#=GF ID   Helicase_Sgs1
#=GF AC   PF11408.12
#=GF DE   Sgs1 RecQ helicase
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   pdb_1d8b
#=GF GA   22.20 22.20;
#=GF TC   22.20 22.20;
#=GF NC   22.10 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0426
#=GF RN   [1]
#=GF RM   10647186
#=GF RT   The three-dimensional structure of the HRDC domain and
#=GF RT   implications for the Werner and Bloom syndrome proteins. 
#=GF RA   Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M,
#=GF RA   Bork P, Sattler M; 
#=GF RL   Structure. 1999;7:1557-1566.
#=GF DR   INTERPRO; IPR022758;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   RecQ helicases unwind DNA in an ATP-dependent manner. Sgs1 has a
#=GF CC   HRDC (helicase and RNaseD C-terminal) domain which modulates the
#=GF CC   helicase function via auxiliary contacts to DNA [1]. 
#=GF SQ   51
#=GS G8BT24_TETPH/1116-1192      AC G8BT24.1
#=GS A0A1E4T0H2_9ASCO/1325-1404  AC A0A1E4T0H2.1
#=GS A0A421JDS2_9ASCO/1083-1142  AC A0A421JDS2.1
#=GS G0VEK8_NAUCC/1173-1252      AC G0VEK8.1
#=GS A0A1A0HF03_9ASCO/955-1033   AC A0A1A0HF03.1
#=GS A0A1S7H8S5_9SACH/1130-1209  AC A0A1S7H8S5.1
#=GS A0A1G4JMP8_9SACH/1219-1299  AC A0A1G4JMP8.1
#=GS G8ZN29_TORDC/1192-1271      AC G8ZN29.1
#=GS A7TK21_VANPO/1114-1193      AC A7TK21.1
#=GS A0A4P6XQQ2_9ASCO/1236-1316  AC A0A4P6XQQ2.1
#=GS A0A376B4S3_9ASCO/1460-1540  AC A0A376B4S3.1
#=GS A0A1E4RFM3_9ASCO/991-1071   AC A0A1E4RFM3.1
#=GS A0A4T0X516_9ASCO/1353-1433  AC A0A4T0X516.1
#=GS G3ALT3_SPAPN/1119-1198      AC G3ALT3.1
#=GS J8Q6B3_SACAR/1284-1363      AC J8Q6B3.1
#=GS K0KTZ4_WICCF/1326-1407      AC K0KTZ4.1
#=GS Q6CR11_KLULA/1207-1288      AC Q6CR11.1
#=GS W1QC66_OGAPD/1093-1172      AC W1QC66.1
#=GS A0A8H7L9T9_9ASCO/1093-1173  AC A0A8H7L9T9.1
#=GS A0A1V2L719_CYBFA/1117-1195  AC A0A1V2L719.1
#=GS A0A512UIT0_9ASCO/1190-1270  AC A0A512UIT0.1
#=GS A0A0H5CCJ9_CYBJN/1191-1271  AC A0A0H5CCJ9.1
#=GS A0A1E4U130_PACTA/1377-1458  AC A0A1E4U130.1
#=GS A0A2H0ZMV9_CANAR/1195-1274  AC A0A2H0ZMV9.1
#=GS A0A1L0BDQ0_9ASCO/1231-1311  AC A0A1L0BDQ0.1
#=GS A0A1S7HJW0_9SACH/1128-1207  AC A0A1S7HJW0.1
#=GS A0A1E3QZC2_9ASCO/619-697    AC A0A1E3QZC2.1
#=GS SGS1_YEAST/1271-1350        AC P35187.1
#=GS A0A448YRK8_BRENA/1034-1113  AC A0A448YRK8.1
#=GS G0WFT3_NAUDC/1268-1347      AC G0WFT3.1
#=GS H2AP53_KAZAF/1145-1224      AC H2AP53.1
#=GS A0A7H9AWR3_ZYGMR/1194-1273  AC A0A7H9AWR3.1
#=GS A0A1G4M9L2_LACFM/1233-1313  AC A0A1G4M9L2.1
#=GS A0A8J5QQL3_9ASCO/1319-1398  AC A0A8J5QQL3.1
#=GS I2GV80_TETBL/1339-1416      AC I2GV80.1
#=GS Q6FLV3_CANGA/1209-1288      AC Q6FLV3.1
#=GS A0A1E4SSL0_9ASCO/1029-1108  AC A0A1E4SSL0.1
#=GS Q755I2_ASHGO/1154-1233      AC Q755I2.2
#=GS G3B3U1_CANTC/906-985        AC G3B3U1.1
#=GS A7TDN2_VANPO/1149-1228      AC A7TDN2.1
#=GS C5E275_LACTC/1239-1319      AC C5E275.1
#=GS C4QZB4_KOMPG/1131-1211      AC C4QZB4.1
#=GS G8JNH4_ERECY/1225-1304      AC G8JNH4.1
#=GS A0A0C7N7N4_9SACH/1240-1320  AC A0A0C7N7N4.1
#=GS I2JSN7_DEKBR/119-199        AC I2JSN7.1
#=GS A0A7D9CWP1_DEKBR/1244-1323  AC A0A7D9CWP1.1
#=GS J7RZZ5_KAZNA/1219-1298      AC J7RZZ5.1
#=GS A0A1X7R0T2_9SACH/1270-1349  AC A0A1X7R0T2.1
#=GS A3LYJ6_PICST/1030-1108      AC A3LYJ6.2
#=GS A0A421JLB9_9ASCO/1021-1100  AC A0A421JLB9.1
#=GS A0A7H9HUE9_9SACH/1186-1265  AC A0A7H9HUE9.1
G8BT24_TETPH/1116-1192                 ............dqpy----LNSAYKKLKEL.SLSLGQHVN.P.P.T.TE.FL.SEDILKKLAKELPKDEPSFKILVNNDPSY..NQ.K..F.K.Y..FKDTIM..VLR-----sn................
A0A1E4T0H2_9ASCO/1325-1404             ...............e--DHIQHCYTALRNH.RNKLNTTLK.F.A.K.AT.TMaSDTTLKAMANKLPTTEQEYGALEDIQANQ..LQ.Y..F.K.R..FEKVLK..VFQSERA-e.................
A0A421JDS2_9ASCO/1083-1142             .......ssirdnlnl---------------.---------.-.-.-.--.TI.SDASLKEMAHMLPTSKKDFVKVGGITKEQ..AQ.D..F.V.H..FKKALA..AIKKEKK-g.................
G0VEK8_NAUCC/1173-1252                 ................ELIDITAAYNKLREV.SLGLGNRMN.P.P.V.MN.FL.SDVALKKLATILPVTPEQFSSIPSIGERQ..RK.K..F.K.Y..FKSTIL..NLRKNRR-n.................
A0A1A0HF03_9ASCO/955-1033              ............kdli-----DKAYFELRNSrTLKVSELGY.A.R.A.EA.FI.GDNLLKEMAIKLPTNARDFARLSNVTKEQ..AD.H..F.K.H..FKQVLT..NLSRER--k.................
A0A1S7H8S5_9SACH/1130-1209             ................ELAELTHAYETLKEL.SLNAGYRMN.P.P.V.AN.FI.PDVALKRLATVLPMTEEEFTNLPDIGEKH..GK.K..F.K.L..FKKSII..ELRKRRN-d.................
A0A1G4JMP8_9SACH/1219-1299             ...............e-QLCITNAYQELKQR.AIELARNQN.Y.P.S.YT.SIiSEQALKRAAFSVPQNENDFVILPNLGDSQ..KR.N..Y.H.H..FKDLFE..ILRLQRD-s.................
G8ZN29_TORDC/1192-1271                 ................ELGELTYAYEKLRET.SLNIGNRMN.P.P.V.AN.FV.SDLVLKKLAKILPVTEEEFNGLLDVTDKN..RN.R..F.K.Y..FKSTIM..ELRKRKI-g.................
A7TK21_VANPO/1114-1193                 ................ELSHITVSYESLRAV.SMSLGNRMN.P.P.I.TN.YL.PDVLIKKIAMALPETEDEFISIVGNFSNH..TR.K..Y.K.Y..FKDTMT..NLRLQRNQ..................
A0A4P6XQQ2_9ASCO/1236-1316             ..............nr--EHIEKAYTELRNFrTLKLQELGY.G.R.A.AA.FI.NDRLMKELAIKLPTNARDFAKLDSVTKEQ..HD.H..F.I.H..FKKILA..TLARDRK-k.................
A0A376B4S3_9ASCO/1460-1540             ...............q-LSNITEAYNKLKEI.AIKKKEFLG.InK.L.HT.FI.TEQALRNAAIHLPTTKQEFGKLEGLGPRQ..EN.R..F.I.H..FKSALI..ELKNTRD-e.................
A0A1E4RFM3_9ASCO/991-1071              ..............nk--QHVEFCYKELNNL.RIQKSFELG.Y.G.QsNN.FI.NEPTLKDMSIKLPTNKKDFIKLKNLNKDQ..QE.Y..F.M.H..FKKLLM..QLSRERKK..................
A0A4T0X516_9ASCO/1353-1433             ..............kr--MHLDQCYGRLRER.RKQLATLKN.F.T.K.ET.TLaSDTMLKDMALTLPINAVTYEKLEDFKTSQ..GA.Y..F.C.M..FKSTIE..ELRKERI-v.................
G3ALT3_SPAPN/1119-1198                 ..............dl--PHIEKSFQELSHI.RSNASVQVG.M.R.N.QL.LI.SDNTLKDMSRNLPTNKKDFSKLIGISREQ..TE.Y..F.H.Y..FKKDLA..RLARERK-k.................
J8Q6B3_SACAR/1284-1363                 ................ELNNLRMTYERLREL.SLNLGNRMV.P.P.V.GN.FM.PDSILKKMATILPTNDSAFSVLGPIEDRY..RR.R..F.K.Y..FKATIT..DLSKKRS-s.................
K0KTZ4_WICCF/1326-1407                 ...............e-KRDYSRAFISLKEA.RDKAMSRLN.V.S.A.ST.SVaSDRLLKTMARKLPQTDFEFKQLEGFENEI..QKgY..F.N.Y..FKQVLQ..NFKNLK--tn................
Q6CR11_KLULA/1207-1288                 ................EQAHITKCFNLLKDI.AINVSSKFN.F.P.N.DT.MLiSDAILWKAANKLPADQASFANLNGSNDPA.lAK.R..F.K.Y..FSATLK..KCKKERHH..................
W1QC66_OGAPD/1093-1172                 ...............a--DHINKSYLKLREH.RSLCSTHLN.H.S.R.DS.TMaSDTTLKDMAMKLPTTKMEYDRLDGMEKNQ..TQ.Y..F.Q.K..FERVLG..ALRQER--da................
A0A8H7L9T9_9ASCO/1093-1173             ..............nr--EHIEKAYTELRNFrTLKLQELGY.G.R.A.AA.FI.NDRLMKELAIKLPTNARDFAKLDSVTKEQ..HD.H..F.I.H..FKKILA..TLARDRK-k.................
A0A1V2L719_CYBFA/1117-1195             ..........ekqqyi------EAHRRLKDR.QNEIMSRLN.F.K.K.SS.SVcSQETLKDMALKLPQTETEYKKLRGVDTKQ..PI.Y..F.K.H..FAPLLQ..QLKKE---f.................
A0A512UIT0_9ASCO/1190-1270             ............nkdv----IEKAYNELRNF.RMLKSQELG.Y.G.R.ANvFI.SDILLKEMAIKLPTNARDFAKLNNVSKEQ..TD.H..F.T.H..FKKVLT..SLSRERKK..................
A0A0H5CCJ9_CYBJN/1191-1271             ..........dktrfv------ECYKQLSDK.SHEIMSRLK.F.K.L.SS.SVcTAVTLRDMASKLPQTESEYLQLAGVTTDD.hKK.M..F.K.Y..FEPLLK..KLKS----ega...............
A0A1E4U130_PACTA/1377-1458             ...........eqekf----INKSYGALNDV.RMRKMSELG.I.T.I.SS.HIaSDAVLRELAILLPTTSKDFKKIPGITGKE..AM.N..F.S.T..FKSTLI..KLRKERE-s.................
A0A2H0ZMV9_CANAR/1195-1274             ...........edaae------HAFQELKKI.RHEKSQELR.F.A.R.PS.YLvEDAALREMAVKLPTNARDFAKLENIKKDQ..AP.Y..F.Q.Y..FKKVLT..TLARERK-k.................
A0A1L0BDQ0_9ASCO/1231-1311             .............neq---AIEHAFSELRNL.RLQKLQELG.Y.G.R.PT.FFiDDNLLKEMAIKLPTNARDYARLENIRKEQ..VS.S..F.Q.Y..FKKTLG..TLSRERK-n.................
A0A1S7HJW0_9SACH/1128-1207             ................ELAELTHAYETLKEL.SLNAGYRLN.P.P.V.AN.FI.PDVALKRLATALPMTEEGFTNLPDIGEKH..GK.K..F.K.L..FKKTII..ELRKRRN-d.................
A0A1E3QZC2_9ASCO/619-697               ............sdtd------QAFHALNAL.CVRKQHDLNyM.S.A.SR.VL.SPVSLRDLAAKLPQTKAAFDKTAGILPEQ..KQ.N..F.K.Y..FKPLLK..TLREARD-k.................
SGS1_YEAST/1271-1350                   ................ELNNLRMTYERLREL.SLNLGNRMV.P.P.V.GN.FM.PDSILKKMAAILPMNDSAFATLGTVEDKY..RR.R..F.K.Y..FKATIA..DLSKKRS-s.................
A0A448YRK8_BRENA/1034-1113             ...............r--RHVNECYMRLRTH.RSRASTRFS.H.S.S.ER.SIaSDTTLKDMALKLPSNTMEYTVLDDLKKSQ..VQ.Y..Y.H.V..FQKLLA..VLRKERE-t.................
G0WFT3_NAUDC/1268-1347                 ................ELSALTSAYVKLREV.SLNLGNRMN.P.P.I.AH.FL.SDTSLKKLATNLPITEGQFVAIPTIGEKQ..RK.K..F.K.Y..FKSTLL..MLRKQRN-i.................
H2AP53_KAZAF/1145-1224                 ................EMRGITFAYNKLKDA.SYNIGNRMS.P.P.M.VN.FF.PDTILKKLATLLPPTEEDFSRLVDIEETY..KN.R..F.K.Y..IKPTIL..EIRRS---mmn...............
A0A7H9AWR3_ZYGMR/1194-1273             ................ELSELAYAYEILRDV.SLNAGTQMN.P.P.A.AN.FL.PDLLLKKVAKNLPVTEAEFAALVGPTDIH..RH.K..F.K.Y..FRSAII..DLKRRRIK..................
A0A1G4M9L2_LACFM/1233-1313             ................EQAEITYSYHKLKDR.ASEIARELK.F.NsF.LT.VI.PDCALRKAAVVLPSSVNEFAALPGLNVNQ..TK.Y..Y.K.Y..FKNIMI..ELNQRRR-n.................
A0A8J5QQL3_9ASCO/1319-1398             ................ELPHIEHCYDELSHI.RMNASTEID.I.P.A.HQ.VV.SDRTLKDMSIKLPTNKKDFAKLLEIKKDQ..LE.Y..F.S.Y..FKKSLT..NLSRERKK..................
I2GV80_TETBL/1339-1416                 ................ELSELAFAYEQLHEI.SLNVGNRLN.P.P.V.SN.FL.PDTIVRKVAKLLPVSEEEFGIIVGGNEHH..KK.N..F.D.I..LRIKLW..NYVK----en................
Q6FLV3_CANGA/1209-1288                 ................EVNDLKSAYDRLRNA.AISWGSRMV.P.A.V.NK.FM.DDNVLRRLAAILPATEEEFIGIVGNNSTD..SK.K..Y.K.Y..FKDIFI..DLRKRRIE..................
A0A1E4SSL0_9ASCO/1029-1108             ..............ns--AHIEYAHSELSKI.RIEVLSETS.T.P.L.QQ.VV.SDTALTDMAIKLPTNKKDFAKLTGITKEQ..LE.S..F.N.Y..FKKTLG..FLARERK-k.................
Q755I2_ASHGO/1154-1233                 ...............t-QRHISASYTKLHNI.VTRKTKDYG.YdS.S.DS.FI.PPDVLKQMALLLPQTQWDFDQMSPNM-QL..GS.K..F.K.Y..FKNALV..RLKRERA-s.................
G3B3U1_CANTC/906-985                   .............nrm---HIDRCFHELNLI.RNQRKIELN.F.Q.N.AN.SIlSDDSLKKLAIMLPTSKQEFKKYVNNNDQL..-N.Y..F.I.Y..FKSKLM..ELSRERK-e.................
A7TDN2_VANPO/1149-1228                 ................EAKELNFAFERIKAA.VVEISNRSN.L.P.L.ST.YM.PVNAIKKIATFLPATEDEFVVLLGDNEQN..RR.K..Y.N.D..LRHVIM..NLRKHKMK..................
C5E275_LACTC/1239-1319                 ................EQLSVTSAYQELKER.AISTARELR.F.NgF.MS.VI.SETALRKAAVVLPSTEQQFRQLPGLTSTQ..AQ.H..Y.H.F..FKDLFV..RLNVLR--ks................
C4QZB4_KOMPG/1131-1211                 ................EEAHVEYCYRELNDI.RSRRLHEIG.WkS.S.AT.LV.SDESLRDMAFKLPQNEQEFQSLAGMNPHQ..LQ.Y..F.K.L..FRTKLK..ALMN----irqa..............
G8JNH4_ERECY/1225-1304                 ..............ve--RHISQSYDKLQAV.AIKKAYDYG.Y.T.TpNS.FM.TPHILRNLSVHLPISQPQFDRLCPATESF..-S.K..F.K.Y..FRNLLL..TLKQERE-n.................
A0A0C7N7N4_9SACH/1240-1320             ................EQLSVTVAYQELRQR.AMQVASKAG.Y.NsF.MG.II.SEQALKKAAVTLPSSLEQFRLLPNLTASQ..QQ.N..Y.T.H..FQELLT..VLRSKRR-s.................
I2JSN7_DEKBR/119-199                   ..............mk--SHVNECYXRLRAQ.RSRASTRFS.H.A.S.ET.SIaSDTTLKDMALKLPSTEMEYTVLDDLKKSQ..MQ.Y..F.S.V..FKRXLG..NLRKERE-k.................
A0A7D9CWP1_DEKBR/1244-1323             ...............k--SHVNECYMRLRAQ.RSRASTRFS.H.A.S.ET.SIaSDTTLKDMALKLPSTEMEYTVLDDLKKSQ..MQ.Y..F.S.V..FKRVLG..NLRKERE-k.................
J7RZZ5_KAZNA/1219-1298                 ...............q-LSDLTDAYNKLKEV.SLSLGHRTN.P.P.T.VN.FL.PDSLLRKIARCLPVTEEEFSSFPELRRQD..HK.K..F.K.Y..IRPTIM..ELRKRRM-a.................
A0A1X7R0T2_9SACH/1270-1349             ................ELSDITFAYNKLREV.SLELANRAN.P.P.I.RN.FL.PDGLLKKLATILPATQEEYVSIPDVQGNL..RN.K..F.R.H..IKPTIM..ELRKRRIQ..................
A3LYJ6_PICST/1030-1108                 ..............ns---NANHAYNELNKI.RIEASSEIG.I.P.L.SQ.FV.SEISLREMSNKLPTNKRDFSKIQGILKEQ..VE.Y..F.T.L..FKKTLG..ILSRERK-k.................
A0A421JLB9_9ASCO/1021-1100             ..............dl--PHIEKSYQDLNHI.RLNTSVQVG.V.R.N.QM.LI.SDNTLKDMSKSLPTNKRDFSRLVDISKEQ..AE.Y..F.H.Y..FKKDLA..RLARERK-k.................
A0A7H9HUE9_9SACH/1186-1265             ................ELSELTFAFQKLKET.SLNIGNRLH.P.P.V.AN.YL.PDLILKKLAKILPVTEEEFAGLLDVGDKH..RH.K..F.K.H..FKNIIM..ELRKRRI-g.................
#=GC seq_cons                          ..................tclspuYpcL+ch.phphupchs.h.s.h.ss.hl.sDssLKchAhpLPsocp-FspLsslscpp..tp.p..F.c.a..FKpsLh..pL++cRp.p.................
//