GenomeNet

Database: Pfam
Entry: Pox_VP8_L4R
LinkDB: Pox_VP8_L4R
Original site: Pox_VP8_L4R 
#=GF ID   Pox_VP8_L4R
#=GF AC   PF04498.10
#=GF DE   Poxvirus nucleic acid binding protein VP8/L4R
#=GF AU   Kerrison ND
#=GF SE   DOMO:DM04340;
#=GF GA   25.00 25.00;
#=GF TC   27.60 287.40;
#=GF NC   21.80 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9321647
#=GF RT   Vaccinia virion protein VP8, the 25 kDa product of the L4R gene,
#=GF RT   binds single-stranded DNA and RNA with similar affinity. 
#=GF RA   Bayliss CD, Smith GL; 
#=GF RL   Nucleic Acids Res 1997;25:3984-3990.
#=GF DR   INTERPRO; IPR007586;
#=GF CC   The 25 kDa product of Vaccinia virus gene L4R is also known as
#=GF CC   VP8.  VP8 is found in the cores of Vaccinia virions and is
#=GF CC   essential for the formation of transcriptionally competent viral
#=GF CC   particles.  It binds both single stranded and double stranded
#=GF CC   DNA and RNA with similar affinities.  Binding is thought to
#=GF CC   involve cooperative interactions between protein subunits. The
#=GF CC   protein is proteolytically cleaved during viral assembly at an
#=GF CC   Ala-Gly-Ala site. Possible roles for VP8 include packaging and
#=GF CC   maintaining the DNA genome in a transcribable configuration;
#=GF CC   binding ssDNA during transcription initiation; and cooperation
#=GF CC   with I8R protein to unwind early promoter regions.  VP8 may also
#=GF CC   function in either transcription elongation or release of mRNA
#=GF CC   molecules from viral particles [1].
#=GF SQ   11
#=GS Q070F8_CPRVZ/31-240  AC Q070F8.1
#=GS Q6TUV0_YMTV5/33-249  AC Q6TUV0.1
#=GS VP8_VAR67/33-248     AC P33039.1
#=GS Q08FT0_DPV83/33-249  AC Q08FT0.1
#=GS Q9Q8N8_MYXVL/33-248  AC Q9Q8N8.1
#=GS Q9Q913_RFVKA/33-248  AC Q9Q913.1
#=GS Q6TVS0_ORFSA/32-249  AC Q6TVS0.1
#=GS VP8_FOWPN/32-252     AC P15913.1
#=GS Q8V3N4_SWPV1/34-250  AC Q8V3N4.1
#=GS Q98241_MCV1/31-250   AC Q98241.1
#=GS VP8_VACCW/33-248     AC P03295.1
Q070F8_CPRVZ/31-240             AKLRYPKSFLSIYRVVPRNTSKYRLRKLATETLVGFAMTTMESVRKSLNV--.TTATAQQVEEYFLD--NDVVTLAVGNTDVSKL..GSYKKRSRA.-KNPVVYRKSSAPVLLVFRSKNKMDVMIEDR.-EETTGTYARHEAG-AVVNTYLQTNFIDVYDPADQLTLDAVYGVpGSDLSLVKM-EGKALEKYQVTG.IQESITLSEFKELFSSAKKNIGVSNFI.
Q6TUV0_YMTV5/33-249             AKVRYPRSFLSIFNIIPRNMTKYELELVQTENITGAVFTTAFNIKKNLGMND.ENLTIEAIEGYYLDPNNDILTLMINNTSLMEV..-VPKRKSKR.NKNPVLFRQGSVPLFFIFESRKKVDIYKENIeNKKDSTSYSQIDENIALISKYSNMQLLDVHSPSAFMKLNGVYGF.THKNELRKLSSNKEIEEYSNKP.LQEPVRLNDFINLFDCVKKNIPLTNVI.
VP8_VAR67/33-248                AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD.DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV..-IPKKSGRRkNKNMVIFRQGSSPILCIFETRKKINIYKENM.-ESASTEYTPIGDNKALISKYAGINVLNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELELYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p
Q08FT0_DPV83/33-249             AKVKYPRSFLSIFNIIPRNMTKYELELVQTENITGAVFSTAFNIKKNLGITD.EKLTIEAIESYYLDPNNDVLTLMINNTSLDGV..-TPRKRSRR.NKNPVLFRQGSVPLFCIFDSRKKIGVYRENMnSPSKDNSYMQIEDNVALINKYANMSLLDVHSPSASMKLNAVYGF.THKNELRKLVSNKEIEEYSRKP.LQEPVRLNDFIGLFDSVKKNIPLTNI-p
Q9Q8N8_MYXVL/33-248             AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE.EKLTIEAIENYYLDPNNDVLTLMIDNTSLKEI..-SPRKKSRR.TKNPVLFRQGSIPLFFIFESRKKVDIYKENV.NKAVDGSYIKIDDNVALMGKYANMSLLDVHSPSAFMKLNAVYGF.THKNELRKLVSDKEIEEYSGQP.LQEPVRLNDFIGLFDGVKKSIPLTSI-p
Q9Q913_RFVKA/33-248             AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE.EKLTIEAIENYYLDPNNDVLTLMIDNTSLNEI..-SPRKKSKR.TKNPVLFRQGSIPLFFIFESRKKVDIYKENV.NKAVDGSYIKIDDNVALMGKYANMSLLDVHSPSAFMKLNAVYGF.THKNELRKLVSDKEIEEYSNHP.LQEPVRLNDFIGLFDGVKKSIPLTSI-p
Q6TVS0_ORFSA/32-249             ARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAVFTTAYNIRRNLGLGE.DPVTMRDIEKYFLDSDNEVLTLIVHNTDFSAM.sGVRRRGGRR.ITNPVIFRSGSTPLLIVMESRKKTNIYRERT.AEQANASYREVGSSLALVTRYAGLQLVDVHTPSSVLTVSAVYGF.TEDKGLKKLGSDKELADYQSTP.LTDPIRLSDFSKLFDGVKKSIQLTNV-p
VP8_FOWPN/32-252                ARSKFPKSLLSMYRVTPRVMTRYPLKLITNESITGVVITTVYNLKKNLNIPQnNKLTTQDIERYYLDKSVEVINLMVGNTSLGDLacGRPRRTKSSkKKDPVIFLGISAPLILVMNSKKSINTYIQDK.KSDPSSDYVNINPGIGVLENYGNTYLLDIHNPSSVLTISTIYGL.DNNMELKKLSTASEIDAYQDVN.IGKSVDLKKFNEIFNTMKKHLSLSNF-s
Q8V3N4_SWPV1/34-250             AKIKYPRSFLSIFNIIPRNMTRYSLDLIQTENITGAVFTTVFNIKKNLGMTD.ENLTIEAIENYYLDPNNDVITLMINNTSLDFI..-NPRKKSRR.NKNPVLFRQGSVPLFFIFDSRKKVEIYKENIdKMNENNTYTKINDNIALAGKYANLSLLDVHSPSASMKLNAVYGF.THKNELRKLSSDKEIEEYSKKP.LQEPVRLNDFIGLFDCVKKNIPLTNI-p
Q98241_MCV1/31-250              AKVKFPRSLLSMYRVVPRTMSRYELALVQSETVTGVVFTTVYNVRRNLGLEErEALSLPALEKYYLDKANDVLTLMVNNTNLEHI..AAYRMRSRR.LLNPVVFRAGAVPLALVFTSRKKLSIYREDTsQAAEDSTYTKIAANVALAGKYAGLLLLDVHTPGTALMLTAVYGL.DDRRELRKLADSTALENHQQSGaLSEAMKLSDFRAVFEGLKKSVPLTNL-e
VP8_VACCW/33-248                AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD.DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV..-IPKKSGRRkNKNMVIFRQGSSPILCIFETRKKINIYKENM.-ESASTEYTPIGDNKALISKYAGINILNVYSPSTSIRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p
#=GC seq_cons                   AKlKaPRShLSIFNIVPRsMT+YEL-LlpTENITGAVFTTsaNI+KNLGls-.-pLTIEAIEsYYLDPNNDVlTLMIsNTsLstl...sPRK+SRR.sKNPVlFRQGSsPLhhIF-SRKKlsIY+ENh.pcssssoYspIs-NlALluKYAshsLLDVHSPSush+LNAVYGF.TcKNEL+KLuosKElEcYSspP.LQEPlRLNDFluLF-sVKKsIPLTNl.P
//
DBGET integrated database retrieval system