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Database: Pfam
Entry: SOR
LinkDB: SOR
Original site: SOR 
#=GF ID   SOR
#=GF AC   PF07682.6
#=GF DE   Sulphur oxygenase reductase
#=GF AU   Kletzin A, Studholme DJ
#=GF SE   [4]
#=GF GA   25.00 25.00;
#=GF TC   191.60 191.40;
#=GF NC   22.80 16.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   2493451
#=GF RT   Coupled enzymatic production of sulfite, thiosulfate, and
#=GF RT   hydrogen sulfide from sulfur: purification and properties of a
#=GF RT   sulfur oxygenase reductase from the facultatively anaerobic
#=GF RT   archaebacterium Desulfurolobus ambivalens. 
#=GF RA   Kletzin A; 
#=GF RL   J Bacteriol 1989;171:1638-1643.
#=GF RN   [2]
#=GF RM   11111027
#=GF RT   Cloning and heterologous expression of a sulfur
#=GF RT   oxygenase/reductase gene from the thermoacidophilic archaeon
#=GF RT   Acidianus sp. S5 in Escherichia coli. 
#=GF RA   He Z, Li Y, Zhou P, Liu S; 
#=GF RL   FEMS Microbiol Lett 2000;193:217-221.
#=GF RN   [3]
#=GF RM   12664265
#=GF RT   Purification and properties of the sulfur oxygenase/reductase
#=GF RT   from the acidothermophilic archaeon, Acidianus strain S5. 
#=GF RA   Sun CW, Chen ZW, He ZG, Zhou PJ, Liu SJ; 
#=GF RL   Extremophiles 2003;7:131-134.
#=GF RN   [4]
#=GF RM   15030315
#=GF RT   The sulphur oxygenase reductase from Acidianus ambivalens is a
#=GF RT   multimeric protein containing a low-potential mononuclear
#=GF RT   non-haem iron centre. 
#=GF RA   Urich T, Bandeiras TM, Leal SS, Rachel R, Albrecht T, Zimmermann
#=GF RA   P, Scholz C, Teixeira M, Gomes CM, Kletzin A; 
#=GF RL   Biochem J 2004; [Epub ahead of print]
#=GF DR   INTERPRO; IPR011661;
#=GF CC   The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic
#=GF CC   archaeon Acidianus ambivalens is an unusual enzyme consisting of
#=GF CC   24 identical subunits arranged in a perfectly symmetrical hollow
#=GF CC   sphere and containing a mononuclear non-heme iron centre
#=GF CC   (personal communication: A. Kletzin). At 85 degrees C in vitro,
#=GF CC   elemental sulphur is oxidised to sulphite, thiosulphate and
#=GF CC   hydrogen sulphide with no external cofactors needed. The
#=GF CC   proposed equation is:  4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2
#=GF CC   H+.
#=GF SQ   21
#=GS A4ZIS7_SULME/2-304   AC A4ZIS7.1
#=GS D0L035_HALNC/4-310   AC D0L035.1
#=GS Q6L0W6_PICTO/2-302   AC Q6L0W6.1
#=GS Q977W3_9CREN/2-304   AC Q977W3.1
#=GS Q977W3_9CREN/2-304   DR PDB; 3BXV A; 2-304;
#=GS C7LRC9_DESBD/9-307   AC C7LRC9.1
#=GS B1PHD8_9ARCH/1-276   AC B1PHD8.1
#=GS G4DJV8_9GAMM/15-308  AC G4DJV8.1
#=GS Q972K4_SULTO/2-304   AC Q972K4.1
#=GS B1PHE3_9ARCH/1-276   AC B1PHE3.1
#=GS B1PHD9_9ARCH/1-276   AC B1PHD9.1
#=GS G8TY32_9FIRM/2-302   AC G8TY32.1
#=GS B1PHE0_9ARCH/1-276   AC B1PHE0.1
#=GS O66762_AQUAE/7-333   AC O66762.1
#=GS G0JQP4_9GAMM/3-307   AC G0JQP4.1
#=GS F4B4D5_ACIHW/1-295   AC F4B4D5.1
#=GS C6NWI4_9GAMM/3-307   AC C6NWI4.1
#=GS F8I6C7_SULAT/2-302   AC F8I6C7.1
#=GS B1PHE2_9ARCH/1-276   AC B1PHE2.1
#=GS SOR_ACIAM/2-304      AC P29082.3
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV B; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW F; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV A; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 E; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX C; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW E; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 C; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW A; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW D; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX E; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV D; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW C; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV C; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX B; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 D; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV F; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX F; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 F; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAW B; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 B; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2CB2 A; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX D; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAV E; 2-304;
#=GS SOR_ACIAM/2-304      DR PDB; 2YAX A; 2-304;
#=GS B1PHE1_9ARCH/1-276   AC B1PHE1.1
#=GS A3QSJ9_9BACT/2-302   AC A3QSJ9.1
A4ZIS7_SULME/2-304              ..PKPYVAINQVIVKNEPKTFEMFQSVGPKVCMTTARHKGFVGFQNHIEIGVVPMGTRYGAAKMDMLKESS.............TMGLYQYTMWKDWKDHEEMHKQNWSSLFRLCYSCMSQVVWGPWEPLYEITMADMPLNTEMTDFTVMVGQKFASGD..ALSLPPISQPYGKRVVTYGEHVVKEGMEKEFEETLSRLLPMFKR.APGFLGYMVLKEIGASPLGSLQLSAKSWHQLL..ESANGMDVPDPNGN....FSP..EQAR.....NKPQKYVVHMEWSNTDAAQFGLGRVFLSPEYREIHD.QIVDTLIY.GPYIRILNPVMEGSFWRE.
D0L035_HALNC/4-310              .e-NPIIAINMAKIANKPDSYETMMKVGPKVCITTASHPGFLGFEQLLQTGIHPMAGRYGGGAVDMRETLN.............PMGMFQYTVWKDVHSHEEMHHDNFKEIFELCSGCLGMVIEGPWEPYFEVVKSDLPQIMSMTDVPQVLGDSFAKQE..--RVPKVAL-SSQRTVVIGDHWVMDGHEKAFEQGATETLEWMKAnVPGMVGWMIMKQFGVSAIGSFQLDPEGAMKAV..STLGANPPEYNTNYgnkvHDK..PPIP....gQTPTQYLVHIEWESPEHAHQGLGHVMVDYELRQIHNnGVLAHLDK.GPYYMFFSPMMEQGLWR-k
Q6L0W6_PICTO/2-302              ..PKPYVAINIVEMLNNETTMNMFQQVGPKVCMVTARHPGFVGFQNHVQFGVIPLGTRYGGASMDMTK-MS.............TMNVYQYTMWKNIKDHEDMHRENFSSIFRLCSSCLSQVVYGPWEPLFEIVDADMPLNTDMMDFTVMFGKKFAAGD..PSGVPPISQPYGRRTIALSEHTVKKGMEKDFESNIVEVMKDFRN.APGFLGYMILKEVGVSAVGSFQLKSQGIHEAL..ESNGEVPQH-QEGA....FSY..EEAR.....PTPPEYFVHMEWATPQDAQFGIARVLFKHETRVLHD.KVLDTLIK.GPYIRLLNPMMEGTSWRE.
Q977W3_9CREN/2-304              ..PKPYIAINMADLKNEPKTFEMFSAVGPKVCMVTARHPGFVGFQNHVQIGVLPFGERFGGAKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPINTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVVAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANLDALQFGMGRVLLSPEYREVHD.EALDTLIY.GPYIRIINPVMEGTFWRE.
#=GR Q977W3_9CREN/2-304   SS    ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHTTGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHGGG.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..H--SSS---GGG--....S-G..GGG-.....-SS-EEEEEEEESSHHHHHHHHTHHHH-HHHHHHHH.HHHTSEEE.EEEEEEEEEEEEETTHHH.
C7LRC9_DESBD/9-307              sp--IYVALNMSKVVNNEESFDLMHKVGPRVCITTATHPGFLGFMANIQTGILPLAGRYGGGSTHMENALN.............PVRNYQYTMWKHWKDHDEFHEKQFSRIFELCTSCLEMVVEGPWEPVYSVIHAKMPTVRSMGQIAD-LGKDFVQQK..D----FIRFATPQRCVAIGEHTVAPGKEKAFEKGAIETMEALSD.ATGFLGYMILKQIGVCALGSFMLDPTSMAETL..QTLGANPPKKPRPL....FKT..LDAM.....PRPPEYLIHSEWDATEMAQMGFAKVLVNHAIRKIHDdGVMAHLIR.GPYIMFFQPMMEEPGWR-s
B1PHD8_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHVQIGVLPFGERFGGTKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPMNTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVVAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANPDALQFGMGRVLLSPEYRHVHD.EAVDALIY.GPYIRIINPIMEGTFWRE.
G4DJV8_9GAMM/15-308             sp--LYVAINRVLVENNPNLMRMMRQASSEMCLATALTPGFRGFDLMRQTGSCPMGMRWGA-STDMAQELS.............HIWIDQFTYWDSLEAHEEFHETFEDVVVTACDKCGNVLLDGPEEPVYRIVKSQLPRLVSMNQFEQ------ARAE..GRDIGQLAVDSGQTVTVLATHIVRPGREGEFEEGEIRTLDLLRQ.SNGMIGYQILKRVGISTLGSGHATV---ESIM..ERMKGTPGAKLERT....AEV..WEGY.....TIPAEYVVMVEWESLHAAQRGMPHVNVKPDILFVHGpKVFNNCVR.MPTVRMAVSMFAEQTYR-e
Q972K4_SULTO/2-304              ..PKPYVAINMVEVRNDPKTLELFGKVGPKVCMVTARHPGFVGFQNHVQIGVVPLGTRWGGAKMEMSQEMH.............SLMLMQYTFWKNWKDHEEMHKQNWANLFRLCLQCADQMIWGPYEPLYEIVYANMPLNTEMTDFTVMVGKKFAAGE..AVSIPPISQPYGKRVVAFGEHIVKEGLENQFEEYAIKTLEAFRS.APGFLGGMILKEIGVSPLGSLQLNAKGFHQIL..ETANGMDVPEPVTI....YEA..PEFR.....NRPQRYIVHTEWSDTNALMFGLGRVLIYPEVRQIHD.KVLDTLVY.GPYIRVLNPMMEGTYWRE.
B1PHE3_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQLL..ENPGSLEPDPNSVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFRMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
B1PHD9_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHVQIGVLPFGERFGGAKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPINTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVEAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANLDALQFGMGRVLLSPEYREVHD.EALDTLIY.GPYIRIINPVMEGTFWRE.
G8TY32_9FIRM/2-302              .p-VPYIAVNKARVLNAPSSFETFTSVGPKVCMVTANHEGFVGFQNHVQVGVFPMGGRYGAAKMDMHEELN.............PIGIVQYTMWRHWEDHEAMHYENFDSIFRLCSQCLNMVVEGPWEPLYEIVAHDLPENVSMTDVPAALGAAWMAGQ..P--VPAVSLPYGQRIVAASDHTVIPGREKDFEQAIVDVMTAFKK.APGFLGYMVMKQIGASAIGAMQLTPQGIHQAL..QTRGDNPPRDKEGN....FQP..MQAH.....SSPQEYVVHMEWADMNSAMMGISRVVVNHKMRMIHD.RVLETVLK.GPYVTLWNPIMEDTSWRE.
B1PHE0_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............TVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
O66762_AQUAE/7-333              ..KGVAVAINKAKVNNTPRFQELMYQVGPKVCITTAMHEGFLGFHAFIQVGAHPLGGRFGAAKVINADSLEaiqregltaikynPLELWQYTVWEKWEDHEEMHYQQFDRIFELCVGCFTEVVEGPNEPIYVVREANMPPVIDFTDVPKVLGESMMQAMqgKGGIPKVRL-LTQRIAVVGIHKVKEGMEEKFIEGAVETLELLNKySAGMIGWMILEKIGESPYGTFQIKPPEFWEVV..ASRGAVPPKTRETIw.geYGK..PEFQle.paGHPKEFIVHMEWSRPESAMFGPALTAVNPKIKKVHDeKVMTTLAHiPPYYKVFMPLMEDLILFP.
G0JQP4_9GAMM/3-307              ..KNPIIAINQAKIFNRPESHEIMMKVGPKVCITTANHPGFLGFEQLIQTGIHPMAGRYGGGSVDMRETLN.............PIAMYQYTVWKDVHSHEEMHHDNFDTIYELCGSCLDMVIEGPWEVYYEIIKSDLPPIMGITDVPTILGDAFAKQQ..--PVPKVAL-AEQRAITVGDHWVMKGHEQDFEVGVIKTLEWLKAsVPGMIGWMILKQTGASAIGSFQLDPEGMLK--..ATLGANPPKY-NTN....YGSkiPT-QppipaQTPAQYLIHMEWESPAHAHTGLGYVMVDYDLRQIHNnGVLQHLDK.GPYYMFFAPMMEQGMWR-k
F4B4D5_ACIHW/1-295              ..--------MAELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
C6NWI4_9GAMM/3-307              ..KNPIVAINQSKVVNRPESFATMMKVGPKVCITTASHPGFLGFEQLLQTGMHPMAGRYGGGAVDMRDTIN.............PMAMYQYTVWQDVKSHEEMHHDNFKEIYELCGSCLDMVIEGPWEPYYEIVRSDLPRIMGMTDVPAQLGAAFAAQK..PVS--KVAL-ASQRCIALGDHWVSDGHEKDFEKGAVATLTWMKEnIPGMVGWMILKQFGVSAIGSFQLDPEGMMKATlgANPPAYATNHGTAI....PDK..PQIP....gQRPTQYLVHMEWESPEMAHMGIGYAMVDYELRQIHNhGVLAHLDR.GPYYLFFAPMMEQGQWR-r
F8I6C7_SULAT/2-302              .p-VPYIAVNKARVLNAPSSFETFTSVGPKVCMVTANHEGFVGFQNHVQVGVFPMGGRYGAAKMDMHEELN.............PIGIVQYTMWRHWEDHEAMHYENFDSIFRLCSQCLNMVVEGPWEPLYEIVAHDLPENVSMTDVPAALGAAWMAGQ..P--VPAVSLPYGQRIVAASDHTVIPGREKDFEQAIVDVMTAFKK.APGFLGYMVMKQIGASAIGAMQLTPQGIHQAL..QTRGDNPPRDKEGN....FQP..MQAH.....SSPQEYVVHMEWADMNSAMMGISRVVVNHKMRMIHD.RVLETVLK.GPYVTLWNPIMEDTSWRE.
B1PHE2_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHIQIGVLPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPVMEGTFWRE.
SOR_ACIAM/2-304                 ..PKPYVAINMAELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............TVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
#=GR SOR_ACIAM/2-304      SS    ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHGGGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHHTT.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..T--SSS---GGG--....S-T..GGG-.....-BSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHH.HHHTTEEE.EEEEEEEEEEEEETTHHH.
B1PHE1_9ARCH/1-276              ..---------------------------KVCMVTARHPGFVGFQNHIQIGVLPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
A3QSJ9_9BACT/2-302              ..PRPYITINDAKVVNAESSFQAFQQVGPKVCMVTANHPGFVGFQNHVQIGVFPMGGRYGGAKMDMHEELN.............PIGIRQYTMWKRWEDHEEMHYQQFDSIFRLCSSCLGMVVEGPWEDVYEIVSSDLPEVIAMTDVPSKLGAAFMAGQ..QP--APVAMPYGQRVIAGSDHYIIPGREQEFETAITDLMKMFQK.APGFLGYMVLKQIGASAIGSFQLQPEGIHQAL..QTLGDNPPKNKEGN....FKL..IEAK.....KTPTKYLVHMEWMDLNSAMFGISRVVINGRYRAQHD.KALATLVQ.GPYVTLWSPMMEDTSWRE.
#=GC SS_cons                    ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHCCGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHHCC.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..C--SSS---GGG--....S-C..GGG-.....-CSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHH.HHHTTEEE.EEEEEEEEEEEEETTHHH.
#=GC seq_cons                   .....hlAlN.sclhNt.pohphh.pVGPKVCMVTApHPGFVGFQNHlQlGllPhGsRYGGAKMDMscE.s.............sltlhQYThWKDWKDHEEMH+QNauhlFRLChSChuphl.GPWEPlYEIlhAsMPhNs-MTDFsuslGccFApGc..PhslPsIS.PYGpRVVAhuEHoVhPG+EKpFE-uIl+TLEhhK+.APGFLGhMlLKcIGVSuIGShQhsscGhHQlL..EosGuh.Pcssssh....aps..PEA+.....sTPppYlVHhEWuss-uhhFGhGRVllpPElRplHD.cVL-TLlh.GPYIRlhNPMMEsThWRE.
//
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