GenomeNet

Database: Pfam
Entry: SR-25
LinkDB: SR-25
Original site: SR-25 
#=GF ID   SR-25
#=GF AC   PF10500.6
#=GF DE   Nuclear RNA-splicing-associated protein
#=GF AU   Buljan M, Coggill P
#=GF SE   TreeFam_TF105478
#=GF GA   55.00 55.00;
#=GF TC   55.60 55.60;
#=GF NC   52.60 52.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10708573
#=GF RT   Molecular cloning and expression analysis of a putative nuclear
#=GF RT   protein, SR-25. 
#=GF RA   Sasahara K, Yamaoka T, Moritani M, Tanaka M, Iwahana H,
#=GF RA   Yoshimoto K, Miyagawa J, Kuroda Y, Itakura M; 
#=GF RL   Biochem Biophys Res Commun. 2000;269:444-450.
#=GF RN   [2]
#=GF RM   17952876
#=GF RT   Dominant negative Rac1 attenuates paclitaxel-induced apoptosis
#=GF RT   in human melanoma cells through upregulation of heat shock
#=GF RT   protein 27: a functional proteomic analysis. 
#=GF RA   Lee SC, Sim N, Clement MV, Yadav SK, Pervaiz S; 
#=GF RL   Proteomics. 2007;7:4112-4122.
#=GF DR   INTERPRO; IPR019532;
#=GF CC   SR-25, otherwise known as ADP-ribosylation factor-like factor
#=GF CC   6-interacting protein 4, is expressed in virtually all tissues.
#=GF CC   At the N-terminus there is a repeat of serine-arginine (SR
#=GF CC   repeat), and towards the middle of the protein there are
#=GF CC   clusters of both serines and of basic amino acids. The presence
#=GF CC   of many nuclear localisation signals strongly implies that this
#=GF CC   is a nuclear protein that may contribute to RNA splicing [1].
#=GF CC   SR-25 is also implicated, along with heat-shock-protein-27, as a
#=GF CC   mediator in the Rac1 (GTPase ras-related C3 botulinum toxin
#=GF CC   substrate 1) signalling pathway [2].
#=GF SQ   114
#=GS B4NBN5_DROWI/1-140        AC B4NBN5.1
#=GS S2JMY1_MUCC1/44-113       AC S2JMY1.1
#=GS F8WEP2_HUMAN/106-168      AC F8WEP2.1
#=GS U9UIE4_RHIID/20-251       AC U9UIE4.1
#=GS F7AKV2_MACMU/99-319       AC F7AKV2.1
#=GS H2NJ09_PONAB/188-397      AC H2NJ09.2
#=GS F1NPS9_CHICK/2-229        AC F1NPS9.1
#=GS E9IA81_SOLIN/265-431      AC E9IA81.1
#=GS F8WEP2_HUMAN/7-113        AC F8WEP2.1
#=GS H7BZV4_HUMAN/8-206        AC H7BZV4.1
#=GS F1N671_BOVIN/79-311       AC F1N671.2
#=GS G3I4Y5_CRIGR/7-250        AC G3I4Y5.1
#=GS H9GMK8_ANOCA/55-227       AC H9GMK8.1
#=GS I1FF50_AMPQE/1-203        AC I1FF50.1
#=GS H2TL99_TAKRU/4-216        AC H2TL99.1
#=GS M3W5C6_FELCA/115-345      AC M3W5C6.1
#=GS K7J4J7_NASVI/232-475      AC K7J4J7.1
#=GS F6XHN5_CALJA/7-223        AC F6XHN5.1
#=GS F7AKY6_MACMU/103-327      AC F7AKY6.1
#=GS D3BAZ8_POLPA/86-310       AC D3BAZ8.1
#=GS G1SDE5_RABIT/4-121        AC G1SDE5.1
#=GS H2TL98_TAKRU/5-244        AC H2TL98.1
#=GS A0A091DL34_FUKDA/9-230    AC A0A091DL34.1
#=GS F8WCT1_HUMAN/7-227        AC F8WCT1.1
#=GS L9KWG7_TUPCH/7-225        AC L9KWG7.1
#=GS G1MWR1_MELGA/1-182        AC G1MWR1.2
#=GS Q55D05_DICDI/52-271       AC Q55D05.1
#=GS B0W116_CULQU/75-207       AC B0W116.1
#=GS H3DEH5_TETNG/112-204      AC H3DEH5.1
#=GS Q9VCD4_DROME/1-136        AC Q9VCD4.2
#=GS W5KNW5_ASTMX/3-265        AC W5KNW5.1
#=GS A0A0C4DH18_HUMAN/117-179  AC A0A0C4DH18.1
#=GS F5GYV5_HUMAN/7-211        AC F5GYV5.1
#=GS F4PL70_DICFS/67-289       AC F4PL70.1
#=GS AR6P4_MOUSE/7-227         AC Q9JM93.1
#=GS G3RPC0_GORGO/216-420      AC G3RPC0.1
#=GS N6U249_DENPD/1-252        AC N6U249.1
#=GS A0A087XYX4_POEFO/1-237    AC A0A087XYX4.2
#=GS A0A096N078_PAPAN/209-333  AC A0A096N078.1
#=GS F6Y6B1_CALJA/7-215        AC F6Y6B1.1
#=GS A0A0C4DG62_HUMAN/7-216    AC A0A0C4DG62.1
#=GS B4JIG9_DROGR/1-150        AC B4JIG9.1
#=GS G1QPN8_NOMLE/128-356      AC G1QPN8.1
#=GS C3YDE1_BRAFL/1-67         AC C3YDE1.1
#=GS M7BMY5_CHEMY/7-226        AC M7BMY5.1
#=GS F4NXF9_BATDJ/85-174       AC F4NXF9.1
#=GS AR6P4_DANRE/3-219         AC Q502P0.1
#=GS F1Q2D4_CANFA/7-230        AC F1Q2D4.2
#=GS Q17BR7_AEDAE/3-171        AC Q17BR7.1
#=GS G5AWS1_HETGA/1-107        AC G5AWS1.1
#=GS H2TL97_TAKRU/4-204        AC H2TL97.1
#=GS L5LJC0_MYODS/7-229        AC L5LJC0.1
#=GS G1M944_AILME/61-286       AC G1M944.1
#=GS B3S4J7_TRIAD/18-146       AC B3S4J7.1
#=GS U3K3P1_FICAL/3-240        AC U3K3P1.1
#=GS M4ATH6_XIPMA/1-238        AC M4ATH6.1
#=GS F6YRL7_CIOIN/2-199        AC F6YRL7.2
#=GS Q4V5H0_DROME/2-70         AC Q4V5H0.1
#=GS B4QSG1_DROSI/1-136        AC B4QSG1.1
#=GS B4MBZ2_DROVI/1-135        AC B4MBZ2.1
#=GS W5MEH0_LEPOC/3-257        AC W5MEH0.1
#=GS I3K6J1_ORENI/80-182       AC I3K6J1.1
#=GS H2LP30_ORYLA/1-197        AC H2LP30.1
#=GS W5PAQ2_SHEEP/82-311       AC W5PAQ2.1
#=GS B0BMG4_XENTR/7-248        AC B0BMG4.1
#=GS AR6P4_CHICK/2-229         AC Q5F4A9.1
#=GS G6CUY9_DANPL/1-161        AC G6CUY9.1
#=GS B4K7D5_DROMO/1-143        AC B4K7D5.1
#=GS H0Z518_TAEGU/7-231        AC H0Z518.1
#=GS A0A096M1Q6_POEFO/1-199    AC A0A096M1Q6.1
#=GS E9G8W6_DAPPU/4-206        AC E9G8W6.1
#=GS M3XRI8_MUSPF/60-290       AC M3XRI8.1
#=GS G3UEC1_LOXAF/7-228        AC G3UEC1.1
#=GS T1FTS1_HELRO/2-148        AC T1FTS1.1
#=GS H9J9Y4_BOMMO/1-158        AC H9J9Y4.1
#=GS AR6P4_HUMAN/191-419       AC Q66PJ3.2
#=GS E9G8W5_DAPPU/3-204        AC E9G8W5.1
#=GS F1RFJ6_PIG/7-236          AC F1RFJ6.2
#=GS A0A093BP95_CHAPE/7-244    AC A0A093BP95.1
#=GS I3MFE9_SPETR/7-227        AC I3MFE9.1
#=GS AR6P4_RAT/7-229           AC Q4V8I5.1
#=GS D3Z6F1_MOUSE/34-226       AC D3Z6F1.5
#=GS U3I250_ANAPL/86-202       AC U3I250.1
#=GS A0A0C4DH18_HUMAN/7-124    AC A0A0C4DH18.1
#=GS G3WL28_SARHA/36-275       AC G3WL28.1
#=GS V4BEC1_LOTGI/1-67         AC V4BEC1.1
#=GS F6TAV8_ORNAN/7-235        AC F6TAV8.2
#=GS F5H7X4_HUMAN/130-307      AC F5H7X4.1
#=GS F6S524_XENTR/7-224        AC F6S524.1
#=GS H3BE34_LATCH/3-242        AC H3BE34.1
#=GS F6VBC1_HORSE/7-229        AC F6VBC1.1
#=GS G3P006_GASAC/2-241        AC G3P006.1
#=GS E2BI88_HARSA/1-124        AC E2BI88.1
#=GS A7USQ6_ANOGA/1-202        AC A7USQ6.2
#=GS B4HGH6_DROSE/1-137        AC B4HGH6.1
#=GS L5KS64_PTEAL/7-220        AC L5KS64.1
#=GS T1GW67_MEGSC/81-149       AC T1GW67.1
#=GS B4G424_DROPE/1-134        AC B4G424.1
#=GS W4YHG3_STRPU/421-671      AC W4YHG3.1
#=GS F4WVX6_ACREC/74-246       AC F4WVX6.1
#=GS H0XEC0_OTOGA/59-266       AC H0XEC0.1
#=GS F6XIW1_CALJA/7-234        AC F6XIW1.1
#=GS A0A067QJQ7_ZOONE/1-194    AC A0A067QJQ7.1
#=GS E2A8S0_CAMFO/132-444      AC E2A8S0.1
#=GS H2Q752_PANTR/130-358      AC H2Q752.1
#=GS H0W757_CAVPO/66-182       AC H0W757.1
#=GS A0A087ZPZ8_APIME/259-417  AC A0A087ZPZ8.1
#=GS D3YWC2_MOUSE/4-198        AC D3YWC2.1
#=GS A0A0D9S520_CHLSB/130-350  AC A0A0D9S520.1
#=GS D6WEC8_TRICA/89-164       AC D6WEC8.1
#=GS G3SW00_LOXAF/68-184       AC G3SW00.1
#=GS Q298K4_DROPS/1-134        AC Q298K4.1
#=GS J9P4L0_CANFA/50-281       AC J9P4L0.1
#=GS B3LWY8_DROAN/1-137        AC B3LWY8.1
B4NBN5_DROWI/1-140                   ............................................................mg-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..----SDK........................KKK.KHKH.KR..K..EHKEKHKT.......RKSKKHE.KHRR....E.RSKDNE.....TS..VSQ.....-P.AAT..................ANPPQA.....ES.GDEd..fAIPIALM...N.......SKS-..-.....--HA.PETPEEYQRRQSQIRREVDPVTGRIR..LIKGDSEIL.....EEIVSKDRHTEINK............................K.AT..RSDGEYYE-----ahsl.........
S2JMY1_MUCC1/44-113                  ...........................................................atd-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....KAMI.PMTKNEYEKKRSIITTEYDAQTGRMR..RKRATGEIL.....ESIVTKEQHLKINK............................M.ST..LMDGLSYQRQ---v............
F8WEP2_HUMAN/106-168                 .............................................................g-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....----.---KEKAEAQQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDCLAFQMRAGL.............
U9UIE4_RHIID/20-251                  ................................................sevrsylpererdn-------NFKR........-KRGNSPRSYSI....SRSH.S.RSHSRshS......RSHSRSHS.RSRSPKK........KKSKSKSKhRKHK..NHH....SSS.KDDS..LS.Y...S.TDTT....NS..IDISRHH........................HKS.KSKK.KH..K..KHKKFKKK.......KHEEKGE.KEHHl..iQ.EIKEWQ.....QNlrKKK.....DP.IQS..................TNSVIH.....QE.EEE....------L...E.......KKPK..R.....PSMM.PQTRKEYEAEQSVIREVVDPVDGRVR..LIRGSGEVI.....ERIVSKEEHKRINR............................Q.AT..MGDSLTYQK----nw...........
F7AKV2_MACMU/99-319                  ..............................................repgrgssgklhlcsg-----------........------KPRRRR....SPCR.C.RGRRF..T......SSPPGLLA.SPSPCIT........ERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..KRRRKKK-.......--KKKLK.KKGK....E.--KVEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
H2NJ09_PONAB/188-397                 ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDA.S.RNCSA..S......TSQE----.-------........-RSKQKAR.RRPR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..KRKKKKR-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
F1NPS9_CHICK/2-229                   ..........................................................argr-SRKRSRSSSR........SPSGSG--REKG....G--A.-.RRSAA..S......PGPRHRLS.SAAAREG........RKKEGRKK.KKRK..GKA....SSS.DRSS..SS.R...S.SSSS....SS..TSSSDSDtra.................kqhsRRK.RGKH.KD..K..KKKKKM--.......--KKKLK.KKSK....E.RVKEER.....GV..SEA.....LP.GPS..................LELWQK.....EP.LAE....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
E9IA81_SOLIN/265-431                 ...........................................................shv-----------........------------....----.-.-----..-......--------.-------........--------.----..-SS....SSS.SSSS..SD.T...D.SSSS....SS..SIDSSENe......................rKQK.KAKK.KA..K..KLKKAMKK......rKKKKRMK.KKLK....K.KLKKSA.....TK..KKG....hGK.KKS..................KENKQV.....QD.GKE....KAKEIVL...D.......VTER..A.....KVMA.PMTKEEWEKRQSIVRRIYDEETGRHR..LIKGDGEVL.....EEIVSRERHKDINR............................Q.AT..KGDGKYFQ-----.............
F8WEP2_HUMAN/7-113                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQER---.-------........--SKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.KAEA--.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....----.--------------------------..---------.....--------------............................-.--..-------------q............
H7BZV4_HUMAN/8-206                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQER---.-------........--SKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................-.--..-------------vgvap........
F1N671_BOVIN/79-311                  ..............................................................RKRSRSRSRSR........-GRGSEKKRKKS....SKDV.R.RSCSA..S......RSQSRKAS.STSSGAEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKK-.......KRKKKLK.KRGK....E.--KARM.....QQ..TEA.....LP.GPS..................LDQWHR.....AA.KEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTRplLPIGWSRQL.....QGLVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
G3I4Y5_CRIGR/7-250                   ..............................................................RKRSRSRSRSR........GRRGSEKRSKKS....SKDA.S.KNCSA..S......KSPGHKAC.STSE---........ERSKHKAR.RTAR..---....--S.SSSS..SS.S...S.SSSS....AS..SSSSSDG........................RKK.RGKN.KD..K..KRKKKKK-.......-RKKKLK.RKGK....E.--KAVV....lHP..AEA.....LP.GPS..................LDQWHK.....SA.GED....DGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINKvgvtalamlcprcvytqylmlltcflpqQ.AT..RGDGLAFQMRAGL.............
H9GMK8_ANOCA/55-227                  .............................................................s-----------........------------....----.-.-----..-......--------.-------........--------.----..--E....STS.HSSG..SS.S...D.SSDS....SP..-EESSDGesrpk..............rkkpsKKK.LAKG.KD..K..KEKKRKRK......rKAKKKAK.KKMK....E.--KEGK.....TR..LEE.....LP.GPS..................LDQWQR.....ET.VAD....PGPALTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVTDPETGRTR..LIKGDGEVL.....EEIVTKERHKEINK............................Q.AS..RGDGLTFQMRTGM.............
I1FF50_AMPQE/1-203                   .......................................................msssssl-----------........------------....----.-.-----..-......--------.SSSESEG........ERREKRRK.RKRK..---....-IE.KDSS..LS.E...E.SSSS....DG..GQRVILKkkkrkkekgk....ddssftsfqaK--.KKKK.HS..K..SSKRHNKE.......KHKKSKK.KKSK...dN.KSNLDW.....SN..AIQ.....LS.APP..................VPSAP-.....PP.PID....TTPLITT...H.......PPLK..-.....RSYG.PMTQFDYVKQQSVVRRVVDPETGRSR..LVKGDGEII.....EEIVSRDRHKAINK............................L.AT..QGDGLSFQT----gl...........
H2TL99_TAKRU/4-216                   ...........................................................imn----RSSSHDRs.....irENKTEPKKRRRS....SSSS.S.SSSSS..S......RSR--NV-.-------........-----KTK.KKRR..RSS....SSS.STSS..SS.S...S.S--S....SS..NEKTKRK........................KSK.KSKA.KK..K..KAKLKKQN.......KKEKKKK.QKLK....K.KTKAAA.....AA..AAAa...aAA.AVA..................VELWQS.....-D.EVE....LGPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRRVVDPETGRTR..LIRGEGEII.....EEIVSREQHKDINK............................Q.AT..KGDGNTFQKKLGI.............
M3W5C6_FELCA/115-345                 ..............................................................RKRSRSRSRSR........-ERGSEKRRKKS....SKDV.P.KSCSA..S......RSQDHKAS.TISSGAEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSGG........................RKK.RGKH.KD..K..KRKKKKKK.......KRKKKLK.KKGK....E.--KTKV.....QQ..GEA.....LP.GPS..................LDQWHR.....SA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..-RRGDGCCA.....KKPKTGEGHREINK............................Q.AT..RGDGLAFQMRAGL.............
K7J4J7_NASVI/232-475                 ...................................................rsqpkssdser------VRETR........TSREQKKFEDRG....RAEK.T.PELSP..E......PKPVEEERiDLADLEI.......eKPIPEKKK.RKKR..SRS....SSS.SSSSasSS.S...S.DSDS....SD..SNDSSDDssss................ssssSEE.DKKK.KK..K..KKLAKKLK.......KKEKKKK.KKKK....K.--KLKK.....KL..SKK.....VK.NSA..................SEEKKL.....ST.KMD....NDRLLNDialE.......QSLR..S.....KAMA.PISKKEWEKRQNVVRRIYDEESGRHR..LIKGDGEVI.....EEIVNRDRHKQINN............................Q.AT..RSDGEYFQSQ---lr...........
F6XHN5_CALJA/7-223                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......ESQASPSP.CIT----........ERSKHKAR.RPR-..--S....SSS.SSSG..SS.S...S.SSSS....SS..SSSSSGG........................RKK.RGKH.RD..K..RRRRKKK-.......KKRKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
F7AKY6_MACMU/103-327                 .................rgssgklhlcsgkprrrrspcrwsvpapgqsrgrrftssppglla-----------........------------....----.-.-----..-......--------.------Spsp..citERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..KRRRKKK-.......--KKKLK.KKGK....E.--KVEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
D3BAZ8_POLPA/86-310                  ..............................................................RSRSRSRSIDR........KHHRYDKDRLRS....RSNS.-.RSRST..S......RGKDRSTK.RHKKHRGg.....grDRSKSRSR.SRSR..QRSkerkNRH.RH-R..SR.S...S.SSST....SS..SSSSSED........................QAE.RKKR.KD..K..RKEEKKKR.......REERKSK.DKARs..rD.KVKEKV.....KE..KDK.....-E.KES..................KDNSSK.....SN.NKI....TTQQQQQ...Q.......QTSQptK.....RVMG.PMSNEDYETLRNTTYEKYDEDTGRVR..VYRGTGELI.....ERIVTKEQHKAINY............................I.AT..H------------hp...........
G1SDE5_RABIT/4-121                   ................................carsthtpsqarartvffsppgppspppgv-----------........------------....----.-.-----..-......--------.------T........ERSKHKAL.RRAC..CSS....PSS.SSSS..SS.-...P.ASSS....SS..SSSSSSS........................SSS.RGRK.KR..G..KHRHKKR-.......---KKRK.KRRK....L.KEKAEA.....QP..PEA.....LP.GPS..................LDQWHR.....S-.---....-------...-.......----..-.....----.--------------------------..---------.....--------------............................-.--..-------------.............
H2TL98_TAKRU/5-244                   ............................................................mn----RSSSHDRs.....irENKTEPKKRRRS....SSSS.S.SSSSS..S......RSRSKSSK.KSSH---........KNKDVKTK.KKRR..RSS....SSS.STSS..SS.S...S.SS--....SS..NEKTKRK........................KSK.KSKA.KK..K..KAKLKKQN.......KKEKKKK.QKLK....K.KTKAAA.....AA..AAA.....AA.AAAvavlpslpspaavkppsyPELWQS.....-D.EVE....LGPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRRVVDPETGRTR..LIRGEGEII.....EEIVSREQHKDINK............................Q.AT..KGDGNTFQKKLGI.............
A0A091DL34_FUKDA/9-230               ..............................................................RKRSRSRSRSR........-GRGSEKRRKKG....SKDV.W.RNYTT..S......GSQGRRAS.TASG-AE........ERSMHKAR.RRPR..SSS....SSC.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKRKRK-.......-KKKKLR.KKGK....E.--KVEV.....QQ..AEA.....LP.GPS..................LDQWHR.....SA.GEE...dGGPVLTD...E.......QKSR..V.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVTKERHRAINK............................Q.AT..RGDGLAFQMRAGL.............
F8WCT1_HUMAN/7-227                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQGRKAS.TAP-GAE........ERSKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDCLAFQMRAGL.............
L9KWG7_TUPCH/7-225                   ..............................................................RKRSRSRSRSR........-GRGSEKKRKKS....SKGS.S.GKCSA..S......ESRGRKAS.TSC-GAE........ERSKHKAR.RRPR..SSS....SSC.PSSS..SSsS...S.SSSS....SS..SSSSSAG........................RKK.RGKH.KD..K..KRKKKKK-.......-----LK.KKGK....E.--KAAV.....PQ..AEA.....LP.GPS..................LDQWHR.....SA.GEE...eEGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPATGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
G1MWR1_MELGA/1-182                   ............................................................gr-----------........------------....----.-.-----..-......--------.-------........-KKEGRKK.KKRK..ANA....SSS.DSSS..SS.R...S.SSSS....SS..TSSSDSDtra.................krhgRRK.RGKH.KD..K..KKKK----.......KTKKKLK.KKSK....E.RVKEDR.....GV..GEA.....LP.GPS..................LELWQK.....EP.QAD....PGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
Q55D05_DICDI/52-271                  ............................................................lyRDRSKSRERDR........INTKHDKNNLE-....-IDK.K.RNTER..D......ENKYRDRD.KNRGRSR........SRSKSRER.YKKY..KRN....RSR.SSSS..SS.S...S.SSSS....SS..SSSSSNErk....................krKKK.KKEE.KR..K..RKKEKKEK.......KEEKELK.KKLK....K.DSKKSS.....ST..VST.....TT.TTT..................TTAAAA.....SA.TNT....SNLVNNN...N.......NKK-..-.....-KMG.PISDEDYEKLKNSYREVFDEDSGRTR..VVNGNGEIV.....ERIVSREQHKAINY............................I.AT..H------------hptq.........
B0W116_CULQU/75-207                  .............................................................q-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.---K.KE..A..KRERKLAK.......AQRKALK.KQQK....E.ERKAEK.....RR..RKE.....LK.RQKr................pTDATCS.....ST.TVD....CGVPL-D...L.......MNTR..-.....-ARA.PETREEYEARQAIVRRVLDPETGRSR..LVKGDGEII.....EECVSRERHMDINR............................Q.AT..AGDGAEFQRK---svg..........
H3DEH5_TETNG/112-204                 ..................................................dpslnapicgqe-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-IPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRKVVDPETGRTR..LIRGEGEII.....EEIVSREQHKDINK............................Q.AT..RGDGNAFQRKLGI.............
Q9VCD4_DROME/1-136                   ...........................................................mgk-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-----SE........................KKS.KKKH.KE..K..RREHKEK-.......HKSKKSK.KHNR....K.---KEE.....SP..PIA.....SP.TPI.................qPERVNQ.....EE.EDD...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRKEVDPVTGRVR..LIKGDSEVL.....EEIVTKERHLEINK............................K.AT..RGDGEFYEAR---s............
W5KNW5_ASTMX/3-265                   ..............................................................RSRSRSRSRERkstsrqgrERRTEKKRRKYS....SSSS.-.SSSSA..S......PSSQKKHG.RVSNKSMs......kDRKTERKK.QKRR..RSS....SSS.SSSS..SS.S...S.SSSS....SS..ISSSSSTsss..................deeAKK.KKKH.RM..T..KKRLKKMKak...kkKKEKKEK.KRLKkikkL.AAKAEK.....AA..TKApliipVP.GSVqvek..........tqsyLETWQN.....DD.AAE....HGPVMTD...E.......QKAS..F.....STKR.PMTKEEYEARQSVIRRVTDPETGRTR..LIRGDGEVL.....EEIVSKERHKDINK............................Q.ST..KADGTTFQKRLGI.............
A0A0C4DH18_HUMAN/117-179             .............................................................g-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....----.---KEKAEAQQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDCLAFQMRAGL.............
F5GYV5_HUMAN/7-211                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQGRKAS.TAP-GAE........ERSKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................-.--..-------------.............
F4PL70_DICFS/67-289                  ..........................................................rkrsRDRSRARSKSR........DRSDRDRYRQRS....RSRS.-.RDKST..S......NNVDKRER.DDDKENR.......vKKRKSRSK.SRSR..SRS....RSI.SSSS..SS.S...Y.DSSS....DS..SSSSSEE.......................rRRK.RKKK.KR..K..EKKEKKQR.......KKEKKEK.KKLK....E.QQELEE....lEK..KKQ.....LE.RQM..................AMERQQ.....QK.QQQ....QQELETN...T.......PPKR..-.....-VMG.PISNESYDKLRNTFVEKYDEDTGRMR..VYRATGELI.....ERVVSKEKHKEINY............................I.AT..H------------hptk.........
AR6P4_MOUSE/7-227                    ..............................................................RKRSRSRSRSR.......sGRRGSEKRSKRS....SKDA.S.RNCSA..S......RSQGHKAG.SASGVE-........ERSKHKAQ.RTSR..---....-SS.STSS..SS.-...S.SSSS....AS..SSSSSDG........................RKK.RAKH.KE..K..KRKKKKK-.......KRKKKLK.KRVK....E.-KAVAV.....HQ..AEA.....LP.GPS..................LDQWHR.....SA.GED...nDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRTGL.............
G3RPC0_GORGO/216-420                 .....................csgkplrkrspcrrsvpapgqsrgrrftsyppglpaspspc-----------........------------....----.-.-----..-......--------.-----IT........ERSKQKAR.RRPR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................-.--..-------------vgva.........
N6U249_DENPD/1-252                   .................................mqkdkkvksktkkvlvksqrrkicdevfs-----------........----SSESLKRI....SDCD.R.KNNTS..S......DEACWKA-.-------........KKSKRSKV.KKRD..SST....SSY.SSSS..SS.S...E.SSSS....SS..SSSSSSTtss.................sddnRKR.KKKN.IA.iL..KRKLKQKKeeklnsrRRQSGKK.KRSKlvtdK.DLNKEK....sEE..NDM.....KR.KTK..................AKKNEK.....EE.AAE....ASNDIPI...E.......LMDR..S.....KAMA.PMRKEEWEKKQNVVKRVYDEETKRHR..LIKGDGEVI.....EEIVSKERHKDINK............................Q.AT..KGDGEYFSSK---lt...........
A0A087XYX4_POEFO/1-237               ............................................................mn--RSRSSERVT.......rEKTTEKKKRRRS....SSSS.-.SSSSS..S......SSRSRSAK.KISSKKK.......sSDGKEQQK.RRRT..RSS....SSS.STSS..S-.-...-.SSSS....SS..SSCSSDE........................RRK.RKKS.KA..K..KKLKKQKAk....lkKQRKKEK.KKLK....K.KEKKLR.....KE..VEA.....LQ.RPPdkp............psyLEAMQN.....EE.EEEe.eeLGPVMTD...E.......QKAR..L.....ATKR.PLTKEEYEARQSVIRRVVDPETGRTR..LVRGEGEII.....EEIVTREKHKDINK............................Q.AT..KGDGNAFQRKLGM.............
A0A096N078_PAPAN/209-333             .........................................................pcite-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......--RSKHK.ARRR....P.RSSSSA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKDRHREINK............................Q.AT..RGDGLAFQMRAGL.............
F6Y6B1_CALJA/7-215                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......ESQERSK-.-------........----HKAR.-RPR..--S....SSS.SSSG..SS.S...S.SSSS....SS..SSSSSGG........................RKK.RGKH.RD..K..RRRRKKK-.......KKRKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
A0A0C4DG62_HUMAN/7-216               ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQER---.-------........--SKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDCLAFQMRAGL.............
B4JIG9_DROGR/1-150                   ..........................................................mgks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..------D........................KKA.KKKH.KS..E..RKQHKEKNkd..kvkKSRKHEKaKKPK....E.SPSAAN....nEM..APA.....IP.PPNpp..............gqTATADS.....GS.EED...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRREVDPVTGRTR..IIKGDSEIL.....EEIVSKQRHGDINR............................K.AT..SGDGEYFEA----qs...........
G1QPN8_NOMLE/128-356                 ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDA.S.RNCSA..S......TSQGRKAS.TASGAEAsps.pcitERSKQKAR.RRPR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.RT..R..RGGRRRK-.......--RKKLK.KKGK....E.--KAEA.....QQ..MEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
C3YDE1_BRAFL/1-67                    ..............................................................-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....--MR.PMTKEEWDKQQSVVRRVFDPDTGRNR..LVKGDGEII.....EEIVSKERHKQINQ............................Q.AT..QGDGLSFMRGLGL.............
M7BMY5_CHEMY/7-226                   ..........................................................rkrsRSRSESDSQSR........QDKKDEKKRRKS....SKDS.K.KSSQS..PprkkaaRSHRCRSS.SAS-TKE........EKKKAKDK.KRKK..AST....SSS.ETTS..SS.S...G.TSSS....SSssSDDSS-Dnesk................lkkrR--.HSKK.KR..TkqKDKKRKKK.......KIKKKLK.KKSK....D.RPKEER.....AM..VEG.....VP.GPS..................LEQWQK.....ES.LVE....PGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..V--------.....--------------............................-.--..-------------rlnfvkaiskfan
F4NXF9_BATDJ/85-174                  ...........................................piqtlastssqslnktrvt-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......---K..R.....SAMM.PMSQKEYLAEQSTIRKVYDQETGRTR..TIRGSGEVI.....EEIVSRSQQKAINT............................A.ST..ASDGAVFM-----hgltl........
AR6P4_DANRE/3-219                    .............................................................g-SDSDSRSRSR........-NREENKSRSLS....SSSA.-.--RRP..S......PNHEKKH-.-------........EHSSEKKK.MKRR..RSS....SSS.SSSS..SP.S...P.S---....--..REKKAKK........................KKK.RREA.KK..L..----KREK.......KKEKKEK.KRQKk.laL.KAERAA.....AL..TAS.....VP.APVpeek..........pqtyLKTWQS.....EE.TKE....HGPAMTD...E.......QKAK..L.....STRR.PLTKEEYEARQSVIRRVLDPETGRTR..LIRGDGEIL.....EEIVSKERHKDINK............................Q.ST..RGDGDAFQKRLGI.............
F1Q2D4_CANFA/7-230                   ..............................................................RKRSKSRSRSR........-GRGSEKRRKKS....SKDA.P.RSCSA..S......RCQDRKAI.ITSSGAE........ERSKHKAR.RRPR..-SS....SSS.SSSG..SS.S...S.SSSS....SS..SSSSSGD........................RKK.RGKH.KD..K..KRRKKKR-.......KRKKQLK.KKGK....E.KA-KLQ.....QQ..GEA.....LP.GPS..................LDQWHR.....SA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
Q17BR7_AEDAE/3-171                   .........................................................pqdes-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.--DG....SS..SRSSSPD........................RKKsKKSR.RD..E..RKEKKRLKka...lkKEAKRER.KEAK....A.KRRALKk...qER..EQR.....KA.EKR..................LRKQQK.....KE.QGR....SEPAAIA...GadcgvplDLMN..T.....QARA.PETREQYEARQAVVRRVVDPETGRTR..LVKGDGEIL.....EECVSRDRHLEINR............................Q.AT..AGDGAEFQRKT--ig...........
G5AWS1_HETGA/1-107                   .............................................................m-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.----EV.....QQ..AEA.....LP.GPS..................LDQWHR.....SA.GEE...dSGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
H2TL97_TAKRU/4-204                   ...........................................................imn----RSSSHDRs.....irENKTEPKKRRRS....SSSS.S.SSSSS..S......RSR--NV-.-------........-----KTK.KKRR..RSS....SSS.STSS..SS.S...S.S--S....SS..NEKTKRK........................KSK.KSKA.KK..K..KAKLKKQN.......KKEKKKK.QKLK....K.KTKAAA.....AA..AAAa...aAA.AVA..................VELWQS.....-D.EVE....LGPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRRVVDPETGRTR..LIRGEGEII.....EEIVSREQHKDINK............................-.--..-------------llim.........
L5LJC0_MYODS/7-229                   ..............................................................RQRSRSRSRSR........-GRGSEKRRKKS....SKDA.R.GSCSA..S......RSHGRKAS.TTSSGAE........ERSKHQAR.RRRR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSHG........................RKK.SGKY.KD..K..KRKKKKK-.......RRRKKLK.KKGK....E.--KAEA.....RP..PEA.....LP.GPS..................LDQWHR.....PA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTREEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
G1M944_AILME/61-286                  ............................................................la---SKSRSRSR........-GRGSEKRRKKS....SKDA.P.RSCSA..S......RSQDHKAG.NTSSGAEaspspcitERSKHKAQ.RRPR..-SS....SPS.SSSS..SS.S...S.SSSS....SS..SSSSSGG........................RKK.RGKH.KD..K..RRRRRKK-.......KRKKQLK.KKTK....E.--KAKL.....QQ..GEA.....LP.GPS..................LDQWHR.....SA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..--WGVLAKL.....SP--TCSRHREINK............................Q.AT..RGDGLAFQMRAGL.............
B3S4J7_TRIAD/18-146                  .....................................................qclnknkrk-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-HSSEDS........................HEK.KKHS.KK..K..SKKNKKDK.......KSAKKEK.RKDK....K.-YKNSQ.....DA..DDA.....--.--A..................AKTSQK.....--.DAS....TGPV---...E.......QQKN..F.....---A.PMTKEEWDKQQSVIRRVYDPETGRNR..LIKGSGEIL.....EEIVSKEQHQRINK............................-.--..-------------vcla.........
U3K3P1_FICAL/3-240                   ............................................................hg--RSRKRSRSR........---SRSRSNSRS....RQER.K.ERKKI..S......GSHGHKSS.LAAAKEE........KKKEGKDK.KKRK..AST....SSS.GNSS..ST.S...S.SSSS....SS..SSSSSDDssdsdsk..........mkksqdsKKK.RVKQ.KD..K..KKRKKKKK.......KIKKKSK.KKAK....E.RAKEEK.....GK..GEE.....VP.GPS..................LEQWQK.....ES.GLD....PGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
M4ATH6_XIPMA/1-238                   ............................................................mn--RTRSSDRDT.......rEKKTEKKKRGRS....SSSS.SsSSSSS..S......RSRSAKKI.SSTKKKM........TDGKEQRK.RRRT..RSS....SSS.STSS..SS.S...P.SSSS....S-..----SDE........................KRK.RKKS.KA..K..KKKLKKQKak...lkKQRKKEK.KKLK....K.KEKKLK.....KE..VEA.....MQ.RPPekp............psyLEVMQN.....EE.EEEdeveLGPVMTD...E.......QKAR..L.....ATKR.PLTKEEYEARQSVIRRVVDPETGRTR..LVRGEGEII.....EEIVTREKHKEINK............................Q.TT..MGDGNAFQRKLGM.............
F6YRL7_CIOIN/2-199                   ................................................gskkekkdvrevvh-----------........------------....----.-.---KV..K......KAKHEKKS.EDSNKRS........YFSSTSKK.RKKR..YSS....SSC.STDS..ER.K...V.KKKK....RK..RTTSEDT........................--S.SSED.RT..Q..KTLKRKKA.......KHKKKTK.KKKM....K.KEKTIK.....TT..DEN.....SP.-KN..................IKSLKK.....NK.EET....ADP----...-.......-DPR..A.....LAMR.PMTQEEWEKRQSVMRHVYDAETGRTR..LVKGDGEIM.....EEIVSRERHLAINK............................Q.AT..IGDGNSFQAK---.............
Q4V5H0_DROME/2-70                    ..........................................................nsks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....--HA.PETPEEYQRRQSQIRKEVDPVTGRVR..LIKGDSEVL.....EEIVTKERHLEINK............................K.AT..RGDGEFYEAR---s............
B4QSG1_DROSI/1-136                   ...........................................................mgk-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-----SE........................KKS.KKKH.KE..K..RREHKEK-.......HKSKKSK.KHSR....K.---KEE.....SP..PIA.....SP.SPI.................qPERVNQ.....EE.EDD...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRKEVDPVTGRVR..LIKGDSEVL.....EEIVTKERHLEINK............................K.AT..RGDGEFYEAR---s............
B4MBZ2_DROVI/1-135                   ..........................................................mgks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..------D........................KKS.KKKH.KS..K..RKEHKEK-.......---HKDK.AKKS....K.RQEKKD.....TP..PPK.....IE.TPL..................VAAADS.....GS.EED...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRREVDPVTGRTR..LIKGDSEIL.....EEIVSKQRHCDINR............................K.AT..SGDGDYFEA----qs...........
W5MEH0_LEPOC/3-257                   ....................................................rsrsrdqslg----------Rses.rqarEKKEAKKKRQRScsssSSSS.S.SSSST..S......PSPKRKSR.RPSSKKP........DDKRDKTK.AKRK..RSS....FSS.SSSS..SG.S...S.SSSS....AE..SSDSEAK........................RKR.KAKR.RL..K..KIKAREKKekr.kekKKQKKMK.KKMK....K.-LKKRM.....EK..AEK.....AA.VPQtpalll......dkaptaLETWQS.....EA.SVE....LGPVMTD...E.......QKAR..I.....ATKR.PMTKEEWDAKQSVIRRVVDPETGRTR..LVRGEGEVL.....EEIVSKDRHKEINK............................Q.AN..IGDGLSFQKRLGM.............
I3K6J1_ORENI/80-182                  ..........................................................npae-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....KP.PSY..................LEVWQT.....EEgAVE....LGPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRRVVDPETGRTR..LVRGEGEII.....EEIVSREKQKEINK............................Q.AT..KGDGDAFQRKLGI.............
H2LP30_ORYLA/1-197                   ............................................................mg--RSRSPSKDV.......rEKKQMKKKRRKS....SSSSsS.TSSSS..S......RSRSRSSK.KKTHKKK........QDLNTKRK.KRRT..RSS....SSS.STSS..S-.-...-.SSST....SS..SSSSSDE........................RSR.KKKM.KA..K..KKKLMKKKa....elKKQKKME.KKQK....K.IKKREK.....KM..KKE.....LEvGTVqipae.......nqppsyLEVWQN....dEE.AVE....LGPVMTD...E.......QKAR..L.....STKR.PLTKEEYEARQSVIRRVVDP------..---------.....--------------............................-.--..-------------.............
W5PAQ2_SHEEP/82-311                  ..............................................................RKRSRSRSRSR........-GRGSEKKRKKS....SKDA.R.RSCSA..S......RSQSRKAS.ITSSGAEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKK-.......-RKKKLK.KRGK....E.--KARM.....QQ..AEA.....LP.GPS..................LDQWHR.....AA.KEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERQREINK............................Q.AT..RGDGLAFQMRAGL.............
B0BMG4_XENTR/7-248                   ............................................................kkRSRSRSPKVSQ........-SKSSKKKKKLS....SRCR.-.---SS..S......DSPVRKHS.TLAKYRAev....pdRRKKERRK.KKRR..RTV....STT.SSSS..SS.S...E.SSSS....SS..SSCSSSDdsv.................dsscKSK.KSSH.RK..K..KTKKQMKKkk...akKKSKKLK.KKTSf.klE.CQDAKG.....TA..KEV.....LP.GPS..................INPCQK.....ES.PED....TGPALTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRMR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.ST..QKDGLAFQMHSGM.............
AR6P4_CHICK/2-229                    .........................................................argrsRKRSRSSSRSP........SGSGREKGG---....----.A.RSSAA..S......PGPRHRLS.SAAAREG........RKKEGRKK.KKRK..AKA....SSS.DRSS..SS.R...S.SSSS....SS..TSSSDSDtra.................kqhsRRK.RGKH.KD..K..KKKKKM--.......--KKKLK.KKSK....E.RVKEER.....GV..SEA.....LP.GPS..................LELWQK.....EP.LAD....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
G6CUY9_DANPL/1-161                   ....................................................mgkekakkrr-----------........------------....----.-.-----..-......--------.-------........--------.---H..---....ST-.----..--.-...-.SESS....SS..SSSSDSS........................REK.KKLR.KL..K..KKLKKEQK.......KTEKLLK.KKLK....E.EKKKLK.....RK..QSE.....ER.SQN..................QEKTK-.....--.-DE....ASSDIPL...E.......LMEK..S.....KAMA.PMTKEEWEKRQSVIRRVQDEETGRYR..LIKGDGEVI.....EEIVSRDRHKEINR............................Q.AT..MADGNFFQLQTG-q............
B4K7D5_DROMO/1-143                   ..........................................................mgks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..------E........................KKS.KKRH.KS..K..RKEQKEKH......kIKSRKSK.REDK....I.KLKQAK.....EE..TPV.....VD.EIS..................LQVAAAa...dSG.GEDd..fAIPIALM...N.......SKS-..-.....--HA.PETPEEYQRRQSQIRREVDPVTGRTR..LIKGDSEIL.....EEIVSKERHCDINK............................K.AT..SSDGAYFES----qs...........
H0Z518_TAEGU/7-231                   ..........................................................rkrsRSRSKSHSRSR........-QERKEKKRRKS....SKDS.Q.QGGSS..P......RARGEKRV.PGSR---........-----KDK.KKRK..AST....SSF.GTSS..ST.S...S.SSSS....SS..SSSSSDDs.....................nsKKK.QVKQ.KD..K..KKRKKKKK.......KIKKKSK.KKAK....E.RAKEEK.....AK..GEE.....VP.GPS..................LEQWQK.....ES.VVD....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
A0A096M1Q6_POEFO/1-199               .........................................................mnrsr-----------........------------....----.-.-----..-......--------.-SS-ERV........TREKTTEK.KKRR..RSS....SSS.SSSS..SS.S...S.RSRSakkiSS..KKKSSDGk......................eQ--.QKRR.RTssD..ERRKRKKS.......KAKKKLK.KQKA....-.KLRKEV.....EA..LQRp..pdKP.PSY..................LEAMQN.....EE.EEEe.eeLGPVMTD...E.......QKAR..L.....ATKR.PLTKEEYEARQSVIRRVVDPETGRTR..LVRGEGEII.....EEIVTREKHKDINK............................Q.AT..KGDGNAFQRKLGM.............
E9G8W6_DAPPU/4-206                   ........................................................iitngs-----------........------------....RSVS.K.KSVLE..S......KQKRKKEK.KSKKSLKe.....kiSRKKHSKK.KSRK..RHS....SSS.SDSS..SS.S...S.S-SS....SS..LKSSEDE........................KAK.KRKK.KN..K..KSKAKKQ-.......----KAK.LEA-....N.NVKAVI.....TE..IQL.....TL.PVS..................VSQTKP.....TL.ETN....VGPHI-D...L.......NSSK..M.....RA--.PMTKEEYEKQQNTLKWIVDPETGRRR..LIRGSGEIM.....EEIVSRERHQAINK............................Q.AT..VADGNFFQAQA--nl...........
M3XRI8_MUSPF/60-290                  ..............................................................RKRSKSRSRSR........-GRGSEKRRKKS....SKDA.A.RSCSA..S......RSQDHKAS.NTSSGVEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKK-.......KRKKKLK.KKSK....E.--EVKL.....QQ..GEA.....LP.GPS..................LDQWHR.....SA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
G3UEC1_LOXAF/7-228                   ..............................................................RKRSRSRSRSR........-GRGAEKRRQKR....SKDS.P.RSCSA..S......RSQGRKAS.TAP-GAE........ERSKHKAR.RKPR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RRKH.KD..K..KRKKKKR-.......-RKKKLK.KKNK....E.--KAKV.....QQ..AEA.....LP.GPS..................LDQWHR.....AA.AEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
T1FTS1_HELRO/2-148                   ....................................................krkrenedgn-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.SE..K..KKKKKKK-.......HKKKKSS.SRSSssssG.EDSHSD.....KC..SDV.....LV.GPEp...............gkLILIQS.....SQ.LQK....QKDPKTK...E.......CSRI..M.....KKMKtPMTKEEWDKEQKKLKRIYDPETGRNR..LIRGSGEVM.....EEIVSKKRQKEINK............................N.AT..TNDGQFY------lksa.........
H9J9Y4_BOMMO/1-158                   .....................................................mgkeksrkk-----------........------------....----.-.-----..-......--------.-------........--------.--KR..---....---.--SS..--.S...E.SSS-....-S..SSSSDSS........................REK.KRIR.KL..K..KKLRKEQK.......KTEKIIK.KKLK....K.EKKR--.....LK..KEY.....LK.-RS..................QSRDKS.....PE.VSA....DIPVEL-...-.......-MEI..S.....KAMA.PMTKEEWEKKQSIIRRVLDEETGRYR..LIKGDGEVL.....EEIVSKERHKEINR............................Q.AT..QADGALFQAQ---tl...........
AR6P4_HUMAN/191-419                  ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQGRKAS.TAPGAEAsps.pcitERSKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDCLAFQMRAGL.............
E9G8W5_DAPPU/3-204                   ...................................................qitagkslvsk-----------........------------....-SDV.-.--ERK..L......KSKKGKKS.KKSSKEK........PRKSHSKK.KSRK..RHA....SSS.SDSS..DS.S...S.SSSS....S-..-ESSENE........................KAK.KRKK.KS..K..KSKAKKQ-.......------K.AKLE....-.-ATKAK.....AV..IEK.....LP.VIV.................pVQVVKL....sIP.EAD....VGPHI-D...L.......KSSK..I.....RA--.PMTKEEYEKQQSTLKWITDPETGTKR..LIRGSGEIV.....EEMASKERPHSVKP............................TpSTlfAADGNFFQPQ---tnm..........
F1RFJ6_PIG/7-236                     ..............................................................RKRSRSRSRSR........-GRGSEKKRKKS....SKDA.P.RSCSA..S......RSQSRKAS.TTSSGAEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKK-.......-RKKKLK.KRSK....E.--KAKV.....QQ..AEA.....LP.GPS..................LDQWHR.....AA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
A0A093BP95_CHAPE/7-244               ..........................................................rkreRSRSKSRSGSR........-QDRREKKRRKS....SKDS.A.PGSSS..P......PRKEPSGS.HRHKSSS........AAG--KDK.KKRK..TST....SSS.ETQS..SS.T...S.SSSS....SS..SSSSSDDssd..................sdsKTK.KSRHsKK..K..RVKQKDKK.......KKKKRIK.KKSKk.lkE.RAKEEK.....AK..EEV.....MP.GPS..................LEQWQK.....ES.LVD....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEIL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQARTGM.............
I3MFE9_SPETR/7-227                   ..............................................................RKRSRSRSRSR........-GRRSEKRRKKS....SRDA.S.RSCSV..S......GSQGRKAS.TASG-SE........ERSKQKAR.RRPR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKR-.......--KKKLK.RRRK....E.--KAEV.....PQ..AEA.....PP.GPS..................LDQWHR.....ST.GEE...dDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
AR6P4_RAT/7-229                      ..............................................................RKRSRSRSRSR........GRRGSEKRSKRS....SKDS.S.RNCST..S......KSQGHKAS.STSGVE-........ERSKHKAQ.RTSR..--S....SSS.SSSS..SS.S...S.SSSS....TS..SSSSSDG........................RKK.RGKH.KD..K..KKRKKKK-.......KRKKKMK.RKGK....E.-KAVVV.....HQ..AEA.....LP.GPS..................LDQWHR.....SA.GED...nDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
D3Z6F1_MOUSE/34-226                  ..........................................plggslpleqgtkalpspci-----------........------------....----.-.-----..-......--------.------T........ERSKHKAQ.RTSR..---....-SS.STSS..SS.S...-.SSSS....AS..SSSSSDG........................RKK.RAKH.KE..K..KRKKKKK-.......KRKKKLK.KRVK....E.-KAVAV.....HQ..AEA.....LP.GPS..................LDQWHR.....SA.GED...nDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRTGL.............
U3I250_ANAPL/86-202                  ...........................................................sep-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.KAKK....S.RHKEES.....TK..AEV.....VP.GPS..................LEQWQK.....ES.LVD....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.AT..RGDGLAFQVRTGM.............
A0A0C4DH18_HUMAN/7-124               ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQGRKAS.TAP-GAE........ERSKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.KAEA--.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....----.--------------------------..---------.....--------------............................-.--..-------------q............
G3WL28_SARHA/36-275                  ...........................................................shkRSRSRSRSGSHg......pPEHGERRRRRRS....SKDM.G.RSPSA..S......GSQGQRIS.LGSNGE-........ERSRDKAR.KRRR..PRS....SSS.SSSS..SS.S...S.SSSS....ST..SSSSSSGas...................sggRKK.RGKR.KD..K..KSTKKKAKkk...lrKKKKKKK.KKEE....K.AAKAKA.....KA..VEE.....MP.GPS..................LDQWRK.....EP.PVE....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHKEINK............................Q.AT..RGDGLTFQLRAGL.............
V4BEC1_LOTGI/1-67                    .............................................................l-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....---K.PMTKEEWEKQQSIVRKVYDPETGRHR..LIKGDGEVI.....EEIVSKERHKEINK............................T.AT..KGDGLYYQTQAGL.............
F6TAV8_ORNAN/7-235                   ............................................................rrRSRSRSGSRGR........PERSKEMRRKRG....SKER.R.RSRSA..S......GSRSRRPR.AASH-KP........ERSKDRGR.KRRR..PSS....SSS.STSS..SS.S...S.SSSS....SS..SSRSSSG.......................gRKK.RSKR.KD..K..KRRKKKKK.......KAKKKVK.KKCR....E.KGEAGT.....QS..PQG.....MP.GPS..................LDQWQK.....EP.LEE....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVVRKVVDPETGRTR..LIKGDGEIL.....EEIVTKERHKEINK............................Q.AT..RGDGLAFQLRAGL.............
F5H7X4_HUMAN/130-307                 ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......TSQASPSP.CI----T........ERSKQKAR.RRTR..SSS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKGK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRT-..---------.....--------------............................-.--..-------------.............
F6S524_XENTR/7-224                   ............................................................kkRSRSRSPKVSQ........-SKSSKKKKKLS....SRCR.-.---SS..S......DSPVRKHS.TLAKYRAev....pdRRKKERRK.KKRR..RTV....STT.SSSS..SS.S...E.SSSS....SS..SSCSSSD........................DSV.DSSC.KS..K..KSSHTSF-.......------K.---L....E.CQDAKG.....TA..KEV.....LP.GPS..................INPCQK.....ES.PED....TGPALTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRMR..LIKGDGEVL.....EEIVSKERHKEINK............................Q.ST..QKDGLAFQMHSGM.............
H3BE34_LATCH/3-242                   ..............................................................RSRSRERSRSRtktsscgkGLKRDGKKRSRS....SSSS.R.RSTSL..S......KKCHHSTS.PSK----........ERKPEKKK.AKRK..PSA....STS.SDSS..SP.A...S.STST....CS..SSLSDSDtes..................kesKQQ.KGKN.KT..K..KSKKKSKKm....nrKSKKMKK.KKAK....E.APTAAK.....PK..LSK.....MA.GPS..................VEQWQR.....ET.WVE....SGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETRRTR..LVKGDGEIL.....EEIVSRERHKEINR............................Q.AT..VGDGVSFQTRMGL.............
F6VBC1_HORSE/7-229                   ..............................................................RKGSRSRSGTR........-ERGSEKRRKKS....SKDA.P.RSCSA..S......RSQGRKAS.TVSPGAE........AQRRSKHK.ARRR..PRS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKH.KD..K..KRKKKKK-.......-RKKRLK.KKGK....E.--KAKV.....QQ..AEA.....LP.GPS..................LDQWHR.....AA.EEE...eHGPVLTD...E.......QKTR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQLRAGL.............
G3P006_GASAC/2-241                   ............................................................dr-----RRSIERg.....grEKKLEKKKRRRS....SSSS.S.SSSSS..S......-SSSRSRS.RSSKKTP........NKSQDVKT.QRKK..RRR....SSS.SSSS..TS.S...S.SSSS....TS..DEKTKKKk......................sKAK.KKKL.KK..M..KAKLKKQK.......KKEKREK.KKKE....KlKKKEEK.....KK..AEVv...lLP.-PSppve.........kppsyLEVWQS.....DEgAVE....LGPVMTD...E.......QKAR..L.....ATKR.PITKEEYEARQSVIRRVVCPETGRTR..LVRGEGEII.....EEIVSREKHKDINK............................Q.AT..KGDGKEFQRKLGV.............
E2BI88_HARSA/1-124                   ............................................................mq-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..-KRKKKKK.......RMRKKLK.KKSK....K.IVPKKK.....RH..SKK.....KP.---..................---KEK.....TG.KED....TTNEIAS...E.......MAEK..A.....KAMA.PMTKEEWEKRQSIVRKVYDKETGRYR..LIKGDGEVL.....EEIVSRDHHREINR............................Q.AT..KGDGEYFQARL--km...........
A7USQ6_ANOGA/1-202                   .........................................................mkdsr-----------........------------....----.-.-----..-......--------.-------........--KRRKS-.--RR..DST....SSS.SSS-..-S.R...D.SSAS....ST..SGTSDSDssstss...........ssrsssvERK.RRKK.EL..K..KKLAKQQKk....eaKAKKKAL.RKEK....K.ARRKQE.....KL..ESK.....LA.KRK..................LKEERKsrrkqEK.HSK....DGDIPNS...N.......CGIP..LdlmnrKAMA.PETREEYEARQSILRRVVDPETGRTR..LIKGDGEII.....EECVSRDRHKEINR............................Q.AT..AGDGAEFQRKT--lg...........
B4HGH6_DROSE/1-137                   ...........................................................mgk-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-----SE........................KKS.KKKH.KE..K..RREHKEK-.......HKSKKSK.KHSR....K.---KEE.....SP..PIA.....SP.SPI.................qPERVNQ.....EE.EDD...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRKEVDPVTGRVR..LIKGDSEVL.....EEIVTKERHLEINK............................K.AT..RGDGEFYETR---sl...........
L5KS64_PTEAL/7-220                   ..............................................................RKRSRSRSRSR........-GRGSEKRRKKS....SKDA.T.KSCSA..S......RSQGRKAS.TTTSGAE........ERSKHKAR.RRPR..SSS....SSS.SPS-..SS.S...S.SSSS....AS..SSSSSDG........................RKK.RGKH.KD..K..KKKLQRW-.......--KKKLK.KKDK....E.--KTKA.....QQ..PEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................V.--..-------------gvtslpra.....
T1GW67_MEGSC/81-149                  ..........................................................gvra-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......----..-.....----.PEKPEEYAARQSKIRRVKDEETGRMR..LIKGDGEVL.....EEIVSKQRHQEINK............................Q.AT..KGDGEYFKSKT--tg...........
B4G424_DROPE/1-134                   ..........................................................mgks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..------E........................KKS.KKKH.KE..K..RKEHKEK-.......HKSRKSK.KHTK....Q.--KDAT.....PP..PQA.....PP.PPP..................PPDISS.....--.DED...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRREVDPVTGRIR..LIKGDSEVL.....EEIVSKERHTDINK............................K.AT..RGDGEYYESR---s............
W4YHG3_STRPU/421-671                 ...............................................krrspsssddeldgr-----KGERSE........KRLDSERKPEKS....RKEG.S.KNKPG..S......GKNGKDTK.KLK----........DKKPEKKA.RKRK..ASW....SSG.SDLS..ES.D...I.SLHS....TP..AKKAKDKkdrtvk...........skkahmkDKK.KKKH.KK..E..HRKEKKQKdi...lrKKSKEKK.KKATr.kqE.EGSKKK.....KT..DEV.....VP.LSGiq..............kkLIEMAK.....-A.GKK....EEP---S...E.......EGSS..K.....RSMV.PMTKEQYDKEESKVRRVYDADTGRNR..LIRGSGEVL.....EEIVSRDRHKEINK............................A.AT..KHDGIAYSK----si...........
F4WVX6_ACREC/74-246                  ...........................................................sss-----------........------------....----.-.-----..-......--------.-------........--------.----..NSS....SSS.SSSS..SD.T...N.SSNS....GS..SIDSSEDe......................kKQK.KARK.KA..K..KFKKALKK......rKKKKRMK.KKLK....K.KFKKSVskkkgHN..KKK.....SK.GNK..................EVQDRK.....EK.MKE....----IVS...N.......VIER..G.....KAMA.PMTKEEWEKRQSIVRRVYDEETGRHR..LIKGDGEVL.....EEIVSRERHKEINK............................Q.AT..KGDGKYFQTHL--km...........
H0XEC0_OTOGA/59-266                  ..............................................................RKRSRSRSRSR........-GRGSEKRRKNS....SRDA.S.RSCSA..S......GSQE----.-------........-RSKHKAR.RRPR..--S....SSS.SSSS..SS.S...S.SSSS....SS..SPSSSDG........................RKK.HGKH.KD..K..KRKKKKK-.......--KKKLK.KKGK....E.--KTEA.....QQ..AEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LMVEAGKAE.....PTLVSSSRHREINK............................Q.AT..RGDGLAFQMRAGL.............
F6XIW1_CALJA/7-234                   ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDT.S.RNCSA..S......ESQGCKGS.AALGAEG........EDHRHCWA.GRPG..SRE....GTP.LGSS..IS.A...L.ESPA....GG..AHPVDGLtqa..................ragDEE.RSKH.KA..R..RP------.......-RSSGRK.KRGK....H.--RAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..-RSGAGAGLlllekSQVLAKRHHREINK............................Q.AT..RGDGLAFQMRAGL.............
A0A067QJQ7_ZOONE/1-194               ...............................................madkkrshgsslesq-----------........------------....----.-.-----..-......--------.-------........SLSPDRTR.ICKI..SEA....SSE.QNEL..SK.KlrlK.ENSR....SS..NLPKEKE........................KKK.KLKK.LE..K..KKRMKEKKl.....kKKHKKEK.RRLK....K.AAAAAM.....TS..TEN.....AK.DVK..................HKVFRD.....KE.PEE...pSDQLLMD...-.......---R..A.....KAMA.PMTKEEWEKRQSVIRKVYDEETGRHR..LIKGDGEIL.....EEIVSRDRHREINR............................Q.AT..QGDGAFFQS----tia..........
E2A8S0_CAMFO/132-444                 nsrpyrrqnyydrnrrdtynnyynrhnnrnyertssygrsrlqdyykstgrnatsqsvreds-------SKERm.....nqSRATLMTESLDS....IKDN.T.EIIEQ..A......KEREKKKG.ISRD-KS........QPSRKKLK.RKRSlsTSS....SSSiSSSS..SS.S...SnSSSS....SS..SSSS--SssggggditgsssssstdssederKQK.KAKK.KA..K..KLKKAMKK.......RKKKRMK.KKLK....K.KLKKST.....SK..KKGh..skKK.SKE..................NKEIQG.....SG.KRE....STKEVVP...E.......VMEK..A.....KAMA.PMTKEEWEKRQNMIRRIYDQETGRYR..LIKGDGEVL.....EEIVSRDRHKEINK............................Q.AT..KGDGEYFQAHL--km...........
H2Q752_PANTR/130-358                 ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDA.S.RNCSA..S......TSQGRKAS.TAPGAEAsps.pcitERSKQKAR.RRPR..SSS....SSS.SSSS..PS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RRKKKKK-.......--RKKLK.KKSK....E.--KAEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
H0W757_CAVPO/66-182                  ..........................................................ssdg-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-----RK.KRGK....-.-HKAGV.....QP..AEA.....LP.GPS..................LEQWHQ.....SA.WEE...dNGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRRVVDPETGRTR..--WGALGTT.....RPIACHERHREINK............................Q.AT..RGDGLSFQIRAGL.............
A0A087ZPZ8_APIME/259-417             ............................................................sd-----------........------------....----.-.-----..-......--------.-------........--------.----..--S....SSS.SSSS..SS.T...S.SSCS....SS..SSDTSEDe......................kKRK.KARR.KA..K..KLKKAMKK......rRKKKRMK.KKLK....K.KLKKSK.....KK..LRN.....--.---..................TDKSKE.....SI.SKD....----VSQ...E.......ISEK..S.....KAMA.PMTKEEWEKKQNVIRKVYDEETGRYR..LIKGDGEVI.....EEIVSRERHKEINK............................Q.AT..KGDGEYFQARL--k............
D3YWC2_MOUSE/4-198                   ...........................................................vgs-----------........------------....----.-.RKRSR..S......RSRSRSGR.RGSEKR-........KRSKHKAQ.RTSR..---....-SS.STSS..SS.-...S.SSSS....AS..SSSSSDG........................RKK.RAKH.KE..K..KRKKKKK-.......KRKKKLK.KRVK....E.-KAVAV.....HQ..AEA.....LP.GPS..................LDQWHR.....SA.GED...nDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRTGL.............
A0A0D9S520_CHLSB/130-350             ..............................................................RKRSRSRSRSR........-GRGSEKRKKKS....RKDA.S.-----..-......ASQGRKAS.TALGAEAsps.pcitERSKHKAR.RRPR..-SS....SSS.SSSS..SS.S...S.SSSS....SS..SSSSSDG........................RKK.RGKY.KD..K..RKKKKKR-.......---KKLK.KKGK....E.--KVEA.....QQ..VEA.....LP.GPS..................LDQWHR.....SA.GEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
D6WEC8_TRICA/89-164                  .........................................................pvelm-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.----....-.------.....--..---.....--.---..................------.....--.---....-------...-.......--AK..S.....KAMA.PMTKEQWEKQQSVVRRVYDETTGRHR..LIKGDGEVI.....EEIVSRDRHKAINQ............................Q.AT..RGDGEFFQAQ---mf...........
G3SW00_LOXAF/68-184                  ............................................................dg-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-------........................---.----.--..-..--------.......-------.RKKR....R.KHKAKV.....QQ..AEA.....LP.GPS..................LDQWHR.....AA.AEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSVIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
Q298K4_DROPS/1-134                   ..........................................................mgks-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..------E........................KKS.KKKH.KE..K..RKEHKEK-.......HKSRKSK.KHTK....Q.--KDAT.....PP..PQA.....PP.PPP..................PPDISS.....--.DED...fAIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRREVDPVTGRIR..LIKGDSEVL.....EEIVSKERHTDINK............................K.AT..RGDGEYYESR---s............
J9P4L0_CANFA/50-281                  ..............................................................RKRSKSRSRSR........-GRGSEKRRKKS....SKDA.P.RSCSA..S......RCQDRKAI.ITSSGAEaspspcitERSKHKAR.RRPR..-SS....SSS.SSSG..SS.S...S.SSSS....SS..SSSSSGD........................RKK.RGKH.KD..K..KRRKKKR-.......KRKKQLK.KKGK....E.KA-KLQ.....QQ..GEA.....LP.GPS..................LDQWHR.....SA.EEE...eDGPVLTD...E.......QKSR..I.....QAMK.PMTKEEWDARQSIIRKVVDPETGRTR..LIKGDGEVL.....EEIVTKERHREINK............................Q.AT..RGDGLAFQMRAGL.............
B3LWY8_DROAN/1-137                   ...........................................................mgk-----------........------------....----.-.-----..-......--------.-------........--------.----..---....---.----..--.-...-.----....--..-----SD........................KKS.KKSH.KH..K..RREHKEK-.......HKSKKSK.KHSR....Q.----KQ.....GA..SPA.....IT.EPNi...............qkLEQEQE.....QE.EDF....SIPIALM...N.......SKSH..-.....---A.PETPEEYQRRQSQIRREVDPVTGRTR..LIKGDSEVL.....EEIVSKERHTEINK............................K.AT..RGDGEYYEQR---tl...........
#=GC seq_cons                        ................................................................................................................................................t.tptp.tp.+...ps....SSo.usSS..SS.s...s.SSSS....oS..spsSsss........................++K.+tKp.Kc..K..++++Kc+..........cKKhK.KKtK....c...Ktpt.....pp..scs.....lP.uPu..................l-phpp.....ps.tc-....sGPlhTD...E.......QKoR..l.....pAM+.PMTKEEW-ARQSlIR+VVDPETGRTR..LIKGDGEVL.....EEIVoKERH+EINK............................Q.AT..+GDGhtFQh+h...............
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