GenomeNet

Database: Pfam
Entry: RPM2
LinkDB: RPM2
Original site: RPM2 
#=GF ID   RPM2
#=GF AC   PF08579.9
#=GF DE   Mitochondrial ribonuclease P subunit (RPM2)
#=GF AU   Mistry J, Wood V
#=GF SE   manual
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.50;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1409716
#=GF RT   A 105-kDa protein is required for yeast mitochondrial RNase P
#=GF RT   activity. 
#=GF RA   Morales MJ, Dang YL, Lou YC, Sulo P, Martin NC; 
#=GF RL   Proc Natl Acad Sci U S A. 1992;89:9875-9879.
#=GF RN   [2]
#=GF RM   16024791
#=GF RT   Rpm2p, a component of yeast mitochondrial RNase P, acts as a
#=GF RT   transcriptional activator in the nucleus. 
#=GF RA   Stribinskis V, Heyman HC, Ellis SR, Steffen MC, Martin NC; 
#=GF RL   Mol Cell Biol. 2005;25:6546-6558.
#=GF DR   INTERPRO; IPR013888;
#=GF CC   Ribonuclease P (RNase P) generates mature tRNA molecules by
#=GF CC   cleaving their 5' ends.  RPM2 is a protein subunit of the yeast
#=GF CC   mitochondrial RNase P.  It has the ability to act as
#=GF CC   transcriptional activator in the nucleus where it plays a role
#=GF CC   in defining the steady-state levels of mRNAs for some
#=GF CC   nucleus-encoded mitochondrial components [2].
#=GF SQ   48
#=GS I2H228_TETBL/100-218      AC I2H228.1
#=GS Q75BC4_ASHGO/154-272      AC Q75BC4.2
#=GS C4QZW9_PICPG/169-288      AC C4QZW9.1
#=GS W1QF10_OGAPD/186-302      AC W1QF10.1
#=GS G8ZNG9_TORDC/178-296      AC G8ZNG9.1
#=GS A5DWP5_LODEL/327-457      AC A5DWP5.1
#=GS G8BQX3_TETPH/270-391      AC G8BQX3.1
#=GS G8B5U2_CANPC/262-388      AC G8B5U2.1
#=GS G0VBZ9_NAUCC/169-285      AC G0VBZ9.1
#=GS J7RB45_KAZNA/187-305      AC J7RB45.1
#=GS D4B3F8_ARTBC/221-334      AC D4B3F8.1
#=GS C5DP63_ZYGRC/229-346      AC C5DP63.1
#=GS G8B8J5_CANPC/259-385      AC G8B8J5.1
#=GS G8YC00_PICSO/162-289      AC G8YC00.1
#=GS G8JSB0_ERECY/172-292      AC G8JSB0.1
#=GS G8YEF0_PICSO/161-289      AC G8YEF0.1
#=GS E7QIW2_YEASZ/163-281      AC E7QIW2.1
#=GS A0A0A8L6M5_9SACH/210-328  AC A0A0A8L6M5.1
#=GS Q59MC4_CANAL/285-419      AC Q59MC4.1
#=GS H2B2G8_KAZAF/191-312      AC H2B2G8.1
#=GS Q59MB1_CANAL/285-419      AC Q59MB1.1
#=GS W6MTS9_9ASCO/215-335      AC W6MTS9.1
#=GS C5DIY7_LACTC/184-302      AC C5DIY7.1
#=GS C5MEK3_CANTT/288-417      AC C5MEK3.1
#=GS M3IMX3_CANMX/289-416      AC M3IMX3.1
#=GS G3AYV1_CANTC/157-280      AC G3AYV1.1
#=GS A5DLV0_PICGU/167-302      AC A5DLV0.2
#=GS W2S197_9EURO/198-312      AC W2S197.1
#=GS G3AFT0_SPAPN/246-371      AC G3AFT0.1
#=GS A0A0H5C2J2_CYBJA/188-304  AC A0A0H5C2J2.1
#=GS A0A099P4T0_PICKU/195-332  AC A0A099P4T0.1
#=GS F2SR18_TRIRC/222-335      AC F2SR18.1
#=GS S6E6U9_ZYGB2/192-309      AC S6E6U9.1
#=GS Q6FQG6_CANGA/166-285      AC Q6FQG6.1
#=GS A0A0F4X6N9_HANUV/319-440  AC A0A0F4X6N9.1
#=GS RPM2_YEAST/163-281        AC Q02773.1
#=GS M2MYW6_BAUCO/226-340      AC M2MYW6.1
#=GS G0WHF0_NAUDC/196-312      AC G0WHF0.1
#=GS Q6CRB1_KLULA/206-324      AC Q6CRB1.1
#=GS A0A0L0NZ68_9ASCO/161-292  AC A0A0L0NZ68.1
#=GS F2PK58_TRIEC/222-335      AC F2PK58.1
#=GS C4Y2H9_CLAL4/149-279      AC C4Y2H9.1
#=GS I2K2W3_DEKBR/228-348      AC I2K2W3.1
#=GS A3GG14_PICST/174-298      AC A3GG14.2
#=GS A7TIW8_VANPO/209-328      AC A7TIW8.1
#=GS B6QAG0_TALMQ/178-289      AC B6QAG0.1
#=GS Q6BZ89_DEBHA/170-298      AC Q6BZ89.2
#=GS K0KVB8_WICCF/202-318      AC K0KVB8.1
I2H228_TETBL/100-218                 ................................aisatai--------SAAA...ANSDQG.FD....SDSFLRTH.IAQINACFQS....RDYNKVNALYQSLKRNNI-VPPLQIYSKILLSILHRDLDL.....NDINYKVFQLLNCYQDIiI....KNK.......IAPNDSILNILLIALFKCSI-v..
Q75BC4_ASHGO/154-272                 .......................................DVRFQEDLPPWQ...LDREPC.LN....EKTFLATS.IKEIKTCMEN....EDYNKVNCIYQALKRNGI-VPPVNTFEQVLCAIKLRDMDA.....DDPEGKMVQLLNCYQDL.V....SNK.......LKPTTEIYTIVIGSLLERAA-t..
C4QZW9_PICPG/169-288                 ..................................gkksa------QIEELE...ETAEPQ.QEe.qsSTSGMEDE.IRMIHSFVSQ....KRYNEVFALYLRAKAKEIKL-DRSVYTMVLRAITKRETN-.....ETVEEKLTHLLNVYSDL.L....TSN.......IKPNKDIYELVIGSLLAGA--tk.
W1QF10_OGAPD/186-302                 ..............................mgetgetae-----------K...SEQAKE.VD....PATPLSVH.ERLIDELLSS....NRPSEVLAVYFNLRGKGL-VPTTALYNKVLRSIPQRTDTG.....ESAEDKLTHLLNVYSDM.L....SNN.......LKPSDETYELVVGPLLKGA--qn.
G8ZNG9_TORDC/178-296                 ....................................eqv---IEQVVSPWE...EDTEPC.LN....HETFLATQ.VAEIERCYAK....GDYNMINSLYQALKRNGI-VPPVNVYFKVLESLAKRDLDK.....DDLDYKMSELLTCYQDM.I....VSK.......LKPSDEIYNTVLGCLFKGSI-l..
A5DWP5_LODEL/327-457                 ..........................andtsnvkkvsda----------DE...TDHYNE.F-....NDHFLTTQ.TRLLRNAYEQysspQDLDVIYPIYQSIKRNGLTLPEVDLYDIVLRSIANRKLDSel.eiTAIENKLTNLLTVYQDL.L....CVA......gLKPSLETYTIVVTSLLDASL-a..
G8BQX3_TETPH/270-391                 ..............................nhdneqnie--------DNWP..wEENESY.LN....KETFLDSH.SQKIKENFNN....ENYEIILPLYQSIKRNDC-IPSLETYYQIIFSIINRKFDS.....NDINYKMYQILSIYEDI.I...iKHK.......MKPTEDIYNLILQSLFTSSIK...
G8B5U2_CANPC/262-388                 ......................................q-LTKTSQKSPTK...VGVEDS.F-....ENGFLESQ.IANITNAFENygdkKDLDMIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L....YAN.......LKPDNETYNLVVNAMLDSTL-k..
G0VBZ9_NAUCC/169-285                 ....................................tps-----ENDFPWE...KDTELS.LN....KNTFLNTH.INEITKCYQN....GDLNKINSLYHSLKRNNV-IPPMGIYEVVLNSIAERKLDE.....NDLDNKMFEMLTCYQDI.L....SNK.......MKPSAIVYNILLNSLFKSSI-l..
J7RB45_KAZNA/187-305                 ....................................dli-----DNTSPWE...QDTETG.LN....KDTYLQTH.LRQIDECYKT....GDYNMINSLYQSLRRNDI-VPPLQTYEIIFHSFNKRPFDDn...nLNLNEKMFQLLNCYQDL.L....KNK.......LKPTTTIYNILLFQIFKNSI-v..
D4B3F8_ARTBC/221-334                 .....................iqesivsprtpvndttpy------------...------.--....EKKQAESR.SNAIVELAKD....GAHAQVPAAFESLLRDGI-KPTASAYNALLEAAIRLHPE-.....--AHNAVPKALDVYSDM.L....RRS.......VMPNEDTYKIIVQLLSTRSL-d..
C5DP63_ZYGRC/229-346                 ....................................skq----RDSMSPWE...EDKEPC.LN....KDTFLRTH.TDQINKCYEN....GDLNSINSLYQALKRNDI-IPPLKVYEQILDSVARRQFDN.....DDLDYKIAELLTCYQDL.I....MNR.......LKPSDRIYNTVLECLFKASI-a..
G8B8J5_CANPC/259-385                 ......................................q-LTKTSQKSPTK...VGVEDS.F-....ENGFLESQ.IANITNAFENygdkKDLDIIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L....YAN.......LKPDDETYNLVVNAMLDSTL-k..
G8YC00_PICSO/162-289                 ................................gtlknds--------TEDP...EDTSNE.F-....ETRFLKTQ.TDNILEIYKSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIATRTLDNdi.nmGAIEARLTNIMTVYQHL.L....DEIs....psLRPSSTTYEIVLRELFKGAA-e..
G8JSB0_ERECY/172-292                 ...............................slrleeqy------YVSAWE...PDTESC.LN....SETFLQTN.IKEIERCVQI....KDYNRVNAIYQALKRNGI-LPPVETFAQIMRSIHLRELDS.....DDLDNKMFQLLSCYQDL.I....SNK.......LKPTDEIYTIIIGALLQGSIT...
G8YEF0_PICSO/161-289                 ................................igalknd-------QTEDP...EDTSNE.F-....ETRFLKTQ.TDNILEIYNSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIAARTLDNdi.smGAIEARLTNIMTVYQHL.L....DEIs....psLRPSSTTYEIVLRELFKGA--te.
E7QIW2_YEASZ/163-281                 ......................................s-LLKDENAPVWK...EDTEPC.LN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I....NNR.......LKPPDEIYNIVLLSLFKGSI-l..
A0A0A8L6M5_9SACH/210-328             .......................................DLRLDDSIPAWE...ADLEPC.LN....KEAFLKTQ.SRLIQDCIDA....KNYNQVNAIYQSLKRNEI-VPPLSLFEQVLTSICKRDLDQ.....DNIDNQMFELLNCYQDI.I....QNK.......LKPTVEIYHLVVGSLLSGSIR...
Q59MC4_CANAL/285-419                 .......................................QVVAEQQKQPPSqphTTTQEN.ITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L....AAG.......IKPNKETYNIVVTALLKGSLQ...
H2B2G8_KAZAF/191-312                 ...................................qrki----QDDEDPWE...KDTDES.LN....KTTFLQTH.IDQINNCYRI....EDYNKINSLYQSLKRNNI-VPPIEIYEKIFDSFNKRNFDQn..tnLLINEKMYQLLNCYQDL.I....NSK.......LKPTTTIYNSLLEQIFKNSI-i..
Q59MB1_CANAL/285-419                 .......................................QVVAEQQKQPPSqphTTTQEN.ITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L....AAS.......IKPNKETYNIVVTALLKGSLQ...
W6MTS9_9ASCO/215-335                 ................................dkqqksd--------QPPS...LDSSPSsLE...sFEDFVCVQ.TDAITQYMAA....QKFNEVYAVYQHLASHESADLPVEVYADVLAAIAKRTGTR.....ETIEEQLTLLLEVYSAL.L....QSG.......KKPNAQVYSTVISSLLKGS--rr.
C5DIY7_LACTC/184-302                 .....................................pv--SANSQASPWE...PDTEET.LN....PETFLQTQ.VAHIKHCFAV....GDYNKINALYQALVRNEI-VPPVEIYATVIESVCMRDLDN.....DNVDNRMFQLLNCYQDL.I....NNK.......LKPTEKIYSLVIGSLLKGSI-l..
C5MEK3_CANTT/288-417                 ...........................qstnvpevavee----------PA...AQKVDT.F-....EVDFLATQ.VSNITSAFDNhkcpEDLNIIYPLYQAVKRNDLTLPSIDLYNIVLKSILQRSLNNtelelSAIEERLTTLLTVYQDI.L....SIG.......LKPNKETYNLIVNALLDGSLQ...
M3IMX3_CANMX/289-416                 .............................tkkpvqteps----------SQ...PVKEDT.F-....ETDFLASK.ISSITSTFTShtnaDDLNIIYPLYQSVKRNNLNLPSIDLYNIVLKSILQRSLNNtendlVSIEERLTTLLTVYQDI.L....SIG.......MKPNKETYELVVNALLDGSLQ...
G3AYV1_CANTC/157-280                 .....................vtsvedahksepleyddf------------...------.--....-ESFKTTQ.ISKINSLFEE....EDYNLIFPIYQSLKRNHMGLGSTELYNKVLSSLLLREFDNsm.qlEDIEIRLTNLLTVYQDF.Lf.faNEQ.......MKPDFSTYNIVIGGLLKGSL-d..
A5DLV0_PICGU/167-302                 ..........................qfqekspeepqks-----------E...PEADEA.I-....-SASLATNlVNQIVTVFANhqspQDLNVIYPLYQSLKRNEITLPSIAEYNMVLKAIADRALNSev.tnEDIESKLTTLLTVYQDI.L....QASvhtksdsLKPNEETFNIILRELFQGA--nk.
W2S197_9EURO/198-312                 ................................ekstkst-----ESQSESL...TDATSA.AS....EEAYLLS-.-DKIVKLGQQ....RRYAEIPAIYQNIVEEGL-IPSVDAYNHILVSAIHLHVNY.....EPWH----KALVIWSDM.T....QRA.......VQPNDATYGILIEFLTSTAL-h..
G3AFT0_SPAPN/246-371                 .............................efvknihttq-----------S...KPVEPQ.F-....EAHFLQTQ.IDNITSAFNNfkqpQDLNIIYPLYQAIKRNELALPTVELYNIVLESIVRRSLDGes.tlQAIESKLTNLLTVYQDI.L....STG.......LKPNKSTYNLVVDSLLDSSL-k..
A0A0H5C2J2_CYBJA/188-304             .......................vhsdakyfspgeieyv------------...-----E.LT....DDTFVQHH.TQEIQRAYRM....CDYNRINALYNAMKRNGL-VPSRDVYDMVLSSIAMRDIDH.....-SVDDQMSMMLNVYSDL.I....TNK.......IKPDLHIYSTVIYQLLDKSI-k..
A0A099P4T0_PICKU/195-332             ihdlesklsklkirnldssnnkyieefkkfpniddafdh------------...------.M-....SENPLKIQ.EFTIDNLMNQ....NKFNEVLPVFNRMRNNGL-VPTLPIYNKVLKSIPLRQTN-.....ESLENNMTHLLNIYSDL.L....SNN.......IKPNMETYEIVIGSLVNSSL-l..
F2SR18_TRIRC/222-335                 ........................vqesivsprtpvndi------------...-----S.LY....EKKQAESR.SNAIVDLAKD....GAHAQVPAAFESLLRDGI-KPTASAYNVLLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L....RRS.......VMPNEDTYKIIVQLLSTRSL-d..
S6E6U9_ZYGB2/192-309                 .....................................qr---EEQFSSPWE...EDTEPC.LN....KDTFLQTH.VDHIRRCQEL....GDLNKINSLYQSLKRNDI-VPPVDVYATILDSIARRQFDK.....DDLDYKVSELLTCYQDM.I....TNK.......LKPSDEVYNTVLGCLFHSSV-i..
Q6FQG6_CANGA/166-285                 .......................................DLLELEKEYNWE...KDTDDD.LN....PQTYLSTH.IDQINKHFVK....GNYNIINALYKSLKRNGIAIQDREVLTKVLISLARREMDD.....LDIDNKVFELLSCYQDI.I....TNR.......IKPNLEIYNIVLETLFKSSI-v..
A0A0F4X6N9_HANUV/319-440             ................................vvteeyy----EKTKQIWP...ADSDLT.LN....TFKFSNTL.TEQIHKAYDN....NDLNKIYSLYLAMKRNNC-TPNVETFDLIIKSLCSRDMDN.....KDLDERMFHILTCYQDL.I....SMK.......MKPLVSTYHDIILALLNGSL-d..
RPM2_YEAST/163-281                   ......................................s-LLKDENAPVWK...EDTEPC.LN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I....NNR.......LKPPDEIYNIVLLSLFKGSI-l..
M2MYW6_BAUCO/226-340                 .............eehtvstpatlytstdsfssaeadfy------------...------.--....--------.SSEILELSAK....KEYERVPAAFQAMLRAGVQQPKPATYHALLTSVVELT---.....QGKHQKVPKALEVYSDM.L....RRK.......VTPHVESFNLLISLLARR---ase
G0WHF0_NAUDC/196-312                 ..................................thips-------SSPWE...IDTETS.LN....PKTYLSTH.INEINKAYLM....QDFNKINSLYHSLKRNNI-IPPIETFEKILDSISKRLMDK.....FDLDNKMFEMLSCYQDI.I....NNK.......LKPSNAIYNILLSSLFKNSI-m..
Q6CRB1_KLULA/206-324                 .......................................DVRLDDSIPAWE...TDLEPC.LN....KEAFLETQ.SKLIEDCMKN....KNYNQVNAIYKSLIRNEI-VPPLSLFEQVLTSICRRDLDQ.....NNIDNQMFELLNCYQDI.I....QNK.......LKPSAEIYHLVVGSLLSGSIR...
A0A0L0NZ68_9ASCO/161-292             ............................llqpkieelpv------------...EPTEEQ.PF....EDSFQKTQ.AENIMRIYNNhtssEELDVIYPLYQSLKRNDIPLPSILHYNIVLESILLRLLDNqtlslTAIESRLTNLLTVYQDV.LrfcsKSS.......LKPDSTTYDLVLKGVFDGCV-d..
F2PK58_TRIEC/222-335                 ........................vqesivsprtpvndi------------...-----S.LY....EKKQAESR.SNAIVELAKD....GAHAKVPAAFESLLRDGV-KPTASAYNALLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L....RRS.......VMPNEDTYKIIVQLLSTRSL-d..
C4Y2H9_CLAL4/149-279                 ..............................tsskvpsen----------IP...EKEEDD.F-....ESSFQKSQ.VDKIVNTFIShecpEDLNVIYPLYQGLKRNHIPLPSVHEYNIVLKSISMRELDSqc.tiSAIESKLTSLLTVYEDL.L....AVCsr..daaFKPNTETYNVILADIFKGAL-e..
I2K2W3_DEKBR/228-348                 ..............................edeeekeva----DNVEQKVN...AQTAGD.FS....PETYSDEE.I--IDNMMAV....GKVNEVLSVYLRLRSNNI-VPSIKVYNKVMESIRLRETD-.....ETMEQKLTNLLNVYSDM.L....SNS.......IKPDNISYELVIKSLVEGSL-h..
A3GG14_PICST/174-298                 ...................................kita------ETPSLR...TDTDGS.F-....ESNFLHNQ.IAAITSTYSSytdaSELNIIYPLYQSLKRNDLTLPSIQLYNIVLSSIEKRALDSef.tlEAIENKLTNLLTVYQDI.L....SSG.......NKPDTETYNLIIRNLLQGNL-d..
A7TIW8_VANPO/209-328                 ..................................tinni-----NNDFPWE...KDNEES.LN....KDTYLKAH.MDSIDKAFIK....KDYNIINALYQSLKRNDC-VPSIETYYKILYSIAHRDLDS.....DDINYKMFQILSCYEDIiI....KNK.......LKPTDEIYSVLLENLFKGSI-i..
B6QAG0_TALMQ/178-289                 .............denavdstaheltidvnaeksivasg------------...------.--....--------.--RVVQLAVE....EKYAEIPAAFEAILRDGV-TPSVEAYNSLLQAAIKLHTDS.....YH---AVPKALDVYSDM.L....RRR.......VIPNQETYKTLIAVLVSRAV-e..
Q6BZ89_DEBHA/170-298                 .....................................qi---NETAYEELI...EDKEED.F-....ESNLLHTQ.ISNIEAIYAKq.gpTELNLIYPLYQTLKRNCLQLPSIHLYNIVLKSIVERKLDNdartfENIESRLTNLLTVYQDI.L....VGSs....eqVKPNKETYEIVLNELLRGSLQ...
K0KVB8_WICCF/202-318                 .........................kpilqspdqyneli------------...---PEE.QN....DETFLTQQ.TNQILEANDS....YQYEKIHSLYMAIKRNNI-IPSRELYAIVLSSIVERKID-.....DSLDDKLSTLLNVYQDL.V....SNK.......IKPDSQIYSIVINKLLSASI-e..
#=GC seq_cons                        ....................................p.............p...tss-.s.h.....cpsFLpop.hspIspsaps....p-hNhI.uLYQuLKRNsl.lPslclYshVLcSIscRphDs.....psl-pKlspLLslYQDl.l....ssp.......lKPss-sYslVlpsLhcuSl....
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