GenomeNet

Database: Pfam
Entry: NEMO
LinkDB: NEMO
Original site: NEMO 
#=GF ID   NEMO
#=GF AC   PF11577.3
#=GF DE   NF-kappa-B essential modulator NEMO
#=GF AU   Pollington J
#=GF SE   pdb_3brt
#=GF GA   21.00 21.00;
#=GF TC   21.00 23.10;
#=GF NC   19.90 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18462684
#=GF RT   Structure of a NEMO/IKK-associating domain reveals architecture
#=GF RT   of the interaction site. 
#=GF RA   Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo
#=GF RA   H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A; 
#=GF RL   Structure. 2008;16:798-808.
#=GF DR   INTERPRO; IPR021063;
#=GF CC   NEMO is a regulatory protein which is part of the IKK complex
#=GF CC   along with the catalytic IKKalpha and beta kinases. The IKK
#=GF CC   complex phosphorylates IkappaB targeting it for degradation
#=GF CC   which results in the release of NF-kappaB which initiates the
#=GF CC   inflammatory response, cell proliferation or cell
#=GF CC   differentiation [1]. NEMO activates the IKK complex's activity
#=GF CC   by associating with the unphosphorylated IKK kinase C
#=GF CC   termini.The core domain of NEMO is a dimer which binds to two
#=GF CC   fragments of IKK [1].
#=GF SQ   160
#=GS G5E140_9PIPI/16-75    AC G5E140.1
#=GS Q3ZC32_BOVIN/37-104   AC Q3ZC32.1
#=GS Q8VC91_MOUSE/44-111   AC Q8VC91.1
#=GS Q2MH90_RAT/30-97      AC Q2MH90.1
#=GS H2N2R3_ORYLA/37-104   AC H2N2R3.1
#=GS G6D3R2_DANPL/14-81    AC G6D3R2.1
#=GS Q7TSS3_MOUSE/62-129   AC Q7TSS3.1
#=GS F6UWD8_HORSE/37-104   AC F6UWD8.1
#=GS H9J3U1_BOMMO/8-75     AC H9J3U1.1
#=GS G5E246_9PIPI/38-94    AC G5E246.1
#=GS G3IBL5_CRIGR/32-99    AC G3IBL5.1
#=GS A3KG41_MOUSE/44-111   AC A3KG41.1
#=GS Q4G3H3_DANRE/43-110   AC Q4G3H3.1
#=GS G1K341_CHICK/37-104   AC G1K341.1
#=GS G3RQC2_GORGO/1-49     AC G3RQC2.1
#=GS A3KG37_MOUSE/50-117   AC A3KG37.1
#=GS G1MZZ3_MELGA/37-104   AC G1MZZ3.1
#=GS G1P540_MYOLU/37-104   AC G1P540.1
#=GS G3RVA2_GORGO/112-179  AC G3RVA2.1
#=GS A3KG40_MOUSE/44-111   AC A3KG40.1
#=GS F1LM08_RAT/1-49       AC F1LM08.1
#=GS F7GMH9_MACMU/44-111   AC F7GMH9.1
#=GS B5X3H2_SALSA/29-96    AC B5X3H2.1
#=GS F1RDV0_DANRE/26-93    AC F1RDV0.1
#=GS G3QQD5_GORGO/112-179  AC G3QQD5.1
#=GS G8JLS4_RAT/37-104     AC G8JLS4.1
#=GS A1L2U3_XENLA/31-98    AC A1L2U3.1
#=GS B7ZA56_HUMAN/1-47     AC B7ZA56.1
#=GS G1SRQ8_RABIT/38-105   AC G1SRQ8.1
#=GS D6W9Q5_TRICA/104-171  AC D6W9Q5.1
#=GS F1M9C4_RAT/37-104     AC F1M9C4.1
#=GS B0KWU0_CALJA/44-111   AC B0KWU0.1
#=GS B2KIK6_RHIFE/44-111   AC B2KIK6.1
#=GS G1K9C2_ANOCA/37-104   AC G1K9C2.1
#=GS E2A3H8_CAMFO/95-172   AC E2A3H8.1
#=GS H2N9S6_PONAB/37-104   AC H2N9S6.1
#=GS Q58EN3_DANRE/43-110   AC Q58EN3.1
#=GS Q0ZDL5_SALSA/29-96    AC Q0ZDL5.1
#=GS G3Q620_GASAC/36-103   AC G3Q620.1
#=GS G6DE28_DANPL/84-151   AC G6DE28.1
#=GS F6UWH6_HORSE/37-104   AC F6UWH6.1
#=GS Q001C7_GASAC/1-27     AC Q001C7.1
#=GS C3YPU4_BRAFL/78-145   AC C3YPU4.1
#=GS OPTN_MACMU/37-104     AC Q861Q8.1
#=GS F7BJ31_CIOIN/30-97    AC F7BJ31.1
#=GS OPTN_XENLA/31-98      AC Q5M7B7.1
#=GS H3A533_LATCH/18-85    AC H3A533.1
#=GS F7ADE2_MONDO/44-111   AC F7ADE2.1
#=GS H3A892_LATCH/35-99    AC H3A892.1
#=GS H2L9T8_ORYLA/1-49     AC H2L9T8.1
#=GS NEMO_MOUSE/44-111     AC O88522.2
#=GS F1QHG7_DANRE/43-110   AC F1QHG7.1
#=GS H9KJ83_APIME/116-190  AC H9KJ83.1
#=GS E9GHY3_DAPPU/22-95    AC E9GHY3.1
#=GS F6UET8_ORNAN/37-104   AC F6UET8.1
#=GS F7GML8_MACMU/44-111   AC F7GML8.1
#=GS OPTN_PONAB/37-104     AC Q5R923.1
#=GS D2I3B5_AILME/48-115   AC D2I3B5.1
#=GS F7GMH3_MACMU/44-111   AC F7GMH3.1
#=GS G7PED9_MACFA/37-104   AC G7PED9.1
#=GS Q4SSU6_TETNG/55-122   AC Q4SSU6.1
#=GS H2R099_PANTR/37-104   AC H2R099.1
#=GS A5WUQ0_DANRE/19-86    AC A5WUQ0.1
#=GS G3PIJ0_GASAC/28-95    AC G3PIJ0.1
#=GS F6UER0_ORNAN/37-104   AC F6UER0.1
#=GS G1RNU9_NOMLE/37-104   AC G1RNU9.1
#=GS C9J2V2_HUMAN/32-99    AC C9J2V2.1
#=GS E2B714_HARSA/95-162   AC E2B714.1
#=GS H2RI27_PANTR/112-179  AC H2RI27.1
#=GS H3CN64_TETNG/1-67     AC H3CN64.1
#=GS H2RZL3_TAKRU/15-82    AC H2RZL3.1
#=GS OPTN_DANRE/19-86      AC Q5RI56.2
#=GS F1Q438_CANFA/49-116   AC F1Q438.1
#=GS B4E184_HUMAN/1-47     AC B4E184.1
#=GS G5BE21_HETGA/37-104   AC G5BE21.1
#=GS H3A890_LATCH/36-103   AC H3A890.1
#=GS G1RVV7_NOMLE/44-111   AC G1RVV7.1
#=GS H2PXA1_PONAB/44-111   AC H2PXA1.1
#=GS E7EU78_HUMAN/44-111   AC E7EU78.1
#=GS OPTN_PIG/37-104       AC Q7YS99.1
#=GS NEMO_HUMAN/44-111     AC Q9Y6K9.2
#=GS NEMO_HUMAN/44-111     DR PDB; 3BRT B; 49-109;
#=GS NEMO_HUMAN/44-111     DR PDB; 3BRV D; 49-110;
#=GS NEMO_HUMAN/44-111     DR PDB; 3BRT D; 49-110;
#=GS NEMO_HUMAN/44-111     DR PDB; 3BRV B; 49-109;
#=GS G1STZ8_RABIT/45-112   AC G1STZ8.1
#=GS G3UCW2_LOXAF/37-104   AC G3UCW2.1
#=GS F7AMM1_CALJA/54-121   AC F7AMM1.1
#=GS H9FNG7_MACMU/37-104   AC H9FNG7.1
#=GS F7BRD6_MONDO/37-104   AC F7BRD6.1
#=GS G3TTB2_LOXAF/49-116   AC G3TTB2.1
#=GS H2N9S7_PONAB/37-104   AC H2N9S7.1
#=GS A9CB72_PAPAN/44-111   AC A9CB72.1
#=GS F6R1Z3_MONDO/37-104   AC F6R1Z3.1
#=GS NEMO_RAT/44-111       AC Q6TMG5.1
#=GS Q58EP1_DANRE/43-110   AC Q58EP1.1
#=GS OPTN_HUMAN/37-104     AC Q96CV9.2
#=GS F6WK94_MACMU/37-104   AC F6WK94.1
#=GS A3KG38_MOUSE/56-123   AC A3KG38.1
#=GS OPTN_CHICK/37-104     AC Q90Z16.1
#=GS F6TK31_HORSE/50-117   AC F6TK31.1
#=GS G3RFJ6_GORGO/37-104   AC G3RFJ6.1
#=GS F7DVK0_XENTR/33-100   AC F7DVK0.1
#=GS G3TB30_LOXAF/37-104   AC G3TB30.1
#=GS F6T3V5_CALJA/44-111   AC F6T3V5.1
#=GS F6Z6G3_XENTR/31-98    AC F6Z6G3.1
#=GS H2ZF39_CIOSA/39-83    AC H2ZF39.1
#=GS NEMO_BOVIN/44-111     AC Q95KU9.1
#=GS A9QT41_PIG/44-111     AC A9QT41.1
#=GS G7N1L3_MACMU/37-104   AC G7N1L3.1
#=GS F7I7M0_CALJA/37-104   AC F7I7M0.1
#=GS F4WV63_ACREC/88-155   AC F4WV63.1
#=GS F8W9A9_HUMAN/44-111   AC F8W9A9.1
#=GS F6UEP3_ORNAN/37-104   AC F6UEP3.1
#=GS G3Q622_GASAC/15-82    AC G3Q622.1
#=GS H0WAZ4_CAVPO/45-112   AC H0WAZ4.1
#=GS D2HSV8_AILME/37-104   AC D2HSV8.1
#=GS H0XPP3_OTOGA/45-112   AC H0XPP3.1
#=GS B7NZR1_RABIT/44-111   AC B7NZR1.1
#=GS G1M4E5_AILME/37-104   AC G1M4E5.1
#=GS H0YVJ9_TAEGU/11-78    AC H0YVJ9.1
#=GS H3A891_LATCH/36-103   AC H3A891.1
#=GS G3GVQ4_CRIGR/87-154   AC G3GVQ4.1
#=GS H0WGU6_OTOGA/37-104   AC H0WGU6.1
#=GS H2RZL4_TAKRU/28-95    AC H2RZL4.1
#=GS G3VKD7_SARHA/44-111   AC G3VKD7.1
#=GS G1QA20_MYOLU/43-110   AC G1QA20.1
#=GS H2TNH3_TAKRU/32-99    AC H2TNH3.1
#=GS G9KEN4_MUSPF/37-104   AC G9KEN4.1
#=GS B1H373_XENTR/31-98    AC B1H373.1
#=GS C9JN51_HUMAN/44-111   AC C9JN51.1
#=GS A8MV29_HUMAN/44-111   AC A8MV29.2
#=GS C9JCG6_HUMAN/44-111   AC C9JCG6.1
#=GS B0WII8_CULQU/115-181  AC B0WII8.1
#=GS E9Q2Y3_MOUSE/56-123   AC E9Q2Y3.1
#=GS A3KG39_MOUSE/44-111   AC A3KG39.1
#=GS H2RZL1_TAKRU/28-95    AC H2RZL1.1
#=GS B0K002_XENTR/33-100   AC B0K002.1
#=GS OPTN_MOUSE/37-104     AC Q8K3K8.1
#=GS F1RZ22_PIG/48-115     AC F1RZ22.1
#=GS F7GWR3_MACMU/44-111   AC F7GWR3.1
#=GS B0LXP7_PIG/44-111     AC B0LXP7.1
#=GS H3A532_LATCH/43-113   AC H3A532.1
#=GS OPTN_RAT/37-104       AC Q8R5M4.3
#=GS B1MTU0_CALMO/44-111   AC B1MTU0.1
#=GS G1KMI1_ANOCA/19-86    AC G1KMI1.1
#=GS C9J1R1_HUMAN/44-111   AC C9J1R1.1
#=GS B3RFE3_SORAR/44-110   AC B3RFE3.1
#=GS G5BFL6_HETGA/1-51     AC G5BFL6.1
#=GS H9IJB0_ATTCE/88-155   AC H9IJB0.1
#=GS F7DZC7_ORNAN/44-111   AC F7DZC7.1
#=GS H2RZL2_TAKRU/28-95    AC H2RZL2.1
#=GS E2RBP8_CANFA/37-104   AC E2RBP8.1
#=GS OPTN_MACFA/37-104     AC Q95KA2.2
#=GS H0VAE0_CAVPO/37-104   AC H0VAE0.1
#=GS Q3UG24_MOUSE/56-123   AC Q3UG24.1
#=GS F7GMH1_MACMU/112-179  AC F7GMH1.1
#=GS C9JH59_HUMAN/44-111   AC C9JH59.1
#=GS E0VHH6_PEDHC/71-147   AC E0VHH6.1
#=GS F7ASB3_CALJA/49-116   AC F7ASB3.1
#=GS H2TNH4_TAKRU/1-66     AC H2TNH4.1
#=GS A3KG33_MOUSE/62-129   AC A3KG33.1
#=GS Q58EW6_XENLA/33-100   AC Q58EW6.1
#=GS F1QHM5_DANRE/43-110   AC F1QHM5.1
G5E140_9PIPI/16-75               .....DAEMLEQIKQLLHENNNLK...ETMKQMNQGMKERLEELLKRHNQRLVDLNSENELLRKEL----------hs..................
Q3ZC32_BOVIN/37-104              ....p-HELLQQMRELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLYFETQSKEAKERLTALSLEN....................
Q8VC91_MOUSE/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
Q2MH90_RAT/30-97                 ....p-EELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHEN....................
H2N2R3_ORYLA/37-104              ....l-EETLQQMNILIQENRDLK...EALRQTNLTMKERFEGLSAWREKQKQERDFLENQLKEAQRNMESVV---gqn.................
G6D3R2_DANPL/14-81               ....t-EELQKRFGDLLDENFVLK...ETLKQNNDSMKEQFILIASCQEDMLKTHRLHKEKFDETRELVERLRQEN....................
Q7TSS3_MOUSE/62-129              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
F6UWD8_HORSE/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLFFEIQSKEAKERLMALSHEN....................
H9J3U1_BOMMO/8-75                ....t-EELQKRFGELLDENLILK...ETLKQNNDSMKEQFLLIASCQEDMMKTHMLHKEKFEETKELVERLRQEN....................
G5E246_9PIPI/38-94               ....e-LATHEVFQRILAENQDLR...TALEQSNLMLRKGHSEILEFQETQKREREFIAIKFGEA-----------....................
G3IBL5_CRIGR/32-99               ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
A3KG41_MOUSE/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
Q4G3H3_DANRE/43-110              ....d-LAGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQEN....................
G1K341_CHICK/37-104              ....p-EEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKEEREFYETKFKEAKQCLLAKCVEN....................
G3RQC2_GORGO/1-49                .....-------------------...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCRFQEARKLVERLSLEK....................
A3KG37_MOUSE/50-117              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
G1MZZ3_MELGA/37-104              ....p-EEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKEEREFYEAKFKEAKQCLLAKCIEN....................
G1P540_MYOLU/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFQELSAWTEKQKEERHFFEIQSKEAKERLMAVSHEN....................
G3RVA2_GORGO/112-179             ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCRFQEARKLVERLSLEK....................
A3KG40_MOUSE/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
F1LM08_RAT/1-49                  .....-------------------...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
F7GMH9_MACMU/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
B5X3H2_SALSA/29-96               ....l-EETLQQMNRLIQENRDLK...EALKQTNMSMKERFEGLSVWREKQREEKEFLEGRLDEARGRMEALSSHN....................
F1RDV0_DANRE/26-93               ....l-EETLQQMNTLIKENRDLK...EALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVEN....................
G3QQD5_GORGO/112-179             ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCRFQEARKLVERLSLEK....................
G8JLS4_RAT/37-104                ....p-EELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHEN....................
A1L2U3_XENLA/31-98               .....DAEMLEQIKQLLMENNNLK...ETMKQMNQEMKERLEVLLKRHNQHLLDLKSENEVLRKELQCLKERN---aty.................
B7ZA56_HUMAN/1-47                .....-------------------...--MKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
G1SRQ8_RABIT/38-105              ....t-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWSEKQKEERQFFELQSKESKERIMALSHEN....................
D6W9Q5_TRICA/104-171             ....y-EEIQKQVEELIKENEKLK...NIIAQNNMSMKAQYTRFLAYRDEVTNVMKSYKDKFNDAKMCIDKYKEEN....................
F1M9C4_RAT/37-104                ....p-EELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHEN....................
B0KWU0_CALJA/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
B2KIK6_RHIFE/44-111              ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRECCEELQRFQGNQREEKEFLMQRFQEARSLVERLSLEK....................
G1K9C2_ANOCA/37-104              ....v-EEMVQQMKELITENNELK...EAVRQHNQAMKDRFENLSEWSEKLKEEREFYEIKFKEARQCLASKCVEN....................
E2A3H8_CAMFO/95-172              ...td--EMQKKLSDMLQENVKLK...ETLKQNTLSMKEQFSTLAMWQEEVMKVHENHKKKFAETRELINHLKKENaelktklshl..........
H2N9S6_PONAB/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
Q58EN3_DANRE/43-110              ....d-LAGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQEN....................
Q0ZDL5_SALSA/29-96               ....l-EETLQQMNHLIQENRDLK...EALKQTNMSMKERFEGLSVWREKQREEKEFLEGRLDEACGLVEALSSHN....................
G3Q620_GASAC/36-103              ....l-EETLQQMNILIQENRDLK...EALRQTNLMMKDRFEGLSAWREKQREERDFLENKLEDARGRMEALTLQN....................
G6DE28_DANPL/84-151              ....t-EELQKRFGDLLDENFVLK...ETLKQNNDSMKEQFILIASCQEDMLKTHRLHKEKFDETRELVERLRQEN....................
F6UWH6_HORSE/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLFFEIQSKEAKERLMALSHEN....................
Q001C7_GASAC/1-27                ....r-------------------...-----------------------TRDEREFLSCRFQEARALVERLAQEN....................
C3YPU4_BRAFL/78-145              ...ag--EMQSYMTELLKDNNSLR...DTIRQNNEDMRQKIKDLEVWKEKQKQNQALIVGKFTEAREKVLSLRKEN....................
OPTN_MACMU/37-104                ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
F7BJ31_CIOIN/30-97               .nsml----SQLLDNLITGNQDLK...QTIKVNNEELYSKCESLLKWKKDVDDKVKKLFDTCDRARVKVQSMKEQ-n...................
OPTN_XENLA/31-98                 .....DAEMLEQIKQLLMENNNLK...ETMKQMNQEMKERLEELLKRHNQHLLDLNSANEVLRKELQSLKEKIAT-s...................
H3A533_LATCH/18-85               ..eln---SQEALQRLQAENYDLR...EAMRQSNLALRERYDELLAFRARNKEEKDFMLERFKEARCLVEKLSQEK....................
F7ADE2_MONDO/44-111              ..sqv---SPEALQRFLEENQELR...DALRQSNQMLRERYQEFVNFQANQKEEKEFLMRKFQEARTLVEKLKTEK....................
H3A892_LATCH/35-99               ....p-EETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRAKEKL-----------------------laltkeneelkktvqiqeek
H2L9T8_ORYLA/1-49                .....-------------------...EALRRSNQALRLRCEEMEGWQQRTRDEREFLSCRFQEARALVERLAQEN....................
NEMO_MOUSE/44-111                ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
F1QHG7_DANRE/43-110              ....d-LAGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQEN....................
H9KJ83_APIME/116-190             ....t-AEVHQKLNELLQENTKLK...ETLKQNNIAMKQQFNVLATWQEEIMRVHQNHKKKFAETRELINYLKKENtelkmkl.............
E9GHY3_DAPPU/22-95               ....v-EEIEEKIQTLITENTGLR...NTLQQNNTYMRQLSSTLVEWQEEVIRVQSVYQNKVERAKEVITKLKEENaalkek..............
F6UET8_ORNAN/37-104              ....p-EEMLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWREKQKEERQFFESKFKEAKERLLALSNEK....................
F7GML8_MACMU/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
OPTN_PONAB/37-104                ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
D2I3B5_AILME/48-115              ....e-QGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRKEKEFLMQKFQEARKLVERLSLEK....................
F7GMH3_MACMU/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
G7PED9_MACFA/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
Q4SSU6_TETNG/55-122              ....f-FLVLFAFIPFLNSRLLCA...ESLRQTNLMMKDRFEDLAVWREKQRGERDILERQLEEARVHMEALTHQN....................
H2R099_PANTR/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
A5WUQ0_DANRE/19-86               ....l-EETLQQMNTLIKENRDLK...EALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVEN....................
G3PIJ0_GASAC/28-95               ...el--ASNEVVTRLLGDNQQLR...EALRRSNVALRQRCEEMEGWQQRTRDEREFLSCRFQEARALVERLAQEN....................
F6UER0_ORNAN/37-104              ....p-EEMLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWREKQKEERQFFESKFKEAKERLLALSNEK....................
G1RNU9_NOMLE/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
C9J2V2_HUMAN/32-99               ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
E2B714_HARSA/95-162              ...in--ETHKKLTELLQENTKLK...ETLKQNSLAMKKQLSTMASWQGIVMKLHENHKKKFKETTDLINNLKREN....................
H2RI27_PANTR/112-179             ....e-QGAPETLQRCLEENQELR...DAIRQSNQCCGKRCEEVLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
H3CN64_TETNG/1-67                .....-EETLHQMNILIQENRDLK...ESLRQTNLMMKDRFEDLAVWREKQRGERDILERQLEEARVHMEALTHQN....................
H2RZL3_TAKRU/15-82               ....e-LAANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSREDREFLSCRFQEARALVERLAEKN....................
OPTN_DANRE/19-86                 ....l-EETLQQMNTLIKENRDLK...EALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVEN....................
F1Q438_CANFA/49-116              ....e-QGTPETYQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQRKEKEFLMQKFQEARKLVERLSLEK....................
B4E184_HUMAN/1-47                .....-------------------...--MKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
G5BE21_HETGA/37-104              ....p-EELLQQMKELLAENHQLK...EAMKLNNQAMKGRFEELSAWTERQKEERQFFEMQSKEAKERLMALSHEN....................
H3A890_LATCH/36-103              ....p-EETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRGRQKEEREFLERKFQEAKEKLLALTKEN....................
G1RVV7_NOMLE/44-111              ....e-HGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
H2PXA1_PONAB/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
E7EU78_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
OPTN_PIG/37-104                  ....p-HELLQQMRELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLFFETQSKEAKERLTALSLEN....................
NEMO_HUMAN/44-111                ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
#=GR NEMO_HUMAN/44-111     SS    ....X-XXXX-HHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCX-X...................
G1STZ8_RABIT/45-112              ...eq--GAPDALQRCLEENQELR...DAIRQSNQMLRERCEELLRFQVSQREEKEFLLCKFQEARKLVERLNLEK....................
G3UCW2_LOXAF/37-104              ....p-EELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLIALSHEN....................
F7AMM1_CALJA/54-121              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
H9FNG7_MACMU/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
F7BRD6_MONDO/37-104              ....p-EEMLKQMKELLIENHQLK...EAMKLNNQTMKGRFEELSAWTEKQKEERQCFELKFKEVKENLLSLSNEN....................
G3TTB2_LOXAF/49-116              ..eqg---ASEPLQRCLEENQELR...DAFRESNQMLRERCEELLHFQVSQREEKEFLMQKFQEARKLVEKLSLEK....................
H2N9S7_PONAB/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
A9CB72_PAPAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
F6R1Z3_MONDO/37-104              ....p-EEMLKQMKELLIENHQLK...EAMKLNNQTMKGRFEELSAWTEKQKEERQCFELKFKEVKENLLSLSNEN....................
NEMO_RAT/44-111                  ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
Q58EP1_DANRE/43-110              ....d-LAGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQEN....................
OPTN_HUMAN/37-104                ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
F6WK94_MACMU/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
A3KG38_MOUSE/56-123              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
OPTN_CHICK/37-104                ....p-EEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSIWREKQKEEREFYETKFKEAKQCLLAKCVEN....................
F6TK31_HORSE/50-117              ....e-QGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQHFQSSQREEKEFLMQKFQEARKLVERLSLEK....................
G3RFJ6_GORGO/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
F7DVK0_XENTR/33-100              ....e-LTSNEAFQRIWAENHDLR...AALEQSNMMLRKGHGDMLEFQDSQRKEREFITYKFGEARDLVLRLTNER....................
G3TB30_LOXAF/37-104              ....p-EELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLIALSHEN....................
F6T3V5_CALJA/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
F6Z6G3_XENTR/31-98               .....DAEMLEQIKQLLMENNNLK...ETMKQMNQEMKERLEELLKRHNQHLLDLNSENELLRKELNSLREKNAT-s...................
H2ZF39_CIOSA/39-83               ..htm---LNQLLSKLITGNNDLK...QTIRVNNQQLHDKCNALVQWKA---------------------------nvdr................
NEMO_BOVIN/44-111                ....e-QGTPETFQRCLEENQELR...DAIRQSNQMLRERCEELQHFQGNQREEKAFLMQKFQEARDLVVRLSLEK....................
A9QT41_PIG/44-111                ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQREEKEFLMQKFCEARRLVERLSLEK....................
G7N1L3_MACMU/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
F7I7M0_CALJA/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSQEN....................
F4WV63_ACREC/88-155              ..vta---MQDRLVEVLQENVKLK...ETLRQTNVSMKQHFNTLTMWQEEVTKVHLSHKQQFAETKELINHLKKEN....................
F8W9A9_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
F6UEP3_ORNAN/37-104              ....p-EEMLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWREKQKEERQFFESKFKEAKERLLALSNEK....................
G3Q622_GASAC/15-82               ....l-EETLQQMNILIQENRDLK...EALRQTNLMMKDRFEGLSAWREKQREERDFLENKLEDARGRMEALTLQN....................
H0WAZ4_CAVPO/45-112              ....e-QGSPEALQHCLEENHELR...DAIRQNNQMLRERCEELLHFQASQKEEREFLMCKFQEARKLVERLSLEK....................
D2HSV8_AILME/37-104              ....p-EELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTERQKEERLFFETQSKEAKERLMALSHEN....................
H0XPP3_OTOGA/45-112              ....e-QGTPETLQRCVEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKAFLTHKFQEARKLVERLSLEK....................
B7NZR1_RABIT/44-111              ...eq--GAPDALQRCLEENQELR...DAIRQSNQMLRERCEELLRFQVSQREEKEFLLCKFQEARKLVERLNLEK....................
G1M4E5_AILME/37-104              ....p-EELLQQMKELLIENHQLK...EAMKLNNQAMKGRFEELSAWTERQKEERLFFETQSKEAKERLMALSHEN....................
H0YVJ9_TAEGU/11-78               ....p-EEMVQQMKELITENNELK...EAMKLHNQAMKDRYEELSTWREKQKEEREFYELKFKEAKQCLQAKCIEN....................
H3A891_LATCH/36-103              ....p-EETLQQIQELIKENGELK...EAVKQTNQAMKERYDELSAWRGRQKEEREFLERKFQEAKEKLLALTKEN....................
G3GVQ4_CRIGR/87-154              ....p-EEMLQQMKELLVENHQLK...EAMKLNNQAMKGRYEELSAWAEKQKEERQLFDTQNKEAKKLLMTLSYEN....................
H0WGU6_OTOGA/37-104              ....p-EELLRQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSREAKQRLMALSHEN....................
H2RZL4_TAKRU/28-95               ....e-LAANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSREDREFLSCRFQEARALVERLAE--ks..................
G3VKD7_SARHA/44-111              ..nqv---SPEALQRCLEENQELR...DALRQSNHMLRQRYQEFLNFQANQKEEKEFLMQKFQEARKLVEKLNMEK....................
G1QA20_MYOLU/43-110              ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRECCEELQRFQGSQREEKEFLMQKFQEARKLVERLNLEK....................
H2TNH3_TAKRU/32-99               ....l-EETLHQMNILIQENRDLK...ESLRQTNLAMKERFEGLAAWREKQREERDFLESRLKEARDRMEALTCQN....................
G9KEN4_MUSPF/37-104              ....p-EELLRQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLFFEIQSKEAKERLMALSHEN....................
B1H373_XENTR/31-98               .....DAEMLEQIKQLLMENNNLK...ETMKQMNQEMKERLEELLKRHNQHLLDLNSENELLRKELNSLREKNAT-s...................
C9JN51_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
A8MV29_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
C9JCG6_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
B0WII8_CULQU/115-181             ..ide----VQALQHLLNEHGQMK...DSLHKANVAMRKNFTNIQKWQDEVKTKYAEQVRTIDEQRAALDGLEAEN....................
E9Q2Y3_MOUSE/56-123              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
A3KG39_MOUSE/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
H2RZL1_TAKRU/28-95               ....e-LAANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSREDREFLSCRFQEARALVERLAEEN....................
B0K002_XENTR/33-100              ....e-LTSNEAFQRIWAENHDLR...AALEQSNMMLRKGHGDMLEFQDSQRKEREFITYKFGEARDLVLRLTNER....................
OPTN_MOUSE/37-104                ....p-EELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLLFEMQSKEVKERLKALTHEN....................
F1RZ22_PIG/48-115                ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQREEKEFLMQKFCEARRLVERLSLEK....................
F7GWR3_MACMU/44-111              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
B0LXP7_PIG/44-111                ....e-QGAPETFQRCLEENQELR...DAIRQSNQMLRERCEELQRFQGSQREEKEFLMQKFCEARRLVERLSLEK....................
H3A532_LATCH/43-113              ..eln---SQEALQRLQAENYDLRvipEAMRQSNLALRERYDELLAFRARNKEEKDFMLERFKEARCLVEKLSQEK....................
OPTN_RAT/37-104                  ....p-EELLQQMKELLVENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHEN....................
B1MTU0_CALMO/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
G1KMI1_ANOCA/19-86               ...el--AGHEAVQHVLAENRDLK...EAIQRSNHMLRERYREFLQFQASHKQEKEFLFCKFQEARLLVENLQLER....................
C9J1R1_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
B3RFE3_SORAR/44-110              ....e-HAGPDTFQRCLEENQELR...DAIRQSNQMLRERCEELQRVQGGQREEKDFLLHKFRAARALVERLR---ac..................
G5BFL6_HETGA/1-51                ...ml-------------------...DAIRQSNQMLRERCEELLHFQASQREEKEFIMCKFQEARKLVERLSLEK....................
H9IJB0_ATTCE/88-155              ..vta---MQHRLVEVLQENVKLK...ETLRQNNVSMKQQFNTLAMWQEEVTKVHLSHKQQFAETKELINHLKKEN....................
F7DZC7_ORNAN/44-111              .dqdp----QEALQRFLVENQELR...EAIRQSNQMLREWYKEFLNFQANHKEEKEFLRRKFQGARNLVERLNLEK....................
H2RZL2_TAKRU/28-95               ....e-LAANEVFTRLLSDNQQLR...ETLRRSNLALRQRCEEMEGWQRRSREDREFLSCRFQEARALVERLAEEN....................
E2RBP8_CANFA/37-104              ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERLYFEVQSKEAKERLMALSHEN....................
OPTN_MACFA/37-104                ....p-EELLQQMKELLTENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHEN....................
H0VAE0_CAVPO/37-104              ....p-EELLQQMKELLAENHQLK...EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHEN....................
Q3UG24_MOUSE/56-123              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
F7GMH1_MACMU/112-179             ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
C9JH59_HUMAN/44-111              ....e-QGAPETLQRCLEENQELR...DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE-k...................
E0VHH6_PEDHC/71-147              gdaqd------KLNHLLQENQKLK...ETLNQNNLAIKSQLNTFFMWQQEVLKTHETHKQKFLETKDLILKLRLENanlkkqienm..........
F7ASB3_CALJA/49-116              ....e-QGAPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQASQREEKEFLMCKFQEARKLVERLSLEK....................
H2TNH4_TAKRU/1-66                .....--ETLHQMNILIQENRDLK...ESLRQTNLAMKERFEGLAAWREKQREERDFLESRLKEARDRMEALTCQN....................
A3KG33_MOUSE/62-129              ....e-QGTPETLQRCLEENQELR...DAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEK....................
Q58EW6_XENLA/33-100              ....e-LTNNEAFQRIWAENHDLR...GALEQSNKMLRKGHSELLEFQESQRKEREFITYKFGEARNLVLRLTSER....................
F1QHM5_DANRE/43-110              ....d-LAGNEIVQKLITDNHQLR...EALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQEN....................
#=GC SS_cons                     ....X-XXXX-HHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCX-X...................
#=GC seq_cons                    ......pth.pphpchLpENppL+...-Al+QsNQhh+cRhEEL.taptpQ+EE+-Fh.p+FpEA+chlppLohEp....................
//
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