GenomeNet

Database: Pfam
Entry: RTX
LinkDB: RTX
Original site: RTX 
#=GF ID   RTX
#=GF AC   PF02382.13
#=GF DE   RTX N-terminal domain
#=GF AU   Mian N, Bateman A
#=GF SE   Pfam-B_833 (release 5.2)
#=GF GA   19.60 19.60;
#=GF TC   20.00 80.20;
#=GF NC   18.60 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9628576
#=GF RT   Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
#=GF RT   enterohemorrhagic Escherichia coli O157:H7 derived from Sakai
#=GF RT   outbreak. 
#=GF RA   Makino K, Ishii K, Yasunaga T, Hattori M, Yokoyama K, Yutsudo
#=GF RA   CH, Kubota Y, Yamaichi Y, Iida T, Yamamoto K, Honda T, Han CG,
#=GF RA   Ohtsubo E, Kasamatsu M, Hayashi T, Kuhara S, Shinagawa H; 
#=GF RL   DNA Res 1998;5:1-9.
#=GF DR   INTERPRO; IPR018504;
#=GF DR   MEROPS; M10;
#=GF DR   TC; 1.C.11;
#=GF CC   The RTX family of bacterial toxins are a group of cytolysins and
#=GF CC   cytotoxins. This Pfam family represents the N-terminal domain
#=GF CC   which is found in association with a glycine-rich repeat domain
#=GF CC   and  hemolysinCabind Pfam:PF00353.
#=GF SQ   13
#=GS C0AY16_9ENTR/7-149     AC C0AY16.1
#=GS C0AY17_9ENTR/1-358     AC C0AY17.1
#=GS CYAA_BORPE/498-954     AC P0DKX7.1
#=GS M9X2T8_MANHA/4-651     AC M9X2T8.1
#=GS A4ES15_9RHOB/269-761   AC A4ES15.1
#=GS J2LL45_9BURK/519-899   AC J2LL45.1
#=GS M4RAK6_BIBTR/6-653     AC M4RAK6.1
#=GS C9R5U4_AGGAD/7-654     AC C9R5U4.1
#=GS A3N0W6_ACTP2/5-654     AC A3N0W6.1
#=GS E3BKQ9_9VIBR/614-1128  AC E3BKQ9.1
#=GS A3N292_ACTP2/8-652     AC A3N292.1
#=GS F4HD31_GALAU/956-1589  AC F4HD31.1
#=GS F5S905_9NEIS/3-656     AC F5S905.1
C0AY16_9ENTR/7-149                ..............................................................................................................................................tqikts-----LQSAKQ...SATKKLQSAgqstKNALKKAAGQARKA....GDKLILLIPKDY..-QGQGSSLNDLVKAADELGIEVQYEEKRQYRDSQTIFwNRRKKLLGLTERGVAIFAPQLDKLLQK..YPNVGNKLgGSAENLGSHLGKVG------------------------------------------------------------...----.----------------------------..-------.-------....-------...---------.---------.......-----------------.--...--.--...-------..--------------------------------------------------------------------------------.--------------------------------------------------......---------------..----..-----------------..-----------------------.-----.--------------------------.--------------.....--------------------------------------........----------------------.-------.....----------------------.........------------------.-----------gifff.......
C0AY17_9ENTR/1-358                ....................................................................................................................................................-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.------------------------------MQINELIKKQRNGEDVSSTELAKASIDLINQLIDTASSINNNID...AFSQ.QLNNLGSVLSNTKHLSGVGNKLQNLPDL..GKLGTGL.DTVSGIL....SAISASF...ILSNADADA.GTKAAAGVE.......LTTKILGNVGKAVSQYI.LA...QR.VA...QGLSTTA..ASAGLIASAVSLAISPLSFLAISDQFKRANQIEEYAQRFKKLGYEGDSLLAAFRKETGAIDAALTTISTVLNSVSAGVSA.AATASLVGAPISALVGAVSGIITGILEASKQSMFEHVANKMANTIAEWEK......KHGKNYFENGYDARH..SAFL..EDNFELLSKYSKEHSTE..LSILITQQHWDDLIGELAGVTKN.GARVF.SGKAYVDYYKEGKHLEKK--------.--------------.....--------------------------------------........----------------------.-------.....----------------------.........------------------.-----------i...........
CYAA_BORPE/498-954                ..................................................................................................................aslsaavfglgeassavaetvsgffrgssrwagg-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.--------------------------------------------------------------------------...----.---------------------------F..GVAGGAM.ALGGGIA....AAVGAGM...SLTD-DAPA.GQKAAAGAE.......IALQLTGGTVELASSIA.LAlaaARgVT...SGLQVAG..ASAGAAAGALAAALSPMEIYGLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAVSI.AAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKIDELGG......--PQAYFEKNLQARHeqLANS..DGLRKMLADLQAGWNAS..SVIGVQTTEISKSALELAAITGN.ADNLK.SVDVFVDRFVQGERV-----AGQPVV.LDVAAGGIDIASRK....gERPALTFITPLAAPGEEQRRRTKTGKSEFTTFVEIVGK.......qDRWRIRDGAADTTI-DLAKVVS.QLVDANG....vLKHSIKLDVIGGDGDDVVLANA.........SRIHYDGGAGTNTVSYAA.-----------lgrqdsitvsad
M9X2T8_MANHA/4-651                ....................................................................................................................................................RLTTLSNGLKNtltATKSGLHKA....GQSLTQAGSSLKTG....AKKIILYIPQNYqyDTEQGNGLQDLVKAAEELGIEVQREERNNIATAQTSL.GTIQTAIGLTERGIVLSAPQIDKLLQK..T-KAGQAL.GSAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQ-----NNSNQHALAKAGLELTNSLIENIANSVKTLD...EFGE.QISQFGSKLQNIKGLGTLGDKLKNIGGL..DKAGLGL.DVISGLL....SGATAAL...VLADKNAST.AKKVGAGFE.......LANQVVGNITKAVSSYI.LA...QR.VA...AGLSSTG..PVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSA.AAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEK.....nNHGKNYFENGYDARY..LANL..QDNMKFLLNLNKELQAE..RVIAITQQQWDNNIGDLAGISRL.GEKVL.SGKAYVDAFEEGKHI-----KADKLVqLDSANGIIDVSNSGk...aKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRV........DSWKITDGAASSTF-DLTNVVQrIGIELDNagnvtKTKETKIIAKLGEGDDNVFVGS.........GTTEIDGGEGYDRVHYSR.GNYGALTIDAT............
A4ES15_9RHOB/269-761              .............................................................................................ddieqydstlrsasfkagvnllstsraaaafavnpensveghvtnagflgealls-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.--------------------------------------------------------------------------...----.----------------SSGDLLEAAGHLnvSKGARGF.AAVALVAgasgSFVPTAK...LLADPDLSP.EMRRVVEAEvglqgtaLAFAAVENVLGIAELAVtAG...SK.AA...TVLGKAV..PIIGAIGSVIG-AINPVKWAEFEQKQDRIDAIRDS-------GTYSSGLLGDLLQESKTAEAAFYGTTTALDV-TTGVTAgVLAATGVGAPISAAVGLIGGAISAIVGAFEQVALEAIADRYADKIRTDAEg...npQTVEAFFKGSFDQKQ..ERIK..EHYTEFFEEFIAENDVD..RVLALGGQGLDATDIELAAISKTsGELNK.TARNYVETFTTNGWQPGSHALSPSSG.FET--NVIQLDKAH....gSKSFLTFTTPLFAAGTEDISRRETGKNEYQTTLRIKDL........SGWEIRDHGVNETTFNMSKVVS.SAQDRFG.....NSMEIGIAIQAAAGDDALFAYE.........AQTSFDGGSGQDTASYAR.-----------lsgvela.....
J2LL45_9BURK/519-899              ......................................................................................................................................daasfsgatrlvrh-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.--------------------------------------------------------------------------...----.----------------------------..-------.-------....-------...---------.---------.......-----------------.--...--.--...--RSLMG..PMGLTFTAGAMLALSPLEIYALAKQSEYATDLDKLAS----GGYAGHGLLADFYREKNGVQAGIFATSAILDIVSSLAVA.ACVVSGVGAPIAIPLGLVVTGISAVFRAAEYAFIEKMAEKAVQKIYAYVDpkdssrKGPQAYFENSLNAQN..K-SL..SDSA-MLTDYLAKLQGNygSVVWVDTQTMSPQAMELAALIRN.TTDLV.TAKAYIERFSNGISR-----PTASLR.IDAETGELNLDNDGtaklgSTQLLTFLNPLLAPGKETRKKGHVGGKTSSTSLTLTDAngtaytigKGWTINDGNASSTM-DLTNVVT.KVINKNM....tDKLELPITVNGGGGDDKVIANA.........SAMRFDGGDGFDVVDYQH.-----------landggiaait.
M4RAK6_BIBTR/6-653                ...................................................................................................................................................t-LSTLSNGIRStltATRGGLNRA....GQSLTQAGQTLKNG....AKKIILYIPKDYkyDSGSGNGLQDLVKAAEELGIEVQKEEGNDIAKAQTSL.GTIQNVLGLTERGIVLSAPQLDKLLQK..N-KVGQAL.GSSESIAQNFSQAKTVLSGVQSILGSVLAGMDLDEALQ-----NESDQLTLAKAGLELTNSLIENIANSVQTLD...AFSE.QISQFGSKLQNVKGLGALGDKLKNIGGL..DKAGLGL.DVISGLL....SGATAAL...VLADKDAST.AKKVGAGFE.......LANQVVGNITKAVSSYI.LA...QR.VA...AGLSSTG..PVAALIASTVALAISPLSFAGIADKFDRAKSLENYAERFKKLGYEGDSLLAEYQHGTGTIDASVTAINTALAAIAGGVSA.AAAGSVVASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEK.....nNGGKNYFENGYDARY..LANL..QDNMKFLLNLNKELQAE..RVIAITQQQWDSNIGDLAGISRL.GEKVL.SGKAYVDAFEEGQHL-----KADKLVqLDSAKGIIDVSNTGe...aKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLHINRV........DSWQIKDGAASSTF-DLTNVVQrIGVELDHaenviKTKETKIVATLGDGDDNVFVGS.........GTTEIDGGEGYDRVHYSR.GNYGALTIDAT............
C9R5U4_AGGAD/7-654                ............................................................................................................................................lntkqqaa---QFANSVAD...RAKENIDAA....KEQLQKALDKLGKT....GKKLTLYIPKNY..--KKGNGLTALIKAAQKLGIEVYHEGKDGPALTNGIL.NTGKKLLGLTERGLTLFAPELDKWIQG..NKHLSNSV.GSTGNLTKAIDKVQSVLGTLQAFLNTAFSGMDLDALIKARQNGKNVTDVQLAKASLNLINELIGTISSITNNVD...TFSK.QLNKLGEALGQVKHFGSFGDKLKNLPKL..GNLGKGL.GALSGVL....SAISAAL...LLANKDADT.ATKAAAAAE.......LTNKVLGNIGKAITQYL.IA...QR.AA...AGLSTTG..PVAGLIASVVSLAISPLSFLGIAKQFDRARMLEEYSKRFKKFGYNGDSLLGQFYKNTGIADAAITTINTVLSAIAAGVGA.ASAGSLVGAPIGLLVSAITSLISGILDASKQAVFEHIANQLADKIKAWEN......KYGKNYFENGYDARH..SAFL..EDSLKLFNELREKYKTE..NILSITQQGWDQRIGELAGITRN.GDRIQ.SGKAYVDYLKKGEELAKHSDKFTKQI.LDPIKGNIDLSGIK.....GSTTLTFLNPLLTAGKEERKTRQSGKYEFITELKVKGR........TDWKVKGVPNSNGVYDFSNLIQ.HAVTRDN.....KVLEARLIANLGAKDDYVFVGS.........GSTIVNAGDGYDVVDYSK.GRTGALTIDGR............
A3N0W6_ACTP2/5-654                ...................................................................................................................................................t-LSSLKSSLQQglkNGKNKLNQA....GTTLKNGLTQTGHSlqngAKKLILYIPQGY..DSGQGNGVQDLVKAANDLGIEVWREERSNLDIAKTSF.DTTQKILGFTDRGIVLFAPQLDNLLKK..NPKIGNTL.GSASSISQNIGKANTVLGGIQSILGSVLSGVNLNELLQ----NKDPNQLELAKAGLELTNELVGNIASSVQTVD...AFAE.QISKLGSHLQNVKGLGGLSNKLQNLPDL..GKASLGL.DIISGLL....SGASAGL...ILADKEAST.EKKAAAGVE.......FANQIIGNVTKAVSSYI.LA...QR.VA...SGLSSTG..PVAALIASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGA.ASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANKVHDRIVEWEK......KHNKNYFEQGYDSRH..LADL..QDNMKFLINLNKELQAE..RVVAITQQRWDNQIGDLAAISRR.TDKIS.SGKAYVDAFEEGQHQ-----SYDSSVqLDNKNGIINISNTN....rKTQSVLFRTPLLTPGEENRERIQEGKNSYITKLHIQRV........DSWTVTDGDASSSV-DFTNVVQrIAVKFDDagniiESKDTKIIANLGAGNDNVFVGS.........STTVIDGGDGHDRVHYSR.GEYGALVIDAT............
E3BKQ9_9VIBR/614-1128             .............................................................................kfdkwskaadlsdagmralsignniasavkwhskdvdendhagqvaqatslastymglvqdgmdgfvelsk-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.--------------------------------------------------------------------------...----.-----------------FFDATKGMKNL..HA-GTGAgSAIVGVG....PQIA-SLvqaVLNVKDAPD.EYKAHYIGE.......AVMQ-GANLAMGLTVGV.LT...AK.AAitgTTVSSAV..PVLGIVASL-ASAINPVQWAAFEQSKDHINDVDAKTDESSDAYETSAQYLTELLEDIHGTEVGFYSASTAVGVLGGIGTT.AAAATGVGAPVALVIAGITAGLQGMLEGLKQVHLDNVAEDMAEKIRAFNEg...vaGFFDQSFEHSTDKAL..SDFV..DDAKHFIEKGYDSVSGL..GSVQMT-----ASDLELAGLSGV.GGELKqTQKHFSGFIEKADLETGE--WNREEIkIDASQGVIERTNVNgaatgKDNMLTFVTPMAAAGNENISTEHVSKNRYETTINISNL........KGWTIKDGGDNTTF-DLDNIVT.KAQSFRAq...kELIDIPLSIEANAGDDNFLMSDitgritetdRTGIFDGGSGKDSATYA-.-----------nlkhleqg....
A3N292_ACTP2/8-652                ...................................................................................................................................................r-VKGLIDSLNQ...HTKSAAKSG....AGALKNGLGQVKQA....GQKLILYIPKDY..QASTGSSLNDLVKAAEALGIEVHRSEKNGTALAKELF.GTTEKLLGFSERGIALFAPQFDKLLNK..NQKLSKSLgGSSEALGQRLNKTQTALSALQSFLGTAIAGMDLDSLLRRRRNGEDVSGSELAKAGVDLAAQLVDNIASATGTVD...AFAE.QLGKLGNALSNTR-LSGLASKLNNLPDL..SLAGPGF.DAVSGIL....SVVSASF...ILSNKDADA.GTKAAAGIE.......ISTKILGNIGKAVSQYI.IA...QR.VA...AGLSTTA..ATGGLIGSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLLASFYRETGAIEAALTTINSVLSAASAGVGA.AATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATKLANKIDEWEK......KHGKNYFENGYDARH..SAFL..EDTFELLSQYNKEYSVE..RVVAITQQRWDVNIGELAGITRK.GADAK.SGKAYVDFFEEGKLLEKDPDRFDKKV.FDPLEGKIDLSSIN.....KTTLLKFITPVFTAGEEIRERKQTGKYEYMTELFVKGK........EKWVVTGVQSHNAIYDYTNLIQ.LAIDKKG.....EKRQVTIESHLGEKNDRIYLSS.........GSSIVYAGNGHDVAYYDK.TDTGYLTFDGQ............
F4HD31_GALAU/956-1589             mtdflnqigikeeltkpiqglsnsildtaktltyvvqidpttdkgklsiadssfelaksanqivsyimdlsgssselshniantahqilsisqdrllsignnisalanadkltkegvkiivdssfaitsdvngfitdvvktvgkdgnp-----------...---------....--------------....------------..-------------------------------------.---------------------------..--------.-------------------------------------------KVGSALSLSNSIIDMGHSIANLIQSDVNTSSgkaAIAEgSIKLIGNINGLVSDVLSLSNASTAVSEA..ISSSAG-.GILTNLS....SLIGSSI...KLHNWSNMTqADQIAVGFD.......IGLKAVSTIATGVGT--.TA...QS.IA...KIIGTTTmlPQIGAAVSGIALAASPLEIKGLVDEHKYVKQIDSLASETKTYGYQGDELLASLLNEKFALNTAYTATDIALNLATTAISV.AATASVIGAPIAAIAGVVRGAIGGIMSAIKQPALEHIAKRYVDQIEEYGD......I--QKYFDQNTEATL..NKFYasQEVIQSFKQLQKLYNVD..NIITLDGVASSDSAIELAAITKL.VDQMN.KANNYAQLIRNGEID--KALSAQYLS.MDAKTGVLEITAPG.....-NSLIKFNSPLFAPGVEEARRKAVGKNNFYTDLIINGP........NEHTINDGAGNNIF--ISNDKY.ASVLYDEn..gkLLKHINLNINAGDGNDTYIADN.........GHSLFNGGNGTDSVSYNN.EHIHGIVV---hgr.........
F5S905_9NEIS/3-656                ...........................................................................................................................................lattkaklk-------SGAQ...AGVQALNKA....GHAAKTGTVAAGKAtvagAKSLYLTIPKDY..DIEKGGSLNELIKAADELGIARLQEDANNVESAKKSI.DTVEKLLSFTQTGVAVSAKKLDELLQKysSSKLAKSL.GSSANIDSKLTKTNHILSTLSSFLGTALAGMDLDSLVK----QGDASATDLAKASLDLINELVNNISNSVQSIE...AFSE.QLGRLGAAISQTKGLSGLGNKLQNLPNF..GKANLAL.EMISGLL....SGISAGF...TLADKNAST.EKKVAAGFE.......LSNQVIGNVTKAISSYV.LA...QR.AA...AGLSTTG..AVASLITASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSA.AAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKILAWEK.....eNGGKNYFENGYDARH..AHYL..ERNLKLLSELNKELQAE..RVIAITQQRWDANIGELAGITKL.GDRIS.SGKAYADAFEDGKKL----DGASNVT.VDTRTGVVDISNANg...kKTQALHFTSPLLTAGTETRERVQNGKYSYINQLKFNRV........KSWTVKDGEANSRL-DFSKVIQhVAFNDEDgrlsgKTEEIALNVNAGSGNDDIFAGQ.........GKMNVDGGTGHDRVFYSKdGGLGQVNVDGT............
#=GC seq_cons                     ...................................................................................................................................................p..................................................................................................................................................................................t.sst.tLupu.lphhtplht.hts.sts.p...thup.plt.hGth.t.hp.h.uhustLpslspL..spuuhGh.shloGlh....SsluAuh...lLust-Ass.tpKsuAGhE.......lu.pllGNlsculophl.lA...QR.sA...sGLSoTu..PsuulIuSsluLAISPLpahulucpacpAcpl-phupchpchGYpGDuLLApah+-sssl-AulTulsTsLusluuGVoA.AAsuSlVGAPlAllVuulTGhIouILcuuKQuhhE+lAs+hssKIhpapc......ptscsYFEsuaDARa..ts.L..pDshchLpphpcchps-..pVlulTpQphDsshhELAuIo+h.G-clp.SuKAYVDhFccGcph.....tssp.s.lDstpGhI-losss....tpsphlpFhoPLhssGpEpRcRhpsGK.pahTpLplpth........csWplpDGsusssh.DhoNllp.hulphcs....hcph-htl.sphGsGsDslhsss.........ups.hDGGsGhDpVpYu+........................
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