GenomeNet

Database: Pfam
Entry: Pinin_SDK_memA
LinkDB: Pinin_SDK_memA
Original site: Pinin_SDK_memA 
#=GF ID   Pinin_SDK_memA
#=GF AC   PF04696.8
#=GF DE   pinin/SDK/memA/ protein conserved region
#=GF PI   pinin_SDK_memA; 
#=GF AU   Waterfield DI, Finn RD
#=GF SE   Pfam-B_4141 (release 7.5)
#=GF GA   25.00 25.00;
#=GF TC   25.70 25.70;
#=GF NC   24.50 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8922384
#=GF RT   Characterization of pinin, a novel protein associated with the
#=GF RT   desmosome-intermediate filament complex. 
#=GF RA   Ouyang P, Sugrue SP; 
#=GF RL   J Cell Biol 1996;135:1027-1042.
#=GF RN   [2]
#=GF RM   9447706
#=GF RT   Evidence that 'pinin', reportedly a differentiation-specific
#=GF RT   desmosomal protein, is actually a widespread nuclear protein. 
#=GF RA   Brandner JM, Reidenbach S, Franke WW; 
#=GF RL   Differentiation 1997;62:119-127.
#=GF RN   [3]
#=GF RM   10095061
#=GF RT   memA/DRS, a putative mediator of multiprotein complexes, is
#=GF RT   overexpressed in the metastasizing human melanoma cell lines BLM
#=GF RT   and MV3. 
#=GF RA   Degen WG, Agterbos MA, Muyrers JP, Bloemers HP, Swart GW; 
#=GF RL   Biochim Biophys Acta 1999;1444:384-394.
#=GF DR   INTERPRO; IPR006786;
#=GF CC   Members of this family have very varied localisations within the
#=GF CC   eukaryotic cell. pinin is known to localise at the desmosomes
#=GF CC   and is implicated in anchoring intermediate filaments to the
#=GF CC   desmosomal plaque [1].  SDK2/3 is a dynamically localised
#=GF CC   nuclear protein thought to be involved in modulation of
#=GF CC   alternative pre-mRNA splicing [2].  memA is a tumour marker
#=GF CC   preferentially expressed in human melanoma cell lines.  A common
#=GF CC   feature of the members of this family is that they may all
#=GF CC   participate in regulating protein-protein interactions [3].
#=GF SQ   266
#=GS E1ZPD3_CHLVA/192-262   AC E1ZPD3.1
#=GS D0NQL9_PHYIT/148-284   AC D0NQL9.1
#=GS Q06SM4_CANFA/134-264   AC Q06SM4.1
#=GS F4NVD8_BATDJ/203-331   AC F4NVD8.1
#=GS I1KUJ3_SOYBN/158-266   AC I1KUJ3.1
#=GS F4WUF9_ACREC/142-276   AC F4WUF9.1
#=GS G7IK12_MEDTR/67-175    AC G7IK12.1
#=GS E4X7C9_OIKDI/98-227    AC E4X7C9.1
#=GS Q297F1_DROPS/111-241   AC Q297F1.2
#=GS C3XZH2_BRAFL/145-277   AC C3XZH2.1
#=GS F8NQD5_SERL9/25-126    AC F8NQD5.1
#=GS B3S6G1_TRIAD/132-264   AC B3S6G1.1
#=GS I1FLA0_AMPQE/116-248   AC I1FLA0.1
#=GS H9KK89_APIME/176-307   AC H9KK89.1
#=GS C1E364_MICSR/106-244   AC C1E364.1
#=GS C5LWI4_PERM5/14-102    AC C5LWI4.1
#=GS A7RWZ2_NEMVE/131-261   AC A7RWZ2.1
#=GS E4YYQ9_OIKDI/98-235    AC E4YYQ9.1
#=GS F4HZI8_ARATH/155-273   AC F4HZI8.1
#=GS C6HC04_AJECH/80-200    AC C6HC04.1
#=GS C5FMH3_ARTOC/80-203    AC C5FMH3.1
#=GS G2YSP8_BOTF4/1-36      AC G2YSP8.1
#=GS B4GE54_DROPE/111-241   AC B4GE54.1
#=GS F4P8P6_BATDJ/203-331   AC F4P8P6.1
#=GS H1VSR9_COLHI/96-217    AC H1VSR9.1
#=GS Q3TUQ5_MOUSE/134-264   AC Q3TUQ5.1
#=GS H6C3L5_EXODN/18-157    AC H6C3L5.1
#=GS Q0U384_PHANO/62-148    AC Q0U384.2
#=GS F7HGA5_MACMU/134-264   AC F7HGA5.1
#=GS G1LB43_AILME/134-264   AC G1LB43.1
#=GS Q3SYT5_BOVIN/134-264   AC Q3SYT5.1
#=GS H9FVZ6_MACMU/134-264   AC H9FVZ6.1
#=GS B9FAS9_ORYSJ/90-226    AC B9FAS9.1
#=GS Q2UB34_ASPOR/79-153    AC Q2UB34.1
#=GS D7FXJ8_ECTSI/433-567   AC D7FXJ8.1
#=GS F6SEN2_CALJA/134-264   AC F6SEN2.1
#=GS G1X429_ARTOA/54-171    AC G1X429.1
#=GS Q4XI84_PLACH/13-145    AC Q4XI84.1
#=GS E3JQJ6_PUCGT/68-175    AC E3JQJ6.2
#=GS A6MZL8_ORYSI/1-57      AC A6MZL8.1
#=GS H3A9C4_LATCH/135-265   AC H3A9C4.1
#=GS H2WFE5_CAEJA/154-291   AC H2WFE5.1
#=GS G2RBS7_THITE/76-151    AC G2RBS7.1
#=GS G7MXN2_MACMU/134-264   AC G7MXN2.1
#=GS A1DIQ6_NEOFI/81-201    AC A1DIQ6.1
#=GS G7DUX9_MIXOS/67-171    AC G7DUX9.1
#=GS F4HZI7_ARATH/155-273   AC F4HZI7.1
#=GS Q7RZL6_NEUCR/140-262   AC Q7RZL6.1
#=GS O73619_XENLA/136-266   AC O73619.1
#=GS D2H488_AILME/134-264   AC D2H488.1
#=GS B3NZL5_DROER/123-253   AC B3NZL5.1
#=GS Q2UB33_ASPOR/1-36      AC Q2UB33.1
#=GS A6RVD4_BOTFB/95-216    AC A6RVD4.1
#=GS PININ_MOUSE/133-263    AC O35691.4
#=GS A7F7S1_SCLS1/95-170    AC A7F7S1.1
#=GS F0XSI6_GROCL/134-259   AC F0XSI6.1
#=GS G4LXC1_SCHMA/99-206    AC G4LXC1.1
#=GS E9ITD9_SOLIN/142-272   AC E9ITD9.1
#=GS Q1ZXG7_DICDI/110-247   AC Q1ZXG7.1
#=GS Q75I81_ORYSJ/143-251   AC Q75I81.1
#=GS H0EWI3_GLAL7/82-201    AC H0EWI3.1
#=GS A0CSJ7_PARTE/74-208    AC A0CSJ7.1
#=GS A1C824_ASPCL/81-201    AC A1C824.1
#=GS B8NPV0_ASPFN/80-200    AC B8NPV0.1
#=GS E1C2F2_CHICK/134-264   AC E1C2F2.1
#=GS G4ZTS2_PHYSP/147-282   AC G4ZTS2.1
#=GS E3Q855_COLGM/98-219    AC E3Q855.1
#=GS G9KHJ2_MUSPF/140-270   AC G9KHJ2.1
#=GS F8MN83_NEUT8/139-261   AC F8MN83.1
#=GS F4HZI6_ARATH/155-296   AC F4HZI6.1
#=GS H2NL36_PONAB/134-264   AC H2NL36.1
#=GS G3PFS1_GASAC/138-239   AC G3PFS1.1
#=GS B7PSH3_IXOSC/82-217    AC B7PSH3.1
#=GS Q52KX2_XENLA/136-266   AC Q52KX2.1
#=GS H0V2E7_CAVPO/134-264   AC H0V2E7.1
#=GS A8X901_CAEBR/153-285   AC A8X901.2
#=GS I1RRL6_GIBZE/90-211    AC I1RRL6.1
#=GS B0W8H0_CULQU/138-268   AC B0W8H0.1
#=GS F0UB48_AJEC8/80-200    AC F0UB48.1
#=GS B0XVC0_ASPFC/80-201    AC B0XVC0.1
#=GS B8LRA9_PICSI/161-297   AC B8LRA9.1
#=GS B4HJU5_DROSE/124-254   AC B4HJU5.1
#=GS E3RQY4_PYRTT/63-183    AC E3RQY4.1
#=GS PININ_BOVIN/135-265    AC P79122.3
#=GS A9US36_MONBE/932-1062  AC A9US36.1
#=GS F7VYJ0_SORMK/138-260   AC F7VYJ0.1
#=GS A0JMJ5_DANRE/138-268   AC A0JMJ5.1
#=GS C0PUE4_SALSA/130-260   AC C0PUE4.1
#=GS E9F0U3_METAR/73-195    AC E9F0U3.1
#=GS D4D5Z1_TRIVH/81-201    AC D4D5Z1.1
#=GS F8QIR1_SERL3/25-126    AC F8QIR1.1
#=GS Q4P668_USTMA/147-255   AC Q4P668.1
#=GS G7PA51_MACFA/134-264   AC G7PA51.1
#=GS D8RF14_SELML/126-255   AC D8RF14.1
#=GS B3LBW1_PLAKH/78-213    AC B3LBW1.1
#=GS I1MDR5_SOYBN/160-296   AC I1MDR5.1
#=GS A0ED16_PARTE/79-208    AC A0ED16.1
#=GS I1MDR9_SOYBN/160-270   AC I1MDR9.1
#=GS H9HCZ4_ATTCE/142-273   AC H9HCZ4.1
#=GS Q75I82_ORYSJ/143-279   AC Q75I82.1
#=GS B6HJI9_PENCW/130-250   AC B6HJI9.1
#=GS Q66HU9_DANRE/136-266   AC Q66HU9.1
#=GS G7YF63_CLOSI/488-620   AC G7YF63.1
#=GS F0X0U9_9STRA/152-290   AC F0X0U9.1
#=GS D8SD82_SELML/126-260   AC D8SD82.1
#=GS D6WR51_TRICA/173-248   AC D6WR51.1
#=GS G3U4C9_LOXAF/134-265   AC G3U4C9.1
#=GS I1MDR8_SOYBN/160-268   AC I1MDR8.1
#=GS B9GF79_POPTR/158-294   AC B9GF79.1
#=GS F2TWA7_SALS5/92-221    AC F2TWA7.1
#=GS H2T0C8_TAKRU/138-268   AC H2T0C8.1
#=GS PININ_HUMAN/134-264    AC Q9H307.4
#=GS F1N3M1_BOVIN/134-265   AC F1N3M1.1
#=GS F4Q651_DICFS/188-313   AC F4Q651.1
#=GS A8K964_HUMAN/134-264   AC A8K964.1
#=GS H3G2R8_PRIPA/111-248   AC H3G2R8.1
#=GS F5HCF2_CRYNB/38-147    AC F5HCF2.1
#=GS D5GLI6_TUBMM/53-181    AC D5GLI6.1
#=GS I1BYQ3_RHIO9/44-174    AC I1BYQ3.1
#=GS A8QFZ8_BRUMA/127-264   AC A8QFZ8.1
#=GS F1SIQ0_PIG/134-264     AC F1SIQ0.1
#=GS Q01CL0_OSTTA/236-370   AC Q01CL0.1
#=GS C5WNT6_SORBI/151-287   AC C5WNT6.1
#=GS G3YAF0_ASPNA/74-189    AC G3YAF0.1
#=GS B9SPL7_RICCO/122-258   AC B9SPL7.1
#=GS B9PSF0_TOXGO/99-232    AC B9PSF0.1
#=GS G2QEF9_THIHA/102-223   AC G2QEF9.1
#=GS G3SBD1_GORGO/134-264   AC G3SBD1.1
#=GS G1NIY0_MELGA/97-227    AC G1NIY0.2
#=GS C5JJC6_AJEDS/78-152    AC C5JJC6.1
#=GS Q7Q0H5_ANOGA/161-291   AC Q7Q0H5.5
#=GS Q4PFS6_USTMA/24-132    AC Q4PFS6.1
#=GS C4WXX3_ACYPI/34-164    AC C4WXX3.1
#=GS E1FXI6_LOALO/127-263   AC E1FXI6.1
#=GS Q4XUT9_PLACH/5-141     AC Q4XUT9.1
#=GS F2S1R3_TRIT1/81-202    AC F2S1R3.1
#=GS B8AQD5_ORYSI/223-359   AC B8AQD5.1
#=GS F1PMU1_CANFA/134-264   AC F1PMU1.1
#=GS H2MTK5_ORYLA/136-235   AC H2MTK5.1
#=GS D4B496_ARTBC/81-221    AC D4B496.1
#=GS A6R895_AJECN/80-200    AC A6R895.1
#=GS E9GS06_DAPPU/148-278   AC E9GS06.1
#=GS F6RBN4_XENTR/136-258   AC F6RBN4.1
#=GS YDG2_SCHPO/63-197      AC Q10492.1
#=GS C5GAA9_AJEDR/79-153    AC C5GAA9.1
#=GS A9RYX2_PHYPA/173-310   AC A9RYX2.1
#=GS H0ZP82_TAEGU/134-266   AC H0ZP82.1
#=GS B4FA58_MAIZE/149-257   AC B4FA58.1
#=GS F4RWC8_MELLP/56-165    AC F4RWC8.1
#=GS Q95ZQ5_CAEEL/152-282   AC Q95ZQ5.1
#=GS PININ_CANFA/134-264    AC P79149.3
#=GS A7AP84_BABBO/68-200    AC A7AP84.1
#=GS G0S5L3_CHATD/129-230   AC G0S5L3.1
#=GS H2T0C9_TAKRU/145-275   AC H2T0C9.1
#=GS F2PQW5_TRIEC/81-202    AC F2PQW5.1
#=GS B6TFH8_MAIZE/149-286   AC B6TFH8.1
#=GS D8QJ48_SCHCM/39-143    AC D8QJ48.1
#=GS F6RIG9_CIOIN/134-274   AC F6RIG9.2
#=GS B4K4F1_DROMO/119-249   AC B4K4F1.1
#=GS B3MX73_DROAN/124-254   AC B3MX73.1
#=GS G6DTH5_DANPL/129-259   AC G6DTH5.1
#=GS C0NWA4_AJECG/80-200    AC C0NWA4.1
#=GS A8N524_COPC7/45-143    AC A8N524.1
#=GS G1SGZ7_RABIT/134-264   AC G1SGZ7.1
#=GS Q4RP18_TETNG/138-268   AC Q4RP18.1
#=GS Q5AWN9_EMENI/78-193    AC Q5AWN9.1
#=GS A2Q483_MEDTR/157-293   AC A2Q483.1
#=GS Q2HA23_CHAGB/103-179   AC Q2HA23.1
#=GS Q8IFW3_DROME/124-254   AC Q8IFW3.1
#=GS G0N976_CAEBE/149-286   AC G0N976.1
#=GS Q6DJ99_XENTR/136-266   AC Q6DJ99.1
#=GS F1QT45_DANRE/135-265   AC F1QT45.2
#=GS B4MC87_DROVI/118-248   AC B4MC87.1
#=GS G1QVI0_NOMLE/134-264   AC G1QVI0.1
#=GS B6KN82_TOXGO/99-232    AC B6KN82.1
#=GS F2SRY6_TRIRC/81-201    AC F2SRY6.1
#=GS B6JZG6_SCHJY/57-165    AC B6JZG6.1
#=GS A2VDA0_XENLA/136-266   AC A2VDA0.1
#=GS F6SYF0_ORNAN/134-264   AC F6SYF0.1
#=GS D3AVV0_POLPA/141-239   AC D3AVV0.1
#=GS F6S4U1_CALJA/134-264   AC F6S4U1.1
#=GS F6TER4_HORSE/73-200    AC F6TER4.1
#=GS H3HBD4_PHYRM/112-247   AC H3HBD4.1
#=GS A5JZD6_PLAVS/79-216    AC A5JZD6.1
#=GS D7ST85_VITVI/164-308   AC D7ST85.1
#=GS G2X7W0_VERDV/91-212    AC G2X7W0.1
#=GS I1KUJ2_SOYBN/158-294   AC I1KUJ2.1
#=GS G5C811_HETGA/134-264   AC G5C811.1
#=GS Q9VH84_DROME/124-254   AC Q9VH84.1
#=GS Q7SXA7_DANRE/144-274   AC Q7SXA7.1
#=GS Q9CV89_MOUSE/134-235   AC Q9CV89.1
#=GS G1TIE1_RABIT/137-267   AC G1TIE1.1
#=GS Q501Y9_DANRE/144-274   AC Q501Y9.1
#=GS G3J6A1_CORMM/124-255   AC G3J6A1.1
#=GS E9D1D1_COCPS/78-199    AC E9D1D1.1
#=GS B0DCM9_LACBS/44-148    AC B0DCM9.1
#=GS Q9C5G2_ARATH/155-291   AC Q9C5G2.1
#=GS H3DHJ7_TETNG/140-270   AC H3DHJ7.1
#=GS G9NM55_HYPAI/89-212    AC G9NM55.1
#=GS G5DYV4_9PIPI/54-183    AC G5DYV4.1
#=GS H3HZM4_STRPU/115-245   AC H3HZM4.1
#=GS G0R7E1_HYPJQ/6-128     AC G0R7E1.1
#=GS B6TZE8_MAIZE/147-283   AC B6TZE8.1
#=GS G3IJF5_CRIGR/134-264   AC G3IJF5.1
#=GS D3ZAY8_RAT/134-264     AC D3ZAY8.1
#=GS I1MDR6_SOYBN/160-268   AC I1MDR6.1
#=GS E6ZPQ7_SPORE/88-188    AC E6ZPQ7.1
#=GS G9MMK9_HYPVG/90-213    AC G9MMK9.1
#=GS G1NYB2_MYOLU/134-264   AC G1NYB2.1
#=GS E3LU00_CAERE/153-277   AC E3LU00.1
#=GS D6WR51_TRICA/130-164   AC D6WR51.1
#=GS F7DZE3_MONDO/134-264   AC F7DZE3.1
#=GS I1KUJ4_SOYBN/149-257   AC I1KUJ4.1
#=GS D7KCN8_ARALL/155-291   AC D7KCN8.1
#=GS A0DVE5_PARTE/82-211    AC A0DVE5.1
#=GS C5PDN7_COCP7/90-211    AC C5PDN7.1
#=GS Q16IW4_AEDAE/136-266   AC Q16IW4.1
#=GS H0X4P8_OTOGA/73-144    AC H0X4P8.1
#=GS E6R788_CRYGW/38-147    AC E6R788.1
#=GS C4JUS9_UNCRE/81-202    AC C4JUS9.1
#=GS Q5DEZ4_SCHJA/1-122     AC Q5DEZ4.1
#=GS E3WNS4_ANODA/160-290   AC E3WNS4.1
#=GS E0V921_PEDHC/127-257   AC E0V921.1
#=GS F0WYF2_9STRA/152-289   AC F0WYF2.1
#=GS A8JQW3_DROME/124-254   AC A8JQW3.1
#=GS Q4N6H7_THEPA/76-215    AC Q4N6H7.1
#=GS I1GP09_BRADI/145-281   AC I1GP09.1
#=GS H9IU48_BOMMO/131-261   AC H9IU48.1
#=GS E5A184_LEPMJ/62-183    AC E5A184.1
#=GS A0EHT4_PARTE/91-224    AC A0EHT4.1
#=GS B4NK05_DROWI/124-254   AC B4NK05.1
#=GS Q06SM5_CANFA/132-262   AC Q06SM5.1
#=GS B8LY10_TALSN/72-194    AC B8LY10.1
#=GS Q9XI49_ARATH/155-229   AC Q9XI49.1
#=GS E5S1W1_TRISP/286-405   AC E5S1W1.1
#=GS C1N366_MICPC/80-217    AC C1N366.1
#=GS G3RRD6_GORGO/134-264   AC G3RRD6.1
#=GS Q4WZH5_ASPFU/80-201    AC Q4WZH5.1
#=GS PININ_PONAB/134-264    AC Q5R5X0.1
#=GS B4JHQ0_DROGR/119-249   AC B4JHQ0.1
#=GS Q0C890_ASPTN/100-215   AC Q0C890.1
#=GS I1PEP6_ORYGL/91-227    AC I1PEP6.1
#=GS Q5KGJ2_CRYNJ/38-147    AC Q5KGJ2.1
#=GS Q7RS89_PLAYO/66-202    AC Q7RS89.1
#=GS F9FVI9_FUSOF/649-770   AC F9FVI9.1
#=GS E2C475_HARSA/143-273   AC E2C475.1
#=GS E2AQ25_CAMFO/124-254   AC E2AQ25.1
#=GS F2TDE3_AJEDA/79-199    AC F2TDE3.1
#=GS B6Q6P3_PENMQ/86-208    AC B6Q6P3.1
#=GS O73620_XENLA/136-266   AC O73620.1
#=GS G4UPL0_NEUT9/139-261   AC G4UPL0.1
#=GS E4V421_ARTGP/82-203    AC E4V421.1
#=GS H2Q879_PANTR/134-264   AC H2Q879.1
#=GS A4RUH1_OSTLU/22-157    AC A4RUH1.1
#=GS C5LNS1_PERM5/132-216   AC C5LNS1.1
#=GS E9E1H7_METAQ/73-148    AC E9E1H7.1
#=GS G4N4U0_MAGO7/146-267   AC G4N4U0.1
#=GS B7FJX3_MEDTR/157-269   AC B7FJX3.1
#=GS F6SYD1_ORNAN/134-264   AC F6SYD1.1
#=GS B4PVD7_DROYA/123-253   AC B4PVD7.1
#=GS C5LAZ6_PERM5/130-228   AC C5LAZ6.1
#=GS C9SVI1_VERA1/91-212    AC C9SVI1.1
#=GS F0ZF67_DICPU/157-291   AC F0ZF67.1
#=GS G3T2M3_LOXAF/134-264   AC G3T2M3.1
#=GS A9TTB0_PHYPA/157-234   AC A9TTB0.1
#=GS D8UC89_VOLCA/797-903   AC D8UC89.1
E1ZPD3_CHLVA/192-262              ......envd----VK.RRNKR.....LFG.A.I.L.G.TLQRFSR..E..E..EQAk...........tTA....AAQ..RR....AELERKA......EE...KKAE.E....G.RR.L...R....Q....QAR....D.EMR....Q.--....-.-....--.---..--.--..--...-....--..-....-.-...-....---.---------.-........-.....-..------.........------------------.-----mrya............................
D0NQL9_PHYIT/148-284              ......aqkd----GI.ARSRR.....MFG.A.L.M.G.HLGKAKR..Q..I..EKD.............TD....LFK..RQ....DTKQHEA......EQ...REKK.Q....S.QN.L...E....I....QARyeaeV.ARL....E.AS....I.A....RT.ELD..RS.EQ..IT...R....AK..L....E.H...L....QML.RKSASQSKF.L........V.....T..IASPPI.........YYLPAKHTKETKELVAAS.ME---aheak...........................
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D4D5Z1_TRIVH/81-201               ........rd---EER.KRGRR.....LFG.A.L.L.G.TLSQSSS..-..-..---.............TP....AQR..KR....SEIDKKQ......QA...KLEL.Q....D.KE.Y...N....E....LTK....K.KYE....D.--....-.-....LM.ASR..RK.DQ..AL...Y....DS..Q....S.A...E....IRH.SNKLAMAHF.L........R.....T..KAEPPL.........YYRPWYLRPQDETKIQSQ.IAEA-k...............................
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Q75I82_ORYSJ/143-279              .........e-DQSLV.KRNKR.....MLG.K.L.LvG.TLEKFQQ..E..D..KKLs...........nTE....AYM..RR....SEVQRKA......DQ...KARE.E....S.ER.L...R....Q....QER....E.QAI....E.KR....K.R....DM.MLR..AR.VA..AK...A....EE..K....R.L...EllymQWA.EHHKKLSNF.L........R.....T..TAEPPI.........YYMPAKPI----------.-----iddpaiaeenkeka..................
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H2Q879_PANTR/134-264              ..........MDEKGK.QRNRR.....IFG.L.L.M.G.TLQKFKQ..E..S..TVA.............TE....RQK..RR....QEIEQKL......EV...QAEE.E....R.KQ.V...E....N....ERR....E.LFE....E.RR....A.K....QT.ELR..LL.EQ..KV...E....LA..Q....L.Q...E....EWN.EHNAKIIKY.I........R.....T..KTKPHL.........FYIPGRMCPATQKLIEES.QRKMN................................
A4RUH1_OSTLU/22-157               ........ka---EAG.QRERR.....LFA.G.L.L.G.TLRKSKS..N..I..EEK............eKE....VLA..KR....KSIEAAV......SG...KNEE.I....S.RE.L...K....E....AQY....K.AFL....E.KReadeR.K....KF.ELD..LK.FK..ET...E....GA..L....I.E...A....EYE.EMKSKIHDGgI........L.....T..TTEPVL.........VYKPKNPTSED-------.-----aaasqmslekld....................
C5LNS1_PERM5/132-216              ........ir---ESM.KRNRR.....MFG.N.L.L.G.YLGSAKQrlE..S..DRK.............RD....ATQ..RQ....EECAQRV......EA...KLAR.Q....R.NN.L...R....E....IRR....L.EWE....E.RR....-.K....QD.RER..LI.EQ..KI...A....--..-....-.-...-....---.---------.-........-.....-..------.........------------------.-----sipy............................
E9E1H7_METAQ/73-148               ........at--QEEK.KRGKR.....LFG.G.L.L.S.TLSQTST..-..-..---.............NS....QHK..RR....QEIERRQ......QE...RMQK.Q....R.DE.D...D....K....KRA....D.KVA....R.IK....E.T....--.---..--.--..--...-....--..-....-.-...-....---.---------.-........-.....-..------.........------------------.-----riveqidfeeev....................
G4N4U0_MAGO7/146-267              .........f-SQEEK.KRGQR.....LFG.G.L.L.S.TLSQKPP..-..-..---.............--....--G..RR....QPVERKQ......HE...KTQQ.R....K.DE.D...N....R....RKA....-.EIQ....E.KL....A.K....LN.RKR..KI.QQ..IK...L....DE..Q....T.M...H....ARH.DDMLAKAYS.L........R.....T..KARPQL.........YYRPWELTSEEEDIIDEQ.VRDA-kn..............................
B7FJX3_MEDTR/157-269              .........e-DPSLV.NRNKR.....MLG.Q.L.L.G.TLEKFRK..E..D..KQLs...........gTE....AFM..RR....SNSLQRA......EQ...RARE.E....R.EQ.I...A....E....KRR....R.DLT....L.RA....-.-....--.RVA..AK.TE..EK...Q....LE..L....L.F...L....RWS.EHHKRLSNF.I........R.....T..KAEPPI.........YYLPNK------------.-----p...............................
F6SYD1_ORNAN/134-264              ..........MDEKGK.QRNRR.....IFG.L.L.M.G.TLQKFKQ..E..S..TVA.............TE....RQK..RR....QEIEQKL......EV...QAEE.E....R.KQ.V...E....N....ERR....E.LFE....E.RR....A.K....QT.ELR..LL.EQ..KV...E....LA..Q....L.Q...E....EWN.EHNSKIIKY.I........R.....T..KTKPHL.........FYIPGRMCPATQKLIDES.QRKL-n...............................
B4PVD7_DROYA/123-253              ..........TDSESR.ARNRR.....MFG.S.L.L.G.TLQKFCQ..E..E..SRL.............KS....KED..KK....AEIDRKV......EK...QELQ.E....R.AM.L...R....K....QRE....T.LFL....D.RK....K.K....QF.EIR..RL.EY..KM...A....RM..K....D.F...K....AWE.ATMLNAKNN.I........R.....T..KTKPHL.........FFRPKVHSPRTEKLLSKS.KSEAD................................
C5LAZ6_PERM5/130-228              .......qir---ESM.KRNRR.....MFG.N.L.L.G.YLGSAKQrlE..S..DRK.............RD....ATQ..RQ....EECAQRV......EA...KLAR.Q....R.NN.L...R....E....IRR....L.EWE....E.RR....K.Q....DR.--E..RL.EQ..VL...K....EM..E....A.K...K....---.---------.-........-.....-..------.........------------------.-----iellkirlqshy....................
C9SVI1_VERA1/91-212               ........sk--DEEK.KRGKR.....LFG.G.L.L.G.TLNQSGG..-..-..---.............GA....QLK..RR....REIEQRQ......QE...RVQK.Q....K.LE.A...E....K....RS-....-.--A....E.RL....S.R....IT.QVR..RA.EQ..IN...F....EE..K....V.M...K....TRH.ANMLARAHS.L........Q.....T..KAEPRI.........YYQPWKFTRAQDDILDDQ.IAD--ak..............................
F0ZF67_DICPU/157-291              .......knp----EQ.KRNRM.....FVG.L.L.N.R.TLQDFQK..N..I..SKK.............TE....SDL..RR....IEVDQKI......EKainKEEE.E....R.KE.N...E....R....IKK....EqLKE....K.EK....K.V....HE.ELI..KK.QE..EL...E....EK..I....L.K...E....SWS.LQNKVLSNFkY........K.....T..KCKPQI.........YFSLSPLADKIGFKLKIN.QDE--de..............................
G3T2M3_LOXAF/134-264              ..........MDEKGK.QRNRR.....IFG.L.L.M.G.TLQKFKQ..E..S..TVA.............TE....RQK..RR....QEIEQKL......EV...QAEE.E....R.KQ.V...E....N....ERR....E.LFE....E.RR....A.K....QT.ELR..LL.EQ..KV...E....LA..Q....L.Q...E....EWN.EHNAKIIKY.I........R.....T..KTKPHL.........FYIPGRMCPATQKLIEES.QRKMN................................
A9TTB0_PHYPA/157-234              .........s-DPNVA.KRNRR.....MFG.A.L.L.G.TLEKFRR..E..D..EKLs...........gSE....SFQ..RR....SEQLKKA......EH...KAQE.E....N.ER.L...R....Q....QEK....E.ALA....E.KR....R.A....DL.---..--.--..--...-....--..-....-.-...-....---.---------.-........-.....-..------.........------------------.-----vqsyl...........................
D8UC89_VOLCA/797-903              .........e-DPDSR.KRARR.....LLGrT.L.L.G.TLQRFRQ..E..D..AAFq...........aSD....AAA..RR....AELARKA......EE...KAAA.E....A.ER.L...R....R....QAA....E.ERA....R.K-....-.R....QE.ELD..--.--..--...-....--..-....-.-...-....---.---------.-........-.....-..------.........------------------.-----almdlnlatdikvlellyakklarrralaafl
#=GC seq_cons                     ...........spct+.pRN+R.....hFG.t.L.h.G.TLp+Fpp..E..p..p.h.............op....ppc..RR....pEIEp+h......-t...ptcp.E....c.cp.l...c....p....c++....p..ht....-.+R....t.c....ph.plR..th.-p..ch...t.....t..p....h.h...c....php.pp.tthtpa.l........+.....T..+scP.l.........aYhPhchs.tspphlppp..pp..................................
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