GenomeNet

Database: Pfam
Entry: RE_HaeII
LinkDB: RE_HaeII
Original site: RE_HaeII 
#=GF ID   RE_HaeII
#=GF AC   PF09554.9
#=GF DE   HaeII restriction endonuclease
#=GF AU   Coggill P
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   91.90 91.60;
#=GF NC   24.30 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11852561
#=GF RT   [Testing and isolation of high-purity restriction
#=GF RT   endonucleases]. 
#=GF RA   Puchkova LI, Ushakova TA, Mikhailova VK, Serov GD, Krivopalova
#=GF RA   GN, Repin VE; 
#=GF RL   Prikl Biokhim Mikrobiol. 2002;38:20-24.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019058;
#=GF CC   This family includes the HaeII (recognises and cleaves RGCGC^Y)
#=GF CC   restriction endonuclease.
#=GF SQ   18
#=GS A0A0F5YJ57_9CYAN/1-173  AC A0A0F5YJ57.1
#=GS K9SQV9_9SYNE/7-342      AC K9SQV9.1
#=GS A0A0G1ZDU2_9BACT/8-343  AC A0A0G1ZDU2.1
#=GS R6DEP8_9BACE/7-342      AC R6DEP8.1
#=GS E6KAK0_9BACT/7-342      AC E6KAK0.1
#=GS A0A0J9EYL5_9CYAN/8-181  AC A0A0J9EYL5.1
#=GS K9UB28_9CYAN/6-342      AC K9UB28.1
#=GS Q5F5D7_NEIG1/8-343      AC Q5F5D7.1
#=GS A7BSW8_9GAMM/8-347      AC A7BSW8.1
#=GS W4PB60_9BACE/6-343      AC W4PB60.1
#=GS A0A132GSM1_9BACT/8-344  AC A0A132GSM1.1
#=GS A0A0A2FJY0_9PORP/6-343  AC A0A0A2FJY0.1
#=GS B1WXK7_CYAA5/1-260      AC B1WXK7.1
#=GS I3CC74_9GAMM/7-344      AC I3CC74.1
#=GS A0A0G1LHA2_9BACT/7-342  AC A0A0G1LHA2.1
#=GS A0YZ87_LYNSP/342-679    AC A0YZ87.1
#=GS V8C922_9HELI/13-346     AC V8C922.1
#=GS F0F9N4_9BACT/3-86       AC F0F9N4.1
A0A0F5YJ57_9CYAN/1-173             .-----------------------------------..-----------------------------------------------------------------------------------..-----------------------------------------------LNVTVKVELDINKLDILQEFEDFTQKVLSINSQ.NPSFTANAKFYRVGVTNAADRGLDMWANYGPAIQIKHLSLNESLAEGIVSHITADRIVIVCRDSEEKTIISLLNQIGWKSRIQSIITQSHLEAWYEKALRGSFRHILGAKLIQVLIEEIKYEFPS.SESNDLVSFMENRGY...........
K9SQV9_9SYNE/7-342                 .AKERLDSIVRKARVDMYKPIQIAEVLRRSRIQKDI..QILKQDTYQNPSIHWRNKVTRRLIGKVSTSSANYQHDIWNQKAMPPDLLAVLDHENKRTNGGVEYYIYLRFSERQNTVASVIT..FIETSLPENFDLSELLIKFTSQSEIRRSVDKAYEIVVYSLFETIVNALETTVKVSIPVKNTNLLAEFSDLTKVLLGLELG.SNSWEVPAHIYRVGVTNAADRGLDMWANFGAAIQVKHLTLNQERAQSITNQVESDNVVIVCRDADARVIETIANQISWGSRVRGIVKESELIDWYERCLRGKFSKQLSKALLERLVYGFKSEFPQ.--ASTISDFLSERNY...........
A0A0G1ZDU2_9BACT/8-343             s-KKALDLVIRKSRVHLYKPIQIAEILYHHRTERGL..DLSDLQSYRNISKRWRDEVSLLLVGRRSTSSQKYQDNVFEANAMPPELLTKLGEINKKSKGVVEAYIYKALEARLSSVREVED..YIRKSTPDTFDLKKLVSIFQTTPGLRRSVDKMYEILVYALFTTIVRALKAQVTLEIGNKDKEILKDFERFIKMVLGIDAK.QTRLVSPAALYRVGVTNASDRGLDIWANFGPAIQVKHLTLTPELMEDIADDITSDRIVIVCIDTERETIETLLKQVGWSERIQGVITINDLDDWYKLCLSKKYRANLGAKLLQDVGREFAAEFPS.--SKEIAPFMAKRGY...........
R6DEP8_9BACE/7-342                 .AKAALDNVIKKSRVHLYKPIQVAEILYRDRVFKDI..NLLSLEDYRTKSKKWRDEVSIVLLGRVSTSSARFQDDLFNDNATPPAVLDVLGRENRRTNGAVEAYIYSKFDNKHEQLSNALA..YCLDASVETFEVKKFIDSFWNEPGLKRSLDKIYEIIVYALFSTLVEAMNLEVEVTVKEDAYPLLKEFEDFTQKVMCLDCS.TPQHIQEARVYRVGVTNAADRGLDMYSNWGPAIQIKHLSLDISLAESIVNSVSSDRIVIVCKDAEKDVIVSLLSQIGWRSHIQSIVTENDLIKWYEKALRGSYSEQLGEKLLYCLASEIAEEFPS.VD-------------ytpeiikkrhy
E6KAK0_9BACT/7-342                 .AKAALDTVIKKSRVHLYKPIQIAEILYRDRIYKDI..NLLSLEDYRTKSKKWRDKVSIVLLGRVSTSSARFQDDLFNDNATPPAVLDVLGHENRRTNGAVEAYIYNKFDYKHEQLSNALS..YCLDADTESFEVKKFIDSFWNEPGLKRSLDKIYEIIVYALFSTLVDAMNLKVEVTVGEEAYPLLKEFEEFTKKIMCLDCS.TPQHIQEAKVYRVGVTNAADRGLDMYSNWGPAIQIKHLSLDLTIAENIVNSVSSDRIVIVCKDAEKDVIVSLLTQIGWRSHIQSIVTENDLVTWYEKALRGSYSDMLGEKLLFCLANEIAEEFPS.VD--STPEIIKERH-y..........
A0A0J9EYL5_9CYAN/8-181             .AKNALDNIINKARVHFYKPIQVAEILYHHRVFDDL..TLADINTYRTASKRWRDVICKRFLGRITNSSSRYQDNLFEQNATPPEVLMLLGEENKNKSGIVEAYIYRKFIERYSQMTSGLA..YCMKSDIENFELTEFIGQFQNNPGLKRSIDKIYEIVVYALFKVLIEELNVTVKVE-------------------------.-----------------------------------------------------------------------------------------------------------------------------.---------------l..........
K9UB28_9CYAN/6-342                 .AKAALDRIIKISRVHLYKPIQIAEILYRDRVHRDL..DLSDLNTYRNTSKAWRNLITDRFVGRSSSSSAEYQEALFTK-AMPPQTLVILGEENRLKGGIIEAYIYRRFAERFTQLSSALN..YYDTHSTTDFEVREFIDLFWSEPGLRRSIDKVYEIVVYSLFSVLVEALEVTITISINESKLGLLEEFSDFTEMVIGLTQD.KYLLNLPAKIYRVGVTNAADRGLDMYANFGMAIQIKHLSLTPELAENIVGSVTADRIVIVCRDSEQALIVSLLNQIGWKAKIQSIITENNLQGWYEKALRGSFSAAIGKRILLTLKEQIIAEFPA.SDNRDFTEFYESRNY...........
Q5F5D7_NEIG1/8-343                 .AKEALDGIIKKSRVHLYKPIQIAEILYHDRCIKQL..DFLNLDTYRNQSKRWRDEICRRFLGRISTSSAKFQDNLFEKNAIPPEKLAVLGTLNRQSDGGVESYIYKQFFNRFSQMSEALA..YVGNTDRYSFQLSEFLNLFWLEPGLKRSIDKIYEIVVYALFDALVSELGITVSIDFPKENLFLWEEYQDFAEKIITMPKN.EH-LKLPAKIHRVGVTNAADRGLDMWSNFGLAIQVKHLSLDEELAEDIVSSISADRIVIVCKKAEQSVIVSLLTQIGWKSRIQNIVTEDDLISWYEKALRGQYP--IAEALLENIKTEIMREFPAvNEANEFLDFAQNRGY...........
A7BSW8_9GAMM/8-347                 .AKNALDSIIKKSRVHLYKPIQIAEILYNARTQPDLeiELSNLESYRTRSKQWRDVVCIQFLGRVSTSSAKFQDNLFEENAMPPHLLSILGVENQKNNGIVEAYIYQAFEDKHLQLDNALN..YCLTSTKENFKLGEFLNQFWSEAGLKRSLDKIFEMVVYSLFEVLTTSIHVKIDIYYNTNNTDILNEFSEFSDKVLNLTAS.TNRKTLDAHFHRVGVTNAADRGLDMYANFGSVVQIKHLSLDKDLAENIVTSLTANRIIIVCKSAEEEVINSLLNQIGWQARIQSIITIDELIDWYDKALIGKYSELLGEKVIATLSEEIKNEFPS.VGNNDFQNFKKNRGY...........
W4PB60_9BACE/6-343                 .AKQALDKIISKGRVHLYKPIQIAEILYRDRVRGDI..DLADLDTYRNASKRWRDVVCLRFLGRTSTSSARYQDDVFNENAVPPSVLEVLGAENRQNNGVVEKYIYDRFEQRFSQMSSGLD..YCSTHDKSNFQVIEFINLFWNEPGLRRSVDKIYEIVVYALFSALIECLKVKVTVEADKAKQKLLEEFSDFSERVIGLSKE.RSTVTVNARINRVGVTNAADRGLDMWANFGMAIQIKHLSLTEELAENIVSSVSSDRIVIVCKDSEEKLIVSLLTQIGWKSRIQSIVTEDDLILWYEKALRGTFAEEIGDKVLSTLYDEILLEFPA.TNSDDFNDFKHSRGY...........
A0A132GSM1_9BACT/8-344             .AKQALDSIIKKSRVHLYKPIQIGEILYHYRVKHDV..DLDDLESYRTKSKKWRDEVTTVLVGRTSTSSAKYQDNLFDENAMPPRLIKILALENVRTRGAVEAYIYSKFTNKHSQLAEALS..ICNNATKNDFNVKSFIDSFWDEPGLKRSLDKIYEIIVFSLFSTLVERLNLQVEVSVDSAKLDILSDFQDFAKMVMCIDINvQKSSKQRAKVYRVGVTNAADRGLDMYSNWGPAIQIKHLSLDVELAQSIVTSISSDRIVIVCKDAEKDVILSLLNQIGWRSRIQSIVTEDDLVRWYEKALRGSHAELLGDTLLETMRKELANEFPSiDET---PE-------iikrrry....
A0A0A2FJY0_9PORP/6-343             .AKLALDRLISKARVHLYKPIQIAEILHRDRVYGDI..DLVDLESYRNASKKWRDEVCLRFLGRTSSSSARYQDDLFNENAIPPSILRILGEENRAGGGIVEKYIYDCFEERFSQMSQGLR..YCKIHDKQSFLVKDFIDIFWNEPGLRRSIDKIYEIVVYALFSTLVESLKVKITIESDTDKQDLLHEFSDFAERVIGLSDQ.QSKITMSARINRVGVTNAADRGLDMWANFGMAIQIKHLSLTEELAENIVSSVSSDRIVIVCKDSEEKIIVSLLTQIGWKSKIQSIVTENDLVYWYNKALTGAFSKEIGDRVLSTLYHEILREFPA.TNFDDLNEFKKSRGY...........
B1WXK7_CYAA5/1-260                 .-----------------------------------..-------------------------------------------MPPEILKVLDDFNKKNLGIVEKYIYDKFKEKLGIISSIIQivLVGVSCPNNFQLDNLLSLFRQEAGIKRSIDKCYEIITYSLLETVVNQLEAEITVKIPEKNYLLLQEFSDLSKVLLNVNPD.KPEWTELAHIYRVGVTNAADRGLDMWANFGPVIQVKHLTLNSAQVETIVDQIESDHIIIVCRDADASVISILMKQIGWGKRVRGIVKESQLIEWYNRCLRGKFSHQISQPLMNLLQKSFEEEFPE.--VTEIIEFYQERQY...........
I3CC74_9GAMM/7-344                 .AKYALDKIIDKARVHFYKPIQIAEILYRDRVIQDI..NLIDLATYRISSKKWRDIICLQFLGRTSASSARYQDDLFNDNAIPPPILACLGEENRIHQGIVEAYIYHRFAQRIGQLSTGLD..YCQTHDANTFQLREFLALFWHEAGLRRSIDKVYEIIVYALFSTLVEVLEVNIDVSINTEKKTILQDFEDFTEAVIQLNAK.KTHYRLKARINRTGVTNAADRGLDMWANFGLAIQVKHLSLTEELAENIVTAISADRIVIVCKDAEKKIIVSLLNQMGWKSKIQSILVESDLIRWYEKALRGEFANTIAHHILNKLSAEIQLEFPS.TDKTEFMAFLKTRGY...........
A0A0G1LHA2_9BACT/7-342             s-KIALDTIIRKSRVHFYKPIQIAEILYYHRTQKGL..NLKNLETYRNISKRWRDEVSIRLVGRKSTSSQKYQDNVFEQNAMPPNLLAALGEANKNGGGFIEAYIYKSLRVKLGSVHKVRK..YIKNSTEDAFSIQGLVDRFVKTPGLRRSIDKMYEIGVHGLFATIVRALQAQITLEIKNEDKDILIDFERFIKMVLGINAK.QTKLILPAALYRVGVTNAADRGLDMWANFGAAVQVKHLTLTPETVEEIAENIAADRIVIVCLDAEKKSIESLLKQVGWGERIQGIITLNDLDEWYRLCLNKKYRDRLGGTLLKDLLREFDAEFPS.--SAEITPFLRERGY...........
A0YZ87_LYNSP/342-679               .AKDALDNIINKARVHFYKPIQVAEILYHHRVFDDL..TLSNLNTYRKSSKKWRDIICKRFLGRITTSSSRYQDNLFEQNATPPEVLMVLGEENKSKLGIVEAYIYRKFIERYSQMTSGLA..YCMKSDIENFKLTEFIGQFQNNPGLKRSIDKIYEIVVYALFKVLIEELNVTVKVQLDFNKLDLLKEFEDFTQKVLSINSQ.NPSFTASAKFYRVGVTNAADRGLDMWANYGSAVQIKYLSLNEGLAEGIVSNITADRIVIVCRDSEERTIVSLLNQIGWKSRIQSIITQSHLEAWYEKALRGSFRNILGARLIEILIEEIKYEFPS.SESNDLVSFMEEREY...........
V8C922_9HELI/13-346                .AKTALDVVIKKSRIHLYKPIQIAEILYRDRVFGDI..DLARLETYRNKSKVWRDEMCIALLGRVSTSSAKFQDDLFN--AIPPHLLSALGAHNKNHNGIIEAYIYNQFLHKYTQLKNALS..YCINANKETFQIKEFIDLFWREAGLKRSIDKIYEIIVYALFESITKALEITITVNMNPQKAPLLEEFSDFAKSVIGIDET.TLKSTQNAHFYRLGVTNAADRGLDMYANFGAAVQIKHLSLEVQMAQNITQGVRSDKIIIVCKEAEKDIISSLLAQIGYASKIVSIITESDLTKWYEKALRGKYANKLGDEVLKNLQVEIMEEFPP.--TKDLPKMLTDRHY...........
F0F9N4_9BACT/3-86                  f-----------------------------------..-----------------------------------------------------------------------------------..--------------------------------------------------------------------------------.-------------------------------------------------------NIYLVCKDAEEKTIVSLLNQIGWKSKIQNIVTEKELIKWYKKALTGTYSELLASKLLNTLSEEMQLEFPS.LDA--LPDALTQR--hy.........
#=GC seq_cons                      .AKtALDplIcKuRVHhYKPIQIAEILY+cRlhpDl..sL.sLpoYRstSK+WRD.lshthlGRhSTSSA+aQDsLFppNAhPPplLtlLGcEN+pssGhVEAYIYppFtp+asQlssuLs..YshsushpsFplpcFls.FhsEPGL+RSlDKlYEIlVYuLFpsLVcsLplplpVplsppphslLpEFpDFschVlslstp.psphp.sA+lYRVGVTNAADRGLDMaANFGsAIQlKHLSLs.pLAEsIVsslouDRIVIVC+DAEcclIlSLLsQIGW+S+IQSIlTEs-LlpWYEKALRGpauc.LGc+LLpsLtcEIttEFPu.spsp-hspFhppRtY...........
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