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Database: Pfam
Entry: RPM2
LinkDB: RPM2
Original site: RPM2 
#=GF ID   RPM2
#=GF AC   PF08579.8
#=GF DE   Mitochondrial ribonuclease P subunit (RPM2)
#=GF AU   Mistry J, Wood V
#=GF SE   manual
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.50;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1409716
#=GF RT   A 105-kDa protein is required for yeast mitochondrial RNase P
#=GF RT   activity. 
#=GF RA   Morales MJ, Dang YL, Lou YC, Sulo P, Martin NC; 
#=GF RL   Proc Natl Acad Sci U S A. 1992;89:9875-9879.
#=GF RN   [2]
#=GF RM   16024791
#=GF RT   Rpm2p, a component of yeast mitochondrial RNase P, acts as a
#=GF RT   transcriptional activator in the nucleus. 
#=GF RA   Stribinskis V, Heyman HC, Ellis SR, Steffen MC, Martin NC; 
#=GF RL   Mol Cell Biol. 2005;25:6546-6558.
#=GF DR   INTERPRO; IPR013888;
#=GF CC   Ribonuclease P (RNase P) generates mature tRNA molecules by
#=GF CC   cleaving their 5' ends.  RPM2 is a protein subunit of the yeast
#=GF CC   mitochondrial RNase P.  It has the ability to act as
#=GF CC   transcriptional activator in the nucleus where it plays a role
#=GF CC   in defining the steady-state levels of mRNAs for some
#=GF CC   nucleus-encoded mitochondrial components [2].
#=GF SQ   42
#=GS I2H228_TETBL/100-218      AC I2H228.1
#=GS Q75BC4_ASHGO/154-272      AC Q75BC4.2
#=GS C4QZW9_PICPG/169-288      AC C4QZW9.1
#=GS W1QF10_OGAPD/186-302      AC W1QF10.1
#=GS G8ZNG9_TORDC/178-296      AC G8ZNG9.1
#=GS A5DWP5_LODEL/327-457      AC A5DWP5.1
#=GS G8BQX3_TETPH/270-391      AC G8BQX3.1
#=GS G8B5U2_CANPC/262-388      AC G8B5U2.1
#=GS G0VBZ9_NAUCC/169-285      AC G0VBZ9.1
#=GS J7RB45_KAZNA/187-305      AC J7RB45.1
#=GS D4B3F8_ARTBC/221-334      AC D4B3F8.1
#=GS C5DP63_ZYGRC/229-346      AC C5DP63.1
#=GS G8B8J5_CANPC/259-385      AC G8B8J5.1
#=GS G8YC00_PICSO/162-289      AC G8YC00.1
#=GS G8JSB0_ERECY/172-292      AC G8JSB0.1
#=GS G8YEF0_PICSO/161-289      AC G8YEF0.1
#=GS E7QIW2_YEASZ/163-281      AC E7QIW2.1
#=GS Q59MC4_CANAL/285-419      AC Q59MC4.1
#=GS H2B2G8_KAZAF/191-312      AC H2B2G8.1
#=GS Q59MB1_CANAL/285-419      AC Q59MB1.1
#=GS C5DIY7_LACTC/184-302      AC C5DIY7.1
#=GS C5MEK3_CANTT/288-417      AC C5MEK3.1
#=GS M3IMX3_CANMX/289-416      AC M3IMX3.1
#=GS G3AYV1_CANTC/157-280      AC G3AYV1.1
#=GS A5DLV0_PICGU/167-302      AC A5DLV0.2
#=GS G3AFT0_SPAPN/246-371      AC G3AFT0.1
#=GS A0A099P4T0_ISSOR/195-332  AC A0A099P4T0.1
#=GS F2SR18_TRIRC/222-335      AC F2SR18.1
#=GS C4YEE5_CANAW/284-418      AC C4YEE5.1
#=GS S6E6U9_ZYGB2/192-309      AC S6E6U9.1
#=GS Q6FQG6_CANGA/166-285      AC Q6FQG6.1
#=GS RPM2_YEAST/163-281        AC Q02773.1
#=GS M2MYW6_BAUCO/226-340      AC M2MYW6.1
#=GS G0WHF0_NAUDC/196-312      AC G0WHF0.1
#=GS Q6CRB1_KLULA/206-324      AC Q6CRB1.1
#=GS F2PK58_TRIEC/222-335      AC F2PK58.1
#=GS C4Y2H9_CLAL4/149-279      AC C4Y2H9.1
#=GS A3GG14_PICST/174-298      AC A3GG14.2
#=GS A7TIW8_VANPO/209-328      AC A7TIW8.1
#=GS Q6BZ89_DEBHA/170-298      AC Q6BZ89.2
#=GS B6QAG0_PENMQ/178-289      AC B6QAG0.1
#=GS K0KVB8_WICCF/202-318      AC K0KVB8.1
I2H228_TETBL/100-218                 ................................aisatai--------SAAA...ANSDQGFD....SDSFLRTH.IAQINACFQS....RDYNKVNALYQSLKRNNI-VPPLQIYSKILLSILHRDLDL.....NDINYKVFQLLNCYQDIiI...KNK.......IAPNDSILNILLIALFKCSI-v..
Q75BC4_ASHGO/154-272                 .......................................DVRFQEDLPPWQ...LDREPCLN....EKTFLATS.IKEIKTCMEN....EDYNKVNCIYQALKRNGI-VPPVNTFEQVLCAIKLRDMDA.....DDPEGKMVQLLNCYQDL.V...SNK.......LKPTTEIYTIVIGSLLERAA-t..
C4QZW9_PICPG/169-288                 ..................................gkksa------QIEELE...ETAEPQQEe.qsSTSGMEDE.IRMIHSFVSQ....KRYNEVFALYLRAKAKEIKL-DRSVYTMVLRAITKRETN-.....ETVEEKLTHLLNVYSDL.L...TSN.......IKPNKDIYELVIGSLLAGA--tk.
W1QF10_OGAPD/186-302                 ..............................mgetgetae-----------K...SEQAKEVD....PATPLSVH.ERLIDELLSS....NRPSEVLAVYFNLRGKGL-VPTTALYNKVLRSIPQRTDTG.....ESAEDKLTHLLNVYSDM.L...SNN.......LKPSDETYELVVGPLLKGA--qn.
G8ZNG9_TORDC/178-296                 ....................................eqv---IEQVVSPWE...EDTEPCLN....HETFLATQ.VAEIERCYAK....GDYNMINSLYQALKRNGI-VPPVNVYFKVLESLAKRDLDK.....DDLDYKMSELLTCYQDM.I...VSK.......LKPSDEIYNTVLGCLFKGSI-l..
A5DWP5_LODEL/327-457                 ..........................andtsnvkkvsda----------DE...TDHYNEF-....NDHFLTTQ.TRLLRNAYEQysspQDLDVIYPIYQSIKRNGLTLPEVDLYDIVLRSIANRKLDSel.eiTAIENKLTNLLTVYQDL.L...CVA......gLKPSLETYTIVVTSLLDASL-a..
G8BQX3_TETPH/270-391                 ..............................nhdneqnie--------DNWP..wEENESYLN....KETFLDSH.SQKIKENFNN....ENYEIILPLYQSIKRNDC-IPSLETYYQIIFSIINRKFDS.....NDINYKMYQILSIYEDI.I..iKHK.......MKPTEDIYNLILQSLFTSSIK...
G8B5U2_CANPC/262-388                 ......................................q-LTKTSQKSPTK...VGVEDSF-....ENGFLESQ.IANITNAFENygdkKDLDMIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L...YAN.......LKPDNETYNLVVNAMLDSTL-k..
G0VBZ9_NAUCC/169-285                 ....................................tps-----ENDFPWE...KDTELSLN....KNTFLNTH.INEITKCYQN....GDLNKINSLYHSLKRNNV-IPPMGIYEVVLNSIAERKLDE.....NDLDNKMFEMLTCYQDI.L...SNK.......MKPSAIVYNILLNSLFKSSI-l..
J7RB45_KAZNA/187-305                 ....................................dli-----DNTSPWE...QDTETGLN....KDTYLQTH.LRQIDECYKT....GDYNMINSLYQSLRRNDI-VPPLQTYEIIFHSFNKRPFDDn...nLNLNEKMFQLLNCYQDL.L...KNK.......LKPTTTIYNILLFQIFKNSI-v..
D4B3F8_ARTBC/221-334                 .....................iqesivsprtpvndttpy------------...--------....EKKQAESR.SNAIVELAKD....GAHAQVPAAFESLLRDGI-KPTASAYNALLEAAIRLHPE-.....--AHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d..
C5DP63_ZYGRC/229-346                 ....................................skq----RDSMSPWE...EDKEPCLN....KDTFLRTH.TDQINKCYEN....GDLNSINSLYQALKRNDI-IPPLKVYEQILDSVARRQFDN.....DDLDYKIAELLTCYQDL.I...MNR.......LKPSDRIYNTVLECLFKASI-a..
G8B8J5_CANPC/259-385                 ......................................q-LTKTSQKSPTK...VGVEDSF-....ENGFLESQ.IANITNAFENygdkKDLDIIYPLYQSIKRNGLTLPSVELYNMVLKSIIDRFIDNev.eiGAIERKLTNLLTVYQDI.L...YAN.......LKPDDETYNLVVNAMLDSTL-k..
G8YC00_PICSO/162-289                 ................................gtlknds--------TEDP...EDTSNEF-....ETRFLKTQ.TDNILEIYKSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIATRTLDNdi.nmGAIEARLTNIMTVYQHL.L...DEIs....psLRPSSTTYEIVLRELFKGAA-e..
G8JSB0_ERECY/172-292                 ...............................slrleeqy------YVSAWE...PDTESCLN....SETFLQTN.IKEIERCVQI....KDYNRVNAIYQALKRNGI-LPPVETFAQIMRSIHLRELDS.....DDLDNKMFQLLSCYQDL.I...SNK.......LKPTDEIYTIIIGALLQGSIT...
G8YEF0_PICSO/161-289                 ................................igalknd-------QTEDP...EDTSNEF-....ETRFLKTQ.TDNILEIYNSg.drNKLNLIYPLYQAIVRNNITIPSVDIYNVVLDSIAARTLDNdi.smGAIEARLTNIMTVYQHL.L...DEIs....psLRPSSTTYEIVLRELFKGA--te.
E7QIW2_YEASZ/163-281                 ......................................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l..
Q59MC4_CANAL/285-419                 .......................................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAG.......IKPNKETYNIVVTALLKGSLQ...
H2B2G8_KAZAF/191-312                 ...................................qrki----QDDEDPWE...KDTDESLN....KTTFLQTH.IDQINNCYRI....EDYNKINSLYQSLKRNNI-VPPIEIYEKIFDSFNKRNFDQn..tnLLINEKMYQLLNCYQDL.I...NSK.......LKPTTTIYNSLLEQIFKNSI-i..
Q59MB1_CANAL/285-419                 .......................................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAS.......IKPNKETYNIVVTALLKGSLQ...
C5DIY7_LACTC/184-302                 .....................................pv--SANSQASPWE...PDTEETLN....PETFLQTQ.VAHIKHCFAV....GDYNKINALYQALVRNEI-VPPVEIYATVIESVCMRDLDN.....DNVDNRMFQLLNCYQDL.I...NNK.......LKPTEKIYSLVIGSLLKGSI-l..
C5MEK3_CANTT/288-417                 ...........................qstnvpevavee----------PA...AQKVDTF-....EVDFLATQ.VSNITSAFDNhkcpEDLNIIYPLYQAVKRNDLTLPSIDLYNIVLKSILQRSLNNtelelSAIEERLTTLLTVYQDI.L...SIG.......LKPNKETYNLIVNALLDGSLQ...
M3IMX3_CANMX/289-416                 .............................tkkpvqteps----------SQ...PVKEDTF-....ETDFLASK.ISSITSTFTShtnaDDLNIIYPLYQSVKRNNLNLPSIDLYNIVLKSILQRSLNNtendlVSIEERLTTLLTVYQDI.L...SIG.......MKPNKETYELVVNALLDGSLQ...
G3AYV1_CANTC/157-280                 .....................vtsvedahksepleyddf------------...--------....-ESFKTTQ.ISKINSLFEE....EDYNLIFPIYQSLKRNHMGLGSTELYNKVLSSLLLREFDNsm.qlEDIEIRLTNLLTVYQDF.LffaNEQ.......MKPDFSTYNIVIGGLLKGSL-d..
A5DLV0_PICGU/167-302                 ..........................qfqekspeepqks-----------E...PEADEAI-....-SASLATNlVNQIVTVFANhqspQDLNVIYPLYQSLKRNEITLPSIAEYNMVLKAIADRALNSev.tnEDIESKLTTLLTVYQDI.L...QASvhtksdsLKPNEETFNIILRELFQGA--nk.
G3AFT0_SPAPN/246-371                 .............................efvknihttq-----------S...KPVEPQF-....EAHFLQTQ.IDNITSAFNNfkqpQDLNIIYPLYQAIKRNELALPTVELYNIVLESIVRRSLDGes.tlQAIESKLTNLLTVYQDI.L...STG.......LKPNKSTYNLVVDSLLDSSL-k..
A0A099P4T0_ISSOR/195-332             ihdlesklsklkirnldssnnkyieefkkfpniddafdh------------...------M-....SENPLKIQ.EFTIDNLMNQ....NKFNEVLPVFNRMRNNGL-VPTLPIYNKVLKSIPLRQTN-.....ESLENNMTHLLNIYSDL.L...SNN.......IKPNMETYEIVIGSLVNSSL-l..
F2SR18_TRIRC/222-335                 ........................vqesivsprtpvndi------------...-----SLY....EKKQAESR.SNAIVDLAKD....GAHAQVPAAFESLLRDGI-KPTASAYNVLLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d..
C4YEE5_CANAW/284-418                 .......................................QVVAEQQKQPPSqphTTTQENITvdtfEQDFLASK.VSKIVSTFETystpDDLNIIYPLYQAVKRNDLKLPSIDVYNIVLKSILNRSLNSel.tlDSIEGKLTVLLTVYQDI.L...AAG.......IKPNKETYNIVVTALLKGSLQ...
S6E6U9_ZYGB2/192-309                 .....................................qr---EEQFSSPWE...EDTEPCLN....KDTFLQTH.VDHIRRCQEL....GDLNKINSLYQSLKRNDI-VPPVDVYATILDSIARRQFDK.....DDLDYKVSELLTCYQDM.I...TNK.......LKPSDEVYNTVLGCLFHSSV-i..
Q6FQG6_CANGA/166-285                 .......................................DLLELEKEYNWE...KDTDDDLN....PQTYLSTH.IDQINKHFVK....GNYNIINALYKSLKRNGIAIQDREVLTKVLISLARREMDD.....LDIDNKVFELLSCYQDI.I...TNR.......IKPNLEIYNIVLETLFKSSI-v..
RPM2_YEAST/163-281                   ......................................s-LLKDENAPVWK...EDTEPCLN....KSTYLQTH.IDEINRCYEQ....KNYNKINSLYQSLKRNDI-VPPLEIFTKVLDSLCKRPLDN.....NDLDNKMYELLTCYQDM.I...NNR.......LKPPDEIYNIVLLSLFKGSI-l..
M2MYW6_BAUCO/226-340                 .............eehtvstpatlytstdsfssaeadfy------------...--------....--------.SSEILELSAK....KEYERVPAAFQAMLRAGVQQPKPATYHALLTSVVELT---.....QGKHQKVPKALEVYSDM.L...RRK.......VTPHVESFNLLISLLARR---ase
G0WHF0_NAUDC/196-312                 ..................................thips-------SSPWE...IDTETSLN....PKTYLSTH.INEINKAYLM....QDFNKINSLYHSLKRNNI-IPPIETFEKILDSISKRLMDK.....FDLDNKMFEMLSCYQDI.I...NNK.......LKPSNAIYNILLSSLFKNSI-m..
Q6CRB1_KLULA/206-324                 .......................................DVRLDDSIPAWE...TDLEPCLN....KEAFLETQ.SKLIEDCMKN....KNYNQVNAIYKSLIRNEI-VPPLSLFEQVLTSICRRDLDQ.....NNIDNQMFELLNCYQDI.I...QNK.......LKPSAEIYHLVVGSLLSGSIR...
F2PK58_TRIEC/222-335                 ........................vqesivsprtpvndi------------...-----SLY....EKKQAESR.SNAIVELAKD....GAHAKVPAAFESLLRDGV-KPTASAYNALLEAAIRLHP--.....-ETHNAVPKALDVYSDM.L...RRS.......VMPNEDTYKIIVQLLSTRSL-d..
C4Y2H9_CLAL4/149-279                 ..............................tsskvpsen----------IP...EKEEDDF-....ESSFQKSQ.VDKIVNTFIShecpEDLNVIYPLYQGLKRNHIPLPSVHEYNIVLKSISMRELDSqc.tiSAIESKLTSLLTVYEDL.L...AVCsr..daaFKPNTETYNVILADIFKGAL-e..
A3GG14_PICST/174-298                 ...................................kita------ETPSLR...TDTDGSF-....ESNFLHNQ.IAAITSTYSSytdaSELNIIYPLYQSLKRNDLTLPSIQLYNIVLSSIEKRALDSef.tlEAIENKLTNLLTVYQDI.L...SSG.......NKPDTETYNLIIRNLLQGNL-d..
A7TIW8_VANPO/209-328                 ..................................tinni-----NNDFPWE...KDNEESLN....KDTYLKAH.MDSIDKAFIK....KDYNIINALYQSLKRNDC-VPSIETYYKILYSIAHRDLDS.....DDINYKMFQILSCYEDIiI...KNK.......LKPTDEIYSVLLENLFKGSI-i..
Q6BZ89_DEBHA/170-298                 .....................................qi---NETAYEELI...EDKEEDF-....ESNLLHTQ.ISNIEAIYAKq.gpTELNLIYPLYQTLKRNCLQLPSIHLYNIVLKSIVERKLDNdartfENIESRLTNLLTVYQDI.L...VGSs....eqVKPNKETYEIVLNELLRGSLQ...
B6QAG0_PENMQ/178-289                 .............denavdstaheltidvnaeksivasg------------...--------....--------.--RVVQLAVE....EKYAEIPAAFEAILRDGV-TPSVEAYNSLLQAAIKLHTDS.....YH---AVPKALDVYSDM.L...RRR.......VIPNQETYKTLIAVLVSRAV-e..
K0KVB8_WICCF/202-318                 .........................kpilqspdqyneli------------...---PEEQN....DETFLTQQ.TNQILEANDS....YQYEKIHSLYMAIKRNNI-IPSRELYAIVLSSIVERKID-.....DSLDDKLSTLLNVYQDL.V...SNK.......IKPDSQIYSIVINKLLSASI-e..
#=GC seq_cons                        ..................................................p...tsp-.sh.....cpsFLpop.lspIspsaps....p-hNhI.sLYQulKRNsl.lPslclYshVLcSIhcRphDs.....psl-sKlspLLolYQDl.L...ssp.......lKPsp-hYslllssLhcuSl....
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