GenomeNet

Database: Pfam
Entry: PP1_inhibitor
LinkDB: PP1_inhibitor
Original site: PP1_inhibitor 
#=GF ID   PP1_inhibitor
#=GF AC   PF05361.11
#=GF DE   PKC-activated protein phosphatase-1 inhibitor
#=GF AU   Finn RD
#=GF SE   Pfam-B_69711 (release 7.8)
#=GF GA   20.70 20.70;
#=GF TC   20.70 20.80;
#=GF NC   20.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11734001
#=GF RT   Solution NMR structure of the myosin phosphatase inhibitor
#=GF RT   protein CPI-17 shows phosphorylation-induced conformational
#=GF RT   changes responsible for activation. 
#=GF RA   Ohki S, Eto M, Kariya E, Hayano T, Hayashi Y, Yazawa M,
#=GF RA   Brautigan D, Kainosho M; 
#=GF RL   J Mol Biol 2001;314:839-849.
#=GF DR   INTERPRO; IPR008025;
#=GF DR   SCOP; 1k5o; fa;
#=GF CC   Contractility of vascular smooth muscle depends on
#=GF CC   phosphorylation of myosin light chains, and is modulated by
#=GF CC   hormonal control of myosin phosphatase activity. Signaling
#=GF CC   pathways activate kinases such as PKC or Rho-dependent kinases
#=GF CC   that phosphorylate the myosin phosphatase inhibitor protein
#=GF CC   called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its
#=GF CC   inhibitory potency 1000-fold, creating a molecular switch for
#=GF CC   regulating contraction [1].
#=GF SQ   368
#=GS H0VQA4_CAVPO/25-146       AC H0VQA4.1
#=GS G3UIU2_LOXAF/1-119        AC G3UIU2.1
#=GS A0A0V1P324_9BILA/2-109    AC A0A0V1P324.1
#=GS A0A183P618_9TREM/5-116    AC A0A183P618.1
#=GS B5MC51_HUMAN/519-629      AC B5MC51.1
#=GS G3PAR8_GASAC/38-143       AC G3PAR8.1
#=GS W5KGT9_ASTMX/12-150       AC W5KGT9.1
#=GS A0A093F3P3_GAVST/1-65     AC A0A093F3P3.1
#=GS W5NH63_LEPOC/30-141       AC W5NH63.1
#=GS M3ZWL2_XIPMA/6-125        AC M3ZWL2.1
#=GS G3HJA1_CRIGR/172-243      AC G3HJA1.1
#=GS A0A0N1PG86_PAPMA/142-202  AC A0A0N1PG86.1
#=GS M3Z2C2_MUSPF/1-113        AC M3Z2C2.1
#=GS F7H6G2_CALJA/37-164       AC F7H6G2.1
#=GS F6T2P4_MACMU/93-156       AC F6T2P4.1
#=GS I3IVJ1_ORENI/32-141       AC I3IVJ1.1
#=GS W5QGE0_SHEEP/32-151       AC W5QGE0.1
#=GS H9GBT4_ANOCA/1-64         AC H9GBT4.1
#=GS F6Q451_CALJA/39-147       AC F6Q451.1
#=GS J9APU5_WUCBA/1-60         AC J9APU5.1
#=GS G3TNN7_LOXAF/23-145       AC G3TNN7.1
#=GS G3Q899_GASAC/21-139       AC G3Q899.1
#=GS A0A0D9R3U4_CHLSB/60-178   AC A0A0D9R3U4.1
#=GS B0WBN1_CULQU/4-123        AC B0WBN1.1
#=GS A0A087YJF2_POEFO/1-142    AC A0A087YJF2.1
#=GS H3BAE8_LATCH/1-141        AC H3BAE8.1
#=GS A0A016UXK2_9BILA/1-87     AC A0A016UXK2.1
#=GS G3VPI7_SARHA/1-62         AC G3VPI7.1
#=GS G1SP96_RABIT/24-145       AC G1SP96.1
#=GS A0A068XKP5_HYMMI/3-101    AC A0A068XKP5.1
#=GS K7FY66_PELSI/28-146       AC K7FY66.1
#=GS A0A088ASZ5_APIME/4-126    AC A0A088ASZ5.1
#=GS A0A0V0S130_9BILA/3-111    AC A0A0V0S130.1
#=GS R4G9M6_ANOCA/1-142        AC R4G9M6.1
#=GS G8F528_MACFA/93-156       AC G8F528.1
#=GS W5NM54_LEPOC/6-66         AC W5NM54.1
#=GS U3JUF6_FICAL/5-129        AC U3JUF6.1
#=GS G1NJ36_MELGA/1-64         AC G1NJ36.2
#=GS F7GNA1_MACMU/1-45         AC F7GNA1.1
#=GS A0A091CQK5_FUKDA/105-174  AC A0A091CQK5.1
#=GS A0A087Y0W1_POEFO/30-142   AC A0A087Y0W1.1
#=GS PP14D_RAT/21-143          AC Q8K3F4.1
#=GS F6T9E6_CALJA/1-136        AC F6T9E6.1
#=GS F6YMT9_HORSE/1-90         AC F6YMT9.1
#=GS PP14B_HUMAN/39-147        AC Q96C90.3
#=GS A0A085NUE4_9BILA/4-93     AC A0A085NUE4.1
#=GS W5KIW0_ASTMX/1-129        AC W5KIW0.1
#=GS PP14A_MOUSE/1-136         AC Q91VC7.1
#=GS F7ISZ2_CALJA/24-145       AC F7ISZ2.1
#=GS G1RZH1_NOMLE/37-165       AC G1RZH1.1
#=GS H2LLB2_ORYLA/10-128       AC H2LLB2.1
#=GS G3TMV5_LOXAF/40-147       AC G3TMV5.1
#=GS U3J9G3_ANAPL/6-136        AC U3J9G3.1
#=GS H3D9R5_TETNG/2-136        AC H3D9R5.1
#=GS A0A091LEI3_9GRUI/1-63     AC A0A091LEI3.1
#=GS G3RNV8_GORGO/24-145       AC G3RNV8.1
#=GS G7PXF8_MACFA/1-97         AC G7PXF8.1
#=GS A0A016UZ39_9BILA/1-96     AC A0A016UZ39.1
#=GS A0A183JFE9_9TREM/5-120    AC A0A183JFE9.1
#=GS Q9VKQ5_DROME/4-124        AC Q9VKQ5.1
#=GS PP14B_MOUSE/39-147        AC Q62084.2
#=GS H3B0M7_LATCH/6-127        AC H3B0M7.1
#=GS I3K793_ORENI/17-136       AC I3K793.1
#=GS G1MIW0_AILME/1-108        AC G1MIW0.1
#=GS A0A0P7UXG6_9TELE/9-95     AC A0A0P7UXG6.1
#=GS PP14A_HUMAN/1-139         AC Q96A00.1
#=GS A0A140LI58_MOUSE/1-109    AC A0A140LI58.1
#=GS PP14D_HUMAN/24-145        AC Q9NXH3.1
#=GS G3Q9T0_GASAC/2-137        AC G3Q9T0.1
#=GS F7CUW3_XENTR/6-127        AC F7CUW3.1
#=GS A0A0N5DCW8_TRIMR/4-109    AC A0A0N5DCW8.1
#=GS W5JBN9_ANODA/5-123        AC W5JBN9.1
#=GS I3MYR4_ICTTR/36-142       AC I3MYR4.1
#=GS W5P696_SHEEP/1-119        AC W5P696.1
#=GS I3LZL5_ICTTR/1-107        AC I3LZL5.1
#=GS G1TVU9_RABIT/1-105        AC G1TVU9.1
#=GS Q14BX6_MOUSE/38-153       AC Q14BX6.1
#=GS F6TJM9_CALJA/67-110       AC F6TJM9.1
#=GS G1P2P3_MYOLU/23-145       AC G1P2P3.1
#=GS M7AMN9_CHEMY/61-146       AC M7AMN9.1
#=GS F5GXC4_HUMAN/1-45         AC F5GXC4.1
#=GS A0A132A5U3_SARSC/2-88     AC A0A132A5U3.1
#=GS A0A0P7UKZ5_9TELE/23-130   AC A0A0P7UKZ5.1
#=GS F6XG02_MACMU/1-22         AC F6XG02.1
#=GS L5LDG6_MYODS/29-97        AC L5LDG6.1
#=GS F6SZL7_MONDO/28-148       AC F6SZL7.1
#=GS A0A0N4TYJ3_BRUPA/1-89     AC A0A0N4TYJ3.1
#=GS S7N667_MYOBR/1-133        AC S7N667.1
#=GS A0A0V1MEJ6_9BILA/3-132    AC A0A0V1MEJ6.1
#=GS F1NQV6_CHICK/73-207       AC F1NQV6.2
#=GS Q29KQ3_DROPS/2-123        AC Q29KQ3.1
#=GS F6TA78_CALJA/1-128        AC F6TA78.1
#=GS Q7YX00_CAEEL/5-112        AC Q7YX00.1
#=GS A0A016UWD5_9BILA/1-71     AC A0A016UWD5.1
#=GS H2R706_PANTR/579-684      AC H2R706.1
#=GS F6ZGW6_HORSE/1-81         AC F6ZGW6.1
#=GS A0A091RTY3_NESNO/1-63     AC A0A091RTY3.1
#=GS W5NPN6_SHEEP/13-107       AC W5NPN6.1
#=GS H9G7F4_ANOCA/19-148       AC H9G7F4.2
#=GS K7EJB8_HUMAN/1-116        AC K7EJB8.1
#=GS H2MPY2_ORYLA/26-136       AC H2MPY2.1
#=GS E9PAT1_HUMAN/24-89        AC E9PAT1.1
#=GS M3YG61_MUSPF/33-109       AC M3YG61.1
#=GS F1PCV4_CANLF/39-147       AC F1PCV4.2
#=GS A0A0J9YA29_BRUMA/1-89     AC A0A0J9YA29.1
#=GS U3KCG3_FICAL/2-70         AC U3KCG3.1
#=GS A0A096N5A3_PAPAN/31-136   AC A0A096N5A3.1
#=GS F6TJM9_CALJA/1-69         AC F6TJM9.1
#=GS I3MQH8_ICTTR/18-140       AC I3MQH8.1
#=GS F7BC28_XENTR/28-153       AC F7BC28.1
#=GS I3KKU4_ORENI/1-108        AC I3KKU4.1
#=GS A0A0B4J2A3_HUMAN/1-71     AC A0A0B4J2A3.1
#=GS B4Q9T3_DROSI/4-124        AC B4Q9T3.1
#=GS Q0P4A9_DANRE/1-129        AC Q0P4A9.1
#=GS F6Y6N5_ORNAN/1-89         AC F6Y6N5.1
#=GS H2UV74_TAKRU/39-146       AC H2UV74.1
#=GS A0A139WCI8_TRICA/19-120   AC A0A139WCI8.1
#=GS T1H7V0_RHOPR/1-55         AC T1H7V0.1
#=GS A0A091ICJ7_CALAN/1-65     AC A0A091ICJ7.1
#=GS A0A151PE73_ALLMI/1-68     AC A0A151PE73.1
#=GS A0A091GWJ5_BUCRH/1-63     AC A0A091GWJ5.1
#=GS A0A0R3PES6_ANGCS/10-118   AC A0A0R3PES6.1
#=GS A0A158Q2H3_DRAME/23-95    AC A0A158Q2H3.1
#=GS PP14B_RAT/39-147          AC Q8K3F3.1
#=GS S9X907_CAMFR/2-113        AC S9X907.1
#=GS F7DZ04_CALJA/37-165       AC F7DZ04.1
#=GS G1Q788_MYOLU/1-131        AC G1Q788.1
#=GS A0A091DRN7_FUKDA/23-146   AC A0A091DRN7.1
#=GS A0A096NTI9_PAPAN/24-145   AC A0A096NTI9.1
#=GS B4JE51_DROGR/45-167       AC B4JE51.1
#=GS G1MI51_AILME/40-148       AC G1MI51.1
#=GS A0A093C5T6_9AVES/1-83     AC A0A093C5T6.1
#=GS A0A091V6I6_PHORB/1-63     AC A0A091V6I6.1
#=GS W7UAB5_9STRA/34-161       AC W7UAB5.1
#=GS G4V8M7_SCHMA/8-125        AC G4V8M7.1
#=GS A0A0D9RPN8_CHLSB/37-165   AC A0A0D9RPN8.1
#=GS G3Q897_GASAC/11-128       AC G3Q897.1
#=GS M4ATZ5_XIPMA/1-141        AC M4ATZ5.1
#=GS A0A0D8XE03_DICVI/1-99     AC A0A0D8XE03.1
#=GS B4GSZ8_DROPE/2-123        AC B4GSZ8.1
#=GS F7DGQ5_HORSE/23-145       AC F7DGQ5.1
#=GS H2L400_ORYLA/1-139        AC H2L400.1
#=GS A0A096MQE4_PAPAN/39-155   AC A0A096MQE4.1
#=GS W5P5T6_SHEEP/41-147       AC W5P5T6.1
#=GS M7AMN9_CHEMY/4-65         AC M7AMN9.1
#=GS G3WTH4_SARHA/28-148       AC G3WTH4.1
#=GS H2WGE8_CAEJA/5-112        AC H2WGE8.1
#=GS A0A0F8D1C2_LARCR/32-142   AC A0A0F8D1C2.1
#=GS B4HWV3_DROSE/4-124        AC B4HWV3.1
#=GS A0A0G2KI20_DANRE/6-62     AC A0A0G2KI20.1
#=GS J9P3B5_CANLF/1-68         AC J9P3B5.1
#=GS M4A4Y5_XIPMA/40-149       AC M4A4Y5.1
#=GS A0A0V1KT05_9BILA/3-111    AC A0A0V1KT05.1
#=GS Q4KMJ9_DANRE/21-134       AC Q4KMJ9.1
#=GS E9FR70_DAPPU/11-139       AC E9FR70.1
#=GS A0A0Q3PGD4_AMAAE/120-167  AC A0A0Q3PGD4.1
#=GS H2SY42_TAKRU/1-143        AC H2SY42.1
#=GS G3ICK0_CRIGR/18-89        AC G3ICK0.1
#=GS A0A0N4YTH9_NIPBR/3-100    AC A0A0N4YTH9.1
#=GS Q66KC0_XENTR/1-138        AC Q66KC0.1
#=GS A0A091W433_OPIHO/1-83     AC A0A091W433.1
#=GS G1S4X8_NOMLE/1-139        AC G1S4X8.1
#=GS A0A091GKF8_9AVES/1-63     AC A0A091GKF8.1
#=GS A0A151MV29_ALLMI/2-124    AC A0A151MV29.1
#=GS B3MJV5_DROAN/4-124        AC B3MJV5.1
#=GS A0A087VYY7_ECHMU/2-91     AC A0A087VYY7.1
#=GS G3SB74_GORGO/3-116        AC G3SB74.1
#=GS A0A0Q3PGD4_AMAAE/39-102   AC A0A0Q3PGD4.1
#=GS G1QC33_MYOLU/48-171       AC G1QC33.1
#=GS E2RES0_CANLF/31-150       AC E2RES0.2
#=GS A0A0C2G8V1_9BILA/1-121    AC A0A0C2G8V1.1
#=GS G1NF46_MELGA/27-159       AC G1NF46.1
#=GS T1J181_STRMM/18-142       AC T1J181.1
#=GS Q641W6_RAT/31-147         AC Q641W6.1
#=GS A0A0R3S1L8_9BILA/1-89     AC A0A0R3S1L8.1
#=GS W5KP38_ASTMX/13-156       AC W5KP38.1
#=GS F6Q2M3_HORSE/2-112        AC F6Q2M3.1
#=GS I1FA42_AMPQE/1-118        AC I1FA42.1
#=GS H2PKM0_PONAB/19-90        AC H2PKM0.1
#=GS A0A016UX18_9BILA/1-62     AC A0A016UX18.1
#=GS B4KKN4_DROMO/4-124        AC B4KKN4.1
#=GS A5PK48_BOVIN/23-144       AC A5PK48.1
#=GS T1L0E3_TETUR/2-81         AC T1L0E3.2
#=GS H2L405_ORYLA/1-137        AC H2L405.1
#=GS A0A0N8JZ22_9TELE/1-140    AC A0A0N8JZ22.1
#=GS F1S7V6_PIG/37-165         AC F1S7V6.1
#=GS H2U8C0_TAKRU/4-126        AC H2U8C0.1
#=GS A0A0A0A3K4_CHAVO/1-63     AC A0A0A0A3K4.1
#=GS H0UZP4_CAVPO/1-85         AC H0UZP4.1
#=GS A0A093D2C9_TAUER/1-94     AC A0A093D2C9.1
#=GS A0A0N0U564_9HYME/4-126    AC A0A0N0U564.1
#=GS H0X246_OTOGA/1-136        AC H0X246.1
#=GS E1B7I6_BOVIN/26-142       AC E1B7I6.2
#=GS A0A099ZB81_TINGU/1-95     AC A0A099ZB81.1
#=GS A0A087UWI9_9ARAC/20-140   AC A0A087UWI9.1
#=GS G5BM01_HETGA/23-91        AC G5BM01.1
#=GS A0A091SDS1_9GRUI/1-63     AC A0A091SDS1.1
#=GS A0A0N5AA94_9BILA/1-85     AC A0A0N5AA94.1
#=GS Q7ZZ37_DANRE/4-128        AC Q7ZZ37.1
#=GS A0A0V0ZL61_9BILA/3-111    AC A0A0V0ZL61.1
#=GS A0A0N4YGL5_NIPBR/2-113    AC A0A0N4YGL5.1
#=GS G3QT63_GORGO/24-89        AC G3QT63.1
#=GS C5EPD7_9FIRM/3-55         AC C5EPD7.1
#=GS A0A075AJI3_9TREM/3-119    AC A0A075AJI3.1
#=GS A0A0D9QVT4_CHLSB/1-139    AC A0A0D9QVT4.1
#=GS E1C0X7_CHICK/29-148       AC E1C0X7.2
#=GS A0A0N5DB13_THECL/1-86     AC A0A0N5DB13.1
#=GS H2R1S8_PANTR/37-165       AC H2R1S8.1
#=GS Q0VCI8_BOVIN/41-168       AC Q0VCI8.1
#=GS L9JC38_TUPCH/17-148       AC L9JC38.1
#=GS A0A151MUY0_ALLMI/2-126    AC A0A151MUY0.1
#=GS A0A154NXR0_9HYME/4-126    AC A0A154NXR0.1
#=GS G3UM52_LOXAF/1-130        AC G3UM52.1
#=GS H3DFW4_TETNG/34-143       AC H3DFW4.1
#=GS W6V135_ECHGR/3-102        AC W6V135.1
#=GS G6D1C0_DANPL/133-190      AC G6D1C0.1
#=GS H0VVT5_CAVPO/1-64         AC H0VVT5.1
#=GS L9JP28_TUPCH/1-78         AC L9JP28.1
#=GS G3X024_SARHA/46-173       AC G3X024.1
#=GS H3D652_TETNG/22-141       AC H3D652.1
#=GS M7BJZ3_CHEMY/1-103        AC M7BJZ3.1
#=GS H2NMV7_PONAB/24-145       AC H2NMV7.1
#=GS A0A091FQQ2_CORBR/1-63     AC A0A091FQQ2.1
#=GS A0A0N4VBG5_ENTVE/1-38     AC A0A0N4VBG5.1
#=GS L5KNJ1_PTEAL/1-134        AC L5KNJ1.1
#=GS B7PSA9_IXOSC/1-55         AC B7PSA9.1
#=GS A0A0R3X019_HYDTA/2-89     AC A0A0R3X019.1
#=GS E2RC84_CANLF/37-140       AC E2RC84.1
#=GS A0A0K0JEL3_BRUMA/1-113    AC A0A0K0JEL3.1
#=GS A0A0V0VJM1_9BILA/3-111    AC A0A0V0VJM1.1
#=GS I3K2I7_ORENI/3-122        AC I3K2I7.1
#=GS A0A091TDG8_PHALP/1-63     AC A0A091TDG8.1
#=GS G3N903_GASAC/1-138        AC G3N903.1
#=GS A0A0F8AEN0_LARCR/2-108    AC A0A0F8AEN0.1
#=GS A0A087XLT4_POEFO/21-140   AC A0A087XLT4.2
#=GS B4MU57_DROWI/4-124        AC B4MU57.1
#=GS T0MDQ8_CAMFR/48-143       AC T0MDQ8.1
#=GS K7EMN0_HUMAN/1-95         AC K7EMN0.1
#=GS PP14D_MOUSE/22-143        AC Q7TT52.2
#=GS G3TFA0_LOXAF/37-166       AC G3TFA0.1
#=GS D2GW97_AILME/23-145       AC D2GW97.1
#=GS W5NY86_SHEEP/1-64         AC W5NY86.1
#=GS PP14C_MOUSE/36-164        AC Q8R4S0.1
#=GS A0A0P7TYQ3_9TELE/2-104    AC A0A0P7TYQ3.1
#=GS F6RDK6_MACMU/39-108       AC F6RDK6.1
#=GS M4A2I6_XIPMA/10-128       AC M4A2I6.1
#=GS G5AMC3_HETGA/15-94        AC G5AMC3.1
#=GS W5LF96_ASTMX/8-127        AC W5LF96.1
#=GS A0A091JQC0_9AVES/1-63     AC A0A091JQC0.1
#=GS G3RYU7_GORGO/44-149       AC G3RYU7.1
#=GS A8Y4I0_CAEBR/5-112        AC A8Y4I0.1
#=GS A0A183E909_9BILA/2-62     AC A0A183E909.1
#=GS M3YP53_MUSPF/37-145       AC M3YP53.1
#=GS S9WX33_CAMFR/6-67         AC S9WX33.1
#=GS G1QYA5_NOMLE/39-147       AC G1QYA5.1
#=GS F6Y7A1_CANLF/52-174       AC F6Y7A1.1
#=GS M7CFF9_CHEMY/3-104        AC M7CFF9.1
#=GS H2RF42_PANTR/39-147       AC H2RF42.1
#=GS C3Y0Q5_BRAFL/4-62         AC C3Y0Q5.1
#=GS G3R934_GORGO/41-87        AC G3R934.1
#=GS G3QTH2_GORGO/1-139        AC G3QTH2.1
#=GS A0A087V9Q6_BALRE/1-63     AC A0A087V9Q6.1
#=GS I3KFM0_ORENI/2-136        AC I3KFM0.1
#=GS G7PAX8_MACFA/1-45         AC G7PAX8.1
#=GS E3MQD0_CAERE/5-112        AC E3MQD0.1
#=GS A0A0N8K315_9TELE/7-80     AC A0A0N8K315.1
#=GS G1PXW0_MYOLU/38-166       AC G1PXW0.1
#=GS D6X289_TRICA/19-143       AC D6X289.2
#=GS A0A162CT65_9CRUS/26-154   AC A0A162CT65.1
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R4G9M6_ANOCA/1-142                   ....................................MAANRVGRRLGRASPARPSa....alSP.E..A.S.RTdrtpspgI..Q..RR...Q..AR...V.TVKYD...RRE...L...QR...RLDTEKWIDGRLEELYQ.....G............Q.....E..E...E.......M.PD.......E.....V..N..I..DALLEMGTDSERA....K....KL.QSIL...E..S....C...H...N.....N...TEE...FIQELLGKLRGLRTEHVLRR------------------tspggrvdv..........................
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A0A0B2V2F8_TOXCA/2-88                ..........................erncvkrefc------------------S.......TT.D..K.L.LQ.......T..A..ER...G..RV...L.TMKYG...KHQ...MmliRK...RMAIENWLDDRLLELYD.....G............A.....V..D...-.......-.-F.......D.....I..D..I..DKVLDLNTATERK....Q....Y-.----...-..-....-...-...-.....-...---...--------------------------------------vlvssf.............................
#=GC SS_cons                         ....................................XXXXXXXXXXXXXXXXXXX.......XX.-..-.S.SSS....SSS..-..S-...S..SS...S.SSSS-...SSS...S...CH...HHHHHHHHHHHHHHCSS.....S............S.....S..T...T.......S.-S.......S.....S..H..H..HHHHCTSSTTHHH....H....HH.HHHH...T..T....C...S...S.....T...THH...HHHHHHHHCTTT--XXXXXX------------------XXXXXX.............................
#=GC seq_cons                        .................................t.....................................................++...p..u+...l.TlKYs...R+p...L...p+...RLslEpWI.tpLpcLYp.....s............p.....-..c...p.......h.st.......E.....I..D..l..D-LL-hso--pRt....t....+l.pthL......s....C.......p.....s...s-t...Flp-LLs+l+th.h...........................................................
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