLSCRFREARELVQRLAQEN...............
S7NAS1_MYOBR/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFQELSAWTEKQKE.ERHFFEIQSKEAKERLMAVSHEN...............
F1M9C4_RAT/37-104                    .....PEELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQLFEIQSKEAKERLKALSHEN...............
F7GML8_MACMU/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
OPTN_PONAB/37-104                    .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
D2I3B5_AILME/48-115                  .....EQGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRK.EKEFLMQKFQEARKLVERLSLEK...............
F7GMH3_MACMU/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A0D9RL63_CHLSB/37-104              .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSHEN...............
G7PED9_MACFA/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSHEN...............
H2R099_PANTR/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
A0A091RD94_9GRUI/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYEIKFKEAKQCLLAKCIEN...............
A5WUQ0_DANRE/19-86                   ....l-EETLQQMNTLIKENRDLK...EALKQTNLSMKERFEGLSAWKEKQKE.ERDFLEQRLEEARTRLNTMDVEN...............
G3PIJ0_GASAC/28-95                   ...el--ASNEVVTRLLGDNQQLR...EALRRSNVALRQRCEEMEGWQQRTRD.EREFLSCRFQEARALVERLAQEN...............
G1RNU9_NOMLE/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
C9J2V2_HUMAN/32-99                   ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
E2B714_HARSA/95-162                  ...in--ETHKKLTELLQENTKLK...ETLKQNSLAMKKQLSTMASWQGIVMK.LHENHKKKFKETTDLINNLKREN...............
A0A093Q2G1_9PASS/10-77               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYESKFKEAKQCLQAKCIEN...............
K7GRB1_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
W5NAA3_LEPOC/38-105                  ...el--AGNEIVQRLLAENQDLR...DAIRQSNQALRDRYEEMLSFRLKNRQ.ERQFLMEKFREARELVERLSREN...............
A0A087UYT3_9ARAC/61-127              veiqa------RLVELLEENAALK...EALKKNNIIMQEQMSTVTAWHSQVTA.SMSLHQSSLHESRKRIQQLEKEN...............
K7GBZ3_PELSI/37-96                   .....PEEMVQQMKELITENNELK...EAMKIHNQAMKGRYEELSVWREKQ--.------TKFKEAKHCLQAKCLEN...............
F6R1Z3_MONDO/97-164                  .....PEEMLKQMKELLIENHQLK...EAMKLNNQTMKGRFEELSAWTEKQKE.ERQCFELKFKEVKENLLSLSNEN...............
A0A0J7KNJ7_LASNI/104-171             ....a-DEMQKKLSDMLQENVKLK...ETLRLNTLSMKEQFNTLAMWQEKVMK.VHETHKKKFAETRELVNHLKKEN...............
A0A091F0H7_CORBR/1-68                .....PEEMLQQMKELITENNELK...EAMKLHNQAMKDRYEELSTWREKQKE.EREFYELKFKEAKQCLQAKCIEN...............
H2RI27_PANTR/112-179                 ....e-QGAPETLQRCLEENQELR...DAIRQSNQCCGKRCEEVLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A087X2G2_HUMAN/37-57               .....PEELLQQMKELLTENHQLK...--------------------------.-----------------------gp.............
H3CN64_TETNG/1-67                    .....-EETLHQMNILIQENRDLK...ESLRQTNLMMKDRFEDLAVWREKQRG.ERDILERQLEEARVHMEALTHQ-n..............
T1JEL1_STRMM/69-136                  ...pd--EIQTRLRDLLNENLELK...ETLHENNAAMSEQFGRLSQWQKEVEF.AQSQNKVKFEESRDLIGKLREEN...............
A0A093ID25_FULGA/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
A0A091GM26_BUCRH/10-77               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSVWREKQKE.EREFYELKFKEAKQCLLAKCVEN...............
M3YEK4_MUSPF/44-111                  .....EQGTPETFQRCLEENQELR...DAIRQSNQVLRERCEELQRFQGSQRK.EKEFLVQKFQEARKLVERLSLEK...............
H2RZL3_TAKRU/15-82                   ...el--AANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSRE.DREFLSCRFQEARALVERLAEK-n..............
OPTN_DANRE/19-86                     ....l-EETLQQMNTLIKENRDLK...EALKQTNLSMKERFEGLSAWKEKQKE.ERDFLEQRLEEARTRLNTMDVEN...............
A0A091UFN0_PHORB/11-78               .....PEEMVQQMKELITENNELK...EAMKVHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
K7GSV8_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
A0A087X0G7_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
G5BE21_HETGA/37-104                  .....PEELLQQMKELLAENHQLK...EAMKLNNQAMKGRFEELSAWTERQKE.ERQFFEMQSKEAKERLMALSHEN...............
H3A890_LATCH/36-103                  .....PEETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRGRQKE.EREFLERKFQEAKEKLLALTKEN...............
G1RVV7_NOMLE/44-111                  ....e-HGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
A0A0Q3PMM7_AMAAE/37-104              .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFFESKFKEAKQCLLAKCTEN...............
S7Q9Q8_MYOBR/32-99                   ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRECCEELQRFQGSQRE.EKEFLMQKFQEARKLVERLNLEK...............
W5LAG8_ASTMX/36-103                  ....v-EETLQQMNILIKENRELK...EALKQTNLSMKERFEGLTVWKEKQKE.ERSFLESRLEEARQRVHALDSEN...............
A0A151MPX7_ALLMI/24-90               .apdp-----EAWQRLAAENQDLK...EALRQGNQALRLRCQEFQQVQAMRRE.ERDFLLLRFHEARTLVQQLQNE-q..............
K7JGS3_NASVI/118-185                 ....p-SEIEEKLKNVLEENIKLK...ETLKQNNSATKQQFNTITMWQKDVMT.VCDNHKQKFMETKQLMSRLKKEN...............
OPTN_PIG/37-104                      .....PHELLQQMRELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFETQSKEAKERLTALSLEN...............
NEMO_HUMAN/44-111                    ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
#=GR NEMO_HUMAN/44-111         SS    ....X-XXXX-HHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHHHHCXX...............
G1STZ8_RABIT/45-112                  ....e-QGAPDALQRCLEENQELR...DAIRQSNQMLRERCEELLRFQVSQRE.EKEFLLCKFQEARKLVERLNLEK...............
G3UCW2_LOXAF/37-104                  .....PEELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLIALSHEN...............
F7AMM1_CALJA/54-121                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A091QA59_LEPDC/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSVWREKQKE.EREFYELKFKEAKECLLAKCIEN...............
M3X2Y1_FELCA/32-99                   .....EQGTPETFQRCVEENQELR...DAIRQSNQMLRERCEELQRFQGSQRK.EKEFLMQKFQEARKLVERLSLEK...............
A0A151WU49_9HYME/89-155              ....t--AMQHRLAEVLQENVKLK...ETLRQNNESMKQQFNTLAMWQEEVTE.VHLSHKQKFAETKELINHLKKEN...............
A0A194PMK4_PAPXU/87-162              ....t-EELQKRFGELLDENLVLK...ETLKQNNESLKEQLDLISSCQDDMLN.THKIHREKFDETKNLVKKLREENkmlkadam.......
G3TTB2_LOXAF/49-116                  ....e-QGASEPLQRCLEENQELR...DAFRESNQMLRERCEELLHFQVSQRE.EKEFLMQKFQEARKLVEKLSLEK...............
NEMO_RAT/44-111                      .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
U3JGS6_FICAL/37-104                  .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSTWREKQKE.EREFYELKFKEAKQCLQAKCIEN...............
L5L0Z9_PTEAL/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFEIQSKEAKERLMALSHEN...............
A0A087X1K7_HUMAN/1-55                .....-------------ENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
OPTN_HUMAN/37-104                    .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
#=GR OPTN_HUMAN/37-104         SS    .....HHHHHHHHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHCHH-XX...............
A0A194R3L3_PAPMA/87-154              ....t-EELQKRFGELLDENLVLK...ETLKQNNESLKEQLDLISSCQDDMLN.THKIHKEKFDETKNLVIKLREEN...............
A0A0P7UL25_9TELE/35-95               .dlad----SEAVNRLLGDNHQLR...EALRRSNVALKERCEEMEEWQQRSRK.EREFLSCRFQEARA---------lp.............
F6WK94_MACMU/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSHEN...............
A3KG38_MOUSE/56-123                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
H3A892_LATCH/35-102                  .....PEETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRAKEKLlALTKENEELKK------------tvqiqeekhqk....
OPTN_CHICK/37-104                    .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYETKFKEAKQCLLAKCVEN...............
F6TK31_HORSE/50-117                  .....EQGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQHFQSSQRE.EKEFLMQKFQEARKLVERLSLEK...............
A0A091V7N1_NIPNI/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSVWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
A0A087YE77_POEFO/28-95               ...el--AGNEVVTRLLGDNQQLR...EALRRSNQALRQRCEEMEGWQRRTRE.EREFLSCRFQEARALVERLAQEN...............
G3TB30_LOXAF/37-104                  .....PEELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLIALSHEN...............
G3RFJ6_GORGO/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
F7DVK0_XENTR/33-100                  ..elt---SNEAFQRIWAENHDLR...AALEQSNMMLRKGHGDMLEFQDSQRK.EREFITYKFGEARDLVLRLTNE-r..............
F6T3V5_CALJA/44-111                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
E2A3H8_CAMFO/95-162                  ....t-DEMQKKLSDMLQENVKLK...ETLKQNTLSMKEQFSTLAMWQEEVMK.VHENHKKKFAETRELINHLKKEN...............
F6Z6G3_XENTR/31-98                   .....DAEMLEQIKQLLMENNNLK...ETMKQMNQEMKERLEELLKRHNQHLL.DLNSENELLRKELNSLREKNAT-s..............
I3K179_ORENI/15-82                   ....l-EETLQQMNILIQENRDLK...EALRQTNLTMKERFEGLSAWREKQKE.ERDFLESRLEEARGRMEALTLQN...............
NEMO_BOVIN/44-111                    .....EQGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQHFQGNQRE.EKAFLMQKFQEARDLVVRLSLEK...............
L5L5S8_PTEAL/19-86                   ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRECCEELQRFQGNQRE.EKQFLMQKFQEARKLVERLSVEK...............
A9QT41_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
F7I7M0_CALJA/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSKEAKERLMALSQEN...............
F4WV63_ACREC/88-155                  ...vt--AMQDRLVEVLQENVKLK...ETLRQTNVSMKQHFNTLTMWQEEVTK.VHLSHKQQFAETKELINHLKKEN...............
G3Q622_GASAC/15-82                   ....l-EETLQQMNILIQENRDLK...EALRQTNLMMKDRFEGLSAWREKQRE.ERDFLENKLEDARGRMEALTLQN...............
A0A158NUM7_ATTCE/89-155              ...ta---MQHRLVEVLQENVKLK...ETLRQNNVSMKQQFNTLAMWQEEVTK.VHLSHKQQFAETKELINHLKKEN...............
H0WAZ4_CAVPO/45-112                  ....e-QGSPEALQHCLEENHELR...DAIRQNNQMLRERCEELLHFQASQKE.EREFLMCKFQEARKLVERLSLEK...............
M3ZQ85_XIPMA/28-95                   ...el--AGNEVVTRLLGDNQQLR...EALRRSNQALRQRCEEMEGWQRRTRE.EREFLSCRFQEARALVERLAQEN...............
W5P590_SHEEP/37-104                  .....PHELLQQMRELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLYFETQSKEAKERLTALSLEN...............
A0A093FHT2_GAVST/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
H2PXA1_PONAB/112-179                 ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A0P7UM68_9TELE/33-100              ....l-EETLHQMNILIKENRDLK...EALKHTNFAMKERFEGLSAWKEKQKE.ERDFLEGKLEEAKKHVTVLNKQN...............
M7AGA5_CHEMY/1-41                    .....-------------------...--------MLRQRYQEFLRFQATQRE.EKEFLMLRFREARDVVEKLNTE-r..............
A0A088AEM9_APIME/150-217             ....t-AEVHQKLNELLQENTKLK...ETLKQNNIAMKQQFNVLATWQEEIMR.VHQNHKKKFAETRELINYLKKEN...............
A0A151NPP5_ALLMI/33-100              .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSVWREKQKE.EREFFESKFKEAKNCLQAKCVEN...............
K7GK94_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
F7ADE2_MONDO/44-111                  .sqvs----PEALQRFLEENQELR...DALRQSNQMLRERYQEFVNFQANQKE.EKEFLMRKFQEARTLVEKLKTEK...............
H0XPP3_OTOGA/45-112                  .....EQGTPETLQRCVEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKAFLTHKFQEARKLVERLSLEK...............
H2ZF39_CIOSA/39-85                   ..htm---LNQLLSKLITGNNDLK...QTIRVNNQQLHDKCNALVQWKA----.-----------------------nvdrsv.........
A0A087RE44_APTFO/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
J9P891_CANLF/44-111                  .....EQGTPETYQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRK.EKEFLMQKFQEARKLVERLSLEK...............
G1M4E5_AILME/37-104                  .....PEELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTERQKE.ERLFFETQSKEAKERLMALSHEN...............
H0YVJ9_TAEGU/11-78                   .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSTWREKQKE.EREFYELKFKEAKQCLQAKCIEN...............
A0A087X1B1_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
H3A891_LATCH/36-103                  .....PEETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRGRQKE.EREFLERKFQEAKEKLLALTKEN...............
G3GVQ4_CRIGR/87-154                  .....PEEMLQQMKELLVENHQLK...EAMKLNNQAMKGRYEELSAWAEKQKE.ERQLFDTQNKEAKKLLMTLSYEN...............
C9JH59_HUMAN/44-111                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
M4A2F1_XIPMA/22-89                   ....l-EETVQQMNMLIQENRDLK...EALRQTNLTMKERFEGLTAWKEKQRQ.EKDFLEKRLEEARRCIETLTVQN...............
H0WGU6_OTOGA/37-104                  .....PEELLRQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFETQSREAKQRLMALSHEN...............
H2RZL4_TAKRU/28-95                   ...el--AANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSRE.DREFLSCRFQEARALVERLA---eks............
G3VKD7_SARHA/44-111                  ..nqv---SPEALQRCLEENQELR...DALRQSNHMLRQRYQEFLNFQANQKE.EKEFLMQKFQEARKLVEKLNMEK...............
G1QA20_MYOLU/43-110                  ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRECCEELQRFQGSQRE.EKEFLMQKFQEARKLVERLNLEK...............
G1SRQ8_RABIT/1-61                    .....-------MKELLTENHQLK...EAMKLNNQAMKGRFEELSAWSEKQKE.ERQFFELQSKESKERIMALSHEN...............
H2TNH3_TAKRU/32-99                   ....l-EETLHQMNILIQENRDLK...ESLRQTNLAMKERFEGLAAWREKQRE.ERDFLESRLKEARDRMEALTCQN...............
I3IVM4_ORENI/28-95                   ...el--AANEVVTRLLSDNQQLR...EALRRSNLALRQRCEEMEGWQRRTKE.EREFLSCRFQEARSLVERLAQEN...............
A0A093GMZ7_TYTAL/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKE.EREFYELKFKEAKQCLLAKCIEN...............
A0A091K0C2_COLST/11-78               ....a-EEVVQQMKELIAENNELK...EAMRLHNQAMKDRYEELYLWREKQKE.GREFYEVKFKEAKECLLAKCLEN...............
M3W172_FELCA/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLFFEIQSKEAKERLVALSHEN...............
C9JCG6_HUMAN/44-111                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
A3KG39_MOUSE/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
E9Q2Y3_MOUSE/56-123                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQRE.EKEFLMCKFQEARKLVERLSLEK...............
A0A091R889_MERNU/10-77               .....PEEMVQQMKELITENNELK...EAMKLHNQTMKDRYEELSIWREKQKE.EREFYESKFKEAKQCLLAKCMEN...............
E9GHY3_DAPPU/22-96                   ....v-EEIEEKIQTLITENTGLR...NTLQQNNTYMRQLSSTLVEWQEEVIR.VQSVYQNKVERAKEVITKLKEENaalkeki........
H2RZL1_TAKRU/28-95                   ...el--AANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSRE.DREFLSCRFQEARALVERLAEEN...............
W5NFE0_LEPOC/36-103                  .....PEETLQQMNILIKENSELK...EALKQTNTSMKERFEGLAAWKEKQKE.EREFLENKFLEAKNRVTALTK--rn.............
OPTN_MOUSE/37-104                    .....PEELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERLLFEMQSKEVKERLKALTHEN...............
A0A091S452_NESNO/11-78               .....PEEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSVWREKQKE.EREFFELKFKEAKQCLLAKCIEN...............
F7GWR3_MACMU/44-111                  .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
B0LXP7_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
X6RKL2_HUMAN/37-61                   .....PEELLQQMKELLTENHQLK...E-------------------------.-----------------------pcgqv..........
H3A532_LATCH/43-113                  ..eln---SQEALQRLQAENYDLRvipEAMRQSNLALRERYDELLAFRARNKE.EKDFMLERFKEARCLVEKLSQEK...............
OPTN_RAT/37-104                      .....PEELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQLFEIQSKEAKERLKALSHEN...............
L8YA06_TUPCH/44-111                  ....e-QGIPETLQRCLEENQELR...DAIRQSNQMLRERCEELLRFQVIQRE.EKEFLMQKFQEARRLVERLSLEK...............
G1KMI1_ANOCA/19-86                   ...el--AGHEAVQHVLAENRDLK...EAIQRSNHMLRERYREFLQFQASHKQ.EKEFLFCKFQEARLLVENLQLE-r..............
L9KQB2_TUPCH/37-104                  .....PEELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFELQSKEAKERLIALSHEN...............
A0A091HVK6_CALAN/11-78               .....PEEMVQQMKELITENNELK...EAMKVHNQAMKDRYEELSAWREKQKE.EREFYELKFKEAKQCLEAKCIEN...............
G5BFL6_HETGA/1-51                    ...ml-------------------...DAIRQSNQMLRERCEELLHFQASQRE.EKEFIMCKFQEARKLVERLSLEK...............
F7DZC7_ORNAN/44-111                  ...dq--DPQEALQRFLVENQELR...EAIRQSNQMLREWYKEFLNFQANHKE.EKEFLRRKFQGARNLVERLNLEK...............
E0VHH6_PEDHC/70-137                  .egda----QDKLNHLLQENQKLK...ETLNQNNLAIKSQLNTFFMWQQEVLK.THETHKQKFLETKDLILKLRLEN...............
H2RZL2_TAKRU/28-95                   ...el--AANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSRE.DREFLSCRFQEARALVERLAEEN...............
H0VAE0_CAVPO/37-104                  .....PEELLQQMKELLAENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQFFEIQSKEAKERLMALSHEN...............
A0A154PLS4_9HYME/111-178             ....s-NEVHQKLNELLQENGKLK...ETLKQNNVAMRQQFNTLASWQEEMMK.VHHNHKKKFTETRELMNYLKKEN...............
G1K9C2_ANOCA/37-104                  ....v-EEMVQQMKELITENNELK...EAVRQHNQAMKDRFENLSEWSEKLKE.EREFYEIKFKEARQCLASKCVEN...............
A0A091DTV9_FUKDA/94-161              .....PEELLQQMKELLAENHQLK...EAMRLNNQAMKGRFEELSAWTEKQKE.ERQLFEMQSREAKERLMALSHEN...............
F6UET8_ORNAN/37-104                  .....PEEMLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWREKQKE.ERQFFESKFKEAKERLLALSNEK...............
K7GQV6_PIG/44-111                    ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRE.EKEFLMQKFCEARRLVERLSLEK...............
F7GMH1_MACMU/112-179                 .....EQGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
V8NHC0_OPHHA/37-104                  ....v-EEMVQQMKELITENNELK...EAMRQRNQAMKERFEELSAWKEKLKD.EREFYESKFKEARQCLATKCLEN...............
A0A0G2JUB3_RAT/37-104                .....PEELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKE.ERQLFEIQSKEAKERLKALSHEN...............
C9JN51_HUMAN/44-111                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLGLEK...............
F7ASB3_CALJA/49-116                  ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQRE.EKEFLMCKFQEARKLVERLSLEK...............
H2TNH4_TAKRU/1-66                    .....--ETLHQMNILIQENRDLK...ESLRQTNLAMKERFEGLAAWREKQRE.ERDFLESRLKEARDRMEALTCQN...............
F1QHM5_DANRE/43-110                  ...dl--AGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSRE.EREFLSCRFREARELVQRLAQEN...............
#=GC SS_cons                         .....HHHHHHHHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHCHHCXX...............
#=GC seq_cons                        ......pth.pphpcLLpENp-L+...EAl+psNQsh+-RhEELttappcQ+E.E+-FhppKFpEA+chlptLshEp...............
//
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