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Database: Pfam
Entry: NESP55
LinkDB: NESP55
Original site: NESP55 
#=GF ID   NESP55
#=GF AC   PF06390.7
#=GF DE   Neuroendocrine-specific golgi protein P55 (NESP55)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_16185 (release 9.0)
#=GF GA   22.60 22.60;
#=GF TC   22.80 22.70;
#=GF NC   22.30 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12438142
#=GF RT   Neuroendocrine secretory protein 55: a novel marker for the
#=GF RT   constitutive secretory pathway. 
#=GF RA   Fischer-Colbrie R, Eder S, Lovisetti-Scamihorn P, Becker A,
#=GF RA   Laslop A; 
#=GF RL   Ann N Y Acad Sci 2002;971:317-322.
#=GF DR   INTERPRO; IPR009434;
#=GF CC   This family consists of several mammalian
#=GF CC   neuroendocrine-specific golgi protein P55 (NESP55) sequences.
#=GF CC   NESP55 is a novel member of the chromogranin family and is a
#=GF CC   soluble, acidic, heat-stable secretory protein that is expressed
#=GF CC   exclusively in endocrine and nervous tissues, although less
#=GF CC   widely than chromogranins [1].
#=GF SQ   34
#=GS G3V916_RAT/1-256      AC G3V916.1
#=GS A5GFT7_PIG/1-250      AC A5GFT7.1
#=GS E2RBZ7_CANFA/1-247    AC E2RBZ7.1
#=GS GNAS3_HUMAN/1-245     AC O95467.1
#=GS G3TLL4_LOXAF/1-247    AC G3TLL4.1
#=GS G3GWT8_CRIGR/116-159  AC G3GWT8.1
#=GS GNAS3_BOVIN/1-241     AC O18979.1
#=GS H2BTI3_9FLAO/16-125   AC H2BTI3.1
#=GS C4Y0X1_CLAL4/626-796  AC C4Y0X1.1
#=GS GNAS3_MOUSE/1-257     AC Q9Z0F1.2
#=GS C0N3G6_9GAMM/313-447  AC C0N3G6.1
#=GS H0Y7Z6_HUMAN/1-113    AC H0Y7Z6.1
#=GS G1RC95_NOMLE/708-864  AC G1RC95.1
#=GS G1S9I9_NOMLE/1-244    AC G1S9I9.1
#=GS A6QPC1_BOVIN/1-241    AC A6QPC1.1
#=GS G3GWT8_CRIGR/149-295  AC G3GWT8.1
#=GS H0XJJ1_OTOGA/1-260    AC H0XJJ1.1
#=GS G1TF12_RABIT/1-240    AC G1TF12.1
#=GS A6PW70_MOUSE/1-59     AC A6PW70.1
#=GS F6S3D5_HORSE/1-250    AC F6S3D5.1
#=GS A6PW71_MOUSE/1-25     AC A6PW71.1
#=GS A6PW69_MOUSE/1-253    AC A6PW69.1
#=GS G1PXY8_MYOLU/1-242    AC G1PXY8.1
#=GS A2A2S1_HUMAN/1-166    AC A2A2S1.1
#=GS D8TJY0_VOLCA/9-171    AC D8TJY0.1
#=GS G3GWT8_CRIGR/1-113    AC G3GWT8.1
#=GS F7DQ13_CALJA/1-253    AC F7DQ13.1
#=GS G1RC94_NOMLE/816-969  AC G1RC94.1
#=GS A2A2S2_HUMAN/1-112    AC A2A2S2.1
#=GS GNAS3_RAT/1-256       AC Q792G6.1
#=GS H2BXS8_9FLAO/30-137   AC H2BXS8.1
#=GS D5BAA9_ZUNPS/8-126    AC D5BAA9.1
#=GS F8HXK8_LEUS2/18-140   AC F8HXK8.1
#=GS D2H1X6_AILME/1-245    AC D2H1X6.1
G3V916_RAT/1-256                 .........................................................MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QRRSFLNAHHRSAAA.AAAAQVLPESSESESDHEHE..EAEPELARPEC.LEYDQDDYETETDSETEPESDIQSETE..FETEPETEPETA.PTTEPETE..PEDERG....P...R.GATF......NQ..SLTQRLHALKLQ.SADASPRRAQPTTQEPESASEGEEPQREP..LDEDPRDPEESE.ELR-E...ANRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
A5GFT7_PIG/1-250                 .........................................................MDRRSRAQQGRRARHTYSDLCPPIGRRAATALLWLSCSIALLRALATSSARAQQR.aAA...........QRRSFLNAHHRS---.--AAPVFPQP--PESDQEQE..EADLELSLPEC.LEYE-EEFDYE--SETETESEIESETD..SETEPETAPTTE.PETEPETE..PEDERGp.vlP...K.RPSF......AQ..SLTERLNALRLQ.SPDASPSRAQPSTQESESPREGEEPKPEP..EDKDPRGPEESE.EPKAE...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
E2RBZ7_CANFA/1-247               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QRRSFLNAHHRS---.--GAQVFPEP--PESDHEHE..EADLELSLPEC.LEYE-EEFDYESETETETESEIESETD..F----ETEPETA.PATEPETE..PEDERGp.vvP...K.HSSF......GQ..SLTERLHALRLR.SPDASPSRAQPSTQEPQNPREGEEPEPKP..EDKDPRDPEESE.EPK--...EKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
GNAS3_HUMAN/1-245                .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QRRSFLNAHHRS---.--GAQVFPESPESESDHEHE..EADLELSLPEC.LEYE-EEFDYETESET--ESEIESETD..F----ETEPETA.PTTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLTQRLHALKLR.SPDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
G3TLL4_LOXAF/1-247               .........................................................MDRRSRAYQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQR..AAa........qqQRRSFLNAHHRS---.--AAQVVPEP--PESDQEQD..EGELDLSLIEC.LEYE-EEFDYE--SETETESEIEYETD..FETDFET--ETA.PTTEPETE..PEDERSp.vvP...K.RPTF......GQ..SLTERLNALKLR.SPDASPSRAQPSTQEPQSPTEGEVPV--P..EQKDPRDPED--.-PKEE...QKKQRRRCKPKsKKSS.RRDPSPEPPSKRGPIPIRRH...........................................................................
G3GWT8_CRIGR/116-159             ..................................................raelpra-------------------------------------------------------..--...........---------------.--------------------..----VLARPEC.LDYDDIESETESESETESETETETETE..TE----------.--------..------....-...-.----......--..------------.-----------------------------..------------.-----...-----------.----.--------------------t..........................................................................
GNAS3_BOVIN/1-241                .........................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSTRAQQR.aAA...........QRRTFLNAHHRS---.--AAQVFPEP--PESDHEDT..DFEPSL--PEC.PEYQEEEFDYE--SETESESEIESETE..F----ETESDTA.PTTEPETE..PEDEPGp.vvP...K.RPTF......HQ..SLTERLSALRLR.SPDASPSRAPPSTQESESPRQGEEPE---..-DKDPRDPEESE.EPKEE...EKQQQHRCKPK.KPT-.RRDPSPESPSKRGAIPIRRH...........................................................................
H2BTI3_9FLAO/16-125              ...............................rfqefsrthfkshteamgtmldfffy-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.----NEIS..PKEKLG....P...T.GRTI......EA..SIKKRINAVIAI.MRDMEKTQTKPTVAMIESLFQTEAPAKKP..LILEKKFIEEKK.EVRFQ...EKQNP------.----.--------------------nne........................................................................
C4Y0X1_CLAL4/626-796             .............tlpsssvraerekpqthassthfssaqakqtgvnapalqaskpt-------------------------------------------------------..--...........--------------A.RGKLQSLDEF-FGDSDDESE..SAADSQLESESeEELDSGLVTSESESESESESESESESE..SDAESESESEGGgSEAEPESD..PEDESGasgsD...D.KPTF......AS..------------.-----------------------------..------------.-----...-----------.----.--------------------htaadrqnklskhalssvdydsdgsgrst..............................................
GNAS3_MOUSE/1-257                .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QRRSFLNAHHRSAAA.AAAAQVLPESSESESDHEHE..EVEPELARPEC.LEYDQDDYETETDSETEPESDIESETE..IETEPETEPETA.PTTEPETE..PEDERG....P...R.GATF......NQ..SLTQRLHALKLQ.SADASPRRAQPTTQEPESASEGEEPQRGP..LDQDPRDPEEEP.EERKE...ENRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
C0N3G6_9GAMM/313-447             ................................ttvivddtpqqeskqvelaqrdela-------------------------------------------------------..--...........---------------.--------------------..DLLAEI--PVA.IEHSETETETETETETETETETETETE..TETETETETETE.TETETETE..TEGDLP....P...QtKQAL......SQ..PNTANTAVISEQkAADN-------------------------..------------.-----...-----------.----.--------------------qaaksaeaevqdsdwilsqkpt.....................................................
H0Y7Z6_HUMAN/1-113               ........................................................x-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.-TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLTQRLHALKLR.SPDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
G1RC95_NOMLE/708-864             tviretysetdkndnsthkmsssflgsqknvspgftkiqqpveeeseldleleseqe-------------------------------------------------------..--...........---------------.--------------------..-----------.---AGLGLDLDLDRELEPESELEPEIEpkAETETETEMEPQ.PETEPEME..PDPKSR....P...R.AHTF......PQ..Q-----------.-----------------------------..------------.-----...-----------.----.--------------------hywpmchpsmastqsqtqprtwsverrrhpmdsyspegn....................................
G1S9I9_NOMLE/1-244               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQR.aAA...........QRRSFLNAHHRS---.--GAQVFPESPESESDYEHE..EADLELSLPEC.LEYE-EEFDYQTESET--ESEIESETD..F----ETEPETA.PTTEPETE..PEDERGp.vvP...K.HSTF......GQ..SLTQRLHALKLR.SPDASPNRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.KPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
A6QPC1_BOVIN/1-241               .........................................................MDRRSRPQLGRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSTRAQQR.aAA...........QRRTFLNAHHRS---.--AAQVFPEP--PESDHEDT..DFEPSL--PEC.PEYQEEEFDYE--SETESESEIESETE..F----ETESDTA.PTTEPETE..PEDEPGp.vvP...K.RPTF......HQ..SLTERLSALRLR.SPDASPSRAPPSTQESESPRQGEEPE---..-NKDPRDPEESE.EPKEE...EKQQQHRCKPK.KPT-.RRDPSPESPSKRGAIPIRRH...........................................................................
G3GWT8_CRIGR/149-295             ........................................................t-------------------------------------------------------..--...........---------------.--------------------..-----------.--------ETETETETETESDIESETE..T--ETETESDTA.PATEPETE..PEDERG....P...R.GATF......NQ..SLTQRLHALKLQ.SADASPRRAQPTTQESESDSEGEEPQRGP..LDQDPRDPEESDsDERQE...EARQPRRCKTR.RLARrRRDQSPESPPRKGPIPIRRH...........................................................................
H0XJJ1_OTOGA/1-260               .........................................................MDRRSRAHQWRRARHNYHDLCPPIGRRTATALLWLSCSIALLRALAASNARAQQR..AAaqqqqqqqqqqQRRSFLNAHHRS---.--GAQVYPDSPESESDRETEevDFEPSL--PEC.LEYE-DDFEYETESESESESEIESETD..F----ETETDTA.PTTEPETE..PEDERGp.vvP...K.QSTF......PQ..SLTERLQALKLR.SPDASPSRAGPSTQEPQNTTEGEEPEKTPepEYQDPRNPEESE.ESK--...EKKRQRRCKPK.KSP-.RRDPSPESPKKKGPIPIRRH...........................................................................
G1TF12_RABIT/1-240               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSSARAQQR.aAA...........QRRSFLNAHHRT---.--AAQVFPESPESESDHEHE..EAHVDLSLPEC.LEFEGEEFDYESESETESESEIESETD..F----ETEPETA.PATEPETEpePEDERGp.avP...K.GSAF......NQ..SLTQRLQALKLR.S---------PSAQQPPNPREGEEPGRAA..E--SRSDPAEPQ.EPK--...EKKQQRRCRPK.KPT-.RRDQSPESPSRKGPIPIRRH...........................................................................
A6PW70_MOUSE/1-59                .........................................................-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.--------..------....-...-.----......--..------------.----------------------EEPQRGP..LDQDPRDPEEEP.EERKE...ENRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
F6S3D5_HORSE/1-250               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QRRSFLNAHHRS---.--GAQAFPEP--PESDQEHE..EADLELSLPEC.LEYE-EEFDYE--SETETESEIESETD..F----ETEPETA.PATEPETE..PEDERGp.vvP...K.RPTF......GErgSLTQRLQALRLR.SPDASPSRAQPSTQEPQSPREGEEPE--P..EDKDPRDPEESE.EPKEKekkEKQQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
A6PW71_MOUSE/1-25                .........................................................-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.--------..------....-...-.----......--..------------.-----------------------------..------------.-----...----------R.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
A6PW69_MOUSE/1-253               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QRRSFLNAHHRSAAA.AAAAQVLPESSESESDHEHE..EVEPELARPEC.LEYDQDDYETETDSETEPESDIESETE..IETEPET----E.PETEPETE..PEDERG....P...R.GATF......NQ..SLTQRLHALKLQ.SADASPRRAQPTTQEPESASEGEEPQRGP..LDQDPRDPEEEP.EERKE...ENRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
G1PXY8_MYOLU/1-242               .........................................................MDRRSRA-HWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNTRAQQR..AA...........ARRSFLNAHHRS---.--AAQVIPEP--PNSDSDQE..EADQDLSRPEC.PDYE-EEFDYE--SETESESDIESDID..F----DTETETA.PTTEPETE..PEDERG....PaalR.QRAF......GQ..SLTQRLQALRVR.SPDASPTRSQPRSQQPRSSREGEEPRPGP..RDRDLRDPEESE.KPK--...EKQQGGGCKPR.KPT-.RRDPSPESPSRRGPIPIRR-f..........................................................................
A2A2S1_HUMAN/1-166               ........................................................p-------------------------------------------------------..--...........---------------.-----------ESESDHEHE..EADLELSLPEC.LEYE-EEFDYETESET--ESEIESETD..F----ETEPETA.PTTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLTQRLHALKLR.SPDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
D8TJY0_VOLCA/9-171               ..................................................aygqliv-------------------------------------------------------..--...........---------------.AKDALVHPEEDEGK-LKDDS..EDETDLEDSET.ESGTESETESETESESESESESESETE..SETASESETETE.TATEAETT..ET-ER-....-...-.----......--..------------.-----------------------------..------------.-----...-----------.----.--------------------sttvtgtgdfksprpqqhlpaesmpslssppgdgvgkrsqasspkgspsrnpiaapryyqpppppppapmpkpre
G3GWT8_CRIGR/1-113               .........................................................MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QRRSFLNAHPPSAAAaAAAAQVLPESPESESDQELE..GARAELPRAEL.P--------------------------..------------.--------..------....-...-.----......--..------------.-----------------------------..------------.-----...-----------.----.--------------------raelprae...................................................................
F7DQ13_CALJA/1-253               .........................................................MDRRSRAQQWRRARQNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QRRSFLNAHHRS---.--GAQVFPESPESESDHEHE..EADLELSLPEC.LEYE-EEFDYETESET--ESEIESETD..F----ETEPETA.PATEPETE..PEDERGp.vvP...K.HSTFgqslaeSQ..SLTQRLHALKLR.SPDTSPSRAPPSTQEPQSPSEGEELK--P..EDKDPTDPEESE.EPK-E...EKQQRRRCKPK.KKPT.RREESPESPSKKGPIPIRRH...........................................................................
G1RC94_NOMLE/816-969             ...retysetdkndnsthkmsssflgsqknvspgftkiqqpveeeseldleleseqe-------------------------------------------------------..--...........---------------.--------------------..-----------.---AGLGLDLDLDRELEPESELEPEIEpkAETETETEMEPQ.PETEPEME..PDPKSR....P...R.AHTF......PQ..Q-----------.-----------------------------..------------.-----...-----------.----.--------------------hywpmchpsmastqsqtqprtwsverrrhpmdsyspegn....................................
A2A2S2_HUMAN/1-112               .........................................................-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.-TTEPETE..PEDDRGp.vvP...K.HSTF......GQ..SLTQRLHALKLR.SPDASPSRAPPSTQEPQSPREGEELK--P..EDKDPRDPEESK.EPKEE...--KQRRRCKPK.KPT-.RRDASPESPSKKGPIPIRRH...........................................................................
GNAS3_RAT/1-256                  .........................................................MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQR..AA...........QRRSFLNAHHRSAAA.AAAAQVLPESSESESDHEHE..EAEPELARPEC.LEYDQDDYETETDSETEPESDIQSETE..FETEPETEPETA.PTTEPETE..PEDERG....P...R.GATF......NQ..SLTQRLHALKLQ.SADASPRRAQPTTQEPESASEGEEPQREP..LDEDPRDPEESE.E-RRE...ANRQPRRCKTR.RPAR.RRDQSPESPPRKGPIPIRRH...........................................................................
H2BXS8_9FLAO/30-137              .................................qefskthfkshteamatmldfffc-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.----NEIS..PREKLG....P...T.GRTI......EA..KLLKRINAVIAI.MRDMEKTQTKPTVAMMESLFQAEEPKRKP..LILEKKFTEERK.EVRFQ...EKRNT------.----.--------------------sne........................................................................
D5BAA9_ZUNPS/8-126               .........................rfknetakrfqefskthfkshtealetmldff-------------------------------------------------------..--...........---------------.--------------------..-----------.---------------------------..------------.--FYNEIS..PKEKLG....P...T.GRTI......EA..KLLKRINAVIAI.MRDVEKTQTKPTVAMIQSLFEIEEPKKKP..LIVEKKYAEEQP.KVRFR...EKQNHH-----.----.--------------------neh........................................................................
F8HXK8_LEUS2/18-140              .............................................apetvvtpvtde-------------------------------------------------------..--...........-----------SESE.AVLSDVSSEITESTSDHSDK..-IEEVV--DKI.SEHDTQLTETETETETETETETETETE..TETETETETETE.TETETETE..TETEQQ....V...Y.DK--......--..------------.-----------------------------..------------.-----...-----------.----.--------------------gleksrtgfaarfnrflanfrs.....................................................
D2H1X6_AILME/1-245               .........................................................MDRRSRAQQWRRARHSYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRaaAQ...........QRRSFLNAHHRS---.--AAQVFPEP--PESDHEHE..EGDLELSLPEC.LEYE-EEFDYESETETETESEIESETD..F----ETEPETA.PATEPETE..PEDERGp.vvP...K.HTTF......GQ..SLTERLHALRLR.SPDASPSRAQPSTQEPQNTRQGEEPE---..-DKDPRDPEESE.EPKEE...GKKQQRRCKPK.KPT-.RRDPSPESPSKRGPIPIRRH...........................................................................
#=GC seq_cons                    ....................................................................................................................................................s.sp...spSDp-pp..phc.pL..sEs..-ap.p-h-hE..oETEsES-lEoET-..h....ETEs-Tt.PtTEPETE..PED-pG....P...+.tsTF......sQ..SLTpRLpAL+lp.SsDsp.pps.PosQpspssppGEE.p..P....pD.+sPEEp..-.+.p.....pQ.+RCKs+.+.s..RRD.SPESPs++GPIPIRRH...........................................................................
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