GenomeNet

Database: Pfam
Entry: SR-25
LinkDB: SR-25
Original site: SR-25 
#=GF ID   SR-25
#=GF AC   PF10500.4
#=GF DE   Nuclear RNA-splicing-associated protein
#=GF AU   Buljan M, Coggill P
#=GF SE   TreeFam_TF105478
#=GF GA   55.00 55.00;
#=GF TC   55.50 55.40;
#=GF NC   44.10 50.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10708573
#=GF RT   Molecular cloning and expression analysis of a putative nuclear
#=GF RT   protein, SR-25. 
#=GF RA   Sasahara K, Yamaoka T, Moritani M, Tanaka M, Iwahana H,
#=GF RA   Yoshimoto K, Miyagawa J, Kuroda Y, Itakura M; 
#=GF RL   Biochem Biophys Res Commun. 2000;269:444-450.
#=GF RN   [2]
#=GF RM   17952876
#=GF RT   Dominant negative Rac1 attenuates paclitaxel-induced apoptosis
#=GF RT   in human melanoma cells through upregulation of heat shock
#=GF RT   protein 27: a functional proteomic analysis. 
#=GF RA   Lee SC, Sim N, Clement MV, Yadav SK, Pervaiz S; 
#=GF RL   Proteomics. 2007;7:4112-4122.
#=GF DR   INTERPRO; IPR019532;
#=GF CC   SR-25, otherwise known as ADP-ribosylation factor-like factor
#=GF CC   6-interacting protein 4, is expressed in virtually all tissues.
#=GF CC   At the N-terminus there is a repeat of serine-arginine (SR
#=GF CC   repeat), and towards the middle of the protein there are
#=GF CC   clusters of both serines and of basic amino acids. The presence
#=GF CC   of many nuclear localisation signals strongly implies that this
#=GF CC   is a nuclear protein that may contribute to RNA splicing [1].
#=GF CC   SR-25 is also implicated, along with heat-shock-protein-27, as a
#=GF CC   mediator in the Rac1 (GTPase ras-related C3 botulinum toxin
#=GF CC   substrate 1) signalling pathway [2].
#=GF SQ   90
#=GS F0ZXL9_DICPU/2-64     AC F0ZXL9.1
#=GS B4G424_DROPE/1-138    AC B4G424.1
#=GS F5H7X4_HUMAN/129-307  AC F5H7X4.1
#=GS H3DEH5_TETNG/106-205  AC H3DEH5.1
#=GS G3I4Y5_CRIGR/6-251    AC G3I4Y5.1
#=GS H0Z518_TAEGU/3-232    AC H0Z518.1
#=GS C9QP01_DROME/2-148    AC C9QP01.1
#=GS G3UEC1_LOXAF/6-229    AC G3UEC1.1
#=GS F7AKV2_MACMU/99-320   AC F7AKV2.1
#=GS G5AWS1_HETGA/1-108    AC G5AWS1.1
#=GS Q8TEM4_HUMAN/208-425  AC Q8TEM4.1
#=GS B3S4J7_TRIAD/19-146   AC B3S4J7.1
#=GS G3RPC0_GORGO/206-424  AC G3RPC0.1
#=GS H0W757_CAVPO/67-183   AC H0W757.1
#=GS Q298K4_DROPS/1-138    AC Q298K4.1
#=GS B4MBZ2_DROVI/1-139    AC B4MBZ2.1
#=GS E9G8W6_DAPPU/3-207    AC E9G8W6.1
#=GS D6WEC8_TRICA/86-167   AC D6WEC8.1
#=GS B4PL22_DROYA/1-140    AC B4PL22.1
#=GS E9IA81_SOLIN/258-431  AC E9IA81.1
#=GS D3YWC2_MOUSE/2-199    AC D3YWC2.1
#=GS B3V0L1_HUMAN/6-225    AC B3V0L1.1
#=GS F1NHS0_CHICK/5-231    AC F1NHS0.1
#=GS F6VBC1_HORSE/6-230    AC F6VBC1.1
#=GS B2RE15_HUMAN/6-217    AC B2RE15.1
#=GS F6S524_XENTR/6-225    AC F6S524.1
#=GS E2A8S0_CAMFO/284-445  AC E2A8S0.1
#=GS E9G8W5_DAPPU/3-205    AC E9G8W5.1
#=GS H2TL98_TAKRU/6-245    AC H2TL98.1
#=GS H9J9Y4_BOMMO/1-159    AC H9J9Y4.1
#=GS Q17BR7_AEDAE/45-173   AC Q17BR7.1
#=GS F6Y6B1_CALJA/6-216    AC F6Y6B1.1
#=GS B4JIG9_DROGR/1-153    AC B4JIG9.1
#=GS H9GMK8_ANOCA/57-228   AC H9GMK8.1
#=GS C3YDE1_BRAFL/1-68     AC C3YDE1.1
#=GS D3Z6F1_MOUSE/19-227   AC D3Z6F1.1
#=GS G3WL28_SARHA/36-276   AC G3WL28.1
#=GS G3P006_GASAC/46-242   AC G3P006.1
#=GS I1FF50_AMPQE/1-204    AC I1FF50.1
#=GS AR6P4_HUMAN/129-359   AC Q66PJ3.1
#=GS H2TL99_TAKRU/6-217    AC H2TL99.1
#=GS H2LP30_ORYLA/2-197    AC H2LP30.1
#=GS AR6P4_XENLA/8-245     AC Q3KPW4.2
#=GS B0BMG4_XENTR/6-249    AC B0BMG4.1
#=GS F6YRL7_CIOIN/2-199    AC F6YRL7.2
#=GS B4QSG1_DROSI/1-140    AC B4QSG1.1
#=GS H7BZV4_HUMAN/7-209    AC H7BZV4.1
#=GS B3P797_DROER/1-139    AC B3P797.1
#=GS F5GYV5_HUMAN/6-211    AC F5GYV5.1
#=GS F4PL70_DICFS/70-290   AC F4PL70.1
#=GS AR6P4_CHICK/4-230     AC Q5F4A9.1
#=GS Q4RT29_TETNG/2-257    AC Q4RT29.1
#=GS F4WVX6_ACREC/68-247   AC F4WVX6.1
#=GS B4NBN5_DROWI/1-143    AC B4NBN5.1
#=GS F1Q2D4_CANFA/79-312   AC F1Q2D4.1
#=GS H9KI82_APIME/261-419  AC H9KI82.1
#=GS G1QPN8_NOMLE/127-357  AC G1QPN8.1
#=GS Q55D05_DICDI/9-272    AC Q55D05.1
#=GS G6CUY9_DANPL/1-162    AC G6CUY9.1
#=GS B4HGH6_DROSE/1-140    AC B4HGH6.1
#=GS A7USQ6_ANOGA/27-204   AC A7USQ6.2
#=GS Q9VCD4_DROME/1-140    AC Q9VCD4.2
#=GS AR6P4_RAT/6-230       AC Q4V8I5.1
#=GS B3V0L0_HUMAN/129-340  AC B3V0L0.1
#=GS H3BE34_LATCH/2-243    AC H3BE34.1
#=GS B4K7D5_DROMO/1-147    AC B4K7D5.1
#=GS H0XEC0_OTOGA/58-267   AC H0XEC0.1
#=GS G1MWR1_MELGA/1-183    AC G1MWR1.2
#=GS E2BI88_HARSA/1-125    AC E2BI88.1
#=GS H3IM43_STRPU/533-671  AC H3IM43.1
#=GS G3SW00_LOXAF/6-185    AC G3SW00.1
#=GS H2TL97_TAKRU/6-210    AC H2TL97.1
#=GS Q4V5H0_DROME/2-74     AC Q4V5H0.1
#=GS G1M944_AILME/61-287   AC G1M944.1
#=GS H2Q752_PANTR/129-359  AC H2Q752.1
#=GS F8WEP2_HUMAN/106-169  AC F8WEP2.1
#=GS B3LWY8_DROAN/1-140    AC B3LWY8.1
#=GS F1RFJ6_PIG/6-229      AC F1RFJ6.1
#=GS F8WCT1_HUMAN/6-228    AC F8WCT1.1
#=GS F6XIW1_CALJA/6-235    AC F6XIW1.1
#=GS F1NPS9_CHICK/4-230    AC F1NPS9.1
#=GS F7AKY6_MACMU/102-328  AC F7AKY6.1
#=GS F4NXF9_BATDJ/75-173   AC F4NXF9.1
#=GS F6XHN5_CALJA/6-224    AC F6XHN5.1
#=GS F6TAV8_ORNAN/2-226    AC F6TAV8.1
#=GS B0W116_CULQU/1-209    AC B0W116.1
#=GS F1N671_BOVIN/78-312   AC F1N671.2
#=GS AR6P4_MOUSE/6-228     AC Q9JM93.1
#=GS H2NJ09_PONAB/126-356  AC H2NJ09.1
#=GS AR6P4_DANRE/2-220     AC Q502P0.1
F0ZXL9_DICPU/2-64                ............................................krr------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................------------MGPLSDFEYEKLRSTYTEVYDEDTGRMR..AV.RGDGEIIER...I.VTKEQHKAINY............................IATH--------------hptky.....
B4G424_DROPE/1-138               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....K.EHK.EKHK....S..RKSKKH...TKQKD........ATP--P.......PQ....A.P..PPPPPPD.ISSDE..--DF.A..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRIR..LI.KGDSEVLEE...I.VSKERHTDINK............................KATRGDGEYYESRSLDA-a.........
F5H7X4_HUMAN/129-307             ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.STSQas........................pspCITERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRT-..--.---------...-.-----------............................------------------..........
H3DEH5_TETNG/106-205             ...............................wpissqdpslnapicg------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..---Q.E..IP................VMTDEQKARLSTKRPLTKEEYEARQSVIRKVVDPETGRTR..LI.RGEGEIIEE...I.VSREQHKDINK............................QATRGDGNAFQRKL-GI-n.........
G3I4Y5_CRIGR/6-251               ..............................................s-RKRSRSRSRSR.......gRRGS.EKRSK---....KSSKDASK.NC..S...ASKSP.GHKA.............................CSTSEE..RSKHKA.R-RT............AR.SSSS.SS..S......SSS...S...S.....SA...S......S...S..SSSDGRKKRG..KNK........D.K......-.....K.RKK.KKKR....K..KKLKRK...GKEKA........-VVLHP.......AE....A.L..PGPSLDQ.WHKSA..GE-D.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINKvgvtalamlcprcvytqylmlltcflpqQATRGDGLAFQMRA-GL-l.........
H0Z518_TAEGU/3-232               ......................................hsrsrkrsrSRSKSHSRSRQE........-RKE.KKRRKSSK....DSQQGGSS.PR..A...RG--E.K--R.............................VPGSRK..DKKKRK.ASTSs.........fgTS.SSTS.SS..S......SSS...S...S.....SS...S......S...D..DSNSKKKQVK..QKD........K.K......K.....R.KKK.KKKI....K..KKSKKK...AKERA........KEEKAK.......GE....E.V..PGPSLEQ.WQKES..VVDS.-..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VSKERHKEINK............................QATRGDGLAFQVRT-GM-l.........
C9QP01_DROME/2-148               ..........................................rspas------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......R...I..MGKSEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...NRKKE........-ESPPI.......AS....P.T..PIQPERV.NQE-E..EDDF.A..IP................IALMNSKSH----APETPEEYQRRQSQIRKEVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGEFYEARSLDA-a.........
G3UEC1_LOXAF/6-229               ...............................................SRKRSRSRSRSR........GRGA.EKRRQKRS....KDSPRSCSaSR..S...QGRKA.STAP.............................GAEERS..KHKARR.KPRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRR..KHK........D.K......-.....K.RKK.KKRR....K..KKLKKK...NKEKA........--KVQQ.......AE....A.L..PGPSLDQ.WHRAA..AEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
F7AKV2_MACMU/99-320              ..............................repgrgssgklhlcsgk------------........----.PRRRRSPC....RCRGRRFT.SS..P...PGLLA.SPSP.............................CITERS..KHKARR.RPRS............SS.SSSSsSS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.KRR.RKKK....K..KKLKKK...GKEKV........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
G5AWS1_HETGA/1-108               .............................................me------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........---VQQ.......AE....A.L..PGPSLDQ.WHRSA..GEED.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
Q8TEM4_HUMAN/208-425             ................................rgssgklhlcsgkpl------------........----.--RKRSPC....SRSVPAPG.QS..R...GRRFT.SSPPglpa.....................spspCITERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................------------------vgvaplpa..
B3S4J7_TRIAD/19-146              ......................................clnknkrkh------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...S..SEDSHEKKKH..SKK........K.S......K.....K.NKK.DKKS....A..KKEKRK...DKKYK........-NSQDA.......D-....-.-..-DAAAKT.SQKDA..S---.T..GP................V---EQQK---NFAPMTKEEWDKQQSVIRRVYDPETGRNR..LI.KGSGEILEE...I.VSKEQHQRINK............................------------------vcla......
G3RPC0_GORGO/206-424             ......grgssgklhlcsgkplrkrspcrrsvpapgqsrgrrftsyp------------........----.--------....--------.--..-...-----.---Pglpa.....................spspCITERS..KQKARR.RPRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................------------------vgvaplpa..
H0W757_CAVPO/67-183              ...........................................sdgr------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..---KKR...GKHKA........--GVQP.......AE....A.L..PGPSLEQ.WHQSA..WEED.N..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..W-.-GALGTTRP...I.ACHERHREINK............................QATRGDGLSFQIRA-GL-l.........
Q298K4_DROPS/1-138               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....K.EHK.EKHK....S..RKSKKH...TKQKD........ATP--P.......PQ....A.P..PPPPPPD.ISSDE..--DF.A..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRIR..LI.KGDSEVLEE...I.VSKERHTDINK............................KATRGDGEYYESRSLDA-a.........
B4MBZ2_DROVI/1-139               ...........................................mgks------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..--DKKSKKKH..KSK........R.K......E.....H.KEK.HKDK....A..KKSKRQ...EKK--........----DT.......PP....P.K..IETPLVAaADSGS..EEDF.A..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRTR..LI.KGDSEILEE...I.VSKQRHCDINR............................KATSGDGDYFEAQS----faaa......
E9G8W6_DAPPU/3-207               ......................................qiitngsrs------------........----.-VSKKSVL....ESKQKRKK.EK..K...SKKSL.KEKI.............................SRKKHS..KKKSRK.R-HS............SS.SSDS.SS..S......SSS...S...S.....SS...L......K...S..SEDEKAKKRK..KKN........K.K......S.....K.---.AKKQ....K..AKLEAN...NVK--........---AVI.......TE....I.Q..LTLPVSV.SQTKP..TLET.N..VG................PHIDLNSSKMRA--PMTKEEYEKQQNTLKWIVDPETGRRR..LI.RGSGEIMEE...I.VSRERHQAINK............................QATVADGNFFQAQA----nlk.......
D6WEC8_TRICA/86-167              ........................................sdipvel------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................------MAKSKAMAPMTKEQWEKQQSVVRRVYDETTGRHR..LI.KGDGEVIEE...I.VSRDRHKAINQ............................QATRGDGEFFQAQM----fnrl......
B4PL22_DROYA/1-140               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...SRKKE........-ESPPI.......SS....P.T..PIQPERG.NQEE-..EEDF.A..IP................IALMNSKSH----APETPEEYQRRQSQIRREVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHMEINK............................KATRGDGEFYEARSLDA-a.........
E9IA81_SOLIN/258-431             ....................................sscssssshvs------------........----.--------....--------.--..-...-----.----.............................------..------.----............SS.SSSS.SS..SdtdsssSSS...S...I.....DS...S......E...N..ERKQKKAKKK..AKK........L.K......-.....K.AMK.KRKK....K..KRMKKK...LKKKL........KKSATK.......KK....GhG..KKKSKEN.KQVQD..GKEK.A..KE................IVLDV-TERAKVMAPMTKEEWEKRQSIVRRIYDEETGRHR..LI.KGDGEVLEE...I.VSRERHKDINR............................QATKGDGKYFQ-------..........
D3YWC2_MOUSE/2-199               ...........................................ahvg------------........----.--------....----SRKR.SR..S...RSRSR.SGRR.............................GSEKRK..RSKHKA.Q-RT............SR.SSST.SS..S......SSS...S...S.....SA...S......S...S..SSSDGRKKRA..KHK........E.K......K.....R.KKK.KKKR....K..KKLKKR...VKEKA........-VAVHQ.......AE....A.L..PGPSLDQ.WHRSA..GEDN.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRT-GL-l.........
B3V0L1_HUMAN/6-225               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.STSQas........................pspCITERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
F1NHS0_CHICK/5-231               .............................................grSRKRSRSSSRSP........--SG.SGREKGGA....RRSAASPG.PR..H...RLSSA.AARE.............................GRKKEG..RKKKKR.KGKAsss.....drssSS.RSSS.SS..S......STS...S...S.....DS...D......T...R..AKQHSRRKRG..KHK........D.K......-.....-.-KK.KKKM....K..KKLKKK...SKERV........KEERGV.......SE....A.L..PGPSLEL.WQKEP..LA-E.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VSKERHKEINK............................QATRGDGLAFQVRT-GM-l.........
F6VBC1_HORSE/6-230               ..............................................s-RKGSRSRSGTR........ERGS.EKRRKKSS....KDAPR-SC.SA..S...RSQGR.KASTvs........................pgaEAQRRS..KHKARR.RPRS............SS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KHK........D.K......-.....K.RKK.KKKR....K..KRLKKK...GKEKA........--KVQQ.......AE....A.L..PGPSLDQ.WHRAA..EEEE.H..GP................VLTDEQKTRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQLRA-GL-l.........
B2RE15_HUMAN/6-217               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.ST--.............................-SQERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..PI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
F6S524_XENTR/6-225               .............................................lk--KRSRSRSPKVs......qSKSS.KKKKKLSSr..cRSSSDSPV.RK..H...STLAK.---Yra........................evpDRRKKE..RRKKKR.RRTV............ST.TSSS.SS..S......SES...S...S.....SS...S......S...S..CSSSDDSVDS..SCK........S.K......-.....-.--K.SSHT....S..FKLECQ...DAK--........---GTA.......KE....V.L..PGPSINP.CQKES..PE-D.T..GP................ALTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRMR..LI.KGDGEVLEE...I.VSKERHKEINK............................QSTQKDGLAFQMHS-GM-f.........
E2A8S0_CAMFO/284-445             ..........................................gditg------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.--SS.SS..S......STD...S...S.....ED...E......R...K..QKKAKKKAKK..LKK........A.-......M.....K.KRK.KKRM....K..KKLKKK...LKKST........SKKKGH.......SK....K.K..SKENKEI.QGSGK..RE-S.-..TK................EVVPEVMEKAKAMAPMTKEEWEKRQNMIRRIYDQETGRYR..LI.KGDGEVLEE...I.VSRDRHKEINK............................QATKGDGEYFQAHL----kmk.......
E9G8W5_DAPPU/3-205               ......................................qitagkslv------------........----.--------....SKSDVERK.LK..SkkgKKSKK.SSKE.............................KPRKSH..SKKKSR.K-RH............AS.SSSD.SS..D......SSS...S...S.....SS...S......E...S..SENEKAKKRK..KKS........K.K......S.....K.AKK.QKAK....L..EATKA-...--KAV........IE--KL.......PV....I.V..PVQVVKL.SIPEA..DV--.-..GP................HI-DLKSSKIRA--PMTKEEYEKQQSTLKWITDPETGTKR..LI.RGSGEIVEE...M.ASKERPHSVKPt.........................psTLFAADGNFFQPQ-----tnmk......
H2TL98_TAKRU/6-245               ...............................................NRSSSHDRSIRE........NKTEpKKRRRSSS....SSSSSS--.SS..S...RSRSK.SSKK............................sSHKNKD..VKTKKK.RRRS............SS.SSST.SS..S......SSS...S...S.....SS...N......E...K..TKRKKSKKSK..AKK........K.K......A.....K.LKK.QNKK....E..KKKKQK...LKKKT........KAAAAA.......AA....A.A..AAAAVAV.LPSLP..SPAA.V..KPpsypelwqsdevelgpVMTDEQKARLSTKRPLTKEEYEARQSVIRRVVDPETGRTR..LI.RGEGEIIEE...I.VSREQHKDINK............................QATKGDGNTFQKKL-GI-n.........
H9J9Y4_BOMMO/1-159               .............................................mg------------........----.--------....--------.--..-...-----.----.............................------..KEKSRK.KKRS............SS.ESSS.SS..S......SSD...S...S.....RE...K......K...R..IRKLKKKLRKeqKKT........E.K......I.....I.KKK.LKKE....K..KRLKKE...YLKRS........QSRDKS.......PE....V.S..ADIPVEL.MEIS-..----.-..--................----------KAMAPMTKEEWEKKQSIIRRVLDEETGRYR..LI.KGDGEVLEE...I.VSKERHKEINR............................QATQADGALFQAQTL---h.........
Q17BR7_AEDAE/45-173              .............................................kr------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...E..RKEAKAKRRA..LKK........Q.E......R.....E.QRK.AEKR....L..RKQQKK...EQGRS........-EPAAI.......AG....A.D..CGVPLDL.MNTQA..RA--.-..--................--------------PETREQYEARQAVVRRVVDPETGRTR..LV.KGDGEILEE...C.VSRDRHLEINR............................QATAGDGAEFQRKTIGWK..........
F6Y6B1_CALJA/6-216               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.S---.............................-ESQER..SKHKAR.RPRS............SS.SSSS.GS..S......SSS...S...S.....SS...S......S...S..SSSGGRKKRG..KHR........D.K......R.....R.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
B4JIG9_DROGR/1-153               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....-S...D......K...K..AKKKHKSERK..QHK........E.K......N.....K.DKV.KKSR....K..HEKAKK...PKE-Sp......sAANNEM.......AP....A.IppPNPPGQT.ATADSgsEEDF.A..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRTR..II.KGDSEILEE...I.VSKQRHGDINR............................KATSGDGEYFEAQS----fan.......
H9GMK8_ANOCA/57-228              ...........................................stsh------------........----.--------....--------.--..-...-----.----.............................------..------.----............SS.GSSS.DS..S......DSSpeeS...S.....DG...E......S...R..PKRKKPSKKK..LAK........G.K......D.....K.KEK.KRKR....K..RKAKKK...AKKKMk......eKEGKTR.......LE....E.L..PGPSLDQ.WQRET..VAD-.P..GP................ALTDEQKSRIQAMKPMTKEEWDARQSVIRRVTDPETGRTR..LI.KGDGEVLEE...I.VTKERHKEINK............................QASRGDGLTFQMRT-GM-l.........
C3YDE1_BRAFL/1-68                ...............................................------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................------------MRPMTKEEWDKQQSVVRRVFDPDTGRNR..LV.KGDGEIIEE...I.VSKERHKQINQ............................QATQGDGLSFMR------glgln.....
D3Z6F1_MOUSE/19-227              ................tsrtqkkvpdvllesplggslpleqgtkalp------------........----.--------....--------.--..-...-----.--SP.............................CITERS..KHKAQR.TSRS............SS.TSSS.SS..S......SSS...A...-.....--...S......S...S..SSSDGRKKRA..KHK........E.K......K.....R.KKK.KKKR....K..KKLKKR...VKEKA........-VAVHQ.......AE....A.L..PGPSLDQ.WHRSA..GEDN.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRT-GL-l.........
G3WL28_SARHA/36-276              ............................................shk-RSRSRSRSGSHg.....ppEHGE.RRRRRRSS....KDMGRSPS.AS..G...S----.---Qgqris...................lgsngEERSRD..KARKRR.RPRS............SS.SSSS.SS..S......SSS...S...SsstssSS...S......S...G..ASSGGRKKRG..KRK........D.K......K.....StKKK.AKKK....L..RKKKKK...KKKKEek....aaKAKAKA.......VE....E.M..PGPSLDQ.WRKEP..PV-E.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHKEINK............................QATRGDGLTFQLRA-GL-l.........
G3P006_GASAC/46-242              ...........................................kktp------------........----.--------....--------.--..-...-----.----.............................-NKSQD..VKTQRKkRRRS............SS.SSSS.TS..S......SSS...S...S.....TS...D......E...KtkKKKSKAKKKK..LKK........M.K......A.....K.LKK.QKKKekreK..KKKEKL...KKKEE........KKKAEVvllppspPV....E.K..PPSYLEV.WQSDE..GAVE.L..GP................VMTDEQKARLATKRPITKEEYEARQSVIRRVVCPETGRTR..LV.RGEGEIIEE...I.VSREKHKDINK............................QATKGDGKEFQRKL-GV-n.........
I1FF50_AMPQE/1-204               ............................................mss------------........----.--------....--------.--..-...-SSSL.SSSE.............................SEGERR..EKRRKR.KRKI............EK.DSSL.SE..E......SSS...S...D.....GG...Q......R...V..ILKKKKRKKE..KGK........D.D......SsftsfQ.AKK.KKKH....S..KSSKRH...NKEKH........KKSKKK.......KS....K.D..NKSNLDW.SNAIQ..LS--.A..PPvpsapp...ppidttpLITTHPPLK-RSYGPMTQFDYVKQQSVVRRVVDPETGRSR..LV.KGDGEIIEE...I.VSRDRHKAINK............................LATQGDGLSFQT------glk.......
AR6P4_HUMAN/129-359              ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.STSQgrkastap.............gaeaspspCITERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
H2TL99_TAKRU/6-217               ...............................................NRSSSHDRSIRE........NKTEpKKRRRSSS....SSSSSSSS.SR..S...-----.----.............................----RN..VKTKKK.RRRS............SS.SSST.SS..S......SSS...S...S.....SS...N......E...K..TKRKKSKKSK..AKK........K.K......A.....K.LKK.QNKK....E..KKKKQK...LKKKTk......aAAAAAA.......AA....A.A..AAVAVEL.WQSDE..V--E.L..GP................VMTDEQKARLSTKRPLTKEEYEARQSVIRRVVDPETGRTR..LI.RGEGEIIEE...I.VSREQHKDINK............................QATKGDGNTFQKKL-GI-n.........
H2LP30_ORYLA/2-197               ..............................................g-RSRSPSKDVRE........KKQM.KKKRRKSS....SSSSSTSS.SS..S...RSRSR.SSKKk...........................tHKKKQDlnTKRKKR.RTRS............SS.SSST.SS..S......SSS...T...S.....SS...SsssderS...R..KKKMKAKKKK..LMK........K.K......A.....E.LKK.QKKM....E..KKQKKI...KKREKkmkkelevG-TVQI......pAE....N.Q..PPSYLEV.WQNDE..EAVE.L..GP................VMTDEQKARLSTKRPLTKEEYEARQSVIRRVVDP------..--.---------...-.-----------............................------------------..........
AR6P4_XENLA/8-245                .............................................ik-RSRSRSPKVSQ........SKSS.KKKKRSSS....RCRSGSDS.PA..R...KH-ST.LAKYrae.......................vpdRRKKER..RKKRRK.RTVSt..........tSS.SSSE.SS..S......SSS...S...S.....SS...D......D...S..GDSTCKSKRS..SHR........K.K.....kN.....K.KQI.KRKK....A..KKNKKL...KKKTSfkl..ecqDTKSTE.......KE....V.L..PGPSVNP.CKKES..P-EV.S..GP................ALTDEQKSRIQAMKPMTKEEWDAQQSVIRKVVDPETGRIR..LI.KGDGEVLEE...I.VSKDRHKEINK............................HATQKDGLEFQMHS-GM-f.........
B0BMG4_XENTR/6-249               .............................................lk--KRSRSRSPKVs......qSKSS.KKKKKLSSr..cRSSSDSPV.RK..H...STLAK.---Yrae.......................vpdRRKKER..RKKKRR.RTVStts.....ssssS-.SESS.SS..S......SSS...C...S.....SS...D......D...S.vDSSCKSKKSS..HRK........K.K......Tkk.qmK.KKK.AKKK....S..KKLKKK...T---Sfkl..ecqDAKGTA.......KE....V.L..PGPSINP.CQKES..PE-D.T..GP................ALTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRMR..LI.KGDGEVLEE...I.VSKERHKEINK............................QSTQKDGLAFQMHS-GM-f.........
F6YRL7_CIOIN/2-199               ...........................................gskk------------........----.--EKKDVR....EVVHKVKK.AK..H...EKKSE.DSNK............................rSYFSST..SKKRKK.R-Y-............--.----.-S..S......SSC...S...T.....DS...E......R...K..VKKKKRKRTT..SEDtsssedrtQ.K......T.....L.KRK.KAKH....K..KKTKKK...KMKKE........KTIKTT.......DE....N.S..PK-NIKS.LKKNK..E---.-..--................-ETADPDPRALAMRPMTQEEWEKRQSVMRHVYDAETGRTR..LV.KGDGEIMEE...I.VSRERHLAINK............................QATIGDGNSFQAK-----..........
B4QSG1_DROSI/1-140               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...SRKKE........-ESPPI.......AS....P.S..PIQPERV.NQ-EE..EDDF.A..IP................IALMNSKSH----APETPEEYQRRQSQIRKEVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGEFYEARSLN--aa........
H7BZV4_HUMAN/7-209               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.ST--.............................-SQERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................------------------vgvaplpa..
B3P797_DROER/1-139               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...SRKKE........-ESPPI.......GS....P.T..PIQPERG.NQE--..EEDF.A..IP................IALMNSKS----HAPETPEEYQRRQSQMRREVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGDFYEARSLDA-a.........
F5GYV5_HUMAN/6-211               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.STSQgrka.....................stapGAEERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................------------------..........
F4PL70_DICFS/70-290              ............................................srd-RSRARSKSRDR........SDRD.RYRQRSRS....RSRDKSTS.NNvdK...RERDD.DKEN............................rVKKRKS..RSKSRS.RSRS...........rSI.SSSS.SS..S......YDS...S...S.....DS...S......S...S..SSEERRRKRK..KKK........R.K......-.....-.EKK.EKKQ....R..KKEKKE...KKKLK........-EQQEL.......EElekkK.Q..LERQMAM.ERQQQ..KQQQ.Q..QE................LETNTPPKR--VMGPISNESYDKLRNTFVEKYDEDTGRMR..VY.RATGELIER...V.VSKEKHKEINY............................IATH--------------hptky.....
AR6P4_CHICK/4-230                .............................................grSRKRSRSSSRSP........--SG.SGREKGGA....RSSAASPG.PR..H...RLSSA.AARE.............................GRKKEG..RKKKKR.KAKAsss.....drssSS.RSSS.SS..S......STS...S...S.....DS...D......T...R..AKQHSRRKRG..KHK........D.K......-.....-.-KK.KKKM....K..KKLKKK...SKERV........KEERGV.......SE....A.L..PGPSLEL.WQKEP..LADS.-..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VSKERHKEINK............................QATRGDGLAFQVRT-GM-l.........
Q4RT29_TETNG/2-257               ...............................................NRSRSHDRSLREk......kTKEQ.RKRRRSSS....SSSSSSSS.SS..S...RSRSK.SSKN............................sSHKNRD..VKTKKK.RRRS............SS.SSSS.SS..S......STS...S...S.....SS...S......S...S..PSDEKRKKKK..SKS........K.K......S.....K.AQK.EKGE....A..EEAEQE...GEKEEt......eAEERRV.......KR....A.A..AEGRCRL.PPPAA..GLQA.A..NPprvfpe...llaradeVMTDEQKARLSTKRPLTKEEYEARQSVIRKVVDPETGRTR..LI.RGEGEIIEE...I.VSREQHKDINKelavca...............qtkaaftQHHARAAGLGRARAVGVL..........
F4WVX6_ACREC/68-247              .....................................dsscsssssn------------........----.--------....--------.--..-...-----.----.............................------..------.---S............SS.SSSS.SS..S......DTN...S...S.....NS...G......SsidS..SEDEKKQKKA..RKK........A.KkfkkalK.....K.RKK.KKRM....K..KKLKKK...FKKSV........SKKKGH.......NK....K.K..SKGNKEV.QDRKE..KMKE.-..--................-IVSNVIERGKAMAPMTKEEWEKRQSIVRRVYDEETGRHR..LI.KGDGEVLEE...I.VSRERHKEINK............................QATKGDGKYFQTH-----lkmn......
B4NBN5_DROWI/1-143               ............................................mgs------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..-----DKKKK..KHK........H.K......R.....K.EHK.EKHK....T..RKSKKH...EKHRRe......rSKDNET.......SV....S.Q..PAATANP.PQAES..GDEDfA..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRIR..LI.KGDSEILEE...I.VSKDRHTEINK............................KATRSDGEYYEAHSLG--sa........
F1Q2D4_CANFA/79-312              ...............................................SRKRSKSRSRSR........GRGS.EKRRKKSS....KDAPRS--.-C..S...ASRCQ.DRKA.............................IITSSG..AEGEDR.REWEggvgtlrrplqaAE.RASR.GG..G......SQR...SaerS.....TW...T......S...G..LKDTQIPEAG..PAH........D.V......R.....-.KRS.KHKA....R..RRPRSK...GKEKA........-KLQQQ.......GE....A.L..PGPSLDQ.WHRSA..EEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..WA.VGRSSAPHT...L.NAQERHREINK............................QATRGDGLAFQMRA-GL-l.........
H9KI82_APIME/261-419             .............................................ss------------........----.--------....--------.--..-...-----.----.............................------..------.----............-S.SSSS.SS..S......TSS...S...C.....SS...S......S...S..DTSEDEKKRK..KAR........R.K......-.....-.AKK.LKKA....M..KKRRKK...KRMKK........----KL.......KK....K.L..KKSKKKL.RNTDK..SKES.I..SK................DVSQEISEKSKAMAPMTKEEWEKKQNVIRKVYDEETGRYR..LI.KGDGEVIEE...I.VSRERHKEINK............................QATKGDGEYFQARL----kan.......
G1QPN8_NOMLE/127-357             ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DA..S...RNCSA.STSQgrkastas.............gaeaspspCITERS..KQKARR.RPRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYR........T.R......R.....G.GR-.-RRK....R..KKLKKK...GKEKA........--EAQQ.......ME....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
Q55D05_DICDI/9-272               yrdrsdsrsreryenrhklyrdrsrsrsrsidkeryhesdrhrlyrd-RSKSRERDRIN........TKHD.K-------....--------.--..-...-----.---NnleidkkrnterdenkyrdrdknrgrsrsRSKSRE..RYKKYK.RNRS............RS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SNERKKRKKK..KKE........E.K......R.....K.RKK.EKKE....K..KEEKEL...KKKLK........KDS-KK.......SS....S.T..VSTTTTT.TTTAA..AASA.T..NTs.............nlVNNNNNK---KKMGPISDEDYEKLKNSYREVFDEDSGRTR..VV.NGNGEIVER...I.VSREQHKAINY............................IATH--------------hptqf.....
G6CUY9_DANPL/1-162               .............................................mg------------........----.--------....--------.--..-...-----.----.............................------..KEKAKK.RRH-............-S.TSES.SS..S......SSS...S...D.....SS...R......E...K..KKLRKLKKKL..KKE........Q.K......K.....T.EKL.LKKK....L..KEEKKK...LKRKQ........SEERSQ.......NQ....E.K..TKDE---.-----..-ASS.D..IP................L---ELMEKSKAMAPMTKEEWEKRQSVIRRVQDEETGRYR..LI.KGDGEVIEE...I.VSRDRHKEINR............................QATMADGNFFQLQT----gqk.......
B4HGH6_DROSE/1-140               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...SRKKE........-ESPPI.......AS....P.S..PIQPERV.NQ-EE..EDDF.A..IP................IALMNSKSH----APETPEEYQRRQSQIRKEVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGEFYETRSLN--aa........
A7USQ6_ANOGA/27-204              ...........................................asst------------........----.--------....--------.--..-...-----.----.............................------..------.----............-S.GTSD.SD..S......SST...S...S.....SS...R......S...S..SVERKRRKKE..LKK........KlA......K.....Q.QKK.EAKA....K..KKALRK...EKKAR........RKQEKL.......ES....K.L..AKRKLKE.ERKSR..RKQE.K..HSkdgdi.....pnsncgIPLDL--MNRKAMAPETREEYEARQSILRRVVDPETGRTR..LI.KGDGEIIEE...C.VSRDRHKEINR............................QATAGDGAEFQRKTLG--rn........
Q9VCD4_DROME/1-140               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SEKKSKK..KHK........E.K......R.....R.EHK.EKHK....S..KKSKKH...NRKKE........-ESPPI.......AS....P.T..PIQPERV.NQ-EE..EDDF.A..IP................IALMNSKSH----APETPEEYQRRQSQIRKEVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGEFYEARSLDA-a.........
AR6P4_RAT/6-230                  ..............................................s-RKRSRSRSRSR.......gRRGS.EKRSKRSS....KDSSRNCS.TS..K...SQGHKaSSTS.............................GVEERS..KHKAQR.TSRS............SS.SSSS.SS..S......SSS...S...S.....ST...S......S...S..SSSDGRKKRG..KHK........D.K......K.....K.RKK.KKKR....K..KKMKRK...GKEKA........-VVVHQ.......AE....A.L..PGPSLDQ.WHRSA..GEDN.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
B3V0L0_HUMAN/129-340             ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.ST--.............................-SQERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
H3BE34_LATCH/2-243               ..............................................g-RSRSRERSRSRtktsscgkGLKR.DGKKRSRS....SSSSRRST.SL..S...KKCHH.STSP.............................SKERKP..EKKKAK.RKPSa.........stSS.DSSS.PA..S......STS...T...C.....SSslsD......S..dT..ESKESKQQKG..KNK........T.K......K.....S.KKK.SKKM....N..RKSKKM...KKKKAke....apTAAKPK.......LS....K.M..AGPSVEQ.WQRET..WV-E.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETRRTR..LV.KGDGEILEE...I.VSRERHKEINR............................QATVGDGVSFQTRM-G--ln........
B4K7D5_DROMO/1-147               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..-SEKKSKKRH..KSK........R.K......E.....Q.KEK.HKIK....S..RKSKREdkiKLKQA........KEETPV.......VD....E.I..SLQVAAA.ADSGG..EDDF.A..IP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRTR..LI.KGDSEILEE...I.VSKERHCDINK............................KATSSDGAYFESQS----faaa......
H0XEC0_OTOGA/58-267              ...............................................SRKRSRSRSRSR........GRGS.EKRRK---....----NSSR.DA..S...RSCSA.S---.............................GSQERS..KHKARR.RPRS............SS.SSSS.SS..S......SSS...S...S.....SS...S......S...P..SSSDGRKKHG..KHK........D.K......-.....-.KRK.KKKK....K..KKLKKK...GKEKT........--EAQQ.......AE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LM.VEAGKAEPT...L.VSSSRHREINK............................QATRGDGLAFQMRA-GL-l.........
G1MWR1_MELGA/1-183               ..............................................g------------........----.--------....--------.--..-...-----.----.............................-RKKEG..RKKKKR.KANAsss.....dsssSS.RSSS.SS..S......STS...S...S.....DS...D......T...R..AKRHGRRKRG..KHK........D.K......-.....-.-KK.KKKT....K..KKLKKK...SKERV........KEDRGV.......GE....A.L..PGPSLEL.WQKEP..QADP.-..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VSKERHKEINK............................QATRGDGLAFQVRT-GM-l.........
E2BI88_HARSA/1-125               .............................................mq------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......K.....R.KKK.KKRM....R..KKLKKK...SKKIV........PKKKRH.......SK....K.K..PKEKTG-.--KED..T---.-..TN................EIASEMAEKAKAMAPMTKEEWEKRQSIVRKVYDKETGRYR..LI.KGDGEVLEE...I.VSRDHHREINR............................QATKGDGEYFQARL----kmn.......
H3IM43_STRPU/533-671             .............................................kh------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..-KKEHRKEKK..QKD........I.L......R.....K.KSK.EKKK....KatRKQEE-...GSKKK........KTDEVV.......PL....S.G..IQKKLIE.MAKAG..--KK.E..EP................---SEEGSSKRSMVPMTKEQYDKEESKVRRVYDADTGRNR..LI.RGSGEVLEE...I.VSRDRHKEINK............................AATKHDGIAYSK------si........
G3SW00_LOXAF/6-185               ..............................................s------------........----.--------....--------.--..-...RKRSR.SRS-.............................--RSRG..RGAEKR.RQKR............-S.KDSP.RS..C......SAS...R...S.....QG...R......K...A..STAPGAEERS..KHK........A.R......R.....K.PRS.SDGR....K..KRRKHK...AKVQ-........-----Q.......AE....A.L..PGPSLDQ.WHRAA..AEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
H2TL97_TAKRU/6-210               ...............................................NRSSSHDRSIRE........NKTEpKKRRRSSS....SSSSSSSS.SR..S...-----.----.............................----RN..VKTKKK.RRRS............SS.SSST.SS..S......SSS...S...S.....SS...N......E...K..TKRKKSKKSK..AKK........K.K......A.....K.LKK.QNKK....E..KKKKQK...LKKKTk......aAAAAAA.......AA....A.A..AAVAVEL.WQSDE..V--E.L..GP................VMTDEQKARLSTKRPLTKEEYEARQSVIRRVVDPETGRTR..LI.RGEGEIIEE...I.VSREQHKDINK............................------------------llimfvgplh
Q4V5H0_DROME/2-74                ............................................nsk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................-----------SHAPETPEEYQRRQSQIRKEVDPVTGRVR..LI.KGDSEVLEE...I.VTKERHLEINK............................KATRGDGEFYEARSLDA-a.........
G1M944_AILME/61-287              .............................................la----SKSRSRSR........GRGS.EKRRKKSSkdapRSCSASRS.QD..H...KAGN-.---Tssgae...................aspspCITERS..KHKAQR.RPRS............SSpSSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSGGRKKRG..KHK........D.K......R.....R.RRR.KKKR....K..KQLKKK...TKEKA........--KLQQ.......GE....A.L..PGPSLDQ.WHRSA..EEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..W-.----GVLAK...LsPTCSRHREINK............................QATRGDGLAFQMRA-GL-l.........
H2Q752_PANTR/129-359             ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DA..S...RNCSA.STSQgrkastap.............gaeaspspCITERS..KQKARR.RPRS............SS.SSSS.SSspS......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...SKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
F8WEP2_HUMAN/106-169             ..............................................g------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................-----------------KEKAEAQQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
B3LWY8_DROAN/1-140               ............................................mgk------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..---SDKKSKK..SHK........H.K......R.....R.EHK.EKHK....S..KKSKKH...SRQKQ........----GA.......SP....A.I..TEPNIQK.LEQEQ..EQEE.DfsIP................IALMNSKS----HAPETPEEYQRRQSQIRREVDPVTGRTR..LI.KGDSEVLEE...I.VSKERHTEINK............................KATRGDGEYYEQRTLDA-a.........
F1RFJ6_PIG/6-229                 ...............................................SRKRSRSRSRSR........GRGS.EKKRKKSS....KDAPRS-C.SA..S...RSQSR.KASTt..........................ssGAEERS..KHKARR.RPRS............SS.SSSSsSS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KHK........D.K......-.....K.RKK.KKKR....K..KKLKKR...SKEKA........--KVQQ.......AE....A.L..PGPSLDQ.WHRAA..EEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..VG.RGLAPATQG...V.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
F8WCT1_HUMAN/6-228               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.STSQgrka.....................stapGAEERS..KQKARR.RTRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDCLAFQMRA-GL-l.........
F6XIW1_CALJA/6-235               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.SESQgckg.....................saalG-----..--AEGE.DHRHcwa.....grpgSR.EGTP.LG..S......SIS...A...L.....ESpagG......A...H..PVDGLTQARA..GDE........E.R......S.....K.HKA.RRPR....S..SGRKKR...GKHRA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..RSgAGAGLLLLEksqV.LAKRHHREINK............................QATRGDGLAFQMRA-GL-l.........
F1NPS9_CHICK/4-230               .............................................grSRKRSRSSSRSP........--SG.SGREKGGA....RRSAASPG.PR..H...RLSSA.AARE.............................GRKKEG..RKKKKR.KGKAsss.....drssSS.RSSS.SS..S......STS...S...S.....DS...D......T...R..AKQHSRRKRG..KHK........D.K......-.....-.-KK.KKKM....K..KKLKKK...SKERV........KEERGV.......SE....A.L..PGPSLEL.WQKEP..LA-E.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTR..LI.KGDGEVLEE...I.VSKERHKEINK............................QATRGDGLAFQVRT-GM-l.........
F7AKY6_MACMU/102-328             ..................................grgssgklhlcsg------------........---K.PRRRRSPC....RWSVPAPG.QS..R...GRRFT.SSPPglla.....................spspCITERS..KHKARR.RPRS............SS.SSSSsSS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.KRR.RKKK....K..KKLKKK...GKEKV........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
F4NXF9_BATDJ/75-173              ........................vcspkpsptqpiqtlastssqsl------------........----.--------....--------.--..-...-----.----.............................------..------.----............--.----.--..-......---...-...-.....--...-......-...-..----------..---........-.-......-.....-.---.----....-..------...-----........------.......--....-.-..-------.-----..----.-..--................--NKTRVTKRSAMMPMSQKEYLAEQSTIRKVYDQETGRTR..TI.RGSGEVIEE...I.VSRSQQKAINT............................ASTASDGAVFM-------hglt......
F6XHN5_CALJA/6-224               ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DT..S...RNCSA.SESQas........................pspCITERS..KHKAR-.RPRS............SS.SSSS.GS..S......SSS...S...S.....SS...S......S...S..SSSGGRKKRG..KHR........D.K......R.....R.RRK.KKKK....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
F6TAV8_ORNAN/2-226               ..............................................s-RRRSRSRSGSR........GRPE.RSKEMRRK....RGSKERRR.SR..S...ASGSR.SRRP.............................RERSKD..RGRKRR.RPSS...........sSS.STSS.SS..S......SSS...S...S.....SS...S......S...R..SSSGGRKKRS..KRK........D.K......K.....R.RKKkKKKA....K..KKVKKK...CREKG........EAGTQS.......PQ....G.M..PGPSLDQ.WQKEP..LE-E.S..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVVRKVVDPETGRTR..LI.KGDGEILEE...I.VTKERHKEINK............................QATRGDGLAFQLRA-GL-l.........
B0W116_CULQU/1-209               ........................................mkvkrsh------------........----.--------....--------.--..-...----S.SGRS.............................RRSRRD..SSSSST.SSRS............SS.SGSS.RS..S......SSS...S...S.....SS...S......G...S..SPDRKRSKKA..SK-........D.E......S.....S.KKE.QQRK....L..KKLQKK...EAKRErkl..akaQRKALK.......KQ....Q.K..EERKAEK.RRRKE..LKRQ.K..RPtdatcs...sttvdcgVPLDLMNT--RARAPETREEYEARQAIVRRVLDPETGRSR..LV.KGDGEIIEE...C.VSRERHMDINR............................QATAGDGAEFQRKSVGW-n.........
F1N671_BOVIN/78-312              ...............................................SRKRSRSRSRSR........GRGS.EKKRKKSSkdvrRSCSASRS.QS..R...KASST.---Ssgae....................aspspCITERS..KHKARR.RPRS............SS.SSSSsSS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KHK........D.K......K.....R.KKK.KKKR....K..KKLKKR...GKEKA........--RMQQ.......TE....A.L..PGPSLDQ.WHRAA..KEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRplLP.IGWSRQLQG...L.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
AR6P4_MOUSE/6-228                ..............................................s-RKRSRSRSRSRs......gRRGS.EKRSKR--....-----SSK.DA..S...RNCSA.SRSQghka.....................gsasGVEERS..KHKAQR.---T............SR.SSST.SS..S......SSS...S...S.....SA...S......S...S..SSSDGRKKRA..KHK........E.K......K.....R.KKK.KKKR....K..KKLKKR...VKEKA........-VAVHQ.......AE....A.L..PGPSLDQ.WHRSA..GEDN.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRT-GL-l.........
H2NJ09_PONAB/126-356             ...............................................SRKRSRSRSRSR........GRGS.EKRKK---....----KSRK.DA..S...RNCSA.STSQgrkastap.............gveaspspCITERS..KQKARR.RPRSs..........sSS.SSSS.SS..S......SSS...S...S.....SS...S......S...S..SSSDGRKKRG..KYK........D.K......-.....-.KRK.KKKR....R..KKLKKK...GKEKA........--EAQQ.......VE....A.L..PGPSLDQ.WHRSA..GEEE.D..GP................VLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTR..LI.KGDGEVLEE...I.VTKERHREINK............................QATRGDGLAFQMRA-GL-l.........
AR6P4_DANRE/2-220                ..............................................g-GSDSDSRSRSR........-NRE.ENKSRSLS....SSSARRPS.PN..H...EKKHE.H---.............................---SSE..KKKMKR.R---............-R.SSSS.SS..S......SSS...P...S.....PS...R......E...K..KAKKKKKRRE..AKK........L.K......R.....E.KKK.EKKE....K..KRQKKL...ALKAEraa.altaSVPAPV.......PE....E.K..PQTYLKT.WQSEE..T-KE.H..GP................AMTDEQKAKLSTRRPLTKEEYEARQSVIRRVLDPETGRTR..LI.RGDGEILEE...I.VSKERHKDINK............................QSTRGDGDAFQKRL-GI-s.........
#=GC seq_cons                    ..............................................t.................................................................................................pt...tptpp.p..t............up.sSSo.SS..S......SoS...S...S.....sS...s......p...p..spppt+KK+t..KcK........c.K............p.c+K.cKK+....c..KKhKK+...sKc+t..........ptpt.......sc....s.h..Pssslct.hpcps..tpcp.s..sP................lhTDEQKSRlpAM+PMTKEEW-ARQSlIR+VVDPETGRTR..LI.KGDGEVLEE...I.VoKERH+EINK............................QAT+GDGhhFQh+s.sh.h.........
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