#=GF ID Peptidase_C26
#=GF AC PF07722.8
#=GF DE Peptidase C26
#=GF AU Studholme DJ
#=GF SE MEROPS
#=GF GA 20.50 20.50;
#=GF TC 20.50 20.50;
#=GF NC 20.40 20.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 11953431
#=GF RT Three-dimensional structure of human gamma -glutamyl hydrolase.
#=GF RT A class I glatamine amidotransferase adapted for a complex
#=GF RT substate.
#=GF RA Li H, Ryan TJ, Chave KJ, Van Roey P;
#=GF RL J Biol Chem 2002;277:24522-24529.
#=GF DR INTERPRO; IPR011697;
#=GF DR MEROPS; C26;
#=GF CC These peptidases have gamma-glutamyl hydrolase activity; that is
#=GF CC they catalyse the cleavage of the gamma-glutamyl bond in
#=GF CC poly-gamma-glutamyl substrates. They are structurally related to
#=GF CC Pfam:PF00117, but contain extensions in four loops and at the C
#=GF CC terminus [1].
#=GF SQ 3232
#=GS F4DTT1_PSEMN/13-231 AC F4DTT1.1
#=GS A6CYI1_9VIBR/1-201 AC A6CYI1.1
#=GS B2E8M8_BIFAN/1-188 AC B2E8M8.1
#=GS B8KJU0_9GAMM/11-167 AC B8KJU0.1
#=GS Q7MQM5_WOLSU/38-181 AC Q7MQM5.1
#=GS A5MQI1_STRPN/4-209 AC A5MQI1.1
#=GS F5U4Q0_STREQ/4-211 AC F5U4Q0.1
#=GS G7IC70_MEDTR/14-255 AC G7IC70.1
#=GS G5FKF4_9CLOT/3-226 AC G5FKF4.1
#=GS E9FJW4_9STRE/4-209 AC E9FJW4.1
#=GS H5PIP5_ECOLX/4-220 AC H5PIP5.1
#=GS F7SKU3_9GAMM/4-199 AC F7SKU3.1
#=GS C7BN50_PHOAA/70-160 AC C7BN50.1
#=GS D1YK29_9LACO/3-218 AC D1YK29.1
#=GS H0QR00_ARTGO/107-308 AC H0QR00.1
#=GS G9WNH7_9FIRM/4-220 AC G9WNH7.1
#=GS H0BDW6_9ACTO/4-211 AC H0BDW6.1
#=GS G5SY60_ECOLX/8-224 AC G5SY60.1
#=GS E8S9S7_MICSL/3-211 AC E8S9S7.1
#=GS G6L4C3_STRPN/4-209 AC G6L4C3.1
#=GS F3XM80_STRPN/4-209 AC F3XM80.1
#=GS Q3DRW6_STRAG/5-210 AC Q3DRW6.1
#=GS H5FVK3_ECOLX/4-220 AC H5FVK3.1
#=GS A6GSC6_9BURK/13-175 AC A6GSC6.1
#=GS A2W8X8_9BURK/17-236 AC A2W8X8.1
#=GS G6K0T1_STRPN/4-209 AC G6K0T1.1
#=GS F4QE72_DICFS/40-254 AC F4QE72.1
#=GS E2K4E7_ECO57/4-220 AC E2K4E7.1
#=GS Q8FV66_BRUSU/11-229 AC Q8FV66.1
#=GS H7KW39_STRPN/4-209 AC H7KW39.1
#=GS G5VMU4_ECOLX/8-224 AC G5VMU4.1
#=GS H0QK47_ARTGO/1-150 AC H0QK47.1
#=GS G5K983_9STRE/4-191 AC G5K983.1
#=GS C9A0P8_ENTGA/5-219 AC C9A0P8.1
#=GS E4N302_KITSK/1-212 AC E4N302.1
#=GS E6SI86_THEM7/108-304 AC E6SI86.1
#=GS A7T4Z6_NEMVE/70-251 AC A7T4Z6.1
#=GS C2EU57_9LACO/3-217 AC C2EU57.1
#=GS H0TL73_9BRAD/4-229 AC H0TL73.1
#=GS G9RD99_9ENTR/8-224 AC G9RD99.1
#=GS H7QVR3_CAMCO/3-127 AC H7QVR3.1
#=GS B4LHY6_DROVI/33-268 AC B4LHY6.1
#=GS E1D986_VIBPA/7-226 AC E1D986.1
#=GS F5QXF8_SHIFL/8-224 AC F5QXF8.1
#=GS E9WS65_ECOLX/4-220 AC E9WS65.1
#=GS F5VU45_STROR/4-88 AC F5VU45.1
#=GS H7TVR2_CAMCO/37-127 AC H7TVR2.1
#=GS G2N357_MYCTU/66-279 AC G2N357.1
#=GS C5Z191_SORBI/56-271 AC C5Z191.1
#=GS I0W3L9_9STRE/4-209 AC I0W3L9.1
#=GS Q48TN0_STRPM/4-211 AC Q48TN0.1
#=GS F3KW63_9BURK/1-222 AC F3KW63.1
#=GS H8KI70_RICR3/5-222 AC H8KI70.1
#=GS E2Y296_ENTFL/4-220 AC E2Y296.1
#=GS H8HTM8_MYCTU/66-279 AC H8HTM8.1
#=GS G6YZE4_9ALTE/49-210 AC G6YZE4.1
#=GS Q2S3X7_SALRD/3-206 AC Q2S3X7.1
#=GS E7PNY0_PSESG/5-221 AC E7PNY0.1
#=GS E8K033_9STRE/4-209 AC E8K033.1
#=GS B3EBR0_GEOLS/4-191 AC B3EBR0.1
#=GS B8ZPD0_STRPJ/4-209 AC B8ZPD0.1
#=GS A4TCD5_MYCGI/7-227 AC A4TCD5.1
#=GS D4LDR0_RUMC1/4-212 AC D4LDR0.1
#=GS Q3JQI0_BURP1/97-315 AC Q3JQI0.1
#=GS H5D1R8_ECOLX/4-220 AC H5D1R8.1
#=GS D2W1H4_NAEGR/143-320 AC D2W1H4.1
#=GS A8AUM8_STRGC/4-209 AC A8AUM8.1
#=GS E1LG85_STRMT/4-209 AC E1LG85.1
#=GS G6PHM3_STRPN/4-209 AC G6PHM3.1
#=GS D8P9X3_9BACT/3-221 AC D8P9X3.1
#=GS E2ZA49_9FIRM/4-219 AC E2ZA49.1
#=GS I0HGQ8_ACTMI/3-211 AC I0HGQ8.1
#=GS B9YC76_9FIRM/4-217 AC B9YC76.1
#=GS C4I8E7_BURPE/5-224 AC C4I8E7.1
#=GS D8IAM6_BRAP9/3-214 AC D8IAM6.1
#=GS G6GDY5_9FIRM/5-213 AC G6GDY5.1
#=GS G6LMK5_STRPN/4-209 AC G6LMK5.1
#=GS I0QBH2_STROR/4-209 AC I0QBH2.1
#=GS B1MVP3_LEUCK/3-217 AC B1MVP3.1
#=GS H7U586_CAMCO/3-127 AC H7U586.1
#=GS C7WN67_ENTFL/4-220 AC C7WN67.1
#=GS C2MX07_BACCE/3-225 AC C2MX07.1
#=GS C9XVT8_CROTZ/27-244 AC C9XVT8.1
#=GS E1IEA7_9CHLR/2-209 AC E1IEA7.1
#=GS A9WE51_CHLAA/7-223 AC A9WE51.1
#=GS G6SWX2_STRPN/4-209 AC G6SWX2.1
#=GS F6XZT6_CALJA/1-173 AC F6XZT6.1
#=GS H1QFD9_9ACTO/1-95 AC H1QFD9.1
#=GS D3TMZ6_GLOMM/8-236 AC D3TMZ6.1
#=GS E8W709_STRFA/4-213 AC E8W709.1
#=GS Q08SF1_STIAD/6-221 AC Q08SF1.1
#=GS Q67LY5_SYMTH/19-234 AC Q67LY5.1
#=GS H0HN72_9RHIZ/4-223 AC H0HN72.1
#=GS A7B4A7_RUMGN/8-216 AC A7B4A7.1
#=GS H4WQC9_ECOLX/4-220 AC H4WQC9.1
#=GS H8NK23_RICTP/5-259 AC H8NK23.1
#=GS F5QJB6_SHIFL/1-151 AC F5QJB6.1
#=GS G2IX12_PSEUL/4-220 AC G2IX12.1
#=GS I0BR26_9BACL/4-215 AC I0BR26.1
#=GS B1FN20_9BURK/5-224 AC B1FN20.1
#=GS C4ARL0_BURML/192-416 AC C4ARL0.1
#=GS G9PT59_9BACT/19-228 AC G9PT59.1
#=GS C2K0Z6_LACRH/30-249 AC C2K0Z6.1
#=GS F3WWD9_9SPHN/7-222 AC F3WWD9.1
#=GS B2GJU3_KOCRD/10-219 AC B2GJU3.1
#=GS G0HMV7_THES4/3-222 AC G0HMV7.1
#=GS F1VYB9_9BURK/74-298 AC F1VYB9.1
#=GS E0NTU1_9BACT/24-228 AC E0NTU1.1
#=GS C2GTB9_BIFLN/1-126 AC C2GTB9.1
#=GS D5RAY7_FUSNC/4-224 AC D5RAY7.1
#=GS D7MX13_ARALL/1-133 AC D7MX13.1
#=GS D4CXY7_9FUSO/4-224 AC D4CXY7.1
#=GS H4VF28_ECOLX/4-220 AC H4VF28.1
#=GS C7W3L3_ENTFL/4-220 AC C7W3L3.1
#=GS E7P794_PSESG/77-216 AC E7P794.1
#=GS D2U9A7_XANAP/11-245 AC D2U9A7.1
#=GS F0R041_BACSH/27-235 AC F0R041.1
#=GS D8GTQ7_CLOLD/3-218 AC D8GTQ7.1
#=GS H1D7Y5_9FUSO/4-218 AC H1D7Y5.1
#=GS H8NTP1_RAHAQ/18-235 AC H8NTP1.1
#=GS E3F4D6_KETVY/8-227 AC E3F4D6.1
#=GS F2JHD2_CELLD/3-214 AC F2JHD2.1
#=GS I0QAB0_STROR/4-209 AC I0QAB0.1
#=GS B0SW28_CAUSK/3-221 AC B0SW28.1
#=GS E8KLS4_STRSA/4-209 AC E8KLS4.1
#=GS D5THD0_BIFAV/1-188 AC D5THD0.1
#=GS E9HXS3_DAPPU/32-247 AC E9HXS3.1
#=GS D5TAN4_LEGP2/22-149 AC D5TAN4.1
#=GS G6QBF1_STRPN/4-209 AC G6QBF1.1
#=GS I0I5D7_9CHLR/19-238 AC I0I5D7.1
#=GS Q0HG26_SHESM/6-224 AC Q0HG26.1
#=GS G7CVR0_AERSA/1-213 AC G7CVR0.1
#=GS B5ZNR3_RHILW/23-218 AC B5ZNR3.1
#=GS C6V474_NEORI/91-274 AC C6V474.1
#=GS A0DGF9_PARTE/30-245 AC A0DGF9.1
#=GS D0BTT2_9FUSO/4-218 AC D0BTT2.1
#=GS A9P280_PICSI/24-264 AC A9P280.1
#=GS C6SQL5_STRMN/4-211 AC C6SQL5.1
#=GS C0R0F0_BRAHW/2-214 AC C0R0F0.1
#=GS G6J6Q7_STRPN/4-209 AC G6J6Q7.1
#=GS B2Z9Y3_SOLLC/45-261 AC B2Z9Y3.1
#=GS G8T3W2_BRUAO/11-229 AC G8T3W2.1
#=GS D1FBC2_9RHIZ/11-229 AC D1FBC2.1
#=GS H2JLS9_STRHJ/5-212 AC H2JLS9.1
#=GS G1Y910_ECOLX/4-220 AC G1Y910.1
#=GS A2SEW3_METPP/7-235 AC A2SEW3.1
#=GS B9XIA5_9BACT/5-79 AC B9XIA5.1
#=GS H1DL94_9PORP/30-240 AC H1DL94.1
#=GS G2DE32_9GAMM/7-217 AC G2DE32.1
#=GS C4KQS5_BURPE/91-309 AC C4KQS5.1
#=GS G4CFS6_9NEIS/4-222 AC G4CFS6.1
#=GS G8SIF4_ACTS5/3-211 AC G8SIF4.1
#=GS E5BNP9_9FUSO/3-220 AC E5BNP9.2
#=GS E8JDX5_ECO57/4-220 AC E8JDX5.1
#=GS I0VN03_ECOLX/8-224 AC I0VN03.1
#=GS G9WR48_9FIRM/4-220 AC G9WR48.1
#=GS G2IVN6_PSEUL/8-233 AC G2IVN6.1
#=GS E8K8A8_STRPA/9-215 AC E8K8A8.1
#=GS A1K7T7_AZOSB/8-233 AC A1K7T7.1
#=GS F3NLB6_9ACTO/5-214 AC F3NLB6.1
#=GS F8J7R4_HYPSM/5-219 AC F8J7R4.1
#=GS I0YCI2_9BURK/216-440 AC I0YCI2.1
#=GS A4AEZ5_9ACTN/7-223 AC A4AEZ5.1
#=GS B3IEF7_ECOLX/4-220 AC B3IEF7.1
#=GS D5MFJ3_9BACT/3-215 AC D5MFJ3.1
#=GS E6LS64_9FIRM/21-188 AC E6LS64.1
#=GS B0TVD0_SHEHH/7-224 AC B0TVD0.1
#=GS E2YI61_ENTFL/4-220 AC E2YI61.1
#=GS Q1VDT3_VIBAL/7-226 AC Q1VDT3.1
#=GS D3UP93_LISSS/3-218 AC D3UP93.1
#=GS A5MGE5_STRPN/4-209 AC A5MGE5.1
#=GS G9S5J8_9PORP/30-237 AC G9S5J8.1
#=GS E2PLF7_9RHIZ/11-229 AC E2PLF7.1
#=GS A6UY98_PSEA7/5-223 AC A6UY98.1
#=GS E7IMZ8_ECOLX/8-224 AC E7IMZ8.1
#=GS A8EB38_BURPE/5-224 AC A8EB38.1
#=GS B9WSX0_STRSU/4-210 AC B9WSX0.1
#=GS F3EDZ2_PSESL/76-216 AC F3EDZ2.1
#=GS G6M886_STRPN/1-189 AC G6M886.1
#=GS F3UHC7_STRSA/4-210 AC F3UHC7.1
#=GS A1V6P9_BURMS/192-416 AC A1V6P9.1
#=GS E1XY34_LEGPN/64-192 AC E1XY34.1
#=GS H8DQX5_9ENTR/8-224 AC H8DQX5.1
#=GS H8EQW5_CLOTM/6-217 AC H8EQW5.1
#=GS D2ADT7_SHIF2/12-228 AC D2ADT7.1
#=GS F2I4F2_AERUA/5-228 AC F2I4F2.1
#=GS D0LTG0_HALO1/98-235 AC D0LTG0.1
#=GS E1EIS6_VIBPA/7-226 AC E1EIS6.1
#=GS B6UBJ6_MAIZE/56-271 AC B6UBJ6.1
#=GS C9TBH2_9RHIZ/11-229 AC C9TBH2.1
#=GS I0RZY3_MYCXE/1-213 AC I0RZY3.1
#=GS G6FZT6_9CYAN/8-219 AC G6FZT6.1
#=GS D7UNG3_LISMN/3-218 AC D7UNG3.1
#=GS G8PD73_PEDCP/6-223 AC G8PD73.1
#=GS G6VVG9_STRPN/4-209 AC G6VVG9.1
#=GS F0DNV8_9FIRM/3-211 AC F0DNV8.1
#=GS G6ITF2_LACRH/3-223 AC G6ITF2.1
#=GS F9RCN9_9VIBR/7-191 AC F9RCN9.1
#=GS H1E7P6_ECOLX/8-224 AC H1E7P6.1
#=GS F9M9V6_9STRE/4-209 AC F9M9V6.1
#=GS Q03BX9_LACC3/3-224 AC Q03BX9.1
#=GS F7L245_9FUSO/4-224 AC F7L245.1
#=GS D8AY24_ECOLX/8-224 AC D8AY24.1
#=GS D7ZN87_ECOLX/8-224 AC D7ZN87.1
#=GS C9CDI6_ENTFC/3-219 AC C9CDI6.1
#=GS G7S042_STRSU/4-210 AC G7S042.1
#=GS F5NFT4_SHIFL/4-220 AC F5NFT4.1
#=GS D4IW35_BUTFI/1-125 AC D4IW35.1
#=GS G4L2X2_TETHN/4-215 AC G4L2X2.1
#=GS B2DJ98_STRPN/4-209 AC B2DJ98.1
#=GS H7N3P0_STRPN/4-209 AC H7N3P0.1
#=GS H0XE30_OTOGA/34-246 AC H0XE30.1
#=GS G2BNK4_ECOLX/8-224 AC G2BNK4.1
#=GS H5DI72_ECOLX/4-220 AC H5DI72.1
#=GS F6R3K0_ORNAN/1-211 AC F6R3K0.1
#=GS B4PHM7_DROYA/26-244 AC B4PHM7.1
#=GS G6NK71_STRPN/4-209 AC G6NK71.1
#=GS Q63SI3_BURPS/11-229 AC Q63SI3.1
#=GS H0ZLW2_TAEGU/37-249 AC H0ZLW2.1
#=GS H1WMZ8_LEUCI/3-217 AC H1WMZ8.1
#=GS B3NI69_DROER/26-244 AC B3NI69.1
#=GS B9CNM6_9ACTN/24-239 AC B9CNM6.1
#=GS D6LCL1_9FUSO/5-220 AC D6LCL1.1
#=GS C0WAN2_9FIRM/3-226 AC C0WAN2.1
#=GS E7TUG0_ECO57/4-220 AC E7TUG0.1
#=GS F3X9C8_STRPN/4-209 AC F3X9C8.1
#=GS F0FYL5_9BURK/65-289 AC F0FYL5.1
#=GS G0M467_LACPE/4-222 AC G0M467.1
#=GS F3JED5_PSESX/5-221 AC F3JED5.1
#=GS E6FCN6_ENTFL/4-220 AC E6FCN6.1
#=GS B1N1R7_BURPE/5-224 AC B1N1R7.1
#=GS C7Y4U0_9LACO/4-219 AC C7Y4U0.1
#=GS C8T804_KLEPR/8-224 AC C8T804.1
#=GS D6YB93_THEBD/5-211 AC D6YB93.1
#=GS G7SGH0_STRSU/4-208 AC G7SGH0.1
#=GS F3DJE3_9PSED/77-216 AC F3DJE3.1
#=GS F4FX15_LACBN/4-217 AC F4FX15.1
#=GS E8JL84_9ACTO/51-226 AC E8JL84.1
#=GS A8RQ07_9CLOT/4-216 AC A8RQ07.1
#=GS Q3KEE2_PSEPF/5-223 AC Q3KEE2.1
#=GS D7HVY5_PSESS/11-243 AC D7HVY5.1
#=GS G6TA71_STRPN/4-209 AC G6TA71.1
#=GS E1DRD9_VIBPA/7-226 AC E1DRD9.1
#=GS E8XVE5_RAHSY/18-235 AC E8XVE5.1
#=GS F6AFC2_PSEF1/5-221 AC F6AFC2.1
#=GS H2G0M6_OCESG/23-200 AC H2G0M6.1
#=GS G7HDM5_9BURK/5-224 AC G7HDM5.1
#=GS Q1J6P1_STRPF/4-211 AC Q1J6P1.1
#=GS C5WG63_STRDG/4-211 AC C5WG63.1
#=GS D3L5L5_9BACT/3-218 AC D3L5L5.1
#=GS B9PCN2_POPTR/11-237 AC B9PCN2.1
#=GS A7H5D8_CAMJD/16-106 AC A7H5D8.1
#=GS D4CF16_9CLOT/25-239 AC D4CF16.1
#=GS G6S0B6_STRPN/4-209 AC G6S0B6.1
#=GS H2IE20_9VIBR/7-226 AC H2IE20.1
#=GS F0P939_STAPE/3-218 AC F0P939.1
#=GS F2M5J0_LACCC/3-224 AC F2M5J0.1
#=GS E3YR87_9LIST/3-218 AC E3YR87.1
#=GS B2GZA8_BURPE/190-414 AC B2GZA8.1
#=GS C7U9H3_ENTFL/4-220 AC C7U9H3.1
#=GS B2Z9Y5_SOLLC/48-264 AC B2Z9Y5.1
#=GS E9XYG1_ECOLX/4-220 AC E9XYG1.1
#=GS G6PBS6_STRPN/4-209 AC G6PBS6.1
#=GS C8RYZ1_9RHOB/9-228 AC C8RYZ1.1
#=GS E3R6G0_9LACO/4-219 AC E3R6G0.1
#=GS Q8DY50_STRA5/5-210 AC Q8DY50.1
#=GS F0VSQ8_STRG2/4-209 AC F0VSQ8.1
#=GS B7QPM0_9RHOB/34-223 AC B7QPM0.1
#=GS H4RVR5_ECOLX/4-172 AC H4RVR5.1
#=GS H9YJW3_ECOKO/4-220 AC H9YJW3.1
#=GS B3XN77_LACRE/3-217 AC B3XN77.1
#=GS F4ACZ2_LACJH/3-218 AC F4ACZ2.1
#=GS H8IWY4_MYCIA/1-212 AC H8IWY4.1
#=GS B0RRU1_XANCB/5-222 AC B0RRU1.1
#=GS C2KEX8_9LACO/4-219 AC C2KEX8.1
#=GS A3UCY1_9RHOB/23-204 AC A3UCY1.1
#=GS D1NRK3_CLOTM/6-217 AC D1NRK3.1
#=GS F3VSP3_STRPN/4-209 AC F3VSP3.1
#=GS F2DL27_HORVD/85-256 AC F2DL27.1
#=GS E3FYX9_STIAD/15-230 AC E3FYX9.1
#=GS Q132G5_RHOPS/5-230 AC Q132G5.1
#=GS C5Z189_SORBI/104-329 AC C5Z189.1
#=GS B4MN78_DROWI/13-128 AC B4MN78.1
#=GS A7H6F0_ANADF/4-211 AC A7H6F0.1
#=GS F8IR95_STREC/8-215 AC F8IR95.1
#=GS C5ZKA4_BURPE/12-230 AC C5ZKA4.1
#=GS C8KG69_LISMN/3-218 AC C8KG69.1
#=GS B8CT45_SHEPW/7-224 AC B8CT45.1
#=GS D4IW36_BUTFI/3-78 AC D4IW36.1
#=GS D6L950_9FUSO/4-224 AC D6L950.1
#=GS B7LY59_ECO8A/8-224 AC B7LY59.1
#=GS G5JNH0_STRCG/5-209 AC G5JNH0.1
#=GS B4J0B5_DROGR/35-252 AC B4J0B5.1
#=GS Q5BIC6_DROME/26-244 AC Q5BIC6.1
#=GS F5NTQ7_SHIFL/4-220 AC F5NTQ7.1
#=GS A5MNC7_STRPN/4-209 AC A5MNC7.1
#=GS C9B069_ENTCA/3-217 AC C9B069.1
#=GS Q0A4Z8_ALHEH/104-237 AC Q0A4Z8.1
#=GS F6CCJ9_LACKZ/4-219 AC F6CCJ9.1
#=GS E6GR80_ENTFL/4-220 AC E6GR80.1
#=GS C7KWC3_ACEPA/6-221 AC C7KWC3.1
#=GS F7MDA1_9FUSO/4-218 AC F7MDA1.1
#=GS F3VY01_SHIBO/1-135 AC F3VY01.1
#=GS C9VMY3_BRUAO/11-229 AC C9VMY3.1
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