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Database: Pfam
Entry: Peptidase_S7
LinkDB: Peptidase_S7
Original site: Peptidase_S7 
#=GF ID   Peptidase_S7
#=GF AC   PF00949.19
#=GF DE   Peptidase S7, Flavivirus NS3 serine protease 
#=GF PI   Flavi_helicase; 
#=GF AU   Finn RD
#=GF SE   Pfam-B_199 (release 3.0)
#=GF GA   20.00 20.00;
#=GF TC   20.00 20.00;
#=GF NC   19.90 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7642575
#=GF RT   Association between NS3 and NS5 proteins of dengue virus type 2
#=GF RT   in the putative RNA replicase is linked to differential
#=GF RT   phosphorylation of NS5. 
#=GF RA   Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE,
#=GF RA   Padmanabhan R; 
#=GF RL   J Biol Chem 1995;270:19100-19106.
#=GF RN   [2]
#=GF RM   2174669
#=GF RT   Flavivirus genome organization, expression, and replication. 
#=GF RA   Chambers TJ, Hahn CS, Galler R, Rice CM; 
#=GF RL   Annu Rev Microbiol 1990;44:649-688.
#=GF RN   [3]
#=GF RM   8269709
#=GF RT   Evolution and taxonomy of positive-strand RNA viruses:
#=GF RT   implications of comparative analysis of amino acid sequences. 
#=GF RA   Koonin EV, Dolja VV; 
#=GF RL   Crit Rev Biochem Mol Biol 1993;28:375-430.
#=GF RN   [4]
#=GF RM   10026173
#=GF RT   Dengue virus NS3 serine protease. Crystal structure and insights
#=GF RT   into interaction of the active site with substrates by molecular
#=GF RT   modeling and structural analysis of mutational effects. 
#=GF RA   Murthy HM, Clum S, Padmanabhan R; 
#=GF RL   J Biol Chem 1999;274:5573-5580.
#=GF DR   INTERPRO; IPR001850;
#=GF DR   MEROPS; S7;
#=GF DR   MEROPS; S7;
#=GF DR   SCOP; 1bef; fa;
#=GF CC   The viral genome is a positive strand RNA that encodes a single 
#=GF CC   polyprotein precursor. Processing of the polyprotein precursor
#=GF CC   into mature proteins is carried out by the host signal peptidase
#=GF CC   and by NS3 serine  protease, which requires NS2B (Pfam:PF01002)
#=GF CC   as a cofactor [4]. 
#=GF SQ   14
#=GS C5J5N2_MYCCR/18-75    AC C5J5N2.1
#=GS Y591_MYCPN/171-291    AC Q50336.1
#=GS A1TVN4_ACIAC/31-106   AC A1TVN4.1
#=GS POLG_YEFV1/1502-1655  AC P03314.1
#=GS Y589_MYCPN/14-134     AC Q50338.1
#=GS Y586_MYCPN/154-286    AC P75194.1
#=GS Y584_MYCPN/1-69       AC P75196.1
#=GS Y577_MYCPN/197-333    AC P75203.1
#=GS POLG_DEN1W/1492-1643  AC P17763.2
#=GS POLG_DEN1W/1492-1643  DR PDB; 3LKW A; 71-218;
#=GS POLG_DEN1W/1492-1643  DR PDB; 3L6P A; 71-218;
#=GS Y580_MYCPN/2-70       AC P75200.1
#=GS Y298_MYCGA/335-468    AC P33276.3
#=GS C8W2Y8_DESAS/110-164  AC C8W2Y8.1
#=GS R6X0L4_9PORP/402-439  AC R6X0L4.1
#=GS Q4AA40_MYCHJ/48-227   AC Q4AA40.1
C5J5N2_MYCCR/18-75               ....................................................................................................................................................................................lflytkd----------------..----.......-------------------------...-----------........-.------.--..---..-.-.------.....KK.....INSI........................N...DK.....L...Y.....VENIDF..N..D..GSSGSPLFY-KNKIVG.V.YKGKEVVQ....-----------gkltsffn.........................
Y591_MYCPN/171-291               ...........................................................................................................................................................................................WECKQGAERFSYGYFY..SNMA.......RLTKNLRQG------DPNAGSKTHI...EYSNELLDKDS........M.DQGIVR.FS..TFL..G.A.NINYHD.....YD.....YRQQ........................G...YG.....L...T.....LTDTNL..P..G..GSSGSLVFNQDKKISS.I.YSAATESD....----SVGYAQL.................................
A1TVN4_ACIAC/31-106              ................................................................................................................................................................pntavchsggtsgwrcgvqkstnsqqs----------------..----.......-------------------------...-----------........-.------.--..---..-.-.------.....--.....--IN........................G...RT.....F...T.....LSEANFcgA..P..GDSGGPVVNAENNALG.I.YTAALGKD....-----------ltgtcga..........................
POLG_YEFV1/1502-1655             ..........................................................................................................................................................................................e-HLEDGIYGIFQSTFL..GASQ.......RGVGVAQGGVFHTMWHVTRGAFLVR...NGKKLIPSWAS........V.KEDLVA.YG..GSW..K.L.EGRWDG....eEE.....VQLIaavpgknvvnv..qtkpslfkvrnG...GE.....I...G.....AVALDY..P..S..GTSGSPIVNRNGEVIG.L.YGNGILVG....DNSFVSAISQT.................................
#=GR POLG_YEFV1/1502-1655  AS    .......................................................................................................................................................................................................................................*...................................*....................................................................................................*........................................................................
Y589_MYCPN/14-134                ...........................................................................................................................................................................................FEWTKTEQRFNHDDFY..GSMP.......TLTKNLRQG------QPVAGSKVHT...DYSNGFLNEYS........L.NQGIVD.FG..TFK..S.A.ITDYHG.....YE.....YKNH........................G...YG.....L...A.....LTDTDL..L..G..GSSGSLVFNQDKKISS.I.YSAATESD....----SVGYAQL.................................
Y586_MYCPN/154-286               ...........................................................................................................................................................................................YLLGYPFLRNKAASLF.lNQTEqrkehmdKTTQILHEKPFVVLTDPAKPTLIRN..kGANFTGNTWTS........-.NYDLSK.KS..GLY..H.-.--KFLG.....KK.....YQIY........................G...KS.....I...V.....ISDLNL..S..S..GSSGSLLLNDRKQIVG.I.YFGVDGPK....---DELGFSQL.................................
Y584_MYCPN/1-69                  ........................................................................................................................................................................................mny----------------..----.......-------------------------...-----------........-.-----D.LS..QKF..K.V.YLEFSG.....KK.....YRIY........................G...QS.....I...G.....ISHLDL..G..G..GSSGSLLLNDKKQIAG.I.YFGVDGAN....---NELGLAQL.................................
Y577_MYCPN/197-333               ..........................................................................................................................................................................................v-ESNIAALNLNQTEVK.pTRPE.......-DVAQVTFKEPWSVDHHREIPTLTTnqlTTIKTKHFSGS........K.LSWPFD.HT..KSF..K.I.KNKWLG.....QN.....YQMY........................G...HG.....L...G.....IDQVNL..R..K..GTSSSLVINQKRQIVG.I.YFATVITNp.kkAVRNDVGLVQM.................................
POLG_DEN1W/1492-1643             ..........................................................................................................................................................................................v--LDDGIYRILQRGLL..GRSQ.......VGVGVFQEGVFHTMWHVTRGAVLMY...QGKRLEPSWAS........V.KKDLIS.YG..GGW..R.F.QGSWNA....gEE.....VQVIavepgknpknv..qtapgtfktpeG...-E.....V...G.....AIALDF..K..P..GTSGSPIVNREGKIVG.L.YGNGVVTT....SGTYVSAIAQ-a................................
#=GR POLG_DEN1W/1492-1643  SS    ..........................................................................................................................................................................................X--XXXEEEEEEEEETT..CEEE.......EEEEEEETTEEEEEHHHHTT--EEE...TTEEE-EEEEE........T.TTTEEE.ES..SS-..-.-.-----T....T--.....EEEEE--TTS--EEE..EE--EEEEETTE...-E.....E...E.....EE----..-..T..T-TT-EEE-TTS-EEE.E.CEEEEE-T....TS-EEEEEE---................................
#=GR POLG_DEN1W/1492-1643  AS    .......................................................................................................................................................................................................................................*...................................*....................................................................................................*........................................................................
Y580_MYCPN/2-70                  ........................................................................................................................................................................................taq----------------..----.......-------------------------...-----------........-.------.--..-YY..Q.L.DEKFNQ.....QT.....YEQY........................G...KG.....L...A.....LNDLYI..R..R..GASGSLVFNQDQQISG.I.FFAVASHS....-----------dpkpgektlvql.....................
Y298_MYCGA/335-468               ...........................................................................................................................................................................................WPTTPQYTKFSVPSLS..-RRQ.......IPITSDSRGSPGWTINALNPTELDG...QKIASSTSLSSt.....ggI.RAGIYN.AD..IAR..N.F.QLVYRN.....VK.....YKQY........................G...YG.....Y...I.....IQNSNL..S..A..GSSGSLALTSNNQALG.I.YFGTVSVD...aKKEATFGLVA-s................................
C8W2Y8_DESAS/110-164             ........................................................................................................................................................................vgvtlqvqiseteigwfse----------------..----.......-------------------------...-----------........-.------.--..---..-.-.------.....--.....----........................-...--.....Q...V.....VCDMNS..Q..P..GDSGSLIVNNNKKAVG.L.LFAG----....-----------sdkft............................
R6X0L4_9PORP/402-439             ........................................................................................................................................................................................avt----------------..----.......-------------------------...-----------........-.------.--..---..-.-.------.....--.....----........................-...--.....-...-.....------..E..G..GSSGSPLFNQNKQIVG.T.LSGGSSSC....-----------ekpngant.........................
Q4AA40_MYCHJ/48-227              ................................................eneknltrftatlvkktnnnltfvstfhslnsiknniqqqvfdiflqqfsvknletklkskirveyenkekdiivfsldikeplllrisdsidfqvledftntknslfslgfltilnedfkpktlktlfyvndkvveld----------------..----.......-------------------------...-----------........-.------.--..---..-.-.------.....--.....----........................K...EN.....V...F.....VQDINY..R..Q..GSSGSPLFY-KNKIVG.L.YRGKK---....-----------lkngklt..........................
#=GC SS_cons                     ..........................................................................................................................................................................................X--XXXEEEEEEEEETT..CEEE.......EEEEEEETTEEEEEHHHHTT--EEE...TTEEE-EEEEE........T.TTTEEE.ES..SS-..-.-.-----T....T--.....EEEEE--TTS--EEE..EE--EEEEETTE...-E.....E...E.....EE----..-..T..T-TT-EEE-TTS-EEE.E.CEEEEE-T....TS-EEEEEE---................................
#=GC seq_cons                    ......................................................................................................................................................................................................................................................................................h..t......a.t......p.....hp.h........................G....s.....l...s.....lsshsh..p..s..GoSGS.lhNpcppIlG.l.Yhuss.ss................................................
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