GenomeNet

Database: Pfam
Entry: NUMOD1
LinkDB: NUMOD1
Original site: NUMOD1 
#=GF ID   NUMOD1
#=GF AC   PF07453.10
#=GF DE   NUMOD1 domain
#=GF AU   Pietrokovski S
#=GF SE   Pietrokovski S
#=GF GA   22.80 13.50;
#=GF TC   22.80 13.60;
#=GF NC   22.70 13.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   13678957
#=GF RT   New types of conserved sequence domains in DNA-binding regions
#=GF RT   of homing endonucleases. 
#=GF RA   Sitbon E, Pietrokovski S; 
#=GF RL   Trends Biochem Sci 2003;28:473-477.
#=GF DR   INTERPRO; IPR010896;
#=GF CC   This domain probably represents a DNA-binding helix-turn-helix
#=GF CC   based on its similarity to other families (Bateman A pers obs).
#=GF SQ   98
#=GS A5J066_GIBZA/302-338      AC A5J066.1
#=GS Q9B6E2_YARLI/348-379      AC Q9B6E2.1
#=GS Q02656_PODAN/149-185      AC Q02656.1
#=GS MBI1_NEUCR/393-429        AC Q35127.2
#=GS Q02697_PODAN/414-457      AC Q02697.1
#=GS M2TTE0_COCH5/231-267      AC M2TTE0.1
#=GS A5H2U2_PICGU/174-210      AC A5H2U2.1
#=GS A7UG04_PHANO/189-222      AC A7UG04.1
#=GS H9CNM8_TALSN/270-306      AC H9CNM8.1
#=GS H9CNX0_ASPCL/243-279      AC H9CNX0.1
#=GS M5BUQ9_THACB/246-279      AC M5BUQ9.1
#=GS D5GGC2_TUBMM/245-281      AC D5GGC2.1
#=GS Q8DXH5_STRA5/125-161      AC Q8DXH5.1
#=GS Q8SDA6_BPDPK/196-232      AC Q8SDA6.1
#=GS F7WD56_SORMK/368-404      AC F7WD56.1
#=GS H6D5G5_GIBM7/254-289      AC H6D5G5.1
#=GS A5J043_GIBZA/247-278      AC A5J043.1
#=GS Q02681_PODAN/248-284      AC Q02681.1
#=GS D7GWF6_9FIRM/208-245      AC D7GWF6.1
#=GS A0A0A7H7S9_GIBZA/239-275  AC A0A0A7H7S9.1
#=GS R6QWW2_9CLOT/113-148      AC R6QWW2.1
#=GS H6D5G2_GIBM7/375-411      AC H6D5G2.1
#=GS Q8SDA6_BPDPK/275-312      AC Q8SDA6.1
#=GS M2TER9_COCH5/203-239      AC M2TER9.1
#=GS H9CNL3_TALSN/227-263      AC H9CNL3.1
#=GS YL245_MIMIV/111-146       AC Q5UPT6.1
#=GS M2UAP3_COCH5/184-219      AC M2UAP3.1
#=GS R5F2K5_9CLOT/88-119       AC R5F2K5.1
#=GS Q02656_PODAN/222-258      AC Q02656.1
#=GS Q9B6E2_YARLI/254-291      AC Q9B6E2.1
#=GS Q98474_PBCV1/290-327      AC Q98474.2
#=GS R5K3J2_9CLOT/5-34         AC R5K3J2.1
#=GS E7E828_OGAPD/468-505      AC E7E828.1
#=GS H9CNN1_TALSN/19-55        AC H9CNN1.1
#=GS H6D5D8_NECH7/282-318      AC H6D5D8.1
#=GS K5VGN3_AGABU/247-278      AC K5VGN3.1
#=GS K5WG41_AGABU/300-336      AC K5WG41.1
#=GS A7UG03_PHANO/202-238      AC A7UG03.1
#=GS Q02677_PODAN/251-291      AC Q02677.1
#=GS A5J071_GIBZA/78-111       AC A5J071.1
#=GS A5J066_GIBZA/386-422      AC A5J066.1
#=GS Q184B9_PEPD6/61-97        AC Q184B9.1
#=GS A0A0D1E0P9_USTMA/181-210  AC A0A0D1E0P9.1
#=GS A5J057_GIBZA/287-317      AC A5J057.1
#=GS R7BK61_9FIRM/129-164      AC R7BK61.1
#=GS H6D5G2_GIBM7/291-327      AC H6D5G2.1
#=GS K5WG41_AGABU/212-248      AC K5WG41.1
#=GS Q89820_PBCV1/191-227      AC Q89820.1
#=GS R7HLP8_9FIRM/131-167      AC R7HLP8.1
#=GS E4ZQ93_LEPMJ/321-357      AC E4ZQ93.1
#=GS A0A0B5ATB2_9BACL/104-139  AC A0A0B5ATB2.1
#=GS F7WD59_SORMK/32-63        AC F7WD59.1
#=GS YL245_MIMIV/278-314       AC Q5UPT6.1
#=GS Q02691_PODAN/288-324      AC Q02691.2
#=GS E7E828_OGAPD/717-753      AC E7E828.1
#=GS M7U6C3_BOTF1/40-74        AC M7U6C3.1
#=GS A7UG03_PHANO/129-165      AC A7UG03.1
#=GS Q02697_PODAN/179-219      AC Q02697.1
#=GS F2WVM0_MONRO/158-194      AC F2WVM0.1
#=GS C6XYU6_PEDHD/105-140      AC C6XYU6.1
#=GS Q24LE1_BPPCD/41-77        AC Q24LE1.1
#=GS M2UAN9_COCH5/179-218      AC M2UAN9.1
#=GS M2SI39_COCH5/141-177      AC M2SI39.1
#=GS MOBB_BPT4/213-249         AC P13329.1
#=GS Q02714_PODAN/559-598      AC Q02714.1
#=GS H9CNM8_TALSN/354-390      AC H9CNM8.1
#=GS Q8SDA6_BPDPK/130-166      AC Q8SDA6.1
#=GS D5GDY0_TUBMM/219-256      AC D5GDY0.1
#=GS Q02697_PODAN/260-299      AC Q02697.1
#=GS F7WD43_SORMK/269-305      AC F7WD43.1
#=GS Q02671_PODAN/177-213      AC Q02671.1
#=GS D5GGC2_TUBMM/192-228      AC D5GGC2.1
#=GS F7WD45_SORMK/199-236      AC F7WD45.1
#=GS IEND1_NEUCR/251-287       AC Q36580.1
#=GS C6Q1R8_9CLOT/484-517      AC C6Q1R8.1
#=GS H9CNU2_PENMQ/287-323      AC H9CNU2.1
#=GS A5J057_GIBZA/193-230      AC A5J057.1
#=GS R5T3B0_9CLOT/139-174      AC R5T3B0.1
#=GS R5IL14_9CLOT/84-118       AC R5IL14.1
#=GS O41133_PBCV1/173-210      AC O41133.1
#=GS H9CNU2_PENMQ/371-407      AC H9CNU2.1
#=GS TEV2_BPT4/159-196         AC P07072.2
#=GS F7WD39_SORMK/158-194      AC F7WD39.1
#=GS A5J040_GIBZA/215-249      AC A5J040.1
#=GS YMRF1_YEAST/418-454       AC P03881.3
#=GS H9CNS7_PENMQ/244-280      AC H9CNS7.1
#=GS R6KFR2_9CLOT/88-119       AC R6KFR2.1
#=GS Q84603_PBCV1/215-251      AC Q84603.2
#=GS BI1_USTMA/359-394         AC Q0H8X2.2
#=GS Q18AB6_PEPD6/61-97        AC Q18AB6.1
#=GS D7GWF6_9FIRM/139-173      AC D7GWF6.1
#=GS Q02691_PODAN/372-408      AC Q02691.2
#=GS H6D5D8_NECH7/366-402      AC H6D5D8.1
#=GS F7WD43_SORMK/353-389      AC F7WD43.1
#=GS Q02714_PODAN/481-520      AC Q02714.1
#=GS Q02697_PODAN/337-374      AC Q02697.1
#=GS A0A0B5ATB2_9BACL/336-372  AC A0A0B5ATB2.1
#=GS MOBB_BPT4/129-166         AC P13329.1
A5J066_GIBZA/302-338                 ...............YPVYIYDSFKNL....L.......VIFPSVSSLAHLIKSNHST.IVEAI........
Q9B6E2_YARLI/348-379                 ........fkgnpdn------------....N.......KVFTSLNELAKYLKGDRAT.IRKYL........
Q02656_PODAN/149-185                 ...............IEVEVTDLKTNT....T.......TTYHAIRAAARALDIDKRY.IEHYI........
MBI1_NEUCR/393-429                   ..............r-PVVLYNLNRTI....Y.......GKYSTILEAANAINCNEKT.IRRAL........
Q02697_PODAN/414-457                 ...............TSIWVYKYVDDKl.tlInd...nkPSYISKLSLSKDLKISVKT.INKYL........
M2TTE0_COCH5/231-267                 ..............r-PVVLYNLDRTI....Y.......GQYPTVLEAAKAINCNEKT.IRRAL........
A5H2U2_PICGU/174-210                 ..............l-KINIYDLDNNY....L.......CEFKNINTASHFLCCSNKT.IKR--sl......
A7UG04_PHANO/189-222                 ..............i----VTDLTLNI....K.......TSYHAIHSAARALNVDKRH.ISRAI........
H9CNM8_TALSN/270-306                 ...............YPIYIYNSYKKL....L.......VIFPSVLTFSKLINSNHST.IIN--vi......
H9CNX0_ASPCL/243-279                 ...............KSVILYNLNRTI....Y.......GKYASIVDAANAINCNEKT.IRRAL........
M5BUQ9_THACB/246-279                 ..............a--VEVLDLENNT....T.......TVYRSINEAARSINIYAS-.-----slsn....
D5GGC2_TUBMM/245-281                 ...............KAIFVYNTNKEF....I.......CKLDGVTHAEREFSISHEI.IKKYA........
Q8DXH5_STRA5/125-161                 ...............KPVEQFTLEGEF....I.......NTFDSIKSASMKTGISSQR.ITA--ta......
Q8SDA6_BPDPK/196-232                 ...............KTVYVLDYKTKT....L.......HVFHNLAEMELALGTKRNK.AYYHL........
F7WD56_SORMK/368-404                 ...............KTIEVTNIQTNE....V.......INYSSISSAGEALGIPQSS.ISVYL........
H6D5G5_GIBM7/254-289                 ..............g--VGIFDLNGNL....I.......EKFDNNVELAKYLEISKVT.VGKYL........
A5J043_GIBZA/247-278                 ..........dsegf----------KL....I.......GSFVSIRKAAKFLDISANT.VRLYI........
Q02681_PODAN/248-284                 ..............r-PVVLYNLNGTV....Y.......GEYSTILDAAKSINCDEKT.IRRAL........
D7GWF6_9FIRM/208-245                 .........ikvsqi------DIESGK...vL.......NTFKNVAEAGRRLGVNHKP.IYKV-i.......
A0A0A7H7S9_GIBZA/239-275             ...............KPIIVKELNNTV....Y.......GEFNSIVEAAEALNCSTKT.IQRTL........
R6QWW2_9CLOT/113-148                 .........tkvsvy-------LNNEF....I.......NTYSSIRELSKDLKIDRHK.VARIL........
H6D5G2_GIBM7/375-411                 ...............KGIFVYDTNKNF....I.......RKYEGVTDAQRDLNISHST.IKKYA........
Q8SDA6_BPDPK/275-312                 ...............TPIEVTDTILNT....T.......KVYPSIPHFARDVGIKHPNtVRRAI........
M2TER9_COCH5/203-239                 ...............KKVYVYDSNKQF....I.......KCYDSIKFAVNDLHIAFET.IKKYL........
H9CNL3_TALSN/227-263                 ...............KPIVLYNKDGTV....Y.......GEYSSIVEVSNSLNCSVKT.ISRAL........
YL245_MIMIV/111-146                  ...............KKIHQYDINGNY....I.......DSFESINNAGLYTGINPKH.I----sst.....
M2UAP3_COCH5/184-219                 ...............-PVYIYDSYKNL....I.......AIYPSVKTLSKKVGANSTT.IVNYI........
R5F2K5_9CLOT/88-119                  ............knl--------DGEI....V.......GEFLSIAHASRSLKISRRS.LSCAL........
Q02656_PODAN/222-258                 ...............MKVEVTNVDTKE....V.......TVYSSISAAAKALGYRQPS.LSLYL........
Q9B6E2_YARLI/254-291                 ...............IPIFIYDVNTLN...lL.......YIFESKQDMYNKLHIHHIT.LNKCL........
Q98474_PBCV1/290-327                 ............kyd---------DKKt.mrIkvs.idgVEYKSLSEASKILGISRQT.ITY--........
R5K3J2_9CLOT/5-34                    .......nnvyhydd------------....-.......KTFSSIKALAAYTGINEKT.LT---a.......
E7E828_OGAPD/468-505                 ...............---YAYNIDDEF....Ntk...lrYKFNSQSETAKFFNISRMS.MYRYL........
H9CNN1_TALSN/19-55                   ...............KKVYIYDNNKEF....I.......KSYDSVGIAVKELHISSET.IKKYL........
H6D5D8_NECH7/282-318                 ...............YPVYVYNSFKEL....V.......VIFPSVSTLANQINSNHLT.IV---svi.....
K5VGN3_AGABU/247-278                 ..........sdegf----------KL....I.......GSFVSTRRAANFLEISHST.VRRY-m.......
K5WG41_AGABU/300-336                 ...............KAVFVYNKNKEF....I.......CKFEGVTHAGKELNINHSV.IKKYA........
A7UG03_PHANO/202-238                 ...............KRVEVTDVETKE....V.......TVYSSITAAARALCYRQAS.ISLYL........
Q02677_PODAN/251-291                 ..............y-LVNIYEKSDSKgfqlI.......GSFVSIRRAAKFLGISSNT.IRLYI........
A5J071_GIBZA/78-111                  ..............g--VGIFDLEDNL....I.......KKFDNNVELANYLNISKVT.V----vv......
A5J066_GIBZA/386-422                 ...............KGIFVYDTNKNF....I.......RKYEGVTDAQRDLNISHST.IKKYA........
Q184B9_PEPD6/61-97                   ...............KSIKVFNIETGE....V.......RIFKSAKAASKYLKISADY.ASC--la......
A0A0D1E0P9_USTMA/181-210             ..........lypel------------....T.......KKYDSLNSLAKDIKGDRAT.IRKYV........
A5J057_GIBZA/287-317                 .........kddssk------------....N.......LEFSSLTSLANHLKGDRVT.IRQYL........
R7BK61_9FIRM/129-164                 ..vslkksrgviige------------....-.......DKFNSIKSAQEHFGVSYDT.IKK--w.......
H6D5G2_GIBM7/291-327                 ...............YPVYIYDSFKNL....L.......VIFPSVSSLAHLIKSNHPT.IVEAI........
K5WG41_AGABU/212-248                 ...............YPVYIYNSFREL....L.......VIFPSVKTLAKLINSNHST.IVSFI........
Q89820_PBCV1/191-227                 ...............KCVYQFDMNGNF....I.......QSFQTVAEAAEYLGKVHGG.IASCA........
R7HLP8_9FIRM/131-167                 ...............TPILQYDLEGNF....I.......REYKSINEASKETNLD---.-----irhisrni
E4ZQ93_LEPMJ/321-357                 ...............YSVYVYNSFKEL....L.......VIFPSVKTLAKLIKSNSST.L----vdvi....
A0A0B5ATB2_9BACL/104-139             ...............-KIFQYDLEGNF....I.......ASYSNIVEASRVTGASQPG.ISQ--vi......
F7WD59_SORMK/32-63                   .........dsegfq-----------L....I.......GSFVSIRRAGKFLGISSNT.VRLYI........
YL245_MIMIV/278-314                  ..............v-KVAQYDMNYNV....I.......TSYASIKEAGEKTGIDKSS.IV---rvc.....
Q02691_PODAN/288-324                 ...............YPVYIYNSFKAL....L.......VIFPSVSTIANLIKSNHHT.IVDAI........
E7E828_OGAPD/717-753                 .............vd--IYCYDLNNNL....I.......TQFESITLASMFFKVSKST.IMRH-v.......
M7U6C3_BOTF1/40-74                   ..............v-EVVVTDLETKL....T.......STYESIRKAAKAINSD---.-----ikslsl..
A7UG03_PHANO/129-165                 ...............IEVEVTDLETSN....T.......STYHAIRAAARALDIDKRY.IEHYV........
Q02697_PODAN/179-219                 ...............IPVYLYTYSEGSlkdnY.......IKFESINKLSQYLNISRET.INIYL........
F2WVM0_MONRO/158-194                 ..............r-PVVLYNLNGTI....F.......GEFPTILEAAKAINCNEKT.IRRAL........
C6XYU6_PEDHD/105-140                 ..............t--VGQYDLQGNL....I.......RTFANTIEAAKAVGVHKNG.IRD--vi......
Q24LE1_BPPCD/41-77                   ...............KPIKVFNIETGE....V.......RIFKSAKAASKYLKISGDY.AS---cla.....
M2UAN9_COCH5/179-218                 ...............-PVNIYEKSSSKgfelI.......GSFVSARRAAKFLGISGST.VIRY-m.......
M2SI39_COCH5/141-177                 ...............KKVVFTNIETNE....K.......LVFNSFRDASLNMKISRNT.INKYL........
MOBB_BPT4/213-249                    ..............v-PVFQYDTTGKL....L.......RVFPRIKDAAVSVKGCMSN.IKKCI........
Q02714_PODAN/559-598                 ...............IKVYAYNAITLDl.inN.......EPFSSLSDTADYFNVNYRT.ITRHL........
H9CNM8_TALSN/354-390                 ...............KAVFVYDTNRKF....I.......GKYEGVTDAQKALNISHST.IKKYA........
Q8SDA6_BPDPK/130-166                 ..............r-RVIATDVTTGE....K.......TTYYSMSELARALGVNKNT.VWVII........
D5GDY0_TUBMM/219-256                 ...............TPIFVYDANDFT...lL.......YVFDSKNYMYNTINIHHKT.FNDCI........
Q02697_PODAN/260-299                 ...............KKVWVYSIDTKSn.ivK.......NIYNSIGETIKILNVSHNL.VNNHL........
F7WD43_SORMK/269-305                 ...............YPVYIYNSFKKL....L.......IIFPSVGTLAKLIKSNHPT.IVN--vi......
Q02671_PODAN/177-213                 ...............ISFVVNDLEKKT....L.......TEFSSLRAAARELHIAEVS.IKKYL........
D5GGC2_TUBMM/192-228                 ...............YPVYIYNSYREL....L.......VVFPSVTTLAKLINSNHST.IVSYI........
F7WD45_SORMK/199-236                 ..............l--VFVYDVNSPN....Kd.....pIVYSSINRALKGLQISHST.LLNYI........
IEND1_NEUCR/251-287                  ..............l-GVGIYDLEDNL....I.......LKFSNNVELAKYLGISKVT.VGKYL........
C6Q1R8_9CLOT/484-517                 ......aekkalisa------------....I.......KKYKSCRKAAKALGVSHTTiINK--l.......
H9CNU2_PENMQ/287-323                 ...............YPVYIYNSYKKL....L.......VIFPSVLTLSKLINSNHPT.IIN--vi......
A5J057_GIBZA/193-230                 ...............TPVYIYNVEDFT...lL.......YIFESKQHMYDSISIHHKT.LNNCL........
R5T3B0_9CLOT/139-174                 ......dklkqylyy----------NS....N.......KNYPTTKELAQILNCDEKT.VNKIL........
R5IL14_9CLOT/84-118                  ...........pliq-----LTLDGQV....V.......AEYLSIAHASRALNISRRS.ISC--a.......
O41133_PBCV1/173-210                 ...............KKVYQYDMDGKY....I.......GWFDSCEEAARHLEKSDGSdISKCA........
H9CNU2_PENMQ/371-407                 ...............KAVFVYDANRKF....I.......GKYEGVTDAQKALKINHST.IKKYA........
TEV2_BPT4/159-196                    srtakktvsialksg------------....-.......NKFRSFKSAAKFLKCSEEQ.VSNH-........
F7WD39_SORMK/158-194                 ...............KPVILSNLNGTI....Y.......GKYPTILDASKAINCNEKT.IRRAL........
A5J040_GIBZA/215-249                 .............ld--VEITDIETKI....T.......TTYSSVREAASYLNSDIKT.-----llr.....
YMRF1_YEAST/418-454                  ..............v-GVFVYDLNNTL....I.......MTFTGYRPAATYFNCSKHE.IAKYI........
H9CNS7_PENMQ/244-280                 ...............KPIILYNKDGTV....Y.......GEYSSIVEASNSLNCSIKS.ISRAL........
R6KFR2_9CLOT/88-119                  ............knl--------DGEI....V.......GEFLSIAHASRSLKISRRS.LSCAL........
Q84603_PBCV1/215-251                 ...............KIVYQYDLDGMY....I.......DKFRSCREAGRSLGKGHKY.ITECV........
BI1_USTMA/359-394                    ..............p--VTIINLDGTN....I.......MNFVSIKEASIAISCNEKT.IRRAL........
Q18AB6_PEPD6/61-97                   ...............KPIKVFNIETGE....V.......RIFKSAKAASKYLKISADY.ASC--la......
D7GWF6_9FIRM/139-173                 ..............r-PVIQCSADGKF....I.......AKYKSVSEAALKTGANRTT.IS---g.......
Q02691_PODAN/372-408                 ...............KAVFVYDINRKF....I.......GKYDGVTDAQKALNLSHST.IKKYA........
H6D5D8_NECH7/366-402                 ...............KAVFVYDTNKNF....I.......SKHQGVTDAQKALNINHST.IKKYA........
F7WD43_SORMK/353-389                 ...............KAVFVYDMNKNF....V.......AKYDGVMEAQRALGISHST.IKNYA........
Q02714_PODAN/481-520                 ...............TKVWAYDALTLD....Li....kgSPFESKTQASNILGISRNV.INYFI........
Q02697_PODAN/337-374                 ..............l-NVWIYNANTLE...lI.......GNFNSIKKAADYFNVDYRS.LINH-l.......
A0A0B5ATB2_9BACL/336-372             .............lt--VSQFTTDGQF....V.......KEYDSIREATEELGLGYVQ.INQAI........
MOBB_BPT4/129-166                    ...............KPIYQYDLNGNF....I.......RKYRCITDAAEDMSYSCSTsIKQCV........
#=GC seq_cons                        .................lhlashppph....l.......spasSlpcAu+tlshscpT.Ipphh........
//
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