GenomeNet

Database: Pfam
Entry: PF08558
LinkDB: PF08558
Original site: PF08558 
#=GF ID   TRF
#=GF AC   PF08558.5
#=GF DE   Telomere repeat binding factor (TRF)
#=GF AU   Daub J, Wood V
#=GF SE   Pfam-B_8956 (release 18.0) 
#=GF GA   25.00 25.00;
#=GF TC   27.10 25.00;
#=GF NC   24.80 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15316005
#=GF RT   TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2
#=GF RT   complex on telomeres. 
#=GF RA   Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky
#=GF RA   AN, Chait BT, de Lange T; 
#=GF RL   J Biol Chem 2004;279:47264-47271.
#=GF RN   [2]
#=GF RM   9034194
#=GF RT   Regulation of telomere length and function by a Myb-domain
#=GF RT   protein in fission yeast. 
#=GF RA   Cooper JP, Nimmo ER, Allshire RC, Cech TR; 
#=GF RL   Nature 1997;385:744-747.
#=GF RN   [3]
#=GF RM   11545737
#=GF RT   Structure of the TRFH dimerization domain of the human telomeric
#=GF RT   proteins TRF1 and TRF2. 
#=GF RA   Fairall L, Chapman L, Moss H, de Lange T, Rhodes D; 
#=GF RL   Mol Cell 2001;8:351-361.
#=GF RN   [4]
#=GF RM   17977837
#=GF RT   Identification and characterization of an essential telomeric
#=GF RT   repeat binding factor in fission yeast. 
#=GF RA   Pitt CW, Valente LP, Rhodes D, Simonsson T; 
#=GF RL   J Biol Chem. 2008;283:2693-2701.
#=GF DR   INTERPRO; IPR013867;
#=GF DR   SCOP; 1h6p; fa;
#=GF CC   Telomere repeat binding factor (TRF) family proteins are
#=GF CC   important for the regulation of telomere stability. The two
#=GF CC   related human TRF proteins hTRF1 and hTRF2 form homodimers and
#=GF CC   bind directly to telomeric TTAGGG repeats via the myb DNA
#=GF CC   binding domain Pfam:PF00249 at the carboxy terminus [1]. TRF1 is
#=GF CC   implicated in telomere length regulation and TRF2 in telomere
#=GF CC   protection [1]. Other telomere complex associated proteins are
#=GF CC   recruited through their interaction with either TRF1 or TRF2.
#=GF CC   The fission yeast protein Taz1p (telomere-associated in
#=GF CC   Schizosaccharomyces pombe) has similarity to both hTRF1 and
#=GF CC   hTRF2 and may perform the dual functions of TRF1 and TRF2 at
#=GF CC   fission yeast telomeres [2]. This domain is composed of multiple
#=GF CC   alpha helices [3] arranged in a solenoid conformation similar to
#=GF CC   TPR repeats. The fungal members have now also been found to
#=GF CC   carry two double strand telomeric repeat binding factors [4].
#=GF SQ   262
#=GS C4YIA4_CANAW/316-594  AC C4YIA4.1
#=GS F7FBB4_MONDO/22-222   AC F7FBB4.1
#=GS F1NCI9_CHICK/37-236   AC F1NCI9.1
#=GS C5GJ43_AJEDR/186-424  AC C5GJ43.1
#=GS B5VT37_YEAS6/29-306   AC B5VT37.1
#=GS C8ZIQ2_YEAS8/29-306   AC C8ZIQ2.1
#=GS G3SB61_GORGO/71-267   AC G3SB61.1
#=GS F7EEI0_MACMU/72-269   AC F7EEI0.1
#=GS A8K914_HUMAN/74-271   AC A8K914.1
#=GS G3X7V3_BOVIN/70-267   AC G3X7V3.1
#=GS F2S1Y4_TRIT1/171-409  AC F2S1Y4.1
#=GS Q5AHJ5_CANAL/316-594  AC Q5AHJ5.1
#=GS C9SAI4_VERA1/130-374  AC C9SAI4.1
#=GS G1P7C4_MYOLU/89-288   AC G1P7C4.1
#=GS H6C6B2_EXODN/120-358  AC H6C6B2.1
#=GS G2WWM8_VERDV/130-374  AC G2WWM8.1
#=GS F0X6T3_GROCL/168-372  AC F0X6T3.1
#=GS G1PJZ4_MYOLU/70-270   AC G1PJZ4.1
#=GS Q5AHX1_CANAL/316-594  AC Q5AHX1.1
#=GS B5X605_SALSA/9-119    AC B5X605.1
#=GS E7EWM7_HUMAN/4-167    AC E7EWM7.1
#=GS A7TKY5_VANPO/26-307   AC A7TKY5.1
#=GS G1R0E7_NOMLE/51-251   AC G1R0E7.1
#=GS TERF1_MOUSE/61-258    AC P70371.1
#=GS G8ZMR4_TORDC/24-303   AC G8ZMR4.1
#=GS G2RGY3_THITE/259-499  AC G2RGY3.1
#=GS F1PBX6_CANFA/1-200    AC F1PBX6.1
#=GS G1XV02_ARTOA/217-451  AC G1XV02.1
#=GS B8QB41_XENLA/23-221   AC B8QB41.1
#=GS H3ABF2_LATCH/1-134    AC H3ABF2.1
#=GS G2WP53_YEASK/29-306   AC G2WP53.1
#=GS Q539Z0_MUNMU/70-267   AC Q539Z0.1
#=GS D5GMT4_TUBMM/1-190    AC D5GMT4.1
#=GS G3AM96_SPAPN/227-502  AC G3AM96.1
#=GS H8WXC0_9ASCO/247-534  AC H8WXC0.1
#=GS Q1WM12_XENLA/23-221   AC Q1WM12.1
#=GS G0WBB8_NAUDC/127-407  AC G0WBB8.1
#=GS F6TLV6_ORNAN/1-135    AC F6TLV6.1
#=GS H0ZMP2_TAEGU/4-204    AC H0ZMP2.1
#=GS B6K1V2_SCHJY/95-333   AC B6K1V2.1
#=GS TAZ1_SCHPO/125-349    AC P79005.1
#=GS H2LVA5_ORYLA/29-162   AC H2LVA5.1
#=GS TERF1_HUMAN/74-271    AC P54274.3
#=GS TERF1_HUMAN/74-271    DR PDB; 3BQO A; 74-268;
#=GS TERF1_HUMAN/74-271    DR PDB; 1H6O A; 74-265;
#=GS TERF1_HUMAN/74-271    DR PDB; 3L82 A; 74-266;
#=GS F1QKQ7_DANRE/29-224   AC F1QKQ7.1
#=GS H0H202_9SACH/29-306   AC H0H202.1
#=GS F2TEN4_AJEDA/186-424  AC F2TEN4.1
#=GS H2U491_TAKRU/2-201    AC H2U491.1
#=GS H2U492_TAKRU/1-195    AC H2U492.1
#=GS F8MNL0_NEUT8/269-507  AC F8MNL0.1
#=GS E9D299_COCPS/178-416  AC E9D299.1
#=GS B8NH48_ASPFN/140-400  AC B8NH48.1
#=GS G4NHA0_MAGO7/375-615  AC G4NHA0.1
#=GS Q7TSK8_MOUSE/61-258   AC Q7TSK8.1
#=GS F7A2U5_MONDO/3-200    AC F7A2U5.1
#=GS B2ZU82_CHICK/25-175   AC B2ZU82.1
#=GS A5DKQ0_PICGU/258-530  AC A5DKQ0.2
#=GS C7GJ82_YEAS2/29-306   AC C7GJ82.1
#=GS Q8CH10_MUSSP/61-254   AC Q8CH10.1
#=GS G1TY99_RABIT/52-252   AC G1TY99.1
#=GS Q5EB98_RAT/61-258     AC Q5EB98.1
#=GS A3LVU7_PICST/169-447  AC A3LVU7.2
#=GS Q6CE73_YARLI/147-379  AC Q6CE73.1
#=GS H3BR06_HUMAN/2-173    AC H3BR06.1
#=GS Q5F3M6_CHICK/25-224   AC Q5F3M6.1
#=GS F7EB98_MACMU/72-269   AC F7EB98.1
#=GS F1RWI3_PIG/70-267     AC F1RWI3.1
#=GS F1MMS4_BOVIN/94-293   AC F1MMS4.2
#=GS F1Q8U5_DANRE/14-210   AC F1Q8U5.1
#=GS Q4FZZ9_DANRE/14-210   AC Q4FZZ9.1
#=GS F2QLG1_PICP7/92-384   AC F2QLG1.1
#=GS C5FJK7_ARTOC/167-405  AC C5FJK7.1
#=GS B0Y0Z4_ASPFC/193-431  AC B0Y0Z4.1
#=GS C0NNV2_AJECG/165-403  AC C0NNV2.1
#=GS B7ZR57_XENLA/16-215   AC B7ZR57.1
#=GS G4UU77_NEUT9/269-510  AC G4UU77.1
#=GS TERF2_MOUSE/97-297    AC O35144.3
#=GS Q71E47_XENLA/16-215   AC Q71E47.2
#=GS E5RFJ5_HUMAN/104-168  AC E5RFJ5.1
#=GS G3SU07_LOXAF/71-268   AC G3SU07.1
#=GS C0SB27_PARBP/147-384  AC C0SB27.1
#=GS B2DFX9_BOVIN/4-67     AC B2DFX9.1
#=GS C6HM22_AJECH/180-418  AC C6HM22.1
#=GS F1S2L2_PIG/52-251     AC F1S2L2.1
#=GS B2B1Z5_PODAN/303-509  AC B2B1Z5.1
#=GS Q539Y8_MUNRE/70-267   AC Q539Y8.1
#=GS Q3MHY0_BOVIN/70-267   AC Q3MHY0.1
#=GS Q6BTS1_DEBHA/349-627  AC Q6BTS1.2
#=GS H0VF28_CAVPO/71-268   AC H0VF28.1
#=GS A7TKR0_VANPO/36-333   AC A7TKR0.1
#=GS Q3V252_MOUSE/61-168   AC Q3V252.1
#=GS F7E8S9_XENTR/16-213   AC F7E8S9.1
#=GS Q539Y7_MUNRE/70-267   AC Q539Y7.1
#=GS F7F093_ORNAN/2-176    AC F7F093.1
#=GS H3BTA7_HUMAN/1-132    AC H3BTA7.1
#=GS G1SIB8_RABIT/70-268   AC G1SIB8.1
#=GS G9KSX6_MUSPF/69-267   AC G9KSX6.1
#=GS Q6CRS7_KLULA/27-307   AC Q6CRS7.1
#=GS E4UMR5_ARTGP/173-412  AC E4UMR5.1
#=GS B8QB40_XENLA/16-215   AC B8QB40.1
#=GS G3BC67_CANTC/178-456  AC G3BC67.1
#=GS D3YZ08_MOUSE/97-297   AC D3YZ08.1
#=GS F6VIR4_MOUSE/1-178    AC F6VIR4.1
#=GS F6XW10_MONDO/17-218   AC F6XW10.1
#=GS B6Q5I5_PENMQ/156-394  AC B6Q5I5.1
#=GS H2RA24_PANTR/52-252   AC H2RA24.1
#=GS E7QLB4_YEASZ/29-306   AC E7QLB4.1
#=GS F6KWE7_RAT/52-252     AC F6KWE7.1
#=GS B6HIX8_PENCW/182-420  AC B6HIX8.1
#=GS G8Y623_PICSO/328-606  AC G8Y623.1
#=GS H1VU70_COLHI/113-352  AC H1VU70.1
#=GS TERF2_HUMAN/52-252    AC Q15554.2
#=GS TERF2_HUMAN/52-252    DR PDB; 3BUA B; 52-245;
#=GS TERF2_HUMAN/52-252    DR PDB; 1H6P B; 1052-1244;
#=GS TERF2_HUMAN/52-252    DR PDB; 3BU8 B; 52-249;
#=GS TERF2_HUMAN/52-252    DR PDB; 3BU8 A; 52-247;
#=GS TERF2_HUMAN/52-252    DR PDB; 3BUA A; 52-245;
#=GS TERF2_HUMAN/52-252    DR PDB; 1H6P A; 52-245;
#=GS TERF2_HUMAN/52-252    DR PDB; 3BUA C; 52-245;
#=GS TERF2_HUMAN/52-252    DR PDB; 3BUA D; 52-245;
#=GS G7NQM2_MACMU/4-179    AC G7NQM2.1
#=GS G1NG40_MELGA/36-235   AC G1NG40.2
#=GS Q4WVB2_ASPFU/193-431  AC Q4WVB2.1
#=GS H0ZCM7_TAEGU/4-202    AC H0ZCM7.1
#=GS I1RCX3_GIBZE/145-371  AC I1RCX3.1
#=GS G3PV88_GASAC/14-198   AC G3PV88.1
#=GS G7MZJ2_MACMU/72-271   AC G7MZJ2.1
#=GS G3SHY3_GORGO/72-269   AC G3SHY3.1
#=GS B3LKU7_YEAS1/29-306   AC B3LKU7.1
#=GS A5DUJ2_LODEL/258-546  AC A5DUJ2.1
#=GS E9PSR8_RAT/91-291     AC E9PSR8.1
#=GS G9NAU5_HYPVG/141-364  AC G9NAU5.1
#=GS G3YE64_ASPNA/180-418  AC G3YE64.1
#=GS E3QWE2_COLGM/141-384  AC E3QWE2.1
#=GS G3I013_CRIGR/28-112   AC G3I013.1
#=GS F6YH07_MONDO/22-222   AC F6YH07.1
#=GS C1GUR5_PARBA/179-417  AC C1GUR5.1
#=GS G9KSX7_MUSPF/2-167    AC G9KSX7.1
#=GS C5DXM7_ZYGRC/26-304   AC C5DXM7.1
#=GS G3QP07_GORGO/52-205   AC G3QP07.1
#=GS F1NEJ5_CHICK/25-224   AC F1NEJ5.1
#=GS H2RKB1_TAKRU/5-201    AC H2RKB1.1
#=GS H2U488_TAKRU/18-216   AC H2U488.1
#=GS F7WAY8_SORMK/270-512  AC F7WAY8.1
#=GS G0VCC8_NAUCC/27-314   AC G0VCC8.1
#=GS H2NER4_PONAB/56-252   AC H2NER4.1
#=GS G3VUW4_SARHA/17-212   AC G3VUW4.1
#=GS F6V5V7_CALJA/49-249   AC F6V5V7.1
#=GS Q2LMV6_XENTR/15-154   AC Q2LMV6.1
#=GS A2RAV5_ASPNC/146-383  AC A2RAV5.1
#=GS Q2GV64_CHAGB/284-525  AC Q2GV64.1
#=GS D4DFY7_TRIVH/176-415  AC D4DFY7.1
#=GS H3A9N7_LATCH/37-250   AC H3A9N7.1
#=GS Q6FJX7_CANGA/32-309   AC Q6FJX7.1
#=GS G7Q1I2_MACFA/9-184    AC G7Q1I2.1
#=GS F7IQX6_CALJA/71-268   AC F7IQX6.1
#=GS E9ENU1_METAR/138-374  AC E9ENU1.1
#=GS Q5BH27_EMENI/197-435  AC Q5BH27.1
#=GS H2U490_TAKRU/2-201    AC H2U490.1
#=GS Q8X0L3_NEUCS/270-508  AC Q8X0L3.1
#=GS Q1K5E8_NEUCR/270-508  AC Q1K5E8.1
#=GS A6ZWC4_YEAS7/29-306   AC A6ZWC4.1
#=GS H0ZCM5_TAEGU/12-207   AC H0ZCM5.1
#=GS H2AZB9_KAZAF/33-312   AC H2AZB9.1
#=GS Q539Y9_MUNMU/70-267   AC Q539Y9.1
#=GS E7R690_PICAD/202-502  AC E7R690.1
#=GS TBF1_YEAST/29-306     AC Q02457.2
#=GS Q8JGS4_DANRE/14-210   AC Q8JGS4.1
#=GS B8LTG8_TALSN/193-431  AC B8LTG8.1
#=GS G3JEU7_CORMM/137-364  AC G3JEU7.1
#=GS Q539Y6_MUNMU/52-251   AC Q539Y6.1
#=GS C1GE42_PARBD/147-384  AC C1GE42.1
#=GS Q71M47_CHICK/37-236   AC Q71M47.1
#=GS C5PD10_COCP7/178-416  AC C5PD10.1
#=GS A1DE41_NEOFI/181-419  AC A1DE41.1
#=GS F6T659_HORSE/70-267   AC F6T659.1
#=GS G3RM03_GORGO/30-187   AC G3RM03.1
#=GS E7KVI1_YEASL/29-306   AC E7KVI1.1
#=GS A1CBA1_ASPCL/180-418  AC A1CBA1.1
#=GS E9QM06_MOUSE/97-297   AC E9QM06.1
#=GS G2QPB3_THIHA/246-487  AC G2QPB3.1
#=GS G3WL30_SARHA/70-242   AC G3WL30.1
#=GS F1NSI5_CHICK/27-225   AC F1NSI5.1
#=GS F7F089_ORNAN/2-176    AC F7F089.1
#=GS E7QAA6_YEASB/29-306   AC E7QAA6.1
#=GS Q2LK75_XENLA/16-215   AC Q2LK75.1
#=GS F7FB99_MONDO/22-222   AC F7FB99.1
#=GS Q539Y5_MUNRE/52-251   AC Q539Y5.1
#=GS A6S1Q0_BOTFB/156-390  AC A6S1Q0.1
#=GS A7F6Z9_SCLS1/147-385  AC A7F6Z9.1
#=GS G5AK43_HETGA/58-258   AC G5AK43.1
#=GS C5DEV8_LACTC/34-307   AC C5DEV8.1
#=GS H2PP90_PONAB/73-268   AC H2PP90.1
#=GS C4JRW1_UNCRE/171-400  AC C4JRW1.1
#=GS G0RL26_HYPJQ/142-376  AC G0RL26.1
#=GS F1R8I5_DANRE/50-245   AC F1R8I5.1
#=GS TERF1_CRIGR/74-271    AC O55036.1
#=GS E2R1W7_CANFA/70-270   AC E2R1W7.1
#=GS F6TW69_MACMU/52-249   AC F6TW69.1
#=GS G2XTH2_BOTF4/162-400  AC G2XTH2.1
#=GS TERF2_CHICK/27-225    AC Q9PU53.2
#=GS G3UUZ0_MELGA/25-177   AC G3UUZ0.1
#=GS H0V1J1_CAVPO/94-293   AC H0V1J1.1
#=GS G3I013_CRIGR/106-173  AC G3I013.1
#=GS H2NRC6_PONAB/52-251   AC H2NRC6.1
#=GS Q75C21_ASHGO/34-327   AC Q75C21.1
#=GS B9WB93_CANDC/319-596  AC B9WB93.1
#=GS G5B5U0_HETGA/70-268   AC G5B5U0.1
#=GS G7XT60_ASPKW/146-384  AC G7XT60.1
#=GS G8BDW4_CANPC/257-544  AC G8BDW4.1
#=GS G8BUL2_TETPH/28-350   AC G8BUL2.1
#=GS E7M151_YEASV/29-306   AC E7M151.1
#=GS G8JXM0_ERECY/35-337   AC G8JXM0.1
#=GS H9G7L7_ANOCA/4-196    AC H9G7L7.1
#=GS G1LHE9_AILME/70-270   AC G1LHE9.1
#=GS H3BR37_HUMAN/1-118    AC H3BR37.1
#=GS F9FID1_FUSOF/145-371  AC F9FID1.1
#=GS Q0CW12_ASPTN/175-413  AC Q0CW12.1
#=GS B2Z8W7_PNECA/139-373  AC B2Z8W7.1
#=GS A3KP67_DANRE/17-212   AC A3KP67.1
#=GS H2R473_PANTR/74-271   AC H2R473.1
#=GS G1KPX9_ANOCA/43-242   AC G1KPX9.1
#=GS B8QB44_XENTR/23-222   AC B8QB44.1
#=GS B5XG60_SALSA/22-148   AC B5XG60.1
#=GS A6QU00_AJECN/180-418  AC A6QU00.1
#=GS Q2UEB6_ASPOR/175-435  AC Q2UEB6.1
#=GS G1TE57_RABIT/93-293   AC G1TE57.1
#=GS C5M6U1_CANTT/454-731  AC C5M6U1.1
#=GS Q7T1R9_CHICK/37-236   AC Q7T1R9.1
#=GS Q5R6X2_PONAB/71-267   AC Q5R6X2.1
#=GS D3ZJF7_RAT/91-290     AC D3ZJF7.1
#=GS C4QXZ4_PICPG/92-384   AC C4QXZ4.1
#=GS TRF1_SCHPO/96-332     AC Q6E434.1
#=GS B8QB43_XENTR/16-213   AC B8QB43.1
#=GS H2M8A8_ORYLA/18-194   AC H2M8A8.1
#=GS F2PSD1_TRIEC/171-409  AC F2PSD1.1
#=GS F7IQX2_CALJA/71-268   AC F7IQX2.1
#=GS E7NNT0_YEASO/29-306   AC E7NNT0.1
#=GS B9EM55_SALSA/22-148   AC B9EM55.1
#=GS Q4QRH9_DANRE/14-210   AC Q4QRH9.1
#=GS H0GPI8_9SACH/29-306   AC H0GPI8.1
#=GS H9FHN7_MACMU/12-212   AC H9FHN7.1
#=GS H2PQJ8_PONAB/71-267   AC H2PQJ8.1
#=GS C4XYR9_CLAL4/362-640  AC C4XYR9.1
#=GS F1QDP9_DANRE/32-220   AC F1QDP9.1
#=GS E9DRY6_METAQ/139-374  AC E9DRY6.1
#=GS F6Z552_XENTR/23-222   AC F6Z552.1
#=GS G1LLV1_AILME/27-234   AC G1LLV1.1
#=GS F2SR84_TRIRC/163-402  AC F2SR84.1
#=GS G3URU7_MELGA/36-235   AC G3URU7.1
#=GS F6XW21_MONDO/17-218   AC F6XW21.1
#=GS F7FBA4_MONDO/22-222   AC F7FBA4.1
#=GS G3USR1_MELGA/23-222   AC G3USR1.1
#=GS A7MD83_DANRE/29-224   AC A7MD83.1
#=GS G7PC12_MACFA/72-269   AC G7PC12.1
#=GS H0WSZ2_OTOGA/68-269   AC H0WSZ2.1
#=GS F6RQ75_HORSE/2-178    AC F6RQ75.1
#=GS H0Y0S5_OTOGA/67-257   AC H0Y0S5.1
#=GS C5JEE9_AJEDS/186-424  AC C5JEE9.1
#=GS Q802C2_CHICK/25-224   AC Q802C2.1
#=GS G3WRI4_SARHA/25-228   AC G3WRI4.1
#=GS G8BVU3_TETPH/27-328   AC G8BVU3.1
#=GS F1NCJ0_CHICK/37-236   AC F1NCJ0.1
#=GS F6W9R8_CALJA/1-115    AC F6W9R8.1
#=GS D4B3M3_ARTBC/171-410  AC D4B3M3.1
#=GS F0UMU9_AJEC8/175-413  AC F0UMU9.1
#=GS C7YWH2_NECH7/143-368  AC C7YWH2.1
#=GS G0RYG2_CHATD/286-527  AC G0RYG2.1
#=GS Q3V252_MOUSE/158-229  AC Q3V252.1
#=GS H0WXM7_OTOGA/16-216   AC H0WXM7.1
#=GS B1H237_RAT/91-291     AC B1H237.1
C4YIA4_CANAW/316-594             ........................LINTL.PTLDNL......................ATQLLRTVAT...SPy..qKIIDLASNPDT................SAGATYRDL.TSLFEFTKRLY.....S.EDDP....FLTVEHIApgmwkegeetpsiFKPKQQSIEST..LRKVNLATF.L...AATL..GTME..IGF...FYLNESFLDVFCPSNNldpsnalsnlggyq....................nglqstdspvgarvgKLLKPQATLYLDLKTQAYISAIE.............................................-AGERSKEEILE.DILPDDLHV.YLMSRRNA.............KLLSP..TETDFVWRCKQRKESLL----.NYTEETPLSEQYD..WFTFLRDLFDYVSKNIA.....YLIWGKMGKTMKNRRed..................................................
F7FBB4_MONDO/22-222              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................GRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TISRLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLETIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLGIIR.ERNITHPVIQNFS..YEIFQQKMLRFLESHMDdaepyLLTMAKRALKSESA-sts.................................................
F1NCI9_CHICK/37-236              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAISNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
C5GJ43_AJEDR/186-424             ........................MIQSL.PILDNL......................STQILTLLAQ...SSy..qDLTSIVSEPTS................ESGQAYSTM.RSLFDHTKNVY.....T.SKGS....FLSPRELD.............LTEPNQV--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQYFLEIFVPEGN.................................................RLLKVQGALFLELKTQAYIAAMS.............................................-SGKRSRTELLY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRAYSRRDILLNEVN.NPEAAAALPEKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKSSK---grls................................................
B5VT37_YEAS6/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
C8ZIQ2_YEAS8/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
G3SB61_GORGO/71-267              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSKDFCRT.RNSAEAIIHGL.....S.SPTA....--------.............YQLRMIYVCQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLQEEIQNLIKIQAIAVCME.............................................-NGNFKEAEVFE.RIFGDPNSY.--------.............-----..---------MPLKSKLLVIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
F7EEI0_MACMU/72-269              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
A8K914_HUMAN/74-271              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGP.....S.SLTA....--------.............CQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MSFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
G3X7V3_BOVIN/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYVCQF..LTRIEAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNCVLNeksstFLMKAAAKVVETKR-art.................................................
F2S1Y4_TRIT1/171-409             .......................k-AQSL.PILDNL......................STQILSFIAR...TSf..qDLTTLVSEPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TNKP....FLSASELG.............FTEASQV--EV..IRKANLASF.V...FSLF..GTQE..IGF...AELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPARPKVEILY.ELFPDNLGL.SLLARRPG............tRHPAP..SETDFVKRASSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....ALTTQTKRLNKTR--spt.................................................
Q5AHJ5_CANAL/316-594             ........................LINTL.PTLDNL......................ATQLLRTVAT...SPy..qKIIDLASNPDT................SAGATYRDL.TSLFEFTKRLY.....S.EDDP....FLTVEHIApgmwkegeetpsiFKPKQQSIEST..LRKVNLATF.L...AATL..GTME..IGF...FYLNESFLDVFCPSNNldpsnalsnlggyq....................nglqstdspvgarvgKLLKPQATLYLDLKTQAYISAIE.............................................-AGERSKEEILE.DILPDDLHV.YLMSRRNA.............KLLSP..TETDFVWRCKQRKESLL----.NYTEETPLSEQYD..WFTFLRDLFDYVSKNIA.....YLIWGKMGKTMKNRRed..................................................
C9SAI4_VERA1/130-374             ...................avraa---SL.PALSHF......................ALQILIIVSQq.hSP...hSLSSAIRTHDS................EAATSWVAL.KNLFTSTRQLF.....S.QTDP....VL------.............HSDFFGSICSTdeLRLANLASI.C...CSLTstGRDAdtIDR...RELYKSFFSILLRDGS.................................................ELSNVVSDLFVAAKTQAIIDSVA............................................kGVQETPIDQIIE.EAFPSSLEQ.NLKSRHGG.............SDLTQ..VEQALVTLAYGRKEALFKQIA.EGLDEGNLRSTYE..NEELFRLLGSYLSDELQ.....HFAHIATKYS-----vqlpmr..............................................
G1P7C4_MYOLU/89-288              .......................v-NR--.WVLKFY......................FYEALRAFRS...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSE---ssas................................................
H6C6B2_EXODN/120-358             ......................rl--ESL.ATLDNY......................ASRILTFLAR..lTP...tEALGLSNTPNS................PSTREYVAM.RAVFDPIRRLF.....N.TGTP....FLSSRDLG.............LREASQI--ET..IRKANQAIF.M...SSVF..-TGE..IGL...RDMDRMFLSVFVPDNG.................................................KLLKAQASIYLELKTQGFITAWR.............................................-TGAAPPAVVMA.DLFGPDLDK.AILARRPG............tTALAP..TEQDFLNRLSSRREILLNHVK.N-NTLDQLPFKYR..WEDFSREVSSYLSKNIE.....S--------------aassssavseaqrtdpt...................................
G2WWM8_VERDV/130-374             ...................avraa---SL.PALSHF......................ALQIIIIVSQq.hSP...nSLSSAIRTHDS................EAATSWVAL.KNLFTSTRQLF.....S.QTDP....VLHSDFLG.............------SICSTdeLRLANLASI.C...CSLTstGRDAdtIDR...RELYKSFFSILLRDGS.................................................ELSNVVSDLFVAAKTQAIIDSVA............................................kGVQETPIDQIIE.EAFPASLEQ.NLKSRHGG.............SDLTQ..VEQALVTLAYGRKEALFKQIA.EGLDEGNLRSTYE..NEELFRLLGSYLSDELQ.....HFAHIATKYNV----qlpmr...............................................
F0X6T3_GROCL/168-372             ...................vrsmg----L.SMLGSL......................AVQILHALSE...RPr..pEGLSNLTSADT................ETGRCYRAL.RATFCCARKMF.....S.DSSA....LLIPEELD.............IKELGDQ--ET..IQMANMATI.C...ASVF..DADD..VSL...IDMHDHFLMTFLPESN.................................................ALTEDLATLFLGLKFRTIAGEFQ............................................rLPDDQQRGDFLE.RLFPADLED.QLKQLHPD.............VPLSD..QELAFLREMMAAKDLLLEAAK.TEQS---------..-----------------.....---------------rsthlh..............................................
G1PJZ4_MYOLU/70-270              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFHRA.RDSAEAIIHGL.....S.SLTS....--------.............HQLRTIYICQF..LTRIASGKA.LvlkDAQF..ETDE.rITP...LESALMIWDSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................SGNFKEAEEVFE.RIFGDSDSD.--------.............-----..---------TSLQRKLLMVIS.QKDTFHSFFQHFS..YSHMMEKIKSFVNYVLDeksstFLMKAAAKIVESKR-art.................................................
Q5AHX1_CANAL/316-594             ........................LINTL.PTLDNL......................ATQLLRTVAT...SPy..qKIIDLASNPDT................SAGATYRDL.TSLFEFTKRLY.....S.EDDP....FLTVEHIApgmwkegeetpsiFKPKQQSIEST..LRKVNLATF.L...AATL..GTME..IGF...FYLNESFLDVFCPSNNldpsnalsnlggyq....................nglqstdspvgarvgKLLKPQATLYLDLKTQAYISAIE.............................................-AGERSKEEILE.DILPDDLHV.YLMSRRNA.............KLLSP..TETDFVWRCKQRKELLL----.NYTEETPLSEQYD..WFTFLRDLFDYVSKNIA.....YLIWGKMGKTMKNRRed..................................................
B5X605_SALSA/9-119               hvtddihprlvsnkehcghlvrpl-----.------......................----------...--....-----------................---------.-----------.....-.----....-------Ea..........ndVTPKKIRAIQF..LTRINDGDK.L...DVSF..DSQE.dLTA...LESALSVLDSIREELP.................................................VPQKDLERVHKCIRE--------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------maagklmvkrqgagqdaee.................................
E7EWM7_HUMAN/4-167               ..............iihglsslta-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............CQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
A7TKY5_VANPO/26-307              .......................a-LSSL.SLLDNI......................SNQLLVMLLSdtfTP....DMYSILSEPNTfl............dtPSIKTFHKL.LKLFKYLLEFY.....-.NVDF....LLNVCDLVpgmwypdspvlniMKKYESYIIST..VRKTNLTVY.L...LSYI..GCIH..APL...NQLQEKFFDIFLPNTMfsnsl.......................................lntneQLLRSQWLLYLDMKTQVYINSLKtlkrsd................................tykenndLIENNDRHNLLN.SIFSKAFAN.ELVLRRTRtt........adqTLITR..YETEFAQRHNTRKEDLY----.TYTSLLKLKQDHS..EESFIRSVFDYASKNMS.....LIIWGTKHRNSKSP-ly..................................................
G1R0E7_NOMLE/51-251              .....................vsr-----.WMPKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGKF.R...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTWPKKALKSESA-ass.................................................
TERF1_MOUSE/61-258               .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RDSAEAIIHGL.....H.RLTA....--------.............YQLKTVYICQF..LTRVASGKA.L...DAQF..EVDE.rITP...LESALMIWNSIEKEHD.................................................---KLHDEIKNLIKIQAVAVCME.............................................IGSFKEAEEVFE.RIFGDPEFY.--------.............-----..---------TPLERKLLKIIS.QKDVFHSLFQHFS..YSCMMEKIQSYVGDVLSeksstFLMKAATKVVENEK-art.................................................
G8ZMR4_TORDC/24-303              .......................t-LSSL.SLLDNV......................STQLLRLLVL...NSg.slQVIAILADSMAfl............ssGETEIFQTL.LKLFKQIRMIY.....T.ESSP....LITVHDVApglwypnsappllLKGHEAYIVSA..IRKANILIF.L...LTVL..GCFN..YGF...EFLQDSFLDILCPNTLftgdg......................................svdpngKFLKTQAILYLDLKTQAFISALKdqv......................................gdsdEIPGLKQHEILD.SIFDNGMAD.RLVLRRTGmsv......gdpnEMMLP..SEREFIERCVRRRETLL----.QYSSYKKLVRDYE..WGHFVKELLGYCNKNMG.....LIVWGRKGRGKSPL-ss..................................................
G2RGY3_THITE/259-499             ...................vmrsm---SL.PLLGNV......................AVQILLRLSQ...QPh..aETASLLADADS................DFRKAYDML.LDIFRPTRRAF.....-.SDSP....LLSPDKLD.............IADSEDR--ET..IRMSNLAAT.A...ASVF..GAHD..VSL...QDVHDAFFSIFIPEDG.................................................EYKSSLTALLLCLKTRLLLDALN............................................kPEQPQPVSPLLD.ALFPVDFDS.FLKQRSGD.............SLLNP..EEEALVSQMRERRELLVKSAA.DEPIKKYLETESS..AERFAESLSSFLQGHLG.....VVVDYADRYGVNI--pln.................................................
F1PBX6_CANFA/1-200               .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMARKALKSE---taas................................................
G1XV02_ARTOA/217-451             .......................r-IQSL.PILDNL......................SSQLLSTLLQ...GQf..qDTLITVTQPET................DQGQAYATL.KALFFQTKRLY.....-.SSEA....FLSTDELR.............FQVAEHR--NM..IRQVNLATF.V...TSLF..GSTE..VGF...FHLNRYFLSTFVPEGG.................................................RLLKNQGGLFLGLKTQAYISAID.............................................-TGEKTKEQLLD.DLFEDDIAG.KLTDRRGG............sKELIP..SEIEFLGRVKNRREQLE---R.APLDVPVLREIYP..WQDWLREMIQYVTKHRD.....SILAPTTRRKLK---rlea................................................
B8QB41_XENLA/23-221              .......................i-NQ--.WAFDYY......................FHTAVEAFRS...--....-----------................DRHEDFQEI.RDIVSVLLLRP.....L.ETKA....--------.............QNDCKLRIMQC..ISRIEEGED.P...DCTF..NDNN.nETP...LESAVGLLDIIQEEMP.................................................LDEDLFKTNKQMVKEAAVLVCIK.............................................KQKFDQAIRILK.KYISNYSKR.--------.............-----..----------KLRAELHTIIR.EKNQNHPLITNFS..FTTIKKMIYQLFEKHIDvtdpiLLTIAKKEQKSQC--lsk.................................................
H3ABF2_LATCH/1-134               .......................v-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...DVRF..EKDR.sITP...LESALLIWRLMEREGE................................................iKQNQFFEELKLLLQVQSVAVCME.............................................HGQYHIATEILE.RQFEEDEQN.--------.............-----..-----------LRMKLSMIIN.KRDPYHLFLQNFS..YSHMLQKVKSFIDLILSkdppfFLQKAAAR-------vskikia.............................................
G2WP53_YEASK/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
Q539Z0_MUNMU/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLKTIYVCQF..LTRIAAGKT.P...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVSCVLNeksstFLMKAAAKVVETKR-art.................................................
D5GMT4_TUBMM/1-190               .......................m-----.------......................----------...--....-----------................---------.KTLFDHTKKLY.....-.THEA....FLSADELK.............FEQPEQR--AT..IRRVNLATF.V...SSVF..GSQE..VGF...FHLNEHFLDTFVPDGG.................................................RLLKSQGALYLDLKTQAYISAMS.............................................-TNERGKEDILL.DLFPDDMNS.ILLNRKPG............aKQLTP..SELDFVHRLAQRKQHLM----.MIPDDVNLSEKYV..WQEFLKEVSWYVSKNYE.....SIIRRIRKRKSP---slsn................................................
G3AM96_SPAPN/227-502             ........................LINTL.PTLDNL......................ATQLLRIVAS...GPy..qKIIDLASNPDT................PAGATYRDL.TSLFEFTKRLY.....S.EEDP....FLTVEHIApgmwkegdmtptmFRNREQSIEST..LRKVNLATF.L...AATL..GTIE..VGF...FYLNESFLDVFCPANNlelenalsnmginn....................qslqsgnfsigekvgKLLKPQATLYLDLKTQAYISAIE.............................................-AGERSREEILE.DILPNNLDE.ILLSRRGT.............KALSP..MELDFVDRCNTRKEILL----.--NYEGNLSEEYE..WFTFLKELFDYVGKNVG.....FLIWGKRGRRE----rvhke...............................................
H8WXC0_9ASCO/247-534             ........................LINTL.PTLDNL......................STQLLRIVAK...SSy..kRIIDIASNPET................PEGATYRDL.TSLFEFTKRLY.....S.EEDP....FLTVDHVApgmwhigeetprvFKNKEQSIEST..LRKVNLATF.L...AAAL..GTME..VGF...FYLNESFLDIFCPAHDldikyhlsdtsyldtans.............latsiqtgvgssvgakigRLLKPQAMLYLDLKTQAYISAIE.............................................-AGERSREEILE.DILPDNMDQ.ILLARRNV.............DLLLP..SEVDFVDRCKSRKALLL-NYD.EEQTQVPLSEEFK..WFTFLRDLFDYVSKNMG.....YLIWGKSGKPVREK-kd..................................................
Q1WM12_XENLA/23-221              .......................i-NQ--.WAFDYY......................FHTAVEAFRS...--....-----------................DRHEDFQEI.RDIVSVLLLRP.....L.ETKA....--------.............QNDCKLRIMQC..ISRIEEGED.P...DCTF..NDNN.nETP...LESAVGLLDIIQEEMP.................................................LDEDLFKTNKQMVKEAAVLVCIK.............................................KQKFDQAIRILK.KYISNYSKR.--------.............-----..----------KLRAELHTIIR.EKNQNHPLITNFS..FTTIKKMIYQLFEKHIDvtdpiLLTIAKKEQKSQC--lsk.................................................
G0WBB8_NAUDC/127-407             .......................t-ISSL.CLLDNI......................STQLLRLLIFnagSP....QILALLTDKSTyl............nsGETDIFQTL.LKLFKQVRNIY.....N.SRDP....LLTVHDVApglwfpnspppslLRGHEPYIITA..IRKTNLLTF.L...LTAV..GCFN..YGF...ELLQSSFLDIFCPNTLythgs.......................................genngKFLKSQSILYLDLKTQAFISALKefe......................................nnsnDIPKDKQTELLD.TIFPSDLDT.QLIHRRTGnmitd...sqplnELLTP..SEKDFVERCDRRKENLM----.NFTTFNDLVINYD..WNHFIRELLEYCNKNMG.....LIIWGKKGRGKSP--ly..................................................
F6TLV6_ORNAN/1-135               ........................-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.L...DCSF..DMEA..LTP...LESAIVVLETIKTEFP.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPST.--------.............-----..---------QKLRNDLLNIIR.ERNWAHPVIQNFS..YETFQQKMLRFLESHTDda.epFLLTTAKKVLKS---qsaae...............................................
H0ZMP2_TAEGU/4-204               .....................aae-----.WMLEFA......................CSSLCRHFEE...--....-----------................QSGAEFWRW.RDVAQALINGF.....S.QIPP....--------.............HQKKTVYLCQL..LIRIAQGKT.L...GLQF..ENDP.rISP...LESALSFWTLLEREEI.................................................KLEKLHEEIRRLIQIQIVAVYME.............................................NRYFKEAAEVLE.RLFTDSESD.--------.............-----..---------KPLRVKLATVIK.TKDPYVPLLQSFS..YSLLISKIKSYIELFMKenetnFLRQEATKHVVSKG-lra.................................................
B6K1V2_SCHJY/95-333              ....................vlrt---SLiPTLGNL......................SAVILSMLGK...-Pf..eEASIIVTNPDS................EMGIAFAKV.MNMFRTLKEMY.....-.SEDS....FIYPDAIN.............MKTNAQK--TA..IRRANLAIF.L...AAVY..GALQ..IGF...FHLNENFLEVFAPDGG.................................................KILANQGVLFMELKTQAYISAMA.............................................-QAERSKEEILN.DLFPPDMAQ.QFLLRRRAs..........ltDKLTY..VEKQILEKCAARKDRLA----.NYEPQEDLNEVYP..WGKFLSEIACYIHNNHS.....SISAIPL--------tppsssrrkkk.........................................
TAZ1_SCHPO/125-349               ..............vrsiwdieka-----.------......................----------...--....----------S................LLVNDCQNI.ANMAEQKVMMV.....S.AIFS....--------.............ESSKDIVNPES..FSERLGKET.V...KDLY..EFNE.qLTTkygLEFRTIFFSYIRKYDA.................................................-YWCLFEDLEKPLKSIQFFTGLIdll.......................................dntNKHLTLRSIVLD.ALLSADEED.---SFYGDal........vlfEELVIryFGTDSNPSIDASEFILSCLPY.TSLDALNVVCGQV..WKS--QKICDFLKSTIGntsnsPLQLRASF-------pafvnavih...........................................
H2LVA5_ORYLA/29-162              .....................age-----.WISDFL......................FLTLCRTFKD...--....-----------................GKLEEFNEA.LSVFETISQSP.....S.LKGA....--------.............AGNEKTLICAF..LSRVIHGKQ.L...DVQF..EEDE.hVKP...LMSAFKIWLNLENTVA.................................................-DESLFENITILLLVQSVAVCLE.............................................AGQRSAASSALK.WLQ------.--------.............-----..---------------------.-------------..-----------------.....---------------ehhe................................................
TERF1_HUMAN/74-271               .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............CQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
#=GR TERF1_HUMAN/74-271    SS    .....................HHH-----.HHHHHH......................HHHHHHHHHH...--....-----------................T-HHHHHHH.HHHHHHHHHT-.....S.EE-H....--------.............HHHHHHHHHHH..HHHHTTTT-.T...TEE-..SSST.TS-H...HHHHHHHHTTSSSSSH.................................................---HHHHHHHHHHHHHHHHHHHH.............................................TT-HHHHHHHHH.HHT-SSS--.--------.............-----..---------STTHHHHHHHHH.TTCCTHHHHCCT-..HHHHHHHHHHHHHHHHHHHTTSHHHHHHHHHHHTTX-XXX.................................................
F1QKQ7_DANRE/29-224              ....................vvqs-----.WIIDYY......................FATLCRLFRE...--....-----------................RSSVEFRKE.LKLFEGLVDEL.....E.SHSS....--------.............----QRTVCCF..LARVMDGEN.L...DVRY..DHVA.rITP...LMSAVPVWESLKDFSD.................................................--PTLHGKIQTLLMVQSVSVCVK.............................................KGYDKLAKETLQ.WLEEQTDVP.--------.............-----..---------EKLQRKLATIVN.KKDAYDQILMNFS..FDKLMETIDTFLEAFNQqyasvFLLEAASKVVQARH-ers.................................................
H0H202_9SACH/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLIF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtagnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLVKKQELLD.LIFPSNLAD.ILVQRRTGds........gdvALLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
F2TEN4_AJEDA/186-424             ........................MIQSL.PILDNL......................STQILTLLAQ...SSy..qDLTSIVSEPTS................ESGQAYSTM.RSLFDHTKNVY.....T.SKGS....FLSPRELD.............LTEPNQV--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQYFLEIFVPEGN.................................................RLLKVQGALFLELKTQAYIAAMS.............................................-SGKRSRTELLY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRAYSRRDILLNEVN.NPEAAAALPEKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKSSK---grls................................................
H2U491_TAKRU/2-201               ....................lvtg-----.WTLDFM......................FISLYRYFKE...--....-----------................GNLDKFNEV.LATFEGISQSP.....-.SVKG....--------.............EQSKKLLICAF..LARIMHGKQ.L...DVQF..EDEA.kVMP...LMSAAKVWSELRTTVV.................................................-DESVYKTINNLLFVQIVAVCLE.............................................KSKRSAASSAL-.RWFENNLEC.--------.............-----..--------PKNVKARLLAIVT.KNELQHPILKSFS..YSRLLRTIESYLDEYLErnpsdYLLKMATEMAQSS--qhme................................................
H2U492_TAKRU/1-195               ........................-----.WTLDFM......................FISLYRYFKE...--....-----------................GNLDKFNEV.LATFEGISQSP.....-.SVKG....--------.............EQSKKLLICAF..LARIMHGKQ.L...DVQF..EDEA.kVMP...LMSAAKVWSELRTTVV.................................................-DESVYKTINNLLFVQIVAVCLE.............................................KSKRSAASSAL-.RWFENNLEC.--------.............-----..--------PKNVKARLLAIVT.KNELQHPILKSFS..YSRLLRTIESYLDEYLErnpsdYLLKMATEMAQS---dgsh................................................
F8MNL0_NEUT8/269-507             ...................mirsm---SL.PVLGNL......................AVQILLRLSQ...QPr..nETLSLLSETDA................EFRKHYDLL.TESFKLARKGF.....-.SDSP....VLLPDELE.............INDSEDR--ET..VRVANLATT.A...ISVF..GAND..VAC...KDLDDSFFSIFVPEDG.................................................EFKDTLADLLLSLKTQAFLDSLD............................................eQATPQQVTEQLD.KFFPDNFED.WLKQRNLD.............VVTDT..DADQLAVKIKDRRELLSTLAN.SEQPKKS---KYS..PDTFPETLCVFLQSHIG.....VVVEYAEEYGVKIP-ise.................................................
E9D299_COCPS/178-416             ......................kt--ESL.PILDNL......................ATQILSLLAR...SSy..kDITSIVSEPNS................ENGHAYSSM.RSLFDHAKKVY.....S.TNGP....FLSATQLG.............FTKPGQI--DI..IRKANMASF.V...SSIF..GTQG..IGF...SELHDHFLEIFVPEGS.................................................RLLKGQGALFLELKTQAFIASMN.............................................-NSEQGRREILR.NLFPDDLGL.KLLARRPG............nKQLAP..SETDFVKRAWSRRDILLAEID.NPESVRTLPERYR..WEDFLRDLSSYVSKHYD.....STTTQCKKA------skgpsve.............................................
B8NH48_ASPFN/140-400             .......................k-IQSL.PILDNLvsiileqrfffawikyvltfiqSTQILSLLAK...STy..qDITSFVSEPDS................ENGQAYATM.RSLFDHTKKVY.....S.TKKS....FLSATELE.............LTESSQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERSRTELLY.DLFPDDLEQ.RLLERRPG............tRQLAP..SETDFVNRAKSRRDILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYVTKNFD.....TISNQQSKKITK---grqp................................................
G4NHA0_MAGO7/375-615             ...................vrsmg----L.HFLGSL......................AVQVLLALSE...RPr..vETVNAIRSSDS................ETGKAYKSL.SAAFKAARRMF.....S.ETSS....ILQADELK.............IEEPGDF--ET..IQMANLATI.C...STVF..ESDT..ASL...LEAHNGFLRTFLPELS.................................................PLTDNLTNLFLSLKTQAFLRSCP............................................eTADDARMRELLG.IYFPADAEA.PLKQLHPD.............SPLTQ..TEKVFMSMSTKRGERLGNEVR.DTMKRKLLAIEYP..WDGLLDDLNKYLRDNLD.....NVLTYAESQGIE---ipad................................................
Q7TSK8_MOUSE/61-258              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RDSAEAIIHGL.....H.RLTA....--------.............YQLKTVYICQF..LTRVASGKA.L...DAQF..EVDE.rITP...LESALMIWNSIEKEHD.................................................---KLHDEIKNLIKIQAVAVCME.............................................IGSFKEAEEVFE.RIFGDPEFY.--------.............-----..---------TPLERKLLKIIS.QKDVFHSLFQHFS..YNCMMEKIQSYVGDVLNeksssFLMKAATKVVENEK-art.................................................
F7A2U5_MONDO/3-200               .....................vag-----.WVMDYL......................CMNVCHAFCH...--....-----------................DMAEEFSQG.IVAMEAAVCGV.....H.NRPL....--------.............LQLKTVHICQF..LKRITRARC.L...DVRF..DGNT.vNTP...LESAMVMWNRMGYCKD.................................................---PRFDDIHDLLRIQAVAICLE.............................................KRGFREAEVIFR.RVFGANDTN.--------.............-----..---------RPLKKILFRVVS.KKDPNHTFFHYFS..FDSLIKKVKAFVRHVISekatsFLIRKAMKIVKHN--pees................................................
B2ZU82_CHICK/25-175              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENNT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQAATKQVE.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------seggevrvlqnktlnvkeerennleakqrpaeelr.................
A5DKQ0_PICGU/258-530             .......................l-VNSL.PTLDNL......................ATQILRMVAV...GPy..qKVVELASNPDS................AAGAAYRDL.TSLFEFTKRLY.....S.EEDP....FLSVEHIApgmwkegdqtpnvFKNREQSIEST..LRKVNLATF.L...VAAL..GTIE..VGF...FYLNEFFLNVFCPPHGldvensmsnmsae.......................nmnlqtgangdagRLLKPQAQLFLDLKTQAYISALE.............................................-VGDRSREDILD.EILP-DMEP.VLLAWRNS.............RMLTP..VEADFVARCRARKDTLL----.-RYDGHSLSEEYD..WFAFLRDLFDYVGKNVG.....YVVWGRRRRPASSN-sa..................................................
C7GJ82_YEAS2/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
Q8CH10_MUSSP/61-254              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RDSAEAIIHGL.....Q.RLTA....--------.............YQLKTVYICQF..LTRVASGKA.L...DAQF..EVDE.rITP...LESTLMIWNSIEKEHD.................................................-------EIKNLIKIQAVAVCME.............................................IGSFKEAEEVFE.RIFGDPEFY.--------.............-----..---------TSLERKLLKIIS.QKDVFHSLFQHFS..YNCMMEKIQSYVDYVLNeksssFLLKAATKVVENEK-art.................................................
G1TY99_RABIT/52-252              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKMKNDLLNIIR.EKNVAHPVIQNFS..YETFQQKMLRFLESHLDdtepyLLTMAKKALKSQS--aass................................................
Q5EB98_RAT/61-258                .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRCEDFRQT.RDSAEAIIHGL.....P.SLTA....--------.............YQLKTVYICQF..LTRVAAGKS.L...DAQF..EVDE.rITP...LESALMIWDSIEKEHD.................................................---KLHEEIQNLIKIQAVAVCME.............................................MGSFKEAEEVFE.RIFGDPEFY.--------.............-----..---------TPLERKLLKIIS.QKDVFHVLFQRFS..YNLMMEKIQSYVECVLNeksstFLMKAATKVVENEK-art.................................................
A3LVU7_PICST/169-447             .......................l-VNTL.PTLDNL......................ATQLLRVVAI...GPy..qKIIDLASNPDT................PAGATYRDL.TSLFEFTKRLY.....S.EEDP....FLSVEHIApgmwkegektpsmFRSREQSIEST..LRKVNLATF.L...AATL..GTIE..VGF...FYLNESFLDVFCPYNNldpenslsnmgrnsm...................slqsgvnttigdtisKLLKPQAVLYLDLKTQAYISAIE.............................................-AGERSREEILE.DILPHNLGD.IILARRGV.............KNLSP..TEMDFIERCKARKKTLL----.NHTGEKSLSEEYE..WFNFLRDLFEYVSKNMG.....LLIWGKKGRTPRSK-kd..................................................
Q6CE73_YARLI/147-379             .......................l-IDSL.PVLDNL......................AMQILNTVGR...QPy..qTTLTMVTEPDS................DLGQSFSIL.MSLFDQTKRLY.....S.QSEP....FISGISLG.............IRNREQK--GI..VQKANMATF.C...AAVF..GFAE..VGF...YHLHEFFLDSFVPDNM.................................................RLLKSHGALFLELKTQAYISAMS.............................................-QNEKSKTEILN.DLFPMDLDR.MLINRRNS.............KSLAP..SEVDFVSRCRSRRERLF----.NANSTAELSDTYS..WLSFLKEVVEHVSKV--.....YLATLVSKKASTQ--gpss................................................
H3BR06_HUMAN/2-173               ........sslpallvrplgkeht-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-VSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
Q5F3M6_CHICK/25-224              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
F7EB98_MACMU/72-269              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
F1RWI3_PIG/70-267                .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSGDFHRT.RDSAEALIHGL.....P.SLTA....--------.............YQLRTVYICQF..LTRIAAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPDSH.--------.............-----..---------MPFKRKLLIIIS.QKDTFHPFFQHFS..YNHMMEKIKSYVNCVLNeksstFLMKAATKVVESKR-art.................................................
F1MMS4_BOVIN/94-293              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTSLPKAL------ksessas.............................................
F1Q8U5_DANRE/14-210              .......................v-NR--.WSFDFY......................AFQAFSAFRN...--....-----------................GDYTAFTHF.INIIESVVVRP.....V.DGHP....--------.............DMIPQLRLMQF..LSRINNGDK.L...DLTF..EEPK..-TP...LESALDVLESICRDMS.................................................VPHPEQQLIRHAISEMLVMVCIR.............................................SGEFEKAEEMLK.HFSSSSDSA.--------.............-----..----------GKKKLLLNLIR.CRRSSHSVLQLSS..YSHFKQDMLQFVERLFSvpepfLLQMLRRSGWPSQ--rpe.................................................
Q4FZZ9_DANRE/14-210              .......................v-NR--.WSFDFY......................AFQAFSAFRN...--....-----------................GDYTAFTHF.INIIESVVVRP.....V.DGHT....--------.............DMIPKLRLMQF..LSRINNGDK.L...DLTF..EEPK..-TP...LESALDVLESICRDMS.................................................VPHTEQQLIRHAISEMLVMVCIR.............................................SGEFEKAEEMLK.HFSSSSDSA.--------.............-----..----------GKKKLLLNLIR.CRRSSHTVLQLSS..YSHFKQDMLQFVERLFSvpepfLLQMLRRSGWPSQ--rpe.................................................
F2QLG1_PICP7/92-384              ........................LINTI.PTLDNL......................ATQILRIIAQ...GPy..qKILDIVANQDS...............tLAGISYKNL.IELFEMTKRIY.....S.TEDP....FLNVEHLTfgiwkygceppsfLKGKEDSVEST..LRKVNLATF.L...NATL..GTND..AGF...YHLNESFLDVFCPSQSldpsntmtnltgnsis................gyqegetqrtsanfvpgKLLKSQAGLYLDLKTQAYISALE.............................................-INERPKDEILE.DLFPDNMDE.ILLKRKNPdmelq..lpinksTAFTP..AESDFISRANIRKQRLQ----.ESDNDSKLAETYE..WLVFLKELFDYVSKNVG.....ILIWGRRGR------lgnlsq..............................................
C5FJK7_ARTOC/167-405             ......................ks--QSL.PILDNL......................STQILCFVAR...TSf..qDLTTLVSDPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TTQP....FLSASNLG.............FTDPSQV--EI..IRKANLASF.V...FSLF..GTQE..IGF...SELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPARPKADILY.ELFPDNLGL.KLLARRPG............tRHPAP..SETDFVKRAWSRRDILLGEIK.NPDSVNTLPEKYL..WQDFLRDISLYVSKNID.....SLTTQQSKRPNKT--rsp.................................................
B0Y0Z4_ASPFC/193-431             .......................k-IQSL.PILDNL......................STQILSLLAK...STy..qDITSFVAEPES................ENGQAYATM.RSLFDHTKKVY.....S.SKES....FLSPTELG.............LTEPSQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...AELNEHFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERTRTELLY.DLFPDDLEQ.RLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....AICHQQTKKSNK---grqp................................................
C0NNV2_AJECG/165-403             .......................m-TKSL.PILDNL......................SSQILTLLAQ...SSy..qDLTSIVSEPNS................ECGQAYSTM.RSLFNHTKNVY.....S.SKGS....FLSPRELN.............LTEPSQM--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQHFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SGKRSRTEILY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRVFSRRDILLNEVN.NPEAASALPQKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKPSK---grps................................................
B7ZR57_XENLA/16-215              .....................vat--N--.WMCDFM......................FASMCFYFRE...--....-----------................DRTEDFQRS.THMLEWLLEGS.....Q.KIDA....--------.............-HRKTIPIAQF..LMRVAEGKN.L...DSQF..DTDE.sLTP...LETALMAFNQIEEEED.................................................-LKHLHEEIELLLKVQAVVTCME.............................................KGRFKLSAEILD.RLFKESGSN.--------.............-----..---------KYLRMKLTMLIE.KKDPYHEFLQNFT..YAQMMKKIKSYIALKMKerpsvFLLKAAAKVVEATA-kee.................................................
G4UU77_NEUT9/269-510             ...................mirsm---SL.PVLGNL......................AVQILLRLSQ...QPr..nETLSLLSETDA................EFRKHYDLL.TESFKLARKGF.....-.SDSP....VLLPDELE.............INDSEDR--ET..VRVANLATT.A...ISVF..GAND..VAC...KDLDDSFFSIFVPEDG.................................................EFKDTLADLLLSLKTQAFLDSLD............................................eQATPQQVTEQLD.KFFPDNFED.WLKQRNLD.............VVTDT..DADQLAVKIKDRRELLSTLAN.SEQPKKSLESKYS..PDTFPETLCVFLQSHIG.....VVVEYAEEYGVKIP-ise.................................................
TERF2_MOUSE/97-297               .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKLRTDLLNIIR.EKNLAHPVIQNFS..YEVFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aass................................................
Q71E47_XENLA/16-215              .....................vat--N--.WMCDFM......................FASMCFYFRE...--....-----------................DRTEDFQRS.THMLEWLLEGS.....Q.KLDA....--------.............-HRKTIPIAQF..LMRVAEGKN.L...DSQF..DTDE.sLTP...LETALMAFNQIEEEED.................................................-LKHLHEEIELLLKVQAVVTCME.............................................KGRFKLSAEILD.RLFKESGSN.--------.............-----..---------KYLRMKLTMLIE.KKDPYHEFLQNFT..YAQMMKKIKSYIALKMKerpsvFLLKAAAKVVEATA-kee.................................................
E5RFJ5_HUMAN/104-168             .....................sae-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RI-------.--------.............-----..---------------------.-------------..-----------------.....---------------....................................................
G3SU07_LOXAF/71-268              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSEDFHQT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTVYICQF..LTRIAAGKT.L...DAQF..ESDE.rITP...LESALIIWDSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................SGNFKEAEEVFE.RIFDDPNSY.--------.............-----..---------TPLKRKLLTIIS.QKDAFHSIFQHFS..YSHMMEKIKRYVNYVLKeksstFLMKAATKVVESKR-art.................................................
C0SB27_PARBP/147-384             .......................k-TQSL.PILDNL......................STQILTLLAQ...SSy..qDLTSMVSEPNS................DSGQAYSTM.RSLFDHTKNVY.....S.SKGS....FLSPRELD.............LTEPTQV--DI..IRKANMASF.V...SSIF..DSQE..IGF...SELDANFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SAKRSKTELLH.ELFPDDLEQ.RLLSRRPG............tKQLAP..SETDFVNRAYSRRDILLNEVN.NPAAAAKLPEKYR..WEDFLRDLSSYVSKNFD.....AISHQQTKKPSK---grp.................................................
B2DFX9_BOVIN/4-67                ...................ehtvs-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............---RLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVI-----------------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------essrklv.............................................
C6HM22_AJECH/180-418             .......................m-TKSL.PILDNL......................SSQILTLLAQ...SSy..qDLTSIVSEPNS................ECGQAYSTM.RSLFNHTKNVY.....S.SKGS....FLSPRELD.............LTEPSQM--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQHFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SGKRSRTEILY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRVFSRRDILLNEVN.NPEAASALPQKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKPSK---grps................................................
F1S2L2_PIG/52-251                .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYEDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSE---ssts................................................
B2B1Z5_PODAN/303-509             ....................mrsm---SL.LNMGSF......................AVQILIRLSQ...NTk..aDTDALLAQTES................EFYKAYGML.WNVFESTRKMY.....-.SDSH....LLSVDELE.............ITDSEDR--ET..IRMSNLASV.A...GMVF..GSGD..VTL...KDVHDSFFSVFIPEDG.................................................EYKDSLTELLVSLKTRLFLDALN.............................................HQPPQPALGVLD.TLFPARFDE.VLKNRSGD.............LALNP..DEERLVGQVRERRELLVQSAA.DES----------..-----------------.....---------------ikstcsspfgf.........................................
Q539Y8_MUNRE/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLKTIYVCQF..LTRIAAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVSCVLNeksstFLMKAAAKVVETKR-art.................................................
Q3MHY0_BOVIN/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYVCQF..LTRIEAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNCVLNeksstFLMKAAAKVVETKR-art.................................................
Q6BTS1_DEBHA/349-627             ........................LINTL.PTLDNL......................ASQLLRIVAL...GPy..qKILDLAAHPDT................PAGATFRDL.TSLFEFTKRLY.....S.EEDP....FLSVEHLApgmwkegdktpsiFRNREQSIEST..LRKVNLATF.L...GATL..GTIE..VGF...FYLNESFLDIFCPANNldptntlsnmsphnm...................slqsgvntiigdkigKLLKPQTVLYLDLKTQAYISAIE.............................................-AGGRSREDILE.DILPHNLED.ILLERRKT.............KILTP..TEFDFIDRCKSRKEILL----.NYPSDKVLSEEYD..WLSFLKELFEYSAKNMG.....FLIWGKKGRATKEK-nt..................................................
H0VF28_CAVPO/71-268              .....................aag-----.WMLDYF......................CLSLCRAFRD...--....-----------................GRSEDFHRI.RDSAEAVIHGL.....P.SLTS....--------.............DQLRTVYICQF..LTRIAAGKS.L..eDAQF..ESDE.rITP...LESALMIWASVEKQHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................HGSFKEAEEVFE.RIFGDPYCH.--------.............-----..---------TTLERKLIKIIS.EKDPYHSFFQHFS..YNRMMEKVRSFVSWVLReksstFLIKAAVKVVESE--ntr.................................................
A7TKR0_VANPO/36-333              .......................t-LSSL.CILDDI......................STLILRFILLnklAP....HAISILINGDTkalsglvngkenltilHDIEIFQNL.LHNFMNLKKIY.....-.NNKL....IITVFDVAyglwvpnssppyiLKEFKFYITNT..VKKINLLTY.L...LISL..GCCE.dYGF...DILDEIFFDIFCPHSIfnkykirklqpeldtt.................ttfedfnnkkdldiarKFLKTHGVLYLELKTQHFITILEn..........................................snEAIDFIKEDILN.QIFPPDLIN.I-----ND.............KNMIP..SEIEFIKRCNHRKESLL----.KYDSLENLQKDYE..WKDYIKELVNFCDKNIG.....MIILGRPHRDINP--lfdy................................................
Q3V252_MOUSE/61-168              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RDSAEAIIHGL.....H.RLTA....--------.............YQLKTVYICQF..LTRVASGKA.L...DAQF..EVDE.rITP...LESALMIWNSIEKEHD.................................................---KLHDEIKNLIKIQ-------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------pl..................................................
F7E8S9_XENTR/16-213              .....................vat--N--.WMCDFM......................FASICFYFRE...--....-----------................DRTEEFQRS.ANVLEWLLEGS.....R.KIDA....--------.............-HRKTIPIAQF..LMRVSEGKN.L...DSQF..DTDE.sLTP...LETALMTFNQIEEEED.................................................-LKNLHEEIELVLKVQAVVICME.............................................KGKFKLSSEILD.RLFQESGSN.--------.............-----..---------TYVRMKLAMLIE.KKDPYHEFLQNFT..YAQMMKKIKTYITLKMKarppvFLLEAAAKVVE----avak................................................
Q539Y7_MUNRE/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLKTIYVCQF..LTRIAAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVSCVLNeksstFLMKAAAKVVETKR-art.................................................
F7F093_ORNAN/2-176               ...........lsaiihglsklss-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............HQRRTIYICQF..LTRIAEGKT.L..eDAQF..ESDE.rITP...LESALSIWSSVGKDQV.................................................LSDKLSEEIRDLIKIQAVAVCLE.............................................KGNIKEAEEVLE.RVFGESNPN.--------.............-----..-----SPDPDSLKLKLLTIIS.RKDPYHPFLQHFS..YPCMMEKIKSFVDLIIHekasgFLVREATKVVDNQ--raqt................................................
H3BTA7_HUMAN/1-132               ......................me-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...----..--AE..LTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTIG----------fmakkalksesaa.......................................
G1SIB8_RABIT/70-268              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEAFHRT.RDSAEAIIHGL.....S.NLTA....--------.............YQLKTIYICQF..LTRIAAGKS.L..eDAQF..ENDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPKSY.--------.............-----..---------TSLERKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNCVLNekssaFLMKAAAKVVESKR-art.................................................
G9KSX6_MUSPF/69-267              ....................iaag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIASGKA.L...DAQF..ETDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLVKIQAIAVCME.............................................NGNFKEAEEVFE.RIFDDPNSY.--------.............-----..---------EPLKRKLHKIIS.QRDTFHSIFQHFS..YNNMMEKIKSYVNSVINekssaFLMKAAAKVVESRR-art.................................................
Q6CRS7_KLULA/27-307              .......................l-LKTL.PLLDGV......................TVQLLRFLSA...NSl..rTILAIISDASPka............fpLEQDLYHSL.LALFIKLVSLY.....N.TKPQ....LLRVSHIFpgvwhdhhpspsfIQTHERYILLV..LRKVNICLF.L...LTLL..KELP..FGI...SFLADNFIEVFCFNVDsskvedlit...............................anrsrivygRLLKPQTVLYLDLMTQYYISALVs...........................................sSTPHTSKSPLLD.QVFPDTILD.DIKDKTIKya........gkyMQLQIqcTETDFKERCKRRKTAIL----.ECPDLQKLMKKYD..WEECCKEVFSYGIKRAD.....VLLYGRRGKGLSS--vps.................................................
E4UMR5_ARTGP/173-412             .......................k-AQSL.PILDNL......................STQILCFIAR...TSf..qDLTSLVSEPQS................ENSQSYSTL.RSLFDHTKKVY.....T.TSKP....FLSASELG.............FTDASQV--EV..VRKANLASF.V...FSLF..GSQE..IGF...SELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPARPKVEILY.ELFPDHLGV.NLLARRPG............tRHPAP..SETDFVKRAHSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....SLTTQTKRPNKTR--spts................................................
B8QB40_XENLA/16-215              .....................vat--N--.WMCDFM......................FASMCFYFRE...--....-----------................DRTEDFQRS.THMLEWLLEGS.....Q.KIDA....--------.............-HRKTIPIAQF..LMRVAEGKN.L...DSQF..DTDE.sLTP...LETALMAFNQIEEEED.................................................-LKHLHEEIELLLKVQAVVTCME.............................................KGRFKLSAEILD.RLFKESGSN.--------.............-----..---------KYLRMKLTMLIE.KKDPYHEFLQNFT..YAQMMKKIKSYIALKMKerpsvFLLKAAAKVVEATA-kee.................................................
G3BC67_CANTC/178-456             .......................l-VNTL.PSLDNL......................ATQILRIFTV...GPy..qKIIDLVSNVDT................AAGASFRDL.TSLFEFTKKLY.....S.DEDP....FLAVSHVApgtwnhsestpapFKNREQSIEST..LRKVNLATF.L...LATL..GVIE..VGF...FYLNESFLGIFCPLNNldphnslsnhlentg...................stvggstpgagdrigKLLKSQAILYLDLKTQAYISAIE.............................................-AGERSRVEVLD.DILPDNLDA.ILMEKRST.............KILSP..TESDFIDRCKSRRTILL----.NYPDNSTLSEEYD..WFSFLRSLFEFVGKNML.....FLIWGNKKIT-----kprpdd..............................................
D3YZ08_MOUSE/97-297              .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKLRTDLLNIIR.EKNLAHPVIQNFS..YEVFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aass................................................
F6VIR4_MOUSE/1-178               ....................xeal-----.------......................-----RAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKLRTDLLNIIR.EKNLAHPVIQNFS..YEVFQQKMLRFLESHLDdt.epY--------------lltv................................................
F6XW10_MONDO/17-218              .................adslacg-----.WMLDFF......................CLNLCQAFCE...--....-----------................DDIEEFKRN.RNIAEAIIHGL.....S.RLTA....--------.............HHLRTIYVCQF..LTRIVEGKT.L...DAQF..ESDA.rLTP...LESALIIWNKIRKEKE.................................................---ILHDQIHDLLEIQAVAVCME.............................................KASHKEAEGVFE.RIFGDTEDN.--------.............-----..---------NPLKMKLLMVIN.KKDPNHVFFQRFT..YKCMIDRIKIYANQVLTeksssFLMKAALKVVESKK-dee.................................................
B6Q5I5_PENMQ/156-394             .......................k-IQSL.PILDNL......................STQILSLLAK...SSy..qDITSFVSEPDS................ENGQAYATM.RSLFDHTKRVY.....T.TKQA....FLSPTDLD.............LTEPSQV--DI..IRKANLASY.V...SSIF..GSQE..ISF...AELNDHFIDVFVPEGR.................................................GLLKVQGALFLELKTQAFIASLN.............................................-NEERTRTEILF.ELFPDDLEQ.RLLSKRMG............tRQLAP..SEADFVKRARSRRDIIFADIN.NEEAMKALPDKYH..WEDFLRDLSSYISKNFE.....AINSQQSRKLV----kgrqs...............................................
H2RA24_PANTR/52-252              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKTALKSES--aass................................................
E7QLB4_YEASZ/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
F6KWE7_RAT/52-252                .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRRLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKVRTDLLNIIR.EKNLAHPVIQNFS..YEIFQQKMLRFLESHLDdtepyLLTMAKKALRSE---saass...............................................
B6HIX8_PENCW/182-420             .......................k-IQSL.PILDNL......................STQILSFLSK...NSy..qDLTAMVSEPDS................ENGQAYATM.RSLFDHTKRVY.....T.VKHS....FLQPTDLE.............ITDASQI--DV..IRKANLASF.V...SSIF..GSQE..IGF...ADLNDHFLDVFVPEGG.................................................RLLKVQGALYLELKTQAFIAAMH.............................................-NKSLTRTQLLY.NLFPDDMEQ.RLLARRPG............tRQLAP..SETDFVNRLTSRRDILLNEIN.NEEALNALPDKYH..WEDFLRDLSSYISKNFD.....AINTQQGKKPVK---grqp................................................
G8Y623_PICSO/328-606             ........................LINTL.PVLDNL......................ATQLLRVISD...SSy..qKVLDLAARADT................PAGAAYRDL.TSLFEFTKKLY.....S.EEDP....FLNVEHIApgmwkegdktpsiFRAREQSIESA..LRKVNLATF.L...GATL..GTIE..VGF...FYLNESFLDIFCPANSlnpsnslsnmspsns...................gvqsgfntavgdrcgRLFKPQASLYLNLKTQAYISAVE.............................................-ADERSREEILN.DILPDNLTE.MLSAKRRV.............KTLSP..SELEFIEQCKIRKDLLL----.SYPPTKDLSEEFE..WISFLKELIEYAAKNMS.....FLVWGRKGRTTTR--dkg.................................................
H1VU70_COLHI/113-352             ...................rritt-----.SCLSNF......................AMQLLVIMSQ...HVy..dDVYRQLQDKDT................DIYKSYSTL.KTLFCKTRSMY.....S.TTDL....ILDPAVLD.............LTAPDNL--TD..IQVANLASF.C...CELFtfDGNH.eLASqqlLALRDHFFSIFLSGGE.................................................SISHEISELFVAVKTQLVIESVT............................................tADQSAPVDQLIA.EAFFSDLED.KLRARHDG.............TELTP..EERALVTTVEERKSGLIAYAS.GLPDTVLLKIGYP..EEDLFRLLNAHLRQKL-.....---------------qsfsglasrhg.........................................
TERF2_HUMAN/52-252               .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
#=GR TERF2_HUMAN/52-252    SS    .......................H-HH--.HHHHHH......................HHHHHHHHHT...--....-----------................T-HHHHHHH.HHHHHHHTTS-.....-.STTH....--------.............HHHHHHHHHHH..HHHHHTTT-.T...TEE-..SSST.TS-H...HHHHHHHHHHHHHHTT.................................................--HHHHHHHHHHHHHHHHHHHHH.............................................TT-HHHHHHHHH.HHSSS-STG.--------.............-----..---------HHHHHHHHHHHH.HTTTTSHHHHT--..HHHHHHHHHHHHHTTS-----HHHHHHHHHTTTXX--XXXX................................................
G7NQM2_MACMU/4-179               ...................rptms-----.------......................----------...--....-----------................---------.--SFPALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
G1NG40_MELGA/36-235              .....................aad-----.WVLEFS......................CCCLCRHFVE...--....-----------................ECGAEFGRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECQF..ENDT.rISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YNLLLSKVKSYVELFLKengtnFLLQAATKQVESKG-ge..................................................
Q4WVB2_ASPFU/193-431             .......................k-IQSL.PILDNL......................STQILSLLAK...STy..qDITSFVAEPES................ENGQAYATM.RSLFDHTKKVY.....S.SKES....FLSPTELG.............LTEPSQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...AELNEHFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERTRTELLY.DLFPDDLEQ.RLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....AICHQQTKKSNK---grqp................................................
H0ZCM7_TAEGU/4-202               .....................vng-----.WVLQFY......................FHRAIEAYRS...--....-----------................GRNRDFRQF.RDIMQALLVRP.....L.DREP....--------.............DVTQMLRIMQL..LSRVEEGEN.L...DCTF..DKEL.eLTP...LESAMLVLDFIREEFS.................................................VADRTMETVQKMVKEAAVVVCIR.............................................NKEFEKASDIVK.KHFGKEPRN.--------.............-----..---------QKKRNEWLAVIR.EKNPSHPKVKNFS..YEDFQQSIFGFLKGYMDdsepaLLTLLKKTL------dsehtg..............................................
I1RCX3_GIBZE/145-371             ....................asrh-----.-ALGNM......................ALSVLLLFSQ...SF...dDSIKPIQDADS................QHAKSFHDL.QTSFAQIKQIY.....-.SSGP....ILSADEPD.............LQDHESR--TI..LDLANLAQF.C...IWLL..QTTP..-SY...SEAHQHFHAIFRGQVS.................................................DLGSDALDLYLSLKTQVAIDALV............................................sKTTEQSSEQVLE.EALINGMED.KLRGLHNG.............FDLTP..ADSEFITSVRSRKTSLE--GE.TSTESAVLREKYK..VDDLLRQVSTCVKTRLA.....LM-------------sdlgsrlg............................................
G3PV88_GASAC/14-198              .......................v-NR--.WIVDYY......................SHLALDFFKN...--....-----------................KKYAEFCGI.RDVLQSVLVRP.....L.ESSD....--------.............VTQTKIRVLQF..LSRINDGEH.L...DLTF..ESDE.sLTP...LESALVVLETIIQECK................................................tAMPELFEGVCTSIKEMIVGLLIK.............................................NKEFDHANEVLK.KHFPKSMVG.--------.............-----..-----------KKAIFMGLVK.KKSNVHAVIEQID..FQRFKDEMFAFCQRL--.....---------------cplnlpfly...........................................
G7MZJ2_MACMU/72-271              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQXXXxxXXXMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
G3SHY3_GORGO/72-269              .....................aag-----.WMLDFL......................CLSLCRTFRG...--....-----------................GHSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
B3LKU7_YEAS1/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
A5DUJ2_LODEL/258-546             ........................LINTL.PTLDNL......................ATQLLRVVVT...SSy..kKIIDLASNPET................PQGATYRDL.TSLFEFTKRLY.....S.EEDP....FLTVEHLApgmwhvgevtpqiFKNKEQSIEST..LRKVNLATF.I...AATL..GTME..IGF...FYLNEFFLDIFCPANDldiknslldtnyldttvs............slatsiqsgsgttigskigKLLKPQALLYLDLKTQAYISAIE.............................................-AGERSRAEILE.DILPDNIDE.ILMKRRNI.............SLLLP..TEIDFVERCRSRKTFLL--SH.DEDPQQPLSENFK..WFSFLKDLLDYVSRNMG.....YLVWGKSGKPSRDR-gee.................................................
E9PSR8_RAT/91-291                .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRRLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKVRTDLLNIIR.EKNLAHPVIQNFS..YEIFQQKMLRFLESHLDdtepyLLTMAKKALRSE---saass...............................................
G9NAU5_HYPVG/141-364             ................nthalgnl-----.------......................----------...QPi..dDMSKLAGDADS................GYGRSYGRL.KRSFDATWQLF.....-.SDNQ....VLSADELE.............IQEAEAR--TL..LELANIAKF.G...TWLV..EGGL..DSF...TAADGHFAAVFRCQLS.................................................DLSAGLSQLYLGIKTHKTIESLLi...........................................rNGDGPSIEEVVQ.TIMLEGLNE.--PTDATS.............EPISA..SQQELLAAVKSRRDVLVDEVK.IKEPA-ALREKFP..TGDVLKSFSAHVRTTLA.....SMTEI----------geklgvsalls.........................................
G3YE64_ASPNA/180-418             .......................k-IQSL.PILDNL......................STQILSLLAK...SSy..qEITSFVSEPET................ESGQAYATM.RSLFDHTKKVY.....S.SKKS....FLSPTELE.............LTESSQI--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NSERTRTELLY.DLFPDELEQ.QLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLSDVN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....TISNQQTKKTAK---grqp................................................
E3QWE2_COLGM/141-384             ...................rrttt-----.SCLSNF......................AMQLLVIMSQ...HVy..dDIYRQLQDKDT................ELSKSYSTL.KTIFRQTRSIY.....S.TTDL....ILDPAVLD.............LTAPDNL--TD..IQVANLASF.C...CELFafDGHH.dLASqqlLALKDKFFPVFLSGDE.................................................SVSHDISELFVAVKTQLVIESVT............................................tADQSAPVDQLIA.EAFSSDLED.KLRARHDG.............TELTP..EEKAMVTAVEERKAGLIAYAS.GLPDTVLLKIGYP..EEDLFRLLNTYLRQKLH.....SLSGLAS--------rhgielp.............................................
G3I013_CRIGR/28-112              ......vnhvffpallvrplgkeh-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKE--------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------akl.................................................
F6YH07_MONDO/22-222              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................GRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TISRLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLETIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLGIIR.ERNITHPVIQNFS..YEIFQQKMLRFLESHMDdaepyLLTMAKRALKSESA-sts.................................................
C1GUR5_PARBA/179-417             .......................k-TQSL.PILDNL......................STQILTLLAQ...SSy..qDLTSIVSEPNS................DSGQAYSTM.RSLFDHTKNVY.....S.SKGS....FLSPRELD.............LTEPTQV--DI..IRKANMASF.V...SSIF..DSQE..IGF...SELDANFLEIFVPEGS.................................................RLLKVQGALYLELKTQAYIAAMN.............................................-SAKRSKTELLR.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVNRAYSRRDILLNEID.NPAAATKLPEKYR..WDGFLRDLSSYVSKNFD.....AISHQHTKKPSK---grps................................................
G9KSX7_MUSPF/2-167               ............llvrplgkehtv-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............--SRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSE---taas................................................
C5DXM7_ZYGRC/26-304              .......................n-ISSL.CLLDNV......................ATQMLRLLLL...NSt.spQVIEVISDPTAyl............ssGETEMFQTL.LKLFTHIRMIY.....D.SKTP....LLTVHDVVpglwfpncpapliLRGHEAYIVTA..IRKSNLLTF.L...LTIL..NCFN..YGF...ELLQESFLDVFCPNTIftgnt......................................tidqngKFLKSQAILYLELKTQAFISALKsfe......................................ngsdRIPTAKQQEFLD.IFFSNNLSD.QLVLRRRGnrh......niteEIMTP..SQREFVERCERRRENLL----.NYTSFKNLIQDYD..WNHFVKELLDYCNKNLG.....LIIWGHKGKGKSP--ly..................................................
G3QP07_GORGO/52-205              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.QMAKK---.............-----..---------------------.-------------..-----------------.....---------------alksesaasstg........................................
F1NEJ5_CHICK/25-224              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAISNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
H2RKB1_TAKRU/5-201               .......................v-NR--.WLLDYY......................FSLGLQFFQR...--....-----------................DQREDFLDI.VHVFEGILKRP.....Y.EVTS....--------.............HTRIQIRLVQL..LDQVNDGRS.S...AASF..EQNN..--C...LETVLSLLEALNKDFI.................................................IQQEDYNSVHASLRDLIVVILVK.............................................DGMFKKAEEMIK.KHFPRPMVGnYL------.............-----..--------VAKRKAIFMGLIK.MKSKSHPVIDQID..FQHFMQEIVVFCQKICP.....---------------lrlpflckvfskqaaav...................................
H2U488_TAKRU/18-216              .................vsslvtg-----.WTLDFM......................FISLYRYFKE...--....-----------................GNLDKFNEV.LATFEGISQSP.....-.SVKG....--------.............EQSKKLLICAF..LARIMHGKQ.L...DVQF..EDEA.kVMP...LMSAAKVWSELRTTVV.................................................-DESVYKTINNLLFVQIVAVCLE.............................................KSKRSAASSAL-.RWFENNLEC.--------.............-----..--------PKNVKARLLAIVT.KNELQHPILKSFS..YSRLLRTIESYLDEYLErnpsdYLLKGVKR-------qrvfi...............................................
F7WAY8_SORMK/270-512             ...................mirsm---SL.PVLGNL......................AVQILLRLSQ...QTw..dETLSLLSEADA................EFRKHYDLL.TESFKLARRAF.....-.SDSP....VLLPDELE.............INDSEDR--ET..IRVANLATT.A...ISVF..GAHD..VAC...KDMDDSFFSIFVPEDG.................................................EFKDTLTDLFLSLKTRAFLDSLD............................................eQATHQQITEQLG.KFFPDNFED.WLKQRNLD.............VVTDT..DADQLAVKVKERRELLSTVANnNEQPKESLESKYP..PDTFLQALCTFLQSHIG.....VVVEYAEEYGVKIP-ise.................................................
G0VCC8_NAUCC/27-314              .......................t-ISSL.CLLDNI......................STQLLRLLIFnanSP....HAIAILTDNKAssp..........ysqGETDTFQTL.LKLFKQVRMIY.....N.SRYP....LLTVHDVApglwfpdsappslLRGHEAYIITA..IRKVNLLTF.I...LTAL..GSFH..YGF...ELLQSTFLDIFCPNTLynssnst...................................tmgepngKFLKSQAVLYLDLKTQAFISALKdye......................................ddsnVIPQGKKQELLN.LVFPANLPH.SLIKRRTGapedt...itnplGAMTP..SERDFVERCDRRKENLM----.QVTNFNDLIINYD..WNHFIKELLDYCNKNMG.....LIIWGRKGRGKSP--lfs.................................................
H2NER4_PONAB/56-252              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRTqRNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESDLMIWSSIEKEHD.................................................---KLHEEIQNLTKIQAIAVCMN.............................................--GNFKEAEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
G3VUW4_SARHA/17-212              .....................iag-----.WVMDYL......................CMNICHAFCD...--....-----------................DLLEEFNQN.ITAMEAVSCGV.....H.NRSL....--------.............LQLKTVHICQF..LKRICKGKC.I...DMRF..DGNT.vSTP...LESALAMWVRLGYSKD.................................................---VRFEDIYDLLRIQAVAICLE.............................................KKGFREAEAVFR.RVFGENDSN.--------.............-----..---------RPLKKILFRVVA.KKDPNHTFFSYFS..YDCLIRKVKAFVHHVINeksssFLIKKATKIVK----ntpv................................................
F6V5V7_CALJA/49-249              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
Q2LMV6_XENTR/15-154              ....................avat--N--.WMCDFM......................FASICFYFRE...--....-----------................DRTEEFQRS.ANVLEWLLEGS.....R.KIDA....--------.............-HRKTIPIAQF..LMRVSEGKN.L...DSQF..DTDE.sLTP...LETALMTFNQIEEEED.................................................-LKNLHEEIELVLKVQAVVICME.............................................KGKFKLSSEILD.RLFQESGSN.--------.............-----..---------------------.-------------..-----------------.....---------------tyv.................................................
A2RAV5_ASPNC/146-383             .......................k-IQSL.PILDNL......................STQILSLLAK...SSy..qEITSFVSEPET................ESGQAYATM.RSLFDHTKKVY.....S.SKKS....FLSPTELE.............LTESSQI--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NSERTRTELLY.DLFPDELEQ.QLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLSDVN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....TISNQQF--------pvstqppd............................................
Q2GV64_CHAGB/284-525             ...................vmrsm---SL.PVLGNI......................AVQILLRLSQ...QPr..tETESLLADSGS................EFRKAYDML.RDIFRPTRKAF.....-.SDSP....LLSPDELD.............ITDSEDR--ET..IRMSNLAAT.A...ASVF..GAHD..VAV...HDVHDAFFSIFIPEDG.................................................EYKSPLTDLLVSLKTRMLLDALN............................................kPEQSQPVSQLLD.ALFPVTFEE.SLKQRSGD.............LLLNP..DEEGLVARIRETREQLVKSAA.DESIKRSLEDQSS..SLKFTGILSTFLQSHLG.....VIVDYAEKYGVNIP-lne.................................................
D4DFY7_TRIVH/176-415             .......................k-AQSL.PILDNL......................STQILSFIAR...TSf..qDLTALVSEPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TNKP....FLSASELG.............LTEASQV--EV..IRKANLASF.V...FSLF..GTQE..IGF...AELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPARPNVEILY.ELFPDNLGL.SLLARRPG............tRHPAP..SETDFVKRASSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....SLTTQTKRLNKTR--spts................................................
H3A9N7_LATCH/37-250              .....................vvn--C--.WLLDFN......................YYVALKAFRA...--....-----------................GNYQAFNGL.RDFTQALLAQP.....L.RKSK....--------.............MNIKHIRVMQF..LSRINEGQLlL...DCCF..DVED.gLTP...LESALDVFDEMQDVFW.................................................-SEEVAETLRIAITEAAVIVCIK.............................................AKNYDRASKILK.TFGNKDPKI.-QKGKKKK.............KLLV-..---DFLHS-RKLKMPLI---Y.NTIQYR----RYQ..SHRYIKALTEYISR---.....---------------aepylhlvslqayaekdssnrsqilyel........................
Q6FJX7_CANGA/32-309              .......................t-LSTL.SLLNDV......................STQLLRFLISnahTP....NVIAVISNKENyi............stGESEMFHTL.VRIFKNIRDVY.....E.SRTP....LLNVNNVApglwllnmppptiLKGHEAYIIST..IRKANLVTF.I...LTVI..NCLP..YGF...DFLQKVYLDVFCPNTIltdqt......................................ngdqvsKFLKPQAIIYLDLKTHAYISSIRdhl......................................ganeQIPDAEKRILLD.TIFPDNIAM.RLVNRKIVap........nekKILTP..SEKEFVGRCERRKETLI----.KFTNYTDLLNSYD..WTFFVKELLEYCGKNMN.....LIVWGKKGRSKTA--lle.................................................
G7Q1I2_MACFA/9-184               ...................rptms-----.------......................----------...--....-----------................---------.--SFPALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
F7IQX6_CALJA/71-268              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRQT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTVYICQF..LTRIAAGKN.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIEVQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNS-.--------.............-----..--------CAPLKRKLLMIIS.QKDTYHSVFQHFS..YNHMMEKVKSYVNDVLSeksstFLMKAAAKVVESKR-art.................................................
E9ENU1_METAR/138-374             ....................tnvh-----.-ALGNL......................ALSLLLVLVQ...SPf..eDTIKLVRGSEA................QHEKTFRGL.KCSFEHVHEMY.....-.SPGP....VLSANELE.............FRDSDSQ--IF..IGLANLAQL.G...LWLV..DGTP..KAL...SKADENFLAMFQCQLS.................................................ELPPGMTELYLGIKTQRAIEFLV............................................eKEPEKPSEEVIG.EVLTHGLEH.TLKEQHGG.............GELTS..ADQNFVSSVQTRKETLQGEVK.EESEPAALREKHP..AEDLLRSFLEYTAGRLK.....SLTDIGNK-------lgitieis............................................
Q5BH27_EMENI/197-435             .......................k-IQSL.PILDNL......................STQILSLLAK...STy..qDITSFVSEPES................ENGQAYATM.RSLFDHTKKVY.....S.TKKS....FLSPTELE.............LTEPSQV--DI..IRKANLASF.V...SSIF..GTQE..ISF...SELNDNFLDVFVPEGG.................................................RLLKQQGALFLEMKTQAFIASMN.............................................-NTERTRTELLY.TLFPDNLEQ.QLLDRRPG............tRQLAP..SETDFVNRAHSRREILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....TINNQQSKKITK---grqp................................................
H2U490_TAKRU/2-201               ....................lvtg-----.WTLDFM......................FISLYRYFKE...--....-----------................GNLDKFNEV.LATFEGISQSP.....-.SVKG....--------.............EQSKKLLICAF..LARIMHGKQ.L...DVQF..EDEA.kVMP...LMSAAKVWSELRTTVV.................................................-DESVYKTINNLLFVQIVAVCLE.............................................KSKRSAASSAL-.RWFENNLEC.--------.............-----..--------PKNVKARLLAIVT.KNELQHPILKSFS..YSRLLRTIESYLDEYLErnpsdYLLKMATEMAQSS--qhme................................................
Q8X0L3_NEUCS/270-508             ...................mirsm---SL.PVLGNL......................AVQILLRLSQ...QPr..nETLSLLSETDA................EFRKHYDLL.TESFKLARKGF.....-.SDSP....VLLPDELE.............INDSEDR--ET..VRVANLATT.A...ISVF..GAND..VAC...KDLDDSFFSIFVPEDG.................................................EFKDTLADLLLSLKTQAFLDSLD............................................eQATPQQVTEQLD.KFFPDNFED.WLKQRNLD.............VVTDT..DADQLAVKIKDRRELLSTLAN.SEQPKKS---KYP..PDTFPETLCAFLQSHIG.....VVVEYAEEYGVKIP-ise.................................................
Q1K5E8_NEUCR/270-508             ...................mirsm---SL.PVLGNL......................AVQILLRLSQ...QPr..nETLSLLSETDA................EFRKHYDLL.TESFKLARKGF.....-.SDSP....VLLPDELE.............INDSEDR--ET..VRVANLATT.A...ISVF..GAND..VAC...KDLDDSFFSIFVPEDG.................................................EFKDTLADLLLSLKTQAFLDSLD............................................eQATPQQVTEQLD.KFFPDNFED.WLKQRNLD.............VVTDT..DADQLAVKIKDRRELLSTLAN.SEQPKKS---KYP..PDTFPETLCAFLQSHIG.....VVVEYAEEYGVKIP-ise.................................................
A6ZWC4_YEAS7/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
H0ZCM5_TAEGU/12-207              .....................vng-----.WVLQFY......................FHRAIEAYRS...--....-----------................GRNRDFRQF.RDIMQALLVRP.....L.DREP....--------.............DVTQMLRIMQL..LSRVEEGEN.L...DCTF..DKEL.eLTP...LESAMLVLDFIREEFS.................................................VADRTMETVQKMVKEAAVVVCIR.............................................NKEFEKASDIVK.KHFGKEPRN.--------.............-----..---------QKKRNEWLAVIR.EKNPSHPKVKNFS..YEDFQQSIFGFLKGYMDdsepaLL-------------tlagatedle..........................................
H2AZB9_KAZAF/33-312              .......................t-ISSL.CLLDNI......................STQLLRFLIFnsnSP....QIIALYSDSQSni............ssGETEIFQTL.LKLFKQVRLIY.....N.TRTP....LLNVHDVApglwfpnspppllLRGHEAYIITA..IRKANLLTF.I...LTAI..GCFN..YGF...ELLQSTFLDIFCPNTLftgta......................................stdqngKFLKSQAILYLDLKTQAFIAGLKefk......................................sdtnGIPKEKQEEILK.LVFPDNLAE.QLILRRTGssn......lgtnGTMTP..SERDFIERCERRKDNLL----.QFDQFDSLIESYD..FNHFIKEILDYCNRNMG.....LIIWGKKGRGKSP--lys.................................................
Q539Y9_MUNMU/70-267              .....................aag-----.WMLDFL......................CVSLCRAFRD...--....-----------................GRSDDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLKTIYVCQF..LTRIAAGKT.P...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIENLIKIQAIAVCME.............................................NGNFKEAEEVFE.RVFGDPNSY.--------.............-----..---------TPFKRKLLTIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVSCVLNeksstFLMKAAAKVVETKR-art.................................................
E7R690_PICAD/202-502             ........................LINTL.PVLDNL......................ATQILRIISQ...GPy..qKIMELVSNRES................FAGIAFGNL.IELFETTKRVY.....NsEESP....FFTVENVTfglwkygeaapefFRGKEDTIEGT..LRKVNLATF.L...LATL..GLID..LGF...FFLNEAFLDVFCPPQNldptrslsnlkqdntlqst...........llsssypfaqssrapnnqtKFLKSHAILFLELKTQAFISAIE.............................................-LGDRSKEEILK.DLFPDNLDE.ILLKRKQPdfdtskhtivrnsTLFTP..AELDFLARCDSRKDNLM----.NMKADDSLMEKYE..WIKFLNDLLDYVSKNVG.....FLIWGPKGKITKE--ltr.................................................
TBF1_YEAST/29-306                .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
Q8JGS4_DANRE/14-210              .......................i-NR--.WSFDFY......................AFQAFSAFRN...--....-----------................GDYTAFTHF.INIIESVVVRP.....V.DGHT....--------.............DMIPKLRLMQF..LSRINNGDK.L...DLTF..EEPK..-TP...LESALDVLESICRDMS.................................................VPHTEQQLIRHAISEMLVMVCIR.............................................SGEFEKAEEMLK.HFSSSSDSA.--------.............-----..----------GKKKLLLHLIR.CRRSSHTVLQLSS..YSHFKQDMLQFVERLFSvpepfLLQMLRRSGWPSQ--rpe.................................................
B8LTG8_TALSN/193-431             .......................k-IQSL.PILDNL......................STQILSLLAK...SSy..qDITSFVSEPES................ENGQAYATM.RSLFDHTKRVY.....S.TKQA....FLSPTDLD.............LTDPTQI--DI..IRKANLASF.V...SSIF..GSQE..ISF...AELNDHFIDVFVPEGS.................................................RLLKVQGALFLELKTQAFIASLN.............................................-NEERTRTEILF.ELFPDDLEQ.RLLSKRTG............tRQLAP..SEADFVKRARSRRDIIFADIN.NEEAMKALPDKYH..WEDFLRDLSAYISKNFE.....TINSLQSRKL-----vkgrqs..............................................
G3JEU7_CORMM/137-364             ....................vqaq-----.-TLGNL......................SFTLLYSLVQ..hQPi..dEIIRAIRNAES................DHGGIFRHL.QDSLESVWKLF.....T.TNDT....-ISAEDIN.............VESNAST---L..LEMANLAKL.C...IWLV..KATA..ESY...SIADSKLLTIFNCQVS.................................................DLPITATELYLGIKTQNCIQQLI............................................nKTDDQQAEQLVA.QSLTQGLGD.KLKAQHPE.............DSLLN..ADQAFITLATVRKTDLINETR.EGIDTESLTKKYP..ADELLRTFATYARSRLA.....---------------avadvgs.............................................
Q539Y6_MUNMU/52-251              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVWP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESATNVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNSS..YETFQQKMLRFLESHLDdaepcLLTMAKKALKSES--sts.................................................
C1GE42_PARBD/147-384             .......................k-TQSL.PILDNL......................STQILTLLAQ...SSy..qDFTSMVSEPNS................DSGQAYSTM.RSLFDHTKNVY.....S.SKGS....FLSPRELD.............LTEPTQV--DI..IRKANMASF.V...SSIF..DSQE..IGF...SELDANFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SAKRSKTELLH.ELFPDDLEQ.RLLSRRPG............tKQLAP..SETDFVNRAYSRRDILLNEVN.NPAAAAKLPEKYR..WEDFLRDLSSYVSKNFD.....AISHQQTKKPSK---grp.................................................
Q71M47_CHICK/37-236              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAVSNGF.....S.KVTM....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
C5PD10_COCP7/178-416             ......................kt--ESL.PILDNL......................ATQILSLLAR...SSy..kDITSIVSEPNS................ENGHAYSSM.RSLFDHAKKVY.....S.TNGP....FLSATQLG.............FTKPGQI--DI..IRKANMASF.V...SSIF..GTQG..IGF...SELHDHFLEIFVPEGS.................................................RLLKGQGALFLELKTQAFIASMN.............................................-NSEQGRREILR.NLFPDDLGL.KLLARRPG............nKQLAP..SETDFVKRAWSRRDILLAEID.NPESVRTLPERYR..WEDFLRDLSSYVSKHYD.....STTTQASKGPS----vesgd...............................................
A1DE41_NEOFI/181-419             .......................k-IQSL.PILDNL......................STQILSLLAK...STy..qDITSFVAEPES................ENGQAYATM.RSLFDHTKKVY.....S.SKES....FLSPTELG.............LTEPSQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...AELNEHFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERTRTELLY.DLFPDDLEQ.RLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....AICHQQTKKL-----nkgrqp..............................................
F6T659_HORSE/70-267              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ESDE.rITP...LESALMIWASIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------TPFKRKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLNeksstFLMKAAAKVVESKR-trt.................................................
G3RM03_GORGO/30-187              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------------------.-------------..-----------------.....---------------qqdfenvenilsrnrsarpil...............................
E7KVI1_YEASL/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
A1CBA1_ASPCL/180-418             .......................k-VQSL.PILDNL......................STQILSLLAK...STy..qDITSFVSEPES................ENGQAYATM.RSLFDHTKKVY.....S.SKQS....FLSPTELN.............LTEPAQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...AELNDHFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERTRTELLY.DLFPDDLEQ.RLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLNEVN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....AICHQQTKKINK---grqp................................................
E9QM06_MOUSE/97-297              .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKLRTDLLNIIR.EKNLAHPVIQNFS..YEVFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aass................................................
G2QPB3_THIHA/246-487             ...................vmrsm---SL.PVLGNI......................AVQILLRLSQ...QPr..sETESLLANPTS................EFRKSYDML.RDIFVATRKAF.....-.CDSP....LLSPDELD.............VTDSEDR--ET..IRMSNLAAT.A...VSAF..GAHD..VAV...QDVHDAFFSIFIPEDG.................................................EYKAPLTDLLVSLKTRLLLDALN............................................kPEQSQPVSQLLG.ALFPANFDD.SLRQRSGD.............MILNA..DEEALVLRIRERREQLVKSAA.DESIKALLEEQSS..ATMFTESLSAFLQSHLG.....VVVDYAEKYGVNIP-lse.................................................
G3WL30_SARHA/70-242              ......pscfpallvrplgkehti-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............--SRLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLETIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKAARILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLGIIR.ERNITHPVIQNFS..YETFQQKMLRFLESHMDdaepyLLTIAKRALKSES--ssss................................................
F1NSI5_CHICK/27-225              .......................v-NR--.WVLQFY......................FHQAVAAYRA...--....-----------................GRNRDFRQL.RDVMQALLVRP.....L.EREP....--------.............AVAQMLRVMQF..LSRIEEGEN.L...DCTF..DKET.eLTP...LESAIGILQLIAKEFS.................................................VPEKKIELIHKVLKEAAVIVCIK.............................................NKEFSKALAVLK.RHMEKDTGN.--------.............-----..---------QKKRTELQTIIR.EKNRAHPIIKDFS..YVNFQQYMFQFLKTYVDts.epLLVTMMKSLNSERA-ee..................................................
F7F089_ORNAN/2-176               ...........lsaiihglsklss-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............HQRRTIYICQF..LTRIAEGKT.L..eDAQF..ESDE.rITP...LESALSIWSSVGKDQV.................................................LSDKLSEEIRDLIKIQAVAVCLE.............................................KGNIKEAEEVLE.RVFGESNPN.--------.............-----..-----SPDPDSLKLKLLTIIS.RKDPYHPFLQHFS..YPCMMEKIKSFVDLIIHekasgFLVREATKVVDNQ--raqt................................................
E7QAA6_YEASB/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
Q2LK75_XENLA/16-215              .....................vat--N--.WMCDFM......................FASMCFYFRE...--....-----------................DRTEDFQRS.THMLEWLLEGS.....Q.KIDA....--------.............-HRKTIPIAQF..LMRVAEGKN.L...DSQF..DTDE.sLTP...LETALMAFNQIEEEED.................................................-LKHLHEEIELLLKVQAVVTCME.............................................KGRFKLSAEILD.RLFKESGSN.--------.............-----..---------KYLRMKLTMLIE.KKDPYHEFLQNFT..YAQMMKKIKSYIALKMKerpsvFLLKAAAKVVEATA-kee.................................................
F7FB99_MONDO/22-222              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................GRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TISRLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLETIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLGIIR.ERNITHPVIQNFS..YEIFQQKMLRFLESHMDdaepyLLTMAKRALKSESA-sts.................................................
Q539Y5_MUNRE/52-251              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSE---ssts................................................
A6S1Q0_BOTFB/156-390             ................tdhqlslq-----.------......................AVQMLNILSE...GGy..dEIVVMVTQRDT................ARGLSFQTL.NDLFDKTKRIY.....-.GTST....FLSADELN.............IIDPAQR--EI..IRLANHATF.V...SSVF..GGQE..VGF...YELNEHFVNTWTREGE.................................................AISKASGQLLMNLKTQIIVAALS............................................mEESDKPVEDLID.EIFSPEFRN.LLSHRHP-.............YPLTD..DELQLLVDLDIRRVYLINQGN.DPAKIKELSDLFN..WDSFLRSTHIHMDAYRP.....LVEPYMSKYGLTIP-ts..................................................
A7F6Z9_SCLS1/147-385             ....................lqvl---SL.LSLESL......................SVQMLNILSE...GGy..dDVVVMVTQRDT................PRGQSFQTL.KDLFDRTKKIY.....-.GTST....FLSADQLN.............FRDPAQR--EI..IRLANHATF.V...TSVF..GGQE..VGF...YELNEHFVDIWTREGE.................................................PISKASGQLLMNLKTQIIVAALS............................................mEESDRPVPELIA.EMFSSEIRN.FLAQRHP-.............YPLTD..DERQLLLDLEIRRVYLINQGN.DPAKINELCNLFN..WESFLRSTHIHMDAYRP.....LVEPYMNKYSLTIP-ts..................................................
G5AK43_HETGA/58-258              .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYADFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAMNVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPST.--------.............-----..---------QKLRSDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aats................................................
C5DEV8_LACTC/34-307              .......................n-INSI.GLLDNV......................STQLLKLLMT...SSi..eTLIGFTSAQSD...............gYQSEVFEML.FALFKQVKKVY.....-.TSAP....LLVVQDIApglwledekcpyiLKNQENLVLAA..IRKANIVTY.L...LSIM..GRLQ..YGF...LFLDESFIEIFCPVAGdlpfeae..................................ralttslgRLLKPQAVLYLNLKTHAYISAIEpyr.......................................dnaEALSRVREEILD.RIFAKNMEQ.FILAKRRMr...........sSKLSP..SEEDFVKRCVHRREKLQ----.SQDSLDLLVAEYD..WLEFFKEIFFYLQRNIS.....VLVWGKKGCDFAS--pgsd................................................
H2PP90_PONAB/73-268              .....................aag-----.WMLDFL......................--PLCGAFRD...--....-----------................GSSEDFHRT.LNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAEF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQATAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPLKSKLLMIIS.QKDAFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAEAKVVESKR-trt.................................................
C4JRW1_UNCRE/171-400             ......................rt--QSL.PILDNL......................ATQILSLLAR...SSy..qDITSIVSEPNS................ETGHAYSSM.RSLFDHAKKVF.....S.TNGP....FLSASQLG.............FAEPGQI--DI..IRKANMASF.V...SSIF..GTQE..IGF...SELHDRFLDIFVPEGS.................................................RLLKGQGALFLELKTQAFIASMN.............................................-DKEQSRFQVLH.NLFPDDLGH.KFLARRPG............nKQLAP..SETDFVKRAWSRRDILLADID.NPESINTLPERYR..WEDFLRDLSSYISKHFD.....SITNQ----------vc..................................................
G0RL26_HYPJQ/142-376             ....................anth-----.-ALGNL......................ALSVLLILLQ...QPi..dDMSKLAGDADS................GYGRSYGRL.KRSFDATWQLF.....-.SDSQ....VLSADELE.............IQEAEAR--TL..LELANIAKF.G...MWLV..EGGL..DSF...TAAERNFTSVFRCQIS.................................................DLSPALSQLYVEMKTYKAIESLI.............................................KDGEGLSIEEVV.HVVQKTMLD.GLNDSSAS.............EPMST..SQQELLTLAKARKDVLEEELK.VKQP-AALKEKFP..PGDVLKSFSAHVRTLLA.....---------------smtevgeklgvsalls....................................
F1R8I5_DANRE/50-245              ....................vvqs-----.WIIDYY......................FATLCRLFRE...--....-----------................RSSVEFRKE.LKLFEGLVDEL.....E.SHSS....--------.............----QRTVCCF..LARVMDGEN.L...DVRY..DHVA.rITP...LMSAVPVWESLKDFSD.................................................--PTLHGKIQTLLMVQSVSVCVK.............................................KGYDKLAKETLQ.WLEEQTDVP.--------.............-----..---------EKLQRKLATIVN.KKDAYDQILMNFS..FDKLMETIDTFLEAFNQqyasvFLLEAASKVVQARH-ers.................................................
TERF1_CRIGR/74-271               .....................aag-----.WMLHFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............CQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIPAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YYHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
E2R1W7_CANFA/70-270              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFHRA.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKS.LvlkDAQF..ETDE.qITP...LESALMIWASMETEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFDDPNSY.--------.............-----..---------EPLKRKLLVIIS.QKDTFHSIFQHFT..YNHMMEKIKSYVDYVINekssaFLMKAAAKVVESKR-srt.................................................
F6TW69_MACMU/52-249              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQGEGRAG.....-.GRGL....--------.............--ERRGRGCKC..ILKWKLCFV.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
G2XTH2_BOTF4/162-400             ....................lqvi---SL.MSLECL......................AVQMLNILSE...GGy..dEIVVMVTQRDT................ARGLSFQTL.NDLFDKTKRIY.....-.GTST....FLSADELN.............IIDPAQR--EI..IRLANHATF.V...SSVF..GGQE..VGF...YELNEHFVNTWTREGE.................................................AISKASGQLLMNLKTQIIVAALS............................................mEESDKPVEDLID.EIFSPEFRN.LLSHRHP-.............YPLTD..DELQLLVDLDIRRVYLINQGN.DPAKIKELSDLFN..WDSFLRSTHIHMDAYRP.....LVEPYMSKYGLTIP-ts..................................................
TERF2_CHICK/27-225               .......................v-NR--.WVLQFY......................FHQAVAAYRA...--....-----------................GRNRDFRQL.RDVMQALLVRP.....L.EREP....--------.............AVAQMLRVMQF..LSRIEEGEN.L...DCTF..DKET.eLTP...LESAIGILQLIAKEFS.................................................VPEKKIELIHKVLKEAAVIVCIK.............................................NKEFSKALAVLK.RHMEKDTGN.--------.............-----..---------QKKRTELQTIIR.EKNRAHPIIRDFS..YVNFQQYMFQFLKTYVDts.epLLVTMMKSLNSERA-ee..................................................
G3UUZ0_MELGA/25-177              .....................aad-----.WVLEFS......................CCCLCRHFVE...--....-----------................ECGAEFGRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECQF..ENDT.rISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQAATKQVE.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------skggevrvlqnktlnvkeekennleakqrlteelwst...............
H0V1J1_CAVPO/94-293              .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYADFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAMNVLEMIKTEFT.................................................LTEAMVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPST.--------.............-----..---------QKLRSDLLNIIR.EKNLAHPVIQNFS..YEIFQQKMLRFLESHLDgtepyLLTMAKKSLKSE---svvs................................................
G3I013_CRIGR/106-173             ...................lvkea-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...----..----..---...----------------.................................................-----------------------.............................................------------.---------.--------.............-----..----------KLRTDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aass................................................
H2NRC6_PONAB/52-251              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALRSE---saas................................................
Q75C21_ASHGO/34-327              .......................t-LKSL.PLLNDI......................STQLLRLLTI...TPl..hVLTGSVQEDKAa..............qAEHELFHVL.VDALIEVKEVY.....-.GDTS....LLTVYDVApgiwfpgcdppliLRNFEQFVLAT..IRKCNLVMF.M...LTLL..GKFQ..YGF...QFLNECFIDIFCPSNSystsdggkdtgsysvqsna...........sftpctstfsgsltsaiggRLLKTHTVLYLNMKTQAFIAAME............................................qEDPLLNRKQILD.TLFPADMAT.YLQLKSGEpa.........neFQLTP..SEKDFITRCQRRRETLE----.ANTDLRDIMELYK..WSDFLKEFLAYVSKNVS.....LLVFGKRAKCAAPK-qf..................................................
B9WB93_CANDC/319-596             ........................LINTL.PTLDNL......................ATQLLRTVAT...SPy..qKIIDLASNPDT................SAGATYRDL.TSLFEFTKRLY.....S.EDDP....FLTVEHIApgmwkegdetpsiFKPKQQSIEST..LRKVNLATF.L...AATL..GTME..IGF...FYLNESFLDVFCPSNNldpmnalsnlgsyq....................ngfqttdspigakvgKLLKPQATLYLDLKTQAYISAIE.............................................-AGERSKEEILD.DILPDDLHM.YLMSRRDA.............KLLTP..TETDFVWRCKQRKESLL----.NYNEEIPLSEQYD..WFTFLRDLFDYVSKNIA.....FLIWGKVGKTMKNRRe...................................................
G5B5U0_HETGA/70-268              ...................avatg-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFHRI.RDSTEAIIHGL.....P.SLTA....--------.............DQLRTVYICQF..LTRIAAGKS.L...DAQF..ESDE.rITP...LESALMIWASVEKQHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................HGSFKEAEEVFE.RIFGDPYSH.--------.............-----..---------TTLERKLLMIIS.QKDPYHSFFQHFS..YNHMMQKVRSYVNCVLGeksstFLMKAAAKVVESEK-tr..................................................
G7XT60_ASPKW/146-384             .......................k-IQSL.PILDNL......................STQILSLLAK...SSy..qEITSFVSEPET................ESGQAYATM.RSLFDHTKKVY.....S.SKKS....FLSPTELE.............LTESSQI--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NSERTRTELLY.DLFPDELEQ.QLLDRRPG............tRQLAP..SEADFVKRAGSRRDILLSDVN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....TISNQQTKKTAK---grqp................................................
G8BDW4_CANPC/257-544             ........................LINTL.PTLDNL......................STQLLRIVAK...SSy..kKIIDIASNAET................PEGATYRDL.TSLFEFTKRLY.....S.EEDP....FLTVDHIApgmwhtgeetprvFKNKEQSIEST..LRKVNLATF.L...AAAL..GTME..VGF...FYLNESFLDIFCPAHDldikyhlsdssyldtans.............lattiqsgagsnvggkigKLLKPQAMLYLDLKTQAYISAIE.............................................-AGERSREEILE.DILPDNLDQ.ILLARRNV.............DLLLP..SEADFVERCRSRKAFLL-NYN.EDETQIPLSEEFK..WFTFLRDLFDYVSKNMG.....YLIWGKSGKPVREK-ke..................................................
G8BUL2_TETPH/28-350              .......................s-ISTL.SSLDNV......................SNQLLSIISS...DSf..nSETYLLFNPRNvns..........ripMAIKSFHSL.LTIFIEILRVYgidndV.GEFK....ILEPKHIVkdmwyqdsptlvlLKTFEKDIITT..IRKCNVLIY.F...LTVL..GCLN..FKI...DKLQEDFLDVFAPNTLfeesp.......................................fnineQLLRKQWLLYLDLKTRIYIEKLKrvryeklraeraenpninlifqnqedsnkesgheqatsneiskfdHVSEDERSELLEnNLFSNTFTN.ELVLRRTKss.........adPTLTT.sFERVFVQRYITRKANLM----.SFSSLKKLEIEIS..EKSFITNLKDYCDRYMS.....LIIWGTKHRNSKNP-iqt.................................................
E7M151_YEASV/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
G8JXM0_ERECY/35-337              .......................r-IKSL.PLLNNV......................STQLLRILTM...TSpqtlANTILGSRCDT................AECRLFHSL.LDLLEQVKLIY.....-.GDMP....LLTVYDVApgiwfpgwdapsiLRGFEQSILTT..IRKCNLATF.M...LTLL..GKFD..YGF...QFLNDCFIEVFCPSSYvpsvdlakepvpppplppskggggggglyssysgsnggtnvalsssaggKLLKTHTVLYLNLKTQAYIAAIS............................................dTGVTSDRKQVLD.ALFPQDMAA.YLKNKSGEsa.........ndFQLTP..SERDFITRCQRRRETLE----.ANTNLHEIMQLYK..WSDFLKELLAYVSKNIG.....LLVFGKRGRG-----vlqs................................................
H9G7L7_ANOCA/4-196               .......................v-NR--.WALLFY......................CHRAVQAFRE...--....-----------................GSSRNFRQL.RDVIYAVLARP.....L.ALEQ....--------.............SILLQLRIIQL..LSRIEEDEN.K...DWTV..DIST.qLTP...LECALHLLKKMSSEFT.................................................VDANKFEEIHQKVAEAAVVSCIK.............................................NKEYNRAKRILK.KYKPKDPST.-LKKR---.............-----..---------------------.-------------..-----------------.....---------------ilyhsiiqekehsnpailrfpfeffqqsvlvllesyiedseplllmvsaisg
G1LHE9_AILME/70-270              .....................aag-----.WMLDFL......................CLSLCRAFHD...--....-----------................GRSEDFHRT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKS.LvlkDAQF..ETDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIENLVKIQAIAVCME.............................................NGNFKEAEEVFE.RIFDDPNSY.--------.............-----..---------EPLKRKMLMVIS.ERDTFHSIFQHFS..YDNMMEKIKSYVNYVINekssaFLMKAAARVVESKR-art.................................................
H3BR37_HUMAN/1-118               ........................-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............--------MQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKM---------.....---------------....................................................
F9FID1_FUSOF/145-371             ....................asrh-----.-ALGNL......................ALSVLLLFSQ...SF...dDSIKHIQDADS................QHAKSFRDL.QASFAQIKQIY.....-.SSGP....ILSADDPD.............LHDHESR--TI..LDLANLAQF.G...IWLL..QTTP..-SY...SEAHQHFHAIFRGQVS.................................................DLGSDALDLYLSLKTQVAIDALA............................................aKTQEQSKEQVLE.EALINGMEE.KLRGLHNG.............FDLTP..ADSEFITSVRSRKTSLE--GE.ASTESAVLREKYK..VDDLLRQVSTCVKTRLA.....LM-------------sdlgsrlg............................................
Q0CW12_ASPTN/175-413             .......................k-IQSL.PILDNL......................STQILSLLAK...STy..qDITSFVSEPDS................ENGQAYATM.RSLFDHTRRVY.....S.TKKS....FLSATELE.............LTEPAQI--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERSRTELLY.DLFPDDLEQ.QLLDRRPG............tRQLAP..SESDFVKRAGSRRDILLSDIN.NEEAMKALPDKYH..WEDFLRDLSSYITKNFD.....MINNQQTKKIVTKGRq...................................................
B2Z8W7_PNECA/139-373             .......................c-IQSL.PILDNL......................SSQILSILGK...GPh..qETLNIVTRPDT................AKGQAYRTL.TSLFNQVKKLY.....-.STEA....FLNPDLLD.............LRAPQHR--AT..IRKVNLATF.V...SSVF..GSVE..VGF...FHLNEHFLDTFVPDGA.................................................RLLKSQSALFLNLKTQAYISAID.............................................-QGEKPKEEILD.DLFPPNMDQ.ILLQRRNG............aKSLTP..NESDFVARCKSRKNHLA----.KFPINENLSEKYV..WQIFLRDVSEYITRNYE.....SIVSQP---------irrhrrvsskm.........................................
A3KP67_DANRE/17-212              ....................vvqs-----.WIIDYY......................FATLCRHFRE...--....-----------................RSSVEFRKE.LKLFEGLVDEL.....E.SHSS....--------.............----QRTVCCF..LARVMDGEN.L...DVRY..DHVA.rITP...LMSAVPVWESLKDFSD.................................................--PTLHGKIQTLLMVQSVAVCVK.............................................KGYDKLAKETLQ.WLEEQTDVP.--------.............-----..---------EKLQRKLATIVN.KKDAYDQILMNFS..FDKLMETIDTFLEAFNQqyasvFLLEAASKVVQARH-ers.................................................
H2R473_PANTR/74-271              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSH.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
G1KPX9_ANOCA/43-242              .....................aag-----.WMLDFA......................CRCLCRHFCE...--....-----------................ENWAEFERS.RDLALTIIKGL.....N.KIEI....--------.............HRMKTVCLCQL..LAYIGEGKS.I...DPHT..KSDQ.rLSP...LENAYLVWTSFLKVQS.................................................KHEKLHEEIKRLIQIQAVAVYME.............................................KGYFNKATEVVQ.RLFPESLTN.--------.............-----..---------EPLRMKLSAITK.EKDPYHRFLLHFD..FRLLLEKIKSYVTVFLNeesnnFLIKEATKEVES---rcag................................................
B8QB44_XENTR/23-222              .......................i-NQ--.WVFDYY......................FHTAVEAFRS...--....-----------................DRRKDFQEI.RDIVSVLLHHP.....L.EIKA....--------.............QNDCKLRIMQC..FSRIEEGED.P...DCTF..NEEN.nETP...LESAVGLLDIIQKEMP.................................................LDEDLLRTNKQMVKEAAVLVCIK.............................................SQKFDQAIRILK.KYISNNNKR.--------.............-----..----------KLRSDLQTIIR.EKNQNHPLIANFS..FTTIKKMIYQLFEKHIEltapvLLTMAKKEQKSQC--lsee................................................
B5XG60_SALSA/22-148              .......................v-NR--.WTVDYY......................ISVALEAFRN...--....-----------................EQYPDFCQI.RDILQCHLVRP.....L.EAND....--------.............VTPKKIRAIQF..LTRINDGDK.L...DVSF..DSQE.dLTA...LESALSVLDSIREELP.................................................VPQKDLERVHKCIRE--------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------maagklmvkrqgagqdaee.................................
A6QU00_AJECN/180-418             .......................m-TKSL.PILDNL......................SSQILTLLAQ...SSy..qDLTSIVSEPNS................ECGQAYSTM.RSLFDHTKNVY.....S.SKGS....FLSPRELD.............LTEPSQM--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQHFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SGKRSRTEILY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRVFSRRDILLNEVN.NPEAASALPQKYR..WEDFLKDLSSYVSKNFE.....AISHQQTKKSSK---grps................................................
Q2UEB6_ASPOR/175-435             .......................k-IQSL.PILDNLvsiileqrfffawikyvltfiqSTQILSLLAK...STy..qDITSFVSEPDS................ENGQAYATM.RSLFDHTKKVY.....S.TKKS....FLSATELE.............LTESSQV--DI..IRKANLASF.V...SSIF..GTQE..IGF...SELNDNFLDVFVPEGG.................................................RLLKVQGALFLELKTQAFIASMN.............................................-NTERSRTELLY.DLFPDDLEQ.RLLERRPG............tRQLAP..SETDFVNRAKSRRDILLNDIN.NEEAMKALPDKYH..WEDFLRDLSSYVTKNFD.....TISNQQSKKITK---grqp................................................
G1TE57_RABIT/93-293              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKMKNDLLNIIR.EKNVAHPVIQNFS..YETFQQKMLRFLESHLDdtepyLLTMAKKALKSQS--aass................................................
C5M6U1_CANTT/454-731             ........................LINTL.PTLDNL......................ATQLLRTVAS...NPy..qKIIDLASNPDT................PEGATYRDL.TSLFEFTKRLY.....S.EEDP....FLTVEHLApgmwkegdetphiFKSKQQSIEST..LRKVNLATF.L...AATL..GTME..IGF...FYLNESFLDVFCPSNNldpanalsslgsfq....................ngfqstenpigakigKLLKTQASLFLDLKTQAYISAID.............................................-AGERSKEEILE.DILPDNINE.YLMSRRDV.............RILTP..TETDFIVRCRQRKELLL----.NYNSDTHLSEEYE..WFTFLRDLFEYVSRNMG.....YLIWGRMGKSVRDR-re..................................................
Q7T1R9_CHICK/37-236              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAVSNGF.....S.KVTM....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
Q5R6X2_PONAB/71-267              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-tg..................................................
D3ZJF7_RAT/91-290                .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRRLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKVRTDLLNIIR.EKNLAHPVIQNFS..YEIFQQKMLRFLESHLDdtepyLLTMAKKALRSE---saas................................................
C4QXZ4_PICPG/92-384              ........................LINTI.PTLDNL......................ATQILRIIAQ...GPy..qKILDIVANQDS...............tLAGISYKNL.IELFEMTKRIY.....S.TEDP....FLNVEHLTfgiwkygceppsfLKGKEDSVEST..LRKVNLATF.L...NATL..GTND..AGF...YHLNESFLDVFCPSQSldpsntmtnltgnsis................gyqegetqrtsanfvpgKLLKSQAGLYLDLKTQAYISALE.............................................-INERPKDEILE.DLFPDNMDE.ILLKRKNPdmelq..lpinksTAFTP..AESDFISRANIRKQRLQ----.ESDNDSKLAETYE..WLVFLKELFDYVSKNVG.....ILIWGRRGR------lgnlsq..............................................
TRF1_SCHPO/96-332                ....................llrt---SLiPTLGNL......................SNIILSILGK...-Pv..qEASAIVTNPAS................EMGMAFTKV.MNMFRMVKDIY.....-.TEES....FIYSSAIG.............MRTPSQR--ST..TRRANLAIF.L...AAVY..GALQ..IGF...FHLNENFLEVFAPDES.................................................NILTNQGTLYMELKTQAYISAMA.............................................-QAERPKGDILN.DLFPSDMAH.RFLIRRNAk..........ldDKLTY..VEKQIIEKCTARKERLA----.NFSPQEALNEVYP..WGKFLSEIACYIHNNYS.....SISAIPIPANSFK--rrs.................................................
B8QB43_XENTR/16-213              .....................vat--N--.WMCDFM......................FASICFYFRE...--....-----------................DRTEEFQRS.ANVLEWLLEGS.....R.KIDA....--------.............-HRKTIPIAQF..LMRVSEGKN.L...DSQF..DTDE.sLTP...LETALMTFNQIEEEEN.................................................-LKNLHEEIELVLKVQAVVICME.............................................KGKFKLSSEILD.RLFQESGSN.--------.............-----..---------TYVRMKLAMLIE.KKDPYHEFLQNFT..YAQMMKKIKTYITLKMKarppvFLLEAAAKVVE----avak................................................
H2M8A8_ORYLA/18-194              .....................vnr-----.WIVDYN......................LSLALELFKK...--....-----------................QQFEDFNEV.RNVLSVVMKRP.....V.EATS....--------.............DMPLKIRMLQF..LGRINEGEN.L...ELIY..DPGT.pVTP...LESALLLLENIMEAFG.................................................IPQQDWEDASNSLKVMIVATFIK.............................................NGNFDKAAQMLN.KYFPKPVGR.--------.............-----..-----------VRNILEGLIR.QKNKTSN---SFS..FQLFKQEMLAFVQR---.....---------------lcyfdv..............................................
F2PSD1_TRIEC/171-409             .......................k-AQSL.PILDNL......................STQILSFIAR...TSf..qDLTTLVSEPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TNKP....FLSASELG.............FTEASQV--EV..IRKANLASF.V...FSLF..GTQE..IGF...AELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPSRPKVEILY.ELFPDNLGL.SLLARRPG............tRHPAP..SETDFVKRASSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....ALTTQVCTKR-----lnktrs..............................................
F7IQX2_CALJA/71-268              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRQT.RDSAEAIIHGL.....S.SLTA....--------.............YQLRTVYICQF..LTRIAAGKN.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIEVQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNS-.--------.............-----..--------CAPLKRKLLMIIS.QKDTYHSVFQHFS..YNHMMEKVKSYVNDVLSeksstFLMKAAAKVVESKR-art.................................................
E7NNT0_YEASO/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSX..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
B9EM55_SALSA/22-148              .......................v-NR--.WTVDYY......................ISVALEAFRN...--....-----------................EQYPDFCQI.RDILQCHLVRP.....L.EAND....--------.............VTPKKIRAIQF..LTRINDGDK.L...DVSF..DSQE.dLTA...LESALSVLDSIREELP.................................................VPQKDLERVHKCIRE--------.............................................------------.---------.--------.............-----..---------------------.-------------..-----------------.....---------------maagklmvkrqgagqdaee.................................
Q4QRH9_DANRE/14-210              .......................v-NR--.WSFDFY......................AFQAFSAFRN...--....-----------................GDYTAFTHF.INIIESVVVRP.....V.DGHT....--------.............DMIPKLRLMQF..LSRINNGDK.L...DLTF..EEPK..-TP...LESALDVLESICRDMS.................................................VPHTEQQLIRHAISEVLVMVCIR.............................................SGEFEKAEEMLK.HFSSSSDSA.--------.............-----..----------GKKKLLLNLIR.CRRSSHTVLQLSS..YSHFKQDMLQFVERLFSvpepfLLQMLRRSGWPSQ--rpe.................................................
H0GPI8_9SACH/29-306              .......................t-ICSL.CLLDNI......................STQLLRFLILnanSP....NIIAVLTDQTAfl............ssGETEIFQTL.VKLFKQIRMIY.....H.TRSP....LLSVHDVApglwfpnspppliLRGHEAFIITA..IRKANLLTF.L...LTSL..NCLN..YGF...ELLQSIFLDIFCPNTNtvgnn......................................sleqsgKFLKSQAILYLDLKTQAYIAGLKefq......................................detnEISLEKKQELLD.LIFPSNLAD.ILVQRRTGds........gdiTLLTP..SEKDFVERCDRRRENLK----.IVQDFNSLTQSYE..WAQFIRELLDYCNKNMG.....LIIWGRKGRGKSP--lyd.................................................
H9FHN7_MACMU/12-212              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
H2PQJ8_PONAB/71-267              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-tg..................................................
C4XYR9_CLAL4/362-640             ........................LINSL.PVLDNL......................ASQLLRVFAI...GPy..qKIIDLASSPET................PSGAAFRDL.TSLFEFTKRLY.....S.EEDP....FLTVEHLApgmwkegektpsmFRSREQTIEST..LRKVNLATF.L...AATL..GTIE..VGF...FYLNESFLDVFCPYNNldpansmsnmnpsnm...................slqsgvntiigdkvgKLLKSQAVLYLDLKTQAYISAIE.............................................-AGERSREEILE.DILPSNLEQ.ILLERRGV.............KSLSP..SEVDFVARCKSRKETLL----.NYPEGSNLSEEYE..WFEFLKEMFDYVAKNMG.....FLIWGKRGKPHTR--ser.................................................
F1QDP9_DANRE/32-220              ....................vvqs-----.WIIDYY......................FATLCRLFRE...--....-----------................RSSVEFRKE.LKLFEGLVDEL.....E.SHSS....--------.............----QRTVCCF..LARVMDGEN.L...DVRY..DHVA.rITP...LMSAVPVWESLKDFSD.................................................--PTLHGKIQTLLMVQ-------.............................................KGYDKLAKETLQ.WLEEQTDVP.--------.............-----..---------EKLQRKLATIVN.KKDAYDQILMNFS..FDKLMETIDTFLEAFNQqyasvFLLEAASKVVQARH-ers.................................................
E9DRY6_METAQ/139-374             ....................naha-----.--LGTL......................ALSLLLVLVQ...SPf..eDTIKLVRGSDS................QHEQTFRKL.KSSFEHVHEMY.....-.SSGP....VLSANELE.............FRDSDSR--TF..IELANLAQL.G...SWLV..DGTP..KAL...SEADENFLAMFQCQLS.................................................ELPPGMTELYLGIKTQRAIEFLV............................................eKEPEKPSEEVIG.EVLTQGLVH.TLKEQHGG.............GDLTS..ADQSFVSSVQTRKETLQGEVK.EEPEPAALREKHP..AEDLLRSFLEYTTGRLK.....SLTD-----------vgdklgitieis........................................
F6Z552_XENTR/23-222              .......................i-NQ--.WVFDYY......................FHTAVEAFRS...--....-----------................DRRKDFQEI.RDIVSVLLHHP.....L.EIKA....--------.............QNDCKLRIMQC..FSRIEEGED.P...DCTF..NEEN.nETP...LESAVGLLDIIQKEMP.................................................LDEDLLRTNKQMVKEAAVLVCIK.............................................SQKFDQAIRILK.KYISNNNKR.--------.............-----..----------KLRSDLQTIIR.EKNQNHPLIANFS..FTTIKKMIYQLFEKHIEltapvLLTMAKKEQKSQC--lsee................................................
G1LLV1_AILME/27-234              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTRLLKNRILKK--kekrkkererk.........................................
F2SR84_TRIRC/163-402             .......................k-AQSL.PILDNL......................STQILSFIAR...TSf..qDLTALVSEPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TNKP....FLSASELG.............FTEASQV--EV..IRKANLASF.V...FSLF..GTQE..IGF...AELHDNFLDIFVPEGG.................................................RLLKSQAALFLELKTQTFIASMN.............................................-NPARPKVEILY.ELFPDNLGL.SLLARRPG............tRHPAP..SETDFVKRASSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....SLTTQTKRLNKTR--spts................................................
G3URU7_MELGA/36-235              .....................aad-----.WVLEFS......................CCCLCRHFVE...--....-----------................ECGAEFGRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECQF..ENDT.rISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YNLLLSKVKSYVELFLKengtnFLLQAATKQVESKG-ge..................................................
F6XW21_MONDO/17-218              .................adslacg-----.WMLDFF......................CLNLCQAFCE...--....-----------................DDIEEFKRN.RNIAEAIIHGL.....S.RLTA....--------.............HHLRTIYVCQF..LTRIVEGKT.L...DAQF..ESDA.rLTP...LESALIIWNKIRKEKE.................................................---ILHDQIHDLLEIQAVAVCME.............................................KASHKEAEGVFE.RIFGDTEDN.--------.............-----..---------NPLKMKLLMVIN.KKDPNHVFFQRFT..YKCMIDRIKIYANQVLTeksssFLMKAALKVVESKK-dee.................................................
F7FBA4_MONDO/22-222              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................GRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TISRLLRIMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLETIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLGIIR.ERNITHPVIQNFS..YEIFQQKMLRFLESHMDdaepyLLTMAKRALKSESA-sts.................................................
G3USR1_MELGA/23-222              .....................aad-----.WVLEFS......................CCCLCRHFVE...--....-----------................ECGAEFGRW.RDVAQAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECQF..ENDT.rISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YNLLLSKVKSYVELFLKengtnFLLQAATKQVESKG-ge..................................................
A7MD83_DANRE/29-224              ....................vvqs-----.WIIDYY......................FATLCRHFRE...--....-----------................RSSVEFRKE.LKLFEGLVDEL.....E.SHSS....--------.............----QRTVCCF..LARVMDGEN.L...DVRY..DHVA.rITP...LMSAVPVWESLKDFSD.................................................--PTLHGKIQTLLMVQSVAVCVK.............................................KGYDKLAKETLQ.WLEEQTDVP.--------.............-----..---------EKLQRKLATIVN.KKDAYDQILMNFS..FDELMETIDTFLEAFNQqyasvFLLEAASKVVQARH-ers.................................................
G7PC12_MACFA/72-269              .....................aag-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFRRT.RNSAEAIIHGL.....S.SLTA....--------.............YQLRTIYICQF..LTRIAAGKT.L...DAQF..ENDE.rITP...LESALMIWGSIEKEHD.................................................---KLHEEIQNLIKIQAIAVCME.............................................NGNFKEAEEVFE.RIFGDPNSY.--------.............-----..---------MPFKSKLLMIIS.QKDTFHSFFQHFS..YNHMMEKIKSYVNYVLSeksstFLMKAAAKVVESKR-trt.................................................
H0WSZ2_OTOGA/68-269              ...................avatg-----.WMLDFL......................CLSLCRAFRD...--....-----------................GRSEDFQRT.RDSAEAIIHGL.....P.SLTA....--------.............YQLKTVYICQF..LTRIAAGKT.L...DALF..EFDK.fIQR...CNSILIVGDSLRVQET.................................................RLHGLH-LLDNLIFFFAIAVCME.............................................NGNFKEAEEVFE.RIFDDPDSY.--------.............-----..---------TPLKRKLLVIIS.QKDTYHSIFQHFS..FNHMMDKIKTYVNDVVNeksstFLMKAAAKVVESKR-trt.................................................
F6RQ75_HORSE/2-178               ......................ti-----.------......................----------...--....-----------................------RQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdtepyLLTMAKKALKSES--aas.................................................
H0Y0S5_OTOGA/67-257              ...................avatg-----.WMLNFL......................CLSLL-AFRD...--....-----------................GCSEEFHRN.RST-EAIIHGL.....P.SLTA....--------.............YQLKTVYICQF..LTRIAAGKT.L...DAQF..DTYE..---...--SALMIWDSVEKEHD.................................................---KRHEEIQNLIKIQAIAVCME.............................................NGNFKEAEKVFE.RIFDDPNSY.--------.............-----..---------TPLKRKLLTIIS.QKDTYHSLFQKIS..FNHMMEK-KTYVNDIVNeksstFLMKTAAKVVESKR-trt.................................................
C5JEE9_AJEDS/186-424             ........................MIQSL.PILDNL......................STQILTLLAQ...SSy..qDLTSIVSEPTS................ESGQAYSTM.RSLFDHTKNVY.....T.SKGS....FLSPRELD.............LTEPNQV--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQYFLEIFVPEGN.................................................RLLKVQGALFLELKTQAYIAAMS.............................................-SGKRSRTELLY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRAYSRRDILLNEVN.NPEAAAALPEKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKSSK---grls................................................
Q802C2_CHICK/25-224              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAHAVSNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENNT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
G3WRI4_SARHA/25-228              .................adslacg-----.WMLDFF......................CLNLCQAFCE...--....-----------................DDIEEFKRN.RNIAEAIIHGL.....T.RLTA....--------.............HHLRTIYVCQF..LTRIVEGKT.L...DAQF..ESDA.rLTP...LESALMIWNKIRKEKE.................................................---PLHDQIRDLLEIQAVAVCME.............................................KASYKEAEGVFE.RIFGDTEAL.SFL-----.............-----..----------PLKMKLLMIIN.KKDPYHPFFQRFT..YKCMIDRVKIYANQVLTeksssFLMKAALKVVESKK-dee.................................................
G8BVU3_TETPH/27-328              ....................sltv----L.ATLENI......................STILLRYILLntlTP...hSIVNLIQNQDLnlqvdd...nidsggvLDNTTFQKL.LSLFKELMCLF.....E.NRSPdnsfTITVHDVTgglwvpnqsiahiIKDDRQFIVKT..VKQINLLKY.L...LIAL..GCYD.dLGI...DVLENMFFDVFCSQSYfnkrtslfknknyea...................pvnnkkdiladdqtrKFLKTHGVLLLELKTQALVLTLDeir......................................ngssSITKNRMSQVLE.KIFPNDEMN.---VR--K.............KEMSP..AESEFIEKCIHRKNSLF----.KFTNFETLTEHYS..WKEFIKSLLSFCNKNIG.....TIILGRAGRGVNP--lfd.................................................
F1NCJ0_CHICK/37-236              .....................aad-----.WVLEFS......................CCCLCRYFVE...--....-----------................ECEAEFRRW.RDVAQAISNGF.....S.KVTT....--------.............HQKKMVYLCQL..LIRIAEGKR.L...ECHF..ENDT.tISP...LESALSFWTLLEREES.................................................KLNTLHEEIRRLIQIQVVAVYME.............................................KGYYKEAAEVLE.RLFTDSESH.--------.............-----..---------KPLRMKLAAIVK.SKDPYVPLLQSFS..YSLLLSKVKSYVKLFLKenrtnFLLQAATKQVESE--gge.................................................
F6W9R8_CALJA/1-115               ......................mi-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...----..----..---...-----------KTEFT.................................................LTEAVVESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
D4B3M3_ARTBC/171-410             .......................k-AQSL.PILDNL......................STQILSFIAR...TSf..qDLTALVSEPQS................ENAQSYSTL.RSLFDHTKKVY.....T.TNKP....FLSASELG.............LTEASQV--EV..IRKANLASF.V...FSLF..GTQE..IGF...AELHDNFLDIFVPEGG.................................................RLLKSQAALFLDLKTQTFIASMN.............................................-NPARPKVEILY.ELFPDNLGL.SLLARRPG............tRHPAP..SETDFVKRASSRRDILLGEIN.NPDSIHTLPEKYL..WQDFLRDISVYVSKNID.....SLTTQTKRLNKTR--spts................................................
F0UMU9_AJEC8/175-413             .......................m-TKSL.PILDNL......................SSQILTLLAQ...SSy..qDLTSIVSEPNS................ECGQAYSTM.RSLFNHTKNVY.....S.SKGS....FLSPRELD.............LTEPSQM--DI..IRKANMASF.V...SSIF..GSQE..IGF...SELDQHFLEIFVPEGS.................................................RLLKVQGALFLELKTQAYIAAMN.............................................-SGKRSRTEILY.ELFPDDLEE.RLLSRRPG............tKQLAP..SETDFVKRVFSRRDILLNEVN.NPEAASALPQKYR..WEDFLRDLSSYVSKNFE.....AISHQQTKKPSK---grps................................................
C7YWH2_NECH7/143-368             ....................asrh-----.-ALGNM......................ALSILLLFSQ...SF...dDSIKPIRDVES................QHAKAFRNL.QTSFEQTKQIY.....-.STSA....ILSADELE.............LQDHESR--TI..LDLANLAQF.A...IWLL..QTTP..-SY...SNAHQNFHSIFRGQVS.................................................DLGSDALDLYLSIKTQVAIDALA............................................tKTPEQQSGPILD.DAIISGMED.KLRGLHHN.............SDLTP..ADREFISSVRSMKNAIQ--GE.AQPDTASLREKYK..VDDLLAQVATCVKTRLA.....L--------------msdlgsrl............................................
G0RYG2_CHATD/286-527             ...................vmrsm---SL.PVLGNI......................AVQILLRLSQ...QSr..aETDSLLSDAKS................DFRKSYDMV.AEAFRATRRIF.....-.SDTP....LLSADELE.............ISDSEDR--ET..IRISNLAAT.A...ASAF..VAHD..VPL...GDVHEAFFTIFIPEDG.................................................EYKDSLSDLLVCIKTRLFLDEAS............................................rAEQGQSQTNPLD.TFFPLNFDE.TLKQRSGD.............VLLTP..DEQQLVNKLKERRDLLTTIST.DEVVKKSMEEQAS..MDKYINALSNFLQGHLA.....VVVDYAEKYGVNIP-lne.................................................
Q3V252_MOUSE/158-229             ..................eiknli-----.------......................----------...--....-----------................---------.-----------.....-.----....--------.............-----------..---------.-...----..----..---...----------------.................................................-----------------------.............................................------------.---------.--------.............-----..-------KIQPLERKLLKIIS.QKDVFHSLFQHFS..YSCMMEKIQSYVGDVLSeksstFLMKAATKVVENEK-art.................................................
H0WXM7_OTOGA/16-216              .......................v-NR--.WVLKFY......................FHEALRAFRG...--....-----------................SRYGDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTEAVIESSRKLVKEAAVIICIK.............................................NKEFEKASKILK.KHMSKDPTT.--------.............-----..---------QKLRNDLLNIIR.EKNLAHPVIQNFS..YETFQQKMLRFLESHLDdaepyLLTMAKKALKSES--aass................................................
B1H237_RAT/91-291                .......................v-NR--.WVLKFY......................FHEALRAFRS...--....-----------................SRYRDFRQI.RDIMQALLVRP.....L.GKEH....--------.............TVSRLLRVMQC..LSRIEEGEN.L...DCSF..DMEA.eLTP...LESAINVLEMIKTEFT.................................................LTDSMVESSRRLVKEAAVIICIK.............................................NKEFEKASKILK.KYMSKDPTT.--------.............-----..---------QKVRTDLLNIIR.EKNLAHPVIQNFS..YEIFQQKMLRFLESHLDdtepyLLTMAKKALRSE---saass...............................................
#=GC SS_cons                     .....................HHH-HH--.HHHHHH......................HHHHHHHHHC...--....-----------................T-HHHHHHH.HHHHHHHCCT-.....S.CCTH....--------.............HHHHHHHHHHH..HHHHCTTT-.T...TEE-..SSST.TS-H...HHHHHHHHCCCCCCTC.................................................--HHHHHHHHHHHHHHHHHHHHH.............................................TT-HHHHHHHHH.HHTSSSSTG.--------.............-----..---------CCCHHHHHHHHH.CTCCTCHHHCCT-..HHHHHHHHHHHHHCCCHHHTTCHHHHHHHHCCCTT--XXXX................................................
#=GC seq_cons                    .......................s.......hL-.h......................shpllphhtp....................................spspsFpph.pslhctlhphh.......spss.........................hpt+phhlhph..Lp+ls.uph.L...sspF..sspp..ls....hEss.thhchhpsEts.................................................hh.csppplhh.lKpQAhlsshc.............................................ptphcptp-lLc.clFscs.sp......................................pph+ppLl..lp.pcsshcslhppas..apphhcclhsalppphs.....hLhhttpthhpp...stp.................................................
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