GenomeNet

Database: Pfam
Entry: Plasmod_Pvs28
LinkDB: Plasmod_Pvs28
Original site: Plasmod_Pvs28 
#=GF ID   Plasmod_Pvs28
#=GF AC   PF06247.9
#=GF DE   Pvs28 EGF domain
#=GF AU   Moxon SJ, Bateman A
#=GF SE   Pfam-B_11346 (release 9.0)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.00;
#=GF NC   25.90 25.90;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11738740
#=GF RT   Antibodies to Plasmodium vivax transmission-blocking vaccine
#=GF RT   candidate antigens Pvs25 and Pvs28 do not show synergism. 
#=GF RA   Hisaeda H, Collins WE, Saul A, Stowers AW; 
#=GF RL   Vaccine 2001;20:763-770.
#=GF RN   [2]
#=GF RM   16327807
#=GF RT   The essential mosquito-stage P25 and P28 proteins from
#=GF RT   Plasmodium form tile-like  triangular prisms.
#=GF RA   Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long
#=GF RA   CA, Garboczi DN;
#=GF RL   Nat Struct Mol Biol. 2006;13:90-91.
#=GF DR   INTERPRO; IPR010423;
#=GF CC   This family consists of several ookinete surface proteins
#=GF CC   (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are
#=GF CC   expressed on the surface of ookinetes. These proteins are
#=GF CC   potential candidates for vaccine and induce antibodies that
#=GF CC   block the infectivity of Plasmodium vivax in immunised animals
#=GF CC   [1]. The structure of this protein shows it is composed of four
#=GF CC   EGF domains [2].
#=GF SQ   77
#=GS A0A024VJK8_PLAFA/155-204  AC A0A024VJK8.1
#=GS B3L272_PLAKH/63-107       AC B3L272.1
#=GS Q7KJ23_PLAYO/154-214      AC Q7KJ23.1
#=GS A0A024WP66_PLAFA/156-193  AC A0A024WP66.1
#=GS Q4Z1V6_PLABA/156-193      AC Q4Z1V6.1
#=GS W7AAW5_PLAVN/156-193      AC W7AAW5.1
#=GS A0A024WP66_PLAFA/16-59    AC A0A024WP66.1
#=GS Q7KJ23_PLAYO/18-59        AC Q7KJ23.1
#=GS B3L271_PLAKH/18-59        AC B3L271.1
#=GS A0A024VJK8_PLAFA/111-149  AC A0A024VJK8.1
#=GS A5KDY7_PLAVS/20-59        AC A5KDY7.1
#=GS A0A024WFJ5_PLAFA/111-149  AC A0A024WFJ5.1
#=GS A0A024W6S6_PLAFA/111-149  AC A0A024W6S6.1
#=GS A0A024W6S6_PLAFA/155-204  AC A0A024W6S6.1
#=GS W7A3E2_9APIC/60-107       AC W7A3E2.1
#=GS Q4XXW2_PLACH/63-106       AC Q4XXW2.1
#=GS Q4XXW2_PLACH/21-59        AC Q4XXW2.1
#=GS Q7KQL2_PLAF7/109-150      AC Q7KQL2.1
#=GS A0A081IC85_PLAVN/156-193  AC A0A081IC85.1
#=GS Q8IJ96_PLAF7/155-204      AC Q8IJ96.1
#=GS A0A024W6S6_PLAFA/20-59    AC A0A024W6S6.1
#=GS A0A081IC85_PLAVN/21-59    AC A0A081IC85.1
#=GS Q8IJ96_PLAF7/111-149      AC Q8IJ96.1
#=GS K6UFE5_9APIC/155-202      AC K6UFE5.1
#=GS W7AY46_PLAVN/150-200      AC W7AY46.1
#=GS Q7RS43_PLAYO/22-59        AC Q7RS43.1
#=GS B3L272_PLAKH/110-152      AC B3L272.1
#=GS Q4Y9S0_PLABA/154-200      AC Q4Y9S0.1
#=GS W7AAW5_PLAVN/21-59        AC W7AAW5.1
#=GS A0A024VLF5_PLAFA/156-193  AC A0A024VLF5.1
#=GS W7AY46_PLAVN/18-59        AC W7AY46.1
#=GS A0A024WP66_PLAFA/63-106   AC A0A024WP66.1
#=GS K6UR63_9APIC/17-59        AC K6UR63.1
#=GS B3L272_PLAKH/158-195      AC B3L272.1
#=GS A0A024VLF5_PLAFA/109-150  AC A0A024VLF5.1
#=GS W7A3E2_9APIC/110-152      AC W7A3E2.1
#=GS A5KDY7_PLAVS/158-195      AC A5KDY7.1
#=GS A0A024VJK8_PLAFA/20-59    AC A0A024VJK8.1
#=GS W7ALG3_9APIC/155-217      AC W7ALG3.1
#=GS K6UCV7_9APIC/155-222      AC K6UCV7.1
#=GS Q7KQL2_PLAF7/63-106       AC Q7KQL2.1
#=GS Q4XXW2_PLACH/156-193      AC Q4XXW2.1
#=GS K6UFE5_9APIC/18-59        AC K6UFE5.1
#=GS Q7KJ23_PLAYO/111-148      AC Q7KJ23.1
#=GS A5KDY8_PLAVS/17-59        AC A5KDY8.1
#=GS K6UCV7_9APIC/18-59        AC K6UCV7.1
#=GS B3L272_PLAKH/20-59        AC B3L272.1
#=GS Q4Z1V6_PLABA/109-150      AC Q4Z1V6.1
#=GS B3L271_PLAKH/155-212      AC B3L271.1
#=GS Q7RS43_PLAYO/109-150      AC Q7RS43.1
#=GS Q4Y9S0_PLABA/63-108       AC Q4Y9S0.1
#=GS Q4XXW2_PLACH/109-150      AC Q4XXW2.1
#=GS A0A024VLF5_PLAFA/63-106   AC A0A024VLF5.1
#=GS A5KDY8_PLAVS/63-108       AC A5KDY8.1
#=GS A0A081IC84_PLAVN/151-202  AC A0A081IC84.1
#=GS W7ALG3_9APIC/18-59        AC W7ALG3.1
#=GS Q7KQL2_PLAF7/16-59        AC Q7KQL2.1
#=GS B3L271_PLAKH/111-149      AC B3L271.1
#=GS A0A024VLF5_PLAFA/16-59    AC A0A024VLF5.1
#=GS Q7RS43_PLAYO/156-193      AC Q7RS43.1
#=GS A5KDY7_PLAVS/63-107       AC A5KDY7.1
#=GS Q4Z1V6_PLABA/63-106       AC Q4Z1V6.1
#=GS A0A081IC84_PLAVN/18-59    AC A0A081IC84.1
#=GS W7A3E2_9APIC/158-195      AC W7A3E2.1
#=GS A0A024WFJ5_PLAFA/155-204  AC A0A024WFJ5.1
#=GS W7AAW5_PLAVN/109-150      AC W7AAW5.1
#=GS Q4Y9S0_PLABA/19-59        AC Q4Y9S0.1
#=GS A0A081IC85_PLAVN/109-150  AC A0A081IC85.1
#=GS A0A024WFJ5_PLAFA/20-59    AC A0A024WFJ5.1
#=GS A5KDY7_PLAVS/110-152      AC A5KDY7.1
#=GS Q4Z1V6_PLABA/23-59        AC Q4Z1V6.1
#=GS K6UTU6_9APIC/20-59        AC K6UTU6.1
#=GS Q8IJ96_PLAF7/20-59        AC Q8IJ96.1
#=GS A0A024WP66_PLAFA/109-150  AC A0A024WP66.1
#=GS Q7KQL2_PLAF7/156-193      AC Q7KQL2.1
#=GS W7A3E2_9APIC/21-59        AC W7A3E2.1
#=GS A5KDY8_PLAVS/155-222      AC A5KDY8.1
A0A024VJK8_PLAFA/155-204             .......PCSL.....K-CAENEVCTLE..---GNYYTCKEDpssngg..................gntvdqPDTSYSVINGVTL-t.......
B3L272_PLAKH/63-107                  .......ECKEen.lgKTCGDFGICRKGpdAAQQSTYKCDCI..............................KEYT---LKDGTCV........
Q7KJ23_PLAYO/154-214                 .......KCAL.....K-CKATEECKLV..---GTYYECISKnpapgtgsgtg.......sgtgsgtgsgtgTPANSSIMNGMSIF........
A0A024WP66_PLAFA/156-193             .......KCSL.....KCLKENETCKAV..---DGIYKCDCK..............................DGFI--IDNESSI-ct......
Q4Z1V6_PLABA/156-193                 .......PCSL.....VCGEEHQICKKV..---DDYYRCNCE..............................DGFKLS-IEENKCI........
W7AAW5_PLAVN/156-193                 .......KCSL.....VCGVEHQICKKI..---DAFYRCDCE..............................DGFKLS-VEEEKCI........
A0A024WP66_PLAFA/16-59               sikynna----.....K-VTVDTVCKRGflIQMSGHLECKCE..............................NDLV--LVNEETCE........
Q7KJ23_PLAYO/18-59                   ..rynna----.....K-VTVDTICTNGklIQMTSHLECKCI..............................PGYG--LKNENTCE........
B3L271_PLAKH/18-59                   ..kytfa----.....K-VTVDTQCKNGylIQKSNNFECKCN..............................DGFV--VTNENTCE........
A0A024VJK8_PLAFA/111-149             .......VCRD.....KVCG-KGKCIVD..PANSLTHTCSCN..............................IGTI--LNQNKLC-d.......
A5KDY7_PLAVS/20-59                   ...skaa----.....--VTVDTICKNGqlVQMSNHFKCMCN..............................EGLV--HLSENTCE........
A0A024WFJ5_PLAFA/111-149             .......VCRD.....KVCG-KGKCIVD..PANSLTHTCSCN..............................IGTI--LNQNKLC-d.......
A0A024W6S6_PLAFA/111-149             .......VCRD.....KVCG-KGKCIVD..PANSLTHTCSCN..............................IGTI--LNQNKLC-d.......
A0A024W6S6_PLAFA/155-204             .......PCSL.....K-CAENEVCTLE..---GNYYTCKEDpssngg..................gntvdqADTSYSVINGVTL-t.......
W7A3E2_9APIC/60-107                  ....eknECKEet.lgKACGDFGMCIKGpsPGQENTYKCGCI..............................EGYT---MKEGSCV........
Q4XXW2_PLACH/63-106                  .......ECSVnt.vdKACGEFSKCTKH.eNEGTETYTCDCI..............................NSYV---AKGNICV........
Q4XXW2_PLACH/21-59                   ...naai----.....---TPDTKCKNGflAQMSNHLECRCN..............................ENFV--HVSNDACE........
Q7KQL2_PLAF7/109-150                 .......ECKN.....VTCG-NGKCILD.tSNPVKTGVCSCN..............................IGKVPNVQDQNKC-s.......
A0A081IC85_PLAVN/156-193             .......KCSL.....VCGEEHQICKKI..---NDFYRCDCD..............................EGFKLN-VEEEKCV........
Q8IJ96_PLAF7/155-204                 .......PCSL.....K-CAENEVCTLE..---GNYYTCKEDpssngg..................gntvdqADTSYSVINGVTL-t.......
A0A024W6S6_PLAFA/20-59               ...nkar----.....--VTENTICKYGylIQMSNHYECKCI..............................EGYV--LINEDTC-g.......
A0A081IC85_PLAVN/21-59               ...naai----.....---TPNTKCKNGflAQMSNHLECRCN..............................ENFV--HVSNDTCE........
Q8IJ96_PLAF7/111-149                 .......VCRD.....KVCG-KGKCIVD..PANSLTHTCSCN..............................IGTI--LNQNKLC-d.......
K6UFE5_9APIC/155-202                 .......DCAL.....K-CKANEECKLT..---ENYYKCVAKgsggq....................gsggaTGAAYSLMNGSAVI........
W7AY46_PLAVN/150-200                 .......KCSL.....K-CKAQEECKLQ..---GKHYECVAKtqapgt.................gggagttPPTNGSFMNGMSIF........
Q7RS43_PLAYO/22-59                   ....aai----.....---TPATQCKNGflAQMSNHLECRCN..............................NNFV--HVSNDTCE........
B3L272_PLAKH/110-152                 .......VCLY.....KDCGQSGECIGE.fLTEVKSAACSCS..............................IGKVPNPEDEKKCT........
Q4Y9S0_PLABA/154-200                 .......KCLL.....K-CKAAEECKLT..---GKHYECVSKpqap.....................gtgseTPSNSSFMNGMSII........
W7AAW5_PLAVN/21-59                   ...naai----.....---TPDTKCKNGflAQMSNHLECRCN..............................ENFV--HVSNDTCE........
A0A024VLF5_PLAFA/156-193             .......KCSL.....KCLKENETCKAV..---DGIYKCDCK..............................DGFI--IDNESSI-ct......
W7AY46_PLAVN/18-59                   ..rysna----.....K-VTVDTICKNGklIQMSNHFECLCS..............................TGFV--LKSENTCE........
A0A024WP66_PLAFA/63-106              ......lKCDEkt.vnKPCGDFSKCIKI..DGNPVSYACKCN..............................LGYD---MVNNVCI........
K6UR63_9APIC/17-59                   .anytfa----.....K-VTADTQCKNGfvVQTGNYFECKCN..............................NGFV--LANENTCE........
B3L272_PLAKH/158-195                 .......TCQL.....KCNTENEVCKAV..---QGVYKCQCM..............................EGFKFD-KEKKECI........
A0A024VLF5_PLAFA/109-150             .......ECKN.....VTCG-NGKCILD.tSNPVKTGVCSCN..............................IGKVPNVQDQNKC-s.......
W7A3E2_9APIC/110-152                 .......VCQY.....KNCGESGECIPE.fMTEVQSAGCSCA..............................IGKVPNPEDEKKCT........
A5KDY7_PLAVS/158-195                 ......a-CQL.....KCNTDNEVCKNV..---EGVYKCQCM..............................EGFTFD-KEKNVC-l.......
A0A024VJK8_PLAFA/20-59               ...nkar----.....--VTENTICKYGylIQMSNHYECKCI..............................EGYV--LINEDTC-g.......
W7ALG3_9APIC/155-217                 ......q-CTL.....K-CKANEECLLT..---QNYYKCVAKesggegsggegs.....ggegsggegsggaTGAAYSLMNGYSVI........
K6UCV7_9APIC/155-222                 .......DCEL.....K-CKANEECKLT..---ENYYKCVAKgsggqgsggegsggegsggqgsggqgsggaTGAGYSLMNGSAVI........
Q7KQL2_PLAF7/63-106                  ......lKCDEkt.vnKPCGDFSKCIKI..DGNPVSYACKCN..............................LGYD---MVNNVCI........
Q4XXW2_PLACH/156-193                 .......PCSL.....VCSKEHQICKKV..---DAFYRCDCD..............................EGFKLS-IEEEKCI........
K6UFE5_9APIC/18-59                   ..nytfa----.....K-VTADTQCKNGyvVQMSNHFECKCN..............................NGFV--LANENTCE........
Q7KJ23_PLAYO/111-148                 .......KCFN.....YECP-SGKCILD..PNNPNNPTCSCD..............................IGKI---MQNGKCT........
A5KDY8_PLAVS/17-59                   .vkhtfa----.....K-VTAETQCKNGyvVQMSNHFECKCN..............................DGFV--LANENTCE........
K6UCV7_9APIC/18-59                   ..nytfa----.....K-VTADTQCKNGyvVQMSNHFECKCN..............................NGFV--LANENTCE........
B3L272_PLAKH/20-59                   ...skaa----.....--VTVDTLCKNGhlAQMSHHFKCICN..............................DGLV--HISENEC-g.......
Q4Z1V6_PLABA/109-150                 .......TCQN.....IDCG-YGKCIIN.eDSVNDPPICSCN..............................IGYVVNIDDGNKCT........
B3L271_PLAKH/155-212                 .......KCQL.....K-CKGNEQCKLT..---DNYYQCPSDgsggqgsgge..........gnggegsggsTGAAYSLMNGSAVI........
Q7RS43_PLAYO/109-150                 .......TCQN.....IDCG-NGKCIIN.eDAVNDPPTCSCN..............................IGYVVNVDDGSKCT........
Q4Y9S0_PLABA/63-108                  .......KCDKleninKVCGEYSICINQgnFGLEKAFVCMCT..............................NGYM---LSQNIC-k.......
Q4XXW2_PLACH/109-150                 .......TCQN.....IDCG-FGKCIIN.eDAVNDPPTCSCN..............................IGYVVNIDDGSKCT........
A0A024VLF5_PLAFA/63-106              ......lKCDEkt.vnKPCGDFSKCIKI..DGNPVSYACKCN..............................LGYD---MVNNVCI........
A5KDY8_PLAVS/63-108                  ......d-CTNpqnvnKNCGDYAVCANTrmNNEERALRCGCI..............................LGYT--VMN-EVC-t.......
A0A081IC84_PLAVN/151-202             .......KCTL.....K-CKAQEECKLK..---GKYYECVSKvpapgtg................ggagtttPPTSGSFMNGMSIF........
W7ALG3_9APIC/18-59                   ..kytfa----.....K-VTVDTQCKNGylVQMSNHFECRCN..............................DGFV--LANENTCE........
Q7KQL2_PLAF7/16-59                   sikynna----.....K-VTVDTVCKRGflIQMSGHLECKCE..............................NDLV--LVNEETCE........
B3L271_PLAKH/111-149                 ......r-CDG.....VICG-KGKCMLD..PDNSNSIICSCD..............................IGTV--LDDSKKCT........
A0A024VLF5_PLAFA/16-59               sikynna----.....K-VTVDTVCKRGflIQMSGHLECKCE..............................NDLV--LVNEETCE........
Q7RS43_PLAYO/156-193                 ......l-CSL.....VCNKEEQICKKV..---DSYYRCDCK..............................DGFKLS-VEEEKCI........
A5KDY7_PLAVS/63-107                  .......ECKKet.lgKACGEFGQCIENpdPAQVNMYKCGCI..............................EGYT---LKEDTCV........
Q4Z1V6_PLABA/63-106                  .......ECSKdt.vdKACGEFAKCTMH.eVGKEQTYTCDCA..............................KSYI---LKDDVCV........
A0A081IC84_PLAVN/18-59               ..rysna----.....K-VTVDTICKNGklIQMSNHYECLCS..............................PGFA--LKSENDCE........
W7A3E2_9APIC/158-195                 ......a-CQL.....KCNTENEVCRNV..---EGVYKCQCM..............................EGFTFD-KEKNVC-l.......
A0A024WFJ5_PLAFA/155-204             .......PCSL.....K-CAENEVCTLE..---GNYYTCKEDpssngg..................gntvdqADTSYSVINGVTL-t.......
W7AAW5_PLAVN/109-150                 .......TCQN.....IDCG-FGKCIVN.eDALNDPPICSCN..............................IGYVPNVDDGSKCT........
Q4Y9S0_PLABA/19-59                   ...ynna----.....K-ITVDTICKGGklIQMSNHYECKCP..............................SGYA--LKTENTCE........
A0A081IC85_PLAVN/109-150             .......TCQN.....IECG-FGKCIIN.eDAVNDPPICSCN..............................IGYVVNTEDGNKCT........
A0A024WFJ5_PLAFA/20-59               ...nkar----.....--VTENTICKYGylIQMSNHYECKCI..............................EGYV--LINEDTC-g.......
A5KDY7_PLAVS/110-152                 .......VCQY.....KNCGESGECIVE.yLSEIQSAGCSCA..............................IGKVPNPEDEKKCT........
Q4Z1V6_PLABA/23-59                   ....ais----.....----PNTQCKNGflAQMSNHLECRCN..............................EKFT--HVSNNTCK........
K6UTU6_9APIC/20-59                   ...skaa----.....--VTVDTVCKNGhlAQMSNHFKCICN..............................EGLV--HLSEDTCE........
Q8IJ96_PLAF7/20-59                   ...nkar----.....--VTENTICKYGylIQMSNHYECKCI..............................EGYV--LINEDTC-g.......
A0A024WP66_PLAFA/109-150             .......ECKN.....VTCG-NGKCILD.tSNPVKTGVCSCN..............................IGKVPNVQDQNKC-s.......
Q7KQL2_PLAF7/156-193                 .......KCSL.....KCLKENETCKAV..---DGIYKCDCK..............................DGFI--IDNESSI-ct......
W7A3E2_9APIC/21-59                   ....raa----.....--VTVDTICKNGhlGQMSNHFKCICN..............................EGLV--HVSENTCE........
A5KDY8_PLAVS/155-222                 .......ECTL.....K-CKANEECKET..---QNYYKCVAKgsggegsggegsggegsggegsggegsggdTGAAYSLMNGSAVI........
#=GC seq_cons                        ........Ct......K.ss.sshCphs...t.sstacCpCs..............................pGhs..hhspssC.........
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