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Database: Pfam
Entry: Peptidase_C70
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#=GF ID   Peptidase_C70
#=GF AC   PF12385.3
#=GF DE   Papain-like cysteine protease AvrRpt2
#=GF AU   Coggill P
#=GF SE   MEROPS_C70.001
#=GF GA   18.80 18.80;
#=GF TC   18.80 18.80;
#=GF NC   18.70 18.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10361296
#=GF RT   Characterization of the Pseudomonas syringae pv. tomato AvrRpt2
#=GF RT   protein: demonstration of secretion and processing during
#=GF RT   bacterial pathogenesis.
#=GF RA   Mudgett MB, Staskawicz BJ;
#=GF RL   Mol Microbiol. 1999;32:927-941.
#=GF RN   [2]
#=GF RM   18705889
#=GF RT   Papain-like cysteine proteases: key players at molecular
#=GF RT   battlefields employed by both plants and their invaders.
#=GF RA   Shindo T, Van der Hoorn RA;
#=GF RL   Mol Plant Pathol. 2008;9:119-125.
#=GF DR   INTERPRO; IPR022118;
#=GF DR   MEROPS; C70;
#=GF CC   This is a family of cysteine proteases, found in actinobacteria,
#=GF CC   protobacteria and firmicutes. Papain-like cysteine proteases
#=GF CC   play a crucial role in plant-pathogen/pest interactions. On
#=GF CC   entering the host they act on non-self substrates, thereby
#=GF CC   manipulating the host to evade proteolysis [2]. AvrRpt2 from
#=GF CC   Pseudomonas syringae pv. tomato DC3000 triggers resistance to P.
#=GF CC   syringae-2-dependent defence responses, including hypersensitive
#=GF CC   cell death, by cleaving the Arabidopsis RIN4 protein which is
#=GF CC   monitored by the cognate resistance protein RPS2 [1].
#=GF SQ   20
#=GS E1VLS9_9GAMM/270-416    AC E1VLS9.1
#=GS A5IGQ0_LEGPC/1207-1371  AC A5IGQ0.1
#=GS G4T2X2_META2/19-164     AC G4T2X2.1
#=GS A1TIM5_ACIAC/71-235     AC A1TIM5.1
#=GS E5B9B2_ERWAM/1-130      AC E5B9B2.1
#=GS Q1WEM6_ERWAM/41-215     AC Q1WEM6.1
#=GS A0NME8_9RHOB/144-240    AC A0NME8.1
#=GS Q5WYP2_LEGPL/1207-1371  AC Q5WYP2.1
#=GS E1Y144_LEGPN/1207-1371  AC E1Y144.1
#=GS Q2SFG4_HAHCH/277-427    AC Q2SFG4.1
#=GS B1FR68_9BURK/594-748    AC B1FR68.1
#=GS ARPT2_PSEUB/67-250      AC Q6LAD6.1
#=GS E1VLS9_9GAMM/49-218     AC E1VLS9.1
#=GS E2MMQ4_PSEUB/67-250     AC E2MMQ4.1
#=GS Q395Y8_BURS3/6-153      AC Q395Y8.1
#=GS B1TGB7_9BURK/629-782    AC B1TGB7.1
#=GS F0Q2R3_ACIAP/1-163      AC F0Q2R3.1
#=GS D4IEP4_ERWAE/41-215     AC D4IEP4.1
#=GS D5T9P4_LEGP2/1207-1371  AC D5T9P4.1
#=GS D4I1J6_ERWAC/41-215     AC D4I1J6.1
E1VLS9_9GAMM/270-416               ...................................ftaalaaqqrarqlsnt--------.........--------------Ldv........cynVELVPQQT-G.MSCWAAGFAMIVGWRD...R.....-..V..........SINPEEI..ARA-S...G.HWAQYQS..GLNP..........EDVSVMQVW.GF.VPEP.......P-QS....YMISAFANLLRRYGPLWVA...SAEP..GP-.---..HIRVI..TGIRG...D...G......-..-------..-..-------..-----..-------.--tpdgttlyindpweqgmts..........
A5IGQ0_LEGPC/1207-1371             ..........................kvntkfdggttspaietkigkggitp--------.........---------------.............---MKQENS-.NACWATVATMMLRWKD...S.....K..Nytie..evltKAGSQYLnyYKQKT...G.LPY----..-TEK..........QNFITSLGM.RG.--EP.......L-AN....YTAQNYRDWLVEYGPLWVT...TDTD.qSKG.FSA..HALII..TGISS...D...L......K..SLEVIDP..L..QGRKFVQ..SFEEF..ANA----.--fke..........................
#=GR A5IGQ0_LEGPC/1207-1371  pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
G4T2X2_META2/19-164                ...........................................igkhhgrdd--------.........---------------.............---------P.TGCWYASLCMVGFYFE...A.....G..P..........RLGNPEL..FKRP-...-.LD-KLKH..GTDVghfpiggdaeLKMMQNEGL.EE.VPEP.......ADKK....WKNWQLAKMLKEYGPLMMS...WWAP..G--.--A..HVSVV..IGIDS...E...A......N..EVIYHDP..E..NAPNSRM..SLNNF..NSKLMWG.--nr...........................
#=GR G4T2X2_META2/19-164     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
A1TIM5_ACIAC/71-235                ..................................................rt--LGGGHF.........QSAGSSSSSGGSKLV.............VPYIPQNGTR.-GCWEATMNMLRAYFG...Q.....P..Pl........dKGQLAYL..YDA-E...G.VPKELNG..PLDY..........ATRNRKAKL.KN.IPVP.......AGKS....WDADKIRALLDQHGPLEAR...IESP..NDE.LVA..HAIVL..TGIDE...D...G......D..VIC-HDP..E..LGPGQKV..SIAML..NAAFDWS.SH.............................
#=GR A1TIM5_ACIAC/71-235     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
E5B9B2_ERWAM/1-130                 ....................................................--------.........---------------.............----------.MGCWYACTRMLGHSIS...S.....G..P..........RLGLPEL..YDS-S...G.-PQGLQQ..REDV..........LRLMRNENL.AE.VSLP.......ESRQ....FSANELGNLLCRHGPIMFG...WQTP..AGS.W--..HMSVL..TGIDK...P...N......D..AIIFHDP..Q..RGPDLTM..PLDSF..NQRLVWRvPH.............................
#=GR E5B9B2_ERWAM/1-130      pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
Q1WEM6_ERWAM/41-215                ....................................................APSFGGCFgkskksrgyDSGSSSGSRSNAGFRl..........nhVPYVSQQNER.MGCWYACTRMLGHSIS...S.....G..P..........RLGLPEL..YDS-S...G.-PQGLQQ..REDV..........LRLMRNENL.AE.VSLP.......ESRQ....FSANELGNLLSRHGPIMFG...WQTP..AGS.W--..HMSVL..TGIDK...P...N......D..AIIFHDP..Q..RGPDLTM..PLDSF..NQRLAWRvPH.............................
#=GR Q1WEM6_ERWAM/41-215     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
A0NME8_9RHOB/144-240               .....................................ggalriplgqtqwqd--------.........---------------.............----------.----------------...-.....-..-..........-------..-----...-.-------..----..........-----RLGL.TP.IEEP.......F-EN....FYAEICASRLQQHGPLLLG...VFRE..RGR.V-G..HVVVMwgAGVTG...S...D......A..GIQVMDP..A..RTPNSR-..-----..-------.--flriagiqagdf.................
Q5WYP2_LEGPL/1207-1371             ..........................kvntkfdggttspaietkigkggitp--------.........---------------.............---MKQENS-.NACWATVATMMLRWKD...S.....K..Nytie..evltKAGAQYLnyYKQKV...G.LPY----..-TEK..........QNFITSLGM.KG.--EP.......I-AN....YTAQNYRDWLVEYGPLWVT...TDTD.qSEG.FSA..HALII..TGISS...D...L......K..SLEVIDP..L..QGRKLVQ..SFDEF..ANAF---.--ke...........................
#=GR Q5WYP2_LEGPL/1207-1371  pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
E1Y144_LEGPN/1207-1371             ..........................kvntkfdggttspaietkigkggitp--------.........---------------.............---MKQENS-.NACWATVATMMLRWKD...S.....K..Nytie..evltKAGSQYLnyYKQKI...G.LPY----..-TEK..........QNFITSLGM.KG.E--P.......L-AN....YTAQNYRDWLVEYGPLWVT...TDTD.qSEG.FSA..HALII..TGISS...D...L......K..SLEVIDP..L..QGRKLVQ..SFDEF..ANAF---.--ke...........................
#=GR E1Y144_LEGPN/1207-1371  pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
Q2SFG4_HAHCH/277-427               .........................rafdytdalaahrqamamnqsfdvryn--------.........---------------.............VQLVPQQTGF.-SCWAAGFAMIVGWRE...Q.....M..-..........SIDPSEI..ARA-V...G.YWSQYQN..GLHP..........EDL-RVMNV.WG.FTAE.......APQS....YTIEAFVNLLRNYGPLWIA...TAEP..GP-.---..HIRVV..TGIHG...D...Gtp..dgT..ILHINDP..-..-------..-----..-------.--weqgmss......................
#=GR Q2SFG4_HAHCH/277-427    pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
B1FR68_9BURK/594-748               ................rgffgmsqalsvapgaaralgaddwtvnwdevqmtp--------.........---------------.............------QPTD.MGCWATAASMVLGWRD...N.....Q..-..........SVDPALL..ARC-I...S.LERQMRD..GLAP..........AEVAGFAGA.ST.LTVE.......PNAC....FAPEGFRRLLEANGPIWVAe.vVRAP..VNF.F--..HAVVV..TGMYR...S...G......D..A------..-..-------..-----..-------.--yfvritdpldrv.................
ARPT2_PSEUB/67-250                 ....................................................VPAFGGWFkkk..sskhETGGSSANADSSSVAsdstekplfrlthVPYVSQGNER.MGCWYACARMVGHSVE...A.....G..P..........RLGLPEL..YEGRE...G.-PAGLQD..FSDV..........ERFIHNEGL.TR.VDLP.......DNER....FTHEELGALLYKHGPIIFG...WKTP..NDS.W--..HMSVL..TGVDK...E...T......S..SITFHDP..R..QGPDLAM..PLDYF..NQRLAWQvPH.............................
#=GR ARPT2_PSEUB/67-250      AS    ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
E1VLS9_9GAMM/49-218                ........................sraqgfsstakhsraftsirydipgefq--------.........---------------.............---VLAQPSS.MACWATVFTMLKSWRS...Q.....R..GmtieqatasvGQRWLDL..YRADT...G.LSG----..-DDK..........VNFISTAGL.VA.-EPP.......Q--S....YSIQGWETLLRNYGPIWVT..tDEAP..GKA.WAI..HARII..TGIYG...D...G......-..-------..-..-------..-----..-------.--tpegtcfkivdpaggrryeesiavfipky
E2MMQ4_PSEUB/67-250                ....................................................VPAFGGWFkkk..sskhETGGSSANADSSSVAsdstekplfrlthVPYVSQGNER.MGCWYACARMVGHSVE...A.....G..P..........RLGLPEL..YEGRE...G.-PAGLQD..FSDV..........ERFIHNEGL.TR.VDLP.......DNER....FTHEELGALLYKHGPIIFG...WKTP..NDS.W--..HMSVL..TGVDK...E...T......S..SITFHDP..R..QGPDLAM..PLDYF..NQRLAWQvPH.............................
#=GR E2MMQ4_PSEUB/67-250     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
Q395Y8_BURS3/6-153                 ................................................lnvp--MV----.........DQSGVKKTKSGSKAL.............---------K.NACWYAAACMVSYFHR...P.....G..P..........RLGIPAL..WRADQ...G.LPS----..-SRI..........PDLCAVEGL.MA.LNQP.......T--V....ITPEWLAAVLTEFGPIWAAgkfLDRPdeSDD.EIG..HVIVI..TGIRH...-...-......G..MVHYNDP..E..GPPVRTM..LLSTL..DTG----.--rht..........................
#=GR Q395Y8_BURS3/6-153      pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
B1TGB7_9BURK/629-782               .................gffgmsqalsvapgtarafgaddwtvnwdevqmtp--------.........---------------.............------QPTD.MGCWATAASMVLGWRD...N.....Q..S..........-VDPALL..ARC-I...S.LERQMRD..GLAP..........AEVAGFAAA.SS.LTVE.......PNAC....FAPEGFRRLLEANGPIWVAe.vVRAP..VNF.F--..HAVVV..TGMYR...S...G......D..A------..-..-------..-----..-------.--yfvritdpldrv.................
F0Q2R3_ACIAP/1-163                 ....................................................--MGGGHL.........QSAGSCSSSGGSKLA.............VPYIPQNGTR.-GCWEATMNMLRAYFG...Q.....P..Pl........dKRQLAYL..YDA-E...G.VPKELNG..QLDY..........ATRNRKAKL.KN.VPVP.......AGKS....WDADKIKALLDQHGPLEAR...IESP..HDE.LVA..HAIVL..TGIDE...D...G......D..VIC-HDP..E..LGPRQKV..SIEML..NAAFDWT.SH.............................
#=GR F0Q2R3_ACIAP/1-163      pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
D4IEP4_ERWAE/41-215                ....................................................APSFGGCFgkskksrgyDSGSSSGSRSNAGFRl..........nhVPYVSQQNER.MGCWYACTRMLGHSIS...S.....G..P..........RLGLPEL..YDS-S...G.-PQGLQQ..REDV..........LRLMRNENL.AE.VSLP.......ESRQ....FSANELGNLLCRHGPIMFG...WQTP..AGS.W--..HMSVL..TGIDK...P...N......D..AIIFHDP..Q..RGPDLTM..PLDSF..NQRLAWRvPH.............................
#=GR D4IEP4_ERWAE/41-215     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
D5T9P4_LEGP2/1207-1371             ..........................kvntkfdggttspaietkigkggitp--------.........---------------.............---MKQENS-.NACWATVATMMLRWKD...S.....K..Nytie..evltKAGSQYLnyYKQKT...G.LPY----..-TEK..........QNFITSLGM.RG.--EP.......L-AN....YTAQNYRDWLVEYGPLWVT...TDTD.qSKG.FSA..HALII..TGISS...D...L......K..SLEVIDP..L..QGRKFVQ..SFEEF..ANA----.--fke..........................
#=GR D5T9P4_LEGP2/1207-1371  pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
D4I1J6_ERWAC/41-215                ....................................................APSFGGCFgkskksrgyDSGSSSGSRSNAGFRl..........nhVPYVSQQNER.MGCWYACTRMLGHSIS...S.....G..P..........RLGLPEL..YDS-S...G.-PQGLQQ..REDV..........LRLMRNENL.AE.VSLP.......ESRQ....FSANELGNLLCRHGPIMFG...WQTP..AGS.W--..HMSVL..TGIDK...P...N......D..AIIFHDP..Q..RGPDLTM..PLDSF..NQRLAWRvPH.............................
#=GR D4I1J6_ERWAC/41-215     pAS   ..............................................................................................................*...................................................................................................................................................*.................................*.............................................................
#=GC seq_cons                      ...................................................s................................................h.Qpspt..uCWhAsssMlhtahc...s.....t..s..........+lG.s.L..Ycu.p...G.hPtthpt...p-h..........tchhpstuL.ps.ls.P.......tsps....aospphtsLLpcaGPlhhu...hcoP..uss.a....HshVl..TGIcp...-...s......c..ul.hhDP.....pG.p.h...shp.h..spt....................................
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