GenomeNet

Database: Pfam
Entry: RE_HindIII
LinkDB: RE_HindIII
Original site: RE_HindIII 
#=GF ID   RE_HindIII
#=GF AC   PF09518.5
#=GF DE   HindIII restriction endonuclease
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   66.40 66.20;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7959067
#=GF RT   Cloning, analysis and expression of the HindIII R-M-encoding
#=GF RT   genes. 
#=GF RA   Nwankwo DO, Moran LS, Slatko BE, Waite-Rees PA, Dorner LF,
#=GF RA   Benner JS, Wilson GG; 
#=GF RL   Gene. 1994;150:75-80.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019043;
#=GF CC   This family includes the HindIII (recognises and cleaves
#=GF CC   A^AGCTT) restriction endonuclease.
#=GF SQ   26
#=GS E6QL80_9ZZZZ/6-299   AC E6QL80.1
#=GS D7XXS5_ECOLX/5-304   AC D7XXS5.1
#=GS C9MI18_HAEIF/6-297   AC C9MI18.1
#=GS Q7W1P8_BORPA/37-337  AC Q7W1P8.1
#=GS E1X7M9_HAEI1/1-255   AC E1X7M9.1
#=GS T2D3_HAEIN/6-297     AC P43870.1
#=GS T2D3_HAEIN/6-297     DR PDB; 3A4K A; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 2E52 B; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 3A4K D; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 2E52 D; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 3A4K B; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 2E52 A; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 3A4K C; 5-296;
#=GS T2D3_HAEIN/6-297     DR PDB; 2E52 C; 5-296;
#=GS O86268_9LACT/4-312   AC O86268.1
#=GS H1W6D3_9CYAN/6-299   AC H1W6D3.1
#=GS E1KMJ4_9BACT/8-291   AC E1KMJ4.1
#=GS Q32WH3_9ENTR/54-309  AC Q32WH3.1
#=GS E3CLH1_STRDO/19-307  AC E3CLH1.1
#=GS Q32WE8_GEOSE/5-318   AC Q32WE8.1
#=GS E6A1P0_ECOLX/1-255   AC E6A1P0.1
#=GS G8NXP2_GRAMM/6-299   AC G8NXP2.1
#=GS B5W4I9_SPIMA/6-299   AC B5W4I9.1
#=GS Q7W0D9_BORPE/29-326  AC Q7W0D9.1
#=GS Q9R871_9LACT/1-304   AC Q9R871.1
#=GS Q46974_ECOLX/31-329  AC Q46974.1
#=GS Q7WQM4_BORBR/22-322  AC Q7WQM4.1
#=GS G9BNL2_LACLC/4-312   AC G9BNL2.1
#=GS E2SH10_9FIRM/1-259   AC E2SH10.1
#=GS F4L957_BORPC/29-326  AC F4L957.1
#=GS C9ME97_HAEIF/6-297   AC C9ME97.1
#=GS Q9JP70_ECOLX/5-303   AC Q9JP70.1
#=GS F5VSS6_STROR/3-163   AC F5VSS6.1
#=GS F5VSS5_STROR/1-85    AC F5VSS5.1
E6QL80_9ZZZZ/6-299              ......ltekaiqrrr------H........WTDEIAKISGKFGDDSAKVDRELIAELERDGISALLDHLHLCGSIPEHYGHGSSEEKLYSKYTDALLAAAYRHIGLTSLVL.AERADSADVEAVAA..NYSLVADAKVFRVSRT..AKNQKDF.KIEALHGWK...R---.GKPHAMVVCPIYQLPARQSQ..IYQQAIARNVCIFTYSHLAVLVEFSDLVDKRQAQ..DLL....L-KILKCAEELN.PTKDSVAYWSCINREILKAGTAIEPLWQREKLATLECIAAAKGEAL-----------TMLAHEREQIMRMSREDAIKFLIQDRNIDGREKAI------------ralgdn........
D7XXS5_ECOLX/5-304              .....nfkfitedaii------Rr.....ryWIDEIVKLSGHFVNDSSRVENEIIDEVKKSGSQALLDHLRLCTAIPESYDHDSSEEKLYSKYTDALISECFKYLGLNSIVL.TERADAADVEVVCD..SYSFVADAKVFRLSRT..AKNQKDF.KVQAMDGWR...N---.TKDFAMVVCPIYQLPTKSSQ..IYQQAILRNVCVFTYTHLAVLIRYSAIATTEDSK.nLLG....E--IFKSVSLLN.PSKDSVQYWVNINRTMLSYDSRIAELWSDEKSATTEGIAVSKKMAI-----------EFLSSERTRMLMMTKDEAVSALIKMHKIDSRIDQ----INKVTDN--ni............
C9MI18_HAEIF/6-297              ....lekllslienlt-------........------------NQEFKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPL.EQRGNAGDVIALSKefNYGLVADAKSFRLSRT..AKNQKDF.KVKALSEWR...E---.DKDYAVLTAPFFQYPTTKSQ..IFKQSLDENVLLFSWEHLAILLQL----------..DLE....ETNIFSFEQLWNfPKKQSKK--TSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEERSLIEKEYWKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSND-r.............
Q7W1P8_BORPA/37-337             .........sdplphp---LLHD.......gVVAAVVRLCADATLDFPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVL.AERSDAADVYAECG..DQRIVGDGKIFRLSRT..ALNPKDY.KVPSLKKWR...QGAGySADYSVLLAPSFQYPLSRSQ..LYAQAIDNNVLLLSFEQLAFLVRHHQ-PGCDYRP..LWE....YAGTRAGQDTA-.AWKEARQYWHGLNQLVARLAGQTEQALRDSYAARRQLLQRQFDDEI-----------AHWDAEAQRIRGLSREQAIAELLVSKKIQARVDL----MRGAQRQ--ltl...........
E1X7M9_HAEI1/1-255              ...............m-------........--------------------------------------VRSIGILPEAIKPSSTQEKLFSKAGDIVLVKAFQLLNLNSKPL.EQRGNAGDVIALSKefNYGLVADAKSFRLSRT..AKNQKDF.KVKALSEWR...E---.DKDYAVLTAPFFQYPTTKSQ..IFKQSLDENVLLFSWEHLAILLQL----------..DLE....ETNIFSFEQLWNfPKKQSKK--TSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEERSLIEKEYWKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSND-r.............
T2D3_HAEIN/6-297                ....lekllslienlt-------........------------NQEFKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPL.EQRGNAGDVIALSKefNYGLVADAKSFRLSRT..AKNQKDF.KVKALSEWR...E---.DKDYAVLTAPFFQYPTTKSQ..IFKQSLDENVLLFSWEHLAILLQL----------..DLE....ETNIFSFEQLWNfPKKQSKK--TSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEERSLIEKEYWKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSND-r.............
#=GR T2D3_HAEIN/6-297     SS    ....HHHHHHHHHHTT-------........------------TS-HHHHHHHHHHHHHTS-HHHHHHHHHHHTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-.S--TTS-SEEEEESSSS-EEEEEE--EETT--..---HHHH.-HHHHHHHT...T---.TSSEEEEEE-GGGS-SSB-H..HHHHHHHHTEEEEEHHHHHHHHHT----------..T--....-BTTB--HHHHTHHHHHHTT----GGGTTB--HHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHH-HHHHHHHHHHHHHHHTSGG-G.............
O86268_9LACT/4-312              .............nle---NLVN........SEFEKLKGTGLQTVDTEKVTLDFFKMLKKISDKEFINILITSGYIPDLYVADSKEETLFTKLCEALEVDWASRMGFEANAV.TQKSSYEDVVIKIN..NKIIVSDTKSFRLGRSqqAPNVKDFvKPEDYSKWA...NRHSgQKLGGLVVYPQLHEWTRKSDahVYCSDKKNPILMLPYHYLAYFLERKDKFNPKSLE.kLWD....YEKIFPE-----.KADSRNDYWQKINNVILEITGDEKKEFKKFLNLAETKLYEFVEGRLKNLEYQKNIKIKKIEFEISSI----PDSELRDKFLKYRQEIETQYIVTFQERIQKFRL..............
H1W6D3_9CYAN/6-299              .......sedaikrre------Q........WIQKIKNLSGRFGVNVESVENELKREIKQFGSDVLIDHLRLCGNIPEEYKHDSSEEKLYSKYTDSLLSFTYNEMGLTSIVL.TEKSNSADVEAVAK..NYSFVADAKVFRLSRT..AKNQKDF.KIQALDNWK...R---.GKPYAMVVAPIYQLPTRKSQ..IYEQASSRNVCIVTYSHLSLFVNYARREGKSKAE.eLLN....Q--IFTTIPALN.PSTSAVDYWLAVNKTILSFSSIIDELWKLEKEAATESTRIAKNEGI-----------RFLASEREKIMRMNREEAVMELIKVSKIDSKINKIQSI---------sdsn..........
E1KMJ4_9BACT/8-291              .......keiiekskf-------........--------------DFVTASTQLEELVFKCTKDDILNIITEIGIIPEDIGHDSSEEKLYTKVSDIIFAKTLQEMGYEVQVL.RERADCADIIAQSQfhSYSLVGDAKAFRLSRT..AKNAKDF.KVNSMVHWR...G---.DCDYSVLACPYFQYPKSTSQ..IYKDALDGNVSLFSWEILYILLKEDVKETQDICLkeIWN....QSAVVAT-----.------S--TAVDKSKTNFLAAQNKNIAKIIGITDDKFEEYFTSVKGFLVSRGNEEIHYYENEIERVKKLSRKKAIRELLTSMKLSSKIETIKQFIEQLQK---..............
Q32WH3_9ENTR/54-309             ..............sy--EYIQN........YIQNE-HFNWSVAPNTNVIATKFSAHLRTLSLKDFSFLLCHTGYIPEIYKADSSQETLYSKLVEAMVNEWALRMKFTYSLLpTQKSSKEDITISDG..ENIIVADAKSYRLGRSqaAPNVKDAlKKGDITKWLayyDQHKyNRIGGLVAFPSQHDWKNGSDfyLYLTDKNSPIIMLFYEHMAFMLLA----GMDKNN..LLDfyrnHKDIFPN-EVFN.KIGSRKIYFDKLEQYLLNCGKFKWSEF-----------------------------------------------------------------------------setsdlivsekalr
E3CLH1_STRDO/19-307             ........clihelst-------........-----------SSLDFKKSSEQLESFINQQSNKGMVELVRSIGILPEAIKTSSSQEKLFSKAGDIVLSRALQLLNLNAKPL.EERGNAGDVVAQSVeyNYGLVADAKSFRLSRT..AKNQKDF.KVKALSEWR...G---.DKDYAVLVAPFFQYPTKNSQ..IFKQSLDENVLLFSWEHLSVLLQL----------..DIT....ETSTFTLEQLWNfPLKHSKK--TTVYSSESNFMTEFNNYFIELFKLERSRLHELLQEEILNIKLRSNDESDHWKQEIERVKSLTKDEAIEELLKEINISAKLNTINKFVEGLENE--dr............
Q32WE8_GEOSE/5-318              ...............d-AFYLMN........YVDDQFKVNAQLTEEHERIANEFLKDIKKFDDKTFNKLLVSATFIPDFYEPDSSRETLFSKLVEAMVTEWAIRMGYEAAMQ.KEKASYEDVRIAIK..DKLIVVDAKTFRLGRSqaAPNVKDFlKLEDIRKWC...SRYK.NAIGGLVTYPCLHEWKNKSDayTYCSTKDMPTVMLSYKHLAFLLDNKENFNTEKLI.eLWD....YENIFPEKLPKNlKGGNKKPYWDAINKKLIEITNVGDKEYVKCLNRYDKIINQAVKEIINFLETIIINKKEEVAREIRKL----SDKQIREAYEEYKISQETEEYQRILENVKAFRL..............
E6A1P0_ECOLX/1-255              ...............g-------........-------------------------------SQALLDHLRLCTAIPESYDHDSSEEKLYSKYTDALISECFKYLGLNSIVL.TERADAADVEVVCD..SYSFVADAKVFRLSRT..AKNQKDF.KVQAMDGWR...N---.TKDFAMVVCPIYQLPTKSSQ..IYQQAILRNVCVFTYTHLAVLIRYSAIATTEDSK.nLLG....E--IFKSVSLLN.PSKDSVQYWVNINRTMLSYDSRIAELWSDEKSATTEGIAVSKKMAI-----------EFLSSERTRMLMMTKDEAVSALIKMHKIDSRIDQ----INKVTDN--ni............
G8NXP2_GRAMM/6-299              ......sekaiqtrky-------........WINEIKKLSGDFGADSTRLFSELESELEVSGGQGLRSHLRLCGAIPETYNHDSSEEKLYSKYTDILASLAFTHLGVRSVVL.VERGDAADVECFAD..DYEFVADAKAFRLSRT..AKNAKDF.KVPSMHKWK...Y---.HRQHAMVICPLYQMPSNSSQ..IYRQAISDDVCILSFSHLSLLTAFAEIASPNEAR.rLLK....Q--IFKVIATLH.PSKDASAYWRAINTTFLDFDDRLKDLWREEKLAFVEALADAKQEAL-----------ACLSTERSRILRMTHAEAIQALVKFRKLDAREKLIKSFS--------dng...........
B5W4I9_SPIMA/6-299              .......sedaikrre------Q........WIQKIKNLSGRFGVNVESVENELKREIKQFGSDVLIDHLRLCGNIPEEYKHDSSEEKLYSKYTDSLLSFTYNEMGLTSIVL.TEKSNSADVEAVAK..NYSFVADAKVFRLSRT..AKNQKDF.KIQALDNWK...R---.GKPYAMVVAPIYQLPTRKSQ..IYEQASSRNVCIVTYSHLSLFVNYARREGKSKAE.eLLN....Q--IFTTIPALN.PSTSAVDYWLAVNKTILSFSSIIDELWKLEKEAATESTRIAKNEGI-----------RFLASEREKIMRMNREEAVMELIKVSKIDSKINKIQSI---------sdsn..........
Q7W0D9_BORPE/29-326             ............lphp---LLHD.......gVVAAVVRLCADATLDFPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVL.AERSDAADVYAECG..DQRIVGDGKIFRLSRT..ALNPKDY.KVPSLKKWR...QGAGySADYSVLLAPSFQYPLSRSQ..LYAQAIDNNVLLLSFEQLAFLVRHHQ-PGRDYRP..LWE....YAGTRAGQDTA-.AWKEARQYWHGLNQLVARLAGQTEQALRDSYAARRQLLQRQFDDEI-----------AHWDAEAQRIRGLSREQAIAELLVSKKIQARVDL----MRGAQRQ--ltl...........
Q9R871_9LACT/1-304              .............mns-------........-EFEKLKGTGLQTVDTEKVTLDFFKMLKKISDKEFINILITSGYIPDLYVADSKEETLFTKLCEALEVDWASRMGFEANAV.TQKSSYEDVVIKIN..NKIIVSDTKSFRLGRSqqAPNVKDFvKPEDYSKWA...NRHSgQKLGGLVVYPQLHEWTRKSDahVYCSDKKNPILMLPYHYLAYFLERKDKFNPKSLE.kLWD....YEKIFPE-----.KADSRNDYWQKINNVILEITGDEKKEFKKFLNLAETKLYEFVEGRLKNLEYQKNIKIKKIEFEISSI----PDSELRDKFLKYRQEIETQYIVTFQERIQKFRL..............
Q46974_ECOLX/31-329             ................NIEFINDaainrrryWTNEIVKLSGHFVNDSSRVEEEIIYEVSKSGSQALLDHLRLCTAIPESYEHDSSEEKLYSKYTDALISECFKFFGLNSIVL.TERADAADVEVVCD..SYSFVADAKVFRLSRT..AKNQKDF.KVQAMDGWR...N---.TKDFAMVVCPIYQLPVKSSQ..IYQQAILRNVCVFTYTHLAVLVKYADIVGSDVRI..LLE....E--IFRSVILMN.PSKDSVQYWTMINRTMLNYDKRIEKLWIDERIATSEGIYVLKKMAI-----------EYLSSERGRILSMSREEAVRALIKMNKIESRIEQ----IKKVTDNN-i.............
Q7WQM4_BORBR/22-322             .........sdplphp---LLHD.......gVVAAVVRLCADATLDFPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVL.AERSDAADVYAECG..DQRIVGDGKIFRLSRT..ALNPKDY.KVPSLKKWR...QGAGySADYSVLLAPSFQYPLSRSQ..LYAQAIDNNVLLLSFEQLAFLVRHHQ-PGRDYRP..LWE....YAGTRAGQDTA-.AWKEARQYWHGLNQLVARLAGQTEQALRDSYAARRQLLQRQFDDEI-----------AHWDAEAQRIRGLSREQAIAELLVSKKIQARVDL----MRGAQRQ--ltl...........
G9BNL2_LACLC/4-312              .............nle---NLVN........SEFEKLKGTGLQTVDTEKVTLDFFKMLKKISDKEFINILITSGYIPDLYVADSKEETLFTKLCEALEVDWASRMGFEANAV.TQKSSYEDVVIKIN..NKIIVSDTKSFRLGRSqqAPNVKDFvKPEDYSKWA...NRHSgQKLGGLVVYPQLHEWTRKSDahVYCSDKKNPILMLPYHYLAYFLERKDKFNPKSLE.kLWD....YEKIFPE-----.KADSRNDYWQKINNVILEITGDEKKEFKKFLNLAETKLYEFVEGRLKNLEYQKNIKIKKIEFEISSI----PDSELRDKFLKYRQEIETQYIVTFQERIQKFRL..............
E2SH10_9FIRM/1-259              ...............m-------........------------------------------SKEDFIEIVKEIGTIPEIIEASSTEEKLYSKASDIILARCFSEIGLKAKAV.SERGNSADIIAESE.hGYTLVADAKTFRLSRT..AKNQKDF.KISTLSKWR...G--M.EHDFAILVAPYFQYPNTNSQ..IYSSSLSDKVCLLSWEHMLFLLNM--QVVEDVSL..SLE....Q--IWNAPTRI-.ERDSK----IAFADRMNCLFPYINKMVCDRISATLDDFEIQLNKCKSYILERSNDEIAILKTEIQNIEGYTKEQAIKELIKSRKLNEKISAIMS----------ykns..........
F4L957_BORPC/29-326             ............lphp---LLHD.......gVVAAVVRLCADATLDFPARCARLEAAIRACTRDQIIEHLQHGGVISECIGHDSSEEKLLAKYSDVLLACALGELGFQARVL.AERSDAADVYAECG..DQRIVGDGKIFRLSRT..ALNPKDY.KVPSLKKWR...QGAGySADYSVLLAPSFQYPLSRSQ..LYAQAIDNNVLLLSFEQLAFLVRHHQ-PGRDYRP..LWE....YAGTRAGQDTA-.AWKEARQYWHGLNQLVARLAGQTEQALRDSYAARRQLLQRQFDDEI-----------AHWDAEAQRIRGLSREQAIAELLVSKKIQARVDL----MRGAQRQ--ltl...........
C9ME97_HAEIF/6-297              ....lekllslienlt-------........------------NQEFKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPL.EQRGNAGDVIALSKefNYGLVADAKSFRLSRT..AKNQKDF.KVKALSEWR...E---.DKDYAVLTAPFFQYPTTKSQ..IFKQSLDENVLLFSWEHLAILLQL----------..DLE....ETNIFSFEQLWNfPKKQSKK--TSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEKRSLIEKKYWKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSND-r.............
Q9JP70_ECOLX/5-303              ................NIEFINDaainrrryWTNEIVKLSGHFVNDSSRVEEEIIYEVSKSGSQALLDHLRLCTAIPESYEHDSSEEKLYSKYTDALISECFKFFGLNSIVL.TERADAADVEVVCD..SYSFVADAKVFRLSRT..AKNQKDF.KVQAMDGWR...N---.TKDFAMVVCPIYQLPVKSSQ..IYQQAILRNVCVFTYTHLAVLVKYADIVGSDVRI..LLE....E--IFRSVILMN.PSKDSVQYWTMINRTMLNYDKRIEKLWIDERIATSEGIYVLKKMAI-----------EYLSSERGRILSMSREEAVRALIKMNKIESRIEQ----IKKVTDNN-i.............
F5VSS6_STROR/3-163              nhnisltnkllkliye-------........--------VSDLKLDFKSQSEIIEKFIDDQDRDGIIELVRFIGVLPESIKASSSQEKLFSKAGDIILAKSLCLLNLNSKPL.EQRGNAGDVVALSIeyNYGIIADAKSFRLSRT..AKNQKDF.KVKALSDWR...K---.DKDYAVLTAPFFNIQITR--..----------------------------------..---....------------.--------------------------------------------------------------------------------------------------------vkyin.........
F5VSS5_STROR/1-85               ...............m-------........---------------------------------------------------------------------------------.--------------..----------------..-------.---------...----.--------------------..----------------------------------..---....------------.--------------------SDFNLYFMDLFKLEKEQLQELLKIEILKIEERSISEIKYWDEQIKRIKSLSREEAIEELLKEINITTKINTIDKFIKGIGD---esr...........
#=GC SS_cons                    ....HHHHHHHHHHTT-------........------------TS-HHHHHHHHHHHHHTS-HHHHHHHHHHHTEE-TTS-TTSHHHHHHHHHHHHHHHHHHHHTTEEEEE-.S--TTS-SEEEEESSSS-EEEEEE--EETT--..---HHHH.-HHHHHHHT...T---.TSSEEEEEE-GGGS-SSB-H..HHHHHHHHTEEEEEHHHHHHHHHT----------..T--....-BTTB--HHHHTHHHHHHTT----GGGTTB--HHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHH-HHHHHHHHHHHHHHHTSGG-G.............
#=GC seq_cons                   ..............h...................t..phsu..s.-hpphstcl.t.lpp.spptll-hLppsGhIPEshptDSSEEKLaSKhsDsllucshphhGhpupsL.sERusuuDVhshsp..sYtlVADAKsFRLSRT..AKNtKDF.KVpulscWR...p....sKDaulllsPhaQhPsppSQ..lYpQulspNVhlhoacHLAhLlphtt..s.c.....Lh-......tIFst..hh..stcpuhpYWpslNpshhphssphpchah-.hthspctltphhpptI...........cahppEhppIhtho+-cAlptLlpph+lpu+lcth...hcthpp.................
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