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Database: Pfam
Entry: Rota_NSP3
LinkDB: Rota_NSP3
Original site: Rota_NSP3 
#=GF ID   Rota_NSP3
#=GF AC   PF01665.14
#=GF DE   Rotavirus non-structural protein NSP3
#=GF AU   Bashton M, Bateman A
#=GF SE   Pfam-B_1010 (release 4.1)
#=GF GA   25.00 25.00;
#=GF TC   29.30 445.20;
#=GF NC   23.90 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7871749
#=GF RT   Comparative nucleotide and amino acid sequence analysis of the
#=GF RT   sequence- specific RNA-binding rotavirus nonstructural protein
#=GF RT   NSP3. 
#=GF RA   Rao CD, Das M, Ilango P, Lalwani R, Rao BS, Gowda K; 
#=GF RL   Virology 1995;207:327-333.
#=GF RN   [2]
#=GF RM   1326821
#=GF RT   Characterization of an oligomerization domain and RNA-binding
#=GF RT   properties on rotavirus nonstructural protein NS34. 
#=GF RA   Mattion NM, Cohen J, Aponte C, Estes MK; 
#=GF RL   Virology 1992;190:68-83.
#=GF RN   [3]
#=GF RM   9755181
#=GF RT   Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and
#=GF RT   evicts the poly(A) binding protein from eIF4F. 
#=GF RA   Piron M, Vende P, Cohen J, Poncet D; 
#=GF RL   EMBO J 1998;17:5811-5821.
#=GF DR   INTERPRO; IPR002873;
#=GF DR   SCOP; 1knz; fa;
#=GF CC   This family consist of rotaviral non-structural RNA binding
#=GF CC   protein 34 (NS34 or NSP3). The NSP3 protein has been shown to
#=GF CC   bind viral RNA.  The NSP3 protein consists of 3 conserved
#=GF CC   functional domains; a basic region which binds ssRNA, a region
#=GF CC   containing heptapeptide repeats mediating oligomerisation and a
#=GF CC   leucine zipper motif [2]. NSP3 may play a central role in
#=GF CC   replication and assembly of genomic RNA structures [2].
#=GF CC   Rotaviruses have a dsRNA genome and are a major cause cause of
#=GF CC   acute gastroenteritis in the young of many species [1]. The
#=GF CC   rotavirus non-structural protein NSP3 is a sequence-specific RNA
#=GF CC   binding protein that binds the nonpolyadenylated 3' end of the
#=GF CC   rotavirus mRNAs. NSP3 also interacts with the translation
#=GF CC   initiation factor eIF4GI and competes with the poly(A) binding
#=GF CC   protein [3].
#=GF SQ   2
#=GS NSP3_ROTHC/1-299  AC Q9PY95.1
#=GS NSP3_ROTSH/5-286  AC A2T3N5.1
NSP3_ROTHC/1-299             MATQASVEWIFNVAGSAASSSLDKAIKDAGGSENFSKYVITKFYDNYKDCIDDSGVYNACIGRAKTIDKALNDP.KVAERNEEWYTNVATISRLDLELAELKLMLSNLGIKREERVLNSMFSVVREKGRSSNVIMMKQNAVKMIEEGKLKIK....VERNETYTESLKNKIEELECIIDAF.....EKGKDITIDLDAMNGEVKLDGNSCSYNSTAALVSTILGTPIKMYNESGQPLFD..VGNYMNPKNIIEKMIELEIPIFKSDYRNNESPDFDSWNERSNLKIVSVNDCHAICIFKFENNWWCFDDGR.........
NSP3_ROTSH/5-286             ESTQQMAVSIINSSFEAAVVAATSALENMGIEYDYQD-IYSRVKNKFDFVMDDSGVKNNLIGKAITIDQALNNKfGSAIRNRNWLADTSRAAKLDEDVNKLRMMLSSKGIDQKMRVLNACFSVKRIPGKSSSIIKCTKLMRDKLERGEVEVDdsfvDEKMEVDTIDWKSRYEQLEQRFESLksrvnEKYNNWVLKARKMNENMHSLQNVISQQQAHI-------AELQVYNNKLERDLQnkIGSLTSSIEWYLRSMELD-PEIKADI------------EQQINSIDAINPLHA-----------------fddlesvir
#=GC seq_cons                .uTQt.s..IhNsuhpAAssuhspAlcshGhp.sapc.lho+hhspac.shDDSGVhNshIG+AhTIDpALNs..tsA.RNcpWhsssuphu+LD.-lscL+hMLSshGIcpc.RVLNuhFSVhR..G+SSslIhhpp.hhchlEcGclclc....sE+.Es.T.shKs+hEpLEphh-uh.....EKhpshslchctMNtph+..tNshS.ppsth.......s.lphYNpphp..hp..lGshhsshphh.+.hEL-.P.hKuDh............Epp..pIsulNshHA..........................
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