GenomeNet

Database: Pfam
Entry: Proho_convert
LinkDB: Proho_convert
Original site: Proho_convert 
#=GF ID   Proho_convert
#=GF AC   PF12177.6
#=GF DE   Prohormone convertase enzyme
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_2ke3
#=GF GA   25.00 25.00;
#=GF TC   26.80 34.50;
#=GF NC   22.80 17.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19376969
#=GF RT   Functional and structural characterization of a dense core
#=GF RT   secretory granule sorting domain from the PC1/3 protease.
#=GF RA   Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P,
#=GF RA   Reudelhuber TL, Omichinski JG;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:7408-7413.
#=GF DR   INTERPRO; IPR022005;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   40 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF01483, Pfam:PF00082. There are two completely
#=GF CC   conserved residues (Y and D) that may be functionally important.
#=GF CC   This protein is the C terminal domain of a prohormone convertase
#=GF CC   enzyme which targets hormones in dense core secretory granules.
#=GF CC   This C terminal tail domain is the domain responsible for
#=GF CC   targeting these dense core secretory granules. The domain adopts
#=GF CC   an alpha helical structure. 
#=GF SQ   59
#=GS H2UMM7_TAKRU/715-753      AC H2UMM7.1
#=GS G3P2G0_GASAC/737-775      AC G3P2G0.1
#=GS A0A093BA31_CHAPE/646-684  AC A0A093BA31.1
#=GS W5LZN5_LEPOC/703-733      AC W5LZN5.1
#=GS H0X116_OTOGA/714-752      AC H0X116.1
#=GS G7P7Z4_MACFA/713-751      AC G7P7Z4.1
#=GS M3ZTQ7_XIPMA/733-771      AC M3ZTQ7.1
#=GS F6TCF0_HORSE/714-752      AC F6TCF0.1
#=GS F1MFR6_BOVIN/713-751      AC F1MFR6.2
#=GS G3H754_CRIGR/587-625      AC G3H754.1
#=GS H2UMM8_TAKRU/782-820      AC H2UMM8.1
#=GS F7B6Y5_CALJA/665-703      AC F7B6Y5.1
#=GS G3VJH4_SARHA/712-750      AC G3VJH4.1
#=GS E9QIE6_DANRE/713-751      AC E9QIE6.1
#=GS G3SVS6_LOXAF/713-751      AC G3SVS6.1
#=GS V8P1Y2_OPHHA/696-734      AC V8P1Y2.1
#=GS G1KMV9_ANOCA/868-906      AC G1KMV9.2
#=GS G5BU25_HETGA/715-753      AC G5BU25.1
#=GS U3JJX3_FICAL/709-747      AC U3JJX3.1
#=GS H2QR92_PANTR/713-751      AC H2QR92.1
#=GS A0A0G2JX54_RAT/588-626    AC A0A0G2JX54.1
#=GS G1RV16_NOMLE/712-750      AC G1RV16.1
#=GS F7DCC0_MACMU/709-747      AC F7DCC0.1
#=GS F7GI61_MONDO/716-754      AC F7GI61.1
#=GS E2QX69_CANLF/713-751      AC E2QX69.1
#=GS G1T2Q3_RABIT/712-750      AC G1T2Q3.1
#=GS NEC1_MOUSE/713-751        AC P63239.1
#=GS NEC1_MOUSE/713-751        DR PDB; 2KE3 A; 713-751;
#=GS NEC1_MOUSE/713-751        DR PDB; 2KDT A; 713-751;
#=GS G3QVR2_GORGO/713-751      AC G3QVR2.1
#=GS W5Q845_SHEEP/713-751      AC W5Q845.1
#=GS S9WAG8_9CETA/113-151      AC S9WAG8.1
#=GS A0A087XXH9_POEFO/737-766  AC A0A087XXH9.2
#=GS H2LXE5_ORYLA/704-742      AC H2LXE5.1
#=GS M3XZ36_MUSPF/713-751      AC M3XZ36.1
#=GS NEC1_HUMAN/713-751        AC P29120.2
#=GS I3KX34_ORENI/728-766      AC I3KX34.1
#=GS F6Z764_ORNAN/588-626      AC F6Z764.2
#=GS W5KGZ8_ASTMX/713-751      AC W5KGZ8.1
#=GS G1P8D0_MYOLU/713-751      AC G1P8D0.1
#=GS A0A0D9RPD1_CHLSB/709-747  AC A0A0D9RPD1.1
#=GS NEC1_RAT/712-750          AC P28840.1
#=GS H2PG51_PONAB/713-751      AC H2PG51.1
#=GS M3W5Q0_FELCA/713-751      AC M3W5Q0.1
#=GS F7EBE4_CALJA/712-750      AC F7EBE4.1
#=GS L5KJL9_PTEAL/706-744      AC L5KJL9.1
#=GS R0K3G2_ANAPL/652-690      AC R0K3G2.1
#=GS M7BZ79_CHEMY/664-702      AC M7BZ79.1
#=GS B6VCA1_DANRE/714-752      AC B6VCA1.1
#=GS A0A096MPL7_PAPAN/709-747  AC A0A096MPL7.1
#=GS A0A0N8JYZ4_9TELE/725-763  AC A0A0N8JYZ4.1
#=GS A0A091DTA5_FUKDA/714-752  AC A0A091DTA5.1
#=GS NEC1_BOVIN/713-751        AC Q9GLR1.1
#=GS D2HUX9_AILME/713-751      AC D2HUX9.1
#=GS F1RNV5_PIG/713-751        AC F1RNV5.2
#=GS H0VGG0_CAVPO/715-753      AC H0VGG0.1
#=GS Q32MU0_MOUSE/713-751      AC Q32MU0.1
#=GS F1NB95_CHICK/708-746      AC F1NB95.2
#=GS A0A096LWJ8_POEFO/721-759  AC A0A096LWJ8.1
#=GS H3AFD1_LATCH/622-660      AC H3AFD1.1
#=GS H3CZ93_TETNG/701-739      AC H3CZ93.1
H2UMM7_TAKRU/715-753                 ........YGGPEDNVYSDYADGFYRTKPYRHRDDRLLQALFQMIGD.
G3P2G0_GASAC/737-775                 ........YQGPEDSVYSDYSDGFYSIKPYRHRDDRLLQALFEMIDG.
A0A093BA31_CHAPE/646-684             ........LRDSEESLYSDYVDLFYNAKPYKHRDDRLLQALVDIVS-e
W5LZN5_LEPOC/703-733                 gqysqpsa----------------YSATPYRHRDGRLLQAFVDMLTE.
H0X116_OTOGA/714-752                 ........LKDSDDSLYHDYVDVFYNTKPYKHRDDRLLQALVDILNE.
G7P7Z4_MACFA/713-751                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
M3ZTQ7_XIPMA/733-771                 ........FSGPGDSLYSDYSDGFYNIKPYKHRNDRLLQALFEMLDD.
F6TCF0_HORSE/714-752                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILRE.
F1MFR6_BOVIN/713-751                 ........LKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLRE.
G3H754_CRIGR/587-625                 ........LKDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALVDILNE.
H2UMM8_TAKRU/782-820                 ........YGGPEDNVYSDYADGFYRTKPYRHRDDRLLQALFQMIGD.
F7B6Y5_CALJA/665-703                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
G3VJH4_SARHA/712-750                 ........LRNAENSLYSDYVDLFYSTKPYKHRDDRLLQALVDILKE.
E9QIE6_DANRE/713-751                 ........YRASQNGLFNDYSDNFYRAQPYRHRDDRLLQALFDMLRD.
G3SVS6_LOXAF/713-751                 ........LRDPEDSVYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
V8P1Y2_OPHHA/696-734                 ........LRDSEESLYSDYVDLFYNSKSYKHRDDRLLQALVDILNE.
G1KMV9_ANOCA/868-906                 ........LKDSEESLYNDYVDLFYNSKPYKHRDDRLLQALVDILND.
G5BU25_HETGA/715-753                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
U3JJX3_FICAL/709-747                 ........LRGSEESLYSDYVDLFYNAKPYKHRDDRLLQALVDIINE.
H2QR92_PANTR/713-751                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
A0A0G2JX54_RAT/588-626               .......l-EDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNE.
G1RV16_NOMLE/712-750                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
F7DCC0_MACMU/709-747                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
F7GI61_MONDO/716-754                 .......l-KNDENSLYSDYVDLFYNTKPYKHRDDRLLQALVDILKE.
E2QX69_CANLF/713-751                 ........LKDSEDNLYSDYVDVFYNTKPYKHRDDRLLQALVDILRE.
G1T2Q3_RABIT/712-750                 .......l-QDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
NEC1_MOUSE/713-751                   .......l-EGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNE.
#=GR NEC1_MOUSE/713-751        SS    .......S-SSS-SSSSHHHHHCCCT---SS-SCHHHHHHHHHHCCC.
G3QVR2_GORGO/713-751                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
W5Q845_SHEEP/713-751                 ........LKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLRE.
S9WAG8_9CETA/113-151                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILRE.
A0A087XXH9_POEFO/737-766             ........FSGPGDSLYSDYSDSFYSIKPYKHRNDRLL---------.
H2LXE5_ORYLA/704-742                 ........YHGAGDNIYSDYSDGFYNIKPYRHRDDRLMQALFQMLDD.
M3XZ36_MUSPF/713-751                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILRE.
NEC1_HUMAN/713-751                   ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
I3KX34_ORENI/728-766                 ........YRSPEDSVYSDYSDGFYSTKPYRHRDDRLLQALFEMLDD.
F6Z764_ORNAN/588-626                 .......i-RDSEDSLYGDDVDVFYNTKPYKHRDDLLRQALLNILNG.
W5KGZ8_ASTMX/713-751                 .......h-RNPESSLYNHYRDSFYRNRAYRHRDEQLLQALFDMLDG.
G1P8D0_MYOLU/713-751                 .......l-KDTEDSLYNDYADVFYNTKPYKHRDDRLLQALVDILRE.
A0A0D9RPD1_CHLSB/709-747             ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
NEC1_RAT/712-750                     .......l-EDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNE.
H2PG51_PONAB/713-751                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
M3W5Q0_FELCA/713-751                 .......l-KESEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILRE.
F7EBE4_CALJA/712-750                 ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
L5KJL9_PTEAL/706-744                 .......l-KEAEDSLYNNYLDGFYNTKPYKHRDDRLLQALMDILRE.
R0K3G2_ANAPL/652-690                 ........LKDSEESLYSDYVDLFYNAKPYKHRDDRLLQALVDIINE.
M7BZ79_CHEMY/664-702                 ........LKDSEDTLYSDYIDLFYNAKPYKHRDDRLLQALVDILNE.
B6VCA1_DANRE/714-752                 ........YRASQNGLFNDYSDNFYRAQPYRHRDDRLLQALFDMLRD.
A0A096MPL7_PAPAN/709-747             ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNE.
A0A0N8JYZ4_9TELE/725-763             ........YRGSEENLYSDYSDVFYNAKPYKHRDDRLLQALFDMITE.
A0A091DTA5_FUKDA/714-752             ........LKDSEDSLYNNYVDVFYNTKSYKHRDDRLLQALVDILNE.
NEC1_BOVIN/713-751                   ........LKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLRE.
D2HUX9_AILME/713-751                 ........LKDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALVDILRE.
F1RNV5_PIG/713-751                   ........LKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILRE.
H0VGG0_CAVPO/715-753                 ........LKDSEDTLYHDYVDVFYNTKPYKHRDDRLLQALVDILNE.
Q32MU0_MOUSE/713-751                 .......l-EGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNE.
F1NB95_CHICK/708-746                 ........LKDSEESLYSDYVDLFYNAKPYKHRDDRLLQALVDIINE.
A0A096LWJ8_POEFO/721-759             ........FSGPGDSLYSDYSDSFYSIKPYKHRNDRLLQALFEMLDD.
H3AFD1_LATCH/622-660                 .......q-KDSEDDLYNDYSDLFYNVKPYRHRDDRLLQALFELLKK.
H3CZ93_TETNG/701-739                 ........YGGPEDSVYSDYADGFYRTKPYRHRDDRLLQALFQMIGD.
#=GC SS_cons                         .......S-SSS-SSSSHHHHHCCCT---SS-SCHHHHHHHHHHCCC.
#=GC seq_cons                        ........h+DSEDSLYsDYVDlFYNTKPYKHRDDRLLQALVDILsE.
//
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