#=GF ID RPM2
#=GF AC PF08579.15
#=GF DE Mitochondrial ribonuclease P subunit (RPM2)
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Wood V;0000-0001-6330-7526
#=GF SE manual
#=GF GA 27.60 27.60;
#=GF TC 27.60 27.60;
#=GF NC 27.50 27.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0020
#=GF RN [1]
#=GF RM 1409716
#=GF RT A 105-kDa protein is required for yeast mitochondrial RNase P
#=GF RT activity.
#=GF RA Morales MJ, Dang YL, Lou YC, Sulo P, Martin NC;
#=GF RL Proc Natl Acad Sci U S A. 1992;89:9875-9879.
#=GF RN [2]
#=GF RM 16024791
#=GF RT Rpm2p, a component of yeast mitochondrial RNase P, acts as a
#=GF RT transcriptional activator in the nucleus.
#=GF RA Stribinskis V, Heyman HC, Ellis SR, Steffen MC, Martin NC;
#=GF RL Mol Cell Biol. 2005;25:6546-6558.
#=GF DR INTERPRO; IPR013888;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC Ribonuclease P (RNase P) generates mature tRNA molecules by
#=GF CC cleaving their 5' ends. RPM2 is a protein subunit of the yeast
#=GF CC mitochondrial RNase P. It has the ability to act as
#=GF CC transcriptional activator in the nucleus where it plays a role
#=GF CC in defining the steady-state levels of mRNAs for some
#=GF CC nucleus-encoded mitochondrial components [2].
#=GF SQ 87
#=GS A0A1D2VNH4_9ASCO/323-435 AC A0A1D2VNH4.1
#=GS J7RB45_KAZNA/187-305 AC J7RB45.1
#=GS RPM2_YEAST/163-281 AC Q02773.1
#=GS Q6FQG6_CANGA/166-285 AC Q6FQG6.1
#=GS A0A1E3QCS0_LIPST/280-385 AC A0A1E3QCS0.1
#=GS A0A4T0WX46_9ASCO/175-290 AC A0A4T0WX46.1
#=GS Q6CRB1_KLULA/206-324 AC Q6CRB1.1
#=GS G8YC00_PICSO/163-289 AC G8YC00.1
#=GS A0A433DHY7_9FUNG/123-226 AC A0A433DHY7.1
#=GS G8YEF0_PICSO/163-289 AC G8YEF0.1
#=GS A0A8H7GUR3_9ASCO/1-83 AC A0A8H7GUR3.1
#=GS A0A7H8QYN3_9EURO/181-291 AC A0A7H8QYN3.1
#=GS A3GG14_PICST/174-298 AC A3GG14.2
#=GS A0A1Q2YE47_9ASCO/219-338 AC A0A1Q2YE47.1
#=GS A0A232M4U2_9EURO/205-317 AC A0A232M4U2.1
#=GS A0A1B7TAS4_9ASCO/331-451 AC A0A1B7TAS4.1
#=GS A0A367XS28_9ASCO/297-421 AC A0A367XS28.1
#=GS G3AFT0_SPAPN/248-371 AC G3AFT0.1
#=GS A0A1S7HS17_9SACH/192-309 AC A0A1S7HS17.1
#=GS W1QF10_OGAPD/187-302 AC W1QF10.1
#=GS A0A2H3IQG5_9EURO/192-289 AC A0A2H3IQG5.1
#=GS A0A1A0H7J9_9ASCO/162-290 AC A0A1A0H7J9.1
#=GS H2B2G8_KAZAF/191-312 AC H2B2G8.1
#=GS A0A1V2L1P5_CYBFA/198-312 AC A0A1V2L1P5.1
#=GS A0A512UDL1_9ASCO/188-313 AC A0A512UDL1.1
#=GS A0A2H0ZFN9_CANAR/162-292 AC A0A2H0ZFN9.1
#=GS A0A1E3NHR9_9ASCO/219-337 AC A0A1E3NHR9.1
#=GS A0A875RQG5_EENNA/205-322 AC A0A875RQG5.1
#=GS A0A0C7MJW9_9SACH/212-330 AC A0A0C7MJW9.1
#=GS A0A1E4T6V4_9ASCO/1-81 AC A0A1E4T6V4.1
#=GS A0A642UCB0_DIURU/144-257 AC A0A642UCB0.1
#=GS A0A7H9HWZ4_9SACH/177-296 AC A0A7H9HWZ4.1
#=GS A0A0U1M506_TALIS/184-291 AC A0A0U1M506.1
#=GS A0A1E4RF32_9ASCO/171-304 AC A0A1E4RF32.1
#=GS A0A3N4M6H7_9PEZI/163-259 AC A0A3N4M6H7.1
#=GS G8B8J5_CANPC/259-385 AC G8B8J5.1
#=GS A0A1E3P2L2_WICAA/215-329 AC A0A1E3P2L2.1
#=GS A0A1E4TQJ3_PACTA/166-287 AC A0A1E4TQJ3.1
#=GS A0A4C2E2G2_9SACH/230-347 AC A0A4C2E2G2.1
#=GS A0A2P7YNY0_9ASCO/167-294 AC A0A2P7YNY0.1
#=GS G0VBZ9_NAUCC/169-285 AC G0VBZ9.1
#=GS I2K2W3_DEKBR/228-348 AC I2K2W3.1
#=GS K0KVB8_WICCF/205-318 AC K0KVB8.1
#=GS G8ZNG9_TORDC/179-296 AC G8ZNG9.1
#=GS C4Y2H9_CLAL4/151-279 AC C4Y2H9.1
#=GS A0A1E4RZ93_CYBJN/199-305 AC A0A1E4RZ93.1
#=GS A0A7H9B0S4_ZYGMR/213-327 AC A0A7H9B0S4.1
#=GS A0A1E5R9W9_HANUV/320-440 AC A0A1E5R9W9.1
#=GS A0A1X7R8Q5_9SACH/168-286 AC A0A1X7R8Q5.1
#=GS A0A2U9R9C0_PICKU/194-332 AC A0A2U9R9C0.1
#=GS A0A1G4M912_LACFM/174-291 AC A0A1G4M912.1
#=GS C4QZW9_KOMPG/169-288 AC C4QZW9.1
#=GS Q6BZ89_DEBHA/170-298 AC Q6BZ89.2
#=GS G8JSB0_ERECY/172-292 AC G8JSB0.1
#=GS G3AYV1_CANTC/159-280 AC G3AYV1.1
#=GS A0A1D8PDF0_CANAL/296-419 AC A0A1D8PDF0.1
#=GS A0A1E3QKA1_9ASCO/241-369 AC A0A1E3QKA1.1
#=GS A0A421JRR4_9ASCO/253-378 AC A0A421JRR4.1
#=GS A0A225AJW1_9EURO/185-295 AC A0A225AJW1.1
#=GS A0A4P6XIG7_9ASCO/186-315 AC A0A4P6XIG7.1
#=GS A0A367Y3K8_9ASCO/293-418 AC A0A367Y3K8.1
#=GS A0A448YEV7_BRENA/225-334 AC A0A448YEV7.1
#=GS A5DWP5_LODEL/329-457 AC A5DWP5.1
#=GS A0A1L0DEP8_9ASCO/183-315 AC A0A1L0DEP8.1
#=GS A7TIW8_VANPO/209-328 AC A7TIW8.1
#=GS A0A4P9ZHF7_9ASCO/166-296 AC A0A4P9ZHF7.1
#=GS A0A1E4SN51_9ASCO/155-276 AC A0A1E4SN51.1
#=GS B6QAG0_TALMQ/181-289 AC B6QAG0.1
#=GS A0A1E3PSL4_9ASCO/341-443 AC A0A1E3PSL4.1
#=GS A0A376B6B6_9ASCO/209-328 AC A0A376B6B6.1
#=GS I2H228_TETBL/101-218 AC I2H228.1
#=GS Q75BC4_ASHGO/154-272 AC Q75BC4.2
#=GS G8BQX3_TETPH/272-391 AC G8BQX3.1
#=GS C5MEK3_CANTT/294-417 AC C5MEK3.1
#=GS A5DLV0_PICGU/167-302 AC A5DLV0.2
#=GS A0A2V1B1V1_9ASCO/165-295 AC A0A2V1B1V1.1
#=GS G8B5U2_CANPC/262-388 AC G8B5U2.1
#=GS A0A1G4JSW1_9SACH/186-302 AC A0A1G4JSW1.1
#=GS A0A364KWT5_9EURO/179-289 AC A0A364KWT5.1
#=GS G0WHF0_NAUDC/196-312 AC G0WHF0.1
#=GS A0A421J6P1_9ASCO/165-299 AC A0A421J6P1.1
#=GS M3IMX3_CANMX/292-416 AC M3IMX3.1
#=GS A0A1G4J8S0_9SACH/217-335 AC A0A1G4J8S0.1
#=GS A0A8J5USJ0_9ASCO/264-391 AC A0A8J5USJ0.1
#=GS A0A8H6BW02_CANAX/274-397 AC A0A8H6BW02.1
#=GS A0A1E5RYS5_9ASCO/445-564 AC A0A1E5RYS5.1
#=GS C5DIY7_LACTC/184-302 AC C5DIY7.1
A0A1D2VNH4_9ASCO/323-435 .............................pkeikfsnsl-------------.-------..DKSF...HSS.....L.INEINTS.IQN....SNYLKIYPIYQVIKRNNL.PISLDLYNLVLQSLIKRN.LT..S......ET....IEEKLTNLLNVYTDL.I....S....SInn...fdLKPNSKTYELVLNGLLSGSL-n..
J7RB45_KAZNA/187-305 ....................................dli-----DNTSPWEQ.DTETGLN..KDTY...LQT.....H.LRQIDEC.YKT....GDYNMINSLYQSLRRNDI.VPPLQTYEIIFHSFNKRP.FD..D......NNl..nLNEKMFQLLNCYQDL.L....K....NK.......LKPTTTIYNILLFQIFKNSI-v..
RPM2_YEAST/163-281 ......................................s-LLKDENAPVWKE.DTEPCLN..KSTY...LQT.....H.IDEINRC.YEQ....KNYNKINSLYQSLKRNDI.VPPLEIFTKVLDSLCKRP.LD..N......ND....LDNKMYELLTCYQDM.I....N....NR.......LKPPDEIYNIVLLSLFKGSI-l..
Q6FQG6_CANGA/166-285 .......................................DLLELEKEYNWEK.DTDDDLN..PQTY...LST.....H.IDQINKH.FVK....GNYNIINALYKSLKRNGIaIQDREVLTKVLISLARRE.MD..D......LD....IDNKVFELLSCYQDI.I....T....NR.......IKPNLEIYNIVLETLFKSSI-v..
A0A1E3QCS0_LIPST/280-385 .....................aalastpdtalsasesel-------------.-------..----...---.....-.--VIQNL.FTT....KNFTGVLTHYELMRQNKT.VPTLASFNQILISIASGE.QV..T......-P....STGRESYLLEVYADM.L....Q....HH.......IVPDVATYSTVILTLVQR---fmn
A0A4T0WX46_9ASCO/175-290 ................................ddlkklk-------INNLPT.EKEIDYN..D--P...IQV.....Q.NLLVDQF.NSQ....GKFNEILPLYNRMRNNQL.IPDLNLYNKILNSIQFRK.TD..-......EN....LETKLSHLLNIYSDM.L....S....NN.......IKPSLETYNIVINQLINGSL-n..
Q6CRB1_KLULA/206-324 .......................................DVRLDDSIPAWET.DLEPCLN..KEAF...LET.....Q.SKLIEDC.MKN....KNYNQVNAIYKSLIRNEI.VPPLSLFEQVLTSICRRD.LD..Q......NN....IDNQMFELLNCYQDI.I....Q....NK.......LKPSAEIYHLVVGSLLSGSIR...
G8YC00_PICSO/163-289 ................................tlkndst---------EDPE.DTSNEF-..ETRF...LKT.....Q.TDNILEI.YKSg.drNKLNLIYPLYQAIVRNNItIPSVDIYNVVLDSIATRT.LD..Ndi..nmGA....IEARLTNIMTVYQHL.L....D....EIs....psLRPSSTTYEIVLRELFKGAA-e..
A0A433DHY7_9FUNG/123-226 ............tnkkptaeaanektrefnniilsqkrs-------------.-------..----...---.....-.-------.---....YDLRGVVSTFESMKQQGV.VPSQHTYNLVLDAYASLR.KD..G......--....--TPLVNLLHVYDEM.I....Q....AE.......VQPNVFTYTILIIALCRR---dae
G8YEF0_PICSO/163-289 .................................alkndq--------TEDPE.DTSNEF-..ETRF...LKT.....Q.TDNILEI.YNSg.drNKLNLIYPLYQAIVRNNItIPSVDIYNVVLDSIAART.LD..Ndi..smGA....IEARLTNIMTVYQHL.L....D....EIs....psLRPSSTTYEIVLRELFKGA--te.
A0A8H7GUR3_9ASCO/1-83 .......................................-------------.-------..----...---.....-.-------.---....--------MYQSLKRNDIlLPSIEEYNMVLKSIAMRS.LD..Get..tlTA....MESKLTCLLTIYQDI.L....S....AAli..hahCRPNAETFLIVLGSLFKGS--kd.
A0A7H8QYN3_9EURO/181-291 ................nvaeseaaveqlsdlqieqshse-------------.-------..----...---.....-.SLRIVQL.AVA....EKYVEIPAAFEELVRAGL.TPSVEAYNALLVAAIKLH.AD..S......S-....--HAVPKALDVYSDM.L....R....RR.......VMPNEETYKTLIAILVSRA--fe.
A3GG14_PICST/174-298 ...................................kita------ETPSLRT.DTDGSF-..ESNF...LHN.....Q.IAAITST.YSSytdaSELNIIYPLYQSLKRNDLtLPSIQLYNIVLSSIEKRA.LD..Sef..tlEA....IENKLTNLLTVYQDI.L....S....SG.......NKPDTETYNLIIRNLLQGNL-d..
A0A1Q2YE47_9ASCO/219-338 ........................qqlndqanyrfesvd-------------.---DAL-..-DTF...LYTdpvksQ.EVIIDSM.MSL....GKFNEVLPVFIRMRNNEI.IPSIEIYNKVLKSIQLRE.TD..E......-T....LEARLTHLLNTYSDM.L....S....NN.......LKPNNTTYELIIDNLVKGSIK...
A0A232M4U2_9EURO/205-317 ................dvtteastletaqtadttaeksq-------------.-------..----...--L.....S.SDRIVQL.ASA....QKYVEIPAAFEGLLKEGL.LPTVEAYNALLAAAIELH.LD..S......AQ....A---VPKALDIYSDM.I....R....RR.......VMPNEDTYKTLVSALVSRAL-e..
A0A1B7TAS4_9ASCO/331-451 .................................vseevy----EKTKQIWPA.DGDKGFN..SLKF...KET.....L.TIQIDNA.FSQ....KDYNKIYSLYLAMKRNDC.VPSVETFDKIIKSLCLRS.ED..N......TN....LDERMFNILTCYQDL.I....G....LK.......IKPLASTYHDIILALLNGSIT...
A0A367XS28_9ASCO/297-421 ...........................ttevvvevpnqk-------------.--VDTF-..EKDF...LAT.....Q.ISNITSA.FNNhtcpEDLNIIYPLYQAVKRNNLaLPTIDLYNIVLKSILERG.LN..Nta.ldlCS....IEERLTTLLTVYQDI.L....N....SG.......MKPDKETYNLVVNALLDGSLQ...
G3AFT0_SPAPN/248-371 .............................vknihttqsk-------------.PVEPQF-..EAHF...LQT.....Q.IDNITSA.FNNfkqpQDLNIIYPLYQAIKRNELaLPTVELYNIVLESIVRRS.LD..Ges..tlQA....IESKLTNLLTVYQDI.L....S....TG.......LKPNKSTYNLVVDSLLDSSL-k..
A0A1S7HS17_9SACH/192-309 ....................................qre----EQFSSPWEE.DTEPCLN..KDTF...LQT.....H.VDHIRRC.QEL....GDLNKINSLYQSLKRNDI.VPPVDVYATILDSIARRQ.FD..K......DD....LDYKVSELLTCYQDM.I....T....NK.......LKPSDEVYNTVLGCLFHSSV-i..
W1QF10_OGAPD/187-302 ..............................getgetaek------------S.EQAKEVD..PATP...LSV.....H.ERLIDEL.LSS....NRPSEVLAVYFNLRGKGL.VPTTALYNKVLRSIPQRT.DT..G......ES....AEDKLTHLLNVYSDM.L....S....NN.......LKPSDETYELVVGPLLKGA--qn.
A0A2H3IQG5_9EURO/192-289 ........................dvtaeksivasgrvv-------------.-------..----...---.....-.-----QL.AVE....EKYAEIPAAFEAILRDGV.TPSVEAYNSLLQAAIKLH.TD..S......YH....---AVPKALDVYSDM.L....R....RR.......VMPNQETYKTLIAALVSRAV-e..
A0A1A0H7J9_9ASCO/162-290 .......................knspdahesgeysepf-------------.-------..EEGF...ART.....Q.IAQIMQA.YENysspDDLNIIYPLYQSLKRNGIlLPSIDEYNIILKSIVMRA.LD..S......EDtlsaTESRLTCLLTVYQDV.L....I....ACqs..tptCHPNRETYQIVLRSIFDGS--rk.
H2B2G8_KAZAF/191-312 ....................................qrk---IQDDEDPWEK.DTDESLN..KTTF...LQT.....H.IDQINNC.YRI....EDYNKINSLYQSLKRNNI.VPPIEIYEKIFDSFNKRN.FD..Q......NTn.llINEKMYQLLNCYQDL.I....N....SK.......LKPTTTIYNSLLEQIFKNSI-i..
A0A1V2L1P5_CYBFA/198-312 ...........................ettkyfspgeie-------------.--EVELS..DRTF...LLS.....Q.TKAINSA.YQS....GQFEKVNSLYMAIKRNDL.VPSREVYSLVLSSIVRRT.ID..D......-S....LDEKLSTMLNVYQDL.I....S....NK.......IKPDVEIYSTVISALLEGAV-k..
A0A512UDL1_9ASCO/188-313 .................................isseqv------------A.DEEMPF-..EESF...LKS.....Q.LGQIVHT.FENhespEDLNIIYPIYQSLKRNNIiLPSIKEYNIVLKSISMRS.LD..Sea..slTE....TESRLTCLLTVYQDI.L....A....ACqe..nanCHPNSETYHTVLHSIFRSS--ra.
A0A2H0ZFN9_CANAR/162-292 ...........................sqpkieelpvep-------------.-TEEQPF..EDSF...QKT.....Q.AENIMRI.YNNhtssEELDVIYPLYQSLKRNDIpLPSILHYNIVLESILLRS.LD..Nqt.lslTA....IESRLTNLLTVYQDV.L....RfcskSS.......LKPDSTTYDLVLKGVFDGCV-d..
A0A1E3NHR9_9ASCO/219-337 .........................qlndqanrtfesid-------------.---DAL-..-DTF...LYTdpvksQ.EVIVDSM.MSM....GKFNEVLPVFIRMRNNEI.IPSIEIYNKVLKSIQLRD.TD..E......-T....LETRLTHLLNTYSDM.L....S....NN.......IKPNNATYELIIDNLVKGSIK...
A0A875RQG5_EENNA/205-322 ................klelkkhsnveveiekevvdgqv-------------.-------..---A...EYT.....Q.EQVIDKM.MSL....GKNNEVLAVYLRLRGNHV.VPCIDTYNKILKSISLRD.TD..E......T-....SEQKLTHLLNTYSDM.L....S....NN.......IKPNEETYELVIEQLLGGSL-a..
A0A0C7MJW9_9SACH/212-330 ..................................dkhkg-----TPIPTWEP.DNEESLN..PETF...LET.....Q.TNYIKTS.YEK....RDYNSINASFQSLIRNNI.IPPLELYALVIKSVCNRD.LD..N......DN....VDNRMFQLLNCYQSL.I....D....NK.......MKPTEEIYNEVIGSLLKGSI-a..
A0A1E4T6V4_9ASCO/1-81 .......................................-------------.-------..----...---.....-.-------.---....KKYNEILPIYSRIKNNNL.NPSLSIYNKVISSIPMRN.IT..D......ES....IEDNLSLLLTVYSDM.L....S....NN.......IKPSNETYQMVLDSLFKGSL-k..
A0A642UCB0_DIURU/144-257 .....................epipsatpkqessqsidp-------------.-------..---Y...LSS.....Q.LESLKTC.---....-EPNLVYPIYQSIRRNDMtLPSVEDYNFVLRSIATRP.CD..Ssd..dvND....VERKLTTLMTVYQDM.L....T....-V.......FKPTSETYNLVLAELVRGAI-r..
A0A7H9HWZ4_9SACH/177-296 ...................................dvtv---REEVKSPWEE.DTEPCLN..VETF...LDT.....H.ITEINRC.YEK....GDFNMINSLYQALKRNGI.VPPLETYSKVLESLSRRD.LD..K......DD....LDYKMSELLTCYQDM.I....V....NK.......LKPSDEIYNTVLGCLFKGSI-l..
A0A0U1M506_TALIS/184-291 ......................eseaaaeqpddvfiers-------------.-------..----...-HS.....E.SSRIVQL.AVA....EKYVEIPAAFEELVRAGL.TPSVEAYNALLVAAIKLH.AD..S......A-....--HAVPKALDVYSDM.L....R....RR.......VMPNEETYKTLIAVLVSRAL-e..
A0A1E4RF32_9ASCO/171-304 .................................iqeqle------EIEEIELsNPEPSF-..ESQF...LTT.....Q.VNQIINI.YNNskssSDLNIIYPLYQSLKRNDLpCSSIDVYNIILASINERS.LD..Ndd.ssiQA....IESRLTNLLTVYQDI.L....I....SAns..napLKPNNATFSIVLQGIFKGSL-d..
A0A3N4M6H7_9PEZI/163-259 ..............................mspvdqfna-------------.-------..----...---.....-.--ELEKL.KRQ....GRFKDITIQFQFMVQSGL.EPNTETFNCLLS-AKAQL.MR..L......GV....LDNRISYLLDVYKDL.L....H....RK.......LVPSTKTYSILLTSLVKCA--hs.
G8B8J5_CANPC/259-385 .................................qltkts------QKSPTKV.GVEDSF-..ENGF...LES.....Q.IANITNA.FENygdkKDLDIIYPLYQSIKRNGLtLPSVELYNMVLKSIIDRF.ID..Nev..eiGA....IERKLTNLLTVYQDI.L....Y....AN.......LKPDDETYNLVVNAMLDSTL-k..
A0A1E3P2L2_WICAA/215-329 .........................kffqpittekipdi-------------.----ELS..DATF...LRE.....Q.SERIYVA.YDQ....HRYRRIHSHYMAIKRNNI.VPSREIYTIVLSSISKRS.ID..D......-T....LDDKLSTMLNVYQDL.I....Q....HK.......IKPDLAIYSVVINDLLEGSIK...
A0A1E4TQJ3_PACTA/166-287 .......................qineeengnfskieif-------------.--EDDLHgpDKDF...LKE.....Q.YKIIYNL.ERQ....NKNNEIFAIYLRIKSKNI.IPNLEILNMVLKSIPLRI.HT..F......ES....TEENLTNLLDVYSDM.L....S....WG.......IKPNQTTFKLVILPLLDGSI-k..
A0A4C2E2G2_9SACH/230-347 .....................................sr---QHDPVSPWEE.DKEPCLN..KDTF...LKT.....H.IGQINKC.YEN....GDLNAINSFYQALKRNDI.VPPLKVYEQILDSLARRP.FD..S......DD....LDYKIAELLTCYQDL.I....V....NR.......LKPSDKIYNTVLECLFKGSI-a..
A0A2P7YNY0_9ASCO/167-294 ........................ieevveefggeevpf-------------.-------..AESF...RKS.....Q.CDEITKV.YNThaspEDLDIIYPLYQALKRNDIpLPTIELYNIVLESILSRA.LD..Sdk.sslAS....IESKLTNLLTVYQDV.L....HlcssTS.......LRPDSTTYNLVLKGIFEGCV-e..
G0VBZ9_NAUCC/169-285 ....................................tps-----ENDFPWEK.DTELSLN..KNTF...LNT.....H.INEITKC.YQN....GDLNKINSLYHSLKRNNV.IPPMGIYEVVLNSIAERK.LD..E......ND....LDNKMFEMLTCYQDI.L....S....NK.......MKPSAIVYNILLNSLFKSSI-l..
I2K2W3_DEKBR/228-348 ...........................edeeekevadnv-------EQKVNA.QTAGDFS..PETY...SDE.....E.I--IDNM.MAV....GKVNEVLSVYLRLRSNNI.VPSIKVYNKVMESIRLRE.TD..E......-T....MEQKLTNLLNVYSDM.L....S....NS.......IKPDNISYELVIKSLVEGSL-h..
K0KVB8_WICCF/205-318 ...........................lqspdqynelip-------------.---EEQN..DETF...LTQ.....Q.TNQILEA.NDS....YQYEKIHSLYMAIKRNNI.IPSRELYAIVLSSIVERK.ID..D......-S....LDDKLSTLLNVYQDL.V....S....NK.......IKPDSQIYSIVINKLLSASI-e..
G8ZNG9_TORDC/179-296 ...................................qvie-----QVVSPWEE.DTEPCLN..HETF...LAT.....Q.VAEIERC.YAK....GDYNMINSLYQALKRNGI.VPPVNVYFKVLESLAKRD.LD..K......DD....LDYKMSELLTCYQDM.I....V....SK.......LKPSDEIYNTVLGCLFKGSI-l..
C4Y2H9_CLAL4/151-279 ................................skvpsen----------IPE.KEEDDF-..ESSF...QKS.....Q.VDKIVNT.FIShecpEDLNVIYPLYQGLKRNHIpLPSVHEYNIVLKSISMRE.LD..Sqc..tiSA....IESKLTSLLTVYEDL.L....A....VCsr..daaFKPNTETYNVILADIFKGAL-e..
A0A1E4RZ93_CYBJN/199-305 ................................geieyve-------------.-----LT..DDTF...VQH.....H.TQEIQRA.YRM....CDYNRINALYNAMKRNGL.VPSRDVYDMVLSSIAMRD.ID..H......-S....VDDQMSMMLNVYSDL.I....T....NK.......IKPDLHIYSTVIYQLLDKSI-k..
A0A7H9B0S4_ZYGMR/213-327 ...................................tvet--------LPWEE.DTESSLN..PSTF...LTT.....H.INEINEA.YRT....RDYNKINPLYQALKRNGI.VPPLEVYSKVLESLAKRD.LD..K......DD....LDYKMSELLTCYQDM.I....I....NK.......LKPSDEIYNIVLGYLFKGSI-l..
A0A1E5R9W9_HANUV/320-440 ................................vteeyye-----KTKQIWPA.DSDLTLN..TFKF...SNT.....L.TEQIHKA.YDN....NDLNKIYSLYLAMKRNNC.TPNVETFDLIIKSLCSRD.MD..N......KD....LDERMFHILTCYQDL.I....S....MK.......MKPLVSTYHDIILALLNGSL-d..
A0A1X7R8Q5_9SACH/168-286 .....................................fe----NDDGKVWEE.DTETDLN..PNEY...LKV.....H.IEQIDKC.YNL....KQYSRINALYQSLKRNNI.TVPLETYEKILESFAKRT.FDvnN......KN....LDEKMFSLLNCYHDI.I....N....NR.......LKPTAKIYNIVLLQIFKNSI-v..
A0A2U9R9C0_PICKU/194-332 sihdlesklsklkirnldssnnkyieefkkfpniddafd-------------.----HM-..SENP...LKI.....Q.EFTIDNL.MNQ....NKFNEVLPVFNRMRNNGL.VPTLPIYNKVLKSIPLRQ.T-..N......ES....LENNMTHLLNIYSDL.L....S....NN.......IKPNMETYEIVIGSLVNSSL-i..
A0A1G4M912_LACFM/174-291 ....................................tvv----EESSGPWEP.DTEEELN..VDTF...LQT.....Q.TTQIRKC.YEA....GQYDQINALYQSLKRNNI.VPPLEVYSMVIESVCKRE.LD..N......DN....IDNRMFQLLNCYQDL.L....N....NK.......LKPTDEIYNMVIGCLLNGSI-v..
C4QZW9_KOMPG/169-288 ..................................gkksa------QIEELEE.TAEPQQE..EQSStsgMED.....E.IRMIHSF.VSQ....KRYNEVFALYLRAKAKEI.KLDRSVYTMVLRAITKRE.T-..N......ET....VEEKLTHLLNVYSDL.L....T....SN.......IKPNKDIYELVIGSLLAGA--tk.
Q6BZ89_DEBHA/170-298 .....................................qi---NETAYEELIE.DKEEDF-..ESNL...LHT.....Q.ISNIEAI.YAKq.gpTELNLIYPLYQTLKRNCLqLPSIHLYNIVLKSIVERK.LD..Nda.rtfEN....IESRLTNLLTVYQDI.L....V....GSs....eqVKPNKETYEIVLNELLRGSLQ...
G8JSB0_ERECY/172-292 .................................slrlee----QYYVSAWEP.DTESCLN..SETF...LQT.....N.IKEIERC.VQI....KDYNRVNAIYQALKRNGI.LPPVETFAQIMRSIHLRE.LD..S......DD....LDNKMFQLLSCYQDL.I....S....NK.......LKPTDEIYTIIIGALLQGSIT...
G3AYV1_CANTC/159-280 .........................svedahksepleyd-------------.----DF-..-ESF...KTT.....Q.ISKINSL.FEE....EDYNLIFPIYQSLKRNHMgLGSTELYNKVLSSLLLRE.FD..Nsm..qlED....IEIRLTNLLTVYQDF.Lf.faN....EQ.......MKPDFSTYNIVIGGLLKGSL-d..
A0A1D8PDF0_CANAL/296-419 ..........................sqphtttqenitv-------------.----DTF..EQDF...LAS.....K.VSKIVST.FETystpDDLNIIYPLYQAVKRNDLkLPSIDVYNIVLKSILNRS.LN..Sel..tlDS....IEGKLTVLLTVYQDI.L....A....AG.......IKPNKETYNIVVTALLKGSLQ...
A0A1E3QKA1_9ASCO/241-369 ............................qarlekleipl-----------AA.QLQTLLD..TDTF...AAT.....Q.ILLLRNA.FKT....QDYGRVYAMYQALARNGFhLATVDDYNILLLAISRRSpVY..NtadcidES....VEENLSKLLTVYEAL.L....S....QSh.....tVRPTSETYAIVLALLLDGA--af.
A0A421JRR4_9ASCO/253-378 ...........................vefvknmhtttv-------------.AQERQF-..EGHF...LQT.....Q.IDNITSA.FNNfkqpQDLNIIYPLYQAIKRNELtLPTIELYNIVLDSIVRRS.LD..Gec..tlQA....IETKLTNLLTVYQDI.L....S....TG.......LKPNKETYNVVVDSLLDSSL-k..
A0A225AJW1_9EURO/185-295 ......................tsaeseisleqstdana-------------.-------..EKSY...IA-.....-.SNKVADL.AVA....EKYAEIPASFEALLREGL.TPTVEAYNSLLLAAIKLH.TD..S......YH....---AVPKALDVYSDM.L....R....RR.......VMPNQETYKTLVAVLVSRAV-e..
A0A4P6XIG7_9ASCO/186-315 ...........................eepshasevpdg-------------.--EHEPF..EERF...LRS.....Q.VTQIRQA.FENyvsaEDLNVIFPMYQSLKRNDIlLPSIEEYNMVLKSIAMRS.LD..Get..tlTA....MESKLTCLLTIYQDI.L....S....AAli..hahCRPNAETFLIVLGSLFKGS--kd.
A0A367Y3K8_9ASCO/293-418 ..........................kttevvvevpsqk-------------.--VDTF-..EKDF...LAT.....Q.ISNITSA.FNNhacpEDLNIIYPLYQAVKRNNLtLPTIDLYNIVLKSILKRD.LN..Nts.ldlCS....IEERLTTLLTVYQDI.L....N....SG.......MKPDKETYNLVVNALLDGSLQ...
A0A448YEV7_BRENA/225-334 ....................nrvkfensktepvspstis-------------.-------..----...---.....Q.EQVIDNM.LSL....GQNNEVLAVYFRMRGSNI.LPSIDVYNKILKSIQLRE.TD..E......T-....SEQKLTHLLNVYSDM.L....S....NN.......LKPSDKTYELVIEPLLKGSV-h..
A5DWP5_LODEL/329-457 ...........................dtsnvkkvsdad-----------ET.DHYNEF-..NDHF...LTT.....Q.TRLLRNA.YEQysspQDLDVIYPIYQSIKRNGLtLPEVDLYDIVLRSIANRK.LD..Sel..eiTA....IENKLTNLLTVYQDL.L....C....VA......gLKPSLETYTIVVTSLLDASL-a..
A0A1L0DEP8_9ASCO/183-315 .............................hilkveelpe---------TAQE.PVEEPF-..ESSF...KRS.....Q.ENKIVSV.FAAhtssDDLNIIYPLYQSLKRNGIaLSSIYEYNIVLKSIAMRS.LD..Seh..tlET....TESRLTCLLTVYQDI.L....A....ACsq..npeCKPNYETFNIVLDGIFDGAV-r..
A7TIW8_VANPO/209-328 ..................................tinni-----NNDFPWEK.DNEESLN..KDTY...LKA.....H.MDSIDKA.FIK....KDYNIINALYQSLKRNDC.VPSIETYYKILYSIAHRD.LD..S......DD....INYKMFQILSCYEDIiI....K....NK.......LKPTDEIYSVLLENLFKGSI-i..
A0A4P9ZHF7_9ASCO/166-296 ..........................vtpsdnveptlnv-------------.-EDEHF-..KESF...LAS.....L.LSKIVSI.FTHhtdsAELNTIYPLYQSLRRNDIdLPSVHEYNIVLKSICQRA.LD..Ser..tpQS....IELKLTSLLTVFQDL.L....N....ACar..npaLLPNAETYKIILPCIFDGVI-h..
A0A1E4SN51_9ASCO/155-276 ................................ppvaqle------------S.TESETF-..ESNF...FQT.....Q.ISSILDI.YNNcsspEQLNMIYPLYQSLKRNDItLPTIELYNVILHSISMRS.LD..Sel..tsES....IESKLTNLLTIYQDI.L....K....SS.......LKPNAETFNIIVTNLFDGSI-n..
B6QAG0_TALMQ/181-289 ..............avdstaheltidvnaeksivasgrv-------------.-------..----...---.....-.----VQL.AVE....EKYAEIPAAFEAILRDGV.TPSVEAYNSLLQAAIKLH.TD..S......YH....---AVPKALDVYSDM.L....R....RR.......VIPNQETYKTLIAVLVSRAV-e..
A0A1E3PSL4_9ASCO/341-443 ....................................lpv-------------.------Q..KQKV...LDE.....H.IFAISDC.ISK....HEFIPAIKHYAQLKSEDL.IPPMETFNNILYALNETK.QP..G......AD....MEPILADILTVYSDM.L....E....KN.......VTADVQTYSILISALLSG---gna
A0A376B6B6_9ASCO/209-328 ......................................k-ILIKEPQPAWEA.DTEVTLN..RAQF...LKQ.....T.VKEIDDClMNK....KDYNKIYSLYNALKRNDI.VPSVEVYSKIIKSLCIRD.LD..S......KS....LDDKMFNLLNCYQDI.I....N....NK.......IKPTPDIYDQVIKTLFDGSI-i..
I2H228_TETBL/101-218 .................................isatai--------SAAAA.NSDQGFD..SDSF...LRT.....H.IAQINAC.FQS....RDYNKVNALYQSLKRNNI.VPPLQIYSKILLSILHRD.LD..L......ND....INYKVFQLLNCYQDIiI....K....NK.......IAPNDSILNILLIALFKCSI-v..
Q75BC4_ASHGO/154-272 .......................................DVRFQEDLPPWQL.DREPCLN..EKTF...LAT.....S.IKEIKTC.MEN....EDYNKVNCIYQALKRNGI.VPPVNTFEQVLCAIKLRD.MD..A......DD....PEGKMVQLLNCYQDL.V....S....NK.......LKPTTEIYTIVIGSLLERAA-t..
G8BQX3_TETPH/272-391 ...............................dneqnied-------NWPW-E.ENESYLN..KETF...LDS.....H.SQKIKEN.FNN....ENYEIILPLYQSIKRNDC.IPSLETYYQIIFSIINRK.FD..S......ND....INYKMYQILSIYEDI.I...iK....HK.......MKPTEDIYNLILQSLFTSSI-k..
C5MEK3_CANTT/294-417 ..........................evaveepaaqkvd-------------.----TF-..EVDF...LAT.....Q.VSNITSA.FDNhkcpEDLNIIYPLYQAVKRNDLtLPSIDLYNIVLKSILQRS.LN..Nte.lelSA....IEERLTTLLTVYQDI.L....S....IG.......LKPNKETYNLIVNALLDGSLQ...
A5DLV0_PICGU/167-302 .......................qfqekspeepqksepe-------------.---ADEA..ISAS...LAT.....NlVNQIVTV.FANhqspQDLNVIYPLYQSLKRNEItLPSIAEYNMVLKAIADRA.LN..Sev..tnED....IESKLTTLLTVYQDI.L....Q....ASvhtksdsLKPNEETFNIILRELFQGA--nk.
A0A2V1B1V1_9ASCO/165-295 ................................qpkieel--------PQESA.PEEPAF-..EESF...QKT.....Q.SDKILHI.YNThtspEDLDIIYPLYQALKRNDIaLPSIQLYNIVLESILSRA.LD..Ngt.pslSS....IESRLTNLLTVYQDI.LylcsT....TS.......LRPDNSTYDLVLKGIFEGCV-e..
G8B5U2_CANPC/262-388 .................................qltkts------QKSPTKV.GVEDSF-..ENGF...LES.....Q.IANITNA.FENygdkKDLDMIYPLYQSIKRNGLtLPSVELYNMVLKSIIDRF.ID..Nev..eiGA....IERKLTNLLTVYQDI.L....Y....AN.......LKPDNETYNLVVNAMLDSTL-k..
A0A1G4JSW1_9SACH/186-302 ....................................pps-----ETLSPWEP.DTEESLN..PQTF...LRT.....Q.EKEIRRH.FEQ....KNFNKINALYQSLKRNEI.VPSLEIYSMVIESVCKRS.LD..N......DN....LDNRMFHLLSCYQDL.I....T....NK.......LRPTEQIYNMVIGALFEGSI-m..
A0A364KWT5_9EURO/179-289 ............dntadsaaheltidinaeksivasgrv-------------.-------..----...---.....-.----VQL.AVE....EKYAEIPAAFEAILRDGV.TPSVEAYNSLLQAAIKLH.TD..S......YH....---AVPKALDVYSDM.L....R....RR.......VMPNQETYKTLIAVLVSRAV-e..
G0WHF0_NAUDC/196-312 ..................................thips-------SSPWEI.DTETSLN..PKTY...LST.....H.INEINKA.YLM....QDFNKINSLYHSLKRNNI.IPPIETFEKILDSISKRL.MD..K......FD....LDNKMFEMLSCYQDI.I....N....NK.......LKPSNAIYNILLSSLFKNSI-m..
A0A421J6P1_9ASCO/165-299 ...........iqespeapneksepedpeaisaalaasl-------------.-------..----...---.....-.VNQLVTA.FANhqspQDLNVIYPLYQSLKRNEItLPSIAEYNMVLRAIASRA.LN..Sel..tnED....IESKLTTLLTVYQDI.L....Q....ASahtksdaLKPNEETFNIILQELFQGA--nd.
M3IMX3_CANMX/292-416 .............................pvqtepssqp-------------.VKEDTF-..ETDF...LAS.....K.ISSITST.FTShtnaDDLNIIYPLYQSVKRNNLnLPSIDLYNIVLKSILQRS.LN..Nte.ndlVS....IEERLTTLLTVYQDI.L....S....IG.......MKPNKETYELVVNALLDGSLQ...
A0A1G4J8S0_9SACH/217-335 ....................................dsr---TDPRVSPWEP.DTEESLN..PQTF...LDT.....Q.TKQIKKA.FDC....GDYNSINAHYQALQRNSI.IPTVEIYEIVIESVSRRD.LD..N......DN....VDNRMFQLLNCYQDL.I....N....NK.......MKPSEQIYNAVIGTLLKGSI-l..
A0A8J5USJ0_9ASCO/264-391 .................................saqhsa------KEEHQQS.QQEVDTF..DTDF...LAT.....Q.ITNITNA.YEKhtspQELNIIYPLYQSIKRNDLhLPSIELYNLVLNSIVKRN.LD..Sei..klSS....IESKLTNLLTVYSDI.L....N....AG.......LKPNNETYNIVLEALLDGSL-a..
A0A8H6BW02_CANAX/274-397 ..........................sqphtttqenitv-------------.----DTF..EQDF...LAS.....K.VSKIVST.FETystpDDLNIIYPLYQAVKRNDLkLPSIDVYNIVLKSILNRS.LN..Sel..tlDS....IEGKLTVLLTVYQDI.L....A....AG.......IKPNKETYNIVVTALLKGSLQ...
A0A1E5RYS5_9ASCO/445-564 .....................................qv--PNTSKTSPWPL.DTDDTLN..KEKF...LDQ.....N.IKEIDLC.FTE....GKFNKINSLYMALKRNDI.VPPLPVFEKIIASLCLRD.LD..S......QN....LDERMFNLLNCYQDL.I....N....SK......kYHPSSMIYDHVIATLLEGSI-a..
C5DIY7_LACTC/184-302 ....................................pvs---ANSQASPWEP.DTEETLN..PETF...LQT.....Q.VAHIKHC.FAV....GDYNKINALYQALVRNEI.VPPVEIYATVIESVCMRD.LD..N......DN....VDNRMFQLLNCYQDL.I....N....NK.......LKPTEKIYSLVIGSLLKGSI-l..
#=GC seq_cons ...................................t...................t.ph...ppsF...Lpo.....p.hppIpps.app....pchNhIhslYQulKRNsl.lPol-lYNhVLcSIspRs.lD..s......ps....l-p+lopLLslYQDl.L....s....sp.......lKPsp-TYslVlssLhcGSl.t..
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