GenomeNet

Database: Pfam
Entry: Proho_convert
LinkDB: Proho_convert
Original site: Proho_convert 
#=GF ID   Proho_convert
#=GF AC   PF12177.3
#=GF DE   Prohormone convertase enzyme
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_2ke3
#=GF GA   25.00 25.00;
#=GF TC   28.20 59.10;
#=GF NC   19.90 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19376969
#=GF RT   Functional and structural characterization of a dense core
#=GF RT   secretory granule sorting domain from the PC1/3 protease.
#=GF RA   Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P,
#=GF RA   Reudelhuber TL, Omichinski JG;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:7408-7413.
#=GF DR   INTERPRO; IPR022005;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   40 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF01483, Pfam:PF00082. There are two completely
#=GF CC   conserved residues (Y and D) that may be functionally important.
#=GF CC   This protein is the C terminal domain of a prohormone convertase
#=GF CC   enzyme which targets hormones in dense core secretory granules.
#=GF CC   This C terminal tail domain is the domain responsible for
#=GF CC   targeting these dense core secretory granules. The domain adopts
#=GF CC   an alpha helical structure. 
#=GF SQ   51
#=GS F1NB95_CHICK/704-744  AC F1NB95.1
#=GS O93583_PELRI/695-735  AC O93583.1
#=GS D2HUX9_AILME/712-752  AC D2HUX9.1
#=GS G1RV16_NOMLE/711-751  AC G1RV16.1
#=GS H3AFD1_LATCH/621-661  AC H3AFD1.1
#=GS G1P8D0_MYOLU/712-752  AC G1P8D0.1
#=GS F7B6Y5_CALJA/664-704  AC F7B6Y5.1
#=GS G1KMV9_ANOCA/706-746  AC G1KMV9.1
#=GS G3P2G0_GASAC/736-776  AC G3P2G0.1
#=GS H9FVB9_MACMU/708-748  AC H9FVB9.1
#=GS H2QR92_PANTR/712-752  AC H2QR92.1
#=GS NEC1_MUSCO/712-752    AC P63240.1
#=GS E6ZG11_DICLA/733-773  AC E6ZG11.1
#=GS G3SVS6_LOXAF/712-752  AC G3SVS6.1
#=GS Q4SD85_TETNG/788-828  AC Q4SD85.1
#=GS G3H754_CRIGR/586-626  AC G3H754.1
#=GS F6TCF0_HORSE/713-753  AC F6TCF0.1
#=GS G5BU25_HETGA/714-754  AC G5BU25.1
#=GS F7DCC0_MACMU/708-748  AC F7DCC0.1
#=GS F7GI61_MONDO/715-755  AC F7GI61.1
#=GS H2UMM7_TAKRU/714-754  AC H2UMM7.1
#=GS H0X116_OTOGA/713-753  AC H0X116.1
#=GS F1MFR6_BOVIN/712-752  AC F1MFR6.2
#=GS NEC1_HUMAN/712-752    AC P29120.2
#=GS NEC1_BOVIN/712-752    AC Q9GLR1.1
#=GS Q28959_PIG/712-752    AC Q28959.1
#=GS NEC1_RAT/711-751      AC P28840.1
#=GS G1T2Q3_RABIT/711-751  AC G1T2Q3.1
#=GS Q76FG1_LITCT/695-735  AC Q76FG1.1
#=GS H0VGG0_CAVPO/714-754  AC H0VGG0.1
#=GS H2UMM8_TAKRU/781-821  AC H2UMM8.1
#=GS H2PG51_PONAB/712-752  AC H2PG51.1
#=GS E2QX69_CANFA/712-752  AC E2QX69.1
#=GS G7P7Z4_MACFA/712-752  AC G7P7Z4.1
#=GS E9QIE6_DANRE/712-752  AC E9QIE6.1
#=GS B6VCA1_DANRE/713-753  AC B6VCA1.1
#=GS F6Z764_ORNAN/655-695  AC F6Z764.1
#=GS G3QVR2_GORGO/712-752  AC G3QVR2.1
#=GS B7Z8T7_HUMAN/665-705  AC B7Z8T7.1
#=GS Q59H85_HUMAN/683-723  AC Q59H85.1
#=GS F7EBE4_CALJA/711-751  AC F7EBE4.1
#=GS Q32MU0_MOUSE/712-752  AC Q32MU0.1
#=GS G7MVG7_MACMU/712-752  AC G7MVG7.1
#=GS NEC1_MOUSE/712-752    AC P63239.1
#=GS NEC1_MOUSE/712-752    DR PDB; 2KE3 A; 712-752;
#=GS NEC1_MOUSE/712-752    DR PDB; 2KDT A; 712-752;
#=GS G3VJH4_SARHA/711-751  AC G3VJH4.1
#=GS Q91065_LOPAM/733-773  AC Q91065.1
#=GS E9PHA1_HUMAN/665-705  AC E9PHA1.1
#=GS Q5R7S5_PONAB/712-752  AC Q5R7S5.1
#=GS H2LXE5_ORYLA/703-742  AC H2LXE5.1
#=GS H3CZ93_TETNG/700-740  AC H3CZ93.1
#=GS A1L3V6_HUMAN/712-752  AC A1L3V6.1
F1NB95_CHICK/704-744             ..QLKDSEESLYSDYVDLFYNAKPYKHRDDRLLQALVDIINE-g.
O93583_PELRI/695-735             ..GTKDRGNNLYNDYIDRFYNRRPYKHRDDRLLQALLNIVDKD..
D2HUX9_AILME/712-752             ..QLKDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALVDILREE..
G1RV16_NOMLE/711-751             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
H3AFD1_LATCH/621-661             ..QQKDSEDDLYNDYSDLFYNVKPYRHRDDRLLQALFELLKKE..
G1P8D0_MYOLU/712-752             .h-LKDTEDSLYNDYADVFYNTKPYKHRDDRLLQALVDILREE..
F7B6Y5_CALJA/664-704             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
G1KMV9_ANOCA/706-746             ..QLKDSEESLYNDYVDLFYNSKPYKHRDDRLLQALVDILNDE..
G3P2G0_GASAC/736-776             ..KYQGPEDSVYSDYSDGFYSIKPYRHRDDRLLQALFEMIDGD..
H9FVB9_MACMU/708-748             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
H2QR92_PANTR/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
NEC1_MUSCO/712-752               ..KLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEE..
E6ZG11_DICLA/733-773             ..KYRGTEDNVYSDYTDGFYSTKPYRHRDDRLLQALFEMIDD-g.
G3SVS6_LOXAF/712-752             ..QLRDPEDSVYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
Q4SD85_TETNG/788-828             ..KYGGPEDSVYSDYADGFYRTKPYRHRDDRLLQALFQMIGDE..
G3H754_CRIGR/586-626             ..QLKDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
F6TCF0_HORSE/713-753             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILREE..
G5BU25_HETGA/714-754             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
F7DCC0_MACMU/708-748             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
F7GI61_MONDO/715-755             ..QLKNDENSLYSDYVDLFYNTKPYKHRDDRLLQALVDILKE-g.
H2UMM7_TAKRU/714-754             ..KYGGPEDNVYSDYADGFYRTKPYRHRDDRLLQALFQMIGDE..
H0X116_OTOGA/713-753             ..QLKDSDDSLYHDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
F1MFR6_BOVIN/712-752             ..QLKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLREE..
NEC1_HUMAN/712-752               ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
NEC1_BOVIN/712-752               ..QLKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLREE..
Q28959_PIG/712-752               ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILREE..
NEC1_RAT/711-751                 ..QLEDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNE-k.
G1T2Q3_RABIT/711-751             ..QLQDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNED..
Q76FG1_LITCT/695-735             .g-AKDKGNNLYNDYIDRFYNRRPYKHRDDRLLQALLNIVDKD..
H0VGG0_CAVPO/714-754             ..QLKDSEDTLYHDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
H2UMM8_TAKRU/781-821             ..KYGGPEDNVYSDYADGFYRTKPYRHRDDRLLQALFQMIGDE..
H2PG51_PONAB/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
E2QX69_CANFA/712-752             ..QLKDSEDNLYSDYVDVFYNTKPYKHRDDRLLQALVDILREE..
G7P7Z4_MACFA/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
E9QIE6_DANRE/712-752             .r-YRASQNGLFNDYSDNFYRAQPYRHRDDRLLQALFDMLRDD..
B6VCA1_DANRE/713-753             .r-YRASQNGLFNDYSDNFYRAQPYRHRDDRLLQALFDMLRDD..
F6Z764_ORNAN/655-695             pi--RDSEDSLYGDDVDVFYNTKPYKHRDDLLRQALLNILN--gr
G3QVR2_GORGO/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
B7Z8T7_HUMAN/665-705             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
Q59H85_HUMAN/683-723             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
F7EBE4_CALJA/711-751             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
Q32MU0_MOUSE/712-752             ..KLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEE..
G7MVG7_MACMU/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
NEC1_MOUSE/712-752               ..KLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEE..
#=GR NEC1_MOUSE/712-752    SS    ..-SSSS-SSSSHHHHHCCCT---SS-SCHHHHHHHHHHCCC-..
G3VJH4_SARHA/711-751             ..QLRNAENSLYSDYVDLFYSTKPYKHRDDRLLQALVDILKE-g.
Q91065_LOPAM/733-773             ..KYQGPEDSVYSDYTDGFYSAKPYKHRDDRLLQALFEMIGDD..
E9PHA1_HUMAN/665-705             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
Q5R7S5_PONAB/712-752             ..QLKDSEDSLYDDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
H2LXE5_ORYLA/703-742             ..KYHGAGDNIYSDYSDGFYNIKPYRHRDDRLMQALFQMLDD-..
H3CZ93_TETNG/700-740             ..KYGGPEDSVYSDYADGFYRTKPYRHRDDRLLQALFQMIGDE..
A1L3V6_HUMAN/712-752             ..QLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEE..
#=GC SS_cons                     ..-SSSS-SSSSHHHHHCCCT---SS-SCHHHHHHHHHHCCC-..
#=GC seq_cons                    ..QLKDSEDSLYsDYVDVFYNTKPYKHRDDRLLQALVDILsEE..
//
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