GenomeNet

Database: Pfam
Entry: RESP18
LinkDB: RESP18
Original site: RESP18 
#=GF ID   RESP18
#=GF AC   PF14948.1
#=GF DE   RESP18 domain
#=GF AU   Eberhardt R
#=GF SE   Jackhmmer:Q5W5W9
#=GF GA   25.00 25.00;
#=GF TC   25.40 27.50;
#=GF NC   21.50 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21104147
#=GF RT   Requirement of regulated endocrine-specific protein-18 for
#=GF RT   development and expression of regulated endocrine-specific
#=GF RT   protein-18 isoform c in mice.
#=GF RA   Liang M, Yang JL, Bian MJ, Liu J, Hong XQ, Wang YC, Huang YF, Gu
#=GF RA   SP, Yu M, Huang F, Fei J;
#=GF RL   Mol Biol Rep. 2011;38:2557-2562.
#=GF RN   [2]
#=GF RM   17951542
#=GF RT   RESP18, a homolog of the luminal domain IA-2, is found in dense
#=GF RT   core vesicles in  pancreatic islet cells and is induced by high
#=GF RT   glucose.
#=GF RA   Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR,
#=GF RA   Swaim WD, Leapman RD, Notkins AL;
#=GF RL   J Endocrinol. 2007;195:313-321.
#=GF CC   This domain is found in the glucocorticoid-responsive protein
#=GF CC   regulated endocrine-specific protein 18 (RESP18) and in the
#=GF CC   N-terminal extracellular region of receptor-type
#=GF CC   tyrosine-protein phosphatases containing the protein-tyrosine
#=GF CC   phosphatase receptor IA-2 domain (Pfam:PF11548) [1,2].
#=GF SQ   113
#=GS H3DG99_TETNG/22-119  AC H3DG99.1
#=GS G3NIN0_GASAC/50-148  AC G3NIN0.1
#=GS F6UK71_MONDO/63-163  AC F6UK71.1
#=GS A8K604_HUMAN/60-160  AC A8K604.1
#=GS H9FXU6_MACMU/59-155  AC H9FXU6.1
#=GS PTPRN_HUMAN/60-160   AC Q16849.1
#=GS G3HTT8_CRIGR/2-89    AC G3HTT8.1
#=GS A3KPJ3_DANRE/70-158  AC A3KPJ3.1
#=GS RES18_MOUSE/37-140   AC P47939.1
#=GS G3SFN6_GORGO/74-173  AC G3SFN6.1
#=GS F7A9S9_XENTR/49-151  AC F7A9S9.1
#=GS PTPRN_BOVIN/60-160   AC P56722.1
#=GS F7H047_MACMU/60-158  AC F7H047.1
#=GS F7ES81_MACMU/37-137  AC F7ES81.1
#=GS RES18_RAT/37-140     AC P47940.1
#=GS D2HQQ8_AILME/22-122  AC D2HQQ8.1
#=GS G5AKJ5_HETGA/37-139  AC G5AKJ5.1
#=GS H0Z6G4_TAEGU/22-104  AC H0Z6G4.1
#=GS F1QIB8_DANRE/50-149  AC F1QIB8.1
#=GS E2RPN6_CANFA/37-143  AC E2RPN6.1
#=GS B4DK12_HUMAN/1-70    AC B4DK12.1
#=GS G7N8Z9_MACMU/37-137  AC G7N8Z9.1
#=GS H0VV96_CAVPO/19-117  AC H0VV96.1
#=GS B2GU79_XENTR/49-157  AC B2GU79.1
#=GS Q9Y4I9_HUMAN/59-170  AC Q9Y4I9.1
#=GS E9Q8T8_MOUSE/37-146  AC E9Q8T8.1
#=GS F1PB22_CANFA/5-76    AC F1PB22.1
#=GS B0CM60_PAPAN/60-160  AC B0CM60.1
#=GS F6U2N5_CALJA/65-170  AC F6U2N5.1
#=GS G1RDV0_NOMLE/50-150  AC G1RDV0.1
#=GS C9JCQ0_HUMAN/1-70    AC C9JCQ0.1
#=GS A6MDD2_MOUSE/63-163  AC A6MDD2.1
#=GS F1PMD6_CANFA/60-160  AC F1PMD6.1
#=GS F6TGE3_CALJA/72-172  AC F6TGE3.1
#=GS E7FF61_DANRE/47-144  AC E7FF61.1
#=GS F1R8X1_DANRE/47-146  AC F1R8X1.1
#=GS G5AKJ6_HETGA/60-160  AC G5AKJ6.1
#=GS Q4RQS0_TETNG/18-119  AC Q4RQS0.1
#=GS F5H035_HUMAN/60-159  AC F5H035.1
#=GS Q925J6_MOUSE/1-58    AC Q925J6.1
#=GS H2P8P2_PONAB/60-160  AC H2P8P2.1
#=GS G3INC6_CRIGR/1-70    AC G3INC6.1
#=GS Q9Y4I6_HUMAN/42-153  AC Q9Y4I6.1
#=GS H2R644_PANTR/60-160  AC H2R644.1
#=GS F6US37_HORSE/37-139  AC F6US37.1
#=GS F1SR78_PIG/69-169    AC F1SR78.1
#=GS PTPR2_RAT/58-145     AC Q63475.1
#=GS D2HQQ9_AILME/2-100   AC D2HQQ9.1
#=GS H0XDK2_OTOGA/37-140  AC H0XDK2.1
#=GS E9PC57_HUMAN/42-153  AC E9PC57.1
#=GS F7E5U0_CALJA/60-160  AC F7E5U0.1
#=GS RES18_BOVIN/37-139   AC A0JNL8.1
#=GS B4DGA1_HUMAN/60-159  AC B4DGA1.1
#=GS F1SR77_PIG/37-139    AC F1SR77.1
#=GS G3WJ01_SARHA/22-113  AC G3WJ01.1
#=GS E9QB40_DANRE/47-144  AC E9QB40.1
#=GS F5GZS3_HUMAN/1-70    AC F5GZS3.1
#=GS Q6GPA6_XENLA/49-157  AC Q6GPA6.1
#=GS B3DJH4_DANRE/47-146  AC B3DJH4.1
#=GS G7PK47_MACFA/37-137  AC G7PK47.1
#=GS E6ZJ13_DICLA/4-93    AC E6ZJ13.1
#=GS F7D9P9_HORSE/64-164  AC F7D9P9.1
#=GS G3T308_LOXAF/60-160  AC G3T308.1
#=GS G7PK46_MACFA/25-125  AC G7PK46.1
#=GS Q5DTQ3_MOUSE/76-176  AC Q5DTQ3.1
#=GS G5C8S2_HETGA/42-133  AC G5C8S2.1
#=GS PTPRN_MOUSE/63-163   AC Q60673.2
#=GS C9JJL7_HUMAN/1-70    AC C9JJL7.1
#=GS G1KP25_ANOCA/22-116  AC G1KP25.1
#=GS B9W0B0_MOUSE/37-120  AC B9W0B0.1
#=GS G3I619_CRIGR/12-114  AC G3I619.1
#=GS RES18_HUMAN/37-138   AC Q5W5W9.1
#=GS H2P8P3_PONAB/37-136  AC H2P8P3.1
#=GS F6R0M5_CALJA/60-159  AC F6R0M5.1
#=GS G3R874_GORGO/73-173  AC G3R874.1
#=GS H0V3J5_CAVPO/60-159  AC H0V3J5.1
#=GS F6PIZ6_CALJA/60-160  AC F6PIZ6.1
#=GS F6TF72_CALJA/33-132  AC F6TF72.1
#=GS B3DJG5_DANRE/47-146  AC B3DJG5.1
#=GS G7N8Z8_MACMU/60-160  AC G7N8Z8.1
#=GS G1U816_RABIT/60-160  AC G1U816.1
#=GS PTPR2_HUMAN/59-170   AC Q92932.2
#=GS G1MEF3_AILME/37-140  AC G1MEF3.1
#=GS A8MW94_HUMAN/1-56    AC A8MW94.1
#=GS H2QJG8_PANTR/79-169  AC H2QJG8.1
#=GS PTPR2_MACNE/57-150   AC O02695.1
#=GS Q8BT93_MOUSE/37-139  AC Q8BT93.1
#=GS G1T8W0_RABIT/37-139  AC G1T8W0.1
#=GS H0XDJ7_OTOGA/60-160  AC H0XDJ7.1
#=GS H9FXU7_MACMU/59-155  AC H9FXU7.1
#=GS H2PP66_PONAB/21-134  AC H2PP66.1
#=GS F6RCL7_MONDO/60-160  AC F6RCL7.1
#=GS B0KWI8_CALJA/1-70    AC B0KWI8.1
#=GS F7ES91_MACMU/37-141  AC F7ES91.1
#=GS H2UFW5_TAKRU/27-105  AC H2UFW5.1
#=GS Q5R982_PONAB/60-160  AC Q5R982.1
#=GS Q59FU1_HUMAN/32-132  AC Q59FU1.1
#=GS G3NSZ9_GASAC/22-121  AC G3NSZ9.1
#=GS F6UK62_MONDO/57-157  AC F6UK62.1
#=GS C9JR27_HUMAN/27-127  AC C9JR27.1
#=GS H9EW26_MACMU/60-160  AC H9EW26.1
#=GS Q925J7_MOUSE/1-58    AC Q925J7.1
#=GS Q6NVE2_MOUSE/67-167  AC Q6NVE2.1
#=GS PTPRN_RAT/66-166     AC Q63259.2
#=GS C9J392_HUMAN/1-66    AC C9J392.1
#=GS F7GFM0_CALJA/67-166  AC F7GFM0.1
#=GS H2UFW6_TAKRU/27-105  AC H2UFW6.1
#=GS F7GWZ3_CALJA/1-70    AC F7GWZ3.1
#=GS G1MEE8_AILME/60-160  AC G1MEE8.1
#=GS C0HAC4_SALSA/47-139  AC C0HAC4.1
#=GS H2UFW4_TAKRU/27-105  AC H2UFW4.1
#=GS G3QNU1_GORGO/79-178  AC G3QNU1.1
#=GS G1PAU4_MYOLU/66-163  AC G1PAU4.1
H3DG99_TETNG/22-119             .............GQCL-SSKQDKVQYQVSVPVLKRMQE.VLKQLM...LQG...LSWQD.DITQYILSKELKRVPH..TsR..A..SKP.....SSSSPSSHSPQDL----------------...--------------ckfgrssskipsssvlsgpnstr.....................................
G3NIN0_GASAC/50-148             .............GKCQELAAADLYTYDISSSGFAAPQGsFLQKLA...HRG...LTWQD.DITQQVISKELSKLRTipL.R..H..QAS.....APSPLTAHSSSRD----------------...--------------rklsrnlqqylaglgllsqse.......................................
F6UK71_MONDO/63-163             .............GQCQTGAGRVRPLLQVTSPILQRLQG.VLRQLM...SQG...LSWQD.DLTQYVISQEMERIPR..L.R..P..PDP.....GSKDRSSLAARRP----ALPGELLPPDPP...TGSAPAAQH-----rlprp.......................................................
A8K604_HUMAN/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
H9FXU6_MACMU/59-155             grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RHP.....EA---------------------------...--------------sgparpskhsigserrysreggaalakafrrhl...........................
PTPRN_HUMAN/60-160              .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G3HTT8_CRIGR/2-89               ........dtyry--------------EVSPGALLHLRV.TLQKLS...RTG...FTWQD.DYTQHVMAQELANLPK..A.Y..P..W--.....---HGDTSSPARTLQQNADNEK---WFSP...--------------eseaalaktlrryl..............................................
A3KPJ3_DANRE/70-158             .............GQCLRYPGSDVSSFDVSPAAVQRLRS.VLQKLA...HRG...YTWQD.DITQQVISKELSQLPR..V.-..-..---.....-----------------------------...--------------slggfantfphfndnsrklkaqkeaasrtlqr............................
RES18_MOUSE/37-140              .............GQGQVGSEQLWTFQGLIASVFQYLQL.IFHQIV...PEG...MFWAD.DIAYELMTKKVEHLSR..L.H..P..QYP.....CRKDMKAVSPTANAGVRSKQEEKLQLLSP...-QKSPTVKVNRDRC............................................................
G3SFN6_GORGO/74-173             .............GQDQVGVGQLWPLQGFATPVFQHLQV.VLQQII...PQG...LFWKD.DITQDAMIQKMEHASR..L.H..P..QDP.....CLKDGKALFPTKTTES-------------...--------------plakvnrdqcftskvvskalkq......................................
F7A9S9_XENTR/49-151             .............GQCRPRADRDDAPFQVPPGALQQLQG.VLRQLT...AKG...FPWKD.DMTPRLLAHEMGRIPQ..H.R..P..LET.....LDGLDE-DRSGRTMQRLPGMSQ---MSAPr.wAGSADKLQYFRPR-l...........................................................
PTPRN_BOVIN/60-160              .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRRP----GPAGELLLQGIP...TGSAPALQHR----lprp........................................................
F7H047_MACMU/60-158             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...KVWRDwNLVSYGLSMPFPRLQH..I.H..F..---.....AFLYRSGLAPRRP----GPAGELLLQDIP...TGSAPASQ------hrlpqp......................................................
F7ES81_MACMU/37-137             .............GQDQVGVEQLWPLQGFATPVFQHLQV.VFQQIL...PQG...LFWKD.DITQDAMIQKMEHTSR..L.H..P..QDP.....CLKDGKAVFPTKTAGS-------------...--------------plakvnrdqcftskvvskvlkqe.....................................
RES18_RAT/37-140                .............GQGQVGSEQLWTFQGLVASVFQYLQL.LFHHIV...PQG...MFWTD.DIAYELMTKKVEHLSR..L.H..P..QYP.....CRKEGKVVSPIATTGVRGKQEEKLRLLSP...-QKSPAVKVNRDRC............................................................
D2HQQ8_AILME/22-122             .............GQCQVGAGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.H..P..PEP.....RPRDRSGLVPRRP----GPAGELLLQGIP...TGSTPATQHR----lpqp........................................................
G5AKJ5_HETGA/37-139             .............GQCQAEVAQLWPLQEFTAPFFRHLQV.LLHQLV...PQG...LFWKN.DIIQDLMTQNMEHMSR..L.H..L..QDP.....CLKGGKAIFPARTTGVRGKQEEKLQLLFP...--TSPMPRVNRDQC............................................................
H0Z6G4_TAEGU/22-104             .............GQCQVGSVQDRPYFQVTSPVLQRLQD.VLRHLM...AQG...LSWQD.GITQYVISQEMERIPR..L.RlpP.sLEP.....VARDR------------------------...--------------dlplypgelpqrs...............................................
F1QIB8_DANRE/50-149             .............GQCLRYPGSDVSSFDVSPAAVQRLRS.VLQKLA...HRG...YTWQD.DITQQVISKELSQLPR..V.-..-..---.....-----------------------------...--------------slggfantfphfndnsrklkaqkeaasrtlqrflqgflpsdvs.................
E2RPN6_CANFA/37-143             .............GQGQVGVGQFWSLPGFATPVFQHLQA.VFQEIV...PQA...LFWKD.DITQDVMAQKIEQIGR..F.H..P..QDP.....CLRHGQAAFPTKTTEVMSKQEEKLRLLLPk.nSSQSPMTKVNREQC............................................................
B4DK12_HUMAN/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G7N8Z9_MACMU/37-137             .............GQDQVGVGQLWPLQGFATPVFQHLQV.VFQQIL...PQG...LFWKD.DITQDAMIQKMEHTSR..L.H..P..QDP.....CLKDGKAVFPTKTAGS-------------...--------------plakvnrdqcftskvvskvlkqe.....................................
H0VV96_CAVPO/19-117             .............GQGQADSGQLWPLKGFAAPFFHHLQV.LLHQLI...SHG...LFWKD.DIVQHLMTQNMEHMSR..L.Y..A..HDP.....YLKGRKSVLPTKISQS-------------...--------------pvpkvnrdqcfsskvnakvlk.......................................
B2GU79_XENTR/49-157             .............GQCRPRADRDDAPFQVPPGALQQLQG.VLRQLT...AKG...FPWKD.DMTPRLLAHEMGRIPQ..H.R..P..LETldgldEDRSPLSLGSGRTMQRLPGMSQ---MSAPr.wAGSADKLQYFRPR-l...........................................................
Q9Y4I9_HUMAN/59-170             grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RRPeasspARPSKHSVGSERRYSREG-----------...--------------gaalanalrrhlpflealsqapasdvl.................................
E9Q8T8_MOUSE/37-146             .............GQGQVGSEQLWTFQGLIASVFQYLQL.IFHQIV...PEG...MFWAD.DIAYELMTKG------..-.-..-..---.....-----------------------------...--------------gapqqtpppvsmqegyegsfphgkrwgeeqargetstlispkesnsqgeqgpmlyhqsnp
F1PB22_CANFA/5-76               ............g-RCQKVPALDTDQYEVPPVVLQRLTA.TLQRLS...HTG...FKWQD.DYTQNMMAQELSDLPQ..T.Y..P..RH-.....-----------------------------...--------------ldtpstasvlq.................................................
B0CM60_PAPAN/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPASQH-----rlpqp.......................................................
F6U2N5_CALJA/65-170             .............GQDQSRNGQLWPS-KIAIPVFQHLQ-.VLQQII...PRG...LFWKD.DITQDVMTQKMEHVSR..L.H..P..QDP.....CLKDGKAVFPTKTTGSL------------...--------------laklnrdrcftskviskalkqevsnptts...............................
G1RDV0_NOMLE/50-150             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
C9JCQ0_HUMAN/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
A6MDD2_MOUSE/63-163             .............GQCQAGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
F1PMD6_CANFA/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLVPRRP----GPAGELLLQGLP...TGSTPAAQHR----lpqp........................................................
F6TGE3_CALJA/72-172             .............GQDQSRNGQLWPSKDC-HPSLPAFTS.VLQQII...PRG...LFWKD.DITQDVMTQKMEHVSR..L.H..P..QDP.....CLKDGKAVFPTKTTGSL------------...--------------laklnrdrcftskviskalkqev.....................................
E7FF61_DANRE/47-144             .grceaapltnvy------------TYDVTPATVQRLRN.LLQRLA...HRG...LSWED.DVTQQILSNEFSKLRR..V.S..LplPEP.....RPKGYEIAFGDRRMKSSSDAEVK------...--------------ntlkylqhlll.................................................
F1R8X1_DANRE/47-146             .............GQCRS-SRHDQVQYQVSVPVLQRLQQ.VLKELM...LQG...FSWQD.EITQQIIAKELSRIPH..T.R..T..QKS.....QNAQP------------------------...--------------pppaakkvysspnsepgpaqsyvdymvldphqss..........................
G5AKJ6_HETGA/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQA.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PET.....RQRDRSGLMPRRP----VPAGELLLQGIP...TGSAPAAQGL----prpp........................................................
Q4RQS0_TETNG/18-119             .............GQCL-SSKQDKVQYQVSVPVLKRMQE.VLKQLM...LQG...LSWQD.DITQYILSKELKRVPH..TsR..A..SKP.....SSSSPSSHSPQSQANQRERERD-------...--------------rqllqealslylasaqps..........................................
F5H035_HUMAN/60-159             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQLL----svp.........................................................
Q925J6_MOUSE/1-58               .............--------------------------.------...---...-----.---QHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
H2P8P2_PONAB/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G3INC6_CRIGR/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQHVISQEMERIPR..L.R..P..PEP.....HPRDRSSLVPRRP----GPAGELLSQGNP...TGSSPAAQGL----prps........................................................
Q9Y4I6_HUMAN/42-153             grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RRPeasspARPSKHSVGSERRYTRE------------...--------------ggaalanalrrhlpfledlsqapasdvl................................
H2R644_PANTR/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....HPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
F6US37_HORSE/37-139             .............GQGQVGVGQLWPLQGFATPVFQNLQV.VLQQIV...PQG...LFWKD.GMTQDAMTQKMEHISR..P.H..P..QDP.....CLRDGQAAFPTRSTGVRGKQEEKLRLLFP...--KSPVAKVTRDQC............................................................
F1SR78_PIG/69-169               .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....PARDRSGLVPRRP----GPAGELLLQGIP...TGSAPAPQH-----rlprp.......................................................
PTPR2_RAT/58-145                ......grcqkvp-------ALDTYRYEVSPGALLHLRI.ILQKLS...RTG...FTWQD.DYTQRVIAQELSNLPK..A.Y..-..---.....-LWHEEASSPARS----------------...--------------lqqnadnekwfsleseva..........................................
D2HQQ9_AILME/2-100              .............GQGQVGAEQLWTLQGFATPVFQHMQV.VLQQIV...PQG...LFWKD.GITQDVMAQK--HISR..F.H..P..QDP.....CLRHGQAAFPTKTTGIS------------...--------------pvakvnseqcftskvylktlkr......................................
H0XDK2_OTOGA/37-140             .............GQDQVGVGQFWSLQGLTTPVFQNLQV.ILQQIV...PQG...LFWKN.DITQDIFPQ-ME---H..F.N..P..QNP.....CLRDEKAAFPTKLTRGKGKQKEKIRLLFPklpSSQSPVAKVNKDQC............................................................
E9PC57_HUMAN/42-153             grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RRPeasspARPSKHSVGSERRYSREG-----------...--------------gaalanalrrhlpflealsqapasdvl.................................
F7E5U0_CALJA/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..L..PEP.....RPRDRSGLAPRRP----GPTGELLLQDIP...TGSAPAAQHR----lpqp........................................................
RES18_BOVIN/37-139              .............GQSQVGVGQLWPLPGFTTPVFKHLQV.LLQQIM...PHD...LFWKD.DMTQEVMTQKMGRTSK..L.H..P..EDP.....CVRSGPAAFPTRTPGVRGKQEEKLRLLFP...--KSPMVKVNKDQC............................................................
B4DGA1_HUMAN/60-159             .............GQCQVGVGQAWPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQLL----svp.........................................................
F1SR77_PIG/37-139               .............GQGQVGVGQLWPLQGFTTPIFQHLQV.VLQQIV...PQG...LFWKD.DMTQNVMTQKMGHISQ..L.H..P..QDP.....CVRVGQAASPTKTTGARGKQEEKLRLLFP...--KSPVVKVNRDQC............................................................
G3WJ01_SARHA/22-113             .............GQCQTGAGRVRPLLQVTSPILQRLQS.VLRQLM...SQGnhvIIWVD.CLLILLLASPIFILPK..H.Q..D..QEP.....KNCVTGKTLENMN----------------...--------------cevradhtggrker..............................................
E9QB40_DANRE/47-144             .grceaapltnvy------------TYDVTPATVQRLRN.LLQRLA...HRG...LSWED.DVTQQILSNEFSKLRR..V.S..LplPEP.....RPKGYEIAFGDRRMKSSSDAEVK------...--------------ntlkylqhlll.................................................
F5GZS3_HUMAN/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
Q6GPA6_XENLA/49-157             .............GQCRPRAERDDPPYQMATGTLQQLQG.VLQQLT...AKG...FSWKD.DMTPRLMAHKMGRISQ..H.R..P..LEPldgldEDRFPLSHASGRTMQRLSGASQ---PSTPr.wASSSDKLQYFRPR-l...........................................................
B3DJH4_DANRE/47-146             .............GQCLRYPGSDVSSFDVSPAAVQRLRS.VLQKLA...HRG...YTWQD.DITQQVISKELSQLPR..V.-..-..---.....-----------------------------...--------------slggfantfphfndnsrklkaqkeaasrtlqrflqgflpsdvs.................
G7PK47_MACFA/37-137             .............GQDQVGVGQLWPLQGFATPVFQHLQV.VFQQIL...PQG...LFWKD.DITQDAMIQKMEHTSR..L.H..P..QDP.....CLKDGKAVFPTKTAGS-------------...--------------plakvnrdqcftskvvskvlkqe.....................................
E6ZJ13_DICLA/4-93               .............GRCQELAGANLYTYDISSLALQRLRI.LLQKLA...HRG...LTWQD.DITQQVISRELSKLRN..V.-..P..LR-.....HQAAPPSLSSSRDRKLRPAQA--------...--------------elnrnlqqy...................................................
F7D9P9_HORSE/64-164             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..TEP.....HPRDRSGLVPRRP----GPTGELLLQGIP...TGSAPVAQH-----rlprp.......................................................
G3T308_LOXAF/60-160             .............GQCQVGVGQVRPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RLRDRSGLVPRRP----GPTGELLSQGIP...TGSAPAAQHL----lprs........................................................
G7PK46_MACFA/25-125             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPASQH-----rlpqp.......................................................
Q5DTQ3_MOUSE/76-176             .............GQCQAGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
G5C8S2_HETGA/42-133             .............GRCQKVPGLDISRYEVSPVALQHLRA.TLQALS...RTG...FMWQE.DDTQRIMAQELAGLLR..A.H..P..QHM.....ETSS-PARVSQQN----------------...--------------vdterqyslendvalakt..........................................
PTPRN_MOUSE/63-163              .............GQCQAGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
C9JJL7_HUMAN/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G1KP25_ANOCA/22-116             .............GQCQESSQQDRPYFQVSAAVLQRLQD.VLRHLM...AQG...LSWQD.GLTQYVISREMERIPK..L.H..L..STT.....WESVAENSSP-------------------...--------------dspksphtdtqtlcaklpsmypa.....................................
B9W0B0_MOUSE/37-120             .............GQGQVGSEQLWTFQGLIASVFQYLQL.IFHQIV...PEG...MFWAD.DIAYELMTKKVEHLSR..L.H..P..QYP.....CRKDMKAVSPTANAGVRVQQS--------...--------------r...........................................................
G3I619_CRIGR/12-114             .............GQGHVTSEPLWPFQGFAASIFRYLKY.VLHQIV...PED...LFWTD.ELAQEVLTKKVEHLSR..L.H..L..HNP.....CRKEGKAVSTTATTGVRGKQEEKHGFLYP...--KNPAVKVSKDRC............................................................
RES18_HUMAN/37-138              .............GQDQVGVGQLWPLQGFATPVFQHLQV.VLQQII...PQG...LFWKD.DITQDAMIQKMEHASR..L.H..P..QEP.....CLKDGKALFPTKT----TEQEEKLQLLFP..sETHSPLAKVNRDQC............................................................
H2P8P3_PONAB/37-136             .............GQDQVGVGQLWPLQGFATPVFQHLQV.VLQQII...PQG...LFWKD.DITQDAMIQKMEHASR..L.H..P..QDP.....CLKDGKAVFPTKTTES-------------...--------------plakvnrdqcftskvvskvlkq......................................
F6R0M5_CALJA/60-159             .............GQCQVGVGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..L..PEP.....RPRDRSGLAPRRP----GPTGELLLQDIP...TGSAPAAQLL----svp.........................................................
G3R874_GORGO/73-173             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAEELLLQDIP...TGSAPAAQHR----lpqp........................................................
H0V3J5_CAVPO/60-159             .............GQCQVGVGQARPLLQVTSPVLQRLQA.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEL.....RPRDRSGLMLRRP----VPTGELFLQGIP...TGSAQAAQ------glprp.......................................................
F6PIZ6_CALJA/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..L..PEP.....RPRDRSGLAPRRP----GPTGELLLQDIP...TGSAPAAQHR----lpqp........................................................
F6TF72_CALJA/33-132             .............GQDQVGMGNFGPP-RIAIPVFQHLQ-.VLQQII...PRG...LFWKD.DITQDVMTQKMEHVSR..L.H..P..QDP.....CLKDGKAVFPTKT----TGQGERLQLLFP..gETHSLLAKLNRDRC............................................................
B3DJG5_DANRE/47-146             .............GQCRS-SRHDQVQYQVSVPVLQRLQQ.VLKELM...LQG...FSWQD.EITQQIIAKELSRIPH..T.R..T..QKS.....QNAQP------------------------...--------------pppaakkvysspnsepgpaqsyvdymvldphqss..........................
G7N8Z8_MACMU/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPASQH-----rlpqp.......................................................
G1U816_RABIT/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGVVPRQP----GPAGELLSQGIP...TGSAPAAQL-----glprp.......................................................
PTPR2_HUMAN/59-170              grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RRPeasspARPSKHSVGSERRYSREG-----------...--------------gaalanalrrhlpflealsqapasdvl.................................
G1MEF3_AILME/37-140             .............GQGQVGAEQLWTLQGFATPVFQHMQV.VLQQIV...PQG...LFWKD.GITQDVMAQK--HISR..F.H..P..QDP.....CLRHGQAAFPTKTTGIRGKQKEKLRLLFP..kPSQSPVAKVNSEQC............................................................
A8MW94_HUMAN/1-56               .............--------------------------.------...---...-----.------MIQKMEHASR..L.H..P..QEP.....CLKDGKALFPTKT----TEQEEKLQLLFP..sETHSPLAKVNRDQC............................................................
H2QJG8_PANTR/79-169             .............GQDQVGVGQLWTLQGFATPVFQHLQV.VLQQII...PQG...LFWKD.DITQDAMIQKMEHASR..L.H..P..QDP.....CLKDGKALFPTKTTES-------------...--------------plakvnrdqcfts...............................................
PTPR2_MACNE/57-150              grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RHP.....EA---------------------------...--------------sgparpskhsigserrysqeggaalakafr..............................
Q8BT93_MOUSE/37-139             .............GQGQVGSEQLWTFQGLIASVFQYLQL.IFHQIV...PEG...MFWAD.DIAYELMTKG------..-.-..-..---.....-----------------------------...--------------gapqqtpppvsmqegyegsfphgkrwgeeqargetstlispkesnsqgeqgpm.......
G1T8W0_RABIT/37-139             .............GQGQVGAGQLWSLQGFTTPVFWHLQV.VLQQIV...PQG...LFWKD.DITQDVMTQKMEHISR..L.H..P..QDP.....CMKDGKAVFPTKTSGVRGKKEDKLRLLFP...--KSPVAKMNKEQC............................................................
H0XDJ7_OTOGA/60-160             .............GQCQVGMGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.H..P..PES.....RSRDRSGLAPRRP----GPAGQLLLQGIP...TGSVPAAQQ-----rlprp.......................................................
H9FXU7_MACMU/59-155             grcqkvpamdfyr-------------YEVSPVALQRLRV.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RHP.....EA---------------------------...--------------sgparpskhsigserrysreggaalakafrrhl...........................
H2PP66_PONAB/21-134             grcqkvpamdfyr-------------YEVSPVALQRLRL.ALQKLS...GTG...FTWQD.DYTQYVMDQELADLPK..T.Y..L..RRPeasspARPSKHSVGSERKYSREGGA---------...--------------alakalrhhlpflealsqapasdvlar.................................
F6RCL7_MONDO/60-160             .............GQCQTGAGRVRPLLQVTSPILQRLQG.VLRQLM...SQG...LSWQD.DLTQYVISQEMERIPR..L.R..P..PDP.....GSKDRSSLAARRP----ALPGELLPPDPP...TGSAPAAQH-----rlprp.......................................................
B0KWI8_CALJA/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..L..PEP.....RPRDRSGLAPRRP----GPTGELLLQDIP...TGSAPAAQHR----lpqp........................................................
F7ES91_MACMU/37-141             .............GQDQVGVEQLWPLQGFATPVFQHLQV.VFQQIL...PQG...LFWKD.DITQDAMIQKMEHTSR..L.H..P..QDP.....CLKDGKAVFPTKTAGKQARGET-LTPI-Ph.sESHSPLAKVNRDQC............................................................
H2UFW5_TAKRU/27-105             .............GQCL-SSKQDKVQYQVSVQVLKRMQE.VLKQLM...LQG...LSWQD.DITQYILSKELKRVPH..TsR..T..SKS.....SSSFPSSHSP-------------------...--------------qlvflks.....................................................
Q5R982_PONAB/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
Q59FU1_HUMAN/32-132             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G3NSZ9_GASAC/22-121             .............GQCRT-SKQDLVQYQVTVPVLKRMQE.VLKQLMlgaRTG...LSWQN.DITQYILSKELKRVPH.tT.H..P..SRP.....NPSSSSSHSSQSVPS--------------...--------------syrdphhhlftagpglsslp........................................
F6UK62_MONDO/57-157             .............GQCQTGAGRVRPLLQVTSPILQRLQG.VLRQLM...SQG...LSWQD.DLTQYVISQEMERIPR..L.R..P..PDP.....GSKDRSSLAARRP----ALPGELLPPDPP...TGSAPAAQH-----rlprp.......................................................
C9JR27_HUMAN/27-127             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQHR----lpqp........................................................
H9EW26_MACMU/60-160             .............GQCQVGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPRRP----GPAGELLLQDIP...TGSAPASQH-----rlpqp.......................................................
Q925J7_MOUSE/1-58               .............--------------------------.------...---...-----.---QHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
Q6NVE2_MOUSE/67-167             .............GQCQAGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQHVISQEMERIPR..L.R..P..PEP.....HPRDRSGLLPRKP----GPAGELLTQGNP...TGSSPAAQGFP---rpa.........................................................
PTPRN_RAT/66-166                .............GQCQAGVGQARPLLQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....HPRDRSGSVPRRA----GPAGELLSQGNP...TGSSPAVQGLSR--pp..........................................................
C9J392_HUMAN/1-66               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....RPRDRSGLAPKRP----GPAGELLLQDIP...TGSAPAAQ------hr..........................................................
F7GFM0_CALJA/67-166             .............GQDQVGMGNFGPP-RIAIPVFQHLQ-.VLQQII...PRG...LFWKD.DITQDVMTQKMEHVSR..L.H..P..QDP.....CLKDGKAVFPTKTTESL------------...--------------laklnrdrcftskviskalkqev.....................................
H2UFW6_TAKRU/27-105             .............GQCL-SSKQDKVQYQVSVQVLKRMQE.VLKQLM...LQG...LSWQD.DITQYILSKELKRVPH..TsR..T..SKS.....SSSFPSSHSP-------------------...--------------qlvflks.....................................................
F7GWZ3_CALJA/1-70               .............--------------------------.-----M...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..L..PEP.....RPRDRSGLAPRRP----GPTGELLLQDIP...TGSAPAAQHR----lpqp........................................................
G1MEE8_AILME/60-160             .............GQCQVGAGQARPLLQVTSPVLQRLQS.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.H..P..PEP.....RPRDRSGLVPRRP----GPAGELLLQGIP...TGSTPATQHR----lpqp........................................................
C0HAC4_SALSA/47-139             .......gqcllp-------QQERVLYEVSVPVLHRLQE.VLKELM...MQG...LSWQD.DITQYVIRKELSRVSL..T.R..P..SSG.....RHDNPSSQSSEP-----------------...--------------vqnahlskmqyppssrtkaq........................................
H2UFW4_TAKRU/27-105             .............GQCL-SSKQDKVQYQVSVQVLKRMQE.VLKQLM...LQG...LSWQD.DITQYILSKELKRVPH..TsR..T..SKS.....SSSFPSSHSP-------------------...--------------qlvflks.....................................................
G3QNU1_GORGO/79-178             .............GQDQVGVGQLWPLQGFATPVFQHLQV.VLQQII...PQG...LFWKD.DITQDAMIQKMEHASR..L.H..P..QDP.....CLKDGKALFPTKTTES-------------...--------------plakvnrdqcftskvvskalkq......................................
G1PAU4_MYOLU/66-163             .............GQCQVGVGQARPLFQVTSPVLQRLQG.VLRQLM...SQG...LSWHD.DLTQYVISQEMERIPR..L.R..P..PEP.....HPRDRSGLVPRRP----GPAEELLLQGIP...TGPAPA--------aphrl.......................................................
#=GC seq_cons                   .............GQsQsussQhhshhpVosPVLQ+LQs.VLpQLh...sQG...LoW+D.DlTQaVloQEME+lPR..L.+..P...-P.....ps+DtpulsPp+s....s.ttp......P.............................................................................
//
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