GenomeNet

Database: Pfam
Entry: NESP55
LinkDB: NESP55
Original site: NESP55 
#=GF ID   NESP55
#=GF AC   PF06390.8
#=GF DE   Neuroendocrine-specific golgi protein P55 (NESP55)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_16185 (release 9.0)
#=GF GA   22.60 22.60;
#=GF TC   22.60 22.70;
#=GF NC   22.30 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12438142
#=GF RT   Neuroendocrine secretory protein 55: a novel marker for the
#=GF RT   constitutive secretory pathway. 
#=GF RA   Fischer-Colbrie R, Eder S, Lovisetti-Scamihorn P, Becker A,
#=GF RA   Laslop A; 
#=GF RL   Ann N Y Acad Sci 2002;971:317-322.
#=GF DR   INTERPRO; IPR009434;
#=GF CC   This family consists of several mammalian
#=GF CC   neuroendocrine-specific golgi protein P55 (NESP55) sequences.
#=GF CC   NESP55 is a novel member of the chromogranin family and is a
#=GF CC   soluble, acidic, heat-stable secretory protein that is expressed
#=GF CC   exclusively in endocrine and nervous tissues, although less
#=GF CC   widely than chromogranins [1].
#=GF SQ   50
#=GS U6DG36_NEOVI/1-199     AC U6DG36.1
#=GS G3V916_RAT/1-256       AC G3V916.1
#=GS A5GFT7_PIG/1-250       AC A5GFT7.1
#=GS W5P401_SHEEP/1-230     AC W5P401.1
#=GS M3WND3_FELCA/1-247     AC M3WND3.1
#=GS E2RBZ7_CANFA/1-247     AC E2RBZ7.1
#=GS GNAS3_HUMAN/1-245      AC O95467.1
#=GS L9L887_TUPCH/348-552   AC L9L887.1
#=GS L9L887_TUPCH/1-246     AC L9L887.1
#=GS G3TLL4_LOXAF/1-247     AC G3TLL4.1
#=GS G3GWT8_CRIGR/116-159   AC G3GWT8.1
#=GS GNAS3_BOVIN/1-241      AC O18979.1
#=GS H2BTI3_9FLAO/16-125    AC H2BTI3.1
#=GS GNAS3_MOUSE/1-257      AC Q9Z0F1.2
#=GS C4Y0X1_CLAL4/626-796   AC C4Y0X1.1
#=GS C0N3G6_9GAMM/313-447   AC C0N3G6.1
#=GS L5M895_MYODS/1-242     AC L5M895.1
#=GS H0Y7Z6_HUMAN/1-113     AC H0Y7Z6.1
#=GS G1S9I9_NOMLE/1-244     AC G1S9I9.1
#=GS S7Q0E8_MYOBR/1-242     AC S7Q0E8.1
#=GS G1RC94_NOMLE/853-1006  AC G1RC94.2
#=GS A6QPC1_BOVIN/1-241     AC A6QPC1.1
#=GS G3GWT8_CRIGR/149-295   AC G3GWT8.1
#=GS H0XJJ1_OTOGA/1-260     AC H0XJJ1.1
#=GS L5KZZ0_PTEAL/785-947   AC L5KZZ0.1
#=GS L8I6D5_9CETA/53-125    AC L8I6D5.1
#=GS M0WCE4_HORVD/79-176    AC M0WCE4.1
#=GS I3CBA0_9FLAO/7-125     AC I3CBA0.1
#=GS G1TF12_RABIT/1-240     AC G1TF12.1
#=GS U6GMM8_9EIME/211-340   AC U6GMM8.1
#=GS K1WC94_MARBU/4-89      AC K1WC94.1
#=GS A6PW70_MOUSE/1-59      AC A6PW70.1
#=GS G1PXY8_MYOLU/1-242     AC G1PXY8.1
#=GS A6PW71_MOUSE/1-25      AC A6PW71.1
#=GS F6S3D5_HORSE/1-250     AC F6S3D5.1
#=GS K7D1R5_PANTR/1-245     AC K7D1R5.1
#=GS A2A2S1_HUMAN/1-166     AC A2A2S1.1
#=GS D8TJY0_VOLCA/9-171     AC D8TJY0.1
#=GS F7DQ13_CALJA/1-253     AC F7DQ13.1
#=GS G3GWT8_CRIGR/1-113     AC G3GWT8.1
#=GS W0Q0Q9_BURPE/3-117     AC W0Q0Q9.1
#=GS S9Y7I7_9CETA/146-387   AC S9Y7I7.1
#=GS I3C2L9_9FLAO/10-125    AC I3C2L9.1
#=GS GNAS3_RAT/1-256        AC Q792G6.1
#=GS H2BXS8_9FLAO/30-137    AC H2BXS8.1
#=GS D5BAA9_ZUNPS/8-126     AC D5BAA9.1
#=GS F8HXK8_LEUS2/18-140    AC F8HXK8.1
#=GS L8I6D5_9CETA/124-272   AC L8I6D5.1
#=GS R7VYK5_AEGTA/387-516   AC R7VYK5.1
#=GS D2H1X6_AILME/1-245     AC D2H1X6.1
U6DG36_NEOVI/1-199                ......................................................------------------------------------------------NARAQQRaaAQ...........QR...RSFLNAHHRS---.--AAQVFPEP--PESDHEH....E..EGDLE....LSLPEC.LEYE-EEFDYES........ETETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.HTTF......GQ..SLT...ERLNALRLR.S.PDASPSRAQPSTQEPQNPRQGEEPEPKP..EDKDPRAPEESE.EPK--...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
G3V916_RAT/1-256                  ......................................................MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QR...RSFLNAHHRSAAA.AAAAQVLPESSESESDHEH....E..EAEPE....LARPEC.LEYDQDDYETET........DSETEPESDIQSETE..FETEPETEPETA.P.TTEPETE..PEDERG....P...R.GATF......NQ..SLT...QRLHALKLQ.S.ADASPRRAQPTTQEPESASEGEEPQREP..LDEDPRDPEESE.ELR-E...ANRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
A5GFT7_PIG/1-250                  ......................................................MDRRSRAQQGRRARHTYSDLCPPIGRRAATALLWLSCSIALLRALATSSARAQQR.aAA...........QR...RSFLNAHHRS---.--AAPVFPQP--PESDQEQ....E..EADLE....LSLPEC.LEYE-EEFDYE-........-SETETESEIESETD..SETEPETAPTTE.P.ETEPETE..PEDERGp.vlP...K.RPSF......AQ..SLT...ERLNALRLQ.S.PDASPSRAQPSTQESESPREGEEPKPEP..EDKDPRGPEESE.EPKAE...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
W5P401_SHEEP/1-230                ......................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSP-----..--...........-S...RSFLNAHHRS---.--AAQVFPEP--PESDHED....T..DLEPS....L--PEC.PEYQEEEFDYE-........-SETESESEIESETE..F----ETESDTA.P.TTEPETE..PEDERGp.vvP...K.RPTF......HQ..SLT...ERLSALRLR.S.PDASPSRAPPSTQESESPRQREEPE---..-DKDPRDPEESE.EPKEE...EKEQQRRCKPK.KPT-.RRDPSPESPSKRGPL-----afp........................................................................
M3WND3_FELCA/1-247                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPEP--PESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYES........ESETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.HTTF......GQ..SLT...ERLHALRLR.S.PDASPSRAQPSTQEPQNPRQGEEPE--P..EDKDPRDPEESE.EPKEE...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
E2RBZ7_CANFA/1-247                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPEP--PESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYES........ETETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.HSSF......GQ..SLT...ERLHALRLR.S.PDASPSRAQPSTQEPQNPREGEEPEPKP..EDKDPRDPEESE.EPK--...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
GNAS3_HUMAN/1-245                 ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPESPESESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYET........ESET--ESEIESETD..F----ETEPETA.P.TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLT...QRLHALKLR.S.PDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
L9L887_TUPCH/348-552              .................................................lhvqt---------------------------------------------------ALQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPEPPESESDHEHehehE..EADLE....LSLPEC.LEYQ-ESFDYE-........-TETETESEIESETD..FETDP--EPETA.P.TTEPETE..PEEERGp.vaP...K.NPHS......GQ..SLA...QRLHALKLQ.S.PHTSPSRAQPGIHERRGPRQGEEPE--P..KDKDPRDPEESE.EPREE...--KQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
L9L887_TUPCH/1-246                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPEPPESESDHEHehehE..EADLE....LSLPEC.LEYQ-ESFDYE-........-TETETESEIESETD..FETDP--EPETA.P.TTEPETE..PEEERGp.vaP...K.NPHS......GQ..SLA...QRLHALKLQ.S.PHTSPSRAQPGIHERRGPRQGEEPE--P..KDKDPRDPEESE.EPREE...--KQQRRCKPK.KPT-.RRDPSPEAPH----------xxxxx......................................................................
G3TLL4_LOXAF/1-247                ......................................................MDRRSRAYQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQR..AAa........qqQR...RSFLNAHHRS---.--AAQVVPEP--PESDQEQ....D..EGELD....LSLIEC.LEYE-EEFDYE-........-SETETESEIEYETD..FETDFET--ETA.P.TTEPETE..PEDERSp.vvP...K.RPTF......GQ..SLT...ERLNALKLR.S.PDASPSRAQPSTQEPQSPTEGEVPV--P..EQKDPRDPED--.-PKEE...QKKQRRRCKPKsKKSS.RRDPSPEPPSKRGPIPIRRH...........................................................................
G3GWT8_CRIGR/116-159              ...............................................raelpra-------------------------------------------------------..--...........--...-------------.-------------------....-..----V....LARPEC.LDYDDIESETES........ESETESETETETETE..TE----------.-.-------..------....-...-.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------t..........................................................................
GNAS3_BOVIN/1-241                 ......................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSTRAQQR.aAA...........QR...RTFLNAHHRS---.--AAQVFPEP--PESDHED....T..DFEPS....L--PEC.PEYQEEEFDYE-........-SETESESEIESETE..F----ETESDTA.P.TTEPETE..PEDEPGp.vvP...K.RPTF......HQ..SLT...ERLSALRLR.S.PDASPSRAPPSTQESESPRQGEEPE---..-DKDPRDPEESE.EPKEE...EKQQQHRCKPK.KPT-.RRDPSPESPSKRGAIPIRRH...........................................................................
H2BTI3_9FLAO/16-125               ............................rfqefsrthfkshteamgtmldfffy-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.---NEIS..PKEKLG....P...T.GRTI......EA..SIK...KRINAVIAI.M.RDMEKTQTKPTVAMIESLFQTEAPAKKP..LILEKKFIEEKK.EVRFQ...EKQNP------.----.--------------------nne........................................................................
GNAS3_MOUSE/1-257                 ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QR...RSFLNAHHRSAAA.AAAAQVLPESSESESDHEH....E..EVEPE....LARPEC.LEYDQDDYETET........DSETEPESDIESETE..IETEPETEPETA.P.TTEPETE..PEDERG....P...R.GATF......NQ..SLT...QRLHALKLQ.S.ADASPRRAQPTTQEPESASEGEEPQRGP..LDQDPRDPEEEP.EERKE...ENRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
C4Y0X1_CLAL4/626-796              ..........tlpsssvraerekpqthassthfssaqakqtgvnapalqaskpt-------------------------------------------------------..--...........--...------------A.RGKLQSLDEF-FGDSDDES....E..SAADS....QLESESeEELDSGLVTSES........ESESESESESESESE..SDAESESESEGGgS.EAEPESD..PEDESGasgsD...D.KPTF......AS..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------htaadrqnklskhalssvdydsdgsgrst..............................................
C0N3G6_9GAMM/313-447              .............................ttvivddtpqqeskqvelaqrdela-------------------------------------------------------..--...........--...-------------.-------------------....-..DLLAE....I--PVA.IEHSETETETET........ETETETETETETETE..TETETETETETE.T.ETETETE..TEGDLP....P...QtKQAL......SQ..PNT...ANTAVISEQkA.ADN-------------------------..------------.-----...-----------.----.--------------------qaaksaeaevqdsdwilsqkpt.....................................................
L5M895_MYODS/1-242                ......................................................MDRRSRA-HWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNTRAQQR..AA...........AR...RSFLNAHHRS---.--AAQVIPEP--PNSDSDQ....E..EADQD....LSRPEC.PDYE-EEFDYE-........-SETESESDIESDID..F----DTETETA.P.TTEPETE..PEDERG....PaalR.QRAF......GQ..SLT...QRLQALRVR.S.PDASPTRSQPRSQQPRSPREGEEPQPGP..RDRDLRDPEESE.KPK--...EKQQRGGCKPR.KPT-.RRDPSPESPSRRGPIPIRR-f..........................................................................
H0Y7Z6_HUMAN/1-113                .....................................................x-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLT...QRLHALKLR.S.PDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
G1S9I9_NOMLE/1-244                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQR.aAA...........QR...RSFLNAHHRS---.--GAQVFPESPESESDYEH....E..EADLE....LSLPEC.LEYE-EEFDYQT........ESET--ESEIESETD..F----ETEPETA.P.TTEPETE..PEDERGp.vvP...K.HSTF......GQ..SLT...QRLHALKLR.S.PDASPNRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.KPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
S7Q0E8_MYOBR/1-242                ......................................................MDRRSRA-HWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNTRAQQR..AA...........AR...RSFLNAHHRS---.--AAQVIPEP--PNSDSDQ....E..EADQD....LSRPEC.PDYE-EEFDYE-........-SETESESDIESDID..F----DTETETA.P.TTEPETE..PEDERG....PaalR.QRAF......GQ..SLT...QRLQALRVR.S.PDASPTRSQPRSQQPRSSREGEEPQPGP..RDRDLRDPEESE.KPK--...EKQQRGGCKPR.KPT-.RRDPSPESPSRRGPIPIRR-f..........................................................................
G1RC94_NOMLE/853-1006             retysetdkndnsthkmsssflgsqknvspgftkiqqpveeeseldleleseqe-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.---AGLGLDLDL........DRELEPESELEPEIEpkAETETETEMEPQ.P.ETEPEME..PDPKSR....P...R.AHTF......PQ..Q--...---------.-.----------------------------..------------.-----...-----------.----.--------------------hywpmchpsmastqsqtqprtwsverrrhpmdsyspegn....................................
A6QPC1_BOVIN/1-241                ......................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSTRAQQR.aAA...........QR...RTFLNAHHRS---.--AAQVFPEP--PESDHED....T..DFEPS....L--PEC.PEYQEEEFDYE-........-SETESESEIESETE..F----ETESDTA.P.TTEPETE..PEDEPGp.vvP...K.RPTF......HQ..SLT...ERLSALRLR.S.PDASPSRAPPSTQESESPRQGEEPE---..-NKDPRDPEESE.EPKEE...EKQQQHRCKPK.KPT-.RRDPSPESPSKRGAIPIRRH...........................................................................
G3GWT8_CRIGR/149-295              .....................................................t-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.--------ETET........ETETETESDIESETE..T--ETETESDTA.P.ATEPETE..PEDERG....P...R.GATF......NQ..SLT...QRLHALKLQ.S.ADASPRRAQPTTQESESDSEGEEPQRGP..LDQDPRDPEESDsDERQE...EARQPRRCKTR.RLARrRRDQSPESPPRKGPIPIRRH...........................................................................
H0XJJ1_OTOGA/1-260                ......................................................MDRRSRAHQWRRARHNYHDLCPPIGRRTATALLWLSCSIALLRALAASNARAQQR..AAaqqqqqqqqqqQR...RSFLNAHHRS---.--GAQVYPDSPESESDRET....EevDFEPS....L--PEC.LEYE-DDFEYET........ESESESESEIESETD..F----ETETDTA.P.TTEPETE..PEDERGp.vvP...K.QSTF......PQ..SLT...ERLQALKLR.S.PDASPSRAGPSTQEPQNTTEGEEPEKTPepEYQDPRNPEESE.ESK--...EKKRQRRCKPK.KSP-.RRDPSPESPKKKGPIPIRRH...........................................................................
L5KZZ0_PTEAL/785-947              ..........................etdkdaesrhkisssildapknvssgft-------------------------------------------------------..--...........--...-------------.-----MIQEPITEEESELD....M..ELEPT....L---ES.EQEAMRGLDLDL........CSELEPESELEPESE..LEPETELEPETE.L.ELEPEPE..PEPEPK....P...K.SKSR......PR..DQTyswQQYWPLYQQ.SkPSSSLSQTQPRTQSVERRRQHM------..------------.-----...-----------.----.--------------------nsyspkgsdted...............................................................
L8I6D5_9CETA/53-125               ......................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSTRAQQR.aAA...........QR...RTFLNAHHRSAA-.-------------------....-..-----....------.------------........---------------..------------.-.-------..------....-...-.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------q..........................................................................
M0WCE4_HORVD/79-176               .......................................nlkvsleeiapppqp-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.----EPEQEQEL........ESESEPEEDLESEPE..P--ELESESESE.P.EEDLESE..PEQELE....P...E.-LTF......WE..KTW...QVLHILRCK.GlADLDPKRN--------------------..------------.-----...-----------.----.--------------------alvptrv....................................................................
I3CBA0_9FLAO/7-125                ....................irfkketakrfqqfsrthfkshteamatmldfff-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.--YNEIS..PREKLG....P...T.GRTI......EA..NLK...KRINAVIAI.M.RDMEKTQTKPTAAMIESLFQSEEPKKKP..LILEKKFVEEKP.KVKFQ...EKQNH------.----.--------------------nne........................................................................
G1TF12_RABIT/1-240                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSARAQQR.aAA...........QR...RSFLNAHHRT---.--AAQVFPESPESESDHEH....E..EAHVD....LSLPEC.LEFEGEEFDYES........ESETESESEIESETD..F----ETEPETA.P.ATEPETEpePEDERGp.avP...K.GSAF......NQ..SLT...QRLQALKLR.S.---------PSAQQPPNPREGEEPGRAA..E--SRSDPAEPQ.EPK--...EKKQQRRCRPK.KPT-.RRDQSPESPSRKGPIPIRRH...........................................................................
U6GMM8_9EIME/211-340              ........................................prcieantlwrsqf-------------------------------------------------------..-A...........QRlptKTFTTAVSAAAAA.ASAAAVGPNSSSTTTTNTR....I..QTATGtgrgFSSDGF.IETEEDQRETET........ETETETETETETETE..TETETETETEGE.T.ETETETE..TETETE....T...-.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------etdtlrdr...................................................................
K1WC94_MARBU/4-89                 .............................................lrsgstyda-------------------------------------------------------..--...........--...-------------.-------------------....-..SQKPR....LITPPE.AEPVQAEPETEP........EAEPEAEPETEPETE..LETEPEAEPETE.P.EAEPEAK..LEGEPK....A...K.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------vqdglffrkip................................................................
A6PW70_MOUSE/1-59                 ......................................................-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.-------..------....-...-.----......--..---...---------.-.---------------------EEPQRGP..LDQDPRDPEEEP.EERKE...ENRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
G1PXY8_MYOLU/1-242                ......................................................MDRRSRA-HWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNTRAQQR..AA...........AR...RSFLNAHHRS---.--AAQVIPEP--PNSDSDQ....E..EADQD....LSRPEC.PDYE-EEFDYE-........-SETESESDIESDID..F----DTETETA.P.TTEPETE..PEDERG....PaalR.QRAF......GQ..SLT...QRLQALRVR.S.PDASPTRSQPRSQQPRSSREGEEPRPGP..RDRDLRDPEESE.KPK--...EKQQGGGCKPR.KPT-.RRDPSPESPSRRGPIPIRR-f..........................................................................
A6PW71_MOUSE/1-25                 ......................................................-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.-------..------....-...-.----......--..---...---------.-.----------------------------..------------.-----...----------R.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
F6S3D5_HORSE/1-250                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQAFPEP--PESDQEH....E..EADLE....LSLPEC.LEYE-EEFDYE-........-SETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.RPTF......GErgSLT...QRLQALRLR.S.PDASPSRAQPSTQEPQSPREGEEPE--P..EDKDPRDPEESE.EPKEKekkEKQQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
K7D1R5_PANTR/1-245                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPESPESESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYET........ESET--ESEIESETD..F----ETEPETA.P.TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLT...QRLHALKLR.S.PDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRY...........................................................................
A2A2S1_HUMAN/1-166                .....................................................p-------------------------------------------------------..--...........--...-------------.-----------ESESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYET........ESET--ESEIESETD..F----ETEPETA.P.TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLT...QRLHALKLR.S.PDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
D8TJY0_VOLCA/9-171                ...............................................aygqliv-------------------------------------------------------..--...........--...-------------.AKDALVHPEEDEGK-LKDD....S..EDETD....LEDSET.ESGTESETESET........ESESESESESESETE..SETASESETETE.T.ATEAETT..ET-ER-....-...-.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------sttvtgtgdfksprpqqhlpaesmpslssppgdgvgkrsqasspkgspsrnpiaapryyqpppppppapmpkpre
F7DQ13_CALJA/1-253                ......................................................MDRRSRAQQWRRARQNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--GAQVFPESPESESDHEH....E..EADLE....LSLPEC.LEYE-EEFDYET........ESET--ESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.HSTFgqslaeSQ..SLT...QRLHALKLR.S.PDTSPSRAPPSTQEPQSPSEGEELK--P..EDKDPTDPEESE.EPK-E...EKQQRRRCKPK.KKPT.RREESPESPSKKGPIPIRRH...........................................................................
G3GWT8_CRIGR/1-113                ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QR...RSFLNAHPPSAAAaAAAAQVLPESPESESDQEL....E..GARAE....LPRAEL.P-----------........---------------..------------.-.-------..------....-...-.----......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------raelprae...................................................................
W0Q0Q9_BURPE/3-117                .....................................dhfrtkakakakakaka-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------EAKAEA........KAEAKAEAKAEAKAE..AEAEAEAETETE.T.ETETETE..TETETP....P..aR.RGAL......DR..SER...PATNAAR--.-.----------------------------..------------.-----...-----------.----.--------------------aryapsrrasscawrishasvcamspgrrgsl...........................................
S9Y7I7_9CETA/146-387              ......................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSARAQQR.aAA...........QR...RSFLNAHHRS---.--AAQVFPGP--PESDHEQ....E..EADLE....LSLPEC.LEYE-EEFDYE-........-SETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.RPTF......AQ..SLT...ERLNALRLR.S.PDASPSRAQPSTQQSQSPGEGEEPE--P..EDKDPRDPKESE.EPK--...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
I3C2L9_9FLAO/10-125               ...........................................krktakrfqef-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........-----------SKTH..FKTHTEAMENIL.DfFFYNEIS..PKEKLG....P...T.GRTI......EA..KLL...KRINAVIAI.M.RDVEKTQTKPTVAMIQSLFETEQPNKKP..LILEKKYAEEKK.EVRFR...EKQNP------.----.--------------------snq........................................................................
GNAS3_RAT/1-256                   ......................................................MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QR...RSFLNAHHRSAAA.AAAAQVLPESSESESDHEH....E..EAEPE....LARPEC.LEYDQDDYETET........DSETEPESDIQSETE..FETEPETEPETA.P.TTEPETE..PEDERG....P...R.GATF......NQ..SLT...QRLHALKLQ.S.ADASPRRAQPTTQEPESASEGEEPQREP..LDEDPRDPEESE.E-RRE...ANRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
H2BXS8_9FLAO/30-137               ..............................qefskthfkshteamatmldfffc-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.---NEIS..PREKLG....P...T.GRTI......EA..KLL...KRINAVIAI.M.RDMEKTQTKPTVAMMESLFQAEEPKRKP..LILEKKFTEERK.EVRFQ...EKRNT------.----.--------------------sne........................................................................
D5BAA9_ZUNPS/8-126                ......................rfknetakrfqefskthfkshtealetmldff-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....------.------------........---------------..------------.-.-FYNEIS..PKEKLG....P...T.GRTI......EA..KLL...KRINAVIAI.M.RDVEKTQTKPTVAMIQSLFEIEEPKKKP..LIVEKKYAEEQP.KVRFR...EKQNHH-----.----.--------------------neh........................................................................
F8HXK8_LEUS2/18-140               ..........................................apetvvtpvtde-------------------------------------------------------..--...........--...---------SESE.AVLSDVSSEITESTSDHSD....K..-IEEV....V--DKI.SEHDTQLTETET........ETETETETETETETE..TETETETETETE.T.ETETETE..TETEQQ....V...Y.DK--......--..---...---------.-.----------------------------..------------.-----...-----------.----.--------------------gleksrtgfaarfnrflanfrs.....................................................
L8I6D5_9CETA/124-272              .....................................................a-------------------------------------------------------..--...........--...-------------.-------------------....-..-----....----QC.PEYQEEEFDYE-........-SETESESEIESETE..F----ETESDTA.P.TTEPETE..PEDEPGp.vvP...K.RPTF......HQ..SLT...ERLSALRLR.S.PDASPSRAPPSTQESESPRQGEEPE---..-DKDPRDPEESE.EPKEE...EKQQQHRCKPK.KPT-.RRDPSPESPSKRGAIPIRRH...........................................................................
R7VYK5_AEGTA/387-516              ..........................................pydkmaydlsdd-------------------------------------------------------..--...........--...-------------.-----------ESETDLSD....T..DSDGE....Y-----.GTYPDGKTDANIddetytdqDAETETESGGESEIE..PDNEADGEPETE.P.DGELDME..PKDNAI....N...N.GVRD......ST..LIP...LSLWHMDVR.C.LDRSLRRIKIATTE--------------..------------.-----...-----------.----.--------------------dclskrc....................................................................
D2H1X6_AILME/1-245                ......................................................MDRRSRAQQWRRARHSYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QR...RSFLNAHHRS---.--AAQVFPEP--PESDHEH....E..EGDLE....LSLPEC.LEYE-EEFDYES........ETETETESEIESETD..F----ETEPETA.P.ATEPETE..PEDERGp.vvP...K.HTTF......GQ..SLT...ERLHALRLR.S.PDASPSRAQPSTQEPQNTRQGEEPE---..-DKDPRDPEESE.EPKEE...GKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
#=GC seq_cons                     ....................................................................................................................................................shsp...spoDppp....p..-hc.p....L..sEs..-ap.p-h-hE..........oETEsESElESET-..h....ETEsETt.P.sTEPETE..PE-EpG....P...+.t.oF......sQ..SLs...pRLpAL+lp.S.sDsS.sRs.Psspp.ps.tpuEE.p..s.....-.+sPEEpp.cs+.......pp.ttC+s+.+.s..RRD.SPEuP.++Gsl................................................................................
//
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