GenomeNet

Database: Pfam
Entry: RPM2
LinkDB: RPM2
Original site: RPM2 
#=GF ID   RPM2
#=GF AC   PF08579.6
#=GF DE   Mitochondrial ribonuclease P subunit (RPM2)
#=GF AU   Mistry J, Wood V
#=GF SE   manual
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.50;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1409716
#=GF RT   A 105-kDa protein is required for yeast mitochondrial RNase P
#=GF RT   activity. 
#=GF RA   Morales MJ, Dang YL, Lou YC, Sulo P, Martin NC; 
#=GF RL   Proc Natl Acad Sci U S A. 1992;89:9875-9879.
#=GF RN   [2]
#=GF RM   16024791
#=GF RT   Rpm2p, a component of yeast mitochondrial RNase P, acts as a
#=GF RT   transcriptional activator in the nucleus. 
#=GF RA   Stribinskis V, Heyman HC, Ellis SR, Steffen MC, Martin NC; 
#=GF RL   Mol Cell Biol. 2005;25:6546-6558.
#=GF DR   INTERPRO; IPR013888;
#=GF CC   Ribonuclease P (RNase P) generates mature tRNA molecules by
#=GF CC   cleaving their 5' ends.  RPM2 is a protein subunit of the yeast
#=GF CC   mitochondrial RNase P.  It has the ability to act as
#=GF CC   transcriptional activator in the nucleus where it plays a role
#=GF CC   in defining the steady-state levels of mRNAs for some
#=GF CC   nucleus-encoded mitochondrial components [2].
#=GF SQ   46
#=GS Q75BC4_ASHGO/154-272  AC Q75BC4.2
#=GS C4QZW9_PICPG/169-288  AC C4QZW9.1
#=GS Q9C1F3_CANGB/166-285  AC Q9C1F3.1
#=GS G8ZNG9_TORDC/178-296  AC G8ZNG9.1
#=GS A5DWP5_LODEL/327-457  AC A5DWP5.1
#=GS G8BQX3_TETPH/270-391  AC G8BQX3.1
#=GS G8B5U2_CANPC/262-388  AC G8B5U2.1
#=GS H0GLQ3_9SACH/163-281  AC H0GLQ3.1
#=GS B9W7R6_CANDC/291-421  AC B9W7R6.1
#=GS C8ZEB4_YEAS8/163-281  AC C8ZEB4.1
#=GS G0VBZ9_NAUCC/169-285  AC G0VBZ9.1
#=GS D4B3F8_ARTBC/221-334  AC D4B3F8.1
#=GS C5DP63_ZYGRC/229-346  AC C5DP63.1
#=GS F2S3C9_TRIT1/222-335  AC F2S3C9.1
#=GS G8B8J5_CANPC/259-385  AC G8B8J5.1
#=GS G8YC00_PICSO/162-289  AC G8YC00.1
#=GS G8JSB0_ERECY/172-292  AC G8JSB0.1
#=GS G8YEF0_PICSO/161-289  AC G8YEF0.1
#=GS E7QIW2_YEASZ/163-281  AC E7QIW2.1
#=GS Q59MC4_CANAL/285-419  AC Q59MC4.1
#=GS H2B2G8_KAZAF/191-312  AC H2B2G8.1
#=GS F2QTS0_PICP7/169-288  AC F2QTS0.1
#=GS G2WJW6_YEASK/163-281  AC G2WJW6.1
#=GS Q59MB1_CANAL/285-419  AC Q59MB1.1
#=GS C5DIY7_LACTC/184-302  AC C5DIY7.1
#=GS C5MEK3_CANTT/288-417  AC C5MEK3.1
#=GS G3AYV1_CANTC/157-280  AC G3AYV1.1
#=GS A5DLV0_PICGU/167-302  AC A5DLV0.2
#=GS G3AFT0_SPAPN/246-371  AC G3AFT0.1
#=GS C7GV74_YEAS2/163-281  AC C7GV74.1
#=GS F2SR18_TRIRC/222-335  AC F2SR18.1
#=GS H8X0C3_9ASCO/258-387  AC H8X0C3.1
#=GS B3LLG7_YEAS1/163-281  AC B3LLG7.1
#=GS C4YEE5_CANAW/284-418  AC C4YEE5.1
#=GS Q6FQG6_CANGA/166-285  AC Q6FQG6.1
#=GS RPM2_YEAST/163-281    AC Q02773.1
#=GS G0WHF0_NAUDC/196-312  AC G0WHF0.1
#=GS Q6CRB1_KLULA/206-324  AC Q6CRB1.1
#=GS A6ZLX6_YEAS7/163-281  AC A6ZLX6.1
#=GS F2PK58_TRIEC/222-335  AC F2PK58.1
#=GS C4Y2H9_CLAL4/149-279  AC C4Y2H9.1
#=GS A3GG14_PICST/174-298  AC A3GG14.2
#=GS A7TIW8_VANPO/209-328  AC A7TIW8.1
#=GS E7R6F9_PICAD/161-253  AC E7R6F9.1
#=GS B6QAG0_PENMQ/178-289  AC B6QAG0.1
#=GS Q6BZ89_DEBHA/170-298  AC Q6BZ89.2
Q75BC4_ASHGO/154-272             ..........................DVRFQEDLPPWQ...LDREPCLN....EKTFLATS.IKEIKTCMEN....EDYNKVNCIYQALKRNGI-VPPVNTFEQVLCAIKLRDMDA.....DDPEGKMVQLLNCYQDL.V...SNK.......LKPTTEIYTIVIGSLLERAA-t.
C4QZW9_PICPG/169-288             .....................gkksa------QIEELE...ETAEPQQEe.qsSTSGMEDE.IRMIHSFVSQ....KRYNEVFALYLRAKAKEIKL-DRSVYTMVLRAITKRETN-.....ETVEEKLTHLLNVYSDL.L...TSN.......IKPNKDIYELVIGSLLAGA--tk
Q9C1F3_CANGB/166-285             ..........................DLLELEKEYNWE...KDTDDDLN....PQTYLSTH.IDQINKHFVK....GNYNIINALYKSLKRNGIAIQDREVLTKVLISLARREMDD.....LDIDNKVFELLSCYQDI.I...TNR.......IKPNLEIYNIVLETLFKSSI-v.
G8ZNG9_TORDC/178-296             .......................eqv---IEQVVSPWE...EDTEPCLN....HETFLATQ.VAEIERCYAK....GDYNMINSLYQALKRNGI-VPPVNVYFKVLESLAKRDLDK.....DDLDYKMSELLTCYQDM.I...VSK.......LKPSDEIYNTVLGCLFKGSI-l.
A5DWP5_LODEL/327-457             .............andtsnvkkvsda----------DE...TDHYNEF-....NDHFLTTQ.TRLLRNAYEQysspQDLDVIYPIYQSIKRNGLTLPEVDLYDIVLRSIANRKLDSel.eiTAIENKLTNLLTVYQDL.L...CVA......gLKPSLETYTIVVTSLLDASL-a.
G8BQX3_TETPH/270-391             .................nhdneqnie--------DNWP..wEENESYLN....KETFLDSH.SQKIKENFNN....ENYEIILPLYQSIKRNDC-IPSLETYYQIIFSIINRKFDS.....NDINYKMYQILSIYEDI.I..iKHK.......MKPTEDIYNLILQSLFTSSIK..
G8B5U2_CANPC/262-388             .........................q-LTKTSQKSPTK...VGVEDSF-....ENGFLESQ.IANITNAFENygdkKDLDMIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L...YAN.......LKPDNETYNLVVNAMLDSTL-k.
H0GLQ3_9SACH/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
B9W7R6_CANDC/291-421             ...................ktvaeqq--------KQSQ...PPSQENITvdtfEQDFLASK.VSKIVSVFDTysspDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILHRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAG.......IKPNKETYNIVVTALLNGSLQ..
C8ZEB4_YEAS8/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
G0VBZ9_NAUCC/169-285             .......................tps-----ENDFPWE...KDTELSLN....KNTFLNTH.INEITKCYQN....GDLNKINSLYHSLKRNNV-IPPMGIYEVVLNSIAERKLDE.....NDLDNKMFEMLTCYQDI.L...SNK.......MKPSAIVYNILLNSLFKSSI-l.
D4B3F8_ARTBC/221-334             ........iqesivsprtpvndttpy------------...--------....EKKQAESR.SNAIVELAKD....GAHAQVPAAFESLLRDGI-KPTASAYNALLEAAIRLHPE-.....--AHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d.
C5DP63_ZYGRC/229-346             .......................skq----RDSMSPWE...EDKEPCLN....KDTFLRTH.TDQINKCYEN....GDLNSINSLYQALKRNDI-IPPLKVYEQILDSVARRQFDN.....DDLDYKIAELLTCYQDL.I...MNR.......LKPSDRIYNTVLECLFKASI-a.
F2S3C9_TRIT1/222-335             ...........vqesivsprtpvndi------------...-----SLY....EKKQAESR.SNAIVELAKD....GAHAKVPAAFESLLRDGV-KPTASAYNALLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d.
G8B8J5_CANPC/259-385             .........................q-LTKTSQKSPTK...VGVEDSF-....ENGFLESQ.IANITNAFENygdkKDLDIIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L...YAN.......LKPDDETYNLVVNAMLDSTL-k.
G8YC00_PICSO/162-289             ...................gtlknds--------TEDP...EDTSNEF-....ETRFLKTQ.TDNILEIYKSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIATRTLDNdi.nmGAIEARLTNIMTVYQHL.L...DEIs....psLRPSSTTYEIVLRELFKGAA-e.
G8JSB0_ERECY/172-292             ..................slrleeqy------YVSAWE...PDTESCLN....SETFLQTN.IKEIERCVQI....KDYNRVNAIYQALKRNGI-LPPVETFAQIMRSIHLRELDS.....DDLDNKMFQLLSCYQDL.I...SNK.......LKPTDEIYTIIIGALLQGSIT..
G8YEF0_PICSO/161-289             ...................igalknd-------QTEDP...EDTSNEF-....ETRFLKTQ.TDNILEIYNSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIAARTLDNdi.smGAIEARLTNIMTVYQHL.L...DEIs....psLRPSSTTYEIVLRELFKGA--te
E7QIW2_YEASZ/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
Q59MC4_CANAL/285-419             ..........................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAG.......IKPNKETYNIVVTALLKGSLQ..
H2B2G8_KAZAF/191-312             ......................qrki----QDDEDPWE...KDTDESLN....KTTFLQTH.IDQINNCYRI....EDYNKINSLYQSLKRNNI-VPPIEIYEKIFDSFNKRNFDQn..tnLLINEKMYQLLNCYQDL.I...NSK.......LKPTTTIYNSLLEQIFKNSI-i.
F2QTS0_PICP7/169-288             .....................gkksa------QIEELE...ETAEPQQEe.qsSTSGMEDE.IRMIHSFVSQ....KRYNEVFALYLRAKAKEIKL-DRSVYTMVLRAITKRETN-.....ETVEEKLTHLLNVYSDL.L...TSN.......IKPNKDIYELVIGSLLAGA--tk
G2WJW6_YEASK/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
Q59MB1_CANAL/285-419             ..........................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAS.......IKPNKETYNIVVTALLKGSLQ..
C5DIY7_LACTC/184-302             ........................pv--SANSQASPWE...PDTEETLN....PETFLQTQ.VAHIKHCFAV....GDYNKINALYQALVRNEI-VPPVEIYATVIESVCMRDLDN.....DNVDNRMFQLLNCYQDL.I...NNK.......LKPTEKIYSLVIGSLLKGSI-l.
C5MEK3_CANTT/288-417             ..............qstnvpevavee----------PA...AQKVDTF-....EVDFLATQ.VSNITSAFDNhkcpEDLNIIYPLYQAVKRNDLTLPSIDLYNIVLKSILQRSLNNtelelSAIEERLTTLLTVYQDI.L...SIG.......LKPNKETYNLIVNALLDGSLQ..
G3AYV1_CANTC/157-280             ........vtsvedahksepleyddf------------...--------....-ESFKTTQ.ISKINSLFEE....EDYNLIFPIYQSLKRNHMGLGSTELYNKVLSSLLLREFDNsm.qlEDIEIRLTNLLTVYQDF.LffaNEQ.......MKPDFSTYNIVIGGLLKGSL-d.
A5DLV0_PICGU/167-302             .............qfqekspeepqks-----------E...PEADEAI-....-SASLATNlVNQIVTVFANhqspQDLNVIYPLYQSLKRNEITLPSIAEYNMVLKAIADRALNSev.tnEDIESKLTTLLTVYQDI.L...QASvhtksdsLKPNEETFNIILRELFQGA--nk
G3AFT0_SPAPN/246-371             ................efvknihttq-----------S...KPVEPQF-....EAHFLQTQ.IDNITSAFNNfkqpQDLNIIYPLYQAIKRNELALPTVELYNIVLESIVRRSLDGes.tlQAIESKLTNLLTVYQDI.L...STG.......LKPNKSTYNLVVDSLLDSSL-k.
C7GV74_YEAS2/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
F2SR18_TRIRC/222-335             ...........vqesivsprtpvndi------------...-----SLY....EKKQAESR.SNAIVDLAKD....GAHAQVPAAFESLLRDGI-KPTASAYNVLLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d.
H8X0C3_9ASCO/258-387             ..............ltktsqtaspid----------VK...EEHDEDAF....ENSFLQTQ.ITNINNAFEKqadkKELNIIYPLYQAIKRNELALPTVELYNIVLKSIIDRPIDNev.nvGAIERKLTNLLTVYQDI.L...YAN.......LKPDNETYNLVVNAMLDSTI-k.
B3LLG7_YEAS1/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
C4YEE5_CANAW/284-418             ..........................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAG.......IKPNKETYNIVVTALLKGSLQ..
Q6FQG6_CANGA/166-285             ..........................DLLELEKEYNWE...KDTDDDLN....PQTYLSTH.IDQINKHFVK....GNYNIINALYKSLKRNGIAIQDREVLTKVLISLARREMDD.....LDIDNKVFELLSCYQDI.I...TNR.......IKPNLEIYNIVLETLFKSSI-v.
RPM2_YEAST/163-281               .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
G0WHF0_NAUDC/196-312             .....................thips-------SSPWE...IDTETSLN....PKTYLSTH.INEINKAYLM....QDFNKINSLYHSLKRNNI-IPPIETFEKILDSISKRLMDK.....FDLDNKMFEMLSCYQDI.I...NNK.......LKPSNAIYNILLSSLFKNSI-m.
Q6CRB1_KLULA/206-324             ..........................DVRLDDSIPAWE...TDLEPCLN....KEAFLETQ.SKLIEDCMKN....KNYNQVNAIYKSLIRNEI-VPPLSLFEQVLTSICRRDLDQ.....NNIDNQMFELLNCYQDI.I...QNK.......LKPSAEIYHLVVGSLLSGSIR..
A6ZLX6_YEAS7/163-281             .........................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l.
F2PK58_TRIEC/222-335             ...........vqesivsprtpvndi------------...-----SLY....EKKQAESR.SNAIVELAKD....GAHAKVPAAFESLLRDGV-KPTASAYNALLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d.
C4Y2H9_CLAL4/149-279             .................tsskvpsen----------IP...EKEEDDF-....ESSFQKSQ.VDKIVNTFIShecpEDLNVIYPLYQGLKRNHIPLPSVHEYNIVLKSISMRELDSqc.tiSAIESKLTSLLTVYEDL.L...AVCsr..daaFKPNTETYNVILADIFKGAL-e.
A3GG14_PICST/174-298             ......................kita------ETPSLR...TDTDGSF-....ESNFLHNQ.IAAITSTYSSytdaSELNIIYPLYQSLKRNDLTLPSIQLYNIVLSSIEKRALDSef.tlEAIENKLTNLLTVYQDI.L...SSG.......NKPDTETYNLIIRNLLQGNL-d.
A7TIW8_VANPO/209-328             .....................tinni-----NNDFPWE...KDNEESLN....KDTYLKAH.MDSIDKAFIK....KDYNIINALYQSLKRNDC-VPSIETYYKILYSIAHRDLDS.....DDINYKMFQILSCYEDIiI...KNK.......LKPTDEIYSVLLENLFKGSI-i.
E7R6F9_PICAD/161-253             ...........livddvaredsgrkt------------...--------....--------.----------....---REVLAVYFNLRGKGL-VPTTALYNKVLRSIPQRTDTG.....ESAEDKLTHLLNVYSDM.L...SNN.......LKPSDETYELVVGPLLKGA--qn
B6QAG0_PENMQ/178-289             denavdstaheltidvnaeksivasg------------...--------....--------.--RVVQLAVE....EKYAEIPAAFEAILRDGV-TPSVEAYNSLLQAAIKLHTDS.....YH---AVPKALDVYSDM.L...RRR.......VIPNQETYKTLIAVLVSRAV-e.
Q6BZ89_DEBHA/170-298             ........................qi---NETAYEELI...EDKEEDF-....ESNLLHTQ.ISNIEAIYAKq.gpTELNLIYPLYQTLKRNCLQLPSIHLYNIVLKSIVERKLDNdartfENIESRLTNLLTVYQDI.L...VGSs....eqVKPNKETYEIVLNELLRGSLQ..
#=GC seq_cons                    .........................t..........hp...p-s-ssl.....cpsaLpTp.lspIspsapp....pchNhI.sLYQuLKRNsl.lPsl-lYshVLcSlscRplDs.....ssl-sKlspLLTsYQDl.l...ssp.......lKPscEhYNIVltuLhcGSl...
//
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