GenomeNet

Database: Pfam
Entry: RE_NgoPII
LinkDB: RE_NgoPII
Original site: RE_NgoPII 
#=GF ID   RE_NgoPII
#=GF AC   PF09521.9
#=GF DE   NgoPII restriction endonuclease
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   40.10 40.10;
#=GF NC   22.40 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019046;
#=GF CC   This family includes the NgoPII (recognises and cleaves GG^CC)
#=GF CC   restriction endonuclease.
#=GF SQ   30
#=GS F0S2I4_DESTD/5-277       AC F0S2I4.1
#=GS A0A087MZP8_9BACI/5-275   AC A0A087MZP8.1
#=GS D5ERM8_PRER2/4-268       AC D5ERM8.1
#=GS K0C131_CYCSP/2-261       AC K0C131.1
#=GS A0A0K8MDE4_9RICK/10-115  AC A0A0K8MDE4.1
#=GS G8X6Y9_FLACA/2-263       AC G8X6Y9.1
#=GS A0A0H4IT76_NEIG1/3-153   AC A0A0H4IT76.1
#=GS I3CCM7_9GAMM/2-265       AC I3CCM7.1
#=GS A0A099XQ01_9FLAO/2-262   AC A0A099XQ01.1
#=GS D1B3R6_SULD5/2-265       AC D1B3R6.1
#=GS A8MHW4_ALKOO/3-264       AC A8MHW4.1
#=GS A0A136LYY4_9BACT/1-91    AC A0A136LYY4.1
#=GS K9VY48_9CYAN/2-266       AC K9VY48.1
#=GS K9RKZ4_9CYAN/2-259       AC K9RKZ4.1
#=GS A6EU95_9BACT/2-262       AC A6EU95.1
#=GS A0A0C2ZGG6_9PROT/2-261   AC A0A0C2ZGG6.1
#=GS I4AHT4_FLELS/2-262       AC I4AHT4.1
#=GS V7PW33_9BACT/3-264       AC V7PW33.1
#=GS X2H1I1_9GAMM/3-266       AC X2H1I1.1
#=GS A0A0G0MVU1_9BACT/2-262   AC A0A0G0MVU1.1
#=GS D5VBE5_MORCB/1-47        AC D5VBE5.1
#=GS A0A136LYX9_9BACT/8-153   AC A0A136LYX9.1
#=GS A0A0G0CFJ1_9BACT/3-264   AC A0A0G0CFJ1.1
#=GS A0A166ESV4_9EURY/1-59    AC A0A166ESV4.1
#=GS V5XUW6_ENTMU/3-264       AC V5XUW6.1
#=GS R7P700_9CLOT/3-265       AC R7P700.1
#=GS A0A0G1RJ76_9BACT/2-266   AC A0A0G1RJ76.1
#=GS A0A139NAB8_9STRE/3-264   AC A0A139NAB8.1
#=GS A0A0L0QQ08_VIRPA/7-274   AC A0A0L0QQ08.1
#=GS V9H9F6_9NEIS/2-265       AC V9H9F6.1
F0S2I4_DESTD/5-277                  tiidfivnlssyikafgyglpsid--------------------VSVYR..SRVNSSGEALEHFVRDMFAG.TYNL.ESESEKIKIFSEVFSYLGNQNNPPDLMIKGGDAVEVKK.IESD.GlrKKIPLNSSYPKNKLYRTDPRITNSCRKAE....DWEEKDLIYSIGVVK..RML..IHRLYMIYGDLYAADKEVYERCFNVIKKAVKHSltdIGLEMKKTKELAKIDRVDPLGITDLRIRGMWNILSPKGT..FGDI.NGI..EEFKdeNNKVLILLRKEKLQRILQET.EEEI--.--..------------lekyfelreegfirer...
A0A087MZP8_9BACI/5-275              ........................TNLLVALRNILERNSSILTPLFRSN..GSANVAGDSLEYFVKDMFCT.GASQyQMENEKMRIYNQYLSWTGDSKHFPDFIIKNGAGVEPKK.VNGKsK..GNIALNSSYPKDYIYPDSQNIPNTTLLIEd..dNWDKKDIIYAVGNLDstNNK..LLSLWLVNGNTFIANRKVYENLITEIREAISK-...TNATLQDSKELARAIGIDPLNHANLRVRGMYELKHPEAI..FGTY.ISDivLPKE..STRIYVVMLKDDLVKLELEN.EDL---.--..------------nedlctyynqkrlfrkdic
D5ERM8_PRER2/4-268                  .......................y-NIITAIINIIKDNRRVIGNSPNSN..NRLHSLGEPLEEYIKDAFSN.SLGL.SGVD-KTRKRAEALSYGGGKNNPPDAVLKRGAAIEVKK.VESI.G..N-INLNSSYPKSHLFKNDSKISKACREIEn..gDWDVKDIIYAIGCVE..KKKnnLKSLALVYGSVYCASKECYENVFNSVKQSIEES...SELDLEETKELAHINAVDPLRITFFRARGMWGISHPFKVgsFADI.YRY..DESN..-FELMAIIPSDKYNSFENID.--ELSE.LSqrIDNLTIEDTFV-q..................
K0C131_CYCSP/2-261                  ........................SNIIKAIINIANEPIVQLRDSYTSR..NTINNIGQALEAYMQDAFAN.TISE.PSPQKRNERINEVFSYLGNQNNPPDIILKDGDAIEVKK.IQSK.G..AAIALNSSYPKSKLHSDDSKITDACRDCE....DWTAKDIIYAIGVTS..DQN..LKHLWLVYGDCYAASREIYTRIGKTIKEGVKEI...EDIEFSETKELGRVNRVDPLGITNLRIRGMWHIDNPLKV..YKDY.YEA..NETK..TFSLACIIREDKFLSFNSSD.IDSLYS.--..HNDIAIKDIEIK...................
A0A0K8MDE4_9RICK/10-115             ...............ckfgdihed-------------------------..--------------------.----.--------------------------------------.----.-..-----------------------------....---------------..---..----------------------KRKITNSIQEF...-GIELSETNEIAKIKKIDPLGITDLRVRGMWHIKHPSKV..FQYI.TTK..QSKP..--HIKALMLTSKFESFEMGI.RKQIATkCN..LQNVKIQN----pn.................
G8X6Y9_FLACA/2-263                  ........................TNILDAIYNISLIQDLSIDEIIFGN..NRANNMGEGLESFIKDSFAN.TFNE.DNNRILSEKYSVFFSYEGSKNNPPDLMIKNGDALEIKK.VESL.T..SELQLNSSHPKSKLYSSSPLINKHCKNCE....IWDEKDFIYTIGHIP..NGTkkLSSLWFVYGSIYSADEEIYLSIKNELAKSLEEN...QNLHFSVTNEIGRLNFVDPLKITNLRIRGMWLLQPPFKV..FKDY.YEY..KKES..NFQCFAFIPNDKYISFPIES.RNKVEN.--..SNNIKIENIKVK...................
A0A0H4IT76_NEIG1/3-153              ...........aclqkpakmrkng-------------------------..--------------------.----.--------------------------------------.----.-..-----------------------------....--KRKTLSIIVGVVD..KKK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGIGNI...GGIQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FNYI.YQR..NMEK..SFNFMAIINEDKWNSFNNTD.--KLLA.IQ..DSKLAISDIKIK...................
I3CCM7_9GAMM/2-265                  ........................TNLIIALKNLIQNPITDLNSFYQGS..NRANSMGDALETYIKDIFCN.SLHL.SDTE-KDKLYSQNFSYIGNQNNPPDIIIKGGDAIEVKK.IESI.S..SAIALNSSYPKSKLFRNDSRITNACKECEg.avSWEQKDIIYIIGVAP..KST..LKALWFVYGDCYAAESEIYHRVANKISQGISEI...SGVELVATNELAKVKKVDPLGITDLRVRGMWHIENPIKV..FQHI.ASI..TELH..QLTVHTILLEEKYNTFPQSD.REQLEQ.LQ..SEHFTIRNVAI-r..................
A0A099XQ01_9FLAO/2-262              ........................TNILEAIYNIANHQDFEIKSLYSGR..NRANNIGEALEKYIKDAFAG.TLGV.TDELQRIQTFNQEFSWLGSQNNPPDIMIKGGDAIEVKK.TQSA.N..TSLALNSSYPKTDLRSTSPMITKECKECE....DWTVKDLIYCVGHTT..DTN..VKSLWMVYGNSYAAKHETYQRIKTTISEGIETI...PDVVFADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FNYL.HEP..TNKD..-FELVCIIPTEKYNSFPNDS.ITKLEG.IT..QSGFSIEDKQIK...................
D1B3R6_SULD5/2-265                  ........................TNILSAFRTIISNYQTNVQHVTNGS..NRANNMGDGLEAFIKDAFAN.TFNE.TNEQTKLEVFSRIYSYSGNKNNPPDLILQNSDAIEIKK.LESA.S..TAIALNSSYPKAKLFSNSTMITTACRTCE....AWSEKDMLYAIGNVP..KTTnqLKSLWLVYGDCFCADKEVYERIQQTISSGITSI...PNVEFTQTNELGKVKKVDPLGITDLRIRGMWHIENPTKI..FNYL.YHY..DETA..TFQLICLMKKEKYEALPLED.RNAIEN.LS..NLHVTLSDIRIK...................
A8MHW4_ALKOO/3-264                  ........................TNIIRAIINLVNTPVVELKEYADSH..NRVNSMGGALEEYIKDIFAG.TVGE.IDEKKRLLKIQECFSYLGNQNNPPDSMLWGGDAIEVKK.IESK.D..AQLALNSSYPKAKLFSNSKMIKKACRACE....DWTVKDMIYTVGVVK..DSK..LSSLCMVYGIDYAADAETYEQIKEVIKDGVESI...NGVEFAETKELGRVNRVDPLGITYLRVRGMWGIENPFKV..FNYV.YER..DSSK..NFNFMALINNEKYDTLEYTD.--ELEK.LVgvKEGLELKEVNIK...................
A0A136LYY4_9BACT/1-91               .......................m-NILNALINLSKRDTYKIDELYEGN..NRINNVGDALEYFIKDGFIN.EEVS.SNEQ-RDKKYSEAFSYLGNSSNPPDFMLRGGDAFEVKK.G---.-..-----------------------------....---------------..---..---------------------------------...---------------------------------------..----.---..----..--------------------.------.--..------------kthy...............
K9VY48_9CYAN/2-266                  ........................TNILQAINTIINNPIPDLVSYYQSKsqNKINAIGEALEEFIKDVFAD.TISE.TDTIKKSKKYEQVFSHQGSQNNPPDLMIKNGDAIEVKK.INKI.G..SGIALNSSYPTAKLYQDSPMITADCRNCE....TWTEKDIIYAIGCTP..EQK..LRLLWFVYGDCYAASKETYKRISQQIAIGVNQI...PNVVFSKTKELGKVNQVDPLKITDLRIRGMWSIKNPLKV..YKYInLDY..DNSS..QFQLNVVMRQTKYLSFPEKE.RIKLES.LS..KPGFSIADNKIK...................
K9RKZ4_9CYAN/2-259                  .......................a-DILQAIKAIIDNTIPDIVSYSQGK..NRINSAGDALEDFIKDIFSE.ALKD.SDLTLKNKKYSEAFSYIGNQNNPPDIILKNGDAIEVKK.IESL.K..SSIALNSSYPKSKLYFDEPMITNSCRNCE....DWQEKDIIYAIGVVK..EKK..LQLLWLIYGDCYAADREIYQRIRNKINSGITEI...PNVEFSETKELGRVNKVDPLGITYLRIRGMWGIKNPVVV..YDYL.FEN..LDIN..TFKLIVVMKEEKYLSFPYEK.RMLLEG.IS..NQNFTIR-----k..................
A6EU95_9BACT/2-262                  ........................TNILEAIYNIVNHKNFAIREFYSGR..NRANSMGEALENYIKDAFAD.TFDS.DDEQSRLKTYNQEFSWLGSQNNPPDIMIKGGDAIEVKK.TQSA.N..SSLALNSSYPKTDLRHTSPMITSECRDCE....EWTVKDLIYCVGHTS..DTN..IKSLWMVYGSSYAAKHETYQRIKTTISDGIKTI...PDVVFADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FNYL.HEP..TDKD..-FELVCIIPLEKYNSFPNES.KSKLEG.IT..EKGFSIEDKQIK...................
A0A0C2ZGG6_9PROT/2-261              ........................SNILKAFVTIVNNNKINIDTLKSGN..NRANNMGEGLENFIKNAFAN.TLHE.DDELKRLSIFENIYAYMGNKNNPPDLILKNSDAIEIKK.LESH.S..TAIALNSSYPKAKLYANSPMITKACRECE....PWSEKDMLYAIGYTA..QSQ..LKSLWFIYGDCFCADKAIYEKIKDTISHGITSI...ADVEFTPTNELGKVKKVDPLGITDLRIRGMWHIENPTKI..FNYL.YSY..DETK..SFQLICLMKKEKYNSMPLDD.REAVER.--..LVNVSIGDVKIK...................
I4AHT4_FLELS/2-262                  ........................TNILEAIYAIIQNPIFEIKSFYTGR..NRANSVGDALENYIKDAFAN.SFHI.NDEKERMKLFNENFSWLGSQNNPPDIMIKGGDAIEVKK.TQTA.N..TNLALNSSYPKSNINSSSPMITQSCKNCE....EWTEKDLIYCVGHTT..DTT..LKSLWMVYGNIYAAGHETYERIKNTISEGIDTI...PNVEFAETKELGRVNKVDALGITNLRIRGMWQIQNPRKV..FSYL.HIP..TEKK..-FELICIIPTSNYNSFDKSS.KNKIES.IN..KVGFTIQDEKVK...................
V7PW33_9BACT/3-264                  ........................TNLLKAIRNIIANPSNDLLSQYRSL..NRMNSMGEALEFYVKDIFCD.SLKE.DNSD-KGKIYSEYFSYLGNQNNPPDIIIKNGDAIEVKKhIGAR.A..SGLALNSSYPKDYLYADSPMITTACRGCE....NWEKKDLLYVIGSIV..DSK..IKSLWFVYGDCYAASREIYEKIKDAISDGVNSL...PDIEFGETNELGRVNKVDPLGITDLRIRGMWAIKHPNKV..FDYI.SEI..SNEA..DFKVNAIMLSSKYNSFPESD.RKELES.LI..SHNLIINDIKIK...................
X2H1I1_9GAMM/3-266                  ........................TNLIKAILHLIKLPAIQISEMSDGK..NRVNNQGRGLEEFIIDLFCG.TVNE.PNERIRLEKRNELFSYIGNQNNPPDAMINAGDAIEIKK.IETA.G..AAIALNSSYPKAKLYSNSSMLAKACISCE....DWDEKDMIYVIGQIY..KHS..LKSLCFVYGVDYAASLEIYERIKLKIKQGILTI...DGVEFSETKELGRVNKVDPLGITNLRIRGMWHIDNPIKV..FNYI.YKP..KEIS..SFNLMVLINNDKYLTFSEED.RNKLEK.AEkyLENFMIEDVMIK...................
A0A0G0MVU1_9BACT/2-262              ........................TNLLIALKNLIMIQSADIEAYSKSS..NRANSMGDALEIYIRDLFCG.SSNA.KREE-KDLIYNNHFSYLGNQNNPPDLIIKGGDALEVKK.IESL.R..SGIALNSSYPKDKLYVDSPMITKDCRLCE....AWKEKDIIYCIGIIK..NNR..LIALWFVYGNCYAANKDIYERIKTRISTGLNEL...DGVELSDTEELGRVNKVDPLGITYLRIRGMWGIENPAKV..FDYI.AGI..ESNK..ELTVNAIMLKEKYDSFPEKD.RVGLEK.LV..NSSLSISDIKIK...................
D5VBE5_MORCB/1-47                   .......................m-NIINAIFNIVTDFSYELTRDLHGL..NRANQMGGALEEWVKDIFAK.----.--------------------------------------.----.-..-----------------------------....---------------..---..---------------------------------...---------------------------------------..----.---..----..--------------------.------.--..------------ly.................
A0A136LYX9_9BACT/8-153              .............averpkvgngi-------------------------..--------------------.----.--------------------------------------.----.-..-----------------------------....---KKDLVYAVGIVN..E-T..VEKVLFVYGDCYSANKDTYVRVSNMIRSGIISI...EGVEFAETSELGRVNKVDPLGITYLRMRGMWHIETPYKL..FKDQ.LIE..LDAL..DKRIISIMKKTKFDELITDElRQSLEK.--..N-----------ntiktcrlrd.........
A0A0G0CFJ1_9BACT/3-264              ........................TNILIALKNLVKDPVTNLVSRYRGV..NRANSMGDALEFYIKDLFCN.SLNE.ENLVKKDEAYSKYFSYLGNQNNPPDIMIKSGDAIEVKK.VEGL.D..AGIALNSSYPKDKLFSDSSMITTACRNAE....NWREKDLIYTIGVVK..EDK..LKALWFIYGNCYSANKEVYERIRDKISKGVNEL...QSVEFSETNELGRVNKVDPLGITYLRIRGMWGIENPIKV..FNYV.APV..NRNV..ELSVNALMLKEKYLSFPEKD.RKNLEK.LV..GDKFTIKDIKIK...................
A0A166ESV4_9EURY/1-59               ........................-------------------------..--------------------.----.--------------------------------------.----.-..-----------------------------....---------------..---..---------------------------------...-----------------------------MWGIEHPLDV..YSYL.FKE..ESDK..EFSIYGLMRKGKYDSFSDED.RKIIEN.--..DKDISIEEVKVK...................
V5XUW6_ENTMU/3-264                  .......................v-NIIDAIINIVHSGVYDLQDSYVRS..NRANSMGDALEKYIIDSFSG.LINE.FDENIRMNKIGEVFSYLGNDSNPPDAMLRGGAGIETKK.IESR.G..STLQLNSSHPKSKLYVTDPRINRHAVSAE....EWDIKDFIYAIGWVQ..QKK..LKELALIDASVYCADTSIYSDTFEAIKLGIASI...PNVDFSPTKELGRVNKVDPLGITNLRIRGMWLLENPFNV..FRYI.YIP..EENK..SFNLFGLVSEEKYNSFSNTD.--ELEK.LSneKQSLNIVDVQVK...................
R7P700_9CLOT/3-265                  ........................SNILKMINNISLYGSNEIIRDYVGN..NRANNEGNALELFVKDAFCN.SFGL.EDEEAK-KKYNEVFSYIGNNKNPPDAIIRNGDAIEVKK.-NNQ.S..NKVQLNSSYPSKKLNNNSMMINKRCRECEg.vnGWTEKDLVYFVGELG..NNK..LKYLTITYGDCFAANEDVYFSVKNTIKEKVNGI...EGFTFEETNELGKINNIDKLSITDLRIRGMWIMDNPRSI..FSYV.LDE..YNNVlsDMNVFLIMLTEKYNSFSSED.RALVEQ.--..NNLLHIHDIRIK...................
A0A0G1RJ76_9BACT/2-266              ........................TNILNAILNINHFRQNNLKGYATQY.lNRINAVGEQLEYYVKDAFTN.SFIV.DQSQ-KESAYQRVFAYLGNQNNPPDAILLQGDAFEIKK.MGTP.R..SILALNSSYPKDKLYRTDNRLTAECKRCDg..gRWLKKDIFYVVGYVA..SGI..LKHLFLIQGLCYAADKSIYENMHANLKSQIGSIirdAGLEAVNTVELGRVRRVDPLGITEFRLRGMWEIENPMSV..FSGI.YEF..NKEH..NFSLCAILKRDKYALYSAVD.RNTIEH.--..TENISVSDVSV-r..................
A0A139NAB8_9STRE/3-264              ........................ANILTAVINIIKSHNSNLQEIYIGS..NRANSMGDALEKYIVDSFAD.TILE.DDESARILKVNQVFSYLGNDSNPPDAMLKGGAAIETKK.IESR.N..SQLQLNSSSPKSKLYVDDSRLKQAAREAE....EWSEKDFIYSIGFVK..DRQ..LRELALIDASVYCADKTVYQDIFEKIKYGISSI...PNVNFSPTQELGRVNKIDPLGITSLRIRGMWLLDNPFTV..FKYI.YTP..VEEA..DFNLFALVSSQHFDNFNNKD.--ELLS.LAnnTCNLSILDVKVK...................
A0A0L0QQ08_VIRPA/7-274              ........................TNVLIALRNILERNSNKMPKVLNHKnsNRINSAGDLLEYFVKDAFCSySFNY.EMAGDKLKEYQKVFSYLGNSNNPPDFVIKHGAAVEVKK.IEGT.N.pNGIALNSSFPKDYLHSNDLRIKKECRECEneygGWAKKDMIYAVGNVK..NKK..LSSLWLIYGDCFCADKETYEKISNAIKDGVSSI...PEVEFGETKELGRVNRVDPLGITYLRIRGMWGIEHPSSI..FRSL.INL..DKVK..-THVYVLMRKETFDSIEDKP.--NLNKyVE..NNNLQMKNVTI-p..................
V9H9F6_9NEIS/2-265                  ........................SNIINAIYNLVTDFENNFNRENHGL..NRANQMGEALEEWVKDLFAN.TLHT.QNEQQRLARLSETFSYLGNQNNPPDMILKNGDAIEVKK.VIGK.D..ATLALNSSYPKDKLLASSPLLTQECRNCE...pNWREKDIIYVVGVVP..KNQ.pLQSLCMVYGVDYAANHMIYERIRHTIVTGIQQI...PDVEFTETNELAKVKKIDPLGITDLRVRGMWSIANPFKV..FNYL.YQR..DFER..PFNLMCLINLEKYQSFNNTE.--DIEQ.LVgqVPDFSIADVMIK...................
#=GC seq_cons                       ........................oNIlpAlhNIlpp...plpphhpup..NRsNshG-ALEtalKDhFss.ohp..pspp.+.phasphFSYlGNpNNPPDhhlKsGDAIElKK.lpuh.s..stlALNSSYPKs+LatssshIsptC+pCE....sWpcKDlIYslGhlt..cpp..L+pLhhlYGssYuAs+-hYp+IpspIppGlppI...ssl-Fu-TpELGRVN+VDPLGITsLRIRGMWtI-NPhKV..FsYl.hp...pppp..pFplhslh.p-KYsSFspp-.ctplEp.h...ppshsIpDlplK...................
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