GenomeNet

Database: Pfam
Entry: Phe_ZIP
LinkDB: Phe_ZIP
Original site: Phe_ZIP 
#=GF ID   Phe_ZIP
#=GF AC   PF08916.6
#=GF DE   Phenylalanine zipper
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1q2h
#=GF GA   25.00 25.00;
#=GF TC   30.00 35.20;
#=GF NC   23.70 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15378031
#=GF RT   A phenylalanine zipper mediates APS dimerization. 
#=GF RA   Dhe-Paganon S, Werner ED, Nishi M, Hansen L, Chi YI, Shoelson
#=GF RA   SE; 
#=GF RL   Nat Struct Mol Biol. 2004;11:968-974.
#=GF DR   INTERPRO; IPR015012;
#=GF CC   The phenylalanine zipper consists of aromatic side chains from
#=GF CC   ten phenylalanine residues that are stacked within a hydrophobic
#=GF CC   core. This zipper mediates dimerisation of various proteins,
#=GF CC   such as APS, SH2-B and Lnk [1].
#=GF SQ   161
#=GS G3SZY7_LOXAF/34-91    AC G3SZY7.1
#=GS H9HV06_ATTCE/179-239  AC H9HV06.1
#=GS B7PEL7_IXOSC/15-73    AC B7PEL7.1
#=GS H0VC40_CAVPO/24-82    AC H0VC40.1
#=GS B4NJB3_DROWI/70-130   AC B4NJB3.1
#=GS F6T5J1_CALJA/21-78    AC F6T5J1.1
#=GS H2V1E5_TAKRU/16-73    AC H2V1E5.1
#=GS H2QV58_PANTR/63-121   AC H2QV58.1
#=GS SH2B3_HUMAN/24-81     AC Q9UQQ2.2
#=GS H2RA95_PANTR/24-75    AC H2RA95.1
#=GS G1RA88_NOMLE/62-120   AC G1RA88.1
#=GS F1MRH8_BOVIN/24-82    AC F1MRH8.1
#=GS F7HMI6_CALJA/19-77    AC F7HMI6.1
#=GS G1RK13_NOMLE/24-82    AC G1RK13.1
#=GS G1RK08_NOMLE/24-82    AC G1RK08.1
#=GS SH2B1_RAT/24-82       AC Q62985.1
#=GS E5SE34_TRISP/30-88    AC E5SE34.1
#=GS D4ABY6_RAT/22-77      AC D4ABY6.1
#=GS F6P9Y8_DANRE/20-77    AC F6P9Y8.1
#=GS E3Q1M8_PIG/24-82      AC E3Q1M8.1
#=GS G3W753_SARHA/26-84    AC G3W753.1
#=GS D3Z0T9_MOUSE/22-77    AC D3Z0T9.1
#=GS G1TLV4_RABIT/14-74    AC G1TLV4.1
#=GS H9G672_ANOCA/24-81    AC H9G672.1
#=GS H9KF89_APIME/51-111   AC H9KF89.1
#=GS G1MAQ2_AILME/24-82    AC G1MAQ2.1
#=GS B3KNV5_HUMAN/24-82    AC B3KNV5.1
#=GS F7DWZ1_MACMU/1-56     AC F7DWZ1.1
#=GS G5BRD6_HETGA/18-76    AC G5BRD6.1
#=GS E2QSF1_CANFA/37-94    AC E2QSF1.1
#=GS F6WSM1_HORSE/5-63     AC F6WSM1.1
#=GS G1P924_MYOLU/24-82    AC G1P924.1
#=GS H2T7P0_TAKRU/24-66    AC H2T7P0.1
#=GS H0XXM5_OTOGA/19-77    AC H0XXM5.1
#=GS C9JK89_HUMAN/21-79    AC C9JK89.1
#=GS Q4SPM1_TETNG/3-61     AC Q4SPM1.1
#=GS H3CQK3_TETNG/19-77    AC H3CQK3.1
#=GS G3QL56_GORGO/24-81    AC G3QL56.1
#=GS F7FFS9_ORNAN/16-73    AC F7FFS9.1
#=GS F1MJV1_BOVIN/24-82    AC F1MJV1.2
#=GS F6UTE1_ORNAN/20-78    AC F6UTE1.1
#=GS F7HNX1_CALJA/24-82    AC F7HNX1.1
#=GS H3BDE6_LATCH/2-60     AC H3BDE6.1
#=GS G1QI22_NOMLE/23-80    AC G1QI22.1
#=GS Q296W8_DROPS/60-120   AC Q296W8.1
#=GS B4PT03_DROYA/69-129   AC B4PT03.1
#=GS SH2B1_HUMAN/24-82     AC Q9NRF2.3
#=GS B4ICF2_DROSE/67-127   AC B4ICF2.1
#=GS F6S3C2_MONDO/29-87    AC F6S3C2.1
#=GS E1ZY46_CAMFO/101-161  AC E1ZY46.1
#=GS G6D5M7_DANPL/10-70    AC G6D5M7.1
#=GS G3THH9_LOXAF/24-82    AC G3THH9.1
#=GS H3BTK4_HUMAN/24-57    AC H3BTK4.1
#=GS H2LPP1_ORYLA/19-77    AC H2LPP1.1
#=GS H3IC86_STRPU/10-78    AC H3IC86.1
#=GS G9KNK2_MUSPF/50-108   AC G9KNK2.1
#=GS G3QZH2_GORGO/21-66    AC G3QZH2.1
#=GS G1SIG7_RABIT/13-68    AC G1SIG7.1
#=GS A2RUZ0_DANRE/70-127   AC A2RUZ0.1
#=GS B0X2Z7_CULQU/66-126   AC B0X2Z7.1
#=GS H3AZC9_LATCH/15-72    AC H3AZC9.1
#=GS B4K575_DROMO/55-115   AC B4K575.1
#=GS E2B5K5_HARSA/60-120   AC E2B5K5.1
#=GS G1N121_MELGA/15-72    AC G1N121.2
#=GS D2A4V7_TRICA/12-72    AC D2A4V7.1
#=GS H2V1E3_TAKRU/23-80    AC H2V1E3.1
#=GS B4QVG0_DROSI/66-126   AC B4QVG0.1
#=GS H9FSN3_MACMU/24-82    AC H9FSN3.1
#=GS D6RCY9_MOUSE/22-77    AC D6RCY9.1
#=GS B3P6D9_DROER/66-126   AC B3P6D9.1
#=GS H2T7N9_TAKRU/19-77    AC H2T7N9.1
#=GS B4GEJ4_DROPE/60-120   AC B4GEJ4.1
#=GS G3W1L1_SARHA/15-72    AC G3W1L1.1
#=GS H3CLY4_TETNG/8-64     AC H3CLY4.1
#=GS H9FSN5_MACMU/24-82    AC H9FSN5.1
#=GS Q17DJ2_AEDAE/58-118   AC Q17DJ2.1
#=GS Q7K137_DROME/66-126   AC Q7K137.1
#=GS F7HUD9_CALJA/24-82    AC F7HUD9.1
#=GS SH2B2_MOUSE/16-74     AC Q9JID9.2
#=GS D2GVU7_AILME/31-83    AC D2GVU7.1
#=GS B3LYK3_DROAN/67-127   AC B3LYK3.1
#=GS F6VVV9_MONDO/15-73    AC F6VVV9.1
#=GS G7NQG6_MACMU/24-82    AC G7NQG6.1
#=GS G1M5A5_AILME/31-86    AC G1M5A5.1
#=GS H3BYX8_TETNG/23-80    AC H3BYX8.1
#=GS G5AXB0_HETGA/5-63     AC G5AXB0.1
#=GS G3SQP8_LOXAF/15-73    AC G3SQP8.1
#=GS F6V4P5_XENTR/15-73    AC F6V4P5.1
#=GS Q7QFS7_ANOGA/90-150   AC Q7QFS7.5
#=GS H0XH91_OTOGA/24-82    AC H0XH91.1
#=GS F4WHU7_ACREC/1-61     AC F4WHU7.1
#=GS B4LYY8_DROVI/94-154   AC B4LYY8.1
#=GS G9KNK3_MUSPF/1-46     AC G9KNK3.1
#=GS H0Y1V5_OTOGA/26-83    AC H0Y1V5.1
#=GS F7DWZ7_MACMU/1-56     AC F7DWZ7.1
#=GS F6PIB3_MONDO/1-57     AC F6PIB3.1
#=GS H2Q6W1_PANTR/24-81    AC H2Q6W1.1
#=GS H2NIN8_PONAB/24-81    AC H2NIN8.1
#=GS F7I7H3_CALJA/19-76    AC F7I7H3.1
#=GS G3U0X8_LOXAF/16-74    AC G3U0X8.1
#=GS F1RKF8_PIG/22-80      AC F1RKF8.1
#=GS F1PRX4_CANFA/79-137   AC F1PRX4.1
#=GS D2HX27_AILME/24-82    AC D2HX27.1
#=GS G3RLC3_GORGO/21-79    AC G3RLC3.1
#=GS E2QSF0_CANFA/19-77    AC E2QSF0.1
#=GS E0VIR8_PEDHC/14-72    AC E0VIR8.1
#=GS H9FSN4_MACMU/24-82    AC H9FSN4.1
#=GS H9GLW0_ANOCA/24-82    AC H9GLW0.1
#=GS Q4SUR2_TETNG/18-74    AC Q4SUR2.1
#=GS G1RA91_NOMLE/19-77    AC G1RA91.1
#=GS H3BX30_TETNG/23-80    AC H3BX30.1
#=GS D3Z3Y5_MOUSE/22-77    AC D3Z3Y5.1
#=GS H2PLT4_PONAB/19-77    AC H2PLT4.1
#=GS H2T7N8_TAKRU/19-77    AC H2T7N8.1
#=GS G3P6B2_GASAC/19-77    AC G3P6B2.1
#=GS F5GY53_HUMAN/64-122   AC F5GY53.1
#=GS G3W1L2_SARHA/15-72    AC G3W1L2.1
#=GS H2LES0_ORYLA/24-81    AC H2LES0.1
#=GS H3AF52_LATCH/15-73    AC H3AF52.1
#=GS F1RFI0_PIG/24-82      AC F1RFI0.1
#=GS F6RGT3_MACMU/21-79    AC F6RGT3.1
#=GS F7ISI1_CALJA/24-82    AC F7ISI1.1
#=GS G3S1G9_GORGO/16-73    AC G3S1G9.1
#=GS E9QI81_DANRE/70-109   AC E9QI81.1
#=GS H9JUP9_BOMMO/10-70    AC H9JUP9.1
#=GS F6PIB6_MONDO/1-57     AC F6PIB6.1
#=GS SH2B1_MOUSE/24-82     AC Q91ZM2.2
#=GS H0Z7W7_TAEGU/4-61     AC H0Z7W7.1
#=GS F7C8E3_HORSE/24-82    AC F7C8E3.1
#=GS G3NSJ6_GASAC/29-86    AC G3NSJ6.1
#=GS F1LM14_RAT/16-74      AC F1LM14.1
#=GS H2RN85_TAKRU/24-81    AC H2RN85.1
#=GS G3S3N8_GORGO/35-80    AC G3S3N8.1
#=GS H2V1E4_TAKRU/23-80    AC H2V1E4.1
#=GS E2RSS6_CANFA/24-82    AC E2RSS6.1
#=GS E3WMU5_ANODA/100-160  AC E3WMU5.1
#=GS F1NFS1_CHICK/19-77    AC F1NFS1.1
#=GS G1U818_RABIT/12-70    AC G1U818.1
#=GS G3I7M3_CRIGR/24-82    AC G3I7M3.1
#=GS E1BE90_BOVIN/28-85    AC E1BE90.1
#=GS H3BVF6_HUMAN/24-63    AC H3BVF6.1
#=GS F1RMZ2_PIG/26-83      AC F1RMZ2.1
#=GS G3WFN7_SARHA/25-83    AC G3WFN7.1
#=GS H0Z1Y1_TAEGU/4-62     AC H0Z1Y1.1
#=GS B4JYY2_DROGR/56-116   AC B4JYY2.1
#=GS F6V8B6_CALJA/19-77    AC F6V8B6.1
#=GS G1PET6_MYOLU/24-82    AC G1PET6.1
#=GS SH2B2_RAT/16-74       AC Q9Z200.1
#=GS H3BWZ9_TETNG/8-64     AC H3BWZ9.1
#=GS H0VAD8_CAVPO/16-74    AC H0VAD8.1
#=GS F7ISL7_CALJA/10-68    AC F7ISL7.1
#=GS F6W719_MACMU/24-81    AC F6W719.1
#=GS E1BXL2_CHICK/15-72    AC E1BXL2.1
#=GS SH2B2_HUMAN/21-79     AC O14492.2
#=GS SH2B2_HUMAN/21-79     DR PDB; 1Q2H B; 21-79;
#=GS SH2B2_HUMAN/21-79     DR PDB; 1Q2H C; 21-79;
#=GS SH2B2_HUMAN/21-79     DR PDB; 1Q2H A; 21-79;
#=GS F6PIA5_MONDO/1-57     AC F6PIA5.1
#=GS G1MWL7_MELGA/20-78    AC G1MWL7.2
#=GS A4QN29_XENTR/30-87    AC A4QN29.1
#=GS SH2B3_MOUSE/22-77     AC O09039.2
#=GS E7FFS4_DANRE/18-76    AC E7FFS4.1
#=GS G3RMX7_GORGO/27-85    AC G3RMX7.1
#=GS H3BDE5_LATCH/15-73    AC H3BDE5.1
G3SZY7_LOXAF/34-91               ....RGWSEFCELHAVATAREL.ARQYWLFA.......RDH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVRR.....
H9HV06_ATTCE/179-239             ....TGWIEFCERHARASASDF.AKAFCAYV.......SLN.lPES..ARaN.L.SHR...DFLRKFVES..FCEHFESEY--lr...
B7PEL7_IXOSC/15-73               ...p-HWPDFCEKHARVAAAEF.AQNYQHFV.......ADH..RDT..AK.A.V.DFL...EFGRRFADV..FLEHYEAEVKR.....
H0VC40_CAVPO/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
B4NJB3_DROWI/70-130              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.PHR...SFAQKFVES..FSEHYDTEFFR.....
F6T5J1_CALJA/21-78               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
H2V1E5_TAKRU/16-73               ....RGWREFCELHAIATARQL.AGHYRSFA.......RER..PQQ..-D.V.L.PPE...LFSKQFTDL..FQQHFCCEVD-k....
H2QV58_PANTR/63-121              ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
SH2B3_HUMAN/24-81                ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
H2RA95_PANTR/24-75               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRYVEL..FLQ--------p....
G1RA88_NOMLE/62-120              ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSHHFAAN..FLDVFGEEVRR.....
F1MRH8_BOVIN/24-82               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFSEEVRR.....
F7HMI6_CALJA/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFSEEVRR.....
G1RK13_NOMLE/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G1RK08_NOMLE/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
SH2B1_RAT/24-82                  ....PSWQEFCESHARAAALDL.ARRFRLYL.......ASH..PQY..AE.P.G.AEA...AFSGRFAEL..FLQHFEAEVAR.....
E5SE34_TRISP/30-88               ..lv--WTEFCESCAKFAAYDF.AQSWRNYL.......TLN..PQM..ID.R.V.SEQ...EAAAKFVQA..FGSYFENEAR-r....
D4ABY6_RAT/22-77                 ....RGWSDFCERHAAAAARDL.ARQYWLFA.......RAH..PQP..--.-.P.RAD...LVSLQFAEL..FQRHFCREVRE.....
F6P9Y8_DANRE/20-77               ...c-GWREFCELHASTTAREL.AQHYRRFV.......RER..PVQ..-D.V.V.PPE...SFSKQFSAL..FQHHFSCEVAK.....
E3Q1M8_PIG/24-82                 ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G3W753_SARHA/26-84               ....PDWREFCELHAQAAAVDF.AQKFCRFL.......REN..PQY..DT.P.G.AEA...SFSHHFATN..FLDVFSIEVS-r....
D3Z0T9_MOUSE/22-77               ....RGWSDFCEQHAAAAAREL.ARQYWLFA.......RAH..PQP..--.-.P.RAD...LVSLQFAEL..FQRHFCREVRE.....
G1TLV4_RABIT/14-74               ....RGWSDFCELHAVAAAREL.ARQYWRFP.......PQT..PQH..AP.A.A.PPS...SFRLQFTDLlpFQRYFCR----ngar.
H9G672_ANOCA/24-81               ...s-GWNEFCEQHAITTAREL.ARKYLLFV.......NEN..PQH..-E.V.L.AAD...NFSLHFADL..FQQYFRNELK-d....
H9KF89_APIME/51-111              ....PGWIEFCERHARASASDF.AKAFCTYV.......SLN.lPES..ARlN.L.SHH...DFLKKFVES..FCEHFENEY--lr...
G1MAQ2_AILME/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
B3KNV5_HUMAN/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F7DWZ1_MACMU/1-56                ...x----EFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G5BRD6_HETGA/18-76               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
E2QSF1_CANFA/37-94               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVRE.....
F6WSM1_HORSE/5-63                ....PDWRQF-SLHAQADAVEFlAHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
G1P924_MYOLU/24-82               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFSEEVRR.....
H2T7P0_TAKRU/24-66               ....PDWREFCELHARASAADF.ADKFQRFL.......SEN..PCY..DF.P.G.AD-...---------..-----------gcpls
H0XXM5_OTOGA/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFTTN..FLDVFGEEVRR.....
C9JK89_HUMAN/21-79               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
Q4SPM1_TETNG/3-61                ....PDWREFCELHARASAADF.ADKFQRFL.......TEN..PCY..DS.P.G.ADV...SFSQHFAHH..FLECFASALTQ.....
H3CQK3_TETNG/19-77               ....PDWREFCELHARASAADF.ADKFQRFL.......TEN..PCY..DS.P.G.ADV...SFSQHFAHH..FLECFAH----gqrr.
G3QL56_GORGO/24-81               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
F7FFS9_ORNAN/16-73               ....RGWSEFCELHAVATAKEL.AKQYWLFA.......SEH..PHH..-D.L.L.GAE...HFSLQFTDL..FQQYFRHEVR-v....
F1MJV1_BOVIN/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F6UTE1_ORNAN/20-78               ....PDWRDFCALHAQAAAVDF.ARKFCRFL.......RDN..PQY..DT.P.G.AEA...SFSHHFAAN..FLDVFSVEVS-r....
F7HNX1_CALJA/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
H3BDE6_LATCH/2-60                ....PDWKEFCELHAQAAAVDF.AQKFRQFL.......REN..PHY..NA.P.G.AET...SFSQHFADH..FLDFFTSEVS-r....
G1QI22_NOMLE/23-80               ....RGWSEFCDLHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
Q296W8_DROPS/60-120              ....TSWEEFCERHARAAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFSQKFVES..FAVHYDTEFFR.....
B4PT03_DROYA/69-129              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFFK.....
SH2B1_HUMAN/24-82                ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
B4ICF2_DROSE/67-127              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFFK.....
F6S3C2_MONDO/29-87               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
E1ZY46_CAMFO/101-161             ....TGWIEFCERHARASASDF.AKAFCTYV.......NLN.lPES..AR.T.DlPHR...DFLTKFLES..FREHFENEY--lr...
G6D5M7_DANPL/10-70               ...d-GWVEMCERQAKTSAQDF.AKACLQYI.......QTN..SNEaaAR.P.L.SQK...ELLKKFVEC..FSEQFDFEF--gk...
G3THH9_LOXAF/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AET...AFSRRFAEL..FLQHFEAEVAR.....
H3BTK4_HUMAN/24-57               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..A-.-.-.---...---------..-----------g....
H2LPP1_ORYLA/19-77               ....PDWREFCELHARASAADF.ANKFQRFL.......LEN..PCY..DS.P.G.ADT...SFSQHFAHH..FLECFSAALT-q....
H3IC86_STRPU/10-78               ....QGWTEFCETEAHKAAVIF.ARNYRQYMmvaanssANH..PQV..SE.P.M.PKEnptRFAQRFTEH..FFEHFEAEAR-r....
G9KNK2_MUSPF/50-108              ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G3QZH2_GORGO/21-66               .xxx----------------XF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G1SIG7_RABIT/13-68               ...s-AWSDFCELHAVAAAREL.ARQYWRFP.......PQA..PRS..TR.P.L.RPR...A---RFGWL..FQRYFCRDYR-d....
A2RUZ0_DANRE/70-127              ...l-SWTEFCELHARVAAGDF.ARHFRAFL.......QEN..PNY..-S.P.D.SAA...LFCRRFTDR..FVRHFESELE-v....
B0X2Z7_CULQU/66-126              ..gv--WAEFCERHARAASADF.ARSCVHYV.......TNN.lPES..AR.QtV.SHR...DFMRRFIEC..FQEHFEHDF--yr...
H3AZC9_LATCH/15-72               ....RGWKEFCELHAISIAKEL.AKQYWLFV.......NEH..PHH..-D.V.L.AAE...NFSLQFTDL..FQQYFRNEVK-e....
B4K575_DROMO/55-115              ...t-SLEEFCDRHARVAASDF.AKACINYI.......NSNlpPDV..AR.G.I.SHR...NFSIKFVEF..FTVHYAAEFS-k....
E2B5K5_HARSA/60-120              ....TGWIEFCERHARASASDF.AKAFCAYV.......SLN.lPES..ARaN.L.SHR...DFLRKFVES..FCEHFESEY--lr...
G1N121_MELGA/15-72               ....RGWHEFCELHAISTAKEL.ARHYLRFA.......TEH..PHH..-D.L.L.AAE...NFSLRFADL..FQQYFCNEVK-e....
D2A4V7_TRICA/12-72               ...n-SWIEFCERHASVAAQDF.SKSCVQFM.......SLNlsESA..KA.T.I.THK...DFLGKFLET..FAEHFETDF--gk...
H2V1E3_TAKRU/23-80               ....RGWREFCELHAIATARQL.AGHYRSFA.......RER..PQQ..-D.V.L.PPE...LFSKQFTDL..FQQHFCCEVD-k....
B4QVG0_DROSI/66-126              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFFK.....
H9FSN3_MACMU/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
D6RCY9_MOUSE/22-77               ....RGWSDFCEQHAAAAAREL.ARQYWLFA.......RAH..PQP..--.-.P.RAD...LVSLQFAEL..FQRHFCREVRE.....
B3P6D9_DROER/66-126              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFFK.....
H2T7N9_TAKRU/19-77               ....PDWREFCELHARASAADF.ADKFQRFL.......SEN..PCY..DF.P.G.ADV...SFSQHFAHH..FLECFTSALTQ.....
B4GEJ4_DROPE/60-120              ....TSWEEFCERHARAAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFSQKFVES..FAVHYDTEFFR.....
G3W1L1_SARHA/15-72               ....RGWSEFCELHAVATAKEL.AKQYWLFA.......SEH..PHH..-D.L.L.GAD...HFSLQFTDL..FQQYFRHEVRE.....
H3CLY4_TETNG/8-64                ...a-AWTEFCELHARVAAGDF.ARHFRAFL.......LEN..PHY..-S.P.D.SAA...AFCRRFTDR..FVRHFQMEL--g....
H9FSN5_MACMU/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
Q17DJ2_AEDAE/58-118              ..gv--WAEFCERHARAASADF.ARSCVHYI.......TTN.lPES..AR.QtV.SHR...DFMRRFVDC..FQEHFGHDF--dr...
Q7K137_DROME/66-126              ....TSWEEFCERHARVAASDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFFK.....
F7HUD9_CALJA/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
SH2B2_MOUSE/16-74                ....PDWRQFCELHAQVAAVDF.AHKFCRFL.......RDN..PTY..DT.P.D.AGT...SFSRHFAAN..FLAVFSEEVRR.....
D2GVU7_AILME/31-83               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRY-------xm...
B3LYK3_DROAN/67-127              ....TSWEEFCERHAKVAATDF.AKACITYI.......NGNlpPEE..AR.N.I.QHR...SFAQKFVES..FSAHYDTEFF-n....
F6VVV9_MONDO/15-73               ....PDWREFCELHAQAAAVDF.AQKFCRFL.......REN..PQY..DT.P.G.AEA...SFSHHFAAN..FLDVFSVEVS-r....
G7NQG6_MACMU/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G1M5A5_AILME/31-86               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRFLA-----kqm..
H3BYX8_TETNG/23-80               ....RGWREFCELHAIATARQL.AGHYRSFA.......RER..PHQ..-D.V.L.PPE...LFSKQFTDL..FQQHFCCEVD-k....
G5AXB0_HETGA/5-63                ....PDWRQFCELHAQVAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
G3SQP8_LOXAF/15-73               ....PDWRQFCELQAQAAAVDF.AHKFCRFL.......RDN..PTY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
F6V4P5_XENTR/15-73               ....PDWKEFCELHAQAAAVDF.AQKFCRFL.......KEN..PHY..NA.P.G.AET...SFSHHFAAN..FLDFFSFEVS-r....
Q7QFS7_ANOGA/90-150              ...g-TWSEFCERHARAASADF.ARACVNYV.......TNN.lPEV..ARhT.I.SHR...DFMRRFVQC..FESRFEDEFQ-r....
H0XH91_OTOGA/24-82               ....PSWREFCESHARAAALDF.AHRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F4WHU7_ACREC/1-61                ....TGWIEFCERHARASASDF.AKAFCAYV.......SLN.lPES..ARaN.L.SHR...DFLRKFVES..FCEHFESEY--lr...
B4LYY8_DROVI/94-154              ....TSWEEFCDRHARVAASDF.AKACINYI.......NGNlpPEV..AR.S.I.PHR...SFAVKFVEY..FSEHYDTEFFR.....
G9KNK3_MUSPF/1-46                ....-------------AAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
H0Y1V5_OTOGA/26-83               ....RGWSEFCELHAVATAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVRE.....
F7DWZ7_MACMU/1-56                ...x----EFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F6PIB3_MONDO/1-57                ....--WREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
H2Q6W1_PANTR/24-81               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
H2NIN8_PONAB/24-81               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
F7I7H3_CALJA/19-76               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFSEE---kd...
G3U0X8_LOXAF/16-74               ....PDWRQFCELQAQAAAVDF.AHKFCRFL.......RDN..PTY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
F1RKF8_PIG/22-80                 ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
F1PRX4_CANFA/79-137              ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
D2HX27_AILME/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G3RLC3_GORGO/21-79               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......QDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
E2QSF0_CANFA/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
E0VIR8_PEDHC/14-72               ...a-KWADFCDVQAKTVATDL.ANAFCKYS.......SSL..ANN..LQ.T.L.SHK...EFISKFMDF..FIVHFESEIA-k....
H9FSN4_MACMU/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
H9GLW0_ANOCA/24-82               ....PDWREFCEVHAQAAAVDF.AQKFCQFV.......KEN..PHY..DT.P.G.AEA...SFSHHFAAN..FLDVFGLEVN-r....
Q4SUR2_TETNG/18-74               ...l-SWTEFCELHARVAAGDF.ARHFRAFL.......LEN..PHY..-S.P.D.SAA...AFCRRFTDR..FVRHFQMEL--g....
G1RA91_NOMLE/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSHHFAAN..FLDVFGEEVRR.....
H3BX30_TETNG/23-80               ....RGWREFCELHAIATARQL.AGHYRSFA.......RER..PHQ..-D.V.L.PPE...LFSKQFTDL..FQQHFCCEVD-k....
D3Z3Y5_MOUSE/22-77               ....RGWSDFCEQHAAAAAREL.ARQYWLFA.......RAH..PQP..--.-.P.RAD...LVSLQFAEL..FQRHFCREVRE.....
H2PLT4_PONAB/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLEVFGEEVRR.....
H2T7N8_TAKRU/19-77               ....PDWREFCELHARASAADF.ADKFQRFL.......SEN..PCY..DF.P.G.ADV...SFSQHFAHH..FLECFTSALTQ.....
G3P6B2_GASAC/19-77               ....PDWREFCELHARASAADF.ADKFQRFL.......LEN..PCY..DS.P.G.ADA...SFSQHFARH..FLECFSAALT-q....
F5GY53_HUMAN/64-122              ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
G3W1L2_SARHA/15-72               ....RGWSEFCELHAVATAKEL.AKQYWLFA.......SEH..PHH..-D.L.L.GAD...HFSLQFTDL..FQQYFRHEVR-d....
H2LES0_ORYLA/24-81               ....RGWREFCELHAFATARQL.AGHYRSFA.......RER..PQH..-D.V.V.PPE...AFSKQFSDL..FQQHFCCEVD-k....
H3AF52_LATCH/15-73               ....PSWKEFCEIHAHAAAVEF.ARRFRTFL.......SEN..PQY..AG.P.G.AEA...TFSKRFAEH..FMEQFEVEVN-r....
F1RFI0_PIG/24-82                 ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F6RGT3_MACMU/21-79               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
F7ISI1_CALJA/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G3S1G9_GORGO/16-73               ...s-AWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
E9QI81_DANRE/70-109              ...l-SWTEFCELHARVAAGDF.ARHFRAFL.......QEN..PNY..-S.P.D.SAA...LF-------..-----------.....
H9JUP9_BOMMO/10-70               ...d-GWVEYCEREARAAAQEL.AKGCLPYI.......QPGheAAA..QP.P.T.THK...DLLKKFIDC..FTEHFDIEI--gk...
F6PIB6_MONDO/1-57                ....--WREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
SH2B1_MOUSE/24-82                ....PSWQEFCESHARAAALDL.ARRFRLYL.......ASH..PQY..AE.P.G.AEA...AFSGRFAEL..FLQHFEAEVAR.....
H0Z7W7_TAEGU/4-61                ....RGWHEFCELHAISTAKEL.ARHYLRFA.......TEH..PHH..-D.L.L.AAE...NFSVQFTDL..FQQYFCHELR-i....
F7C8E3_HORSE/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G3NSJ6_GASAC/29-86               ....RGWREFCELHAIATARQL.AGHYRIFA.......RER..PQH..-D.A.L.PPE...TFSKQFTDL..FQQHFSCEVD-k....
F1LM14_RAT/16-74                 ....PDWRQFCELHAQVAAVDF.AHKFCRFL.......RDN..PTY..DT.P.D.AGT...SFSRHFAAN..FLAVFSEEVRR.....
H2RN85_TAKRU/24-81               ...l-SWTEFCELHARVAAGDF.ARHFRAFL.......LEN..PHY..-S.P.D.SAA...AFCRRFTDR..FVRHFQSELE-g....
G3S3N8_GORGO/35-80               rglp-----------------F.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
H2V1E4_TAKRU/23-80               ....RGWREFCELHAIATARQL.AGHYRSFA.......RER..PQQ..-D.V.L.PPE...LFSKQFTDL..FQQHFCCEVD-k....
E2RSS6_CANFA/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
E3WMU5_ANODA/100-160             ...g-TWTEFCERHARAASADF.ARACVNYV.......TSN.lPEV..ARhT.I.SHR...DFMRRFVQC..FEEHFEHDFH-r....
F1NFS1_CHICK/19-77               ....PDWREFCELHAQAAAVDF.AQKFCQFL.......KEN..PHY..DT.P.G.AEA...SFSHHFAAN..FLDIFSVEVS-r....
G1U818_RABIT/12-70               ....PDWREFCELHAQVAAVDF.AHKFCRFL.......QEH..PAY..DT.P.D.AGA...SFSRHFAAN..FLDAFGEEVRR.....
G3I7M3_CRIGR/24-82               ....PSWQEFCESHARAAALDL.ARRFRLYL.......ASH..PQY..AE.P.G.AEA...AFSGRFAEL..FLQHFEAEVAR.....
E1BE90_BOVIN/28-85               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVRE.....
H3BVF6_HUMAN/24-63               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...---------..-----------a....
F1RMZ2_PIG/26-83                 ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PHH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVRE.....
G3WFN7_SARHA/25-83               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
H0Z1Y1_TAEGU/4-62                ....PDWREFCKLHAQAAAVDF.AQKFCQFL.......KEN..PHY..DT.P.G.AET...SFSHHFTAN..FLDIFSLEVS-r....
B4JYY2_DROGR/56-116              ...t-TWEEFCDRHARVAASDF.AKACITFI.......NGSlpPEV..AR.N.I.PYH...SFAAKYVEY..FSQHYDTEFFR.....
F6V8B6_CALJA/19-77               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFSEEVRR.....
G1PET6_MYOLU/24-82               ....PSWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
SH2B2_RAT/16-74                  ....PDWRQFCELHAQVAAVDF.AHKFCRFL.......RDN..PTY..DT.P.D.AGT...SFSRHFAAN..FLAVFSEEVRR.....
H3BWZ9_TETNG/8-64                ...a-AWTEFCELHARVAAGDF.ARHFRAFL.......LEN..PHY..-S.P.D.SAA...AFCRRFTDR..FVRHFQMEL--g....
H0VAD8_CAVPO/16-74               ...p-TWRQFCELHAQVAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDAFGEEVRR.....
F7ISL7_CALJA/10-68               ...g-SWREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
F6W719_MACMU/24-81               ....RGWSEFCELHAVAAAREL.ARQYWLFA.......REH..PQH..-A.P.L.RAE...LVSLQFTDL..FQRYFCREVR-d....
E1BXL2_CHICK/15-72               ....RGWHEFCELHAISTAKEL.ARHYLRFA.......TEH..PHH..-D.L.L.AAE...NFSLRFADL..FQQYFCNE---han..
SH2B2_HUMAN/21-79                ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......RDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
#=GR SH2B2_HUMAN/21-79     SS    ....--HHHHHHHHHHHHHHHH.HHHHHHHH.......HH-..GGG..-S.T.T.HHH...HHHHHHHHH..HHHHHHHHHHH.....
F6PIA5_MONDO/1-57                ....--WREFCESHARAAALDF.ARRFRLYL.......ASH..PQY..AG.P.G.AEA...AFSRRFAEL..FLQHFEAEVAR.....
G1MWL7_MELGA/20-78               ....PDWREFCELHAQAAAVDF.AQKFCQFL.......KEN..PHY..DT.P.G.AEA...SFSHHFAAN..FLDIFSLEVS-r....
A4QN29_XENTR/30-87               ....QGWNEFCKLHAISTAREL.AKQYWLFA.......NQN..PQH..-D.I.L.AAE...IFSLHFTDL..FQQYFRNEVRE.....
SH2B3_MOUSE/22-77                ....RGWSDFCEQHAAAAAREL.ARQYWLFA.......RAH..PQP..--.-.P.RAD...LVSLQFAEL..FQRHFCREVRE.....
E7FFS4_DANRE/18-76               ....PDWKEFCELHARASAADF.AYKFRRFI.......TEN..PCY..DS.P.G.ADV...SFSQHFAQH..FLTCFSAALD-q....
G3RMX7_GORGO/27-85               ....PDWRQFCELHAQAAAVDF.AHKFCRFL.......QDN..PAY..DT.P.D.AGA...SFSRHFAAN..FLDVFGEEVRR.....
H3BDE5_LATCH/15-73               ....PDWKEFCELHAQAAAVDF.AQKFRQFL.......REN..PHY..NA.P.G.AET...SFSQHFADH..FLDFFTSEVS-r....
#=GC SS_cons                     ....--HHHHHHHHHHHHHHHH.HHHHHHHH.......HH-..GGG..-S.T.T.HHH...HHHHHHHHH..HHHHHHHHHHH.....
#=GC seq_cons                    .....uWcEFCEhHApAAAhDF.A++Fphal.......ppp..Ppa..ss.P.s.uts...uFS++Fs-h..FhpaFptEVt......
//
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