GenomeNet

Database: Pfam
Entry: Rho_Binding
LinkDB: Rho_Binding
Original site: Rho_Binding 
#=GF ID   Rho_Binding
#=GF AC   PF08912.6
#=GF DE   Rho Binding
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1s1c
#=GF GA   23.00 23.00;
#=GF TC   24.00 26.90;
#=GF NC   22.90 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14660612
#=GF RT   Structural insights into the interaction of ROCKI with the
#=GF RT   switch regions of RhoA. 
#=GF RA   Dvorsky R, Blumenstein L, Vetter IR, Ahmadian MR; 
#=GF RL   J Biol Chem. 2004;279:7098-7104.
#=GF DR   INTERPRO; IPR015008;
#=GF CC   Rho Binding Domain is responsible for the recognition and
#=GF CC   binding of Rho binding domain-containing proteins (such as ROCK)
#=GF CC   to Rho, resulting in activation of the GTPase which in turn
#=GF CC   modulates the phosphorylation of various signalling proteins.
#=GF CC   This domain is within an amphipathic alpha-helical coiled-coil
#=GF CC   and interacts with Rho through predominantly hydrophobic
#=GF CC   interactions [1].
#=GF SQ   184
#=GS Q90Y37_DANRE/964-1032   AC Q90Y37.1
#=GS H2YZD4_CIOSA/902-964    AC H2YZD4.1
#=GS H2UA41_TAKRU/947-1016   AC H2UA41.1
#=GS G3WFV8_SARHA/978-1046   AC G3WFV8.1
#=GS Q7PRV2_ANOGA/957-1021   AC Q7PRV2.5
#=GS G5BTS2_HETGA/948-1014   AC G5BTS2.1
#=GS G1LYV5_AILME/936-1004   AC G1LYV5.1
#=GS F7G2Y1_MONDO/929-995    AC F7G2Y1.1
#=GS F6TXY5_CALJA/336-404    AC F6TXY5.1
#=GS F6PML3_HORSE/892-960    AC F6PML3.1
#=GS F1NM42_CHICK/934-1004   AC F1NM42.1
#=GS H2YZD1_CIOSA/912-980    AC H2YZD1.1
#=GS F7B5F7_ORNAN/813-881    AC F7B5F7.1
#=GS H3JD90_STRPU/1137-1205  AC H3JD90.1
#=GS H0VLY1_CAVPO/933-1001   AC H0VLY1.1
#=GS G3HUX3_CRIGR/807-873    AC G3HUX3.1
#=GS F1N319_BOVIN/931-999    AC F1N319.2
#=GS H2TR73_TAKRU/968-1036   AC H2TR73.1
#=GS G1K8E0_ANOCA/929-997    AC G1K8E0.1
#=GS H9GX85_DANRE/1-34       AC H9GX85.1
#=GS Q4SK04_TETNG/962-1032   AC Q4SK04.1
#=GS E2B7A8_HARSA/942-1006   AC E2B7A8.1
#=GS G7PLM0_MACFA/948-1016   AC G7PLM0.1
#=GS E9Q9W8_MOUSE/672-740    AC E9Q9W8.1
#=GS H0ZS66_TAEGU/955-1023   AC H0ZS66.1
#=GS B4JK88_DROGR/958-1023   AC B4JK88.1
#=GS E9PYM9_MOUSE/978-1046   AC E9PYM9.1
#=GS G9KLM5_MUSPF/934-1002   AC G9KLM5.1
#=GS B4L7Y2_DROMO/948-1013   AC B4L7Y2.1
#=GS ROCK1_MOUSE/948-1014    AC P70335.1
#=GS F6XP01_XENTR/926-991    AC F6XP01.1
#=GS Q4SLR2_TETNG/929-995    AC Q4SLR2.1
#=GS G1LJU4_AILME/932-998    AC G1LJU4.1
#=GS H9HIG2_ATTCE/543-607    AC H9HIG2.1
#=GS E0VY20_PEDHC/943-1007   AC E0VY20.1
#=GS H2YZC8_CIOSA/952-1020   AC H2YZC8.1
#=GS G3SZH5_LOXAF/979-1047   AC G3SZH5.1
#=GS B4PXV3_DROYA/1457-1522  AC B4PXV3.1
#=GS H2NW04_PONAB/893-959    AC H2NW04.1
#=GS F7FMP0_MONDO/929-995    AC F7FMP0.1
#=GS B4NEV8_DROWI/935-1000   AC B4NEV8.1
#=GS E7F9X9_DANRE/951-1017   AC E7F9X9.1
#=GS H0WCP0_CAVPO/14-80      AC H0WCP0.1
#=GS D2HJZ0_AILME/650-716    AC D2HJZ0.1
#=GS D3ZZU3_RAT/978-1046     AC D3ZZU3.1
#=GS ROCK1_RAT/948-1014      AC Q63644.1
#=GS O73732_XENLA/966-1034   AC O73732.1
#=GS G1NC22_MELGA/919-985    AC G1NC22.2
#=GS G1SMN4_RABIT/658-724    AC G1SMN4.1
#=GS G1TDS7_RABIT/932-1000   AC G1TDS7.1
#=GS F6QSI7_HORSE/892-960    AC F6QSI7.1
#=GS H2YZD2_CIOSA/920-988    AC H2YZD2.1
#=GS Q9VXE3_DROME/962-1027   AC Q9VXE3.1
#=GS H2YZD5_CIOSA/1031-1099  AC H2YZD5.1
#=GS H3CU32_TETNG/961-1029   AC H3CU32.1
#=GS H2YZD0_CIOSA/956-1024   AC H2YZD0.1
#=GS D2HH98_AILME/927-995    AC D2HH98.1
#=GS H2UA39_TAKRU/958-1024   AC H2UA39.1
#=GS F7B5E8_ORNAN/823-891    AC F7B5E8.1
#=GS G3RVG1_GORGO/950-1016   AC G3RVG1.1
#=GS G3U7Q1_LOXAF/978-1046   AC G3U7Q1.1
#=GS B3MRC3_DROAN/950-1015   AC B3MRC3.1
#=GS H2VBN2_TAKRU/975-1043   AC H2VBN2.1
#=GS Q33BP0_PAROL/1-62       AC Q33BP0.1
#=GS H0X189_OTOGA/949-1017   AC H0X189.1
#=GS F1LR70_RAT/948-1014     AC F1LR70.1
#=GS B7ZRE4_XENLA/964-1032   AC B7ZRE4.1
#=GS D5LG91_STRPU/947-1015   AC D5LG91.1
#=GS F7CQ75_XENTR/938-1006   AC F7CQ75.1
#=GS G3S3X0_GORGO/948-1014   AC G3S3X0.1
#=GS G1R545_NOMLE/889-955    AC G1R545.1
#=GS F1NRH6_CHICK/921-987    AC F1NRH6.1
#=GS F1PU60_CANFA/322-388    AC F1PU60.1
#=GS Q8CC95_MOUSE/22-90      AC Q8CC95.1
#=GS ROCK2_MOUSE/978-1046    AC P70336.1
#=GS F4WIC6_ACREC/942-1006   AC F4WIC6.1
#=GS H2MTH9_ORYLA/957-1023   AC H2MTH9.1
#=GS G9KLM4_MUSPF/974-1040   AC G9KLM4.1
#=GS F7INQ2_CALJA/978-1046   AC F7INQ2.1
#=GS E2CYN3_DANRE/966-1034   AC E2CYN3.1
#=GS H2VBN4_TAKRU/966-1034   AC H2VBN4.1
#=GS H3CSS4_TETNG/960-1026   AC H3CSS4.1
#=GS B4DRJ9_HUMAN/336-404    AC B4DRJ9.1
#=GS H2RCA0_PANTR/978-1046   AC H2RCA0.1
#=GS E3WZX5_ANODA/793-857    AC E3WZX5.1
#=GS G3PH51_GASAC/962-1030   AC G3PH51.1
#=GS G1NML1_MELGA/933-1001   AC G1NML1.2
#=GS F6VT97_MACMU/979-1047   AC F6VT97.1
#=GS F7DDX8_MONDO/1018-1086  AC F7DDX8.1
#=GS H3B7E8_LATCH/932-1002   AC H3B7E8.1
#=GS E9PF63_HUMAN/735-803    AC E9PF63.1
#=GS ROCK2_HUMAN/978-1046    AC O75116.4
#=GS F1SCR1_PIG/939-1007     AC F1SCR1.1
#=GS G3PZ53_GASAC/956-1022   AC G3PZ53.1
#=GS H9EPT5_MACMU/948-1014   AC H9EPT5.1
#=GS B3NVJ7_DROER/1358-1423  AC B3NVJ7.1
#=GS G1PSW6_MYOLU/932-1000   AC G1PSW6.1
#=GS F1LQT3_RAT/978-1046     AC F1LQT3.1
#=GS E3VQ36_BOMMO/940-1003   AC E3VQ36.1
#=GS G7NKG1_MACMU/948-1014   AC G7NKG1.1
#=GS ROCK1_PANTR/597-663     AC P61584.1
#=GS H2MBM6_ORYLA/974-1042   AC H2MBM6.1
#=GS D4A5S0_RAT/948-1014     AC D4A5S0.1
#=GS E2A893_CAMFO/941-1005   AC E2A893.1
#=GS ROCK2_BOVIN/978-1046    AC Q28021.1
#=GS ROCK2_BOVIN/978-1046    DR PDB; 1UIX A; 979-1045;
#=GS ROCK2_BOVIN/978-1046    DR PDB; 1UIX B; 979-1044;
#=GS F8VPK5_MOUSE/978-1046   AC F8VPK5.1
#=GS D6WNY9_TRICA/941-1005   AC D6WNY9.1
#=GS G7PWH1_MACFA/948-1014   AC G7PWH1.1
#=GS H2YZC9_CIOSA/946-1014   AC H2YZC9.1
#=GS F7INQ6_CALJA/978-1046   AC F7INQ6.1
#=GS ROCK1_RABIT/948-1014    AC O77819.1
#=GS E9QI44_DANRE/946-1014   AC E9QI44.1
#=GS G1LJU8_AILME/948-1014   AC G1LJU8.1
#=GS H3BZ88_TETNG/965-1031   AC H3BZ88.1
#=GS Q5SP91_DANRE/966-1034   AC Q5SP91.1
#=GS H2VBN3_TAKRU/969-1037   AC H2VBN3.1
#=GS F6ZBB4_MACMU/978-1046   AC F6ZBB4.1
#=GS G1PP69_MYOLU/950-1016   AC G1PP69.1
#=GS E4WRQ2_OIKDI/5-49       AC E4WRQ2.1
#=GS G5B595_HETGA/888-956    AC G5B595.1
#=GS F6XUQ9_HORSE/948-1014   AC F6XUQ9.1
#=GS H0ZJ44_TAEGU/920-986    AC H0ZJ44.1
#=GS Q5SP95_DANRE/8-76       AC Q5SP95.1
#=GS F7IR26_CALJA/948-1014   AC F7IR26.1
#=GS G3WFV9_SARHA/942-1010   AC G3WFV9.1
#=GS D9ZGF8_HUMAN/948-1014   AC D9ZGF8.1
#=GS H2P6Y3_PONAB/978-1046   AC H2P6Y3.1
#=GS G3PH56_GASAC/927-995    AC G3PH56.1
#=GS H3C5G4_TETNG/963-1031   AC H3C5G4.1
#=GS Q29IT7_DROPS/935-1000   AC Q29IT7.2
#=GS H3B2B3_LATCH/954-1020   AC H3B2B3.1
#=GS B7Q4S9_IXOSC/844-916    AC B7Q4S9.1
#=GS H2TR74_TAKRU/961-1029   AC H2TR74.1
#=GS B4HAM7_DROPE/950-1015   AC B4HAM7.1
#=GS H3D439_TETNG/978-1046   AC H3D439.1
#=GS H2QEB3_PANTR/948-1014   AC H2QEB3.1
#=GS H2YZC7_CIOSA/961-1029   AC H2YZC7.1
#=GS G3P4V5_GASAC/882-950    AC G3P4V5.1
#=GS G1RV80_NOMLE/978-1046   AC G1RV80.1
#=GS H2UA40_TAKRU/956-1022   AC H2UA40.1
#=GS H3B7E7_LATCH/973-1041   AC H3B7E7.1
#=GS F1R417_DANRE/973-1041   AC F1R417.1
#=GS Q4S6S5_TETNG/1049-1117  AC Q4S6S5.1
#=GS F6R6H8_CIOIN/1036-1104  AC F6R6H8.1
#=GS F1PE53_CANFA/936-1004   AC F1PE53.1
#=GS F1NK88_CHICK/935-1005   AC F1NK88.1
#=GS F1NMU3_CHICK/923-989    AC F1NMU3.1
#=GS Q6A035_MOUSE/367-435    AC Q6A035.1
#=GS H2YZD3_CIOSA/901-970    AC H2YZD3.1
#=GS F1NRH5_CHICK/923-989    AC F1NRH5.1
#=GS G3TF10_LOXAF/948-1014   AC G3TF10.1
#=GS B4M9X3_DROVI/952-1017   AC B4M9X3.1
#=GS F8W847_HUMAN/336-404    AC F8W847.1
#=GS F6RG19_CALJA/895-964    AC F6RG19.1
#=GS F6T5Y1_MACMU/917-983    AC F6T5Y1.1
#=GS Q961D4_DROME/962-1027   AC Q961D4.1
#=GS Q3TBE0_MOUSE/110-176    AC Q3TBE0.1
#=GS A7SW93_NEMVE/1-28       AC A7SW93.1
#=GS ROCK1_BOVIN/355-421     AC Q8MIT6.1
#=GS H2MVL7_ORYLA/631-699    AC H2MVL7.1
#=GS H0X6A1_OTOGA/944-1010   AC H0X6A1.1
#=GS G3HB11_CRIGR/661-729    AC G3HB11.1
#=GS D3ZN37_RAT/460-526      AC D3ZN37.1
#=GS Q14DU5_HUMAN/293-361    AC Q14DU5.1
#=GS H2MVL9_ORYLA/605-673    AC H2MVL9.1
#=GS E9GLV2_DAPPU/955-1020   AC E9GLV2.1
#=GS G3U5Y3_LOXAF/890-956    AC G3U5Y3.1
#=GS Q9U779_DROME/962-1027   AC Q9U779.1
#=GS Q179S5_AEDAE/888-952    AC Q179S5.1
#=GS ROCK1_HUMAN/948-1014    AC Q13464.1
#=GS ROCK1_HUMAN/948-1014    DR PDB; 1S1C X; 948-1013;
#=GS ROCK1_HUMAN/948-1014    DR PDB; 1S1C Y; 948-1014;
#=GS H0VGZ3_CAVPO/948-1014   AC H0VGZ3.1
#=GS B0WWT9_CULQU/951-1015   AC B0WWT9.1
#=GS G1TY77_RABIT/948-1016   AC G1TY77.1
#=GS G1KHH5_ANOCA/950-1016   AC G1KHH5.1
#=GS G3U660_LOXAF/934-1002   AC G3U660.1
#=GS F1MF50_BOVIN/961-1027   AC F1MF50.2
#=GS H9G236_MACMU/978-1046   AC H9G236.1
#=GS H2VBN1_TAKRU/614-682    AC H2VBN1.1
#=GS H2YZC6_CIOSA/961-1029   AC H2YZC6.1
#=GS G3WNF9_SARHA/110-176    AC G3WNF9.1
#=GS H9K8V1_APIME/942-1006   AC H9K8V1.1
#=GS ROCK2_RAT/978-1046      AC Q62868.2
#=GS F7INR3_CALJA/64-130     AC F7INR3.1
#=GS F6R6F3_CIOIN/950-1018   AC F6R6F3.2
Q90Y37_DANRE/964-1032              ............................LTSDVANLANEKEEFNNKL...K.EAE.D..Y...LQNLKNEEQ.SITQVKLALEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
H2YZD4_CIOSA/902-964               ...........leqwrshyereivhlql-------------------...A.KVE.N..E..gANRQKVSEK.-----NDEIIKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
H2UA41_TAKRU/947-1016              ............................LTKDAENLSKEKAELNEKL...Q.TQE.Q..V...MCLFFDRKEdIVNAVKANYEKV...LNTER..TLKTQ..AVNKLAEIMNRKD.
G3WFV8_SARHA/978-1046              ............................LTSDVANLANEKEELNNKV...K.EVQ.E..Q...ISRLKDEET.NISVIKTQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
Q7PRV2_ANOGA/957-1021              ............................LKKSLGNKEYELEDVLQQS...K.KQQ.E..E...LYRLKYEL-.------GELDKCrakLVNET..ILKQQ..AVNKLAEIMNRKD.
G5BTS2_HETGA/948-1014              ............................LTKDIELLRKENEELTDKM...K.KAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G1LYV5_AILME/936-1004              ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F7G2Y1_MONDO/929-995               ............................LTKDIELLRKENEELAEKM...R.KEQ.E..D...YKLKKEEE-.-INNLKASFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
F6TXY5_CALJA/336-404               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F6PML3_HORSE/892-960               ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1NM42_CHICK/934-1004              ............................LTSDVANLANEKEELNNKL...K.EEQ.E..Q...ITKLKEEEA.NIGNIKAQFEKQ...LLNER..TLKTQgkAVNKLAEIMNRK-g
H2YZD1_CIOSA/912-980               ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
F7B5F7_ORNAN/813-881               ............................LTSDVANLANEKEELNNKA...K.EIQ.E..Q...ISRLKDEET.SVSIIKAQYEKQ...LLNER..TLKTQ..AVNKLAEIMNRKD.
H3JD90_STRPU/1137-1205             ...........................l-NNRIMTLNTEKDELNKKL...K.ESS.E..A...QEAMETKHQ.EMEKQMEQNKKL...LGEEK..LKKEQ..AVSKLAEIMNRKD.
H0VLY1_CAVPO/933-1001              ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKEEEI.SAVAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
G3HUX3_CRIGR/807-873               ............................LTKDIEILRKENEELNERM...R.TAE.E..E...YKLNKEEE-.-INNLKVAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
F1N319_BOVIN/931-999               ............................LTSDVANLANEKEELNNKL...K.EAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2TR73_TAKRU/968-1036              ............................LTSDVANLANEKEELNNKL...K.AAI.E..E...SQKSNDWEQ.QICQMKQGFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
G1K8E0_ANOCA/929-997               ............................LTSDVANLANEKEELNNKL...K.EVQ.E..R...IVRINEDEN.DIDLLKTQYEKQ...LAYER..TMKTQ..AVNKLAEVMNRKN.
H9GX85_DANRE/1-34                  ............................-------------------...-.---.-..-...---------.-MKSLTVSYEKQ...IQVEK..TLKIQ..AINKLAEVMKKTD.
Q4SK04_TETNG/962-1032              ............................LTSDVANLANEKEELNNKL...K.AAM.E..E...SQKSNDWEQ.QICQMKQGFEKQ...LQPQRltRVRLQ..AVNKLAEIMNRKE.
E2B7A8_HARSA/942-1006              ...........................f-KKSVEQTLKDKEDLSKRL...K.ELQ.E..Q...LGKAQSNAE.EIEKL----SSK...LKTEQ..VLKQQ..AVNKLAEIMNRKD.
G7PLM0_MACFA/948-1016              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
E9Q9W8_MOUSE/672-740               ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
H0ZS66_TAEGU/955-1023              ............................LTSDVANLANEKEELNNKL...K.EAQ.E..Q...ITKLKEEEA.NVGNIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRK-g
B4JK88_DROGR/958-1023              ............................LHKKLKLKCNECDDQLVQH...K.KQL.D..E...LQQQRTTK-.-DEEIVKLTEKC...-KNEV..LLKQV..AVAKLAEVMNRRD.
E9PYM9_MOUSE/978-1046              ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
G9KLM5_MUSPF/934-1002              ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
B4L7Y2_DROMO/948-1013              ............................LHKKLKSKSSELDEMLAQH...K.KQL.E..E...LQQQRIAK-.-DEEIAKLGEKC...-KNEV..LLKQV..AVAKLTEVMNRRD.
ROCK1_MOUSE/948-1014               ............................LTKDIEMLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-INNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
F6XP01_XENTR/926-991               ............................LTKDVQTLTKANEELSEKA...R.KLE.Q..E...YK-EKEEE-.-IYNLRNSYEKA...INTEK..TLKTQ..AVNKLAEIMNRKD.
Q4SLR2_TETNG/929-995               ............................LTKDAENLSKEKTELNDKL...Q.AQE.Q..E...FLAQKEEI-.-SNTIKANYEKT...LNTER..TLKTQ..AVNKLAEIMNRKD.
G1LJU4_AILME/932-998               ............................LTKDIELLRKENEELTDKM...R.RAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H9HIG2_ATTCE/543-607               ...........................f-KKSVDQTLKEKEDLSKRY...K.ELQ.E..Q...LGKAQSNVE.EIEKL----SSK...LKTEQ..LLKQQ..AVNKLAEIMNRKD.
E0VY20_PEDHC/943-1007              ............................LKKQLDQMSKEREEMTRQL...R.HVQ.E..D...MKKRTNQD-.--EEV-ERLNRV...LKQEI..VLKQQ..AVNKLAEIMNRKD.
H2YZC8_CIOSA/952-1020              ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
G3SZH5_LOXAF/979-1047              ............................LTSDVANLANEKEELNNKL...K.DAQ.D..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
B4PXV3_DROYA/1457-1522             ............................LHKKLGQKAAEYEDLVQQH...K.KQQ.E..E...LTLMRSSK-.-DEEINKLLDKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
H2NW04_PONAB/893-959               ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
F7FMP0_MONDO/929-995               ............................LTSDVANLANEKEELNNKV...K.EVQ.E..R...ML--KDEET.NISVIKSQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
B4NEV8_DROWI/935-1000              ............................LHKKLGLKINECEDLMQQH...K.KQQ.D..E...LTLLRASK-.-DEEIAKLVEKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
E7F9X9_DANRE/951-1017              ............................LTKDVEILSKEKTEFNERI...Q.AQE.Q..E...FAAEREEL-.-TNSIKANYEKA...LNIER..TLKTQ..AVNKLAEIMNRKD.
H0WCP0_CAVPO/14-80                 ............................LTKDNELLRKENEELMDKM...K.KAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
D2HJZ0_AILME/650-716               ............................LTKDIELLRKENEELTDKM...R.RAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
D3ZZU3_RAT/978-1046                ............................LTSDVANLANEKEELNNKL...K.DTQ.E..Q...LSKLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
ROCK1_RAT/948-1014                 ............................LTKDIELLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
O73732_XENLA/966-1034              ............................LTIDVGNLANEKEDLNNRL...K.EAH.E..Q...IQRLKEEEN.SVVTIKTQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRK-l
G1NC22_MELGA/919-985               ............................LTKDVDLITKENSEISEKM...K.KQE.E..E...YKMKKEEE-.-INNIRMQYEKS...INTER..TLKTQ..AVNKLAEIMNRKD.
G1SMN4_RABIT/658-724               ............................LTKDIELLRKENEELTDKM...R.KSE.E..E...YKLQKEEE-.-ISNLKATYEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G1TDS7_RABIT/932-1000              ............................LTGDVANLASEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F6QSI7_HORSE/892-960               ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2YZD2_CIOSA/920-988               ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
Q9VXE3_DROME/962-1027              ............................LHKKLGQKAAEYEDLVQQH...K.KQQ.E..E...LALMRSSK-.-DEEITKLLDKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
H2YZD5_CIOSA/1031-1099             ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
H3CU32_TETNG/961-1029              ............................LTSDVANLANEKEELNNKL...K.AAM.E..E...SQKSNDWEQ.QICQMKQGFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
H2YZD0_CIOSA/956-1024              ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
D2HH98_AILME/927-995               ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2UA39_TAKRU/958-1024              ............................LTKDAENLSKEKAELNEKL...Q.TQE.Q..E...YVDQKEDI-.-VNAVKANYEKV...LNTER..TLKTQ..AVNKLAEIMNRKD.
F7B5E8_ORNAN/823-891               ............................LTSDVANLANEKEELNNKA...K.EIQ.E..Q...ISRLKDEET.SVSIIKAQYEKQ...LLNER..TLKTQ..AVNKLAEIMNRKD.
G3RVG1_GORGO/950-1016              ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G3U7Q1_LOXAF/978-1046              ............................LTSDVANLANEKEELNNKL...K.DAQ.D..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
B3MRC3_DROAN/950-1015              ............................LHKKLSQKSAECEDLVQQH...K.KQQ.E..E...LSQLCGSK-.-DEEIAKLMEKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
H2VBN2_TAKRU/975-1043              ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAKEAEK.QMNSHKVSFERM...LQNER..TLKIQ..AINKLAEVMNRR-v
Q33BP0_PAROL/1-62                  ...........................q------RLSKEKTELNDKL...T.NQK.D..E...YEAQKEEI-.-ANTIKANYEKV...LNTER..TLKTQ..AVNKLAEIMNRKD.
H0X189_OTOGA/949-1017              ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1LR70_RAT/948-1014                ............................LTKDIELLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
B7ZRE4_XENLA/964-1032              ............................LTIDVGNLANEKEDLNNKL...K.ESQ.E..Q...IQKLKEEES.SIVTVKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRK-l
D5LG91_STRPU/947-1015              ...........................l-NNRIMTLNTEKDELNKKL...K.ESS.E..A...QEAMETKHQ.EMEKQMEQNKKL...LGEEK..LKKEQ..AVSKLAEIMNRKD.
F7CQ75_XENTR/938-1006              ............................LTIDVGNLANEKEDLNNKL...K.ETQ.E..L...IQNLKEEES.SIITVKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRK-l
G3S3X0_GORGO/948-1014              ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G1R545_NOMLE/889-955               ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
F1NRH6_CHICK/921-987               ............................LTKDVDLVTKENSEMSEKM...K.KQE.E..E...YKLKKEEE-.-INNIRMQYEKS...INNER..TLKTQ..AVNKLAEIMNRKD.
F1PU60_CANFA/322-388               ............................LTKDNELLRKENEELTDKM...K.RAE.E..E...YKLKKEEE-.-INNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
Q8CC95_MOUSE/22-90                 ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
ROCK2_MOUSE/978-1046               ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
F4WIC6_ACREC/942-1006              ...........................f-KKSVDQTLKEKEDLSKRY...K.ELQ.E..Q...LGKAQSNVE.EIEKL----SSK...LKTEQ..LLKQQ..AVNKLAEIMNRKD.
H2MTH9_ORYLA/957-1023              ............................LRKDVENLSKEKTDLSQEL...R.TQE.E..E...YEAQKEEI-.-SNSIRAQYEKS...LANER..TLKTQ..AVNKLAEIMNRRD.
G9KLM4_MUSPF/974-1040              ............................LTKDIEVLRKENEEITDKM...R.RAE.E..E...YKLKKEEE-.-ISNLKAAFEKI...INTER..TLKTQ..AVNKLAEIMNRKD.
F7INQ2_CALJA/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
E2CYN3_DANRE/966-1034              ............................LTVDVANLASEKEELNNKL...K.HIQ.Q..K...LEKTKEEEK.QMKSLTVSYEKQ...IQVEK..TLKIQ..AINKLAEVMKKTD.
H2VBN4_TAKRU/966-1034              ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAKEAEK.QMNSHKVSFERM...LQNER..TLKIQ..AINKLAEVMNRR-v
H3CSS4_TETNG/960-1026              ............................LTKDAENLSKEKTELNDKL...Q.AQE.Q..E...FLAQKEEI-.-SNTIKANYEKT...LNTER..TLKTQ..AVNKLAEIMNRKD.
B4DRJ9_HUMAN/336-404               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2RCA0_PANTR/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
E3WZX5_ANODA/793-857               ............................LNKNLTNKSYELDDLMQQC...K.KLQ.D..E...LYVLRLEQ-.------GELDKCktkLLNET..ILKQQ..AVNKLAEIMNRKD.
G3PH51_GASAC/962-1030              ............................LTSDVANLANEKEELNNKL...K.EAM.E..E...SEKSKDWEQ.QISQMKQSFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
G1NML1_MELGA/933-1001              ............................LTSDVANLANEKEELNNKL...K.EEQ.E..Q...IAKLKEEEA.NIGNIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRK-g
F6VT97_MACMU/979-1047              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F7DDX8_MONDO/1018-1086             ............................LTSDVANLANEKEELNNKV...K.EVQ.E..Q...ISRLKDEET.NISVIKSQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
H3B7E8_LATCH/932-1002              ............................LTSDVANLANEKEELNNKL...K.ETH.EqtE...IQKMKDEEL.NIAVIKTQYDKQ...LLNER..TLKTQ..AVNKLAEIMNRKD.
E9PF63_HUMAN/735-803               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
ROCK2_HUMAN/978-1046               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1SCR1_PIG/939-1007                ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
G3PZ53_GASAC/956-1022              ............................LTKAVENLSKEKTDLSEKF...S.SLE.E..D...YAAEKEEI-.-SNTIKSNYEKI...LNTER..TLKTQ..AVNKLAEIMNRKD.
H9EPT5_MACMU/948-1014              ............................LTKDMEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
B3NVJ7_DROER/1358-1423             ............................LHKKLGQKGAEYEDLVQQH...K.KQQ.E..E...LTLMRSSK-.-DEEITKLVDKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
G1PSW6_MYOLU/932-1000              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1LQT3_RAT/978-1046                ............................LTSDVANLANEKEELNNKL...K.DTQ.E..Q...LSKLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
E3VQ36_BOMMO/940-1003              .....................ratidlq--------RKEVDELRRSG...T.ALA.E..RvasLQRLQDEL-.------DRLNKK...LNSEI..MLKQQ..AVNKLAEIMNRKD.
G7NKG1_MACMU/948-1014              ............................LTKDMEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
ROCK1_PANTR/597-663                ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H2MBM6_ORYLA/974-1042              ............................LTEDVAKLASEKEELNNQL...I.ETQ.H..K...LMEAKELEK.EIETMKASFDKQ...LKTEI..TLKNQ..AVSKLTEVMNRKE.
D4A5S0_RAT/948-1014                ............................LTKDIELLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
E2A893_CAMFO/941-1005              ...........................f-KKSVDQTLKEKEDLSKRL...K.ESQ.E..Q...LGKAQFNAE.EIEKL----SSK...LKTEQ..LLKQQ..AVNKLAEIMNRKD.
ROCK2_BOVIN/978-1046               ............................LTSDVANLANEKEELNNKL...K.EAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
#=GR ROCK2_BOVIN/978-1046    SS    ............................XHHHHHHHHHHHHHHHHHH...H.HHH.H..H...HHHHHHHHH.HHHHHHHHHHHH...HHHHH..HHHHH..HHHHHHHHHC-XX.
F8VPK5_MOUSE/978-1046              ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
D6WNY9_TRICA/941-1005              ............................LKKMNEHLSKEREDINRQL...K.QLQ.E..E...FSKKSGNNE.EIDKLKSK----...LQTES..LLKQQ..AVNKLHEVLNRKD.
G7PWH1_MACFA/948-1014              ............................LTKDMEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H2YZC9_CIOSA/946-1014              ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
F7INQ6_CALJA/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
ROCK1_RABIT/948-1014               ............................LTKDIELLRKENEELTDKM...R.KSE.E..E...YKLQKEEE-.-ISNLKATYEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
E9QI44_DANRE/946-1014              ............................LTSDVANLANEKEEFNNKL...K.EAE.D..Y...LQNLKNEEQ.SITQVKLALEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
G1LJU8_AILME/948-1014              ............................LTKDIELLRKENEELTDKM...R.RAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H3BZ88_TETNG/965-1031              ............................LTKDAENLSKEKTELNDKL...Q.AQE.Q..E...FLAQKEEI-.-SNTIKANYEKT...LNTER..TLKTQ..AVNKLAEIMNRKD.
Q5SP91_DANRE/966-1034              ............................LTVDVANLASEKEELNNKL...K.HIQ.Q..K...LEKIKEEEK.QMKSLTVSYEKQ...IQVEK..TLKIQ..AINKLAEVMKKTD.
H2VBN3_TAKRU/969-1037              ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAKEAEK.QMNSHKVSFERM...LQNER..TLKIQ..AINKLAEVMNRR-v
F6ZBB4_MACMU/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
G1PP69_MYOLU/950-1016              ............................LAKDVELLRKENEELTDKM...R.KSE.E..D...YKLKKEEE-.-ISNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
E4WRQ2_OIKDI/5-49                  ......................akkprh-------------------...-.---.-..-...-----DMKN.QWHEEKTELEKK...LSQEI..LLKKQ..SVNKLVQVMTRK-g
G5B595_HETGA/888-956               ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEL.SATAVKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F6XUQ9_HORSE/948-1014              ............................LTKDIELLRKENEELTDKM...R.KTE.E..E...YKLKKEEE-.-ISNLKAAYEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H0ZJ44_TAEGU/920-986               ............................LTKDVDLITKENTEISEKF...K.KQE.E..D...YKMKKEEE-.-ISNIRMHYEKS...INTER..TLKTQ..AVNKLAEIMNRKD.
Q5SP95_DANRE/8-76                  ............................LTVDVANLASEKEELNNKL...K.HIQ.Q..K...LEKIKEEEK.QMKSLTVSYEKQ...IQVEK..TLKIQ..AINKLAEVMKKTD.
F7IR26_CALJA/948-1014              ............................LTKDIEILRRENEELTEKM...K.RTE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G3WFV9_SARHA/942-1010              ............................LTSDVANLANEKEELNNKV...K.EVQ.E..Q...ISRLKDEET.NISVIKTQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
D9ZGF8_HUMAN/948-1014              ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H2P6Y3_PONAB/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
G3PH56_GASAC/927-995               ............................LTSDVANLANEKEELNNKL...K.EAM.E..E...SEKSKDWEQ.QISQMKQSFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
H3C5G4_TETNG/963-1031              ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAREAER.QMNSLKVSFERL...LQNER..TLKIQ..AVNKLAEVMNRR-v
Q29IT7_DROPS/935-1000              ............................LHKKLGQKANEYEDLVQQH...K.KQQ.D..E...LGQLRATK-.-DEEITKLLDKC...-KTEV..LLKQV..AVNKLAEVMNRRD.
H3B2B3_LATCH/954-1020              ............................LTKDVDNLAKEKAELDEKL...K.KKE.E..E...YQTQKEET-.-ISNIKASYEKI...LNTER..TLKTQ..AVNKLAEIMNRKD.
B7Q4S9_IXOSC/844-916               ............................LEKDRAVRDLELEQLHKQLvseRsSHE.S..A...LEQERAERA.AEAARQEQLQKQ...LHQER..LLKQV..AVNKLAEVMNRKD.
H2TR74_TAKRU/961-1029              ............................LTSDVANLANEKEELNNKL...K.AAI.E..E...SQKSNDWEQ.QICQMKQGFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
B4HAM7_DROPE/950-1015              ............................LHKKLGQKANEYEDLVQQH...K.KQQ.D..E...LGQLRATK-.-DEEITKLLEKC...-KTEV..LLKQV..AVNKLAEVMNRRD.
H3D439_TETNG/978-1046              ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAREAER.QMNSLKVSFERL...LQNER..TLKIQ..AVNKLAEVMNRR-v
H2QEB3_PANTR/948-1014              ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H2YZC7_CIOSA/961-1029              ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
G3P4V5_GASAC/882-950               ............................LTVDAANLASEKEELNNQL...K.NTQ.Q..Q...LLKAREEEK.QMNSLQLSFEKQ...LQNER..TLKIQ..AINKLAEVMNRRD.
G1RV80_NOMLE/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2UA40_TAKRU/956-1022              ............................LTKDAENLSKEKAELNEKL...Q.TQE.Q..E...YVDQKEDI-.-VNAVKANYEKV...LNTER..TLKTQ..AVNKLAEIMNRKD.
H3B7E7_LATCH/973-1041              ............................LTSDVANLANEKEELNNKL...K.ETH.E..Q...IQKMKDEEL.NIAVIKTQYDKQ...LLNER..TLKTQ..AVNKLAEIMNRKD.
F1R417_DANRE/973-1041              ............................LTVDVANLASEKEELNNKL...K.HIQ.Q..K...LEKIKEEEK.QMKSLTVSYEKQ...IQVEK..TLKIQ..AINKLAEVMKKTD.
Q4S6S5_TETNG/1049-1117             ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAREAER.QMNSLKVSFERL...LQNER..TLKIQ..AVNKLAEVMNRR-v
F6R6H8_CIOIN/1036-1104             ............................LESQMEEMKKEKEGWMKKV...D.AAN.E..E...IENLKQTSG.EVAALKASYEKT...LNQEK..MLKMQ..AVNKLAEIMNRKQ.
F1PE53_CANFA/936-1004              ............................LTSDVANLANEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1NK88_CHICK/935-1005              ............................LTSDVANLANEKEELNNKL...K.EEQ.E..Q...ITKLKEEEA.NIGNIKAQFEKQ...LLNER..TLKTQgkAVNKLAEIMNRK-g
F1NMU3_CHICK/923-989               ............................LTKDVDLVTKENSEMSEKM...K.KQE.E..E...YKLKKEEE-.-INNIRMQYEKS...INNER..TLKTQ..AVNKLAEIMNRKD.
Q6A035_MOUSE/367-435               ............................LTSDVANLANEKEELNNKL...K.DSQ.E..Q...LSKLKDEEM.SAAAIKAQFEKQ...LLNER..TLKTQ..AVNKLAEIMNRKE.
H2YZD3_CIOSA/901-970               vqdtnaileqwrshyereivhlqlakve-------------------...-.--N.E..G...ANRQKVSE-.----KNDEIIKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
F1NRH5_CHICK/923-989               ............................LTKDVDLVTKENSEMSEKM...K.KQE.E..E...YKLKKEEE-.-INNIRMQYEKS...INNER..TLKTQ..AVNKLAEIMNRKD.
G3TF10_LOXAF/948-1014              ............................LTRDIELLRKENEELTENM...R.KTE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
B4M9X3_DROVI/952-1017              ............................LHKKLKQKASEWDELLVQH...K.KQL.D..E...LQQQRAAK-.-DEEIAKLGEKC...-KNEV..LLKQV..AVAKLAEVMNRRD.
F8W847_HUMAN/336-404               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F6RG19_CALJA/895-964               ............................LTSDVANLANEKEELNNKL...K.RCSiS..E...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F6T5Y1_MACMU/917-983               ............................LTKDMEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
Q961D4_DROME/962-1027              ............................LHKKLGQKAAEYEDLVQQH...K.KQQ.E..E...LALMRSSK-.-DEEITKLLDKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
Q3TBE0_MOUSE/110-176               ............................LTKDIEMLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-INNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
A7SW93_NEMVE/1-28                  ...........................a-------------------...-.---.-..-...---------.--------LKKS...LHIER..TLKIQ..AVNKLAEIMNRKD.
ROCK1_BOVIN/355-421                ............................LTKDIELLRKENEELTDKM...R.KAE.E..E...YKLKKEEE-.-INILKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H2MVL7_ORYLA/631-699               ............................LTSDVANLANEKEELNCKL...K.EAL.E..E...SEKSKDWEQ.QISQMKQGFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
H0X6A1_OTOGA/944-1010              ............................LTKDIELLRKENEELTEKM...K.RAE.E..D...YKLKKEEE-.-IGNLKAAYEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
G3HB11_CRIGR/661-729               ............................LTSDVANLANEKEELNNKL...K.DTQ.E..Q...LLKLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
D3ZN37_RAT/460-526                 ............................LTKDIELLRKENEELNERM...R.TAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...ISTER..TLKTQ..AVNKLAEIMNRKD.
Q14DU5_HUMAN/293-361               ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2MVL9_ORYLA/605-673               ............................LTSDVANLANEKEELNCKL...K.EAL.E..E...SEKSKDWEQ.QISQMKQGFEKQ...LQSER..TLKTQ..AVNKLAEIMNRKE.
E9GLV2_DAPPU/955-1020              ............................LKKTFDLVTQENQDLGAKL...K.SAQ.E..E...LAQASTAS-.-VDEVE-RLRVK...LKQEQ..LLKMQ..AVNKLAEIMNRKD.
G3U5Y3_LOXAF/890-956               ............................LTRDIELLRKENEELTENM...R.KTE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
Q9U779_DROME/962-1027              ............................LHKKLGQKAAEYEDLVQQH...K.KQQ.E..E...LALMRSSK-.-DEEITKLLDKC...-KNEV..LLKQV..AVNKLAEVMNRRD.
Q179S5_AEDAE/888-952               ...........................m-NKKLNNKAFELDDLTQQN...R.KMQ.D..E...LSVLKSEQS.EMEKLRT----K...LKTET..MLKQQ..AVNKLAEIMNRKD.
ROCK1_HUMAN/948-1014               ............................LTKDIEILRRENEELTEKM...K.KAE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
#=GR ROCK1_HUMAN/948-1014    SS    ............................HHHHHHHHHHHHHHHHHHH...H.HHH.H..H...HHHHHHHH-.-HHCHHHHHHHC...HHHHH..HHHHH..HHHHHHHHHHTT-.
H0VGZ3_CAVPO/948-1014              ............................LTKDNELLRKENEELMDKM...K.KAE.E..E...YKLKKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
B0WWT9_CULQU/951-1015              ............................LSKKLNNKLFELDDLAQQN...R.KMQ.D..E...LGQLKSEQA.EMEKLRT----K...LKTET..MLKQQ..AVNKLAEIMNRKD.
G1TY77_RABIT/948-1016              ............................LTGDVANLASEKEELNNKL...K.DAQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
G1KHH5_ANOCA/950-1016              ............................LTKDVAFLTKENSELNEKV...K.KLE.E..D...YKLKTEEE-.-ISIIRMQYEKN...LNNER..TLKTQ..AVNKLAEIMNRKD.
G3U660_LOXAF/934-1002              ............................LTSDVANLANEKEELNNKL...K.DAQ.D..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F1MF50_BOVIN/961-1027              ............................LTKDIELLRKENEELTDKM...R.KAE.E..E...YKLKKEEE-.-INILKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H9G236_MACMU/978-1046              ............................LTSDVANLANEKEELNNKL...K.DVQ.E..Q...LSRLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
H2VBN1_TAKRU/614-682               ............................LTVDVANLAGEKEELNNQL...K.EMQ.Q..K...LQKAKEAEK.QMNSHKVSFERM...LQNER..TLKIQ..AINKLAEVMNRR-v
H2YZC6_CIOSA/961-1029              ............................LETQVEDIRKEKETWSKKL...E.SAN.E..E...IEALKQTAL.QVATMKAGYEKS...LNQEK..MLKLQ..AVNKLAEILNRKQ.
G3WNF9_SARHA/110-176               ............................LTKDIELLRKENEEFTEKM...R.KEQ.E..D...YKLKKEEE-.-INNLKASFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
H9K8V1_APIME/942-1006              ............................LKKNVDQYLKEKEDLNKRF...K.ELQ.D..Q...LSKAQSNAE.EIEKL----SSK...LKTEQ..LLKQQ..AVNKLAEIMNRKD.
ROCK2_RAT/978-1046                 ............................LTSDVANLANEKEELNNKL...K.DTQ.E..Q...LSKLKDEEI.SAAAIKAQFEKQ...LLTER..TLKTQ..AVNKLAEIMNRKE.
F7INR3_CALJA/64-130                ............................LTKDIEILRRENEELTEKM...K.RTE.E..E...YKLEKEEE-.-ISNLKAAFEKN...INTER..TLKTQ..AVNKLAEIMNRKD.
F6R6F3_CIOIN/950-1018              ............................LESQMEEMKKEKEGWMKKV...D.AAN.E..E...IENLKQTSG.EVAALKASYEKT...LNQEK..MLKMQ..AVNKLAEIMNRKQ.
#=GC SS_cons                       ............................HHHHHHHHHHHHHHHHHHH...H.HHH.H..H...HHHHHHHHH.HHHCHHHHHHHC...HHHHH..HHHHH..HHHHHHHHHCTT-.
#=GC seq_cons                      ............................LTpDltpLspEKEELspKh...K.csp.E..c...hpthK-EE...hsslKApaEKp...LpoER..TLKTQ..AVNKLAEIMNRK-.
//
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