GenomeNet

Database: Pfam
Entry: STAT_int
LinkDB: STAT_int
Original site: STAT_int 
#=GF ID   STAT_int
#=GF AC   PF02865.16
#=GF DE   STAT protein, protein interaction domain
#=GF PI   STAT_prot; 
#=GF AU   Bateman A, Griffiths-Jones SR
#=GF SE   Pfam-B_856 (release 3.0)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.20;
#=GF NC   25.00 25.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   STAT_protein
#=GF RN   [1]
#=GF RM   9671298
#=GF RT   Three-dimensional structure of the Stat3beta homodimer bound to
#=GF RT   DNA. 
#=GF RA   Becker S, Groner B, Muller CW; 
#=GF RL   Nature 1998;394:145-151.
#=GF RN   [2]
#=GF RM   9461439
#=GF RT   Structure of the amino-terminal protein interaction domain of
#=GF RT   STAT-4. 
#=GF RA   Vinkemeier U, Moarefi I, Darnell JE Jr, Kuriyan J; 
#=GF RL   Science 1998;279:1048-1052.
#=GF DR   INTERPRO; IPR013799;
#=GF DR   SCOP; 1bgf; fa;
#=GF CC   STAT proteins (Signal Transducers and Activators of
#=GF CC   Transcription) are a family of transcription factors that are
#=GF CC   specifically activated to regulate gene transcription when cells
#=GF CC   encounter cytokines and growth factors. STAT proteins also
#=GF CC   include an SH2 domain Pfam:PF00017.
#=GF SQ   604
#=GS M3ZIM3_XIPMA/2-120        AC M3ZIM3.1
#=GS M3YM88_MUSPF/81-199       AC M3YM88.1
#=GS A0A0Q9WFD3_DROVI/5-120    AC A0A0Q9WFD3.1
#=GS B0JYL6_BOVIN/2-120        AC B0JYL6.1
#=GS F1QUB5_DANRE/1-115        AC F1QUB5.2
#=GS A0A091QEC4_HALAL/2-120    AC A0A091QEC4.1
#=GS F6TGN6_HORSE/3-125        AC F6TGN6.1
#=GS H2Z5N2_CIOSA/72-215       AC H2Z5N2.1
#=GS A0A093IK63_FULGA/2-116    AC A0A093IK63.1
#=GS I3IXU2_ORENI/2-124        AC I3IXU2.1
#=GS M3WKY3_FELCA/2-114        AC M3WKY3.1
#=GS A0A087X3Z4_POEFO/2-120    AC A0A087X3Z4.2
#=GS A0A091RJ68_9GRUI/471-589  AC A0A091RJ68.1
#=GS F7I183_CALJA/2-120        AC F7I183.1
#=GS F6S2M5_CALJA/2-124        AC F6S2M5.1
#=GS STAT2_MOUSE/2-122         AC Q9WVL2.1
#=GS H2QD20_PANTR/2-120        AC H2QD20.1
#=GS M3YGI3_MUSPF/2-124        AC M3YGI3.1
#=GS F7EAF6_XENTR/5-114        AC F7EAF6.1
#=GS G1T0H3_RABIT/2-120        AC G1T0H3.2
#=GS M3WNM1_FELCA/2-120        AC M3WNM1.1
#=GS C3ZBA3_BRAFL/2-119        AC C3ZBA3.1
#=GS H2RJA8_TAKRU/2-120        AC H2RJA8.1
#=GS A0A0F8CPM0_LARCR/2-120    AC A0A0F8CPM0.1
#=GS M3VY00_FELCA/2-124        AC M3VY00.1
#=GS G3VBL4_SARHA/2-123        AC G3VBL4.1
#=GS A2A5D3_MOUSE/2-124        AC A2A5D3.1
#=GS H3DKH3_TETNG/2-121        AC H3DKH3.1
#=GS H0VXN9_CAVPO/3-125        AC H0VXN9.1
#=GS A0A0G2JX93_RAT/382-500    AC A0A0G2JX93.1
#=GS A0A091DCI0_FUKDA/33-151   AC A0A091DCI0.1
#=GS F4WR54_ACREC/2-124        AC F4WR54.1
#=GS M3ZBU4_NOMLE/2-120        AC M3ZBU4.1
#=GS M4A840_XIPMA/2-119        AC M4A840.1
#=GS F6TWL1_XENTR/2-121        AC F6TWL1.1
#=GS H2ZMV3_CIOSA/4-127        AC H2ZMV3.1
#=GS STAT4_HUMAN/2-120         AC Q14765.1
#=GS F6XAW1_CANLF/2-123        AC F6XAW1.1
#=GS A0A087XMD8_POEFO/2-120    AC A0A087XMD8.2
#=GS G1S6J6_NOMLE/2-114        AC G1S6J6.1
#=GS F6Q0N5_XENTR/471-589      AC F6Q0N5.1
#=GS S7N9C3_MYOBR/2-124        AC S7N9C3.1
#=GS T1HR32_RHOPR/2-125        AC T1HR32.1
#=GS G3P1B5_GASAC/2-120        AC G3P1B5.1
#=GS I3IXW4_ORENI/2-120        AC I3IXW4.1
#=GS G3VVX3_SARHA/2-114        AC G3VVX3.1
#=GS G3SX92_LOXAF/2-114        AC G3SX92.1
#=GS J3KPM9_HUMAN/4-122        AC J3KPM9.1
#=GS K7EK35_HUMAN/2-124        AC K7EK35.1
#=GS A0A0D9RIE1_CHLSB/2-120    AC A0A0D9RIE1.1
#=GS M3WSW7_FELCA/2-120        AC M3WSW7.1
#=GS L9JWK9_TUPCH/2-124        AC L9JWK9.1
#=GS H2MK17_ORYLA/1-74         AC H2MK17.1
#=GS G3TCH4_LOXAF/2-124        AC G3TCH4.1
#=GS F6U1D9_HORSE/2-123        AC F6U1D9.1
#=GS A0A096MQY8_PAPAN/2-120    AC A0A096MQY8.1
#=GS B4K7R7_DROMO/5-120        AC B4K7R7.2
#=GS K7IWW4_NASVI/2-125        AC K7IWW4.1
#=GS B7PKW7_IXOSC/2-121        AC B7PKW7.1
#=GS A0A067RHS1_ZOONE/2-123    AC A0A067RHS1.1
#=GS F6ZP14_HORSE/2-124        AC F6ZP14.1
#=GS H3DCB5_TETNG/2-121        AC H3DCB5.1
#=GS A0A087XZL1_POEFO/2-120    AC A0A087XZL1.2
#=GS G7PUU5_MACFA/2-124        AC G7PUU5.1
#=GS M3WG72_FELCA/2-123        AC M3WG72.1
#=GS L5KVS4_PTEAL/2-114        AC L5KVS4.1
#=GS K7FUH4_PELSI/2-120        AC K7FUH4.1
#=GS F2U6J4_SALR5/2-120        AC F2U6J4.1
#=GS G3TCH9_LOXAF/2-104        AC G3TCH9.1
#=GS I3K2L6_ORENI/2-120        AC I3K2L6.1
#=GS B7ZC18_MOUSE/2-100        AC B7ZC18.1
#=GS L9KVU3_TUPCH/560-678      AC L9KVU3.1
#=GS A0A091JXJ7_COLST/2-97     AC A0A091JXJ7.1
#=GS W5MUZ4_LEPOC/465-583      AC W5MUZ4.1
#=GS G5BB56_HETGA/2-114        AC G5BB56.1
#=GS D6WML4_TRICA/2-126        AC D6WML4.1
#=GS F6UJK9_XENTR/2-120        AC F6UJK9.1
#=GS A0A0J7NU89_LASNI/374-457  AC A0A0J7NU89.1
#=GS H9IWV6_BOMMO/2-118        AC H9IWV6.1
#=GS A0A091GS37_BUCRH/2-120    AC A0A091GS37.1
#=GS H2LGJ1_ORYLA/2-120        AC H2LGJ1.1
#=GS B3DGV1_DANRE/2-121        AC B3DGV1.1
#=GS A0A0T6B5L0_9SCAR/2-126    AC A0A0T6B5L0.1
#=GS G3VMK1_SARHA/2-124        AC G3VMK1.1
#=GS Q4V9B2_DANRE/2-124        AC Q4V9B2.1
#=GS W5L336_ASTMX/2-122        AC W5L336.1
#=GS Q99K94_MOUSE/2-120        AC Q99K94.1
#=GS A0A091E5Z6_CORBR/2-120    AC A0A091E5Z6.1
#=GS A0A096NH08_PAPAN/2-123    AC A0A096NH08.1
#=GS M7B1U4_CHEMY/2-110        AC M7B1U4.1
#=GS G3WWX6_SARHA/2-120        AC G3WWX6.1
#=GS F1SN34_PIG/2-120          AC F1SN34.2
#=GS A0A091DBS0_FUKDA/2-124    AC A0A091DBS0.1
#=GS I3K2L5_ORENI/2-120        AC I3K2L5.1
#=GS STAT3_HUMAN/2-120         AC P40763.2
#=GS A0A087VEB0_BALRE/1-109    AC A0A087VEB0.1
#=GS Q4H2R0_CIOIN/2-125        AC Q4H2R0.1
#=GS A0A0P7Z2V0_9TELE/144-259  AC A0A0P7Z2V0.1
#=GS F7AIL6_MACMU/2-120        AC F7AIL6.1
#=GS H2U8H0_TAKRU/2-120        AC H2U8H0.1
#=GS G3HRN9_CRIGR/2-121        AC G3HRN9.1
#=GS O93378_CHICK/2-124        AC O93378.1
#=GS G3SD14_GORGO/2-114        AC G3SD14.1
#=GS A0A151PC08_ALLMI/80-198   AC A0A151PC08.1
#=GS A0A087Y4L9_POEFO/2-120    AC A0A087Y4L9.2
#=GS U3JC79_FICAL/2-114        AC U3JC79.1
#=GS A0A093PX68_9PASS/2-120    AC A0A093PX68.1
#=GS G5BB74_HETGA/2-123        AC G5BB74.1
#=GS Q9QXJ2_MOUSE/2-122        AC Q9QXJ2.1
#=GS G1SHL8_RABIT/2-120        AC G1SHL8.1
#=GS H2LGI9_ORYLA/2-120        AC H2LGI9.1
#=GS G3NDX8_GASAC/2-117        AC G3NDX8.1
#=GS A0A096P5S7_PAPAN/2-124    AC A0A096P5S7.1
#=GS STAT6_MOUSE/2-114         AC P52633.2
#=GS G1R4S6_NOMLE/2-120        AC G1R4S6.1
#=GS I1G2N7_AMPQE/2-122        AC I1G2N7.1
#=GS Q6P943_DANRE/2-122        AC Q6P943.1
#=GS M3ZCB3_NOMLE/2-120        AC M3ZCB3.1
#=GS L5LNR3_MYODS/2-120        AC L5LNR3.1
#=GS W5QCC1_SHEEP/3-125        AC W5QCC1.1
#=GS E9PBE2_HUMAN/2-79         AC E9PBE2.1
#=GS F1MER9_BOVIN/2-124        AC F1MER9.2
#=GS H2NU10_PONAB/2-124        AC H2NU10.2
#=GS H0WM02_OTOGA/2-120        AC H0WM02.1
#=GS E2BNI6_HARSA/2-123        AC E2BNI6.1
#=GS E0VNH9_PEDHC/42-164       AC E0VNH9.1
#=GS F6WE02_MACMU/2-120        AC F6WE02.1
#=GS A0A0Q3PR11_AMAAE/627-745  AC A0A0Q3PR11.1
#=GS B4NFX0_DROWI/2-118        AC B4NFX0.2
#=GS A4IFU4_BOVIN/2-120        AC A4IFU4.1
#=GS B4IIB7_DROSE/2-118        AC B4IIB7.1
#=GS H9H8T9_MONDO/2-114        AC H9H8T9.2
#=GS F7CW94_MONDO/2-120        AC F7CW94.1
#=GS Q4SV14_TETNG/2-50         AC Q4SV14.1
#=GS W5J1W2_ANODA/2-126        AC W5J1W2.1
#=GS A0A094L142_9AVES/2-120    AC A0A094L142.1
#=GS M3VY01_FELCA/2-120        AC M3VY01.1
#=GS G3RVS4_GORGO/3-125        AC G3RVS4.1
#=GS A0A0P7UX82_9TELE/2-120    AC A0A0P7UX82.1
#=GS A0A0A0A6I3_CHAVO/2-116    AC A0A0A0A6I3.1
#=GS A0A0N0PAA1_PAPXU/2-118    AC A0A0N0PAA1.1
#=GS G3PSI5_GASAC/2-120        AC G3PSI5.1
#=GS H2ZMV4_CIOSA/2-125        AC H2ZMV4.1
#=GS A0A0L0DUL2_THETB/5-125    AC A0A0L0DUL2.1
#=GS G3V5I8_HUMAN/2-68         AC G3V5I8.1
#=GS STAT1_HUMAN/2-120         AC P42224.2
#=GS STAT1_HUMAN/2-120         DR PDB; 1YVL A; 2-120;
#=GS STAT1_HUMAN/2-120         DR PDB; 3WWT A; 2-120;
#=GS STAT1_HUMAN/2-120         DR PDB; 1YVL B; 1002-1120;
#=GS STAT1_PIG/2-120           AC Q764M5.1
#=GS G1P7M3_MYOLU/2-114        AC G1P7M3.1
#=GS A0A091DP11_FUKDA/2-114    AC A0A091DP11.1
#=GS S9X4C0_CAMFR/2-124        AC S9X4C0.1
#=GS G3SNM0_LOXAF/2-120        AC G3SNM0.1
#=GS S7PL51_MYOBR/728-846      AC S7PL51.1
#=GS A0A093IWQ1_FULGA/2-120    AC A0A093IWQ1.1
#=GS H2L389_ORYLA/2-120        AC H2L389.1
#=GS A0A0B4KHS7_DROME/2-118    AC A0A0B4KHS7.1
#=GS A0A0P7VEW1_9TELE/1-105    AC A0A0P7VEW1.1
#=GS STA5B_PIG/2-124           AC Q9TUZ0.1
#=GS A0A140T878_BOVIN/2-124    AC A0A140T878.1
#=GS F7BYN4_MONDO/36-154       AC F7BYN4.2
#=GS L8Y2S2_TUPCH/2-114        AC L8Y2S2.1
#=GS A0A0L0CLQ1_LUCCU/69-183   AC A0A0L0CLQ1.1
#=GS L5JPZ7_PTEAL/2-120        AC L5JPZ7.1
#=GS L5JRV5_PTEAL/2-124        AC L5JRV5.1
#=GS T1EM34_HELRO/2-123        AC T1EM34.1
#=GS H3BID4_LATCH/2-121        AC H3BID4.2
#=GS E2RE22_CANLF/2-124        AC E2RE22.2
#=GS G3N6I8_GASAC/2-120        AC G3N6I8.1
#=GS STAT2_HUMAN/2-123         AC P52630.1
#=GS B5DVV3_DROPS/2-118        AC B5DVV3.3
#=GS A0A1B8Y5M4_XENTR/2-124    AC A0A1B8Y5M4.1
#=GS Q7QEQ3_ANOGA/2-126        AC Q7QEQ3.3
#=GS W5N463_LEPOC/2-120        AC W5N463.1
#=GS H3DQY3_TETNG/1-45         AC H3DQY3.1
#=GS E4X335_OIKDI/11-133       AC E4X335.1
#=GS A0A091THK7_PHALP/2-120    AC A0A091THK7.1
#=GS G7PUU7_MACFA/2-120        AC G7PUU7.1
#=GS G3NDV7_GASAC/2-119        AC G3NDV7.1
#=GS H2Y2A7_CIOIN/85-228       AC H2Y2A7.1
#=GS W5NTT2_SHEEP/57-175       AC W5NTT2.1
#=GS G3V319_HUMAN/2-49         AC G3V319.1
#=GS A0A0D9RI15_CHLSB/2-120    AC A0A0D9RI15.1
#=GS A0A091UU98_NIPNI/2-120    AC A0A091UU98.1
#=GS A0A151P607_ALLMI/38-157   AC A0A151P607.1
#=GS A0A0D9S217_CHLSB/2-124    AC A0A0D9S217.1
#=GS U3JD42_FICAL/2-120        AC U3JD42.1
#=GS A0A0R3NHH1_DROPS/2-118    AC A0A0R3NHH1.1
#=GS H9KVZ1_CALJA/2-123        AC H9KVZ1.1
#=GS T0M5Y9_CAMFR/74-195       AC T0M5Y9.1
#=GS A0A0M9A970_9HYME/2-124    AC A0A0M9A970.1
#=GS Q66HB2_RAT/2-120          AC Q66HB2.1
#=GS H2P856_PONAB/2-120        AC H2P856.1
#=GS F7D2D3_MONDO/14-136       AC F7D2D3.2
#=GS A0A088AEX7_APIME/2-124    AC A0A088AEX7.1
#=GS G1PF83_MYOLU/469-587      AC G1PF83.1
#=GS STAT6_HUMAN/2-114         AC P42226.1
#=GS A0A0L0D4K5_THETB/6-133    AC A0A0L0D4K5.1
#=GS B3RME3_TRIAD/2-74         AC B3RME3.1
#=GS A0A094KHW2_9AVES/2-120    AC A0A094KHW2.1
#=GS STA5B_HUMAN/2-124         AC P51692.2
#=GS STA5A_RAT/2-124           AC Q62771.1
#=GS I3LI61_PIG/2-120          AC I3LI61.1
#=GS G3TZH2_LOXAF/2-108        AC G3TZH2.1
#=GS I3L6K8_PIG/2-114          AC I3L6K8.1
#=GS G5BGK4_HETGA/2-120        AC G5BGK4.1
#=GS F1RWH0_PIG/2-124          AC F1RWH0.3
#=GS W5KAS9_ASTMX/2-124        AC W5KAS9.1
#=GS A0A0D9S221_CHLSB/2-124    AC A0A0D9S221.1
#=GS G1NSF6_MYOLU/2-120        AC G1NSF6.1
#=GS F7BWA2_CHICK/28-146       AC F7BWA2.1
#=GS F7AEG1_CALJA/2-120        AC F7AEG1.1
#=GS STAT3_MOUSE/2-120         AC P42227.2
#=GS STAT3_MOUSE/2-120         DR PDB; 4ZIA C; 3-115;
#=GS STAT3_MOUSE/2-120         DR PDB; 4ZIA B; 3-120;
#=GS STAT3_MOUSE/2-120         DR PDB; 4ZIA E; 3-120;
#=GS STAT3_MOUSE/2-120         DR PDB; 4ZIA A; 3-120;
#=GS STAT3_MOUSE/2-120         DR PDB; 4ZIA D; 3-120;
#=GS A0A093DNE3_9AVES/2-120    AC A0A093DNE3.1
#=GS H2ZZY6_LATCH/2-123        AC H2ZZY6.1
#=GS G1KF84_ANOCA/517-635      AC G1KF84.2
#=GS M4A3I3_XIPMA/2-120        AC M4A3I3.1
#=GS H0WR40_OTOGA/2-114        AC H0WR40.1
#=GS G3VBL5_SARHA/2-123        AC G3VBL5.1
#=GS G7PIH9_MACFA/2-123        AC G7PIH9.1
#=GS STA5B_RAT/2-124           AC P52632.1
#=GS K7FUG0_PELSI/521-639      AC K7FUG0.1
#=GS F1SN37_PIG/2-120          AC F1SN37.2
#=GS A0A0L8ICI5_OCTBM/2-124    AC A0A0L8ICI5.1
#=GS A0A087XYL8_POEFO/2-124    AC A0A087XYL8.2
#=GS W5L337_ASTMX/2-122        AC W5L337.1
#=GS F6T2X3_XENTR/2-124        AC F6T2X3.1
#=GS S9X1S2_CAMFR/2-124        AC S9X1S2.1
#=GS A0A087WSP5_MOUSE/2-120    AC A0A087WSP5.1
#=GS L5JQ54_PTEAL/2-124        AC L5JQ54.1
#=GS G5BGK5_HETGA/2-120        AC G5BGK5.1
#=GS M4AJB2_XIPMA/2-124        AC M4AJB2.1
#=GS E7ENM1_HUMAN/2-120        AC E7ENM1.1
#=GS M3WPX1_FELCA/2-123        AC M3WPX1.1
#=GS A0A091L9I9_CATAU/2-100    AC A0A091L9I9.1
#=GS Q68SP3_DANRE/2-124        AC Q68SP3.1
#=GS G3V568_HUMAN/2-114        AC G3V568.1
#=GS E2AP84_CAMFO/2-124        AC E2AP84.1
#=GS F1NHP9_CHICK/2-120        AC F1NHP9.2
#=GS E9PG69_HUMAN/2-112        AC E9PG69.1
#=GS STA5A_PIG/2-124           AC Q9TUZ1.1
#=GS G3UQY3_MELGA/2-120        AC G3UQY3.1
#=GS G3P0T6_GASAC/2-105        AC G3P0T6.1
#=GS H2L880_ORYLA/2-120        AC H2L880.1
#=GS A0A0B4KGE1_DROME/2-118    AC A0A0B4KGE1.1
#=GS G1LHK6_AILME/2-124        AC G1LHK6.1
#=GS A2A5D4_MOUSE/2-51         AC A2A5D4.1
#=GS G3QYU4_GORGO/2-126        AC G3QYU4.1
#=GS M3YGH5_MUSPF/2-120        AC M3YGH5.1
#=GS I1G2N6_AMPQE/2-122        AC I1G2N6.1
#=GS K7FU55_PELSI/2-120        AC K7FU55.1
#=GS H0VKX1_CAVPO/2-124        AC H0VKX1.1
#=GS S7N8R2_MYOBR/31-149       AC S7N8R2.1
#=GS G3V5K5_HUMAN/2-114        AC G3V5K5.1
#=GS L5K217_PTEAL/591-709      AC L5K217.1
#=GS A0A084VIZ0_ANOSI/2-126    AC A0A084VIZ0.1
#=GS A0A087WSQ5_MOUSE/2-120    AC A0A087WSQ5.1
#=GS W5MV00_LEPOC/2-120        AC W5MV00.1
#=GS F1QWX2_DANRE/2-124        AC F1QWX2.1
#=GS A0A0P7WQK5_9TELE/413-531  AC A0A0P7WQK5.1
#=GS S7PXD0_MYOBR/44-156       AC S7PXD0.1
#=GS A0A0N1ID72_PAPMA/2-91     AC A0A0N1ID72.1
#=GS G3UU36_MELGA/2-120        AC G3UU36.1
#=GS G3RWV6_GORGO/2-123        AC G3RWV6.1
#=GS H2UQK9_TAKRU/2-120        AC H2UQK9.1
#=GS A0A151NB22_ALLMI/2-120    AC A0A151NB22.1
#=GS G3TCI8_LOXAF/2-120        AC G3TCI8.1
#=GS F6Z6Y4_HORSE/2-120        AC F6Z6Y4.1
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G1LID7_AILME/2-120                   ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
A0A096N8T7_PAPAN/2-120               ...................SQWNQVQQ...L...EI...KFLEQVDQFYDDN.FPM.E...IRHLLAQWIENQD...WEAAS..----.N.........NETMATILLQNL...L....IQLDEQLGRVS............KEK..NLLLIHNLKRIRKVL......QGKFHGN....PMHVAVVISNCLREERRILAAA-n............................
G1RLB0_NOMLE/70-188                  ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
C9JVV6_HUMAN/2-124                   ...................AGWIQAQQ...L...QG...DALRQMQVLYGQH.FPI.E...VRHYLAQWIESQP...WDAID..LDNP.Q.........DRAQATQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QKTYDRC....PLELVRCIRHILYNEQRLVREA-n............................
G3V370_HUMAN/2-114                   ...................SLWGLVSK...M...PP...---EKVQRLYVD-.FPQ.H...LRHLLGDWLESQP...WEFLV..----.G.........SDAFCCNLASAL...L....SDTVQHLQASV............GEQ..--GEGSTILQHISTL......ESIYQRD....PLKLVATFRQILQGEKKAVMEQ-f............................
G3PSI1_GASAC/2-120                   ...................AQWLQLQK...L...DS...KYLEQVDQLYDDS.FPM.D...IRQYLSRWIESID...WDTVA..----.V.........QDSLATVRFHDL...L....VQLDDQHSRFA............LEN..NFLLQHNIRKIRRNL......QDRFQED....PVHMAMIISRNLKEEKKILEK--vk...........................
V8P7D2_OPHHA/32-151                  ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVAPAVVTEKQQ-----mleqhl.......................
H0YWJ7_TAEGU/3-127                   ...................AVWIQAQQ...L...QG...EALRQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSID..LDNP.Q.........ENVKATQLLEGL...I....QELQKKADHQV............GED..GFLLKIKLGHYATQLq....aRNTYDRC....PMELVRCIRHILYHEQRLVREA-n............................
STAT3_CHICK/2-120                    ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.N.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
A0A096MHP7_POEFO/1-70                ..................s--------...-...--...-------------.---.-...-------------...-----..----.-.........---LATIRFHDL...L....AQLDDQHSRFA............LES..NFLQQHNFRKIKRNL......QDRFQED....PVTMAMIISRNLKEEQKILV---cak..........................
E1B8Z4_BOVIN/2-123                   ...................AQWEMLQN...L...DS...PFQDQLHELYSNSlLPM.D...VRQHLAVWIEDQN...WQKAA..--LG.N.........DAAMANMLFLHF...L....DQLNSECGRCS............QDS.eYFLLQHNLRKFYRDI......QA-LPTG....STQLAEMIFNLLLEEKRILTW--aq...........................
E2RI87_CANLF/467-585                 ...................SQWYELQQ...L...DS...KFLEQVHQLYDDC.FPM.E...IRQYLAQWLEKQD...WEHAA..----.N.........DVSFATIRFHDL...L....SQLDDQYSRFS............LEN..NFLLQHNIRKSKRNL......QDNFQED....PIQMSMIIYNCLKEERKILENA-q............................
STAT3_BOVIN/2-120                    ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQLLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
A0A0Q3URQ2_AMAAE/2-124               ...................AVWIQAQQ...L...QG...EALRQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSID..LDNP.Q.........ENVKATQLLEGL...I....QELQKKADHQV............GED..GFLLKIKLGHYATQL......QNTYDRC....PMELVRCIRHILYHEQRLVREA-n............................
C9J4I3_HUMAN/2-124                   ...................AVWIQAQQ...L...QG...EALHQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSVD..LDNP.Q.........ENIKATQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QNTYDRC....PMELVRCIRHILYNEQRLVREA-n............................
H2P855_PONAB/18-136                  ...................SQWYELQQ...L...DS...KFLEQVHQLYDDS.FPM.E...IRQYLAQWLEKQD...WEHAA..----.N.........DVSFATIRFHDL...L....SQLDDQYSRFS............LEN..NFLLQHNIRKSKRNL......QDNFQED....PIQMSMIIYSCLKEERKILENA-q............................
B3DLJ2_XENTR/2-121                   ...................SQWAAILK...L...ST...EFQEKVMALYSQElFPM.E...VRQYLASWIESQD...WKQAA..----.R.........DLSLANVQLQNL...L....EHLDIQYSRFA............QEQ..EILQQRNFRRFKCDI......QARYQAH....PQNLAEIIRDILLYEKQILSEA-r............................
G1RL09_NOMLE/2-113                   ...................AVWIQAQQ...L...QG...EALHQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSID..LDNP.Q.........ENIKATQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QVGYCSC....CLVLV------------------fffftfy......................
A0A091HNR2_CALAN/2-120               ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
A0A0Q9WFM5_DROVI/5-120               ...................SLWKRISS...-...HA...DCEQRMAAYYNKKgL-Y.D...LRLCLAPWIEDRI..mSEQIT..---P.N.........STNQLERVAIKF...I....EDLQQKLLSTR............AS-..DQVLKYRLVELCALI......QR---TP....ALELYTHLRSGLQKELQLAAEK-s............................
STAT4_MOUSE/2-120                    ...................SQWNQVQQ...L...EI...KFLEQVDQFYDDN.FPM.E...IRHLLAQWIETQD...WEVAS..----.N.........NETMATILLQNL...L....IQLDEQLGRVS............KEK..NLLLIHNLKRIRKVL......QGKFHGN....PMHVAVVISNCLREERRILAAA-n............................
#=GR STAT4_MOUSE/2-120         SS    ...................-HHHHHHH...S...-G...GGHHHHGGG-BTT.B-H.H...HHHHTHHHHHHS-...HHHHT..----.T.........-HHHHHHHHHHH...H....HHHHHHHHHHH............HHT..-HHHHHHHHHHHHHH......HHHHHS-....HHHHHHHHHHHHHHHHHHHHHS--............................
G3RLN8_GORGO/2-114                   ...................AGWIQAQQ...L...QG...DALRQMQVLYGQH.FPI.E...VRHYLAQWIESQP...WDAID..LDNP.Q.........DRAQATQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QC-----....-----------------------sspagilvdamsqkhlqi...........
H2TTP2_TAKRU/2-117                   ...................SQWKQIQN...L...EI...RLLEHVDYLYDDN.FPM.D...IRQVLASWLESQD...WDTAA..----.S.........DESLSAVLFTNL...L....SQLDRVRAHEL............---..NFLQRHNMKMIQQQL......QVKYSSS....PVNMAKVISTCLREERRILSS--vc...........................
G1U4K1_RABIT/2-124                   ...................AGWIQAQQ...L...QG...DALRQMQVLYGQH.FPI.E...VRHYLAQWIESQP...WDAID..LDSP.Q.........DRAQAAQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QNTYDRC....PMELVRCIRHILYNEQRLVREA-n............................
E2RB82_CANLF/2-120                   ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
F7CHH2_MONDO/2-124                   ...................AVWIQAQQ...L...QG...DALHQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSID..LDNP.Q.........ENIKATQLLEGL...I....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QSTYDRC....PMELVRCIRHILYNEQRLVREA-t............................
Q8C3V4_MOUSE/2-120                   ...................SQWFELQQ...L...DS...KFLEQVHQLYDDS.FPM.E...IRQYLAQWLEKQD...WEHAA..----.Y.........DVSFATIRFHDL...L....SQLDDQYSRFS............LEN..NFLLQHNIRKSKRNL......QDNFQED....PVQMSMIIYNCLKEERKILENA-q............................
H0VML6_CAVPO/2-114                   ...................SLWSLVSK...V...SP...---EKLQRLYVD-.FPQ.H...LRHLLGDWLENQP...WEFLV..----.S.........SDAFCCNMASAL...L....SATVQRLQAST............GEQ..--GEGSTILQHISTL......ESIYQRD....PLKLVATFRQILQGEKKAVMEQ-f............................
A0A091QQB9_MERNU/2-124               ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QVRLGSAglagSLEIARIVARCLWEESRLLQTA-a............................
H2URF8_TAKRU/2-124                   ...................AVWIQAQQ...L...QG...DALHQMQSLYGQH.FPI.E...VRHYLSQWIEGQL...WDAID..LENP.Q.........EEFKAKRLLDSL...I....QELQNKAEHQM............GED..GFLLKIKLGHYASQL......KSTYDRC....PLELVRCIRHILYTEQRLVREA-t............................
I3IXW3_ORENI/2-120                   ...................AQWNQLQQ...L...ET...RYLEQLYHLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.N.........KESHATLVFHNL...L....GEIDQQYSRFL............QEN..NVLYQHNLRRIKQHL......QSKYLEK....PMDIARIVARCLWEEQRLLQTA-t............................
Q16V47_AEDAE/2-126                   ...................SLWARVNQ...L...PQ...PVLEQIRYIYGNS.FPI.E...VRHYLAEWIEERL...LNVPV..YQHE.Qd......saYEQEAATFLNQL...I....NELERTAINLP............-ED..NVTGRIRLNESARNF......RQLFSHN....PVQLYSHLINCLQRERQCIAY--pe...........................
G1SU42_RABIT/2-114                   ...................SLWGLVSK...M...PP...---EKLQRLYVD-.FPP.H...LRHLLGDWLETQP...WEFLV..GSDA.F.........CLSMASALFSAT...V....KRLQTSAGE--............--Q..--GEGSAILQPISTL......ESVYQRD....PLKLVAIFRQILQGEKKAVMEQ-f............................
H2QD18_PANTR/2-124                   ...................AVWIQAQQ...L...QG...EALHQMQALYGQH.FPI.E...VRHYLSQWIESQA...WDSID..LDNP.Q.........ENIKATQLLEGL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QNTYDRC....PMELVRCIRHILYNEQRLVREA-n............................
G1LB72_AILME/2-123                   ...................AQWEMLQN...L...SN...PFQDQLHQLYSESlLPM.D...IRQCLAVWIEDQN...WQEAA..--LG.N.........DDSKATVLFFHF...L....DQLNNECGRCS............QDP.dLLLLQHNLRKFSRDV......QA-FPQG....PTQLAEMIFNLLLEEKRILIQA-q............................
H2ZMV2_CIOSA/2-125                   ...................SLWAKVRE...L...EG...DSLRQIQNLYGQN.FPI.E...FRHYFADIIERQQ...WDQLD..PDNTpN.........DEPHAKYILDLF...L....GEIQKQCDSLI............EAR..DFVQRLHFSEIASHF......KNVYGPA....PLELVRTVKRILSIEKRLVQHA-h............................
G3TE30_LOXAF/2-123                   ...................AQWEMLQN...L...DS...PFQEQLHQLYSDSpLPV.D...VRQYLAVWIEDQN...WREAA..--LG.N.........DDSKANVLFHHF...L....GQLDDKCSPYN............EDP.eCLLLQHNMRKFARDI......QA-FPKG....PTQLAEMIFNLLLEEERILIQA-q............................
E2RI99_CANLF/2-120                   ...................SQWYELQQ...L...DS...KFLEQVHQLYDDC.FPM.E...IRQYLAQWLEKQD...WEHAA..----.N.........DVSFATIRFHDL...L....SQLDDQYSRFS............LEN..NFLLQHNIRKSKRNL......QDNFQED....PIQMSMIIYNCLKEERKILENA-q............................
G3HW32_CRIGR/1-105                   ................mpp--------...-...--...---EKLQRLYVD-.FPQ.H...LRHLLADWLESQP...WEFLV..----.G.........SDAFCYNMASAL...L....SATVQRLQTCA............GDQ..--GKGSTILQHISTL......ESIYQRD....PLKLVATIRQILQGEKKAVIE--ef...........................
V8NJ63_OPHHA/39-152                  ...................SLWSYVST...M...PP...---ERFNGLYEE-.FPH.T...LRCLLGEWLETEP...WEFIN..----.R.........SDSFCTLLAGRL...L....SAMVEKIRDLA............-NK..NCNSAAQILQFVANI......ESRYRKD....PLQLANIIKRILEAEQTAVHQQ-h............................
H3C088_TETNG/2-120                   ...................SQWGQLQM...L...DC...KYLEQVDQLYDDT.FPM.D...IRQYLSRWIESID...WETVA..----.M.........QDSLAMVRFHDL...L....AQLDDQHSRFA............LEN..KFLLQHNIRKIKRNL......QDRFQED....PVHMAMIISRNLKEEQRILDV--ak...........................
H3DAR7_TETNG/2-120                   ...................AQWDRLCS...L...SA...QYKQQLDELYDKDvLSM.E...VRHYLAVWIERQE...WKRAA..----.Q.........DYNLAMVLYQNL...L....DNLDIQYSRFV............HEV..AFLQQHNIRRYKQNF......QR-YQDD....PCLLASNILWYLEREKEILRNA-d............................
A0A0R4IZ47_DANRE/2-121               ...................AQWAQMTQ..hI...QF...LTTEVLNELYPVT.FPL.D...IRHYLASWIEGQQ...WDSFD..VDNR.E.........QESQAQLLSDQM...V....MLLHQVAKQNP............---..NVVEKVKLQHMSKNW......SV-LYPQ....PLQLVRTVREILRKERLILSQT-n............................
F1SLY5_PIG/2-123                     ...................AQWEMLQN...L...DS...PFQDQLHQLYSESlLPV.D...VRQYLAVWIEDQN...WQEAA..--LG.N.........DDSKANMLFFHF...L....DQLNYDCGRCG............QDP.eCLLLQHNLRKFYRDI......QA-IPQG....PTRLAEMIFNLLLEEKRILIQA-q............................
F1S0Q9_PIG/2-124                     ...................AGWIQAQQ...L...QG...DALRQMQVLYGQH.FPI.E...VRHYLAQWIESQP...WDAID..VDNP.Q.........DRAQATQLLENL...V....QELQKKAEHQV............GED..GFLLKIKLGHYATQL......QNTYDRC....PMELVRCIRHILYNEQRLVREA-n............................
F6SD10_CALJA/4-126                   ...................AGWIQAQQ...L...QG...DALRQMQVLYGQH.FPI.E...VRHYLAQWIESQP...WDAID..LDNP.Q.........DRAQATQLLEGL...V....QELQRKAEHQV............GED..GFLLKIKLGHYATQL......QKTYDRC....PMELVRCIRHILYNEQRLVREA-n............................
A0A0N1ID72_PAPMA/89-165              ...................--------...-...--...----RVRAIYGDH.FPI.E...VRHCLASWIESRI...WTT--..----.E.........PEEQQRYFVEEL...V....QEIQTNADLML............SPE..MFVTQMKLKEAANNF......RVQY---....-----------------------r............................
A0A0Q3PSP4_AMAAE/2-120               ...................AQWNQLQQ...L...DT...RYLEQLHQLYSDS.FPM.E...LRQFLAPWIESQD...WAYAA..----.S.........KESHATLVFHNL...L....GEIDQQYSRFL............QES..NVLYQHNLRRIKQFL......QSRYLEK....PMEIARIVARCLWEESRLLQTA-a............................
G1N4C3_MELGA/2-120                   ...................TQWYQLQQ...L...DS...KFLEQVHQLYDDS.FPM.E...IRQYLAQWLENQD...WEHAA..----.N.........NVSFATVLFHDL...L....SQLDDQFSRFL............IEN..NFLLQHNIRKSKRNL......QDNFQED....PIHMAMIIHNCLKEERKILNSA-q............................
K7GST8_PIG/3-121                     ...................SQWYELQQ...L...DS...KFLEQVHQLYDDS.FPM.E...IRQYLAQWLENQD...WEHAA..----.N.........DVSFATIRFHDL...L....SQLDDQYSRFS............LEN..NFLLQHNIRKSKRNL......QDNFQED....PIQMSMIICNCLKEERKILENA-q............................
Q1KQ07_RAT/2-114                     ...................SLWSLVSK...M...SP...---EKLQRLYVD-.FPQ.H...LRHLLAEWLENQP...WEFLV..----.G.........SDAFCYNMASAL...L....SATVQRLQASA............GEQ..--GKGSSLLQHISTL......ESIYQRD....PLKLVATIRQILQGEKKAVIE--ef...........................
#=GC SS_cons                         ...................-HHHHHHT...S...-C...CCHHHHHCTTSTT.S-H.H...HHHHTHHHHHHS-...HHHHT..----.T.........SHHHHHHHHHHH...H....HHHHHHHHHHH............HHT..-HHHHHHHHHHHHHH......HHHHCSS....HHHHHHHHHHHHHHHHHHHHHC-H............................
#=GC seq_cons                        ...................utWtplQQ...L...ps...chL-QlppLYscp.FPh.E...lRpaLApWIEsQs...W-ths.......s.........ccuhAohlhcsL...L....ppLppphs+hs............tEs..shLhppsLp+htppL......Qspapcs....PhclsthlpphLhpEp+llppA.p............................
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