GenomeNet

Database: Pfam
Entry: PF09191
LinkDB: PF09191
Original site: PF09191 
#=GF ID   CD4-extracel
#=GF AC   PF09191.9
#=GF DE   CD4, extracellular
#=GF AU   Sammut SJ
#=GF SE   pdb_1cid
#=GF GA   26.00 26.00;
#=GF TC   26.20 26.00;
#=GF NC   25.90 25.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   CD4
#=GF RN   [1]
#=GF RM   8493535
#=GF RT   Crystal structure of domains 3 and 4 of rat CD4: relation to the
#=GF RT   NH2-terminal domains. 
#=GF RA   Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF,
#=GF RA   Barclay AN; 
#=GF RL   Science. 1993;260:979-983.
#=GF DR   INTERPRO; IPR015274;
#=GF DR   SCOP; 1cid; fa;
#=GF CC   Members of this family adopt an immunoglobulin-like
#=GF CC   beta-sandwich, with seven strands in 2 beta sheets, in a Greek
#=GF CC   key topology. They are predominantly found in the extracellular
#=GF CC   portion of CD4 proteins, where they enable interaction with
#=GF CC   major histocompatibility complex class II antigens [1].
#=GF SQ   74
#=GS A0A091UGP9_PHORB/139-252  AC A0A091UGP9.1
#=GS F1SLT4_PIG/208-315        AC F1SLT4.1
#=GS A0A0Q3URE4_AMAAE/218-331  AC A0A0Q3URE4.1
#=GS A7YY52_BOVIN/206-313      AC A7YY52.1
#=GS G3ULS8_LOXAF/226-330      AC G3ULS8.1
#=GS H2NG98_PONAB/162-272      AC H2NG98.1
#=GS F6XGD3_MACMU/206-316      AC F6XGD3.1
#=GS F6Y6X8_HORSE/209-315      AC F6Y6X8.1
#=GS CD4_HUMAN/206-316         AC P01730.1
#=GS CD4_HUMAN/206-316         DR PDB; 1WIP B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIO A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIO B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIQ A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 3T0E E; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIQ B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIP A; 181-291;
#=GS M3W1W4_FELCA/225-331      AC M3W1W4.1
#=GS G3QL31_GORGO/206-316      AC G3QL31.1
#=GS A0A096MWA4_PAPAN/206-316  AC A0A096MWA4.1
#=GS F7ILX9_CALJA/138-248      AC F7ILX9.1
#=GS F1MJK4_BOVIN/206-313      AC F1MJK4.2
#=GS A0A093FFP9_GAVST/139-251  AC A0A093FFP9.1
#=GS F7AB77_MONDO/124-230      AC F7AB77.2
#=GS G1T4B9_RABIT/211-317      AC G1T4B9.1
#=GS G3UL65_LOXAF/207-311      AC G3UL65.1
#=GS G3TZC2_LOXAF/215-319      AC G3TZC2.1
#=GS CD4_MACMU/206-316         AC P16003.2
#=GS G3GUN9_CRIGR/207-313      AC G3GUN9.1
#=GS F6WG07_ORNAN/260-367      AC F6WG07.2
#=GS CD4_PANTR/206-316         AC P16004.1
#=GS A0A091PM83_HALAL/138-249  AC A0A091PM83.1
#=GS CD4_RAT/209-315           AC P05540.1
#=GS CD4_RAT/209-315           DR PDB; 1CID A; 1-106;
#=GS G3U7C0_LOXAF/209-313      AC G3U7C0.1
#=GS H2RB07_PANTR/206-316      AC H2RB07.1
#=GS K7G8F0_PELSI/204-311      AC K7G8F0.1
#=GS I6LI22_MUSPF/214-319      AC I6LI22.1
#=GS G3UBY8_LOXAF/206-310      AC G3UBY8.1
#=GS I3MTU1_ICTTR/209-315      AC I3MTU1.1
#=GS G5CAQ9_HETGA/193-300      AC G5CAQ9.1
#=GS W5P8J4_SHEEP/206-313      AC W5P8J4.1
#=GS I3L556_PIG/132-222        AC I3L556.1
#=GS A0A091VVS5_OPIHO/140-252  AC A0A091VVS5.1
#=GS L8Y3X9_TUPCH/229-335      AC L8Y3X9.1
#=GS G7PJN3_MACFA/206-316      AC G7PJN3.1
#=GS G1QXL1_NOMLE/206-316      AC G1QXL1.1
#=GS CD4_RABIT/211-317         AC P46630.1
#=GS I3NES8_ICTTR/204-310      AC I3NES8.1
#=GS A0A099ZZE9_CHAVO/140-252  AC A0A099ZZE9.1
#=GS A0A087RHA1_APTFO/140-252  AC A0A087RHA1.1
#=GS H0XBR4_OTOGA/127-233      AC H0XBR4.1
#=GS A0A091UPT0_NIPNI/140-252  AC A0A091UPT0.1
#=GS M7B2Z9_CHEMY/145-256      AC M7B2Z9.1
#=GS A0A0D9RD08_CHLSB/308-418  AC A0A0D9RD08.1
#=GS A0A093S7H6_PHACA/140-252  AC A0A093S7H6.1
#=GS A0A091J8V4_9AVES/138-251  AC A0A091J8V4.1
#=GS A0A091PV80_LEPDC/140-252  AC A0A091PV80.1
#=GS L5KFG2_PTEAL/215-241      AC L5KFG2.1
#=GS S9XJK8_CAMFR/261-370      AC S9XJK8.1
#=GS A0A091CQ95_FUKDA/597-704  AC A0A091CQ95.1
#=GS A0A093CSY3_TAUER/139-252  AC A0A093CSY3.1
#=GS A0A151MCU8_ALLMI/287-398  AC A0A151MCU8.1
#=GS G3TWZ4_LOXAF/209-313      AC G3TWZ4.1
#=GS A0A096N677_PAPAN/206-316  AC A0A096N677.1
#=GS A0A091RAA2_MERNU/139-252  AC A0A091RAA2.1
#=GS F7I777_CALJA/1-43         AC F7I777.1
#=GS G3UCG3_LOXAF/209-313      AC G3UCG3.1
#=GS H0VL66_CAVPO/208-317      AC H0VL66.1
#=GS G1QAX4_MYOLU/209-315      AC G1QAX4.1
#=GS CD4_CANLF/214-320         AC P33705.1
#=GS F1SLT5_PIG/208-315        AC F1SLT5.1
#=GS A0A091I8Q3_CALAN/139-250  AC A0A091I8Q3.1
#=GS G1Q929_MYOLU/205-311      AC G1Q929.1
#=GS G3WTA4_SARHA/233-343      AC G3WTA4.1
#=GS A0A091SDT1_9GRUI/138-252  AC A0A091SDT1.1
#=GS CD4_MOUSE/210-316         AC P06332.1
#=GS W5P8J5_SHEEP/206-313      AC W5P8J5.1
#=GS S7N841_MYOBR/214-320      AC S7N841.1
#=GS G1M645_AILME/165-270      AC G1M645.1
#=GS L5M931_MYODS/214-318      AC L5M931.1
#=GS A0A091KB69_COLST/139-252  AC A0A091KB69.1
#=GS A0A091MIH9_9PASS/139-247  AC A0A091MIH9.1
A0A091UGP9_PHORB/139-252             dler-----KYATVDSTVTLSWCLNFQN....IKWke..gfAAQLNW.K.QQKNATTHELLDFNITA.Q..EK.Q.H.KtKKSSRFRFEI...LE...R..GPegiIAVKLPKVHFNHSGQYQCQLVYKG..R..YTQKEIELVV.
F1SLT4_PIG/208-315                   ....KVPSTVYVKEGDQVVLSFPLTFEA....ESL......SGELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
A0A0Q3URE4_AMAAE/218-331             nler-----KYVTVGSAVILSWLLNFQKikwkEDF......TGQLNW.K.QQGSATTHELFAFSITA.RgeQQ.E.I.K.K-SSHFGSEI...PE...S..XPdgtIQVKLPKVHFNHSGQYKCELAYKG..R..HVQSRIDLVV.
A7YY52_BOVIN/206-313                 ....KAPETVYVKEGEQAEFSFPLTFEY....ENL......SGELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
G3ULS8_LOXAF/226-330                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
H2NG98_PONAB/162-272                 ....KASSIVYKKEGEKVEFSFPLTFTV....ERLm....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.QVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLRQEVNLVV.
F6XGD3_MACMU/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
F6Y6X8_HORSE/209-315                 ....KVSRTVYAKEGTQAEFSFPLTFAD....ENL......SGELQW.Q.AEGASSQQKWISFSSDN.R..KV.S.V.T.GVSSHLKLQV...EE...M..LP...LRFKLLQALPKHAGSGKLRLFLAK..G..ELQQEVNLVV.
CD4_HUMAN/206-316                    ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
#=GR CD4_HUMAN/206-316         SS    ....-SEEEEEEETCS-EEEE-------....-SS-....EEEEEEE.E.ESSSSS---EEEEEEBS.S..BE.E.E.E.EEETSST-B-...-S...S..SS...-EEEESSB-GGG-EEEEEEEEBTTTT-..-EEEEEEEEE.
M3W1W4_FELCA/225-331                 ....KVSNTVYAKEGEQVEFSFPLNFED....ENL......MGNLRW.K.AEGAPSSLLWISFTLKN.K..QL.S.V.K.EVDPYSKLQM...MD...S..LP...LRFTLPNVLSRYAGSGNLTLVLDK..G..QLQQEVKLVV.
G3QL31_GORGO/206-316                 ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A096MWA4_PAPAN/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.WVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
F7ILX9_CALJA/138-248                 ...q-ASSTVYKKEGEQVEFSFPLAFAA....EQLt....gSGELCW.Q.AERASSSKSWITFNLTN.Q..EV.C.V.K.LVTQDPKLRM...GK...K..LP...FHLTLPQALPQYAGSGNFTLALKGktG..KLHQEVKLVV.
F1MJK4_BOVIN/206-313                 ....KAPETVYVKEGEQAEFSFPLTFEY....ENL......SGELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
A0A093FFP9_GAVST/139-251             lerk------YAAVDSTVILSWSLNFQK....IKWke..gfTGQLSW.K.QQENATTHELLDFNVTA.R..GEqH.R.T.KKGSHFRFEI...LE...N..KPestIEVKLPKVHFNHSGQYQCQLAYNG..R..SVQSKIELVV.
F7AB77_MONDO/124-230                 .pyq----RYYKIAGKDAEFNFPLNLGE....QDLnr.mvpNGELTW.H.GEGAAS-QRLAKFSWKD.D..SL.T.L.E.D---KFKFKL...SK...G..RP...ITLSLSPVLLHHAGSGVFSLMLPS..G..TVKQKVDLVV.
G1T4B9_RABIT/211-317                 ....KASATVYKKEGEQVEFSFPLNFED....ESL......SGELMW.Q.ADGASSAQSWVSFSLED.R..KV.S.V.Q.KILPDLKIQM...SK...G..LP...LSLTLPQALHRYAGSGNLSLTLDK..G..KLHQQVSLVM.
G3UL65_LOXAF/207-311                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
G3TZC2_LOXAF/215-319                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
CD4_MACMU/206-316                    ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G3GUN9_CRIGR/207-313                 ...n-SSTIVYKKEGEPAEFSFPLTFQD....ENL......QGELMW.R.AEKASSPGPWVTFSLEN.K..KV.A.V.L.KSWGTAKLQM...KE...E..LP...LHLKIHQVSLDNAGSGNLTLTLAK..G..KLRQEVNLVV.
F6WG07_ORNAN/260-367                 ..kp--SEIFYGVVNDSLTLTFTLNFKP....SEK......NWEMFW.N.QAGPFN-LSTALTDLKE.Q..QN.R.E.G.KSVKTGFTEK...SS...D..HR...LHFQVKNLQAQHAGSGFFRLYIEK..LkwKLEQKVELVV.
CD4_PANTR/206-316                    ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A091PM83_HALAL/138-249             dler-----KYATADSTVILSWHLNFRK....IKWke..gfTGQLNW.K.QQESATAHELLDFNVTA.R..GE.Q.H.EtKKSSRFQYEI...RK..pE..ST...IELKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
CD4_RAT/209-315                      ...s-TSITAYKSEGESAEFSFPLNLGE....ESL......QGELRW.K.AEKAPSSQSWITFSLKN.Q..KV.S.V.Q.KSTSNPKFQL...SE...T..LP...LTLQIPQVSLQFAGSGNLTLTLDR..G..ILYQEVNLVV.
#=GR CD4_RAT/209-315           SS    ...X----EEEEETTS-EEEE-----SS....--E......EEEEEE.E.ESS---S--EEEEEEET.T..EE.E.E.E.S---SS--EE...-S...B..TT...-EEEE-S--GGG-EEEEEEEE-SS..S..EEEEEEEEEE.
G3U7C0_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
H2RB07_PANTR/206-316                 ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
K7G8F0_PELSI/204-311                 ..nq---ETVYTAVNSSANFSYQMNNIL....QEMtklkniRGALMW.K.SEGESEYREKFNFNFSS.G..SL.R.L.P.KQMANLQF--...--...T..AN...LQVKMPKVQFQDAGWYRCQLTLKQ..G..SVKKDIHLVV.
I6LI22_MUSPF/214-319                 ....KVSNTVYSREGEQVKFSFPLNFEI....EKL......SGELRW.R.TEGAPSSLLWSSFTLEN.K..KL.F.V.K.EVHH-PRLQL...KE...T..LP...LSFILPQASSQYAGSGTLTLSLAK..G..TLQQEVNLVV.
G3UBY8_LOXAF/206-310                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
I3MTU1_ICTTR/209-315                 ..et--LNTVYKKVGEQVELSFPLNIGD....EDL......RGELKW.Q.AERSSSSKTWFTFSLKN.K..QF.S.V.Q.KVIQDPKLQV...AE...N..LP...LRFTLSHALPQYAGSGELTLTLDK..G..KLQKNVKLVL.
G5CAQ9_HETGA/193-300                 ...k-SPRTAYKKEGEALELSFPLTFDD....EAH......LGELSW.R.ADRASSSQVWISFSVEN.R..KV.S.V.Q.MAALDPQLQM...AE...K..TP...LRLILSEALLQHAGSGNLTLTLAG..D.lKLHQEVNLVV.
W5P8J4_SHEEP/206-313                 ....KAPETVYVKEGEQAEFSFPLTFED....ENL......SGELTWqQ.ANKDSSSQSWVTFTLRN.R..EV.K.V.N.KTHKDVKLHM...GE...R..LP...LRLTLQRTLPQYAGSGTLTLDLTK..G..KLHQKVNLVV.
I3L556_PIG/132-222                   ....KVPSTVYVKEGDQVVLSFPLTFEA....ESL......SGELMW.R.--------QWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYV--------LPE..G..RLHREVNLVV.
A0A091VVS5_OPIHO/140-252             .fer-----QYAAVDSTVTLSWHLNFQK....IKWke..yfTGQLNW.K.QQETAAAHELLDFNITE.R..EG.Q.H.EtKKSSHFRFEI...PE...S..KPkstIAVKLHKIHLNHSGQYQCQLVYNR..R..SVTSKIELVV.
L8Y3X9_TUPCH/229-335                 ....KASMTLYKKEGERVDLSFPLTFED....EHL......RGELRW.Q.AERPPSSESWVSFSVQA.K..EV.T.V.Q.GSLPDLKLQM...AK...S..LP...LSITLPQAHLRHAGSGKLTLTLGK..G..QLQQDVNLVV.
G7PJN3_MACFA/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G1QXL1_NOMLE/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTV....EKLt....gSGELCW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...DK...K..LP...LHLTLPQALPQYAGSGNLTLDLEAktG..KLRQEVNLVV.
CD4_RABIT/211-317                    ....KASATVYKKEGEQVEFSFPLNFED....ESL......SGELMW.Q.VDGASSAQSWVSFSLED.R..KV.S.V.Q.KILPDLKIQM...SK...G..LP...LSLTLPQALHRYAGSGNLSLTLDK..G..KLHQQVSLVM.
I3NES8_ICTTR/204-310                 ..et--LNTVYKKVGEQVELSFPLNIGD....EDL......RGELKW.Q.AERSSSSKTWFTFSLKN.K..QF.S.V.Q.KVIQDPKLQV...AE...N..LP...LRFTLSHALPQYAGSGELTLTLDK..G..KLQKNVKLVL.
A0A099ZZE9_CHAVO/140-252             lerk------YATVDSTVILSWHLNFQK....IKWkk..gfTGQLKW.K.QQESTTTHELLDFNVTA.R..GE.K.HeT.KKSSHFRFEI...PE...S..KPentINVKLPKVHFNHSGQYQCQLAYNG..R..DTHSRIELVV.
A0A087RHA1_APTFO/140-252             ferk------YATVDSTVVLSWHLNFQK....IKWke..gfTGQLNW.K.QHESAVAHELLDFNVTAgG..KQ.H.E.T.KKSSHFQFEIpgsKP...K..ST...IEVKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
H0XBR4_OTOGA/127-233                 ...g-ASSAIYKKEGEQVEFSFPLTFKE....ERL......EGELRW.Q.AEKASSSKPWVTFFLEN.N..KV.S.V.K.WITQDPKLQM...EE...T..LP...LRFTLPQALPQYAGSGNLTLVITS..R..KLQQEVKLVV.
A0A091UPT0_NIPNI/140-252             ferk------YATVDSTVILSWRLNFQK....IDWke..gfTGQLNW.K.QQENANAHELLDFNVTA.R.gKQ.H.E.T.KKSSRFRFEI...PE...S..KPestIEVKLPKVHFNHSGQYQCQLAYNG..R..HVQSKIELVV.
M7B2Z9_CHEMY/145-256                 ..nq---ETLYKAVNSTVSFSYSLSTDL....QKIrkleyiTGGLEW.K.SMADNKYREKFNFSVTS.K..EL.P.L.F.KQIANMQFTW...KL...I..NH...LEVKLPKVQFKDAGWYQCQLRVSR..G..RVEKAIHLVV.
A0A0D9RD08_CHLSB/308-418             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.QVTQDPKLQM...GK...K..LP...LNLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A093S7H6_PHACA/140-252             ferk------YATVDSSVILSWHLNIQK....IKWek..glTGQLYW.K.KQENETIHELLDFNVTA.Q.gQL.H.G.T.KKSSHFQFEI...PE...S..KPgstIEVKLPTVHFDHAGQYQCQLAYKG..R..NTQRKIELVV.
A0A091J8V4_9AVES/138-251             dler-----KYATVGSTVILSWHLNFQK....IKWke..gfTGQLNW.K.QQESATPHELLDFNVTA.R..GE.K.HeT.KKSSHFWFEI...PE...S..KPksaIEVKLPKVHFNHSGQYQCQLAYNR..R..SVQSKIELVV.
A0A091PV80_LEPDC/140-252             lerk------YATVDSPVILSWHLNFQK....IKWke..gfTGQLTW.K.QQENATSHELLDFNVTA.R..GE.Q.HeT.KKSRRFQFEI...PE...S..KPestIEVKLPKVYFNHSGQYQCQLVYNG..R..HMQSKIELVV.
L5KFG2_PTEAL/215-241                 ....KVSNTVYAKEGEKVELSFPLTFED....ENL......------.-.-----------------.-..--.-.-.-.----------...--...-..--...------------------------..-..----------.
S9XJK8_CAMFR/261-370                 ....KVSSTVYAKEREQAVFSFPLTFED....ESL......SGELTWwP.AKRASSSESWITFSLKN.M..KV.S.V.E.TVRKDLKLQM...RE...K..LP...LHLTLPQALPQCAGSGKLTLVLTQ..GnrKLHQEVNLVV.
A0A091CQ95_FUKDA/597-704             ....KSSSTAYRKEGEALELSFPLTFED....EAL......VGELSW.R.ADRALSSQVWVSFSVEN.R..KV.T.V.Q.AAAQDPKLQV...AE...K..TP...LCLTLSKALLQHAGSGNLTLTLAG..G.lKLCQEVHLVV.
A0A093CSY3_TAUER/139-252             dler-----KYATADSTVILSWHLNFQK....IKWka..gfTGQLNW.K.QQESATAHELLDFNVTS.R..GE.QhE.T.KKSSRFRFEI...PE...R..KPdstIAVKLPKVHFNHSGQYQCQLAYHQ..R..HAQSKIELVV.
A0A151MCU8_ALLMI/287-398             ...e--SEIQYAAVNTTASFSYSLNLQE....VRWtg..sfKGRLDW.K.AKTNDKYQEIMNFNFTN.Q..RL.T.L.P.KQIKHFGFKG...DE...KsfSK...LDVELSKVLFEDAGWYQCRVTFDF..G..HVETAIHLVV.
G3TWZ4_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A096N677_PAPAN/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSGELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.WVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLV-e
A0A091RAA2_MERNU/139-252             ..ds---ERKYAAVDSTVVLSWDLNFQE....IKWkk..gfTGQLSW.K.QQESATAHELLDFNVTE.Q..RK.Q.HeM.KKSSRFWFEI...PE...S..KPkstIQVKLPKVHFNHSGQYQCQLEYDR..A..YTQNKIELV-a
F7I777_CALJA/1-43                    ....------------------------....---......------.-.-----------------.-..--.-.-.-.---------M...GK...K..LP...FHLTLPQALPQYAGSGNFTLALKGktG..KLHQEVKLVV.
G3UCG3_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TGELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
H0VL66_CAVPO/208-317                 ..qi--PNPFYKKEKESLEMCFPLTFNN....EDLp....fTGELIW.R.ADKASSSHSWITFSVAN.Q..RV.S.V.Q.NDNQDPKLQM...AE...K..TP...LCLTLSSVLLQHAGSGNLTLTLDG..G.qRLSQEVKLVV.
G1QAX4_MYOLU/209-315                 ...d-VSDTVYTKVGEPVEFSFPLTFED....ENL......VGELRW.Q.EEGTSSPQPWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASLQDVGSGHLTLNLSQ..G..QLHQKVNLAV.
CD4_CANLF/214-320                    ....KVSNTFYAREGDQVEFSFPLSFED....ENL......VGELRW.Q.AQGASSSLLWISFTLEN.R..KL.S.M.K.EAHAPLKLQM...KE...S..LP...LRFTLPQVLSRYAGSGILTLNLAK..G..TLYQEVNLVV.
F1SLT5_PIG/208-315                   ....KVPSTVYVKEGDQVVLSFPLTFEA....ESL......SGELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
A0A091I8Q3_CALAN/139-250             lvrk------YATVDSSVTLSWCLNFQK....IKWke..gfTGKLNL.K.QEENASAYELLDFNVTA.Q..KQ.H.E.T.KKSRHFQFEI...PE...R..KPestIEVKLPKVHFNHSGQYECQLAYNG..R..YTQSNIELVV.
G1Q929_MYOLU/205-311                 ...d-VSDTVYTKVGEPVEFSFPLTFED....ENL......VGELRW.Q.EEGTSSPQPWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASLQDVGSGHLTLNLSQ..G..QLHQKVNLAV.
G3WTA4_SARHA/233-343                 ..sp--SQTIYGMTGKTVQFSFPLNLNE....QELnk.enpKGEFTW.Q.VEGVASPQQPAKYSWKD.N..NL.T.P.K.NGIPNFKAE-...KS...N..FA...ITFTLSPVLPQHAGSGVFLLKFSS..G..DLKQKVKLVV.
A0A091SDT1_9GRUI/138-252             ..pd--SERKYATVGSTVILSWHLNFQK....IKWer..gfTGQLNW.K.QQANATTHKLLDFNVTA.Q..RE.Q.H.KtKKRSHFWFEI...LEskpE..SP...IEVKLPKVHFNSSGQYQCQLAYDT..R..STQSEIELVV.
CD4_MOUSE/210-316                    ..st--AITAYKSEGESAEFSFPLNFAE....ENG......WGELMW.K.AEKDSFFQPWISFSIKN.K..EV.S.V.Q.KSTKDLKLQL...KE...T..LP...LTLKIPQVSLQFAGSGNLTLTLDK..G..TLHQEVNLVV.
W5P8J5_SHEEP/206-313                 ....KAPETVYVKEGEQAEFSFPLTFED....ENL......SGELTWqQ.ANKDSSSQSWVTFTLRN.R..EV.K.V.N.KTHKDVKLHM...GE...R..LP...LRLTLQRTLPQYAGSGTLTLDLTK..G..KLHQKVNLVV.
S7N841_MYOBR/214-320                 ...n-VSDTVYTKVGEPVEFSFPLTFED....ENL......VGELRW.R.EEGTSSLQSWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASIQDVGSGHLTLNLSR..G..QLHQKVNLAV.
G1M645_AILME/165-270                 ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SGELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFILSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
L5M931_MYODS/214-318                 ...n-ISDTVYTKVGEPVEFSFPLTFDD....ENL......VGELRW.Q.EEGTSSPRPWITFSLEN.R..KV.T.V.K.KFQK--KIQL...KE...T..LP...LTFSLPQASLQDVGSGLLTLNLSQ..G..QLHQKVNLAV.
A0A091KB69_COLST/139-252             ..dl---ETKYATVDSPVILSWHLNFQE....IKWkg..gfTGKLIW.K.QQESATFQELLHFSITA.Q.gEL.N.E.T.KKSSRFNFEI...PQ...N..KPkstIEIKLLKVHFSQSGQYQCELAYNG..R..QVQSKIELVV.
A0A091MIH9_9PASS/139-247             lerk------YAAVDSTIILSWHLNFQK....IKWke..afTGQLKW.K.EQKSTNTHELLDFNMTA.R..GQ.K.Q.E.TKKSSHILFE...TP...E..ST...IGVKLPKVHFNHSGQYQCQLAYKG..R..HVQSKIELVV.
#=GC SS_cons                         ...X-SEEEEEEETCS-EEEE-----SS....-SC.....EEEEEEE.E.ESSSSSS--EEEEEEET.T..EE.E.E.E.CEETSST-EE...-S...C..TT...-EEEESSB-GGG-EEEEEEEEBTTTTS..EEEEEEEEEE.
#=GC seq_cons                        .....sspTlYtKpG-pVcFSFPLsFpc....ccL......oGELpW.p.sctuoSsppWloFslps.+..cl.o.l.p.+hppc.+lph...sE...p..LP...LploLPpsh.QaAGSGpLTLsLsp..G..+LpQcVpLVV.
//
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