GenomeNet

Database: Pfam
Entry: RE_HindIII
LinkDB: RE_HindIII
Original site: RE_HindIII 
#=GF ID   RE_HindIII
#=GF AC   PF09518.8
#=GF DE   HindIII restriction endonuclease
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.30 25.30;
#=GF TC   172.10 171.80;
#=GF NC   22.30 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7959067
#=GF RT   Cloning, analysis and expression of the HindIII R-M-encoding
#=GF RT   genes. 
#=GF RA   Nwankwo DO, Moran LS, Slatko BE, Waite-Rees PA, Dorner LF,
#=GF RA   Benner JS, Wilson GG; 
#=GF RL   Gene. 1994;150:75-80.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019043;
#=GF CC   This family includes the HindIII (recognises and cleaves
#=GF CC   A^AGCTT) restriction endonuclease.
#=GF SQ   12
#=GS R6W1W5_9BACT/4-288       AC R6W1W5.1
#=GS T2D3_HAEIN/4-293         AC P43870.1
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI C; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVP D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVI A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVH A; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVK B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3A4K D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG B; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 2E52 D; 3-292;
#=GS T2D3_HAEIN/4-293         DR PDB; 3WVG D; 3-292;
#=GS A0A0F2J1C4_9BACT/10-271  AC A0A0F2J1C4.1
#=GS R5LCV3_9SPIR/4-284       AC R5LCV3.1
#=GS R5YR05_9FIRM/3-291       AC R5YR05.1
#=GS R6VF66_9FIRM/10-314      AC R6VF66.1
#=GS A0A0G1HKB4_9BACT/10-286  AC A0A0G1HKB4.1
#=GS Q7W0D9_BORPE/35-321      AC Q7W0D9.1
#=GS E1KMJ4_9BACT/7-286       AC E1KMJ4.1
#=GS K9TPF8_9CYAN/14-296      AC K9TPF8.1
#=GS G8NXP2_GRAMM/14-296      AC G8NXP2.1
#=GS A0A0A0WYL3_9SPIO/3-287   AC A0A0A0WYL3.1
R6W1W5_9BACT/4-288                  ........aelrsaik--.---------NSIDLD..FQVASSRLQTTIFGLDRTDILPLVVEIGIIPEDIKHDSTEEKLYTKVSDILLAKSLSEMNLEVAVLTQRSDSADII..A..QsrYH..GYSLVGDAKTFRLSRT..AKNAKDF.KVVSM.AQWKGD....CDYSVLVCPYYQYP.....KSVSTIYKEALDHN..VSLFSWEYLYMLLKEGVTESPSCNLRELFNQSA.IIANATTVV-N..AKA.NFLQQQNVNIADIINMPQSRFDDYLKEIVKIL.VERGNAEIGYYESEQ........QRVKQLSREDAINELLKCLKLDNK....ISTIKQF-ieq...
T2D3_HAEIN/4-293                    ..salekllslienlt--.------------NQE..FKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPLEQRGNAGDVI..A..L..SKefNYGLVADAKSFRLSRT..AKNQKDF.KVKAL.SEWRED....KDYAVLTAPFFQYP.....TTKSQIFKQSLDEN..VLLFSWEHLAILLQLDLEETNIFSFEQLWNFPK.KQSKKTS-VSD..AEN.NFMRDFNKYFMDLFKIDKDTLNQLLQKEINFI.EERSLIEKEYWKKQI........NIIKNFTREEAIEALLKDINMSSK....IETIDS--fikgik
#=GR T2D3_HAEIN/4-293         SS    ..-HHHHHHHHHHTTT--.------------TS-..HHHHHHHHHHHHHTS-HHHHHHHHHHCTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-S-STTS-SEE..E..E..ESSSS-EEEEEE--EETT--..---HHHH.-HHHH.HHHTTT....SSEEEEEE-GGGS-.....SSB-HHHHHHHHHT..EEEEEHHHHHHHHHTT---BTTB--HHHHTHHH.HHHCT---GGG..TTB.--HHHHHHHHHHHHT--HHHHHHHHHHHHHHH.HHHHHHHHHHHHHHH........HHHHTS-HHHHHHHHHHHH-HHHH....HHHHHH--HHHHHT
A0A0F2J1C4_9BACT/10-271             ..........vlllni--.---------------..---------------GKDELKALINEIGTIHEDIEHDSSEEKLYAKTADILLARALHELGINASINKERANCADVTgkS..S..IH..GYSLIGDAKAFRLSRT..AKNQKDF.KVKSM.IDLKGD....HNYAILVCPFYQYP.....KSSSQIYGQALDSN..VCLLSWEHIAFLLDMNIEESKSINLSVVWNISE.RLGESVTIKDK..NKNmNFHQKGNKLICSDLSIDYEKMISYFNSSKSAI.VHRGEEEIEFWEKRI........EIITLYSKEEAIKELILALKLKEK....INVIRRF-i.....
R5LCV3_9SPIR/4-284                  .....rllkkinkvkf--.-------------LE..FDKATEELEDFV--YNNSNFLDILGEIGAIPESIEHDSTEEKLFSKVSDIILSRAFIEIGLNSEVLKQRGNSADVF..A..E..SKfyGYSLVADAKSFRMSRT..AKNQKDF.KINSL.NNWRGN....SDYAILCNPYFQYP.....KKASQIYSQSMNYN..VCLFSWEHFIFLIKNNIKENNKINFESIWNFGQ.YNSNKVLVS-N..RKE.CFLNNFNKYLCININKNEEDFTYILRNQKSKI.KNRCDNEILYLENEI........KLINNYSKEEAIKELIKSKKLKEK....IKHIND--fik...
R5YR05_9FIRM/3-291                  ...........vydel--.----IKEIEKNSTED..FSKASKRLMAYVDRLKKEEISEILLDIGAIPQSIKPSSTEEKVYSKVTDIVLARCFKEVGLESEVLEARGNSADVS..A..K..SKyhGYSLVADSKAMRLSRT..AKNQKDF.KVGALgDNWVGD...sDTFALLCCPLYQYP.....AKKSQIYEQALNNK..TCFFSWEHFKFLIDRNIVETDTYSLEPIWSYDArLSRTCLNN---..RAM.NFFEKVSDNLCNRTSTNKEFFYAQISKYNKYVaRRAKREKENILNNKI........SSIEKLSREDAINLLIKEEKKKTDt..mDRLIKR--le....
R6VF66_9FIRM/10-314                 ................QN.IVDESFKTNSIINHDiiSTNFQSMLEKNF---TDDQFAELLIYSGYIPDSYEKDSSQETLFSKLIEVLVCEWAKRMGFSSRFIKQKASYEDVN..I..V..ID..NKVIVCDAKSFRLGRSqkAPNVKDFlKLEDI.RKWM--....ARYPNKLGGLVTYPcthdwSSGSDAYQYCSDKSapTVMLPYKYLSYLLKTKSNYSTTELSE-LWDYSR.IFPNILPQKMKggNKK.AYWSKIDSEILNITHTTSEELHNYILQADQLI.KECIQANLERLEYQKgaiiteinNSINTETDINKLKEEIIEYKIAAEtgnlTDLINRIK......
A0A0G1HKB4_9BACT/10-286             ...kqiiddifqfsnk--.---------------..-SNSFELIEKKYQPIKKETLIAELIQVGIMPEVFEHDSSEEKLWSKFSDIILAKSLELLGLKSEVLRTRGNSADVY..S..K..AK..NYTLVSDAKCFRLSRT..AKNQKDF.KVKAL.DDWRRQ....DTYALLVSPLSQYP.....ADRSQIYHQAIEQN..VTLLSYVHLQFLIDK---GIKGDLEK-LWKTSAcVKKNYKAADQK..RGT.TYWHAIDTLICEITKQPLGILKKYKEQEIGKT.KEVGQEGINYWTSKI........EEFKKLNREQAIKLLIKAQKIEQK....IETIKK--ai....
Q7W0D9_BORPE/35-321                 ...............h-DgVVAAVVRLCADATLD..FPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVLAERSDAADVY..A..E..CG..DQRIVGDGKIFRLSRT..ALNPKDY.KVPSL.KKWRQGagysADYSVLLAPSFQYP.....LSRSQLYAQAIDNN..VLLLSFEQLAFLVRH---HQPGRDYRPLWEYAG.TRAGQDTAAWK..EAR.QYWHGLNQLVARLAGQTEQALRDSYAARRQLL.QRQFDDEIAHWDAEA........QRIRGLSREQAIAELLVSKKIQAR....VDLMRGA-q.....
E1KMJ4_9BACT/7-286                  .......rkeiieksk--.-------------FD..FVTASTQLEELVFKCTKDDILNIITEIGIIPEDIGHDSSEEKLYTKVSDIIFAKTLQEMGYEVQVLRERADCADII..A..QsqFH..SYSLVGDAKAFRLSRT..AKNAKDF.KVNSM.VHWRGD....CDYSVLACPYFQYP.....KSTSQIYKDALDGN..VSLFSWEILYILLKEDVKETQDICLKEIWNQSA.VVATSTAVD-K..SKT.NFLAAQNKNIAKIIGITDDKFEEYFTSVKGFL.VSRGNEEIHYYENEI........ERVKKLSRKKAIRELLTSMKLSSK....IETIKQF-i.....
K9TPF8_9CYAN/14-296                 ................EN.WVEKIKVLSGNFSGD..TKKMEEELAAEIKIKGPSTLIDHLRLCGNIPESYKHDSSEEKLYSKYTDNLLSFAYQQMGLKSIVLTERSDAADVE..A..V..AK..SYSFVADAKAFRVSRS..AKNQKDF.KIEAL.DGWKQG....KDYAMVVGPIYQFP.....TRSSQIYQQSSRRN..VCIFTYSHLSLLVNYALKEGSLKSETLLHEIFK.TVEALNPGK--..ISQ.DYWASVNQTMLKFSEVIRELWTIEKKAASEST.KLAKEEGLNFLAAER........EKIMGMSHDEALQELIKVSKLESK....LYIINSI-r.....
G8NXP2_GRAMM/14-296                 ..............ky--.WINEIKKLSGDFGAD..STRLFSELESELEVSGGQGLRSHLRLCGAIPETYNHDSSEEKLYSKYTDILASLAFTHLGVRSVVLVERGDAADVE..C..F..AD..DYEFVADAKAFRLSRT..AKNAKDF.KVPSM.HKWKYH....RQHAMVICPLYQMP.....SNSSQIYRQAISDD..VCILSFSHLSLLTAFAEIASPNEARRLLKQIFK.VIATLHPSK--..DAS.AYWRAINTTFLDFDDRLKDLWREEKLAFVEAL.ADAKQEALACLSTER........SRILRMTHAEAIQALVKFRKLDAR....EKLIKSF-s.....
A0A0A0WYL3_9SPIO/3-287              fnelcslindlattmt--.---------------..FQEAGNQLEKVIFNCSKKDFMPLITEIGTIPECIGHDSTEEKLYSKVSDIILAKCFHELGLKAIVLQERSNSADIE..AksI..YH..DYSLVGDAKSFRLSRT..AKNQKDF.KVESM.DHWRGD....HDYSVLVCPYFQYP.....KTVSQIYGQALNNN..VSLFSWEYFSILLQNNMKETEKINLSILWNQSS.VISGDTSVA-D..KNN.CFFIPQNKNICNFMHISDDTFEAHLSLFKQSM.IERGEAEIDFWKRKI........EEIQTYSREKAINELIVSLKLNEK....IAAIT---kft...
#=GC SS_cons                        ..-HHHHHHHHHHTTT--.------------TS-..HHHHHHHHHHHHHTS-HHHHHHHHHHCTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-S-STTS-SEE..E..E..ESSSS-EEEEEE--EETT--..---HHHH.-HHHH.HHHTTT....SSEEEEEE-GGGS-.....SSB-HHHHHHHHHT..EEEEEHHHHHHHHHTT---BTTB--HHHHTHHH.HHHCT---GGG..TTB.--HHHHHHHHHHHHT--HHHHHHHHHHHHHHH.HHHHHHHHHHHHHHH........HHHHTS-HHHHHHHHHHHH-HHHH....HHHHHH--HHHHHT
#=GC seq_cons                       ...............h.................-..hpptpppLpphl..hs+splhslltplGhIPEsIcHDSoEEKLaSKhoDIlLA+uhpclGlpupVLppRusuADV...A.....h+..sYoLVuDAKuFRLSRT..AKNtKDF.KVpuh.scW+ts....pcYulLlsPhaQYP.....pssSQIYpQAlcpN..VsLhSaEaLthLlcpshpEosshshc.LWshut.hhustssst.p..ppp.saapshNp.lsphhphsc-thpphhpphpphl.tcptppclpahcsch........ppIpphS+EcAIpELlpshKlpsK....lchIcp..h.....
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