GenomeNet

Database: Pfam
Entry: Nup_retrotrp_bd
LinkDB: Nup_retrotrp_bd
Original site: Nup_retrotrp_bd 
#=GF ID   Nup_retrotrp_bd
#=GF AC   PF10599.6
#=GF DE   Retro-transposon transporting motif  
#=GF AU   Wood V, Coggill P
#=GF SE   Wood V
#=GF GA   25.00 25.00;
#=GF TC   25.60 25.60;
#=GF NC   23.40 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   17615301
#=GF RT   Multiple conserved domains of the nucleoporin Nup124p and its
#=GF RT   orthologs Nup1p and Nup153 are critical for nuclear import and
#=GF RT   activity of the fission yeast Tf1 retrotransposon. 
#=GF RA   Sistla S, Pang JV, Wang CX, Balasundaram D; 
#=GF RL   Mol Biol Cell. 2007;18:3692-3708.
#=GF DR   INTERPRO; IPR018892;
#=GF CC   This is the highly conserved C-terminal motif GRKIxxxxxRRKx of
#=GF CC   nucleoporins that plays a critical and unique role in the
#=GF CC   nuclear import of retro-transposons in both yeasts and higher
#=GF CC   organisms. It would appear that the arginine residues at
#=GF CC   positions 2 and 9-10 constitute a bipartite nuclear localisation
#=GF CC   signal, with two basic peptide motifs separated by an
#=GF CC   interchangeable spacer sequence, that is crucial for the
#=GF CC   retro-transposon activity [1].
#=GF SQ   52
#=GS F7EUV5_ORNAN/1376-1466      AC F7EUV5.2
#=GS L5LVD6_MYODS/1157-1248      AC L5LVD6.1
#=GS E9Q3G8_MOUSE/1372-1462      AC E9Q3G8.1
#=GS I3M6R8_SPETR/1379-1469      AC I3M6R8.1
#=GS G1L1N5_AILME/1384-1476      AC G1L1N5.1
#=GS G1KCK7_ANOCA/1343-1427      AC G1KCK7.1
#=GS G3V662_RAT/1378-1468        AC G3V662.1
#=GS U3IHS3_ANAPL/69-156         AC U3IHS3.1
#=GS G1QKG7_NOMLE/1386-1475      AC G1QKG7.1
#=GS J9JHY9_CANFA/1367-1458      AC J9JHY9.1
#=GS S9XAR9_SCHCR/1120-1200      AC S9XAR9.1
#=GS A0A091DU79_FUKDA/3181-3271  AC A0A091DU79.1
#=GS G1SIZ4_RABIT/1383-1473      AC G1SIZ4.2
#=GS F1NWC8_CHICK/1324-1411      AC F1NWC8.2
#=GS H0XC65_OTOGA/1415-1507      AC H0XC65.1
#=GS I3LEL0_PIG/1387-1477        AC I3LEL0.1
#=GS H2PI06_PONAB/1350-1439      AC H2PI06.1
#=GS NU124_SCHPO/1072-1159       AC Q09904.1
#=GS G3RSS3_GORGO/1386-1476      AC G3RSS3.1
#=GS H0Z6B1_TAEGU/1332-1419      AC H0Z6B1.1
#=GS L8YAU1_TUPCH/857-920        AC L8YAU1.1
#=GS H2R1J5_PANTR/1416-1506      AC H2R1J5.1
#=GS F7BCM6_MONDO/1366-1456      AC F7BCM6.2
#=GS G3RED7_GORGO/1416-1506      AC G3RED7.1
#=GS NU153_RAT/1378-1468         AC P49791.1
#=GS F7EHG8_CALJA/1381-1470      AC F7EHG8.1
#=GS H0V265_CAVPO/1381-1472      AC H0V265.1
#=GS E2RLN2_CANFA/1387-1478      AC E2RLN2.2
#=GS F6V9A5_MACMU/1343-1432      AC F6V9A5.1
#=GS G1P376_MYOLU/1421-1511      AC G1P376.1
#=GS E1BIX5_BOVIN/1393-1485      AC E1BIX5.2
#=GS J9NV51_CANFA/1251-1342      AC J9NV51.1
#=GS NU153_HUMAN/1385-1475       AC P49790.2
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D Q; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D R; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D N; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0C B; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D O; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D M; 1410-1418;
#=GS NU153_HUMAN/1385-1475       DR PDB; 4U0D P; 1410-1418;
#=GS Q6BZ26_DEBHA/940-1045       AC Q6BZ26.2
#=GS G3GUG1_CRIGR/1235-1326      AC G3GUG1.1
#=GS U3KG17_FICAL/1304-1390      AC U3KG17.1
#=GS M3WFC8_FELCA/1398-1488      AC M3WFC8.1
#=GS W5PPG7_SHEEP/1376-1467      AC W5PPG7.1
#=GS F7DUR1_HORSE/1374-1465      AC F7DUR1.1
#=GS G3U2A5_LOXAF/1382-1472      AC G3U2A5.1
#=GS A0A0D9R5K0_CHLSB/1384-1473  AC A0A0D9R5K0.1
#=GS G5AXT4_HETGA/1414-1504      AC G5AXT4.1
#=GS H3ACD6_LATCH/1363-1449      AC H3ACD6.1
#=GS A5DA71_PICGU/906-969        AC A5DA71.2
#=GS F6V9C1_MACMU/1385-1474      AC F6V9C1.1
#=GS F7EI13_CALJA/946-1036       AC F7EI13.1
#=GS F7C363_XENTR/1340-1422      AC F7C363.1
#=GS G7P4H7_MACFA/1370-1459      AC G7P4H7.1
#=GS A3LRH6_PICST/919-1019       AC A3LRH6.2
#=GS G1MW17_MELGA/1335-1422      AC G1MW17.1
#=GS L5KU23_PTEAL/1382-1469      AC L5KU23.1
#=GS G3TFY7_LOXAF/1392-1482      AC G3TFY7.1
F7EUV5_ORNAN/1376-1466                 sgsapsgs-------GGVFQFG..SS.T.TNFNF........TSNNPTGVFTFGANA.APP.......................APSAQPSSTAGFP....FGPVPAF....-AVGTNGKNVFsa.sgsSVSGRKIKTAVRRRK.
L5LVD6_MYODS/1157-1248                 .....gsg--TAPNSGSVFQFG..SS.T.TNFNF........TNNSPSGVFKFGANP.TTP.......................AAPAQPSGSGGFP....FNQPSAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
E9Q3G8_MOUSE/1372-1462                 .......g-SGTANASSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGASP.STP.......................AASAQPSGSGVFS....FSQSPAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRKK.
I3M6R8_SPETR/1379-1469                 .......s-GAAPNPSSGFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFP....FNQPTAA....FTVGSNGKNMFss.sgtSVPARKIKTAVRRKK.
G1L1N5_AILME/1384-1476                 ......sa--AAPSSGSVFQFGgsSS.T.TNFNF........TNNNPSGVFTFSANP.STP.......................AASAQPSGSGGFP....FNQPSAA....FTVGSNGKNVFss.sgtSVSGRKIKTAVRRRK.
G1KCK7_ANOCA/1343-1427                 .......t-GTTPNSGPVFQFG..NS.A.TSFNF........TGNSP-GVFTFGAAP.GTS.......................---AQPAGSSGFS....FNQ-P-S....FNLGSSGKNMFst.pgsAVSGRKIKTAVRRRK.
G3V662_RAT/1378-1468                   .......g-SGTANASSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGASP.STP.......................AAAAQPSGSGGFS....FSQSPAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRKK.
U3IHS3_ANAPL/69-156                    .......g-SGTSSAGPVFQFG..SN.T.SNFNF........PNNP--GVFTFGANP.TAP.......................TASAQPSGSSGFS....FSQPPAF....-TVGTNGKNIFsa.sgsSVSGRKIKTAFRRRK.
G1QKG7_NOMLE/1386-1475                 .......s-GTTPNSSSVFQFG..SS.A.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss..gtSVSGRKIKTAVRRRK.
J9JHY9_CANFA/1367-1458                 ....gsat---APSSGSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFP....FSQSSPA....FTMGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
S9XAR9_SCHCR/1120-1200                 .......a-----------NLG..NT.T.PAFSFga....sqPSNPPNAGFSFSG-A.STP.......................AFSAGSSTTQSPA...pQTQSGIQ....FNLGSTNEQPN......PPAGRKIAVPRSRRKr
A0A091DU79_FUKDA/3181-3271             .......s-GTTANSSSAFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGSFP....FSQSSAA....FTVGSNGKNMFss.sgtSVPGRKIKTAVRRRK.
G1SIZ4_RABIT/1383-1473                 ......sg--TAPNSNSVFQFG..SS.T.ANFNF........TSNNPAGVFTFGANF.STP.......................AASTQPSGSGSFP....FNPSQAT....FTVGSNGKSMFss.sgtSVSGRKIKTAVRRKK.
F1NWC8_CHICK/1324-1411                 .......g-SGTSSTGPVFQFG..SS.T.SNFNF........TSNPE--VFTFGANP.PAP.......................AASVQPSGSSGFS....FSQPPAF....-TVGTNGKNIFsa.sgsSVSVRKIKTAVRRRK.
H0XC65_OTOGA/1415-1507                 .....gsg--TAPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFS....FNQSPAA....FTLGSNGKNMFsssgtsVTAGRKIKTAVRRRK.
I3LEL0_PIG/1387-1477                   ......sg--TAPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.SIP.......................AASAQPSGSGGFP....FNQSPGA....FTVGSNGKNIFss.sgtSLSGRKIKTAVRRRK.
H2PI06_PONAB/1350-1439                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKSVFss..gtSGSGRKIKTAVRRRK.
NU124_SCHPO/1072-1159                  .......a-GNTPNPSGSIN--..NA.S.QAFAFgsgepsnpASNPPSTGFSFGA--.---.......................---ATPSAFNASA....-SQSPAPngiqFNLGSSNSQTN......APPGRKIAVPRSRRKr
G3RSS3_GORGO/1386-1476                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPPGVFTFGANS.STP.......................AASAQPSGSGGFS....FNQSPAA....FTVGSNGKNVFss.sgtSFSGRKIKTAVRRRK.
H0Z6B1_TAEGU/1332-1419                 .......g-SGTPSAGSVFQFG..SN.A.TNFSF........PNNP--GVFTFGANP.PAS.......................AAPAPPSGTLGFS....FNQPP-T....FTVGTNGKNVFsa.sgsSVPGRKIKTAIRRRK.
L8YAU1_TUPCH/857-920                   .......s-GAAPNTGSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AACVQPSGSGGFP....FNQAPPA....FTVG-------......---------------.
H2R1J5_PANTR/1416-1506                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGAFP....FNQSPAA....FTVGSNGKNVFss.sgtSFSGRKIKTAVRRRK.
F7BCM6_MONDO/1366-1456                 .......s-GTTPNSSSVFHFG..SS.T.ANFNF........TNNNPSGVFTFGANA.GTP.......................AASAQPSGSAVFP....FNPSPAA....FTVGTNGKNMFsa.sgtSVSGRKIKTAVRRRK.
G3RED7_GORGO/1416-1506                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPPGVFTFGANS.STP.......................AASAQPSGSGGFS....FNQSPAA....FTVGSNGKNVFss.sgtSFSGRKIKTAVRRRK.
NU153_RAT/1378-1468                    .......g-SGTANASSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGASP.STP.......................AAAAQPSGSGGFS....FSQSPAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRKK.
F7EHG8_CALJA/1381-1470                 .......s-GTTANSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNPSPAF....-TVGSNGKNVFss.sgtAVPGRKIKTAVRRRK.
H0V265_CAVPO/1381-1472                 .......s-GTTPNSSSVFQFG..SSsT.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGNFP....FSQSAAA....FTVGSNGKNMFss.pgtSVPGRKIKTAVRRKK.
E2RLN2_CANFA/1387-1478                 ....gsat---APSSGSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFP....FSQSSPA....FTMGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
F6V9A5_MACMU/1343-1432                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss..gtSVSGRKIKTAVRRRK.
G1P376_MYOLU/1421-1511                 .....gsg--TAPNSGSVFQFG..SS.T.TNFNF........TNNSPSGVFKFGANP.STP.......................AAPAQPSGSG-FP....FNQPSAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
E1BIX5_BOVIN/1393-1485                 .....gsg--TAPNPSSVFQFG..SS.TaTNFNF........TNSSPSGVFTFGASP.STP.......................AASSQPSGSGGFQ....FSQSSAA....FTVGSNGKNMFss.sgpSVSGRKIKTAVRRKK.
J9NV51_CANFA/1251-1342                 ....gsat---APSSGSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFP....FSQSSPA....FTMGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
NU153_HUMAN/1385-1475                  .......s-GTTPNSSSAFQFG..SS.T.TNFNF........TNNSPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss.sgtSFSGRKIKTAVRRRK.
#=GR NU153_HUMAN/1385-1475       SS    .......X-XXXXXXXXXXXXX..X-.-.S-S--........XXXXXXXXXXXXXXX.XXX.......................XXXXXXXXXXXXX....XXXXXXX....XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX.
Q6BZ26_DEBHA/940-1045                  ........KEGTPDPASIFGGG..AN.N.MNTSNiqngvnglNKSAESSPFGFNAHQ.STPdfkfangiqqpqfnsglpadmnnQSFNSTSGMTPPT....LSTTPPI....-----------......IKSNRKIAQMRSRRR.
G3GUG1_CRIGR/1235-1326                 .....gsg--TAPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.STP.......................AASAQPSGSGGFQ....FSQSPAS....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
U3KG17_FICAL/1304-1390                 .......g-SGTPGAGSVFQFG..SS.T.TNFSF........TNNP--GVFTFGASP.SAA.......................AAPAPPSGTAGFS....FNQ-P-T....FTVGTNGKNVFsa.sgsSVPGRKIKTAVRRRK.
M3WFC8_FELCA/1398-1488                 ......sa--AAPSSTSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.SAP.......................AAAAQPSGSGGFP....FSHPAAA....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRKK.
W5PPG7_SHEEP/1376-1467                 ......sg--TAPNSSSIFQFG..SS.TaTNFNF........TNNNPSGVFTFGASP.STP.......................AASAQPSGSGGFQ....FSQASAA....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRKK.
F7DUR1_HORSE/1374-1465                 .....gsg--TAPNSSKSFQFG..ST.T.TNFNF........TNNNPPGVFTFGANP.STP.......................AASAQPSGSGGFP....FSQSPAA....FTVGSNGKNMFss.sgtSVPGRKIKTAVRRRK.
G3U2A5_LOXAF/1382-1472                 .......s-GAAPNSSSGFQFG..SS.T.TNFNF........TNNNPSGVFTFGANA.STP.......................AASAQPSGSGGFP....FSQPSAG....FTVGSNGKNVFss.sgtPVSGRKIKTAVRRRK.
A0A0D9R5K0_CHLSB/1384-1473             .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss..gtSVSGRKIKTAVRRRK.
G5AXT4_HETGA/1414-1504                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANP.SIP.......................AASAQPSGSGSFP....FSQSSAA....FTVGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
H3ACD6_LATCH/1363-1449                 ..asaapl-----NSSGGFQFG..AN.N.AGYNF........SGTNPSGVFTFGSNS.GGS.......................SAPAAPGSAVGFQ....F-NQPAF....-TVGAVGKTPGq....hSISGRKIKTAIRRRK.
A5DA71_PICGU/906-969                   ........REPTPDPASIFGAG..SS.N.T----........RESTPAAPLGFAT--.---.......................QNQNPNTSFTPPP....LSGNP--....-----------......MVRNRKIAQMRSRRR.
F6V9C1_MACMU/1385-1474                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss..gtSVSGRKIKTAVRRRK.
F7EI13_CALJA/946-1036                  ......gs-GTTANSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNPSPAF....-TVGSNGKNVFss.sgtAVPGRKIKTAVRRRK.
F7C363_XENTR/1340-1422                 .......s-SAAPSAGSGFQFG..NN.-.TNFNF.......tTPNSSGGVFTFGANAgSTP.......................QPPAPGFMFNAAA....-----SG....FNVGTNGRSTPa....sSISNRKIKTARRRK-.
G7P4H7_MACFA/1370-1459                 .......s-GTTPNSSSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANS.STP.......................AASAQPSGSGGFP....FNQSPAA....FTVGSNGKNVFss..gtSVSGRKIKTAVRRRK.
A3LRH6_PICST/919-1019                  ........KEATPDPASVFGMN..NS.N.AN---........MGSREATPFAFGTGT.GVSnp...................asVFGNPGNAISMPAptagFGGTPAFafggVNGGAGGSLAPnqtptpPLQGRMIARMRQRRR.
G1MW17_MELGA/1335-1422                 .......g-SSTSSAGPVFQFG..SS.T.SNFNF........TSNPE--VFTFGANP.PAP.......................AAPVQPSGSSGFS....FSQPP-T....FTVGTNGKNIFsa.sgsSVSGRKIKTAVRRRK.
L5KU23_PTEAL/1382-1469                 .....gsg--TAPNSSSIFQFA..RS.A.TNFSF........TNNNASGIFTFGANP.STP.......................AASAQPSGSGGFP....----SAA....FTLGSNGKNMFss.sgtSVSGRKIKTAVRRRK.
G3TFY7_LOXAF/1392-1482                 .......s-GAAPNSSSGFQFG..SS.T.TNFNF........TNNNPSGVFTFGANA.STP.......................AASAQPSGSGGFP....FSQPSAG....FTVGSNGKNVFss.sgtPVSGRKIKTAVRRRK.
#=GC SS_cons                           .......X-XXXXXXXXXXXXX..X-.-.S-S--........XXXXXXXXXXXXXXX.XXX.......................XXXXXXXXXXXXX....XXXXXXX....XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX.
#=GC seq_cons                          .......u.tssPNSoSVFQFG..SS.T.TNFNF........TNNNPSGVFTFGANs.STP.......................AASAQPSGSGGFs....FsQoPAu....FTVGSNGKNhFSS.SGTSVSGRKIKTAVRRRK.
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