GenomeNet

Database: Pfam
Entry: RepB-RCR_reg
LinkDB: RepB-RCR_reg
Original site: RepB-RCR_reg 
#=GF ID   RepB-RCR_reg
#=GF AC   PF10723.8
#=GF DE   Replication regulatory protein RepB
#=GF AU   Mistry J, Coggill P
#=GF SE   PRODOM_PD763888
#=GF GA   20.90 20.90;
#=GF TC   21.10 21.00;
#=GF NC   20.60 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9409148
#=GF RT   Rolling-circle replication of bacterial plasmids. 
#=GF RA   Khan SA; 
#=GF RL   Microbiol Mol Biol Rev. 1997;61:442-455.
#=GF DR   INTERPRO; IPR019661;
#=GF CC   This is a family of proteins which regulate replication of
#=GF CC   rolling circle replication (RCR) plasmids that have a
#=GF CC   double-strand replication origin (dso). Regulation of
#=GF CC   replication of RCR plasmids occurs mainly at initiation of
#=GF CC   leading strand synthesis at the dso, such that Rep protein
#=GF CC   concentration controls plasmid replication [1].
#=GF SQ   32
#=GS W8VCH7_YEREN/5-74       AC W8VCH7.1
#=GS H6SHZ0_SALEN/1-81       AC H6SHZ0.1
#=GS A6TI22_KLEP7/1-83       AC A6TI22.1
#=GS A8H1Z2_SHEPA/59-137     AC A8H1Z2.1
#=GS Q93GS8_SALTY/8-88       AC Q93GS8.1
#=GS A0A0T9WTS5_SALET/1-81   AC A0A0T9WTS5.1
#=GS D5X772_THIK1/15-89      AC D5X772.1
#=GS A0A0J8YDS6_9BACT/1-83   AC A0A0J8YDS6.1
#=GS A0KKI4_AERHH/6-74       AC A0KKI4.1
#=GS A0A0J8YC76_9BACT/1-82   AC A0A0J8YC76.1
#=GS A0A0G3Q3B1_KLUIN/1-70   AC A0A0G3Q3B1.1
#=GS A0A0G3Q732_KLUIN/1-60   AC A0A0G3Q732.1
#=GS Q326V9_SHIDS/1-83       AC Q326V9.1
#=GS F7V1X3_CLOSS/1-49       AC F7V1X3.1
#=GS D2TV77_CITRI/1-83       AC D2TV77.1
#=GS G2H1Q1_9ENTR/3-77       AC G2H1Q1.1
#=GS A0A168VTJ1_9ENTR/1-81   AC A0A168VTJ1.1
#=GS W8U9R8_YEREN/1-81       AC W8U9R8.1
#=GS N9VKC6_9GAMM/14-80      AC N9VKC6.1
#=GS D4EA89_SEROD/1-60       AC D4EA89.1
#=GS A0A0M2KAP0_9GAMM/1-79   AC A0A0M2KAP0.1
#=GS Q7ARH5_YERPE/1-82       AC Q7ARH5.1
#=GS G2H038_9ENTR/2-77       AC G2H038.1
#=GS C4IEW2_CLOBU/1-54       AC C4IEW2.1
#=GS F0IHS3_9FLAO/36-96      AC F0IHS3.1
#=GS A0A168WBS8_9ENTR/1-70   AC A0A168WBS8.1
#=GS A0A0M2KAN3_9GAMM/1-84   AC A0A0M2KAN3.1
#=GS A0A120CTL8_HYPSL/24-91  AC A0A120CTL8.1
#=GS A0A0M2K4K4_9GAMM/1-78   AC A0A0M2K4K4.1
#=GS Q326M6_SHIDS/1-81       AC Q326M6.1
#=GS R6T165_9FIRM/3-61       AC R6T165.1
#=GS J2DEV1_KLEPN/1-60       AC J2DEV1.1
W8VCH7_YEREN/5-74                  ................vherkrrp------------..-----KGPQKSNASYQRDFWERRKL.THS.....RIVMVVPNEVKEDLELLSSVYGKTKTEVIEQLIKM------akdg.......
H6SHZ0_SALEN/1-81                  ........................MSQIENAVTSSS..KRIYRKGNPLSSAEKKRLSISRKKT.THK.....ELNVFIQNIHKESLQQLCEETGTTQAQMIELLIEREMAKR-a..........
A6TI22_KLEP7/1-83                  ........................MSRSADKTTSSTnaKRAYRKGKPMSASERQLAAIARKRE.THK.....EVKVFVKNPLKDVMIAVCEEEGLTQAQFIEKLLERELTE--rg.........
A8H1Z2_SHEPA/59-137                qtsnssveatvfiksfagnmykah------------..--------------KA--RLYRKKLgAKK.....MLNVAITPKHMQNLEYICKSQGMQKNKVIEMMIEGSLQH--lin........
Q93GS8_SALTY/8-88                  ........................MSQIENAVTSSS..KRIYRKGNPLSSAEKKRLSISRKKT.THK.....ELNVFIQNIHKESLQQLCEETGTTQAQMIELLIEREMAKR-a..........
A0A0T9WTS5_SALET/1-81              ........................MSQIENAVTSSS..KRIYRKGNPLSSAEKKRLSISRKKT.THK.....ELNVFIQNIHKESLQQLCEETGTTQAQMIELLIEREMAKR-a..........
D5X772_THIK1/15-89                 ..............pgrprkgeer------------..-------EPLSDAERARRYAARKRA.KARnaalvAVTVYLSPQATDRLTELGIRRQATRAEVLEKLILQ------adpf.......
A0A0J8YDS6_9BACT/1-83              ........................MPRVVNADTSSSqdKRPYRKGNALSPAEKKRMSVSRKKE.THK.....EVNVFIRNEYKEVLLQLCKDAGVTQAGMIEKWIAREMAK--nq.........
A0KKI4_AERHH/6-74                  .................kvssaqd------------..-----------NAERQRQHVKRKQE.THS.....RLQCWISNRHAERLAMLGLQLEDSQASLIEQAID-------llyqheleqkq
A0A0J8YC76_9BACT/1-82              ...........mpttqpataqpkh------------..KQTRNRKNPMSDSERQLSYVARKRE.ALK.....EIKIFVEPELKKALMLMCQDEGVTQADILQRLIKHEA----elkg.......
A0A0G3Q3B1_KLUIN/1-70              .....................msr------------..--VVERQVHKSNLDKQKDYRNRIRD.THD.....QLNLYLPKDAKRMLIEITKVKKLTQAEVIEFLVKS------yydglk.....
A0A0G3Q732_KLUIN/1-60              ........................------------..---------MSASEKQQAAVARKKL.THK.....ELKIYLRNAIKDRLVVECEKAGLTQAEYIERLLQQA-----fdeld......
Q326V9_SHIDS/1-83                  ........................MSQTENAVTSSLsqKRFVRRGKPMTDSEKQMAAVARKRL.THK.....EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
F7V1X3_CLOSS/1-49                  ....................mprp------------..-----------------------KK.DAH.....VLNIKLESSVYEDLDRFCEETGVTKTAAVEKILRS------flddy......
D2TV77_CITRI/1-83                  ........................MSQTENAVTSSSgaKRAYRKGNPLSDAEKQRLSVARKRA.SFK.....EVKVFLEPKYKAMLMQMCHEDGLTQAEVLTALIKSEAQKR-c..........
G2H1Q1_9ENTR/3-77                  ..................eqnekk-----------P..KREYRKGNPLTLTERTKRYKDKQKK.NNR.....EMRLFIPTDLGNQFTDHCREIKKSRSEVVSKLIEDY-----iksv.......
A0A168VTJ1_9ENTR/1-81              ........................MSQVVNAVTSSS..KRPYRKGNPLSAAERQQKAVARKKA.THK.....EVRVFVRDSLKSQLQLMCENEGITQAEMIERLIEMESAKL-g..........
W8U9R8_YEREN/1-81                  ........................MSQIENAVTSSS..KRTYRKGNPLSEADRQKIASARKRA.THK.....ELKVFIKPEIKEYLSNLCEEDGVTQAEVLEKLIEREAF---srk........
N9VKC6_9GAMM/14-80                 ....................eprr------------..-------EALDSATRQRLHVRRKQE.THA.....RLQCWISRRHANRLAVLVERLEDSQASLIEQAID-------llyeqels...
D4EA89_SEROD/1-60                  ........................------------..---------MSDSERQQAAVARKRA.THK.....EVKIFVRNSLKHRLVEMCEADGVTQAEMIEKWIELEYQSR-s..........
A0A0M2KAP0_9GAMM/1-79              ........................MSQAVNAATSSS..KRAYRKGNPLSVSERQQALMERRKE.THK.....EIKVYVPTVLKERLQNLCEAEGVSQAEMISRLIAD------agip.......
Q7ARH5_YERPE/1-82                  ........................MSQIENAVTSSS..KRAYRKGNPLTGAEKQRMSVSRKKE.THK.....AINVFIQNDLKNELLQLCEDSGLTQTEMIERWIQREKAAR-tn.........
G2H038_9ENTR/2-77                  ..................teqnek-----------K..KREYRLGNPLTLTEYTNRYRDRKKE.NNR.....EMRLFIPIDLGNRFTEHCREIGKSRSEIVSNLIEDYIQ---svc........
C4IEW2_CLOBU/1-54                  .......................m------------..--------------------ARQKK.DGV.....YINYYIRKDIKEKLDEYCEEVGQTNTLALERILGQ------fldkyfeekk.
F0IHS3_9FLAO/36-96                 ..................ymylck------------..--------------KINRSMARERI.KGK.....ALNIRVSEEFITLLKLLSEKKGMSQANLIEYLVRKEADA--iq.........
A0A168WBS8_9ENTR/1-70              .....................mnr------------..--VTERQEQKSNPEFQREYRNRIRE.THD.....QLNLYLPKDAKRMLIEITKVKKLTQAEVIEFLVKS------yydglk.....
A0A0M2KAN3_9GAMM/1-84              ........................MSQATNAATSSSkeKRAYRKGNPMSATERQLAAIARKRE.THK.....EVNVFIRNPMKAQLLHLCKQEGLTQGEMIEKLIQIETKRR-ge.........
A0A120CTL8_HYPSL/24-91             .....erraraerragmavndrrr------------..---------------------KKRE.TRN....tPLNTRVRKSVSDLAKALCDAEGISQADLLEQLIEKAA----ktkg.......
A0A0M2K4K4_9GAMM/1-78              .......maedegavrgtkvgrpr------------..-------KYETKSDKQRAYITQKLQ.TKV.....QTKVLLSPDGRDTLNKLCKLRGVTQGELVTELIKKY-----asev.......
Q326M6_SHIDS/1-81                  ........................MSQIENAVTSSP..KRIYRKGNPLTGAEKQRISVSRKKG.THK.....AINVFIQSELKDDLTQLCKDSGLTQKEMIEHWILKEKAA--vd.........
R6T165_9FIRM/3-61                  ..........ytkasnkavqkysa------------..------------------------K.TYD.....QIKVLVKKGEREEIKNYAESQGMSLNGYINKLIKDDMK---tad........
J2DEV1_KLEPN/1-60                  ........................------------..---------MTDSEKQMAAVARKRL.THK.....EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
#=GC seq_cons                      .............................................p.hosuE+pphhhsRK+p.TH+.....clplalpsphKcpLtplCccpGhTQAphIEpLIcpt.....t..........
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