GenomeNet

Database: Pfam
Entry: Peptidase_M44
LinkDB: Peptidase_M44
Original site: Peptidase_M44 
#=GF ID   Peptidase_M44
#=GF AC   PF03410.10
#=GF DE   Metallopeptidase from vaccinia pox
#=GF PI   Protein_G1; 
#=GF AU   Finn RD
#=GF SE   Pfam-B_4417 (release 6.6)
#=GF GA   25.00 25.00;
#=GF TC   667.90 667.10;
#=GF NC   20.10 19.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR005072;
#=GF DR   MEROPS; M44;
#=GF CC   This is a family of Poxviridae metalloendopeptidases. The
#=GF CC   members were often originally named as G1 proteins. The family
#=GF CC   carries three zinc-binding ligands and a catalytic glutamate.
#=GF CC   The first two zinc ligands are histidine residues, found
#=GF CC   together with the catalytic glutamate in a HXXEH motif, an
#=GF CC   inverse of the classical metallopeptidase motif, HEXXH. The
#=GF CC   third zinc ligand is a glutamate C-terminal to the HXXEH motif
#=GF CC   within a motif ELENEY (see MEROPS).
#=GF SQ   11
#=GS Q6TUW3_YMTV5/1-588  AC Q6TUW3.1
#=GS Q6TVT3_ORFSA/1-598  AC Q6TVT3.1
#=GS MP44_RFVKA/1-589    AC Q9Q926.1
#=GS Q08FU3_DPV83/1-596  AC Q08FU3.1
#=GS Q8V3P7_SWPV1/1-592  AC Q8V3P7.1
#=GS G1_VACCW/1-591      AC P16713.2
#=GS MP44_MYXVL/1-589    AC Q9Q8Q1.1
#=GS MP44_MCV1/1-592     AC Q98224.1
#=GS Q070H9_CPRVZ/1-633  AC Q070H9.1
#=GS G1_VAR67/1-591      AC P32991.1
#=GS MP44_FOWPN/1-625    AC Q9J5D0.1
Q6TUW3_YMTV5/1-588             MIVLSNGVRIFINDDMNKDIYLGVASFGFENDIGE.ILGVAHLLEHILISFDSSKFIANASTARKYMSFWCCSIKGKSsYIDSVNTLISWFFINN.KLRDSFLLSNVKNHIKELENEYYFRNEVFHCMDVLTFLENGDLYNGGRIDMLNNLEDVNNMLCNRMKKIIGPNIVIFVKELNKTCLNMLQNSFGTLPSCPMLFSL.PTFSNIEGKIIMMPSPFYTVMIKISLSISNVISIICLFKTYHLIDYETVGNDLYITLSFVKENDYENFINGVST....LKFdDVTDYSFFSL.CDDFLMNIYLCFPWLSHDITDYLTTVKC-TRKMFKSLEDDIRDSLRSKKYVVVYPHFSKTVFNKNDRQMHKIVIL.........DCLN---------SLNNELPRl..sVNL..........................MKKQTK.NKILIKYNDSSLIKYVNF.....AIG.YKHK-IL...KENEGVCIHHQFSSEDISSILESDTFLKYNKSKPGAMYQYLLLSFFVSGYSIEDILLNRESTVKL..LRQYNN..KILFGKKAGTTLTTKSNFVGGLLKSKDIRNNIMTSIMWELKKMGLIYSMEHTKI-DKKIFYIFMFTIYPDDVFSYFS--KKFLSHCLVVSKKG...PIDDFSSIKKDVIIKL..
#=GR Q6TUW3_YMTV5/1-588  pAS   ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Q6TVT3_ORFSA/1-598             MIVLENGVRVFLRPSMKRDVYLGISNFGFGRDVGA.VLGLAHLLEHVLISFDHRFFLANASTSRNYMSFWCKSRRNRP.-ADAVRELASWFFDGG.GLRTNFENVDIRAYAKELENEYYFRNEVLHCFDVLTFLGGGDLYNGGRFADLVTTPDLPARMRERMLSISGPSVVVFLRQSNAATVALLNATFGRLPRTPEVIFP.RAVACEGGKAVMMATPFYSILARVHASLDNALAVLALRELYHLFDYETVGEDLFVVLSFVDESDYDGLLRGIKD....LPI.AATPDTRICFdAEDYAMNAYLNFPWMAHDILDYENYFVENAERLVAGLKRDVLHAISERDCVVLYPGFTSSIFNAEDAQRHRLVMI.........DLPPESPGDKMRRRSHNDGAP....ARL..........................MRKTRTpGNVLVRFGDADLLNFVTL.....ALSmHADARLF...HTFEGIRLQHRLAAEDMDAIMDSDAFMKFSKSRPAVAYQYMFLDFFASERSMEDIVENRAA----..ARRAAGapHLVFGRNTRYDVVACSSFVCGVLKGRALRADHIDALMWRMKKLGVIYSMDHTPLKSPHTFYVFAFSLSQEEAFRCIARCPHVTSYCLVVARRG...VADDFSGVSKKVVLRM..
#=GR Q6TVT3_ORFSA/1-598  pAS   ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
MP44_RFVKA/1-589               MIVFDNGVRVFINTSTNKDIYVGISGFGFEKDIGG.ILGTAHLLEHILISFDVSRFIANASTARSYMSFWCTSIRGRStPVDAIRTLISWFFDRD.GLKHYFPVSKIKYHIKELENEYYFRNEVFHCMDALTFLANGDLYNGGRLSMLDRLDDMPLILQDRMCAITGPNIVIFVRELNDVVLSLLVSTFGTLPSCPLTIPC.TLPTPIGGKIIMMPSPFYTVMVRVQPSLYNILSILCLYEIYHLVDYETVNNKLYVTISFIHEHEYESFLHGSAR....LNF.TIYKKIRLHY.GDDFLMNMYLSFPCIRHDIFDYLTIINTNVSTMIPSLEQNIYQSIKTGDYIVVYPNFSNTMSNVADRQLHKTVVI.........DTNIVYVTKPT--------TV....IDL..........................MKKHTH.NDMYIKYSDTEFIDYVQL.....ALG.LRRK-IH...KNVNGIHIRHQFSADDIKTILESETFMKYSKSKPAAMYQYLILSFFVSGNTIEDILQHRESVIKL..CRTYKN..KILLGKQTRYDIQTLSSFVCGIFKGPSITSEYLTDIMWKLKRKGLIYSLEFVEL-QKNMFYLFMFTIYPEDVTSYLTSRKLFTSRCVVVSKKC...NVEDFSSMKKDIIIKL..
#=GR MP44_RFVKA/1-589    AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Q08FU3_DPV83/1-596             MIVLSNGVRIFINPYMIKDIYLGIASFGFENDIGN.ILGVAHLLEHILISFDSSKYVANASTARSYMSFWCNSIKGRSnRLDAIKTLISWFFTGNgRIKDIFTPTKIKDHIKELENEYYFRNEIFHCMDVLTFLSDGDLYNGGRIDMINDIDTLENILYSRMHRIIGPNTIIFIKELDEETLSLLSNTFGKLPSCPLTIPC.NSFSSIVGKVVMMPSPFYTVMVNVKQSLENILAIMCLYEIYHLIDYETVGDQLYITISFVKEHEYDNFLKGVSM....LKF.-IPDEIKFNH.SDDFLMNLYLCFPWIKNDIFDYIVDVNNNMLNMFKSLEDEIYTSIRYGKYISIYPNFSKSIFNKTDRQKHKIVVL.........DCKIDHENKDSSNIINNN---....IYL..........................MKKQMInNEIHIKYGDKAFIDYAIL.....GIM.YKNNKIF...KSNHGINIHHQFSSDDINTILESDTFLKYSKSKPAAIYQYLILSFFVSGNSIEDILSKRESTINF..CKDYKN..KILFGKQLRYDIKTNSSFVCGIVKGSSISNETLTNLMWSLKKKGLIYSLEFTKL-DKKIFYIFMFTIYPEDVFKIITSNKMFNRHCIVVSNKS...DIEDFSSLKKDIIIKI..
#=GR Q08FU3_DPV83/1-596  pAS   ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Q8V3P7_SWPV1/1-592             MIVLSNGVRIFIDNSMHKDIYLGISRFGFENDIYE.VLGIAHLLEHILIDFDSSKFIANASTARSYMSFWCNSIKGKStFLDSVKRLISWFFYKD.KIRDSFSISKIKYHIKELENEYYFRNEVFHCMDVLTFLIDGDLYNGGRISMLNNINDISIMLHNRMHRIIGPNIIIFVKDINDYVLSILEKSFGSLPSCPLTIPY.MMSSHITGKIIMMPSPFYTIMINIKSTLDNILSIMCLYEIYHLIDYETVGDQLYITISFIDEKDYESILKGISR....IRL.HIDREIMMKH.TDDFLMNIYLCFPWIRNDIIDYWTDINYNIDTMLQSLNEEIYMSILQGEYIAIYPNFSDIIFNTKDRQMHKLVIM.........DTDINNSIN----NQHTQPNY....INL..........................MKKQTY.NEIYIKYGDTDFIDYVNL.....ALG.FKHT-IQ...RNNDGIKIRHQFSSDDIRTILESDVFLKYSKSKPAAMYQYLMLSFFVSGNTIEDILSNRESVLRL..CKKYNN..KIIFGKRTRYDIQTYSSFVCGIVKG-SITNELLTNMMWSLKKKGLIYSLEFTKL-KTNIFYIFMFTIYPDDVFKYVSSKQYFKSYCIVVSNKG...DYEDFSSMKKDIVIKL..
#=GR Q8V3P7_SWPV1/1-592  pAS   ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
G1_VACCW/1-591                 MIVLPNKVRIFINDRMKKDIYLGISNFGFENDIDE.ILGIAHLLEHLLISFDSTNFLANASTSRSYMSFWCKSINSAT.ESDAIRTLVSWFFSNG.KLKDNFSLSSIRFHIKELENEYYFRNEVFHCMDILTFLSGGDLYNGGRIDMIDNLNIVRDMLVNRMQRISGSNIVIFVKRLGPGTLDFFKQTFGSLPACPEIIPS.SIPVSTNGKIVMTPSPFYTVMVKINPTLDNILGILYLYETYHLIDYETIGNQLYLTVSFIDETEYESFLRGEAI....LQI.SQCQRINMNY.SDDYMMNIYLNFPWLSHDLYDYITRINDDSKSILISLTNEIYASIINRDIIVIYPNFSKAMCNTRDTQQHPIVVL.........DATNDGLIKKPYRS-------....IPL..........................MKRLTS.NEIFIRYGDASLMDMITL.....SLS.KQDISLK...RNAEGIRVKHSFSADDIQAIMESDSFLKYSRSKPAAMYQYIFLSFFASGNSIDDILANRDSTLEF..SKRTKS..KILFGRNTRYDVTAKSSFVCGIVRGKSLDKTSLVEMMWDLKKKGLIYSMEFTNLLSKNTFYLFTFTIYTDEVYDYLNTNKLFFAKCLVVSTKG...DVENFSSLKKDVVIRV..
#=GR G1_VACCW/1-591      AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
MP44_MYXVL/1-589               MIVFDNGTRVFINSSTNKDIYVGFSGFGFEKDIGG.ILGIAHLLEHILISFDASRFVANASTARSYMSFWCTPIRGRAtSVDAVRTLISWFFDKD.GLKDDFPVSKIKYHIKELENEYYFRNEVFHCMDALTFLANGDLYNGGRLSMLDRLEDIPLILRDRMRTIIGPNVVIFVRELNDVVLSLLANTFGRLPACPLTIPC.TVRTIIGGKTIMMPSPFYTVMVRVEPSLHNILSILCLYEIYHLVDYETVDNKLYVTFSFIHEHDYERFLQGSGR....LNL.TIYKKIRLCY.GDDFLMNVYLSFPCIRHDIFDYLTIVNTDTSSMISSLERDIYQSVRTGDYIVVYPNFSNTMSNTADRQLHKTVVI.........NPNIVYASQPTTS--------....IDL..........................MKKQTH.NEMYIKYSDAGFIDYVQL.....ALG.LRRK-IH...KHVHGIHIRHQFSADDIKTILESDTFMKYSKSKPAAMYQYLILSFFVSGNTIEDILQHRESVVKL..CRTYKN..KIVLGKQTRYDIQTLSSFVCGIFKGPSVTSEYLTDIMWKLKRKGLIYSLEFVEL-QKNMFYLFMFTIYPEDVTTYLSSRKLFTSRCVVVSKKG...NTEDFSSMKKDIIIKL..
#=GR MP44_MYXVL/1-589    AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
MP44_MCV1/1-592                MILLENGVRVFPKPGMGKDIYIGLANFGFENDVPE.LLGVAHLLEHILISFDYTRFVANASTARTYMSFWCRALRAED.YLAALETAVSWFFARG.ALRTDFSRVRIRNYVRELENEYYFRNEVFHCMDILTFLGGGDLYNGGRLSMLEQLDAVRELLGKRMRRLAGPNVVIFVRELSPAALALLERSFGTLPRFPSTIPA.TRLGSIHNKAVLVPAPFYALLIQVDNTVENVLAVICLAESYHFVDYETLGERLYVSFAFVHEQDCEAFLRNVGE....LRF.EPAPRVELNY.SDDYVMNLYVNFPWLQHDLADYLYTLNADCVPLLRGLEENLRRSVRERQLVVVYPSFSPSLFNSRDRQDHRLLVL.........DVDLARSAGPARV--------....PRT..........................FRRQPR.AEVFVRYGDPALLDYVAF.....ALArPRAAALR...RLPRGVRLAHGFSHADMHEIMASETFIKYSRSRPAALFQYIFLAFFATGRSIAEILERREALVSF.dARRCVN..RLVFAKRARYDVVTKSSFVCGVLRGPRLSEAALTRAMWELKRKGLLYSLEHTRMHAKHTFYVFAFSIYPEQVYRYFARWQLVSKHCCVVSMRG...EREDYSALRKEVVVN-f.
#=GR MP44_MCV1/1-592     AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Q070H9_CPRVZ/1-633             MILLSNGVRVFLMPEMRKDIYVGIANFGFERDIDD.VLGISHLLEHILIDFDHERFAGNATTSRTYMSFWCCALRGAT.YMDAVRTTVSWFFGPDgRLRTNFQRVPVENFVRELENEYYFRCESFHCFDVLTYLGGGDLYNGGRATMLRDLPRVRRLLGRRMRAISAHGVVIFVRHMNREVFALIDATFGRLPAYPALIGP.DR-GVSGNKIVFTPSPFFTVYVRVPNTIENLIALCCVSSVYLFVNYETVLGELYVSVSFVDEDGYEDFVNDVFSenpgNRF.DEYGVANFTY.GDDDLMALYLNFPSVQRDLTEYVYYCYRRHRQLIDALWRDLAAAARRRDVIIIYPSFAEPLFNAVDGQRHRLLLA.........DIRPSDPAPAGAPRPGEAGAP....AEAeagapilpprladdggrplarrrawpRRAAAR.QSVTVPYRHSHYLDYAALfgalaRLK.LGRVELR...RDGRGLSLRHDLAQADLDKVFTADAFVRYRNSKPALLYIDIFLAYFASGRSIEAILSNTDA-LSFisARDDKI..NLKFGRNKAYRITTRSSFVCGVVRGKRVSQCLISRFMWDLKRLGYLYNLECVKI-LPRTYYLFAFSVCPESILRYLAAALKGEKFCFVVSTRG...AEEDFSALKKRTTV--al
#=GR Q070H9_CPRVZ/1-633  pAS   ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
G1_VAR67/1-591                 MIVLPNKVRIFINDRMKKDIYLGISNFGFENDIDE.ILGIAHLLEHLLISFDSTIFLANASTSRSYMSFWCKSINSAT.ESDAIRTLVSWFFSNG.KLKDNFSLSSIRFHIKELENEYYFRNEVFHCMDILTFLSGGDLYNGGRIDMIDNLNIVRDMLVNRMQRISGSNIVIFVKRLGPGTLDFFNQTFGSLPACPEIIPS.SIPVSTNGKIVMTPSPFYTVMVKINPTLDNILGILYLYETYHLIDYETIGNQLYLTVSFIDETEYESFLRGEAI....LQI.SQCQRINMNY.SDDYMMNIYLNFPWLSHDLYDYITRINDDSKSILISLTNEIYTSIINRDIIVIYPNFSKAMCNTRDTQQHPIVVL.........DATNDGLIKKPYRS-------....IPL..........................MKRLTS.NEIFIRYGDASLMDMITL.....SLS.KQDISLK...RNAEGIRVKHSFSADDIQAIMESDSFLKYSRSKPAAMYQYIFLSFFASGNSIDDILTNRDSTLEF..SKKTKS..KILFGRNARYDVTTKSSFVCGIVRGKLLDKTSLVEMMWDLKKKGLIYSMEFTNLLSKNTFYLFTFTIYTDEVYDYLNTNKLFSAKCLVISTKG...DVENFSSLKKDVVIRV..
#=GR G1_VAR67/1-591      AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
MP44_FOWPN/1-625               MIQLNNGIRIFVNHSMKKDIYIGISDFGFEKDINDgILGIAHLLEHILISFDNKYFNANASTSRTYMSFWCVALQKRH.YEDAIRTAISWFFDKKyILKTDFSRIVLENYITELENEYYYRTEMYHCMDVLAYLYGGDLYNGGRITMLERLPEIRNMLSNRMKFLSGKNIVIFVKRLTNNILTLLTNTFGSIPKYPIIIPLdPQIQDARRKIIMMPCPFYTLLIQVDNTMNNLLAIICLVENYNLIDYETISDKLYVCISFANEDQYEYLLYNIKD....MDF.-NINRIELDL.GEDYIMNLYINFPWLKNDIFEYIHTMNTKSAMLLADLKKNMHNSILEHKFMIIYPSFTKLLYNITDKQNHGILVVgdvsftpekDPSMHHSNKENNNNYSKTVTKrkskYVM..........................YRKTPTtNNIVIDYTDSSFFDYATFy..hvMKSkYEKTNLFsrlKTSTGMCYKHCFDNDDLNELINSDTFIRYNSSKPAVLYQYILLAYFVTERDIKELVDYKDA-IEL.dMKYYSK.nKILFGKNTRYDIRTKSMFVCGLIKGRKLSEKVITDYMWKLKSLGLIYYLTSIKLGISNTFYIFAFTIFPEKVYNFFVGLKEITNRCLIVSNKNtkiEEDDYSSLNKQIVI--gi
#=GR MP44_FOWPN/1-625    AS    ............................................*.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
#=GC seq_cons                  MIVLsNGVRlFINssMpKDIYlGISsFGFEpDIs-.ILGlAHLLEHILISFDso+FlANASTuRoYMSFWCsSI+u+o..hDAlRTLlSWFFsps.tL+csFshopI+.HIKELENEYYFRNEVFHCMDlLTFLusGDLYNGGRlsMLcsLsclpphLtsRM+pIsGPNlVIFV+cLssssLuLLssTFGoLPuCPhhIPs.sh.sshsGKIlMMPSPFYTVMl+VpsoL-NlLuIlCLaEhYHLlDYETVGscLYlTlSFlcEp-YEsFL+Glup....Lph.s.spcIphsa.uDDalMNlYLsFPWlpHDIhDYlsplNssspshltSLcc-IapSIpp+-hIVlYPsFScslaNspD+QpH+lVVl.........Dss.stssp.s..p...........lsL..........................MKKpsp.N-laI+YuDuuhlDYlsL.....uLu.hccttlp...+sscGI+l+HpFSuDDIpsIhESDoFlKYS+SKPAAhYQYlhLSFFsSGpSIEDILppR-Sslch..s+chps..KIlFGKpsRYDlpTpSSFVCGllKGpslopphLTchMWcLK+KGLIYSLEaTcL.pKphFYlFhFTIYPE-VacYlsspKhFsu+ClVVSpKG...shEDFSSlKKDllI+l..
//
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