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Database: Pfam
Entry: Phage_integ_N
LinkDB: Phage_integ_N
Original site: Phage_integ_N 
#=GF ID   Phage_integ_N
#=GF AC   PF09003.8
#=GF DE   Bacteriophage lambda integrase, N-terminal domain 
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1kjk
#=GF GA   21.80 21.80;
#=GF TC   22.30 21.90;
#=GF NC   21.50 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11904406
#=GF RT   Arm-site binding by lambda -integrase: solution structure and
#=GF RT   functional characterization of its amino-terminal domain. 
#=GF RA   Wojciak JM, Sarkar D, Landy A, Clubb RT; 
#=GF RL   Proc Natl Acad Sci U S A. 2002;99:3434-3439.
#=GF DR   INTERPRO; IPR015094;
#=GF CC   The amino terminal domain of bacteriophage lambda integrase
#=GF CC   folds into a three-stranded, antiparallel beta-sheet that packs
#=GF CC   against a C-terminal alpha-helix, adopting a fold that is
#=GF CC   structurally related to the three-stranded beta-sheet family of
#=GF CC   DNA-binding domains (which includes the GCC-box DNA-binding
#=GF CC   domain and the N-terminal domain of Tn916 integrase). This
#=GF CC   domain is responsible for high-affinity binding to each of the
#=GF CC   five DNA arm-type sites and is also a context-sensitive
#=GF CC   modulator of DNA cleavage [1].
#=GF SQ   57
#=GS Q2NUH1_SODGM/1-69      AC Q2NUH1.1
#=GS Q32DW2_SHIDS/11-63     AC Q32DW2.1
#=GS W8V7R9_YEREN/1-71      AC W8V7R9.1
#=GS M9WYK5_MANHA/1-72      AC M9WYK5.1
#=GS Q2W5Y0_MAGSA/1-70      AC Q2W5Y0.1
#=GS C4K6X1_HAMD5/6-74      AC C4K6X1.1
#=GS Q2NU13_SODGM/1-69      AC Q2NU13.1
#=GS C0B0W1_9ENTR/1-73      AC C0B0W1.1
#=GS Q31HX1_THICR/1-73      AC Q31HX1.1
#=GS D0L1C6_HALNC/1-69      AC D0L1C6.1
#=GS E6WK98_PANSA/1-72      AC E6WK98.1
#=GS Q88MN9_PSEPK/1-73      AC Q88MN9.1
#=GS B2JXJ9_BURP8/79-135    AC B2JXJ9.1
#=GS A0A0M2K9C4_9ENTR/1-65  AC A0A0M2K9C4.1
#=GS I3D892_HAEPH/55-126    AC I3D892.1
#=GS W8UG24_YEREN/1-59      AC W8UG24.1
#=GS C4K6K4_HAMD5/5-70      AC C4K6K4.1
#=GS A0A0G4K1F2_9ENTR/1-71  AC A0A0G4K1F2.1
#=GS W0LJI0_9ENTR/1-71      AC W0LJI0.1
#=GS M9X5M2_MANHA/1-74      AC M9X5M2.1
#=GS VINT_LAMBD/1-69        AC P03700.1
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1G B; 10-69;
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1G C; 8-69;
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1B A; 8-69;
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1G A; 8-69;
#=GS VINT_LAMBD/1-69        DR PDB; 2WCC 3; 1-64;
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1B B; 7-69;
#=GS VINT_LAMBD/1-69        DR PDB; 1Z1G D; 10-69;
#=GS VINT_LAMBD/1-69        DR PDB; 1KJK A; 11-59;
#=GS G2GWG9_9ENTR/6-72      AC G2GWG9.1
#=GS B4EVG6_PROMH/1-73      AC B4EVG6.1
#=GS K8WAK1_PRORE/1-73      AC K8WAK1.1
#=GS A0A068R4G2_9ENTR/1-73  AC A0A068R4G2.1
#=GS C5B8B5_EDWI9/1-73      AC C5B8B5.1
#=GS E0WTS0_9ENTR/1-67      AC E0WTS0.1
#=GS B4ETH4_PROMH/1-73      AC B4ETH4.1
#=GS G2GZA0_9ENTR/1-67      AC G2GZA0.1
#=GS Q2NSA1_SODGM/1-72      AC Q2NSA1.1
#=GS C5BBQ8_EDWI9/5-64      AC C5BBQ8.1
#=GS W8UHX5_YEREN/1-72      AC W8UHX5.1
#=GS A0A0M2KE86_9ENTR/1-73  AC A0A0M2KE86.1
#=GS E4PQQ1_MARAH/1-70      AC E4PQQ1.1
#=GS C5CJJ9_VARPS/1-71      AC C5CJJ9.1
#=GS A4WB58_ENT38/1-72      AC A4WB58.1
#=GS M1FBS6_9ALTE/1-40      AC M1FBS6.1
#=GS A0A0M2KIZ5_9ENTR/1-69  AC A0A0M2KIZ5.1
#=GS G8MES6_9BURK/1-69      AC G8MES6.1
#=GS Q2W5Z6_MAGSA/1-68      AC Q2W5Z6.1
#=GS A0A0N0GNR2_9NEIS/1-73  AC A0A0N0GNR2.1
#=GS A0A0L0GWW8_9ENTR/1-72  AC A0A0L0GWW8.1
#=GS A0A068Z0E5_9ENTR/5-73  AC A0A068Z0E5.1
#=GS G7LMX6_9ENTR/1-71      AC G7LMX6.1
#=GS A3MZK6_ACTP2/1-74      AC A3MZK6.1
#=GS A0A0K1QQZ7_PSEFL/1-62  AC A0A0K1QQZ7.1
#=GS A7MHR0_CROS8/1-67      AC A7MHR0.1
#=GS V2UTD4_9GAMM/1-71      AC V2UTD4.1
#=GS E6WS25_PSEUU/1-63      AC E6WS25.1
#=GS G2GZ16_9ENTR/1-67      AC G2GZ16.1
#=GS B4ESJ2_PROMH/1-66      AC B4ESJ2.1
#=GS E1SK89_PANVC/1-73      AC E1SK89.1
#=GS INTE_ECOLI/1-73        AC P75969.1
#=GS J7TA84_MORMO/1-73      AC J7TA84.1
#=GS V5CS53_ENTCL/1-70      AC V5CS53.1
#=GS A0A060BG05_9GAMM/1-61  AC A0A060BG05.1
#=GS A0A089WMK5_9PSED/1-63  AC A0A089WMK5.1
Q2NUH1_SODGM/1-69                 .......MARRRSH.KNRDLPPNLQPI--.---.N..GG...Y..FCYR.DPRTGKEYGLGR.NRREAITQAIAANMA.IYGSSKQSPLVDRI-s............
Q32DW2_SHIDS/11-63                nsvchfn-------.--------------.---.-..--...-..YCYR.DPRTGKEFGLGR.DRRIAITEAIQANIE.LLSDSGRESLIDRIK.............
W8V7R9_YEREN/1-71                 .......MAKRPGK.YDANLPKNLTFR--.-RV.-..QL...T..FYWR.NPLTGKELSLGKiARRDAISQAIEANNF.IEQNYTPVALLEKL-k............
M9WYK5_MANHA/1-72                 ......m--ARPRKyENNGLPQNLLCRRR.KRA.N..GSiveY..YFYV.-LADGKERSLGT.NKHEAILEAAKLNFE.---------------nsrkspivlfi..
Q2W5Y0_MAGSA/1-70                 .......MPGKRRNmSRRDWPANLRCR--.---.R..DG...Y..YSWV.NPTDGREYGLGR.DKRAAFAQAVEANLQ.IMALCDKPRLVDRL-n............
C4K6X1_HAMD5/6-74                 ....gpn-----RK.NSRDLSPHLHVR--.---.H..QG...Y..YCYR.DPRTGKEYGLGK.EKRMAINEAISANRQ.IFDA-----------pvslndrinevka
Q2NU13_SODGM/1-69                 .......MARRRSH.KNRDLPPNLQPR--.---.N..GG...Y..ICYR.DPRTGKEYGLGC.NRREAITQAIAANMA.IYGSSKQSPLVDSI-s............
C0B0W1_9ENTR/1-73                 .......MAARPRT.HKIIIP-NLYRKLD.KRN.G..KI...Y..WQYK.HPITDKFHSLGT.DEQEARETAIQANTI.IAEQHTRQLLSINE-r............
Q31HX1_THICR/1-73                 .......MSPKARE.ISLGLPPNLYAKKD.KRN.G..KV...Y..YQYK.SPLDGKFYSFGT.DKNQAVNDAVALNHN.IYDAIQKSRV-----eklk.........
D0L1C6_HALNC/1-69                 .......MARPRSR.KKNDLPANLYE---.--P.R..AG...Y..FVYR.NPENGKTYTLGRiSRGEARDQAIEANRT.F-EQRAEQRLINRL-h............
E6WK98_PANSA/1-72                 .......MAARPRR.HNVTIP-NLYCKLD.KRT.S..KV...Y..WQYR.HPVTNQFIGFGT.DEDAAKEAAIEANRI.ISQQQTKQIT-----ilvd.........
Q88MN9_PSEPK/1-73                 .......MAPRPRNpGSKDLPPNLYRKTD.KRN.G..VT...Y..YTYR.DPVSDRMFGLGS.DKAKAIAEAVSANMA.L--QVAPPTLSARI-a............
B2JXJ9_BURP8/79-135               .agnlhe-------.--------------.--P.R..PG...Y..YVWR.NPITKKTMSIGY.VPIEQVFEVLEANAK.AKEIVPTKRLVERM-k............
A0A0M2K9C4_9ENTR/1-65             .......MASRPRKrENRHLPDYLYYDVS.HGQ.-..--...-..--YRiTLISGKRKHLGA.DRARAIAIAREYNNQ.MR-------------pesavsls.....
I3D892_HAEPH/55-126               ....lhh-----KR.QNQGLPPNLLCRRR.KRA.S..GQiveY..FYYI.-LANGKEKSLGS.DKYHAVLEAAKLNMA.SH-------------qvseivlfidv..
W8UG24_YEREN/1-59                 ......m-------.---------YAKLD.KRT.G..RV...Y..WQYK.HPISGKFHGLGT.NEDEAKQVACEANDI.IAEQRTRQILSVNQ-k............
C4K6K4_HAMD5/5-70                 ...qgpn-----RK.NGRDLSPHLHVR--.---.H..QG...Y..YCYR.DPRTGKEYGLGK.EKRMAINEAISANRQ.ICD------------apvslndrin...
A0A0G4K1F2_9ENTR/1-71             .......MAKRMTR.YDANLPRNLTYRKR.RKS.-..--...-..FYWR.NPLTGEEFNLGAiARRDAISQAIEANCF.IEKNYSPTTLLERL-q............
W0LJI0_9ENTR/1-71                 .......MAKRPTR.YDANLPKNLTYRRK.YRS.-..--...-..FYWR.HPITRKELPLGQiARRDAVGQAIEANNY.LEQNYLPSTLIERIK.............
M9X5M2_MANHA/1-74                 ......m--GRPRKqQNRYLPENLRPKTV.TRKsGktVI...Y..WLYR.T-HGKTEISLGT.NRNEAFIKAAQLNIE.RESQTARI-------tfglv........
VINT_LAMBD/1-69                   .......MGRRRSH.ERRDLPPNLYIR--.---.N..NG...Y..YCYR.DPRTGKEFGLGR.DRRIAITEAIQANIE.LFSGHKHKPLTARIN.............
#=GR VINT_LAMBD/1-69        SS    .......XXXSXXS.SCGGS-TTEEEE--.---.T..TS...E..EEEE.-TTTS-EEEEES.-HHHHHHHHHHHHHH.HTSSSXSSSCCHHHH.............
G2GWG9_9ENTR/6-72                 ......h--ARKRKpANRDLPPNLYVR--.---.N..NG...Y..YCYR.DPRTGKEYGVGS.VKRMAINEAVAMNMQ.IFDQRH--SL-----vdrin........
B4EVG6_PROMH/1-73                 .......MAARPRT.HKITIP-NLYRKLD.KRN.G..KI...Y..WQYK.HPITGKFHSLGT.DEQEARETAIQANTI.IAEQHTRQLLSINE-r............
K8WAK1_PRORE/1-73                 .......MAARPRK.NNVNIP-NLYPLFS.RKA.N..KV...Y..WRYR.HPITGKFHALGD.NEAEAREIAIEANNR.LAEQRSRQVMAISD-r............
A0A068R4G2_9ENTR/1-73             .......MAARPRK.NNVNIP-NLYPLFS.RKA.N..KV...Y..WRYR.HPITGKYHSLGD.NEQEAKEIAIEANSR.LAEQRSRQVMAISD-r............
C5B8B5_EDWI9/1-73                 .......MAARPRT.HKITIP-NLYSKLD.KRT.G..RV...Y..WQYK.HPVTGNFHSLGT.NTEEAKQVASEANDI.IAEQRTRQILSVNE-k............
E0WTS0_9ENTR/1-67                 .......MARKRKP.DNRDLPPNLYVR--.---.N..NG...Y..YCYR.DPRTGKEYGVGS.VKRMAINEAVAMNMQ.IFDQRH--SL-----vdrin........
B4ETH4_PROMH/1-73                 .......MSGRPRK.KNIDIP-NLYSIYH.PRM.K..KI...Y..WRYR.HPISGKFHSLGD.DEAQAKQIALEANNR.IAEQRTRQILII---gdr..........
G2GZA0_9ENTR/1-67                 .......MARKRKP.ANRDLPPNLYVR--.---.N..NG...Y..YCYR.DPRTGKEYGVGS.VKRMAINEAVAMNMQ.IFEQRH--SL-----vdrin........
Q2NSA1_SODGM/1-72                 ......m--GRPRK.YNVTIP-GLSCFID.KRT.K..RV...Y..WRYK.HPVTGKFHGLGT.DEDSAREIAVEANTR.LAEHKMGQLFTARD-n............
C5BBQ8_EDWI9/5-64                 nddsatp-------.---KLPDNLYCK--.---.-..GG...F..FIWR.NPLSGQEMPLGYiKKNEAVRQAQEANQY.IDTQR----------pmve.........
W8UHX5_YEREN/1-72                 ......m--GRPRK.YNVDVP-GLSCYTD.ART.K..KV...Y..WRYK.HPVSGKFHGLGD.NEVEAKSIAVEANTR.FAQQQMGQLITARDK.............
A0A0M2KE86_9ENTR/1-73             .......MAARPRT.HKITIP-NLYSKLD.KRT.G..RV...Y..WQYK.HPVTGKFHSLGT.DAEEARQVASEANDI.IAEQRTRQILSVNE-k............
E4PQQ1_MARAH/1-70                 .......MAPRKRLkKNKDLVENLY--GS.TKN.G..VT...Y..YQYK.HPVTGQYHSMGT.NKQEANAAARQLNSI.LIP------------ernlvaqvm....
C5CJJ9_VARPS/1-71                 .......MAARPRArPRREWPTGLH----.-ES.R..PG...Y..FVWF.NPVAKKYVAIGRvTLADARLQAIEANLW.ASEQLGKARLIDRLQ.............
A4WB58_ENT38/1-72                 .......MSPRPRK.NNVSIS-GLYARFD.RRT.A..KT...Y..YQYK.NPLTGKFHGLGT.DRDKAEKIASTANQR.IAAAEAEHYL-----rqid.........
M1FBS6_9ALTE/1-40                 ......m-------.--------------.---.-..-T...Y..FSYR.HPQTAKRHGMGS.NRQKANAAARVLNSR.LM-------------avgd.........
A0A0M2KIZ5_9ENTR/1-69             .......MAARRRShKTRDLPPNLYVR--.---.N..DG...Y..YSYR.DPRTGKEYGLGR.DKRYAVTQAIEANMS.MVDSPTASL------ierms........
G8MES6_9BURK/1-69                 .......MNARRRQaARRSWPENLY----.-QN.A..DG...Y..FWFR.NPITKKTAGCGT.DLQKAIKMVKAANLG.LEKLKAER-------dllaat.......
Q2W5Z6_MAGSA/1-68                 .......MARRRSI.KRRGWPENLYE---.---.T..RG...Y..FIWR.NPIDGKKHGLGR.DKASASLQAIEANLH.IAGMLTKSRLIDR--vl...........
A0A0N0GNR2_9NEIS/1-73             .......MAGRRHR.SRRNWPDHLLAR--.EKA.K..GL...Y..YYWR.DPRTGKEYGLGY.DFADAASQVREANAVaLATRSPKASLVDRL-s............
A0A0L0GWW8_9ENTR/1-72             .......MSPRPRK.NSISIP-GLYARFD.RRT.D..KT...Y..YQYK.NPVTGKFHGLGT.DKTKAEKIAITANQR.LAAAEAD--------yflkqid......
A0A068Z0E5_9ENTR/5-73             .......MARKRTH.SRRDLPPNLYVR--.---.N..NG...Y..YCYR.DPRNGKEFGLGT.NKKEAVNQAIEANIT.LVESYSQSRLIDRL-i............
G7LMX6_9ENTR/1-71                 .......MAKRPAR.YDANLPKNLTYRRR.EKS.-..--...-..FYWR.NPLTDQEFSLGRiSRKDAIGQAIEANHY.IEQNYAPIVLLEKL-q............
A3MZK6_ACTP2/1-74                 ......m--ARPRKrENNGLPQNLLCRRR.KRA.S..GQiveY..FYYV.M-ADSKEKSLGT.NKYEAVLEAAKLNFE.FQK------------kgevvlfidv...
A0A0K1QQZ7_PSEFL/1-62             .......MVPRPRNkANKNLPQNLYFDAR.RS-.-..--...T..YRYR.RPTDGKWFPFGA.DRIKAIDAAKQLNLE.F--------------mrgad........
A7MHR0_CROS8/1-67                 .......MAGRPRKrENRHFPDYLY--FD.KET.G..Q-...-..YRFQ.-LITGKRKNIGT.DRAVAIAIAREYNLR.MRPESMPS-------iesl.........
V2UTD4_9GAMM/1-71                 .......MTPRGRGvGYQDLPPHVEI-DK.KAN.G..TV...Y..YRYL.LPN-GQRKSLGK.DKTEAIQAAQALNAV.LER------------npdivskils...
E6WS25_PSEUU/1-63                 .......MVPRQRSkARAGWPANLYT---.--S.G..RG...G..FKYR.HPVTKAETWMGT.DKAKAFAAARKLNAL.L--------------tpsddlv......
G2GZ16_9ENTR/1-67                 .......MARKRKP.ANRDLPPNLYVR--.---.N..NG...Y..YCYR.DPRTGKEYGVGS.VKRMAINEAVAMNMQ.IFDQRH--SL-----vdrin........
B4ESJ2_PROMH/1-66                 .......MGRSRSA.KNKGLPPNLYLR--.---.-..KG...I..YYYR.DVRTKKEFSVGS.NKSLAITEAIQANLA.IYK--PKESLVDRI-n............
E1SK89_PANVC/1-73                 .......MAARPRT.HNITIP-NLYSKLD.KRT.G..RV...Y..WQYK.HPITGKFHSLGT.NADEAKQVANEANAI.IAEQRTRQILSVNE-k............
INTE_ECOLI/1-73                   .......MAARPRK.NNVSVP-NLYPLYS.RKV.N..KV...Y..WRYK.HPVTGKFHALGT.NEAEAIAIATEANTR.LAEQRTRQILAISD-r............
J7TA84_MORMO/1-73                 .......MAARPRK.NNINIP-NLYPFFS.RKT.S..KV...Y..WRYR.HPVTGKFHYLGD.NEEEAKIIAVEANLR.LAEQRSRQVMAISD-r............
V5CS53_ENTCL/1-70                 ......m--QRPAR.YDANLPRNLTFR--.KR-.-..DK...L..YSWR.NPITGQVIYLGRiDRREAIAQAIEANSY.LDQNYIPSSLLQRIK.............
A0A060BG05_9GAMM/1-61             .......MAPRPRKrKNKGLEPNLY----.--E.S..DG...Y..YIYR.RPDTGKRHGMGR.DRAKAQDAARILNVR.LMK------------gadl.........
A0A089WMK5_9PSED/1-63             ......m---RPRStENRDLPPGMYRRKRvRKS.G..KV...WvgYYYR.DQV-GKEIPLGT.DLPKAKLK-------.---------------waeleaksap...
#=GC SS_cons                      .......XXXSXXS.SCGGS-TTEEEE--.---.T..TS...E..EEEE.-TTTS-EEEEES.-HHHHHHHHHHHHHH.HTSSSXSSSCCHHHH.............
#=GC seq_cons                     .......MutR.Rp.pstslP.NLYh+....t..s..ps...Y..apYR.cPhTGKpauLGs.s+pcAhptAlpANht.lhpp.t...h.....t............
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