GenomeNet

Database: Pfam
Entry: NEMO
LinkDB: NEMO
Original site: NEMO 
#=GF ID   NEMO
#=GF AC   PF11577.4
#=GF DE   NF-kappa-B essential modulator NEMO
#=GF AU   Pollington J
#=GF SE   pdb_3brt
#=GF GA   23.10 23.10;
#=GF TC   23.20 23.40;
#=GF NC   22.90 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18462684
#=GF RT   Structure of a NEMO/IKK-associating domain reveals architecture
#=GF RT   of the interaction site. 
#=GF RA   Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo
#=GF RA   H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A; 
#=GF RL   Structure. 2008;16:798-808.
#=GF DR   INTERPRO; IPR021063;
#=GF CC   NEMO is a regulatory protein which is part of the IKK complex
#=GF CC   along with the catalytic IKKalpha and beta kinases. The IKK
#=GF CC   complex phosphorylates IkappaB targeting it for degradation
#=GF CC   which results in the release of NF-kappaB which initiates the
#=GF CC   inflammatory response, cell proliferation or cell
#=GF CC   differentiation [1]. NEMO activates the IKK complex's activity
#=GF CC   by associating with the unphosphorylated IKK kinase C
#=GF CC   termini.The core domain of NEMO is a dimer which binds to two
#=GF CC   fragments of IKK [1].
#=GF SQ   215
#=GS G5E140_9PIPI/16-75       AC G5E140.1
#=GS K1Q2D0_CRAGI/51-118      AC K1Q2D0.1
#=GS Q3ZC32_BOVIN/37-104      AC Q3ZC32.1
#=GS Q8VC91_MOUSE/44-111      AC Q8VC91.1
#=GS Q2MH90_RAT/30-97         AC Q2MH90.1
#=GS H2N2R3_ORYLA/37-104      AC H2N2R3.1
#=GS G6D3R2_DANPL/14-81       AC G6D3R2.1
#=GS F1Q438_CANFA/57-124      AC F1Q438.2
#=GS Q7TSS3_MOUSE/62-129      AC Q7TSS3.1
#=GS F6UWD8_HORSE/37-104      AC F6UWD8.1
#=GS Q4SSU6_TETNG/69-122      AC Q4SSU6.1
#=GS H9J3U1_BOMMO/8-75        AC H9J3U1.1
#=GS G5E246_9PIPI/38-94       AC G5E246.1
#=GS G3IBL5_CRIGR/32-99       AC G3IBL5.1
#=GS A3KG41_MOUSE/44-111      AC A3KG41.1
#=GS M7BNP1_CHEMY/66-133      AC M7BNP1.1
#=GS Q4G3H3_DANRE/43-110      AC Q4G3H3.1
#=GS C9JN51_HUMAN/44-111      AC C9JN51.2
#=GS M3XPH7_MUSPF/37-104      AC M3XPH7.1
#=GS G3RQC2_GORGO/1-49        AC G3RQC2.1
#=GS A3KG37_MOUSE/50-117      AC A3KG37.1
#=GS G1MZZ3_MELGA/37-104      AC G1MZZ3.1
#=GS G1P540_MYOLU/37-104      AC G1P540.1
#=GS G3RVA2_GORGO/112-179     AC G3RVA2.1
#=GS A3KG40_MOUSE/44-111      AC A3KG40.1
#=GS F7GMH9_MACMU/44-111      AC F7GMH9.1
#=GS B5X3H2_SALSA/29-96       AC B5X3H2.1
#=GS F1RDV0_DANRE/26-93       AC F1RDV0.1
#=GS G3QQD5_GORGO/112-179     AC G3QQD5.1
#=GS U5EYK8_9DIPT/145-212     AC U5EYK8.1
#=GS S4P2H1_9NEOP/14-81       AC S4P2H1.1
#=GS G8JLS4_RAT/37-104        AC G8JLS4.1
#=GS A1L2U3_XENLA/31-98       AC A1L2U3.1
#=GS B7ZA56_HUMAN/1-47        AC B7ZA56.1
#=GS D6W9Q5_TRICA/104-171     AC D6W9Q5.1
#=GS F1M9C4_RAT/37-104        AC F1M9C4.1
#=GS B0KWU0_CALJA/44-111      AC B0KWU0.1
#=GS E2RBP8_CANFA/45-112      AC E2RBP8.2
#=GS T1DJV3_CROHD/37-104      AC T1DJV3.1
#=GS W5P1P1_SHEEP/38-105      AC W5P1P1.1
#=GS B2KIK6_RHIFE/44-111      AC B2KIK6.1
#=GS I3MGM9_SPETR/50-117      AC I3MGM9.1
#=GS H2N9S6_PONAB/37-104      AC H2N9S6.1
#=GS W5LEZ0_ASTMX/43-110      AC W5LEZ0.1
#=GS Q58EN3_DANRE/43-110      AC Q58EN3.1
#=GS U3IAG4_ANAPL/37-104      AC U3IAG4.1
#=GS Q0ZDL5_SALSA/29-96       AC Q0ZDL5.1
#=GS G3Q620_GASAC/36-103      AC G3Q620.1
#=GS G6DE28_DANPL/84-151      AC G6DE28.1
#=GS U3BKY3_CALJA/37-104      AC U3BKY3.1
#=GS S9WAZ5_9CETA/32-99       AC S9WAZ5.1
#=GS W5UL35_ICTPU/43-110      AC W5UL35.1
#=GS F6UWH6_HORSE/37-104      AC F6UWH6.1
#=GS K7GC11_PELSI/37-96       AC K7GC11.1
#=GS C3YPU4_BRAFL/78-145      AC C3YPU4.1
#=GS W5NAA1_LEPOC/36-103      AC W5NAA1.1
#=GS OPTN_MACMU/37-104        AC Q861Q8.1
#=GS K7FYA9_PELSI/43-110      AC K7FYA9.1
#=GS F7BJ31_CIOIN/30-97       AC F7BJ31.1
#=GS OPTN_XENLA/31-98         AC Q5M7B7.1
#=GS H3A533_LATCH/18-85       AC H3A533.1
#=GS T0B9Q9_9BACI/18-65       AC T0B9Q9.1
#=GS H2L9T8_ORYLA/1-49        AC H2L9T8.1
#=GS NEMO_MOUSE/44-111        AC O88522.2
#=GS F1QHG7_DANRE/43-110      AC F1QHG7.1
#=GS S7NAS1_MYOBR/37-104      AC S7NAS1.1
#=GS F7GML8_MACMU/44-111      AC F7GML8.1
#=GS OPTN_PONAB/37-104        AC Q5R923.1
#=GS S5Y7I1_HORSE/44-111      AC S5Y7I1.1
#=GS D2I3B5_AILME/48-115      AC D2I3B5.1
#=GS F7GMH3_MACMU/44-111      AC F7GMH3.1
#=GS G7PED9_MACFA/37-104      AC G7PED9.1
#=GS H2R099_PANTR/37-104      AC H2R099.1
#=GS A5WUQ0_DANRE/19-86       AC A5WUQ0.1
#=GS G3PIJ0_GASAC/28-95       AC G3PIJ0.1
#=GS G1RNU9_NOMLE/37-104      AC G1RNU9.1
#=GS L8HS51_9CETA/48-115      AC L8HS51.1
#=GS C9J2V2_HUMAN/32-99       AC C9J2V2.1
#=GS E2B714_HARSA/95-162      AC E2B714.1
#=GS K7GRB1_PIG/44-111        AC K7GRB1.1
#=GS W5NAA3_LEPOC/38-105      AC W5NAA3.1
#=GS K7GBZ3_PELSI/37-96       AC K7GBZ3.1
#=GS F6R1Z3_MONDO/97-164      AC F6R1Z3.2
#=GS H2RI27_PANTR/112-179     AC H2RI27.1
#=GS H3CN64_TETNG/1-67        AC H3CN64.1
#=GS T1JEL1_STRMM/69-136      AC T1JEL1.1
#=GS M3YEK4_MUSPF/44-111      AC M3YEK4.1
#=GS H2RZL3_TAKRU/15-82       AC H2RZL3.1
#=GS OPTN_DANRE/19-86         AC Q5RI56.2
#=GS K7GSV8_PIG/44-111        AC K7GSV8.1
#=GS H9KJ83_APIME/116-183     AC H9KJ83.1
#=GS B4E184_HUMAN/1-47        AC B4E184.1
#=GS U3FC05_MICFL/19-86       AC U3FC05.1
#=GS G5BE21_HETGA/37-104      AC G5BE21.1
#=GS H3A890_LATCH/36-103      AC H3A890.1
#=GS G1RVV7_NOMLE/44-111      AC G1RVV7.1
#=GS S7Q9Q8_MYOBR/32-99       AC S7Q9Q8.1
#=GS W5LAG8_ASTMX/36-103      AC W5LAG8.1
#=GS E7EU78_HUMAN/44-111      AC E7EU78.1
#=GS V9KH70_CALMI/19-86       AC V9KH70.1
#=GS K7JGS3_NASVI/118-185     AC K7JGS3.1
#=GS OPTN_PIG/37-104          AC Q7YS99.1
#=GS NEMO_HUMAN/44-111        AC Q9Y6K9.2
#=GS NEMO_HUMAN/44-111        DR PDB; 3BRT B; 49-109;
#=GS NEMO_HUMAN/44-111        DR PDB; 3BRV D; 49-110;
#=GS NEMO_HUMAN/44-111        DR PDB; 3BRT D; 49-110;
#=GS NEMO_HUMAN/44-111        DR PDB; 3BRV B; 49-109;
#=GS V5GH89_ANOGL/14-81       AC V5GH89.1
#=GS G1STZ8_RABIT/45-112      AC G1STZ8.1
#=GS G3UCW2_LOXAF/37-104      AC G3UCW2.1
#=GS F7AMM1_CALJA/54-121      AC F7AMM1.1
#=GS M3X2Y1_FELCA/32-99       AC M3X2Y1.1
#=GS H9FNG7_MACMU/37-104      AC H9FNG7.1
#=GS U6DAH7_NEOVI/37-104      AC U6DAH7.1
#=GS G3TTB2_LOXAF/49-116      AC G3TTB2.1
#=GS NEMO_RAT/44-111          AC Q6TMG5.1
#=GS A9CB72_PAPAN/44-111      AC A9CB72.1
#=GS U3JGS6_FICAL/37-104      AC U3JGS6.1
#=GS L5L0Z9_PTEAL/37-104      AC L5L0Z9.1
#=GS Q58EP1_DANRE/43-110      AC Q58EP1.1
#=GS OPTN_HUMAN/37-104        AC Q96CV9.2
#=GS F6WK94_MACMU/37-104      AC F6WK94.1
#=GS U6CY78_NEOVI/44-111      AC U6CY78.1
#=GS A3KG38_MOUSE/56-123      AC A3KG38.1
#=GS U3B2U7_CALJA/37-104      AC U3B2U7.1
#=GS H3A892_LATCH/35-102      AC H3A892.1
#=GS R0JWC0_ANAPL/37-104      AC R0JWC0.1
#=GS OPTN_CHICK/37-104        AC Q90Z16.1
#=GS F6TK31_HORSE/50-117      AC F6TK31.1
#=GS V5GU80_ANOGL/138-205     AC V5GU80.1
#=GS G3TB30_LOXAF/37-104      AC G3TB30.1
#=GS G3RFJ6_GORGO/37-104      AC G3RFJ6.1
#=GS F7DVK0_XENTR/33-100      AC F7DVK0.1
#=GS F6T3V5_CALJA/44-111      AC F6T3V5.1
#=GS E2A3H8_CAMFO/95-162      AC E2A3H8.1
#=GS F6Z6G3_XENTR/31-98       AC F6Z6G3.1
#=GS I3K179_ORENI/15-82       AC I3K179.1
#=GS NEMO_BOVIN/44-111        AC Q95KU9.1
#=GS L5L5S8_PTEAL/19-86       AC L5L5S8.1
#=GS A9QT41_PIG/44-111        AC A9QT41.1
#=GS G7N1L3_MACMU/37-104      AC G7N1L3.1
#=GS F7I7M0_CALJA/37-104      AC F7I7M0.1
#=GS V5GLZ6_IXORI/61-129      AC V5GLZ6.1
#=GS F4WV63_ACREC/88-155      AC F4WV63.1
#=GS K7CAG5_PANTR/37-104      AC K7CAG5.1
#=GS F8W9A9_HUMAN/44-111      AC F8W9A9.1
#=GS G3Q622_GASAC/15-82       AC G3Q622.1
#=GS H0WAZ4_CAVPO/45-112      AC H0WAZ4.1
#=GS M3ZQ85_XIPMA/28-95       AC M3ZQ85.1
#=GS W5P590_SHEEP/37-104      AC W5P590.1
#=GS H2PXA1_PONAB/112-179     AC H2PXA1.2
#=GS M7AGA5_CHEMY/1-41        AC M7AGA5.1
#=GS K7GK94_PIG/44-111        AC K7GK94.1
#=GS D2HSV8_AILME/37-104      AC D2HSV8.1
#=GS F7ADE2_MONDO/44-111      AC F7ADE2.2
#=GS H0XPP3_OTOGA/45-112      AC H0XPP3.1
#=GS H2ZF39_CIOSA/39-85       AC H2ZF39.1
#=GS J9P891_CANFA/44-111      AC J9P891.1
#=GS B7NZR1_RABIT/44-111      AC B7NZR1.1
#=GS G1M4E5_AILME/37-104      AC G1M4E5.1
#=GS H0YVJ9_TAEGU/11-78       AC H0YVJ9.1
#=GS H3A891_LATCH/36-103      AC H3A891.1
#=GS G3GVQ4_CRIGR/87-154      AC G3GVQ4.1
#=GS A0A024DBL2_MYTGA/66-133  AC A0A024DBL2.1
#=GS C9JH59_HUMAN/44-111      AC C9JH59.2
#=GS M4A2F1_XIPMA/22-89       AC M4A2F1.1
#=GS H0WGU6_OTOGA/37-104      AC H0WGU6.1
#=GS K9ITG9_DESRO/49-116      AC K9ITG9.1
#=GS H2RZL4_TAKRU/28-95       AC H2RZL4.1
#=GS X6RKL2_HUMAN/1-47        AC X6RKL2.1
#=GS G3VKD7_SARHA/44-111      AC G3VKD7.1
#=GS G1QA20_MYOLU/43-110      AC G1QA20.1
#=GS G1SRQ8_RABIT/1-61        AC G1SRQ8.2
#=GS W4VST2_ATTCE/89-155      AC W4VST2.1
#=GS H2TNH3_TAKRU/32-99       AC H2TNH3.1
#=GS I3IVM4_ORENI/28-95       AC I3IVM4.1
#=GS G9KEN4_MUSPF/37-104      AC G9KEN4.1
#=GS B1H373_XENTR/31-98       AC B1H373.1
#=GS M3W172_FELCA/37-104      AC M3W172.1
#=GS A8MV29_HUMAN/44-111      AC A8MV29.2
#=GS C9JCG6_HUMAN/44-111      AC C9JCG6.1
#=GS A3KG39_MOUSE/44-111      AC A3KG39.1
#=GS E9Q2Y3_MOUSE/56-123      AC E9Q2Y3.1
#=GS L8I0B0_9CETA/37-104      AC L8I0B0.1
#=GS E9GHY3_DAPPU/22-96       AC E9GHY3.1
#=GS H2RZL1_TAKRU/28-95       AC H2RZL1.1
#=GS B0K002_XENTR/33-100      AC B0K002.1
#=GS W5NFE0_LEPOC/36-103      AC W5NFE0.1
#=GS OPTN_MOUSE/37-104        AC Q8K3K8.1
#=GS K7DFS1_PANTR/37-104      AC K7DFS1.1
#=GS F7GWR3_MACMU/44-111      AC F7GWR3.1
#=GS B0LXP7_PIG/44-111        AC B0LXP7.1
#=GS H3A532_LATCH/43-113      AC H3A532.1
#=GS OPTN_RAT/37-104          AC Q8R5M4.3
#=GS L8YA06_TUPCH/44-111      AC L8YA06.1
#=GS B1MTU0_CALMO/44-111      AC B1MTU0.1
#=GS G1KMI1_ANOCA/19-86       AC G1KMI1.1
#=GS L9KQB2_TUPCH/37-104      AC L9KQB2.1
#=GS C9J1R1_HUMAN/44-111      AC C9J1R1.1
#=GS B3RFE3_SORAR/44-110      AC B3RFE3.1
#=GS G5BFL6_HETGA/1-51        AC G5BFL6.1
#=GS F7DZC7_ORNAN/44-111      AC F7DZC7.1
#=GS E0VHH6_PEDHC/70-137      AC E0VHH6.1
#=GS H2RZL2_TAKRU/28-95       AC H2RZL2.1
#=GS K9IYQ6_DESRO/37-104      AC K9IYQ6.1
#=GS OPTN_MACFA/37-104        AC Q95KA2.2
#=GS H0VAE0_CAVPO/37-104      AC H0VAE0.1
#=GS Q3UG24_MOUSE/56-123      AC Q3UG24.1
#=GS G1K9C2_ANOCA/37-104      AC G1K9C2.2
#=GS V9IHK1_APICE/116-183     AC V9IHK1.1
#=GS V9KNM2_CALMI/51-126      AC V9KNM2.1
#=GS F6UET8_ORNAN/37-104      AC F6UET8.2
#=GS K7GQV6_PIG/44-111        AC K7GQV6.1
#=GS F7GMH1_MACMU/112-179     AC F7GMH1.1
#=GS V8NHC0_OPHHA/37-104      AC V8NHC0.1
#=GS F7ASB3_CALJA/49-116      AC F7ASB3.1
#=GS H2TNH4_TAKRU/1-66        AC H2TNH4.1
#=GS Q58EW6_XENLA/33-100      AC Q58EW6.1
#=GS F1QHM5_DANRE/43-110      AC F1QHM5.1
G5E140_9PIPI/16-75                  ......DAEMLEQIKQLLHENNNLK...ETMKQ...MNQGMKERLEELLKRHNQ...RLV.DLNSENELLRKELH---------s..........
K1Q2D0_CRAGI/51-118                 ....le--QALDRIQELHRENNELR...DYLKD...NNEKMKLQYQNLSEWKEK...IRV.NNARNKEKFDQTKEVVQTMTREN...........
Q3ZC32_BOVIN/37-104                 ......PHELLQQMRELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLYFETQSKEAKERLTALSLEN...........
Q8VC91_MOUSE/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
Q2MH90_RAT/30-97                    ......PEELLQQMKELLVENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQLFEIQSKEAKERLKALSHEN...........
H2N2R3_ORYLA/37-104                 .....l-EETLQQMNILIQENRDLK...EALRQ...TNLTMKERFEGLSAWREK...QKQ.ERDFLENQLKEAQRNMES-----vvgqn......
G6D3R2_DANPL/14-81                  ....te--ELQKRFGDLLDENFVLK...ETLKQ...NNDSMKEQFILIASCQED...MLK.THRLHKEKFDETRELVERLRQEN...........
F1Q438_CANFA/57-124                 ......EQGTPETYQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRK.EKEFLMQKFQEARKLVERLSLEK...........
Q7TSS3_MOUSE/62-129                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
F6UWD8_HORSE/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
Q4SSU6_TETNG/69-122                 .rllca-------------------...ESLRQ...TNLMMKDRFEDLAVWREK...QRG.ERDILERQLEEARVHMEALTHQ-n..........
H9J3U1_BOMMO/8-75                   .....t-EELQKRFGELLDENLILK...ETLKQ...NNDSMKEQFLLIASCQED...MMK.THMLHKEKFEETKELVERLRQEN...........
G5E246_9PIPI/38-94                  ....el--ATHEVFQRILAENQDLR...TALEQ...SNLMLRKGHSEILEFQET...QKR.EREFIAIKFGEA-----------...........
G3IBL5_CRIGR/32-99                  ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
A3KG41_MOUSE/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
M7BNP1_CHEMY/66-133                 ......PEEMVQQMKELITENNELK...EAMKI...HNQAMKDRYEELSVWREK...QKE.EREFYESKFKEAKHYLQVKCLEN...........
Q4G3H3_DANRE/43-110                 ....dl--AGNEIVQKLITDNHQLR...EALKR...SNDALKERCEEMEGWQRR...SRE.EREFLSCRFREARELVQRLAQEN...........
C9JN51_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
M3XPH7_MUSPF/37-104                 ......PEELLRQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
G3RQC2_GORGO/1-49                   ......-------------------...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCRFQEARKLVERLSLEK...........
A3KG37_MOUSE/50-117                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
G1MZZ3_MELGA/37-104                 ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKDRYEELSIWREK...QKE.EREFYEAKFKEAKQCLLAKCIEN...........
G1P540_MYOLU/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFQELSAWTEK...QKE.ERHFFEIQSKEAKERLMAVSHEN...........
G3RVA2_GORGO/112-179                .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCRFQEARKLVERLSLEK...........
A3KG40_MOUSE/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
F7GMH9_MACMU/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
B5X3H2_SALSA/29-96                  .....l-EETLQQMNRLIQENRDLK...EALKQ...TNMSMKERFEGLSVWREK...QRE.EKEFLEGRLDEARGRMEALSSHN...........
F1RDV0_DANRE/26-93                  .....l-EETLQQMNTLIKENRDLK...EALKQ...TNLSMKERFEGLSAWKEK...QKE.ERDFLEQRLEEARTRLNTMDVEN...........
G3QQD5_GORGO/112-179                .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCRFQEARKLVERLSLEK...........
U5EYK8_9DIPT/145-212                ...sns---EVQQLQTLMKENLQLK...ENLQK...SNLQMRKNFVEMQKWQND...VKV.DRAKHLELIQESKKAIEELQSTN...........
S4P2H1_9NEOP/14-81                  .....t-EELQKRFGELLDENVVLK...ETLKQ...NNDSMKEQFMLIASCQED...MLK.THRLHKEKFDETRELVERLRQEN...........
G8JLS4_RAT/37-104                   ......PEELLQQMKELLVENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQLFEIQSKEAKERLKALSHEN...........
A1L2U3_XENLA/31-98                  ......DAEMLEQIKQLLMENNNLK...ETMKQ...MNQEMKERLEVLLKRHNQ...HLL.DLKSENEVLRKELQCLKERNAT-y..........
B7ZA56_HUMAN/1-47                   ......-------------------...--MKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
D6W9Q5_TRICA/104-171                .....y-EEIQKQVEELIKENEKLK...NIIAQ...NNMSMKAQYTRFLAYRDE...VTN.VMKSYKDKFNDAKMCIDKYKEEN...........
F1M9C4_RAT/37-104                   ......PEELLQQMKELLVENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQLFEIQSKEAKERLKALSHEN...........
B0KWU0_CALJA/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
E2RBP8_CANFA/45-112                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLYFEVQSKEAKERLMALSHEN...........
T1DJV3_CROHD/37-104                 .....v-EEMVQQMKELITENNELK...EAMRQ...RNQAMKDRFEELSAWKEK...LKE.EREFYESKFKDARQCLAAKCLEN...........
W5P1P1_SHEEP/38-105                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGN...QRE.EKAFLMQKFQEARDLVARLSLEK...........
B2KIK6_RHIFE/44-111                 .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRECCEELQRFQGN...QRE.EKEFLMQRFQEARSLVERLSLEK...........
I3MGM9_SPETR/50-117                 .....e-QGIPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMHKFQEARKLVERLSLEK...........
H2N9S6_PONAB/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
W5LEZ0_ASTMX/43-110                 ....el--AGNEVVHRLLADNHQLR...EALKR...SNDALKDRCEEMEGWQRR...SRE.EREFLSCKFREARALVERLAQEN...........
Q58EN3_DANRE/43-110                 ....dl--AGNEIVQKLITDNHQLR...EALKR...SNDALKERCEEMEGWQRR...SRE.EREFLSCRFREARELVQRLAQEN...........
U3IAG4_ANAPL/37-104                 ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKERYEELSIWREK...QKE.EREFYETKFKEAKQCLLAKCVEN...........
Q0ZDL5_SALSA/29-96                  .....l-EETLQQMNHLIQENRDLK...EALKQ...TNMSMKERFEGLSVWREK...QRE.EKEFLEGRLDEACGLVEALSSHN...........
G3Q620_GASAC/36-103                 .....l-EETLQQMNILIQENRDLK...EALRQ...TNLMMKDRFEGLSAWREK...QRE.ERDFLENKLEDARGRMEALTLQN...........
G6DE28_DANPL/84-151                 ....te--ELQKRFGDLLDENFVLK...ETLKQ...NNDSMKEQFILIASCQED...MLK.THRLHKEKFDETRELVERLRQEN...........
U3BKY3_CALJA/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSQEN...........
S9WAZ5_9CETA/32-99                  ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRLQGS...QRE.EKEFLMQKFQEARKLVERLSLEK...........
W5UL35_ICTPU/43-110                 ..elpg----HEVVNRLLLDNHQLR...EALRR...SNDALKNRCEEMEGWQRR...SRE.EREFLSGRFHEARALVERLAQEN...........
F6UWH6_HORSE/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
K7GC11_PELSI/37-96                  ......PEEMVQQMKELITENNELK...EAMKI...HNQAMKGRYEELSVWREK...Q--.------TKFKEAKHCLQAKCLEN...........
C3YPU4_BRAFL/78-145                 ....ag--EMQSYMTELLKDNNSLR...DTIRQ...NNEDMRQKIKDLEVWKEK...QKQ.NQALIVGKFTEAREKVLSLRKEN...........
W5NAA1_LEPOC/36-103                 ....el--AGNEIVQRLLAENQDLR...DAIRQ...SNQALRDRYEEMLSFRLK...NRQ.ERQFLMEKFREARELVERLSREN...........
OPTN_MACMU/37-104                   ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
K7FYA9_PELSI/43-110                 ....el--AGHEALQRFLLENQDLK...EAIRQ...SNQMLRQRYQEFVGFQAV...QRE.EKDFLLLRFREARDVVQKLNAE-r..........
F7BJ31_CIOIN/30-97                  ..nsml----SQLLDNLITGNQDLK...QTIKV...NNEELYSKCESLLKWKKD...VDD.KVKKLFDTCDRARVKVQS-----mkeqn......
OPTN_XENLA/31-98                    ......DAEMLEQIKQLLMENNNLK...ETMKQ...MNQEMKERLEELLKRHNQ...HLL.DLNSANEVLRKELQSLKEKIA--ts.........
H3A533_LATCH/18-85                  ...eln---SQEALQRLQAENYDLR...EAMRQ...SNLALRERYDELLAFRAR...NKE.EKDFMLERFKEARCLVEKLSQEK...........
T0B9Q9_9BACI/18-65                  ...vqq---QKQLIHQLIQENEHLR...QDIKQlrkENEQLKDRIQELEAHTKK...QL-.-----------------------q..........
H2L9T8_ORYLA/1-49                   ......-------------------...EALRR...SNQALRLRCEEMEGWQQR...TRD.EREFLSCRFQEARALVERLAQEN...........
NEMO_MOUSE/44-111                   ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
F1QHG7_DANRE/43-110                 ....dl--AGNEIVQKLITDNHQLR...EALKR...SNDALKERCEEMEGWQRR...SRE.EREFLSCRFREARELVQRLAQEN...........
S7NAS1_MYOBR/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFQELSAWTEK...QKE.ERHFFEIQSKEAKERLMAVSHEN...........
F7GML8_MACMU/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
OPTN_PONAB/37-104                   ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
S5Y7I1_HORSE/44-111                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQHFQSS...QRE.EKEFLMQKFQEARKLVERLSLEK...........
D2I3B5_AILME/48-115                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRK.EKEFLMQKFQEARKLVERLSLEK...........
F7GMH3_MACMU/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
G7PED9_MACFA/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
H2R099_PANTR/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
A5WUQ0_DANRE/19-86                  .....l-EETLQQMNTLIKENRDLK...EALKQ...TNLSMKERFEGLSAWKEK...QKE.ERDFLEQRLEEARTRLNTMDVEN...........
G3PIJ0_GASAC/28-95                  ....el--ASNEVVTRLLGDNQQLR...EALRR...SNVALRQRCEEMEGWQQR...TRD.EREFLSCRFQEARALVERLAQEN...........
G1RNU9_NOMLE/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
L8HS51_9CETA/48-115                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGN...QRE.EKAFLMQKFQEARDLVVRLSLEK...........
C9J2V2_HUMAN/32-99                  .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
E2B714_HARSA/95-162                 ....in--ETHKKLTELLQENTKLK...ETLKQ...NSLAMKKQLSTMASWQGI...VMK.LHENHKKKFKETTDLINNLKREN...........
K7GRB1_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
W5NAA3_LEPOC/38-105                 ....el--AGNEIVQRLLAENQDLR...DAIRQ...SNQALRDRYEEMLSFRLK...NRQ.ERQFLMEKFREARELVERLSREN...........
K7GBZ3_PELSI/37-96                  ......PEEMVQQMKELITENNELK...EAMKI...HNQAMKGRYEELSVWREK...Q--.------TKFKEAKHCLQAKCLEN...........
F6R1Z3_MONDO/97-164                 ......PEEMLKQMKELLIENHQLK...EAMKL...NNQTMKGRFEELSAWTEK...QKE.ERQCFELKFKEVKENLLSLSNEN...........
H2RI27_PANTR/112-179                .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQCCGKRCEEVLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
H3CN64_TETNG/1-67                   ......-EETLHQMNILIQENRDLK...ESLRQ...TNLMMKDRFEDLAVWREK...QRG.ERDILERQLEEARVHMEALTHQ-n..........
T1JEL1_STRMM/69-136                 ....pd--EIQTRLRDLLNENLELK...ETLHE...NNAAMSEQFGRLSQWQKE...VEF.AQSQNKVKFEESRDLIGKLREEN...........
M3YEK4_MUSPF/44-111                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQVLRERCEELQRFQGS...QRK.EKEFLVQKFQEARKLVERLSLEK...........
H2RZL3_TAKRU/15-82                  ....el--AANEVFTRLLSDNQQLR...ETLRR...SNLALRQRCEEMEGWQRR...SRE.DREFLSCRFQEARALVERLAEK-n..........
OPTN_DANRE/19-86                    .....l-EETLQQMNTLIKENRDLK...EALKQ...TNLSMKERFEGLSAWKEK...QKE.ERDFLEQRLEEARTRLNTMDVEN...........
K7GSV8_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
H9KJ83_APIME/116-183                .....t-AEVHQKLNELLQENTKLK...ETLKQ...NNIAMKQQFNVLATWQEE...IMR.VHQNHKKKFAETRELINYLKKEN...........
B4E184_HUMAN/1-47                   ......-------------------...--MKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
U3FC05_MICFL/19-86                  ....el--AGHEAVQYFLAENRDLK...EAIRQ...SNHMLRERYQEFVQFHAS...KKE.EKEFIMSKFQEARHVVEKMHME-r..........
G5BE21_HETGA/37-104                 ......PEELLQQMKELLAENHQLK...EAMKL...NNQAMKGRFEELSAWTER...QKE.ERQFFEMQSKEAKERLMALSHEN...........
H3A890_LATCH/36-103                 ......PEETLQQIQELIKENGELK...EAVKQ...TNQAMKERYDELSAWRGR...QKE.EREFLERKFQEAKEKLLALTKEN...........
G1RVV7_NOMLE/44-111                 .....e-HGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
S7Q9Q8_MYOBR/32-99                  .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRECCEELQRFQGS...QRE.EKEFLMQKFQEARKLVERLNLEK...........
W5LAG8_ASTMX/36-103                 .....v-EETLQQMNILIKENRELK...EALKQ...TNLSMKERFEGLTVWKEK...QKE.ERSFLESRLEEARQRVHALDSEN...........
E7EU78_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
V9KH70_CALMI/19-86                  ......PEEALQQMQELIKENNELK...EAIKQ...TNHAMKERYEELATWREK...QRE.EREYIQKKFEEAKKRLADLTAEN...........
K7JGS3_NASVI/118-185                .....p-SEIEEKLKNVLEENIKLK...ETLKQ...NNSATKQQFNTITMWQKD...VMT.VCDNHKQKFMETKQLMSRLKKEN...........
OPTN_PIG/37-104                     ......PHELLQQMRELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFETQSKEAKERLTALSLEN...........
NEMO_HUMAN/44-111                   .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
#=GR NEMO_HUMAN/44-111        SS    .....X-XXXX-HHHHHHHHHHHHH...HHHHH...HHHHHHHHHHHHHHHHHH...HHH.HHHHHHHHHHHHHHHHHHHHCXX...........
V5GH89_ANOGL/14-81                  .....p-AELEKKVSEIVEENIRLK...DTVLG...NNKTMKMQYDRIVKWQSD...VQK.VHQTHKEKIIEAKEFIERLKKEN...........
G1STZ8_RABIT/45-112                 .....e-QGAPDALQRCLEENQELR...DAIRQ...SNQMLRERCEELLRFQVS...QRE.EKEFLLCKFQEARKLVERLNLEK...........
G3UCW2_LOXAF/37-104                 ......PEELLQQMKELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLIALSHEN...........
F7AMM1_CALJA/54-121                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
M3X2Y1_FELCA/32-99                  ......EQGTPETFQRCVEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRK.EKEFLMQKFQEARKLVERLSLEK...........
H9FNG7_MACMU/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
U6DAH7_NEOVI/37-104                 ......PEELLRQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
G3TTB2_LOXAF/49-116                 .....e-QGASEPLQRCLEENQELR...DAFRE...SNQMLRERCEELLHFQVS...QRE.EKEFLMQKFQEARKLVEKLSLEK...........
NEMO_RAT/44-111                     ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
A9CB72_PAPAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
U3JGS6_FICAL/37-104                 ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKDRYEELSTWREK...QKE.EREFYELKFKEAKQCLQAKCIEN...........
L5L0Z9_PTEAL/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
Q58EP1_DANRE/43-110                 ....dl--AGNEIVQKLITDNHQLR...EALKR...SNDALKERCEEMEGWQRR...SRE.EREFLSCRFREARELVQRLAQEN...........
OPTN_HUMAN/37-104                   ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
F6WK94_MACMU/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
U6CY78_NEOVI/44-111                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQVLRERCEELQRFQGS...QRK.EREFLVQKFQEARKLVERLSLEK...........
A3KG38_MOUSE/56-123                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
U3B2U7_CALJA/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSQEN...........
H3A892_LATCH/35-102                 ......PEETLQQIQELIKENGELK...EAVKQ...TNQAMKERYDELSAWRAK...EKLlALTKENEELKK------------tvqiqeekhqk
R0JWC0_ANAPL/37-104                 ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKERYEELSIWREK...QKE.EREFYETKFKEAKQCLLAKCVEN...........
OPTN_CHICK/37-104                   ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKDRYEELSIWREK...QKE.EREFYETKFKEAKQCLLAKCVEN...........
F6TK31_HORSE/50-117                 ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQHFQSS...QRE.EKEFLMQKFQEARKLVERLSLEK...........
V5GU80_ANOGL/138-205                ...seq---VQKKVSEIVEENIRLK...DTILQ...NNMSMKSQYERIVAWQED...VQK.VHQAHKEKIIEAKEFIEKLKKEN...........
G3TB30_LOXAF/37-104                 ......PEELLQQMKELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLIALSHEN...........
G3RFJ6_GORGO/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
F7DVK0_XENTR/33-100                 ...elt---SNEAFQRIWAENHDLR...AALEQ...SNMMLRKGHGDMLEFQDS...QRK.EREFITYKFGEARDLVLRLTNE-r..........
F6T3V5_CALJA/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
E2A3H8_CAMFO/95-162                 .....t-DEMQKKLSDMLQENVKLK...ETLKQ...NTLSMKEQFSTLAMWQEE...VMK.VHENHKKKFAETRELINHLKKEN...........
F6Z6G3_XENTR/31-98                  ......DAEMLEQIKQLLMENNNLK...ETMKQ...MNQEMKERLEELLKRHNQ...HLL.DLNSENELLRKELNSLREKNAT-s..........
I3K179_ORENI/15-82                  .....l-EETLQQMNILIQENRDLK...EALRQ...TNLTMKERFEGLSAWREK...QKE.ERDFLESRLEEARGRMEALTLQN...........
NEMO_BOVIN/44-111                   ......EQGTPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQHFQGN...QRE.EKAFLMQKFQEARDLVVRLSLEK...........
L5L5S8_PTEAL/19-86                  .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRECCEELQRFQGN...QRE.EKQFLMQKFQEARKLVERLSVEK...........
A9QT41_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
G7N1L3_MACMU/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
F7I7M0_CALJA/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSQEN...........
V5GLZ6_IXORI/61-129                 ....ld--EAEQCVRDLLRENKELK...DVLVQ...NSQKLREQYETFVDWKQQlsrAHE.QHRQALERLQGEKEAL-------aaqad......
F4WV63_ACREC/88-155                 ....vt--AMQDRLVEVLQENVKLK...ETLRQ...TNVSMKQHFNTLTMWQEE...VTK.VHLSHKQQFAETKELINHLKKEN...........
K7CAG5_PANTR/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
F8W9A9_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
G3Q622_GASAC/15-82                  .....l-EETLQQMNILIQENRDLK...EALRQ...TNLMMKDRFEGLSAWREK...QRE.ERDFLENKLEDARGRMEALTLQN...........
H0WAZ4_CAVPO/45-112                 .....e-QGSPEALQHCLEENHELR...DAIRQ...NNQMLRERCEELLHFQAS...QKE.EREFLMCKFQEARKLVERLSLEK...........
M3ZQ85_XIPMA/28-95                  ....el--AGNEVVTRLLGDNQQLR...EALRR...SNQALRQRCEEMEGWQRR...TRE.EREFLSCRFQEARALVERLAQEN...........
W5P590_SHEEP/37-104                 ......PHELLQQMRELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLYFETQSKEAKERLTALSLEN...........
H2PXA1_PONAB/112-179                .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
M7AGA5_CHEMY/1-41                   ......-------------------...-----...---MLRQRYQEFLRFQAT...QRE.EKEFLMLRFREARDVVEKLNTE-r..........
K7GK94_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
D2HSV8_AILME/37-104                 ......PEELLQQMKELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTER...QKE.ERLFFETQSKEAKERLMALSHEN...........
F7ADE2_MONDO/44-111                 ..sqvs----PEALQRFLEENQELR...DALRQ...SNQMLRERYQEFVNFQAN...QKE.EKEFLMRKFQEARTLVEKLKTEK...........
H0XPP3_OTOGA/45-112                 ......EQGTPETLQRCVEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKAFLTHKFQEARKLVERLSLEK...........
H2ZF39_CIOSA/39-85                  ...htm---LNQLLSKLITGNNDLK...QTIRV...NNQQLHDKCNALVQWKA-...---.-----------------------nvdrsv.....
J9P891_CANFA/44-111                 ......EQGTPETYQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRK.EKEFLMQKFQEARKLVERLSLEK...........
B7NZR1_RABIT/44-111                 .....e-QGAPDALQRCLEENQELR...DAIRQ...SNQMLRERCEELLRFQVS...QRE.EKEFLLCKFQEARKLVERLNLEK...........
G1M4E5_AILME/37-104                 ......PEELLQQMKELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTER...QKE.ERLFFETQSKEAKERLMALSHEN...........
H0YVJ9_TAEGU/11-78                  ......PEEMVQQMKELITENNELK...EAMKL...HNQAMKDRYEELSTWREK...QKE.EREFYELKFKEAKQCLQAKCIEN...........
H3A891_LATCH/36-103                 ......PEETLQQIQELIKENGELK...EAVKQ...TNQAMKERYDELSAWRGR...QKE.EREFLERKFQEAKEKLLALTKEN...........
G3GVQ4_CRIGR/87-154                 ......PEEMLQQMKELLVENHQLK...EAMKL...NNQAMKGRYEELSAWAEK...QKE.ERQLFDTQNKEAKKLLMTLSYEN...........
A0A024DBL2_MYTGA/66-133             ....ae--QALERVQELMKENQSLR...EYLKE...NNAVINNKYQEIADWKER...IKK.YHKHNQEKCEEAKNVILNLRSEN...........
C9JH59_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
M4A2F1_XIPMA/22-89                  .....l-EETVQQMNMLIQENRDLK...EALRQ...TNLTMKERFEGLTAWKEK...QRQ.EKDFLEKRLEEARRCIETLTVQN...........
H0WGU6_OTOGA/37-104                 ......PEELLRQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSREAKQRLMALSHEN...........
K9ITG9_DESRO/49-116                 .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRECCEELQRFQGG...QRE.EKEFLVQKFQEARRLVERLNLEK...........
H2RZL4_TAKRU/28-95                  ....el--AANEVFTRLLSDNQQLR...ETLRR...SNLALRQRCEEMEGWQRR...SRE.DREFLSCRFQEARALVERLA---eks........
X6RKL2_HUMAN/1-47                   ......-------------------...--MKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
G3VKD7_SARHA/44-111                 ...nqv---SPEALQRCLEENQELR...DALRQ...SNHMLRQRYQEFLNFQAN...QKE.EKEFLMQKFQEARKLVEKLNMEK...........
G1QA20_MYOLU/43-110                 .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRECCEELQRFQGS...QRE.EKEFLMQKFQEARKLVERLNLEK...........
G1SRQ8_RABIT/1-61                   ......-------MKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWSEK...QKE.ERQFFELQSKESKERIMALSHEN...........
W4VST2_ATTCE/89-155                 ....ta---MQHRLVEVLQENVKLK...ETLRQ...NNVSMKQQFNTLAMWQEE...VTK.VHLSHKQQFAETKELINHLKKEN...........
H2TNH3_TAKRU/32-99                  .....l-EETLHQMNILIQENRDLK...ESLRQ...TNLAMKERFEGLAAWREK...QRE.ERDFLESRLKEARDRMEALTCQN...........
I3IVM4_ORENI/28-95                  ....el--AANEVVTRLLSDNQQLR...EALRR...SNLALRQRCEEMEGWQRR...TKE.EREFLSCRFQEARSLVERLAQEN...........
G9KEN4_MUSPF/37-104                 ......PEELLRQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLMALSHEN...........
B1H373_XENTR/31-98                  ......DAEMLEQIKQLLMENNNLK...ETMKQ...MNQEMKERLEELLKRHNQ...HLL.DLNSENELLRKELNSLREKNAT-s..........
M3W172_FELCA/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLFFEIQSKEAKERLVALSHEN...........
A8MV29_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
C9JCG6_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
A3KG39_MOUSE/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
E9Q2Y3_MOUSE/56-123                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
L8I0B0_9CETA/37-104                 ......PHELLQQMRELLIENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLYFETQSKEAKERLTALSLEN...........
E9GHY3_DAPPU/22-96                  .....v-EEIEEKIQTLITENTGLR...NTLQQ...NNTYMRQLSSTLVEWQEE...VIR.VQSVYQNKVERAKEVITKLKEENaalkeki....
H2RZL1_TAKRU/28-95                  ....el--AANEVFTRLLSDNQQLR...ETLRR...SNLALRQRCEEMEGWQRR...SRE.DREFLSCRFQEARALVERLAEEN...........
B0K002_XENTR/33-100                 ...elt---SNEAFQRIWAENHDLR...AALEQ...SNMMLRKGHGDMLEFQDS...QRK.EREFITYKFGEARDLVLRLTNE-r..........
W5NFE0_LEPOC/36-103                 ......PEETLQQMNILIKENSELK...EALKQ...TNTSMKERFEGLAAWKEK...QKE.EREFLENKFLEAKNRVTALTK--rn.........
OPTN_MOUSE/37-104                   ......PEELLQQMKELLVENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERLLFEMQSKEVKERLKALTHEN...........
K7DFS1_PANTR/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
F7GWR3_MACMU/44-111                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
B0LXP7_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
H3A532_LATCH/43-113                 ...eln---SQEALQRLQAENYDLRvipEAMRQ...SNLALRERYDELLAFRAR...NKE.EKDFMLERFKEARCLVEKLSQEK...........
OPTN_RAT/37-104                     ......PEELLQQMKELLVENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQLFEIQSKEAKERLKALSHEN...........
L8YA06_TUPCH/44-111                 .....e-QGIPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLRFQVI...QRE.EKEFLMQKFQEARRLVERLSLEK...........
B1MTU0_CALMO/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
G1KMI1_ANOCA/19-86                  ....el--AGHEAVQHVLAENRDLK...EAIQR...SNHMLRERYREFLQFQAS...HKQ.EKEFLFCKFQEARLLVENLQLE-r..........
L9KQB2_TUPCH/37-104                 ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFELQSKEAKERLIALSHEN...........
C9J1R1_HUMAN/44-111                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQILRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLGLEK...........
B3RFE3_SORAR/44-110                 .....e-HAGPDTFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRVQGG...QRE.EKDFLLHKFRAARALVERLR---ac.........
G5BFL6_HETGA/1-51                   ....ml-------------------...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFIMCKFQEARKLVERLSLEK...........
F7DZC7_ORNAN/44-111                 ....dq--DPQEALQRFLVENQELR...EAIRQ...SNQMLREWYKEFLNFQAN...HKE.EKEFLRRKFQGARNLVERLNLEK...........
E0VHH6_PEDHC/70-137                 ..egda----QDKLNHLLQENQKLK...ETLNQ...NNLAIKSQLNTFFMWQQE...VLK.THETHKQKFLETKDLILKLRLEN...........
H2RZL2_TAKRU/28-95                  ....el--AANEVFTRLLSDNQQLR...ETLRR...SNLALRQRCEEMEGWQRR...SRE.DREFLSCRFQEARALVERLAEEN...........
K9IYQ6_DESRO/37-104                 ......PEELLQQMKELLIENHQLK...EAMKL...NNQAMKGRFQELSAWTEK...QKE.ERLFFETQRKEAKERLMALSHEN...........
OPTN_MACFA/37-104                   ......PEELLQQMKELLTENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFETQSKEAKERLMALSHEN...........
H0VAE0_CAVPO/37-104                 ......PEELLQQMKELLAENHQLK...EAMKL...NNQAMKGRFEELSAWTEK...QKE.ERQFFEIQSKEAKERLMALSHEN...........
Q3UG24_MOUSE/56-123                 ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQVS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
G1K9C2_ANOCA/37-104                 .....v-EEMVQQMKELITENNELK...EAVRQ...HNQAMKDRFENLSEWSEK...LKE.EREFYEIKFKEARQCLASKCVEN...........
V9IHK1_APICE/116-183                .....t-AEVHKKLNELLQENTKLK...ETLKQ...NNIAMKQQFNVLASWQEE...IMR.LHQNHKKKFGETRELINYLKKEN...........
V9KNM2_CALMI/51-126                 slensn--------RELHRENVSLR...NAIRQ...SNQALKERYDELLAFRDR...NRQ.EKEFLMEKFTEARRTVGRLSQDNtelrrrletv.
F6UET8_ORNAN/37-104                 ......PEEMLQQMKELLIENHQLK...EAMKL...NNQAMKGRFEELSAWREK...QKE.ERQFFESKFKEAKERLLALSNEK...........
K7GQV6_PIG/44-111                   .....e-QGAPETFQRCLEENQELR...DAIRQ...SNQMLRERCEELQRFQGS...QRE.EKEFLMQKFCEARRLVERLSLEK...........
F7GMH1_MACMU/112-179                ......EQGTPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
V8NHC0_OPHHA/37-104                 .....v-EEMVQQMKELITENNELK...EAMRQ...RNQAMKERFEELSAWKEK...LKD.EREFYESKFKEARQCLATKCLEN...........
F7ASB3_CALJA/49-116                 .....e-QGAPETLQRCLEENQELR...DAIRQ...SNQMLRERCEELLHFQAS...QRE.EKEFLMCKFQEARKLVERLSLEK...........
H2TNH4_TAKRU/1-66                   ......--ETLHQMNILIQENRDLK...ESLRQ...TNLAMKERFEGLAAWREK...QRE.ERDFLESRLKEARDRMEALTCQN...........
Q58EW6_XENLA/33-100                 ...elt---NNEAFQRIWAENHDLR...GALEQ...SNKMLRKGHSELLEFQES...QRK.EREFITYKFGEARNLVLRLTSE-r..........
F1QHM5_DANRE/43-110                 ....dl--AGNEIVQKLITDNHQLR...EALKR...SNDALKERCEEMEGWQRR...SRE.EREFLSCRFREARELVQRLAQEN...........
#=GC SS_cons                        .....X-XXXX-HHHHHHHHHHHHH...HHHHH...HHHHHHHHHHHHHHHHHH...HHH.HHHHHHHHHHHHHHHHHHHHCXX...........
#=GC seq_cons                       .......pth.pphpclLpENpcL+...-Al+Q...sNQth+cRhEELttappp...Q+E.E+cFh.p+FpEA+chlppLohEp...........
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