GenomeNet

Database: Pfam
Entry: RE_NgoPII
LinkDB: RE_NgoPII
Original site: RE_NgoPII 
#=GF ID   RE_NgoPII
#=GF AC   PF09521.5
#=GF DE   NgoPII restriction endonuclease
#=GF AU   Bateman A
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   35.90 35.90;
#=GF NC   23.60 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019046;
#=GF CC   This family includes the NgoPII (recognises and cleaves GG^CC)
#=GF CC   restriction endonuclease.
#=GF SQ   62
#=GS A7YSC5_FRATU/1-187  AC A7YSC5.1
#=GS D1D660_NEIGO/4-165  AC D1D660.1
#=GS E1UD32_LISML/1-273  AC E1UD32.1
#=GS D0W6U2_NEILA/1-179  AC D0W6U2.1
#=GS F1W8B3_MORCA/1-47   AC F1W8B3.1
#=GS F2UTW3_9EURY/1-274  AC F2UTW3.1
#=GS F1WTT3_MORCA/1-47   AC F1WTT3.1
#=GS D2AKK8_FRATE/1-187  AC D2AKK8.1
#=GS D2AKK7_FRATE/1-66   AC D2AKK7.1
#=GS D1DYL8_NEIGO/1-132  AC D1DYL8.1
#=GS D6KWP4_9NEIS/1-266  AC D6KWP4.1
#=GS D1EHY2_NEIGO/3-154  AC D1EHY2.1
#=GS B3Z267_BACCE/6-272  AC B3Z267.1
#=GS F1VP12_MORCA/1-47   AC F1VP12.1
#=GS A7JF10_FRATL/1-187  AC A7JF10.1
#=GS D1DE21_NEIGO/4-165  AC D1DE21.1
#=GS D1EHY1_NEIGO/1-132  AC D1EHY1.1
#=GS A5FP47_DEHSB/1-265  AC A5FP47.1
#=GS E8KGI2_9PAST/1-260  AC E8KGI2.1
#=GS D1E540_NEIGO/3-154  AC D1E540.1
#=GS D1E539_NEIGO/1-132  AC D1E539.1
#=GS D1E607_NEIGO/3-154  AC D1E607.1
#=GS A6EU95_9BACT/1-263  AC A6EU95.1
#=GS G9QUQ4_9PROT/1-265  AC G9QUQ4.1
#=GS D1DYL9_NEIGO/3-154  AC D1DYL9.1
#=GS D5VBE5_MORCR/1-47   AC D5VBE5.1
#=GS F0S2I4_DESTD/1-272  AC F0S2I4.1
#=GS C9PPY4_9PAST/1-260  AC C9PPY4.1
#=GS C2MAC8_9PORP/1-264  AC C2MAC8.1
#=GS T2P2_NEIGO/1-261    AC P24617.1
#=GS D1E608_NEIGO/1-132  AC D1E608.1
#=GS D1B3R6_SULD5/1-266  AC D1B3R6.1
#=GS F1XET3_MORCA/1-47   AC F1XET3.1
#=GS A7NEN3_FRATF/1-187  AC A7NEN3.1
#=GS D5ERM8_PRER2/1-269  AC D5ERM8.1
#=GS D0W6U1_NEILA/1-60   AC D0W6U1.1
#=GS D1DKG9_NEIGO/3-144  AC D1DKG9.1
#=GS D6JJJ1_NEIGO/1-261  AC D6JJJ1.1
#=GS C6YMF9_FRATL/1-187  AC C6YMF9.1
#=GS F1WLT5_MORCA/1-47   AC F1WLT5.1
#=GS C1I0C1_NEIGO/1-261  AC C1I0C1.1
#=GS B4RR22_NEIG2/1-261  AC B4RR22.1
#=GS T2MT_METTF/1-263    AC P29565.1
#=GS C9MNU9_9BACT/1-266  AC C9MNU9.1
#=GS A4KTA2_FRATU/1-187  AC A4KTA2.1
#=GS F1X672_MORCA/1-47   AC F1X672.1
#=GS D6H576_NEIGO/3-154  AC D6H576.1
#=GS F1WDK0_MORCA/1-47   AC F1WDK0.1
#=GS O68582_FUSNU/1-267  AC O68582.1
#=GS Q79CC3_NEIGO/1-195  AC Q79CC3.1
#=GS D1DS56_NEIGO/1-261  AC D1DS56.1
#=GS B8DET6_LISMH/1-273  AC B8DET6.1
#=GS G8X6Y9_FLACA/1-264  AC G8X6Y9.1
#=GS F1XAT7_MORCA/1-265  AC F1XAT7.1
#=GS F1WJJ8_MORCA/1-47   AC F1WJJ8.1
#=GS D3KKK5_LISMN/1-273  AC D3KKK5.1
#=GS D2EGA9_9EURY/1-274  AC D2EGA9.1
#=GS F8BAW1_LISMM/1-273  AC F8BAW1.1
#=GS D1DKG8_NEIGO/1-132  AC D1DKG8.1
#=GS D6H577_NEIGO/1-132  AC D6H577.1
#=GS A8MHW4_ALKOO/1-265  AC A8MHW4.1
#=GS F1WWZ3_MORCA/1-47   AC F1WWZ3.1
A7YSC5_FRATU/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRRSSQMI.TNECRACE..DWDIKNLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
D1D660_NEIGO/4-165             tqnqssllmtaclqkpa--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.----KMRK..NGKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
E1UD32_LISML/1-273             .............msey-SNVLIALSNILER.NS...C.RLTPI...FRGNGAANAAGDSLEFFVKDMFCTGAsaYSH.QIE.KEKHYDKYLSWKGNSSNFPDFIIKEG.VGVEPKKMNG..KGvGNLALNSSFPKAYIYPDTQNLpIKELIMES..QWEKKEIVYVVGNLNE..KDdkLYRLWLAYGNTFIARESIYLDLKESIKEAV.VDL...PD..AIFVDTKEFGRIKKVDPLGNSNLRLRGMWELSHPEVV..FQ.K..YLQMNe.iPEDATKINLIITENEYENLSDKPDLSRYFNEN-RL.QVQKILI--pn....................
D0W6U2_NEILA/1-179             ................m--NIIDAIINLVNN.PV...V.GVKSH...SQSNNRANQAGDDLEEYVKDLFSGSF..NLN.ETQ.RIAQHAKAFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSINDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGTDYCADAECYLKIKIKLKT--.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------esatsaayslqk..........
F1W8B3_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEKWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
F2UTW3_9EURY/1-274             .................MTNIITAAVGIINAyKN...K.KVFSTn.kGAYGTSINNWGAYLEDFIAAAFSGSL.lIND.IKK.RQELKEKAFCYSGSQNLPPDLMLRNGgPAIEVKKHAS..DT.GGLSLNSSPPRQTLRKEDKRI.ASAARTAE..YWEERKIIYAIGTIPG..SNniIKSIQLVYGDCFAASHEFYDKVEGIIREQL.EGAgseSP..VEKYEGNELGRMNAVDPLKATYLRVRGMWEIKNPLRI..FK.EegIADYS...LSKGFTLLAMAKKAEFGKLSKESPE-ALAKLKTYA.DIKDIKII-n.....................
F1WTT3_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEKWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
D2AKK8_FRATE/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRSSSQMI.TNECRACE..DWDIKNLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
D2AKK7_FRATE/1-66              .................MTNILEAIANIVKY.RD...Y.NIKQM...YTGRNRANSVGDALEKYIKDAFAGTLgsEHS.EED.KLNIYSEKFS----------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------......................
D1DYL8_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
D6KWP4_9NEIS/1-266             .................MSNIINAIYNLVTD.FE...N.NFNRE...NHGLNRANQMGEALEEWVKDLFANTL.hTQN.EQQ.RLARLSETFSYLGNQNNPPDMILKNG.DAIEVKKVIG..KD.ATLALNSSYPKDKLLASSPLL.TQECRNCE.pNWREKDIIYVVGVVPK..NQ.pLQSLCMVYGVDYAANHMIYERIRHTIVTGI.QQI...PD..VEFTETNELAKVKKIDPLGITDLRVRGMWSIANPFKV..FN.Y..LYQRD...FERPFNLMCLINLEKYQSFNNTEDIEQLVGQVPDF.SIADVMIKN......................
D1EHY2_NEIGO/3-154             .....aclqkpakmrkn--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..-GKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
B3Z267_BACCE/6-272             ................t-TNVLVALKNILDR.NS...S.ILTPI...FRSNGSANAAGDSLEFFVKDMFCTGAsqYQY.EHE.KMRKYNEYLSWTGNSSNFPDFIIKGG.AGVEPKKLNN..QSySSLALNSSYPKDYIYPDSQNL.PRGI-DEE..EWEKKEVIYVAGNLNN..QNnkLLSLWFAYGNTMIADRSIYLNLINEIRDAV.AS-...TN..ATLIDSKELARAKGIDPLKLSNLRVRGMYELEHPHKV..FN.E..YITIDd.iPADASKIFVVMLMDDYVALEE--------------.---------qpdfsthfasgklkrteinipn
F1VP12_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEKWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
A7JF10_FRATL/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRSSSQMI.TNECRACE..DWDIKNLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
D1DE21_NEIGO/4-165             tqnqssllmtaclqkpa--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.----KMRK..NGKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMTIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D1EHY1_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVNSH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
A5FP47_DEHSB/1-265             ...............ma-TNILTAIAHLVEN.PN...T.QLHQH...NKSKTRANAMGDSLEEYIKDLFANSL.nEND.VVK.KNEIYNQKFCYFGNQNNPPDFIIKNG.DAVEVKKIET..ME.SSLALNSSYPKDKLYSTSNMI.TDACRTCE..PWSIKDLLYAIGTVKD..GN..LKALWMVYGDCYAADRSVYERIQTVISDGV.NGI...ED..IQFSPSKELGRVNKVDPLGITYMRIRGMWGIENPNKV..FN.Y..IVNID...KNARISVNSIMLKSKYDSFSTLDKAKIASLANKGL.GIKDIRIKS......................
E8KGI2_9PAST/1-260             ................m--NIINAIINLVCN.PI...T.ELVTH...YQSRNRANQAGDALEEYIKELFAGTF..GLS.EAE.RLEKISEVFSYLGNNSNPPDAMLQNG.DAIEVKKIEN..NN.SALALNSSYPKSKLLANNPMI.STACKNAE..DWVEKDLIYAVGVVDG..VN..LKHLAFVYGEDYCADEDCYLKIKSTIKLGV.ESI...AG..VEFAETKELGRVNKVDPLGITYLRVRGMWGIENPWTV..FH.Y..IYQRN...FDYNFNFMAIINEEKWNSFPNTKTL--IDLQNDHL.KITDVKIKD......................
D1E540_NEIGO/3-154             .....aclqkpakmrkn--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..-GKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMTIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D1E539_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
D1E607_NEIGO/3-154             .....aclqkpakmrkn--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..-GKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
A6EU95_9BACT/1-263             .................MTNILEAIYNIVNH.KN...F.AIREF...YSGRNRANSMGEALENYIKDAFADTF.dSDD.EQS.RLKTYNQEFSWLGSQNNPPDIMIKGG.DAIEVKKTQS..AN.SSLALNSSYPKTDLRHTSPMI.TSECRDCE..EWTVKDLIYCVGHTSD..TN..IKSLWMVYGSSYAAKHETYQRIKTTISDGI.KTI...PD..VVFADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FN.Y..LHEP-...TDKDFELVCIIPLEKYNSFPNESKSKLEGITEKGF.SIEDKQIKN......................
G9QUQ4_9PROT/1-265             .................MSNLINAVINVINN.PI...L.EIKTH...YSNKNRANNAGDALEEFIKDLFADSF..NLT.PED.RNKRWSEIFSYLGNSNNPPDIILKGG.DAIEVKKIES..KD.ASLALNSSYPKHTLRKENPML.SSACRNCE..DWHEKDIIYAVGVVKN..NK..LNSLCMVYGTEFCASEECYEKIRQKIKNGV.EAI...TT..VEFSETKELGRVNKVDPLGVTYLRIRGMWGIENPWKV..FKdD..ICKRD...LDKKFNFMCLISDKKWASFSNKEDLEKLIEEKTDIvSKKNVEVKN......................
D1DYL9_NEIGO/3-154             .....aclqkpakmrkn--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..-GKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D5VBE5_MORCR/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEEWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
F0S2I4_DESTD/1-272             .............mavk--TIIDFIVNLSSY.IKafgY.GLPSId.vSVYRSRVNSSGEALEHFVRDMFAGTY..NLEsESE.KIKIFSEVFSYLGNQNNPPDLMIKGG.DAVEVKKIESdgLR.KKIPLNSSYPKNKLYRTDPRI.TNSCRKAE..DWEEKDLIYSIGVVKR..ML..IHRLYMIYGDLYAADKEVYERCFNVIKKAVkHSL...TDigLEMKKTKELAKIDRVDPLGITDLRIRGMWNILSPKGT..FG.D..INGIEe.fKDENNKVLILLRKEKLQRILQETEEEILE------.---------kyfelreeg.............
C9PPY4_9PAST/1-260             ................m--NIINAIINLVNN.PI...T.NVVSH...YQSSNRANQAGDALEEYVKDLFAGSF..DSS.ESE.RIKKHSEVFSYLGNNSNPPDVMLKQG.DAIEVKKIEN..NN.SALALNSSYPKAKLFSNSPMI.SKACREAE..DWQEKDIIYVVGIVNK..NS..IQHLAMVYGEDYCADEECYLRIKSTIKQGI.ENI...HG..VEFSETKELGRVNKVDPLGITYMRVRGMWGIENPWSV..FQ.Y..LYKRN...LDHSFNFMALINENKWNKFKNRDEL--LAINDEHL.KITDVEIKN......................
C2MAC8_9PORP/1-264             .................MANIIDAICNITSL.TS...L.ELTSL...SNSKNRANSMGESLEMFVKDLFAGSY.nTSS.SSK.RTKLLANTFSYLGNQNNPPDAILLNG.DALEIKKIES..VS.SFLALNSSYPKRQLHSSDPML.STACRNCE..EWTTKDLIYSVGFVKK..NH..LRALAMVYGDLYCADAETYTKIKRHIKEGV.EQI...EG..IEFAQTKELGKVNRVDPLGITYLRVRGMWGIENPFTL..FQ.D..LYKIK...EEDCFDLIAVVEENKYLSFDNRYKLESLSKSLKGL.SIKDAKVR-e.....................
T2P2_NEIGO/1-261               ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D1E608_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVNSH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
D1B3R6_SULD5/1-266             .................MTNILSAFRTIISN.YQ...T.NVQHV...TNGSNRANNMGDGLEAFIKDAFANTF.nETN.EQT.KLEVFSRIYSYSGNKNNPPDLILQNS.DAIEIKKLES..AS.TAIALNSSYPKAKLFSNSTMI.TTACRTCE..AWSEKDMLYAIGNVPK..TTnqLKSLWLVYGDCFCADKEVYERIQQTISSGI.TSI...PN..VEFTQTNELGKVKKVDPLGITDLRIRGMWHIENPTKI..FN.Y..LYHYD...ETATFQLICLMKKEKYEALPLEDRNAIENLSNLHV.TLSDIRIKN......................
F1XET3_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEEWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
A7NEN3_FRATF/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRSSSQMI.TNECRACE..DWDIKKLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
D5ERM8_PRER2/1-269             .............msny--NIITAIINIIKD.NR...R.VIGNS...PNSNNRLHSLGEPLEEYIKDAFSNSL..GLS.GVD.KTRKRAEALSYGGGKNNPPDAVLKRG.AAIEVKKVES..IG.-NINLNSSYPKSHLFKNDSKI.SKACREIEngDWDVKDIIYAIGCVEK..KKnnLKSLALVYGSVYCASKECYENVFNSVKQSI.EES...SE..LDLEETKELAHINAVDPLRITFFRARGMWGISHPFKVgsFA.D..IYRYD...-ESNFELMAIIPSDKYNSFENIDELSELSQRIDNL.TIEDTFV--qn....................
D0W6U1_NEILA/1-60              .................--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..---------------------------MWGIENPWFV..FN.Y..IYQRD...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D1DKG9_NEIGO/3-144             ............kngkr--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..----KTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..ICQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D6JJJ1_NEIGO/1-261             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKVLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
C6YMF9_FRATL/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRSSSQMI.TNECRACE..DWDIKNLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
F1WLT5_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEEWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
C1I0C1_NEIGO/1-261             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
B4RR22_NEIG2/1-261             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
T2MT_METTF/1-263               .................MSNLLQAIMNIKSI.QE...R.NLGSYkgvQDSKNRMNQMGVTLEVFLKDAFCNTF..--D.IEN.KDLVYSEYFSYLGNQNNPPDMILKGG.DAVEVKKITG..IK.TSIQLNSSYPKSKLFVSDSRI.TEACKNCE..DWEVKDIIYAIGTIPN..RV..LKLMFFVYGDCYAASPSIYQRIVEEVKGGL.HS-...TG..LEFSETNELGRINRVDPLGITDLRVRGMWIIKHPIKV..FK.N..IIPPEs.iKNNNFNLIALMKAEKYKQFPKKDRKRIEAEDN--I.EVTDVKIKD......................
C9MNU9_9BACT/1-266             .................MGNILTAITAIVGN.SL...ElSGNAL...GEIQNRVNQMGAALEDYVKNAFADCI..GKD.QRT.INSLRNSTFSYLGNNTNPPDAMLKGS.DAIEIKKVES..AK.NTLQFNSSYPKNKLSSGNPKI.SVKCKNCE..EWNTKDMIYVVGHVEE..SI..LHNIFFVYGDVYCDAHNVYENVENTIKECV.QSL...DG..IESSETRELGRVNKVDHLGISSLRVRGMWVIASPFKQ..FE.Y..LYEDKakeEGYSFRLIAIIPVDKYDTFKNKSDFETFCMDH---.---------avvvndedipd...........
A4KTA2_FRATU/1-187             .................--------------.--...-.-----...--------------------------..---.---.---------------------MIKGG.DAIEVKKTQS..AN.SSLALNSSYPKADLRSSSQMI.TNECRACE..DWDIKKLIYCVGHTDD..SE..LKSLWMVYGSIYAAKQETYERIRNTISDGI.KEV...PD..VVFSETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FD.Y..LHAQ-...GSNKFELICIIPLANYQKIPDNSRNSFEKLKVDGL.NVEDKKVRD......................
F1X672_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEKWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
D6H576_NEIGO/3-154             .....aclqkpakmrkn--------------.--...-.-----...--------------------------..---.---.--------------------------.----------..--.---------------------.--------..-GKRKTLSIIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMTIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
F1WDK0_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEKWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
O68582_FUSNU/1-267             .............mknn-KNIIDAIINIVKN.PI...L.ELKEY...SISHNRANSMGEALEEYIKDVFSGTL.fEKD.ENK.RMEIISEVFSYLGNTNNPPDSILRGG.DAIEVKKIEN..KS.SSLALNSSYPKAKLYSNSSMI.TDACRSCE..KWEEKDIIYTIGTCEK..NK..LTSLIFVYGEDYAAENKIYENVKNKIKLGI.ETI...ND..LEFSETNEIGRVNRVDPLGITYFRIRGMWGIENPVKV..FD.Y..IYKRD...DSKQFNFMALINEDKYLSFSNTKELEDLEKENKNL.EIKDVRIKN......................
Q79CC3_NEIGO/1-195             .................--------------.--...-.-----...--------------------------..---.---.-------------NNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
D1DS56_NEIGO/1-261             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYIVGVVDK..KK.nLKHLAMVYGIDYCADAECYLKIKNQIKEGI.GNI...GG..IQFAETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FN.Y..IYQRN...MEKSFNFMAIINEDKWNSFNNTDKL--LAIQDSKL.AISDIKIKN......................
B8DET6_LISMH/1-273             .............msey-SNVLIALSNILER.NS...C.RLTPI...FRGNGAANAAGDSLEFFVKDMFCTGAsaYSH.QIE.KEKHYDKYLSWKGNSSNFPDFIIKEG.VGVEPKKMNG..KGvGNLALNSSFPKAYIYPDTQNLpIKELIMES..QWEKKEIVYVVGNLNE..KDdkLYRLWLAYGNTFIARESIYLDLKESIKEAV.VDL...PD..AIFVDTKEFGRIKKVDPLGNSNLRLRGMWELSHPEVV..FQ.K..YLQMNe.iPEDATKINLIITENEYENLSDKPDLSRYFNEN-RL.QVQKILI--pn....................
G8X6Y9_FLACA/1-264             .................MTNILDAIYNISLI.QD...L.SIDEI...IFGNNRANNMGEGLESFIKDSFANTF..NED.NNRiLSEKYSVFFSYEGSKNNPPDLMIKNG.DALEIKKVES..LT.SELQLNSSHPKSKLYSSSPLI.NKHCKNCE..IWDEKDFIYTIGHIPNgtKK..LSSLWFVYGSIYSADEEIYLSIKNELAKSL.EEN...QN..LHFSVTNEIGRLNFVDPLKITNLRIRGMWLLQPPFKV..FK.D..YYEYK...KESNFQCFAFIPNDKYISFPIESRNKVENSNN--I.KIENIKVKN......................
F1XAT7_MORCA/1-265             ................m--NIINAIFNIVTD.FS...R.ELTRD...LYGLNRANQMGGALEEWVKDIFANTI.hIDD.EQE.RLIRLSWVFSYLGNQNNPPDIILRNG.DAIEVKKVTN..KD.ATLALNSSYPKNKLFAHSPLI.TQSCRQCE.eNWTQKDILYIVGVVPK..NQ.tLHSLFMVYGEDYCANPNTYERIRQAISTGI.QTI...PD..IEFTSTNELAKVKKVDPLGITDLRVRGMWSIASPFKV..FD.Y..IYKRD...LTKSFNFACIINQEKYQSFNNTILIENLIGRIDGF.NIQDVYIKN......................
F1WJJ8_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEEWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
D3KKK5_LISMN/1-273             .............msey-SNVLIALSNILER.NS...C.RLTPI...FRGNGAANAAGDSLEFFVKDMFCTGAsaYSH.QIE.KEKHYDKYLSWKGNSSNFPDFIIKEG.VGVEPKKMNG..KGvGNLALNSSFPKAYIYPDTQNLpIKELIMES..QWEKKEIVYVVGNLNE..KDdkLYRLWLAYGNTFIARESIYLDLKESIKEAV.VDL...PD..AIFVDTKEFGRIKKVDPLGNSNLRLRGMWELSHPEVV..FQ.K..YLQMNe.iPEDATKINLIITENEYENLSDKPDLSRYFNEN-RL.QVQKILI--pn....................
D2EGA9_9EURY/1-274             .................MTNIITAAVGIINAyKN...K.KVFSTn.kGAYGTSINNWGAYLEDFIAAAFSGSL.lIND.IKK.RQELKEKAFCYSGSQNLPPDLMLRNGgPAIEVKKHAS..DT.GGLSLNSSPPRQTLRKEDKRI.ASAARTAE..YWEERKIIYAIGTIPG..SNniIKSIQLVYGDCFAASHEFYDKVEGIIREQL.EGAgseSP..VEKYEGNELGRMNAVDPLKATYLRVRGMWEIKNPLRI..FK.EegIADYS...LSKGFTLLAMAKKAEFGKLSKESPE-ALAKLKTYA.DIKDIKII-n.....................
F8BAW1_LISMM/1-273             .............msey-SNVLIALSNILER.NS...C.RLTPI...FRGNGAANAAGDSLEFFVKDMFCTGAsaYSH.QIE.KEKHYDKYLSWKGNSSNFPDFIIKEG.VGVEPKKMNG..KGvGNLALNSSFPKAYIYPDTQNLpIKELIMES..QWEKKEIVYVVGNLNE..KDdkLYRLWLAYGNTFIARESIYLDLKESIKEAV.VDL...PD..AIFVDTKEFGRIKKVDPLGNSNLRLRGMWELSHPEVV..FQ.K..YLQMNe.iPEDATKINLIITENEYENLSDKPDLSRYFNEN-RL.QVQKILI--pn....................
D1DKG8_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
D6H577_NEIGO/1-132             ................m--NIIDAIINLANN.PV...V.GVESH...SQSNNRANQAGDALEEYVKDLFSGSF..NLN.ETQ.RIARHAKVFSYLGNNSNPPDAMLRNG.DAIEVKKIES..KD.SALALNSSHPKSKLSVDDSML.TKACKDAE..KWEEKDIIYN------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------cr....................
A8MHW4_ALKOO/1-265             ...............ms-TNIIRAIINLVNT.PV...V.ELKEY...ADSHNRVNSMGGALEEYIKDIFAGTV.gEID.EKK.RLLKIQECFSYLGNQNNPPDSMLWGG.DAIEVKKIES..KD.AQLALNSSYPKAKLFSNSKMI.KKACRACE..DWTVKDMIYTVGVVKD..SK..LSSLCMVYGIDYAADAETYEQIKEVIKDGV.ESI...NG..VEFAETKELGRVNRVDPLGITYLRVRGMWGIENPFKV..FN.Y..VYERD...SSKNFNFMALINNEKYDTLEYTDELEKLVGVKEGL.ELKEVNIKN......................
F1WWZ3_MORCA/1-47              ................m--NIINAIFNIVTD.FS...Y.ELTRD...LHGLNRANQMGGALEEWVKDIFAK--..---.---.--------------------------.----------..--.---------------------.--------..----------------..--..------------------------------.---...--..-------------------------------------..--.-..-----...-----------------------------------.---------ly....................
#=GC seq_cons                  ...................NIlsAlhNlhpp......h.tlpp.....pu.sRANphGsuLEpalKDhFut.................................hl+tG.sulEsKKhps...s.ssLsLNSSaPKs.l..ss..l..pth+ttE..pWcpKcllYhlGhh.p..pp..LppLhhVYG..asAptphY.clcppIppul.tph...ss..l.hscTpElG+lpplDPLsho.LRlRGMWtIppPhhV..Fp....lht......ppthphhsll..tcatphspp.c......p...h.tlpch.l........................
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