#=GF ID   RE_XamI
#=GF AC   PF09572.5
#=GF DE   XamI restriction endonuclease
#=GF AU   Coggill P
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   43.30 43.10;
#=GF NC   21.30 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   415144
#=GF RT   A new restriction endonuclease from Streptomyces albus G. 
#=GF RA   Arrand JR, Myers PA, Roberts RJ; 
#=GF RL   J Mol Biol. 1978;118:127-135.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019072;
#=GF CC   This family includes the XamI (recognises GTCGAC but cleavage
#=GF CC   site unknown) restriction endonuclease.
#=GF SQ   29
#=GS A3X310_9BRAD/1-65    AC A3X310.1
#=GS G5F5M4_9ACTN/1-208   AC G5F5M4.1
#=GS A5USP4_ROSS1/55-179  AC A5USP4.1
#=GS D6CQ51_THIS3/52-308  AC D6CQ51.1
#=GS A2A145_RHORH/26-261  AC A2A145.1
#=GS E4NPA7_HALBP/49-274  AC E4NPA7.1
#=GS E2MM84_PSEUB/53-290  AC E2MM84.1
#=GS G9ABP4_RHIFH/70-315  AC G9ABP4.1
#=GS A7NLC5_ROSCS/1-95    AC A7NLC5.1
#=GS T2X1_XANCR/53-269    AC P96189.1
#=GS H2HRP3_CORDP/55-311  AC H2HRP3.1
#=GS D6AXA0_9ACTO/1-196   AC D6AXA0.1
#=GS B4VV75_9CYAN/1-208   AC B4VV75.1
#=GS F3GHL1_PSESJ/53-162  AC F3GHL1.1
#=GS D0WLN5_9ACTO/56-290  AC D0WLN5.1
#=GS D2UFF2_XANAP/53-290  AC D2UFF2.1
#=GS D8FT64_9CYAN/52-308  AC D8FT64.1
#=GS H2I6P6_CORDP/55-311  AC H2I6P6.1
#=GS E1T7P5_BURSG/85-319  AC E1T7P5.1
#=GS T2S1_STRAL/51-303    AC Q53608.1
#=GS D4JUQ2_9FIRM/52-309  AC D4JUQ2.1
#=GS E5AMB6_BURRH/53-290  AC E5AMB6.1
#=GS F3GJ70_PSESJ/1-86    AC F3GJ70.1
#=GS A1BGJ7_CHLPD/14-270  AC A1BGJ7.1
#=GS Q8PJU3_XANAC/53-290  AC Q8PJU3.1
#=GS I0V635_9PSEU/52-307  AC I0V635.1
#=GS A0MD80_PROST/52-307  AC A0MD80.1
#=GS F3ENX3_PSESL/53-290  AC F3ENX3.1
#=GS F0Q6Z0_ACIAP/58-290  AC F0Q6Z0.1
A3X310_9BRAD/1-65               ...............m-----..--...-----.--------.------------------------------...--------------------------------------------------------------.------------......---------------------.-.------.................-------------.......---..--------------------IALEAKDSSSGLNSVKRLNND.TAAKAKHFATeGGKNIVN.VALLSGVFKLSSLVSAQNSGLFLVW................
G5F5M4_9ACTN/1-208              ................-----..--...-----.--------.----------------------------ME...EGRLPTRNRQRFIDEQIPALLGVIDRLLDRQLINWLGYEHDPLSMDMYVAKSVVADRLCGTT.SDPIIRNAQEAR......QLAVIAAYLEPKGYTLIDDAS.-.VGPFEM.................PRGTFAYHKNVRMyqnarddS-NgyVNTPVDVVIMPMDPS-IDTPLLVECKSAGDFANTNKRRKEE.DTKVTQLRST.YGD-VTL.YLFLCGYFDSTYLGYEAANHMDWVW................
A5USP4_ROSS1/55-179             ................TDDLR..RL...DVTTL.RSNPGILP.TLRMCTAPPLAVDRLVGLAGVSKNLIERME...QGNLPGKTTSADLDRALTKICDILSQLLDRDIFPWLVNGTALDDRERDRSATIIADRLCSAV.ANPIIRNAQEQ-......---------------------.-.------.................-------------.......---..-----------------------------------------.----------.-------.-------------------------lg..............
D6CQ51_THIS3/52-308             ................TGNLT..NI...KPALL.RQHPEILP.TLRMSTCPPIAVDRLIGLAGVSTTLVKSME..lDKKLPVRMPIVVADAQLVKIGTIIEKMADPDIFVWIGRTEAPTEVEIHRAATIVADRLCGAV.ANPIIRNAQEKR......QLAAIKTWLEARGYKQIHGGD.G.VKFNAM.................QPGTFSFRMNVPVkl...egGVQ.qVNIPIDAVIMPKTAKAGDFPIFFEAKSAGDFTNTNKRRKEE.AVKMAQLRST.YGEQVRF.NLFLCGYFDSGYLGYEAAESIDWVW................
A2A145_RHORH/26-261             ................TVDLT..QIrlyAADILvKTDFLTVV.--RFLASPFISEDDLKILAE------TTLS...PKGLTDDGSA-----GAQRVVDVVMLGLDRNRFPWVGENRTPTDIERL-TAVISTAALIAT-.----QRVQTMRRnsskdeQEEMVASYLVSQGFTQVATRA.-.--VNSLa...............dLPAPGEFCREAMF.......GTR..---KADLVVRAWDGR----AMPIECKVSNSSTNSVKRLNND.AAVKAVVWLQeFGQLTAIpAALLAGVFKVGNLKSAQNQGLTIFW................
E4NPA7_HALBP/49-274             ................TNNFR..DI...EKEDI.REDPRIVR.ILRYLVKPKISQMKFGQFAG--VNSTNNYE...EYTLAEASTP--NHQIAQDLADFTAANLDPEKVPWLSDPTIDEEEEIEYSRRWICDKIAEQE.ATTHYRNWRKDK......QEQTVAEMLDDAGYTDSGYSG.-.-KISST................nDIPVGTYAEESKV......aGAD..V-QKADFIVRPTEDT----VIFIEAKAIGVRVDSHKRVKEI.RNKASDWKDE.-------.-------------------------fegaetvaviegwttg
E2MM84_PSEUB/53-290             ...............l-SDLNpiGI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VNSIA...PGVLKKDAAA------LRKVFGVIERVIDPHRFPWMEAGVAPTDQQRE-AALLASSVLLAA-.----QRIATERRnegkdtQETKVKDYLRSLGFEEAPTVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSATNSVKRLNND.AAVKAEYWLKqFGTAQVVpAAGLAGVFKVLNLEQAQSRGLSLFW................
G9ABP4_RHIFH/70-315             ....aavravllddel-----..--...-----.------FD.ALRYVTGPPVSEDDLGVLVT---RNVKGLN...KTDIKEKDEI------PVDVLKLVCKLADPFRFPWVADRREPTGRELR-TALAATMTMHAA-.----QSLQTERRgh.gkiVEQRLETRLTELGFVKVTGGQ.K.KKSKKGeaapaypakgritqpthHPTYPNFYGECVV.......YGR..---KVDLFIALATGR----MIALEAKDSSSGLNSTKRLLNDtAAKAKHYAAE.AGKNIIS.VALLSGVFKLSDLKAAQATGLYLVW................
A7NLC5_ROSCS/1-95               ................-----..--...-----.--------.------------------------------...--------------------------------------------------------------.------------......---------------------.-.-----M.................EPGAYAFCLNVPV.......GKTqrVNIPIDVVIQPKKLRTDRLPIRIEARSAGDFTN--KRRKEE.ATQNRRLQAT.YGKTVAF.VLFLCGYFGNDYLGCAE--------gdr.............
T2X1_XANCR/53-269               ...............l-SDLNpeAI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VESIA...PGVLKKNAEA------LRKVFGVIERVIDPHRFPWMETGGMPTEQQRE-AALLASSVLLAA-.----QRIATERRnegkdnQETMVKDYLRTLGFTEAPAAA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSSTNSVKRLNND.AAVKAEYWIKqFGT----.-------------------------aqvvpsrsl.......
H2HRP3_CORDP/55-311             ..............td--YMR..NL...TPQLI.IEKPSLLP.ALRQSTAPPIARDRLAGLANVPRTLVLTID..rDHRIPPRRDPQLLNVELQRICDIIIRLLDPELFPWLATGLEPTTAAIDKATVVIGDRYAQSF.ADPAIRNDQEAR......QLEILREYLDDKGYVEQRLAA.Q.IDIRDM.................PPGTYAAHQNVPVid..antGQR..TNMPIDLVVAPHKKLADDMPILIEAKSAGDETNTNKRRKEE.AQKLAQLRAT.YGEDEQL.VLFLTGYFGLNYLKYEAAEGIDWVW................
D6AXA0_9ACTO/1-196              ................-----..--...-----.--------.------------------------------...-------MKGDVLDTHLAKMCAVLTDLLDLDLFHWYPTGEPAEPRQRELAATVVADRLCGAI.ADPIVRNAQERR......QLALIEEWLLARGYTKKTHSA.S.LPLNTM.................QPGTFSFRQNVVV.......GSDlpVNIPVDAVIQPHTPHSHKLPILIEAKSAGDFTNTNKRRKEE.ATKIHQLQLK.YGNEISL.TLFLCGYFNTGYLGYSAAEGLDWVW................
B4VV75_9CYAN/1-208              ...............m-----..--...-----.--------.-----------------------------E..kEKKLPIRLQGNALDIELRKIGKIIERMADPDIFTWLNRSESPSQTDIYRAATIVADRLCGSV.TNPIIRNAQERR......QLAAIQNWLETRQYRKLVGQD.G.VKFDQM.................PPGTFCFRMNVPInl...etGKV..INIPVDVAIKPKSSSMDELPVFLEAKSAGDFTNVNKRRKEE.AIKMSQLRST.YGDQVQF.NLFLCGYFDSGYLGYEAAEGIDWVW................
F3GHL1_PSESJ/53-162             ...............l-SDLNpiGI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VNSIA...PGVLKKDAAA------LRKVFGVIERVIDPHRFPWMEAGVAPTDQQRE-AALLASSVLLAA-.----QRIATE--......---------------------.-.------.................-------------.......---..-----------------------------------------.----------.-------.-------------------------g...............
D0WLN5_9ACTO/56-290             ....tccltrlrdqah-----..--...---EL.LTRHGYLT.EIRYLTSPSVSEDDLKVLTD------AKLS...HSYLEKNPDA------TRNIIDVVLLGLDRERFPWLGENRMPTAEENT-AAIVSTAALIAN-.----QKVQTARRsaaknlQEDEVAKALLASGYVEVERRS.-.VDNFSR.................IPGPGEFCKESLF.......GGR..---KADLVIGLWDGR----AMPTECKVSNSSTNSVKRLNND.AAVKAKVWLReFGTASCIpAAVLSGVFKVHNLLSAQKNDLTIFW................
D2UFF2_XANAP/53-290             ...............l-SDLNpgAI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VESIA...PGVLKKNSEA------LRKVFEVIERVIDPHRFPWMEAGGAPTDQQRE-AALLASSVLLAA-.----QRIATERRnegkqnQETTVKDYLRSLGFTEAPAVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSATNSVKRLNND.AAVKAEYWIKqFGTAQVVpAAALAGVFKVLNLEQAQTRGLSLFW................
D8FT64_9CYAN/52-308             ................TANLT..NI...TSALL.QQHPEVLP.ILRMAAAPPIARDRLIGLAGVSPNLVKNME..eKQRIPPRADIATLDAELTKISQIIARLLDKDIFPWLESRQQPTDSEVQRAATIVADRLCGAI.SDPIVRNAQERR......QLTMIRQWLEQRGYSYVRGGA.G.LSFETM.................QPGTFSFRLNIPVll...qsGTK.qINIPIDVALVPIDSSPGEFPLLIEAKSAGDYTNPNKRRKEE.AIKMTQLRSN.YGNNVRF.ILFLCGYFDSGYLGYEAAEGIDWVW................
H2I6P6_CORDP/55-311             ..............td--YMR..NL...TPQLI.IEKPSLLP.ALRQSTAPPIARDRLAGLANVPRTLVLTID..rDHRIPPRRDPQLLNVELQRICDIIIRLLDPELFPWLATGLEPTTAAIDKATVVIGDRYAQSF.ADPAIRNDQEAR......QLEILREYLDDKGYVEQRLAA.Q.IDIRDM.................PPGTYAAHQNVPVid..antGQR..TNMPIDLVVAPHKKLADDMPILIEAKSAGDETNTNKRRKEE.AQKLAQLRAT.YGEDEQL.VLFLTGYFGLNYLKYEAAEGIDWVW................
E1T7P5_BURSG/85-319             gmtigaarsillddel-----..--...-----.-------SdALRYLSGPPVSEDDLGVLVT---RSIGGIS...KGAIKRSESL------ALDILSLVRKLADPSRFPWIGQNRRPSFGEIR-TAVRSTTALQAS-.----QSLQTERRgy.gkvVERRLENRLVELGFARTPAPH.RaLINDPI................dYPTYPNFYGECTV.......HGR..---KVDLFIALPTGR----MIALEAKDSSSALNSVKRLNNDtAAKAKHFAVE.GGKNIIN.VALLSGVFKPEHLIRAQEAGLHIVW................
T2S1_STRAL/51-303               ................TANMT..SI...TPEVL.KAHPKTLA.TLRMSTAPPIARDRLVGLSHGSKSLLDTME...KGKLPPRMKGDVLDTHLAKMCAVLTDLLDLDLFHWYPTGEPAEPRQRELAATVVADRLCGAI.ADPIVRNAQERR......QLALIEEWLLARGYTKKTHSA.S.LPLNTM.................QPGTFSFRQNVVV.......GSDlpVNIPVDAVIQPHTPHSHKLPILIEAKSAGDFTNTNKRRKEE.ATKIHQLQLK.YGNEISL.TLFLCGYFNTGYLGYSAAEGLDWVW................
D4JUQ2_9FIRM/52-309             ...............t-NYLN..NV...SPAIL.IEHPEVLP.ILRMSTCPPIARDRLVGLAGVSKSLVQNMEdseNPHISPRMQRAKLIEELQSISDIIIKMADPDIFTWLSERRNPDETEIMRSSTIVADRLCGAV.ADPIIRNAQEKR......QLAAITTLLESKGYTLAESGV.-.-HYDEM.................KPGSFSFHTNVPVyva.geqGDQ..VNIPVDVAILPLTANTGDMPLLLEAKSAGDFTNVNKRRKEE.AVKMQQLRNT.YGVDVSY.SLFLCGYFDSGYLGYEAAEGIDWIW................
E5AMB6_BURRH/53-290             ...............l-SDLNpgAI...TDDNLaEAYNLGLGeALRYLAGPPISDDDLQVIAD-----VDSIA...PGVLKKNPEA------LRKVFKVIERVIDLHRFPWIEAGGAPTEQQRE-AALLASSVLLAA-.----QRIATERRnegkenQETKVKDYLRSLGFTEAPAVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSATNSVKRLNND.AAVKAEYWIKqFGIAQVVpAAALAGVFKVLNLEQAQARGLSLFW................
F3GJ70_PSESJ/1-86               ................-----..--...-----.--------.------------------------------...--------------------------------------------------------------.-----RIATERRnegkdtQETKVKDYLRSLGFEEAPTVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSAN---------.----------.-------.-------------------------kqrqa...........
A1BGJ7_CHLPD/14-270             ................TGNMT..AV...TPAVI.CDHPDILP.TLRMSTCPPLAVDRLIGLSGVSSNLVKSLE..lRKKLPSKMNSGLLDEDLHRIAAIIVKMADPDIFVWLGRKTQPDNDEIHRAATIVADRLCGAV.ANPIIRNAQEKR......QLAAIKSWLEARGYRQLQNGE.A.VRFDSM.................PPGTFTFRMNVPVdl...egGVK.rVNIPVDAVVMPGKSKKGALPVFFEAKSTGDFTNTNKRRKEE.AMKMSQLRST.YGRNVRF.NLFLCGYFDSGYLGYEAAEGIDWVW................
Q8PJU3_XANAC/53-290             ...............l-SDLNpgAI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VESIA...PGVLKKNSEA------LRKVFEVIERVIDPHRFPWMEAGGAPTDQQRE-AALLASSVLLAA-.----QRIATERRnegkenQETTVKDYLRSLGFTEAPAVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSATNSVKRLNND.AAVKAEYWIKqFGTAQVVpAAALAGVFKVLNLEQAQARGLSLFW................
I0V635_9PSEU/52-307             ................TTEMR..SI...TPDVI.RKRPEIVA.TLRMATAPPIARDRLTGLASLPNGFVKKLE...SGNLPGRMSVADLDKHLESICSVIDELLDRGLFDWLDGNRAPDPQQRELAAVVVSDRRCGAV.ADPIVRNAQEAR......QLGVIEDWLVARGYTKRQHPG.S.QSLESM.................PRGTFSFRQNVPVrs...edGQR.tINMPIDAVIQPHTPFPNGFPLLIEAKSAGDFTNTNKRRKEE.ATKIRQLRST.YGNDIRL.VLFLCGYFDAGYLGYEASEGLDWVW................
A0MD80_PROST/52-307             ................TENLT..NI...QPETL.QNYPSVLP.MLRMTTCPPIARDRLVGLAGISPNLVKSME..vDNRVPPKMKPRELHEHLEKIGNIIEKMADPDIFVWKERGDKGTREEVHRASTIVADRLCGAV.ADPIIRNAQEQR......QLAAIKSWLEARGYRQLASGE.A.EDWLSM.................PKGTFSFRFNIPVtm...dgGKQ..VNIPVDAVIMRKDAKDGDFPALFEAKSAGDFTNTNKRRKEE.AIKIQQLRKT.YGHKITF.DLFLCGYFDSGYLGYEAAEGIDWVW................
F3ENX3_PSESL/53-290             ............lsdl--NLI..GI...TDDNLaEAYGLGLGeALRYLAGPPISDDDLQVIAD-----VNSIA...PGVLKKDAAA------LRKVFGVIERVIDPHRFPWMEAGVAPTDQQRE-AALLASSVLLAA-.----QRIATERRnegkdtQETKVKDYLRSLGFEEAPTVA.-.--INTIv...............kGPQAMQFCAECQL.......GER..---KADVVVRLHDTR----LMAIECKVSNSATNSVKRLNND.AAVKAEYWLKqFGTAQVVpAAGLAGVFKVLNLEQAQSRGLSLFW................
F0Q6Z0_ACIAP/58-290             ....pvnkefaaeivg-----..--...-----.--DKHQFA.ALRSLAAVPISEDDLDTLLD------ASLN...RTALKKSQEL------ADKLGQILSSSLDPKRFLWVKAGRTATPEELE-SAQLATA-LITAVsAVQAGRRGEESK.....aLEGKVAEILDAAGYTRVPKRStG.IKLISH.................FPEAGTYMRQTVL.......GGH..---NADYVVRLFDGR----LLALECKASNSAVNGFKRLNKE.VVVDAGDWHReFGHSSVVaAAAIRGVFKADNVATAQSKNVFVFW................
#=GC seq_cons                   ...................hp..tl...pst.l..t.s.hls.tLRh.suPPIucDcL.slus.....lpshp....thL..p.ps......Lp+lhsllp+hlD.chFsWhttsttPospphc.AAhlsustLhuA.......R.ApE+R......Q.shlcpaLcshGasch.tsu.....hpsh..................PsshpFptps.l.......Gpc......sDlVlt.tcs+.....hhlEsKsusshTNosKRhpp-.Ashhsphhhp.aGpt.hh.shhLsGhFcst.Lt.ttupGlshhW................
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