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Database: Pfam
Entry: Peptidase_S7
LinkDB: Peptidase_S7
Original site: Peptidase_S7 
#=GF ID   Peptidase_S7
#=GF AC   PF00949.20
#=GF DE   Peptidase S7, Flavivirus NS3 serine protease 
#=GF PI   Flavi_helicase; 
#=GF AU   Finn RD
#=GF SE   Pfam-B_199 (release 3.0)
#=GF GA   20.00 20.00;
#=GF TC   20.00 20.00;
#=GF NC   19.90 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7642575
#=GF RT   Association between NS3 and NS5 proteins of dengue virus type 2
#=GF RT   in the putative RNA replicase is linked to differential
#=GF RT   phosphorylation of NS5. 
#=GF RA   Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE,
#=GF RA   Padmanabhan R; 
#=GF RL   J Biol Chem 1995;270:19100-19106.
#=GF RN   [2]
#=GF RM   2174669
#=GF RT   Flavivirus genome organization, expression, and replication. 
#=GF RA   Chambers TJ, Hahn CS, Galler R, Rice CM; 
#=GF RL   Annu Rev Microbiol 1990;44:649-688.
#=GF RN   [3]
#=GF RM   8269709
#=GF RT   Evolution and taxonomy of positive-strand RNA viruses:
#=GF RT   implications of comparative analysis of amino acid sequences. 
#=GF RA   Koonin EV, Dolja VV; 
#=GF RL   Crit Rev Biochem Mol Biol 1993;28:375-430.
#=GF RN   [4]
#=GF RM   10026173
#=GF RT   Dengue virus NS3 serine protease. Crystal structure and insights
#=GF RT   into interaction of the active site with substrates by molecular
#=GF RT   modeling and structural analysis of mutational effects. 
#=GF RA   Murthy HM, Clum S, Padmanabhan R; 
#=GF RL   J Biol Chem 1999;274:5573-5580.
#=GF DR   INTERPRO; IPR001850;
#=GF DR   MEROPS; S7;
#=GF DR   MEROPS; S7;
#=GF DR   SCOP; 1bef; fa;
#=GF CC   The viral genome is a positive strand RNA that encodes a single 
#=GF CC   polyprotein precursor. Processing of the polyprotein precursor
#=GF CC   into mature proteins is carried out by the host signal peptidase
#=GF CC   and by NS3 serine  protease, which requires NS2B (Pfam:PF01002)
#=GF CC   as a cofactor [4]. 
#=GF SQ   21
#=GS C5J5N2_MYCCR/18-75        AC C5J5N2.1
#=GS Y591_MYCPN/171-291        AC Q50336.1
#=GS POLG_YEFV1/1502-1655      AC P03314.1
#=GS Y586_MYCPN/154-286        AC P75194.1
#=GS POLG_ZIKV/1515-1666       AC Q32ZE1.1
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 D; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 B; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5T1V B; 82-223;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5T1V A; 82-222;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 F; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 H; 19-168;
#=GS Y580_MYCPN/2-70           AC P75200.1
#=GS C8W2Y8_DESAS/110-164      AC C8W2Y8.1
#=GS W4M1P4_9BACT/54-90        AC W4M1P4.1
#=GS Q4AA40_MYCHJ/48-227       AC Q4AA40.1
#=GS A1TVN4_ACIAC/31-106       AC A1TVN4.1
#=GS Y589_MYCPN/14-134         AC Q50338.1
#=GS A0A0K9QPV2_SPIOL/111-151  AC A0A0K9QPV2.1
#=GS Y584_MYCPN/1-69           AC P75196.1
#=GS K8DZM9_9FIRM/257-324      AC K8DZM9.1
#=GS Y577_MYCPN/197-333        AC P75203.1
#=GS POLG_DEN1W/1492-1643      AC P17763.2
#=GS POLG_DEN1W/1492-1643      DR PDB; 3LKW A; 71-218;
#=GS POLG_DEN1W/1492-1643      DR PDB; 3L6P A; 71-218;
#=GS A0A0A2TJV7_9FIRM/47-90    AC A0A0A2TJV7.1
#=GS Y298_MYCGA/335-468        AC P33276.3
#=GS A0A0U5C451_9EURO/129-185  AC A0A0U5C451.1
#=GS A0A164NVM4_9CRUS/286-438  AC A0A164NVM4.1
#=GS R6X0L4_9PORP/402-439      AC R6X0L4.1
C5J5N2_MYCCR/18-75                   ....................................................................................................................................................................................lflytkd----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....KK.....INSI...................................................N...DK.....L...Y.....VENIDF..N..D..GSSGSPLFY-KNKIVG.V..YKGKEVVQ....-----------gkltsffn.........................
Y591_MYCPN/171-291                   ...........................................................................................................................................................................................WECKQGAERFSYGYFY..SNMA.......RLTKNLR.QG------DPNAGSKTHI...EYSNELL.DKDS........M.DQGIVR.FS..TFL..G.A.NINYHD.....YD.....YRQQ...................................................G...YG.....L...T.....LTDTNL..P..G..GSSGSLVFNQDKKISS.I..YSAATESD....----SVGYAQL.................................
POLG_YEFV1/1502-1655                 ..........................................................................................................................................................................................e-HLEDGIYGIFQSTFL..GASQ.......RGVGVAQ.GGVFHTMWHVTRGAFLVR...NGKKLIP.SWAS........V.KEDLVA.YG..GSW..K.L.EGRWDG....eEE.....VQLIaavpgknvvnv.............................qtkpslfkvrnG...GE.....I...G.....AVALDY..P..S..GTSGSPIVNRNGEVIG.L..YGNGILVG....DNSFVSAISQT.................................
#=GR POLG_YEFV1/1502-1655      AS    ........................................................................................................................................................................................................................................*....................................*...............................................................................................................................*.........................................................................
Y586_MYCPN/154-286                   ...........................................................................................................................................................................................YLLGYPFLRNKAASLF.lNQTEqrkehmdKTTQILH.EKPFVVLTDPAKPTLIRN..kGANFTGN.TWTS........-.NYDLSK.KS..GLY..H.-.--KFLG.....KK.....YQIY...................................................G...KS.....I...V.....ISDLNL..S..S..GSSGSLLLNDRKQIVG.I..YFGVDGPK....---DELGFSQL.................................
POLG_ZIKV/1515-1666                  ...........................................................................................................................................................................................-ETTDGVYRVMTRRLL..GSTQ.......VGVGVMQ.EGVFHTMWHVTKGAALRS...GEGRLDP.YWGD........V.KQDLVS.YC..GPW..K.L.DAAWDG....lSE.....VQLLavppgerarni.............................qtlpgifktkdG...-D.....I...G.....AVALDY..P..A..GTSGSPILDKCGRVIG.L..YGNGVVIK....NGSYVSAITQ-g................................
#=GR POLG_ZIKV/1515-1666       SS    ...........................................................................................................................................................................................-XX-SEEEEEEEEETT..EEEE.......EEEEEEE.TTEEEE-HHHHTT--BBE...TTSEB-E.EEEE........T.TTTEEE.ES..SS-..-.-.---B-S....SS-.....EEEEE--TTS--EEE.............................EE--EEEEETTE...-E.....E...E.....EE----..-..T..TGTT-EEE-TT--EEE.E..TTBEEEBT....TS-EEEE-B---................................
#=GR POLG_ZIKV/1515-1666       pAS   ........................................................................................................................................................................................................................................*....................................*...............................................................................................................................*.........................................................................
Y580_MYCPN/2-70                      ........................................................................................................................................................................................taq----------------..----.......-------.------------------...-------.----........-.------.--..-YY..Q.L.DEKFNQ.....QT.....YEQY...................................................G...KG.....L...A.....LNDLYI..R..R..GASGSLVFNQDQQISG.I..FFAVASHS....-----------dpkpgektlvql.....................
C8W2Y8_DESAS/110-164                 ........................................................................................................................................................................vgvtlqvqiseteigwfse----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....Q...V.....VCDMNS..Q..P..GDSGSLIVNNNKKAVG.L..LFAG----....-----------sdkft............................
W4M1P4_9BACT/54-90                   ........................................................................................................................................................................................pfs----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....-...-.....------..S..G..GDSGSLIVNPARQAVG.L..LFAGTDAG....-----------vtyanpi..........................
Q4AA40_MYCHJ/48-227                  ................................................eneknltrftatlvkktnnnltfvstfhslnsiknniqqqvfdiflqqfsvknletklkskirveyenkekdiivfsldikeplllrisdsidfqvledftntknslfslgfltilnedfkpktlktlfyvndkvveld----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................K...EN.....V...F.....VQDINY..R..Q..GSSGSPLFY-KNKIVG.L..YRGKK---....-----------lkngklt..........................
A1TVN4_ACIAC/31-106                  ................................................................................................................................................................pntavchsggtsgwrcgvqkstnsqqs----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....--IN...................................................G...RT.....F...T.....LSEANFcgA..P..GDSGGPVVNAENNALG.I..YTAALGKD....-----------ltgtcga..........................
Y589_MYCPN/14-134                    ...........................................................................................................................................................................................FEWTKTEQRFNHDDFY..GSMP.......TLTKNLR.QG------QPVAGSKVHT...DYSNGFL.NEYS........L.NQGIVD.FG..TFK..S.A.ITDYHG.....YE.....YKNH...................................................G...YG.....L...A.....LTDTDL..L..G..GSSGSLVFNQDKKISS.I..YSAATESD....----SVGYAQL.................................
A0A0K9QPV2_SPIOL/111-151             .......................................................................................................................................................................................iiqc----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....-...-.....-NRLNF..R..E..GCSGSPVFNTKGEIVG.M..L-------....-----------icevnscdialh.....................
Y584_MYCPN/1-69                      ........................................................................................................................................................................................mny----------------..----.......-------.------------------...-------.----........-.-----D.LS..QKF..K.V.YLEFSG.....KK.....YRIY...................................................G...QS.....I...G.....ISHLDL..G..G..GSSGSLLLNDKKQIAG.I..YFGVDGAN....---NELGLAQL.................................
K8DZM9_9FIRM/257-324                 ................................................................................................................................................................itrgtvtavgatmevklddentayfad----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....Q...V.....VTDMKS..Q..G..GDSGSLVLNQENRAVG.L..LFAGS---....-----------dkvtvcnhi........................
Y577_MYCPN/197-333                   ..........................................................................................................................................................................................v-ESNIAALNLNQTEVK.pTRPE.......-DVAQVT.FKEPWSVDHHREIPTLTTnqlTTIKTKH.FSGS........K.LSWPFD.HT..KSF..K.I.KNKWLG.....QN.....YQMY...................................................G...HG.....L...G.....IDQVNL..R..K..GTSSSLVINQKRQIVG.I..YFATVITNp.kkAVRNDVGLVQM.................................
POLG_DEN1W/1492-1643                 ..........................................................................................................................................................................................v--LDDGIYRILQRGLL..GRSQ.......VGVGVFQ.EGVFHTMWHVTRGAVLMY...QGKRLEP.SWAS........V.KKDLIS.YG..GGW..R.F.QGSWNA....gEE.....VQVIavepgknpknv.............................qtapgtfktpeG...-E.....V...G.....AIALDF..K..P..GTSGSPIVNREGKIVG.L..YGNGVVTT....SGTYVSAIAQ-a................................
#=GR POLG_DEN1W/1492-1643      SS    ..........................................................................................................................................................................................X--XXXEEEEEEEEETT..CEEE.......EEEEEEE.TTEEEEEHHHHTT--EEE...TTEEE-E.EEEE........T.TTTEEE.ES..SS-..-.-.-----T....T--.....EEEEE--TTS--EEE.............................EE--EEEEETTE...-E.....E...E.....EE----..-..T..T-TT-EEE-TTS-EEE.E..CEEEEE-T....TS-EEEEEE---................................
#=GR POLG_DEN1W/1492-1643      pAS   ........................................................................................................................................................................................................................................*....................................*...............................................................................................................................*.........................................................................
A0A0A2TJV7_9FIRM/47-90               ........................................................................................................................................................................................ifi----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....-...-.....----QL..N..A..GNSGSPVINNQAQVVG.V..IFGVTTFE....-----------negvsesrglai.....................
Y298_MYCGA/335-468                   ...........................................................................................................................................................................................WPTTPQYTKFSVPSLS..-RRQ.......IPITSDS.RGSPGWTINALNPTELDG...QKIASST.SLSSt.....ggI.RAGIYN.AD..IAR..N.F.QLVYRN.....VK.....YKQY...................................................G...YG.....Y...I.....IQNSNL..S..A..GSSGSLALTSNNQALG.I..YFGTVSVD...aKKEATFGLVA-s................................
A0A0U5C451_9EURO/129-185             ....................................................................................................................................................................qtvyletwehtfthgrgsgkfvc----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....-...-.....------..R..P..GDSGSLVFNKDKKVVG.L..FFGGSDTQ....----DVG----yfts.............................
A0A164NVM4_9CRUS/286-438             .........................................................................................................................................................................................kl---PDGVYAINAKGLL..GSRR.......VGASVVV.RGVFHTCWRVTDSNPIVY...QERLLLP.HSTH........K.EQDIVT.YG..GPW..Q.-.-GVVGE.....QD.....DLVTllalepndeivvnt.......................adpgnieledvdgnV...KK.....C...R.....VLWADH..P..P..GTSGSLILNPRGELVG.L..YGFG----....-----------fflstdrfgnyg.....................
R6X0L4_9PORP/402-439                 ........................................................................................................................................................................................avt----------------..----.......-------.------------------...-------.----........-.------.--..---..-.-.------.....--.....----...................................................-...--.....-...-.....------..E..G..GSSGSPLFNQNKQIVG.T..LSGGSSSC....-----------ekpngant.........................
#=GC SS_cons                         ..........................................................................................................................................................................................X--XXSEEEEEEEEETT..CEEE.......EEEEEEE.TTEEEEEHHHHTT--EEE...TTCEE-E.EEEE........T.TTTEEE.ES..SS-..-.-.---B-T....TS-.....EEEEE--TTS--EEE.............................EE--EEEEETTE...-E.....E...E.....EE----..-..T..TGTT-EEE-TTS-EEE.E..CCEEEEBT....TS-EEEEEE---................................
#=GC seq_cons                        ........................................................................................................................................................................................................................................................................................................................................................................s....t.....h...h.....lpphsh..p..s..GoSGS.llNpcpplVG.l..Yhuss..p................................................
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