GenomeNet

Database: Pfam
Entry: RE_HindIII
LinkDB: RE_HindIII
Original site: RE_HindIII 
#=GF ID   RE_HindIII
#=GF AC   PF09518.9
#=GF DE   HindIII restriction endonuclease
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.30 25.30;
#=GF TC   92.40 92.30;
#=GF NC   22.30 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7959067
#=GF RT   Cloning, analysis and expression of the HindIII R-M-encoding
#=GF RT   genes. 
#=GF RA   Nwankwo DO, Moran LS, Slatko BE, Waite-Rees PA, Dorner LF,
#=GF RA   Benner JS, Wilson GG; 
#=GF RL   Gene. 1994;150:75-80.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019043;
#=GF CC   This family includes the HindIII (recognises and cleaves
#=GF CC   A^AGCTT) restriction endonuclease.
#=GF SQ   21
#=GS A0A136K3F5_9BACT/14-296  AC A0A136K3F5.1
#=GS T2D3_HAEIN/4-293         AC P43870.1
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG D; 3-292;
#=GS A0A0F2J1C4_9BACT/10-271  AC A0A0F2J1C4.1
#=GS A0A136K3S7_9BACT/14-296  AC A0A136K3S7.1
#=GS A0A136P2E4_9BACT/13-295  AC A0A136P2E4.1
#=GS A0A0M1JEM1_9GAMM/1-138   AC A0A0M1JEM1.1
#=GS A0A077M6F5_9MICO/13-296  AC A0A077M6F5.1
#=GS E2SH10_9FIRM/1-257       AC E2SH10.1
#=GS M5QD21_9PSED/1-265       AC M5QD21.1
#=GS A0A0G1HKB4_9BACT/10-286  AC A0A0G1HKB4.1
#=GS K9TPF8_9CYAN/14-296      AC K9TPF8.1
#=GS R6W1W5_9BACT/4-288       AC R6W1W5.1
#=GS A0A109C957_9BACT/4-292   AC A0A109C957.1
#=GS R5YR05_9FIRM/3-291       AC R5YR05.1
#=GS R5LCV3_9SPIR/4-284       AC R5LCV3.1
#=GS R6VF66_9FIRM/10-314      AC R6VF66.1
#=GS A0A0M1JFZ4_9GAMM/1-86    AC A0A0M1JFZ4.1
#=GS Q7W0D9_BORPE/35-321      AC Q7W0D9.1
#=GS E1KMJ4_9BACT/7-286       AC E1KMJ4.1
#=GS G8NXP2_GRAMM/14-296      AC G8NXP2.1
#=GS A0A0A0WYL3_9SPIO/3-287   AC A0A0A0WYL3.1
A0A136K3F5_9BACT/14-296             ...............q-Y.WIEEIRKLSGHFGND..TEKLEKELEAEIKKNGVSSLIDHLRLCGNIPESYGHDTSEEKLYSKYTDCLLSLAYTALGLKSLVL.KERADAADVE..A..F..AK..D.YSFVADAKAFRLSRT..AKNQKDF.KVQAM.HGWKRG....KPYAMVVCPIYQLP.....TSSSQIYQQATTQN..VCVFTYSHLALLLAYSEKEGQAKAQQLLKKIFE.TVKALNPSK--..NAT.DYWLAI.NKTILSFSKAVEPLWSIEKGVATESI.AISKEEALTFLAQER........EKIMRMSHKEALKELIKVHKIESR....IKTISAI-s........
T2D3_HAEIN/4-293                    ..salekllslienlt--.------------NQE..FKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPL.EQRGNAGDVI..A..L..SKefN.YGLVADAKSFRLSRT..AKNQKDF.KVKAL.SEWRED....KDYAVLTAPFFQYP.....TTKSQIFKQSLDEN..VLLFSWEHLAILLQLDLEETNIFSFEQLWNFPK.KQSKKTS-VSD..AEN.NFMRDF.NKYFMDLFKIDKDTLNQLLQKEINFI.EERSLIEKEYWKKQI........NIIKNFTREEAIEALLKDINMSSK....IETIDS--fikgik...
#=GR T2D3_HAEIN/4-293         SS    ..-HHHHHHHHHHTTT--.------------TS-..HHHHHHHHHHHHHTS-HHHHHHHHHHCTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-.S-STTS-SEE..E..E..ESSSS.-EEEEEE--EETT--..---HHHH.-HHHH.HHHTTT....SSEEEEEE-GGGS-.....SSB-HHHHHHHHHT..EEEEEHHHHHHHHHTT---BTTB--HHHHTHHH.HHHCT---GGG..TTB.--HHHH.HHHHHHHHT--HHHHHHHHHHHHHHH.HHHHHHHHHHHHHHH........HHHHTS-HHHHHHHHHHHH-HHHH....HHHHHH--HHHHHT...
A0A0F2J1C4_9BACT/10-271             ..........vlllni--.---------------..---------------GKDELKALINEIGTIHEDIEHDSSEEKLYAKTADILLARALHELGINASIN.KERANCADVTgkS..S..IH..G.YSLIGDAKAFRLSRT..AKNQKDF.KVKSM.IDLKGD....HNYAILVCPFYQYP.....KSSSQIYGQALDSN..VCLLSWEHIAFLLDMNIEESKSINLSVVWNISE.RLGESVTIKDK..NKNmNFHQKG.NKLICSDLSIDYEKMISYFNSSKSAI.VHRGEEEIEFWEKRI........EIITLYSKEEAIKELILALKLKEK....INVIRRF-i........
A0A136K3S7_9BACT/14-296             ...............q-Y.WIEEIRKLSGNFGND..TDKLEKELEAEIKKNGGSSLIDHLRLCGNIPESYGHDTSEEKLYSKYTDCLLSLAYTALGLKSLVL.KERADAADVE..A..F..AK..D.YSFVADAKAFRLSRT..AKNQKDF.KVQAM.HGWKRG....KPYAMVVCPIYQLP.....TSSSQIYQQATTQN..VCVFTYSHLALLLSYSEKEGQAKAQQLLKKIFE.TVKALNPSK--..NAT.DYWLAI.NKTILSFSKAVEPLWSIEKGVATESI.AISKEEALTFLAQER........EKIMRMSHKEALKELIKVHKIESR....IKTISAI-s........
A0A136P2E4_9BACT/13-295             ..............lf--.WIEEIRKLSGKFSDD..YERLAEELAAEIANDGIASLIDHLRLCGNIPESYNRDSSEEKLYSKYTDCLLSLSFNAIGLKSIVL.SERSDAADVE..V..F..AT..D.YSFVADAKSFRLSRT..AKNQKDF.KIQAM.DTWKRG....KPNAVVVCPIYQLP.....KTSSQIYQSATSRN..VCILTYSHISLIVAYSKIDGKEKAQKLLHEIFK.TVPQLPLSK--..NAT.DYWMGI.NRTMLEFSESIQSLWQKEKQASLEAV.SIAKEADLFFLAQQR........ESIMRMSHEEALMQLIKIHKIDSK....IKTIQAI-a........
A0A0M1JEM1_9GAMM/1-138              ...............t--.---------------..------------------------------------------------------------------.----------..-..-..--..-.---------------..-------.-----.------....--------------.....-RTSHIYQQAGARS..VCIITYTHLAVFVRYTKASSTTKSMELVHEVFK.TVESMNPSK--..DAH.IYWQAV.NRKILDFDGKIAAIWKEEKQASVESI.QISRDEALGFLASER........ERIMRFTKEQAIKEVLKASNLDNK....IWAIHS--vv.......
A0A077M6F5_9MICO/13-296             .............rdr--.WVATLAESASSFAAT..SRRTFEVLRREVDVEGYEQLLSHLRFCGVIPERYRHDSTEEKAYSKYTDSVIAEALTFIGLNAVVL.DGRADMADVE..A..A..AA..D.YDLVADAKAFRLTRT..AKNQKDF.KVAAM.DRWRYS....KEFAVVVAPIDQLP.....TRNSQIYLDASSRN..VCVLSYSHLAAVVQSKVTIGEEFAVNLLRGLLA.EPGLMNPSK--..DAQ.AYWRSL.NRVLLGSASEMRDIWKVEKEANIAAV.GVLKTEGLNYYSEER........TSILRLSHQEALDRLLDSYKIDDK....IAAIRRF-a........
E2SH10_9FIRM/1-257                  ..............ms--.---------------..----------------KEDFIEIVKEIGTIPEIIEASSTEEKLYSKASDIILARCFSEIGLKAKAV.SERGNSADII..A..E..SE..HgYTLVADAKTFRLSRT..AKNQKDF.KISTL.SKWRGM...eHDFAILVAPYFQYP.....NTNSQIYSSSLSDK..VCLLSWEHMLFLLNMQVVEDVSLSLEQIWNAPT.RIERDSKIAFA.dRMN.CLFPYI.NKMVCDRISATLDDFEIQLNKCKSYI.LERSNDEIAILKTEI........QNIEGYTKEQAIKELIKSRKLNEK....ISAIMS--yk.......
M5QD21_9PSED/1-265                  ..............mq--.---------------..------------------DLAFLVVHSGYIPERYEADSSAETLYSKLIEAVVMEWAKRIGFSNSVLpTQKSSMEDVS..I..L..DD..T.NVIVCDAKSFRLGRSqaAPNVKDVlKHADI.DKWLSV....YTNKNRLGGLVVLPsqhdwKSGSDFYQYTTDKSspTACLYYEHLAFFLIS--GMRSGNLIDLYESYSE.IFPRKITKTEN..NRA.IYYTSV.EDKLLSGQ---ADLWGQYLPTAKKII.AEKVYHCAHSLESLIvfirkdieERYLNETDIEILRRKVIESEFQ--....--------qatrnlskq
A0A0G1HKB4_9BACT/10-286             ...kqiiddifqfsnk--.---------------..-SNSFELIEKKYQPIKKETLIAELIQVGIMPEVFEHDSSEEKLWSKFSDIILAKSLELLGLKSEVL.RTRGNSADVY..S..K..AK..N.YTLVSDAKCFRLSRT..AKNQKDF.KVKAL.DDWRRQ....DTYALLVSPLSQYP.....ADRSQIYHQAIEQN..VTLLSYVHLQFLIDK---GIKGDLEK-LWKTSAcVKKNYKAADQK..RGT.TYWHAI.DTLICEITKQPLGILKKYKEQEIGKT.KEVGQEGINYWTSKI........EEFKKLNREQAIKLLIKAQKIEQK....IETIKK--ai.......
K9TPF8_9CYAN/14-296                 ................EN.WVEKIKVLSGNFSGD..TKKMEEELAAEIKIKGPSTLIDHLRLCGNIPESYKHDSSEEKLYSKYTDNLLSFAYQQMGLKSIVL.TERSDAADVE..A..V..AK..S.YSFVADAKAFRVSRS..AKNQKDF.KIEAL.DGWKQG....KDYAMVVGPIYQFP.....TRSSQIYQQSSRRN..VCIFTYSHLSLLVNYALKEGSLKSETLLHEIFK.TVEALNPGK--..ISQ.DYWASV.NQTMLKFSEVIRELWTIEKKAASEST.KLAKEEGLNFLAAER........EKIMGMSHDEALQELIKVSKLESK....LYIINSI-r........
R6W1W5_9BACT/4-288                  ........aelrsaik--.---------NSIDLD..FQVASSRLQTTIFGLDRTDILPLVVEIGIIPEDIKHDSTEEKLYTKVSDILLAKSLSEMNLEVAVL.TQRSDSADII..A..QsrYH..G.YSLVGDAKTFRLSRT..AKNAKDF.KVVSM.AQWKGD....CDYSVLVCPYYQYP.....KSVSTIYKEALDHN..VSLFSWEYLYMLLKEGVTESPSCNLRELFNQSA.IIANATTVV-N..AKA.NFLQQQ.NVNIADIINMPQSRFDDYLKEIVKIL.VERGNAEIGYYESEQ........QRVKQLSREDAINELLKCLKLDNK....ISTIKQF-ieq......
A0A109C957_9BACT/4-292              .............aql--.-IDLIKTESKTDESD..FEKATNKIKGVIFSLNKEQLFPLVKEIGAIPENIDHDSTEEKLYAKTSDIILAKCFHELGLHADIT.RERANCADIV..A..KspIH..G.YTLVGDAKAFRLSRT..AKNQKDF.KVKSM.VDWKGD....NDYAVIACPYYQYP.....NSHSQIYGQALDGN..VCLFSWEHFAYFLKYNIRESRKLNLSFIWNLSA.ELSKSVTIG--..NKY.DSFHVLgNELICKHIKTAPNTLIDYLHESKQIV.ISRGTDEIEYWNTII........TQIQLYTKDQAITELITAMKINEK....ISAI----tkyikrl..
R5YR05_9FIRM/3-291                  ...........vydel--.----IKEIEKNSTED..FSKASKRLMAYVDRLKKEEISEILLDIGAIPQSIKPSSTEEKVYSKVTDIVLARCFKEVGLESEVL.EARGNSADVS..A..K..SKyhG.YSLVADSKAMRLSRT..AKNQKDF.KVGALgDNWVGD...sDTFALLCCPLYQYP.....AKKSQIYEQALNNK..TCFFSWEHFKFLIDRNIVETDTYSLEPIWSYDArLSRTCLNN---..RAM.NFFEKV.SDNLCNRTSTNKEFFYAQISKYNKYVaRRAKREKENILNNKI........SSIEKLSREDAINLLIKEEKKKTDt..mDRLIKR--le.......
R5LCV3_9SPIR/4-284                  .....rllkkinkvkf--.-------------LE..FDKATEELEDFV--YNNSNFLDILGEIGAIPESIEHDSTEEKLFSKVSDIILSRAFIEIGLNSEVL.KQRGNSADVF..A..E..SKfyG.YSLVADAKSFRMSRT..AKNQKDF.KINSL.NNWRGN....SDYAILCNPYFQYP.....KKASQIYSQSMNYN..VCLFSWEHFIFLIKNNIKENNKINFESIWNFGQ.YNSNKVLVS-N..RKE.CFLNNF.NKYLCININKNEEDFTYILRNQKSKI.KNRCDNEILYLENEI........KLINNYSKEEAIKELIKSKKLKEK....IKHIND--fik......
R6VF66_9FIRM/10-314                 ................QN.IVDESFKTNSIINHDiiSTNFQSMLEKNF---TDDQFAELLIYSGYIPDSYEKDSSQETLFSKLIEVLVCEWAKRMGFSSRFI.KQKASYEDVN..I..V..ID..N.KVIVCDAKSFRLGRSqkAPNVKDFlKLEDI.RKWM--....ARYPNKLGGLVTYPcthdwSSGSDAYQYCSDKSapTVMLPYKYLSYLLKTKSNYSTTELSE-LWDYSR.IFPNILPQKMKggNKK.AYWSKI.DSEILNITHTTSEELHNYILQADQLI.KECIQANLERLEYQKgaiiteinNSINTETDINKLKEEIIEYKIAAEtgnlTDLINRIK.........
A0A0M1JFZ4_9GAMM/1-86               ................--.---------------..------------------------------------------------------------------.----------..-..-..--..-.---------------..-------.----M.DDWKHG....KLYAMVVCPVYQLP.....TRTSHIYQQAGARS..VCIITYTHLAVFVRYTKASSTTKSMELVHEVFK.TVESMNPSK--..DAH.IYWQAV.--------------------------.---------------........------------------------....--------.........
Q7W0D9_BORPE/35-321                 ...............h-DgVVAAVVRLCADATLD..FPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVL.AERSDAADVY..A..E..CG..D.QRIVGDGKIFRLSRT..ALNPKDY.KVPSL.KKWRQGagysADYSVLLAPSFQYP.....LSRSQLYAQAIDNN..VLLLSFEQLAFLVRH---HQPGRDYRPLWEYAG.TRAGQDTAAWK..EAR.QYWHGL.NQLVARLAGQTEQALRDSYAARRQLL.QRQFDDEIAHWDAEA........QRIRGLSREQAIAELLVSKKIQAR....VDLMRGA-q........
E1KMJ4_9BACT/7-286                  .......rkeiieksk--.-------------FD..FVTASTQLEELVFKCTKDDILNIITEIGIIPEDIGHDSSEEKLYTKVSDIIFAKTLQEMGYEVQVL.RERADCADII..A..QsqFH..S.YSLVGDAKAFRLSRT..AKNAKDF.KVNSM.VHWRGD....CDYSVLACPYFQYP.....KSTSQIYKDALDGN..VSLFSWEILYILLKEDVKETQDICLKEIWNQSA.VVATSTAVD-K..SKT.NFLAAQ.NKNIAKIIGITDDKFEEYFTSVKGFL.VSRGNEEIHYYENEI........ERVKKLSRKKAIRELLTSMKLSSK....IETIKQF-i........
G8NXP2_GRAMM/14-296                 ..............ky--.WINEIKKLSGDFGAD..STRLFSELESELEVSGGQGLRSHLRLCGAIPETYNHDSSEEKLYSKYTDILASLAFTHLGVRSVVL.VERGDAADVE..C..F..AD..D.YEFVADAKAFRLSRT..AKNAKDF.KVPSM.HKWKYH....RQHAMVICPLYQMP.....SNSSQIYRQAISDD..VCILSFSHLSLLTAFAEIASPNEARRLLKQIFK.VIATLHPSK--..DAS.AYWRAI.NTTFLDFDDRLKDLWREEKLAFVEAL.ADAKQEALACLSTER........SRILRMTHAEAIQALVKFRKLDAR....EKLIKSF-s........
A0A0A0WYL3_9SPIO/3-287              fnelcslindlattmt--.---------------..FQEAGNQLEKVIFNCSKKDFMPLITEIGTIPECIGHDSTEEKLYSKVSDIILAKCFHELGLKAIVL.QERSNSADIE..AksI..YH..D.YSLVGDAKSFRLSRT..AKNQKDF.KVESM.DHWRGD....HDYSVLVCPYFQYP.....KTVSQIYGQALNNN..VSLFSWEYFSILLQNNMKETEKINLSILWNQSS.VISGDTSVA-D..KNN.CFFIPQ.NKNICNFMHISDDTFEAHLSLFKQSM.IERGEAEIDFWKRKI........EEIQTYSREKAINELIVSLKLNEK....IAAIT---kft......
#=GC SS_cons                        ..-HHHHHHHHHHTTT--.------------TS-..HHHHHHHHHHHHHTS-HHHHHHHHHHCTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-.S-STTS-SEE..E..E..ESSSS.-EEEEEE--EETT--..---HHHH.-HHHH.HHHTTT....SSEEEEEE-GGGS-.....SSB-HHHHHHHHHT..EEEEEHHHHHHHHHTT---BTTB--HHHHTHHH.HHHCT---GGG..TTB.--HHHH.HHHHHHHHT--HHHHHHHHHHHHHHH.HHHHHHHHHHHHHHH........HHHHTS-HHHHHHHHHHHH-HHHH....HHHHHH--HHHHHT...
#=GC seq_cons                       ...............h.................-...pphtppLtt.l...stpplhshlp.hGsIPEshpHDSoEEKLYSKhoDllLucshpplGLpu.VL.ppRusuADV...A..h..sc..s.YolVuDAKuFRLSRT..AKNQKDF.KVpuh.ccW+ts....csYAlllsPhaQaP.....posSQIYpQAhspN..VClhSapHLuhLlphsht-spshshc.laphsp.hlsshsssp....stp.saapsl.Nchlhshhptspshapt.hpttpphl.tpptp-plpahppch........ppIhpho+-cAIpELlcshKlpsK....IpsIpp..h........
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