#=GF ID SOR
#=GF AC PF07682.6
#=GF DE Sulphur oxygenase reductase
#=GF AU Kletzin A, Studholme DJ
#=GF SE [4]
#=GF GA 25.00 25.00;
#=GF TC 191.60 191.40;
#=GF NC 22.80 16.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 2493451
#=GF RT Coupled enzymatic production of sulfite, thiosulfate, and
#=GF RT hydrogen sulfide from sulfur: purification and properties of a
#=GF RT sulfur oxygenase reductase from the facultatively anaerobic
#=GF RT archaebacterium Desulfurolobus ambivalens.
#=GF RA Kletzin A;
#=GF RL J Bacteriol 1989;171:1638-1643.
#=GF RN [2]
#=GF RM 11111027
#=GF RT Cloning and heterologous expression of a sulfur
#=GF RT oxygenase/reductase gene from the thermoacidophilic archaeon
#=GF RT Acidianus sp. S5 in Escherichia coli.
#=GF RA He Z, Li Y, Zhou P, Liu S;
#=GF RL FEMS Microbiol Lett 2000;193:217-221.
#=GF RN [3]
#=GF RM 12664265
#=GF RT Purification and properties of the sulfur oxygenase/reductase
#=GF RT from the acidothermophilic archaeon, Acidianus strain S5.
#=GF RA Sun CW, Chen ZW, He ZG, Zhou PJ, Liu SJ;
#=GF RL Extremophiles 2003;7:131-134.
#=GF RN [4]
#=GF RM 15030315
#=GF RT The sulphur oxygenase reductase from Acidianus ambivalens is a
#=GF RT multimeric protein containing a low-potential mononuclear
#=GF RT non-haem iron centre.
#=GF RA Urich T, Bandeiras TM, Leal SS, Rachel R, Albrecht T, Zimmermann
#=GF RA P, Scholz C, Teixeira M, Gomes CM, Kletzin A;
#=GF RL Biochem J 2004; [Epub ahead of print]
#=GF DR INTERPRO; IPR011661;
#=GF CC The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic
#=GF CC archaeon Acidianus ambivalens is an unusual enzyme consisting of
#=GF CC 24 identical subunits arranged in a perfectly symmetrical hollow
#=GF CC sphere and containing a mononuclear non-heme iron centre
#=GF CC (personal communication: A. Kletzin). At 85 degrees C in vitro,
#=GF CC elemental sulphur is oxidised to sulphite, thiosulphate and
#=GF CC hydrogen sulphide with no external cofactors needed. The
#=GF CC proposed equation is: 4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2
#=GF CC H+.
#=GF SQ 21
#=GS A4ZIS7_SULME/2-304 AC A4ZIS7.1
#=GS D0L035_HALNC/4-310 AC D0L035.1
#=GS Q6L0W6_PICTO/2-302 AC Q6L0W6.1
#=GS Q977W3_9CREN/2-304 AC Q977W3.1
#=GS Q977W3_9CREN/2-304 DR PDB; 3BXV A; 2-304;
#=GS C7LRC9_DESBD/9-307 AC C7LRC9.1
#=GS B1PHD8_9ARCH/1-276 AC B1PHD8.1
#=GS G4DJV8_9GAMM/15-308 AC G4DJV8.1
#=GS Q972K4_SULTO/2-304 AC Q972K4.1
#=GS B1PHE3_9ARCH/1-276 AC B1PHE3.1
#=GS B1PHD9_9ARCH/1-276 AC B1PHD9.1
#=GS G8TY32_9FIRM/2-302 AC G8TY32.1
#=GS B1PHE0_9ARCH/1-276 AC B1PHE0.1
#=GS O66762_AQUAE/7-333 AC O66762.1
#=GS G0JQP4_9GAMM/3-307 AC G0JQP4.1
#=GS F4B4D5_ACIHW/1-295 AC F4B4D5.1
#=GS C6NWI4_9GAMM/3-307 AC C6NWI4.1
#=GS F8I6C7_SULAT/2-302 AC F8I6C7.1
#=GS B1PHE2_9ARCH/1-276 AC B1PHE2.1
#=GS SOR_ACIAM/2-304 AC P29082.3
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV B; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW F; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV A; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 E; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX C; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW E; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 C; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW A; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW D; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX E; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV D; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW C; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV C; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX B; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 D; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV F; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX F; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 F; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAW B; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 B; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2CB2 A; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX D; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAV E; 2-304;
#=GS SOR_ACIAM/2-304 DR PDB; 2YAX A; 2-304;
#=GS B1PHE1_9ARCH/1-276 AC B1PHE1.1
#=GS A3QSJ9_9BACT/2-302 AC A3QSJ9.1
A4ZIS7_SULME/2-304 ..PKPYVAINQVIVKNEPKTFEMFQSVGPKVCMTTARHKGFVGFQNHIEIGVVPMGTRYGAAKMDMLKESS.............TMGLYQYTMWKDWKDHEEMHKQNWSSLFRLCYSCMSQVVWGPWEPLYEITMADMPLNTEMTDFTVMVGQKFASGD..ALSLPPISQPYGKRVVTYGEHVVKEGMEKEFEETLSRLLPMFKR.APGFLGYMVLKEIGASPLGSLQLSAKSWHQLL..ESANGMDVPDPNGN....FSP..EQAR.....NKPQKYVVHMEWSNTDAAQFGLGRVFLSPEYREIHD.QIVDTLIY.GPYIRILNPVMEGSFWRE.
D0L035_HALNC/4-310 .e-NPIIAINMAKIANKPDSYETMMKVGPKVCITTASHPGFLGFEQLLQTGIHPMAGRYGGGAVDMRETLN.............PMGMFQYTVWKDVHSHEEMHHDNFKEIFELCSGCLGMVIEGPWEPYFEVVKSDLPQIMSMTDVPQVLGDSFAKQE..--RVPKVAL-SSQRTVVIGDHWVMDGHEKAFEQGATETLEWMKAnVPGMVGWMIMKQFGVSAIGSFQLDPEGAMKAV..STLGANPPEYNTNYgnkvHDK..PPIP....gQTPTQYLVHIEWESPEHAHQGLGHVMVDYELRQIHNnGVLAHLDK.GPYYMFFSPMMEQGLWR-k
Q6L0W6_PICTO/2-302 ..PKPYVAINIVEMLNNETTMNMFQQVGPKVCMVTARHPGFVGFQNHVQFGVIPLGTRYGGASMDMTK-MS.............TMNVYQYTMWKNIKDHEDMHRENFSSIFRLCSSCLSQVVYGPWEPLFEIVDADMPLNTDMMDFTVMFGKKFAAGD..PSGVPPISQPYGRRTIALSEHTVKKGMEKDFESNIVEVMKDFRN.APGFLGYMILKEVGVSAVGSFQLKSQGIHEAL..ESNGEVPQH-QEGA....FSY..EEAR.....PTPPEYFVHMEWATPQDAQFGIARVLFKHETRVLHD.KVLDTLIK.GPYIRLLNPMMEGTSWRE.
Q977W3_9CREN/2-304 ..PKPYIAINMADLKNEPKTFEMFSAVGPKVCMVTARHPGFVGFQNHVQIGVLPFGERFGGAKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPINTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVVAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANLDALQFGMGRVLLSPEYREVHD.EALDTLIY.GPYIRIINPVMEGTFWRE.
#=GR Q977W3_9CREN/2-304 SS ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHTTGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHGGG.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..H--SSS---GGG--....S-G..GGG-.....-SS-EEEEEEEESSHHHHHHHHTHHHH-HHHHHHHH.HHHTSEEE.EEEEEEEEEEEEETTHHH.
C7LRC9_DESBD/9-307 sp--IYVALNMSKVVNNEESFDLMHKVGPRVCITTATHPGFLGFMANIQTGILPLAGRYGGGSTHMENALN.............PVRNYQYTMWKHWKDHDEFHEKQFSRIFELCTSCLEMVVEGPWEPVYSVIHAKMPTVRSMGQIAD-LGKDFVQQK..D----FIRFATPQRCVAIGEHTVAPGKEKAFEKGAIETMEALSD.ATGFLGYMILKQIGVCALGSFMLDPTSMAETL..QTLGANPPKKPRPL....FKT..LDAM.....PRPPEYLIHSEWDATEMAQMGFAKVLVNHAIRKIHDdGVMAHLIR.GPYIMFFQPMMEEPGWR-s
B1PHD8_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHVQIGVLPFGERFGGTKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPMNTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVVAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANPDALQFGMGRVLLSPEYRHVHD.EAVDALIY.GPYIRIINPIMEGTFWRE.
G4DJV8_9GAMM/15-308 sp--LYVAINRVLVENNPNLMRMMRQASSEMCLATALTPGFRGFDLMRQTGSCPMGMRWGA-STDMAQELS.............HIWIDQFTYWDSLEAHEEFHETFEDVVVTACDKCGNVLLDGPEEPVYRIVKSQLPRLVSMNQFEQ------ARAE..GRDIGQLAVDSGQTVTVLATHIVRPGREGEFEEGEIRTLDLLRQ.SNGMIGYQILKRVGISTLGSGHATV---ESIM..ERMKGTPGAKLERT....AEV..WEGY.....TIPAEYVVMVEWESLHAAQRGMPHVNVKPDILFVHGpKVFNNCVR.MPTVRMAVSMFAEQTYR-e
Q972K4_SULTO/2-304 ..PKPYVAINMVEVRNDPKTLELFGKVGPKVCMVTARHPGFVGFQNHVQIGVVPLGTRWGGAKMEMSQEMH.............SLMLMQYTFWKNWKDHEEMHKQNWANLFRLCLQCADQMIWGPYEPLYEIVYANMPLNTEMTDFTVMVGKKFAAGE..AVSIPPISQPYGKRVVAFGEHIVKEGLENQFEEYAIKTLEAFRS.APGFLGGMILKEIGVSPLGSLQLNAKGFHQIL..ETANGMDVPEPVTI....YEA..PEFR.....NRPQRYIVHTEWSDTNALMFGLGRVLIYPEVRQIHD.KVLDTLVY.GPYIRVLNPMMEGTYWRE.
B1PHE3_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQLL..ENPGSLEPDPNSVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFRMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
B1PHD9_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHVQIGVLPFGERFGGAKMDMTKESS.............TVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPINTEMTDFTAVVGKKFAEGK..PLEIPVISQPYGKRVEAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLL..ESPGSLEPDPNNVM....YQV..PEAK.....PTPPQYIVHVEWANLDALQFGMGRVLLSPEYREVHD.EALDTLIY.GPYIRIINPVMEGTFWRE.
G8TY32_9FIRM/2-302 .p-VPYIAVNKARVLNAPSSFETFTSVGPKVCMVTANHEGFVGFQNHVQVGVFPMGGRYGAAKMDMHEELN.............PIGIVQYTMWRHWEDHEAMHYENFDSIFRLCSQCLNMVVEGPWEPLYEIVAHDLPENVSMTDVPAALGAAWMAGQ..P--VPAVSLPYGQRIVAASDHTVIPGREKDFEQAIVDVMTAFKK.APGFLGYMVMKQIGASAIGAMQLTPQGIHQAL..QTRGDNPPRDKEGN....FQP..MQAH.....SSPQEYVVHMEWADMNSAMMGISRVVVNHKMRMIHD.RVLETVLK.GPYVTLWNPIMEDTSWRE.
B1PHE0_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............TVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
O66762_AQUAE/7-333 ..KGVAVAINKAKVNNTPRFQELMYQVGPKVCITTAMHEGFLGFHAFIQVGAHPLGGRFGAAKVINADSLEaiqregltaikynPLELWQYTVWEKWEDHEEMHYQQFDRIFELCVGCFTEVVEGPNEPIYVVREANMPPVIDFTDVPKVLGESMMQAMqgKGGIPKVRL-LTQRIAVVGIHKVKEGMEEKFIEGAVETLELLNKySAGMIGWMILEKIGESPYGTFQIKPPEFWEVV..ASRGAVPPKTRETIw.geYGK..PEFQle.paGHPKEFIVHMEWSRPESAMFGPALTAVNPKIKKVHDeKVMTTLAHiPPYYKVFMPLMEDLILFP.
G0JQP4_9GAMM/3-307 ..KNPIIAINQAKIFNRPESHEIMMKVGPKVCITTANHPGFLGFEQLIQTGIHPMAGRYGGGSVDMRETLN.............PIAMYQYTVWKDVHSHEEMHHDNFDTIYELCGSCLDMVIEGPWEVYYEIIKSDLPPIMGITDVPTILGDAFAKQQ..--PVPKVAL-AEQRAITVGDHWVMKGHEQDFEVGVIKTLEWLKAsVPGMIGWMILKQTGASAIGSFQLDPEGMLK--..ATLGANPPKY-NTN....YGSkiPT-QppipaQTPAQYLIHMEWESPAHAHTGLGYVMVDYDLRQIHNnGVLQHLDK.GPYYMFFAPMMEQGMWR-k
F4B4D5_ACIHW/1-295 ..--------MAELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
C6NWI4_9GAMM/3-307 ..KNPIVAINQSKVVNRPESFATMMKVGPKVCITTASHPGFLGFEQLLQTGMHPMAGRYGGGAVDMRDTIN.............PMAMYQYTVWQDVKSHEEMHHDNFKEIYELCGSCLDMVIEGPWEPYYEIVRSDLPRIMGMTDVPAQLGAAFAAQK..PVS--KVAL-ASQRCIALGDHWVSDGHEKDFEKGAVATLTWMKEnIPGMVGWMILKQFGVSAIGSFQLDPEGMMKATlgANPPAYATNHGTAI....PDK..PQIP....gQRPTQYLVHMEWESPEMAHMGIGYAMVDYELRQIHNhGVLAHLDR.GPYYLFFAPMMEQGQWR-r
F8I6C7_SULAT/2-302 .p-VPYIAVNKARVLNAPSSFETFTSVGPKVCMVTANHEGFVGFQNHVQVGVFPMGGRYGAAKMDMHEELN.............PIGIVQYTMWRHWEDHEAMHYENFDSIFRLCSQCLNMVVEGPWEPLYEIVAHDLPENVSMTDVPAALGAAWMAGQ..P--VPAVSLPYGQRIVAASDHTVIPGREKDFEQAIVDVMTAFKK.APGFLGYMVMKQIGASAIGAMQLTPQGIHQAL..QTRGDNPPRDKEGN....FQP..MQAH.....SSPQEYVVHMEWADMNSAMMGISRVVVNHKMRMIHD.RVLETVLK.GPYVTLWNPIMEDTSWRE.
B1PHE2_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHIQIGVLPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPVMEGTFWRE.
SOR_ACIAM/2-304 ..PKPYVAINMAELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKESS.............TVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
#=GR SOR_ACIAM/2-304 SS ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHGGGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHHTT.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..T--SSS---GGG--....S-T..GGG-.....-BSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHH.HHHTTEEE.EEEEEEEEEEEEETTHHH.
B1PHE1_9ARCH/1-276 ..---------------------------KVCMVTARHPGFVGFQNHIQIGVLPFGNRYGGAKMDMTKESS.............SVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGK..PLDIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVL..ENPGSLEPDPNNVM....YSV..PEAK.....NTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD.EVLDTLVY.GPYIRILNPMMEGTFWRE.
A3QSJ9_9BACT/2-302 ..PRPYITINDAKVVNAESSFQAFQQVGPKVCMVTANHPGFVGFQNHVQIGVFPMGGRYGGAKMDMHEELN.............PIGIRQYTMWKRWEDHEEMHYQQFDSIFRLCSSCLGMVVEGPWEDVYEIVSSDLPEVIAMTDVPSKLGAAFMAGQ..QP--APVAMPYGQRVIAGSDHYIIPGREQEFETAITDLMKMFQK.APGFLGYMVLKQIGASAIGSFQLQPEGIHQAL..QTLGDNPPKNKEGN....FKL..IEAK.....KTPTKYLVHMEWMDLNSAMFGISRVVINGRYRAQHD.KALATLVQ.GPYVTLWSPMMEDTSWRE.
#=GC SS_cons ..---EEEEEEEEEE-SHHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT-S.............EEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHCCGGGEEEEEE-EEEEEEEEE------TTTHHHHHHHHHHTT-..GGG-------SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHHCC.STTEEEEEEEEEEEE-TTTTT---HHHHHHHH..C--SSS---GGG--....S-C..GGG-.....-CSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHH.HHHTTEEE.EEEEEEEEEEEEETTHHH.
#=GC seq_cons .....hlAlN.sclhNt.pohphh.pVGPKVCMVTApHPGFVGFQNHlQlGllPhGsRYGGAKMDMscE.s.............sltlhQYThWKDWKDHEEMH+QNauhlFRLChSChuphl.GPWEPlYEIlhAsMPhNs-MTDFsuslGccFApGc..PhslPsIS.PYGpRVVAhuEHoVhPG+EKpFE-uIl+TLEhhK+.APGFLGhMlLKcIGVSuIGShQhsscGhHQlL..EosGuh.Pcssssh....aps..PEA+.....sTPppYlVHhEWuss-uhhFGhGRVllpPElRplHD.cVL-TLlh.GPYIRlhNPMMEsThWRE.
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