GenomeNet

Database: Pfam
Entry: Scm3
LinkDB: Scm3
Original site: Scm3 
#=GF ID   Scm3
#=GF AC   PF10384.4
#=GF DE   Centromere protein Scm3
#=GF AU   Mistry J, Wood V
#=GF SE   Pfam-B_19394 (release 21.0)
#=GF GA   24.30 24.30;
#=GF TC   24.30 25.90;
#=GF NC   23.60 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17548816
#=GF RT   Scm3, an essential Saccharomyces cerevisiae centromere protein
#=GF RT   required for G2/M progression and Cse4 localization. 
#=GF RA   Stoler S, Rogers K, Weitze S, Morey L, Fitzgerald-Hayes M, Baker
#=GF RA   RE; 
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:10571-10576.
#=GF RN   [2]
#=GF RM   17704645
#=GF RT   Domain Architectures of the Scm3p Protein Provide Insights into
#=GF RT   Centromere Function and Evolution. 
#=GF RA   Aravind L, Iyer LM, Wu C; 
#=GF RL   Cell Cycle. 2007; [Epub ahead of print]
#=GF RN   [3]
#=GF RM   19563746
#=GF RT   Common ancestry of the CENP-A chaperones Scm3 and HJURP.
#=GF RA   Sanchez-Pulido L, Pidoux AL, Ponting CP, Allshire RC;
#=GF RL   Cell. 2009;137:1173-1174.
#=GF DR   INTERPRO; IPR018465;
#=GF CC   Scm3 is a centromere protein that has been shown in
#=GF CC   Saccharomyces cerevisiae to be required for G2/M progression and
#=GF CC   Cse4 localisation [1].  The C terminal region of Scm3 proteins
#=GF CC   is variable in size and sometimes consists of DNA binding motifs
#=GF CC   [2].
#=GF SQ   154
#=GS G9MIM2_HYPVG/42-98    AC G9MIM2.1
#=GS C4JIL3_UNCRE/21-77    AC C4JIL3.1
#=GS H0XC79_OTOGA/13-74    AC H0XC79.1
#=GS C9JWC4_HUMAN/16-77    AC C9JWC4.1
#=GS E7KLD2_YEASL/14-69    AC E7KLD2.1
#=GS F9FXH7_FUSOF/42-98    AC F9FXH7.1
#=GS H0GS94_9SACH/91-146   AC H0GS94.1
#=GS B2WCW5_PYRTR/21-77    AC B2WCW5.1
#=GS F0UEH6_AJEC8/28-84    AC F0UEH6.1
#=GS Q6FQS8_CANGA/88-143   AC Q6FQS8.1
#=GS G4T7M3_PIRID/46-100   AC G4T7M3.1
#=GS HJURP_MOUSE/9-70      AC Q6PG16.1
#=GS G7DWT9_MIXOS/158-216  AC G7DWT9.1
#=GS A7F2V5_SCLS1/58-114   AC A7F2V5.1
#=GS G2Q0Y3_THIHA/44-100   AC G2Q0Y3.1
#=GS F4RGM7_MELLP/43-98    AC F4RGM7.1
#=GS E7LSB8_YEASV/114-169  AC E7LSB8.1
#=GS C5P097_COCP7/23-79    AC C5P097.1
#=GS G8BNA8_TETPH/78-134   AC G8BNA8.1
#=GS G2WC22_YEASK/90-145   AC G2WC22.1
#=GS A5DBC2_PICGU/62-119   AC A5DBC2.2
#=GS A7TPC0_VANPO/78-133   AC A7TPC0.1
#=GS B9WDE2_CANDC/65-131   AC B9WDE2.1
#=GS G9P9Z1_HYPAI/42-98    AC G9P9Z1.1
#=GS HJURP_HUMAN/16-77     AC Q8NCD3.2
#=GS HJURP_HUMAN/16-77     DR PDB; 3R45 C; 16-74;
#=GS E3L991_PUCGT/32-89    AC E3L991.1
#=GS E7QCF0_YEASZ/114-169  AC E7QCF0.1
#=GS E4UYG6_ARTGP/24-80    AC E4UYG6.1
#=GS F0XT16_GROCL/86-142   AC F0XT16.1
#=GS C5E247_LACTC/124-179  AC C5E247.1
#=GS C4R6P8_PICPG/5-62     AC C4R6P8.1
#=GS Q99KB1_MOUSE/9-54     AC Q99KB1.1
#=GS C5JP41_AJEDS/28-84    AC C5JP41.1
#=GS E3L1F1_PUCGT/32-89    AC E3L1F1.2
#=GS C5DXK7_ZYGRC/103-172  AC C5DXK7.1
#=GS E9DIL8_COCPS/23-79    AC E9DIL8.1
#=GS D6RI36_MOUSE/9-70     AC D6RI36.1
#=GS E4ZX34_LEPMJ/22-78    AC E4ZX34.1
#=GS G7XQZ6_ASPKW/23-79    AC G7XQZ6.1
#=GS Q75A32_ASHGO/54-109   AC Q75A32.1
#=GS G8YMQ1_PICSO/75-132   AC G8YMQ1.1
#=GS A6QZJ3_AJECN/28-84    AC A6QZJ3.1
#=GS E9QKG8_MOUSE/9-70     AC E9QKG8.1
#=GS C9SH97_VERA1/40-94    AC C9SH97.1
#=GS H2P900_PONAB/16-77    AC H2P900.1
#=GS G3IET5_CRIGR/9-70     AC G3IET5.1
#=GS H2APV5_KAZAF/85-140   AC H2APV5.1
#=GS A9V3K2_MONBE/6-61     AC A9V3K2.1
#=GS C0RXJ4_PARBP/28-84    AC C0RXJ4.1
#=GS C5M9H4_CANTT/76-133   AC C5M9H4.1
#=GS F2PGM0_TRIEC/24-80    AC F2PGM0.1
#=GS C4YPV4_CANAW/75-132   AC C4YPV4.1
#=GS B5VFD1_YEAS6/111-166  AC B5VFD1.1
#=GS F8N4F4_NEUT8/40-96    AC F8N4F4.1
#=GS D4DBB3_TRIVH/24-80    AC D4DBB3.1
#=GS F7HTU6_MACMU/16-77    AC F7HTU6.1
#=GS F2RXR7_TRIT1/24-80    AC F2RXR7.1
#=GS F7HXV2_CALJA/16-77    AC F7HXV2.1
#=GS H0GDD5_9SACH/14-69    AC H0GDD5.1
#=GS F8WCV1_HUMAN/16-77    AC F8WCV1.1
#=GS C7YIG3_NECH7/42-98    AC C7YIG3.1
#=GS E7Q1S0_YEASB/114-169  AC E7Q1S0.1
#=GS E7NFK6_YEASO/114-169  AC E7NFK6.1
#=GS H8X5N7_9ASCO/85-142   AC H8X5N7.1
#=GS F2SJ61_TRIRC/24-80    AC F2SJ61.1
#=GS G2YPL0_BOTF4/56-112   AC G2YPL0.1
#=GS F4P5R9_BATDJ/77-133   AC F4P5R9.1
#=GS E6ZP97_SPORE/55-117   AC E6ZP97.1
#=GS F9XB39_MYCGM/22-78    AC F9XB39.1
#=GS F2TVR4_SALS5/1-54     AC F2TVR4.1
#=GS H6C8V8_EXODN/25-81    AC H6C8V8.1
#=GS G2WTA5_VERDV/40-94    AC G2WTA5.1
#=GS E9EN03_METAR/57-113   AC E9EN03.1
#=GS A6RN23_BOTFB/56-112   AC A6RN23.1
#=GS G1XB66_ARTOA/32-87    AC G1XB66.1
#=GS B8MXU0_ASPFN/25-81    AC B8MXU0.1
#=GS E3Q427_COLGM/42-98    AC E3Q427.1
#=GS G3Y6N0_ASPNA/23-79    AC G3Y6N0.1
#=GS G0W3I4_NAUDC/121-176  AC G0W3I4.1
#=GS A6ZXI8_YEAS7/90-145   AC A6ZXI8.1
#=GS G0RNL9_HYPJQ/42-98    AC G0RNL9.1
#=GS B6HFY5_PENCW/24-80    AC B6HFY5.1
#=GS Q5BD66_EMENI/25-81    AC Q5BD66.1
#=GS G8ZRI1_TORDC/85-140   AC G8ZRI1.1
#=GS H1UXR2_COLHI/45-101   AC H1UXR2.1
#=GS G5BRP6_HETGA/14-75    AC G5BRP6.1
#=GS Q5KGL1_CRYNJ/73-127   AC Q5KGL1.1
#=GS D4AQQ4_ARTBC/24-80    AC D4AQQ4.1
#=GS G3AYT2_CANTC/59-116   AC G3AYT2.1
#=GS C4Y1C7_CLAL4/61-118   AC C4Y1C7.1
#=GS A3LNZ2_PICST/72-129   AC A3LNZ2.2
#=GS E1BB33_BOVIN/9-70     AC E1BB33.2
#=GS E3RL97_PYRTT/21-77    AC E3RL97.1
#=GS D6RP57_COPC7/84-138   AC D6RP57.1
#=GS C8Z6G3_YEAS8/114-169  AC C8Z6G3.1
#=GS H0V4F5_CAVPO/9-70     AC H0V4F5.1
#=GS B6QLW7_PENMQ/18-74    AC B6QLW7.1
#=GS Q6C0K7_YARLI/113-163  AC Q6C0K7.1
#=GS B3LH30_YEAS1/90-145   AC B3LH30.1
#=GS F2TMH5_AJEDA/28-84    AC F2TMH5.1
#=GS A5DY01_LODEL/98-155   AC A5DY01.1
#=GS B8MF98_TALSN/22-78    AC B8MF98.1
#=GS B2AYH7_PODAN/45-101   AC B2AYH7.1
#=GS Q4P5I5_USTMA/62-124   AC Q4P5I5.1
#=GS A1DBC6_NEOFI/22-78    AC A1DBC6.1
#=GS A2R8L1_ASPNC/12-68    AC A2R8L1.1
#=GS YK12_SCHPO/36-92      AC Q9HDY7.1
#=GS G4N6Q0_MAGO7/32-86    AC G4N6Q0.1
#=GS D4A1W1_RAT/9-70       AC D4A1W1.1
#=GS Q6MUT0_NEUCS/40-96    AC Q6MUT0.1
#=GS G3AR81_SPAPN/43-99    AC G3AR81.1
#=GS Q7SFX1_NEUCR/40-96    AC Q7SFX1.2
#=GS G8JWY5_ERECY/65-119   AC G8JWY5.1
#=GS E7KAE4_YEASA/90-145   AC E7KAE4.1
#=GS F7B865_HORSE/1-60     AC F7B865.1
#=GS C1H1L9_PARBA/28-84    AC C1H1L9.1
#=GS E9Q4T0_MOUSE/9-70     AC E9Q4T0.1
#=GS F7VXN2_SORMK/40-96    AC F7VXN2.1
#=GS F7HXU7_CALJA/16-77    AC F7HXU7.1
#=GS B0CVA8_LACBS/134-189  AC B0CVA8.1
#=GS C6HLE5_AJECH/28-84    AC C6HLE5.1
#=GS G2R3B6_THITE/39-95    AC G2R3B6.1
#=GS I1RAY3_GIBZE/42-98    AC I1RAY3.1
#=GS Q55S59_CRYNB/73-127   AC Q55S59.1
#=GS C5GU13_AJEDR/28-84    AC C5GU13.1
#=GS G1PWU4_MYOLU/16-77    AC G1PWU4.1
#=GS B6K7K7_SCHJY/41-97    AC B6K7K7.1
#=GS F2R0E2_PICP7/5-62     AC F2R0E2.1
#=GS G8BGU0_CANPC/83-140   AC G8BGU0.1
#=GS B8P9Z9_POSPM/72-127   AC B8P9Z9.1
#=GS C5FZ18_ARTOC/25-81    AC C5FZ18.1
#=GS C1G5U3_PARBD/28-84    AC C1G5U3.1
#=GS G3QJI6_GORGO/15-76    AC G3QJI6.1
#=GS Q0D1N2_ASPTN/23-79    AC Q0D1N2.1
#=GS B5RTJ1_DEBHA/81-138   AC B5RTJ1.1
#=GS Q5AJC3_CANAL/75-132   AC Q5AJC3.1
#=GS B8NZI3_POSPM/72-127   AC B8NZI3.1
#=GS Q497U4_MOUSE/9-54     AC Q497U4.1
#=GS G8YDX1_PICSO/75-132   AC G8YDX1.1
#=GS Q6CL77_KLULA/61-116   AC Q6CL77.1
#=GS Q6CL77_KLULA/61-116   DR PDB; 2YFV C; 61-103;
#=GS E9EBN8_METAQ/84-140   AC E9EBN8.1
#=GS B0Y9U8_ASPFC/22-78    AC B0Y9U8.1
#=GS C7GKZ1_YEAS2/90-145   AC C7GKZ1.1
#=GS G1RAT8_NOMLE/16-77    AC G1RAT8.1
#=GS Q4WCA0_ASPFU/22-78    AC Q4WCA0.1
#=GS SCM3_YEAST/90-145     AC Q12334.2
#=GS SCM3_YEAST/90-145     DR PDB; 2L5A A; 84-136;
#=GS H2QJN4_PANTR/16-77    AC H2QJN4.1
#=GS A1C460_ASPCL/23-79    AC A1C460.1
#=GS F1SM16_PIG/11-72      AC F1SM16.1
#=GS C0NG62_AJECG/28-84    AC C0NG62.1
#=GS E6R769_CRYGW/73-127   AC E6R769.1
#=GS G4U7Y1_NEUT9/40-96    AC G4U7Y1.1
#=GS G3S556_GORGO/9-70     AC G3S556.1
#=GS G0V8Z8_NAUCC/113-168  AC G0V8Z8.1
G9MIM2_HYPVG/42-98               .........yk--LSIERAYADQRFQATMAHIFEKYGR-DF.EGIG.DEIDL...ETGE...IVVNNGHVRNMRDE-g..............
C4JIL3_UNCRE/21-77               ..........i-NVDEARKANDLRLKSCFESICEKYGK-DF.RNVG.DEIDL...ETGQ...IVVDNGHLHQMEAED...............
H0XC79_OTOGA/13-74               .........dm--LLQKLRDSRRRFQRRMQELIEKYNQPFE.DDPL.VQMATltyETPQ..gLRIWGGRLIKERNK-g..............
C9JWC4_HUMAN/16-77               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
E7KLD2_YEASL/14-69               ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
F9FXH7_FUSOF/42-98               ..........i-QLALKRANADHKLQATMAHIIEKYSR-DF.EGIG.DEIDM...NTGE...IVVNNGHLRNMRDE-g..............
H0GS94_9SACH/91-146              ...........DEVMERHKRADENMKEVWSNIISKYESI--.EDQG.DLVDL...KTGE...IIEDNGHIKKLT---vns............
B2WCW5_PYRTR/21-77               ...........EEYINAKRKQQQKFKGRLESIFDKYGS-MH.ESMS.DEIDM...KLNR...VVVDRGHLRRLKRQ-v..............
F0UEH6_AJEC8/28-84               ..........i-DVSAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMRNE-q..............
Q6FQS8_CANGA/88-143              ...........EEVMEKHKLADQRMKTVWSNIIDKYSNV--.VDEG.DVIDL...QSGE...IITDNGHIRNLNT--gf.............
G4T7M3_PIRID/46-100              ..........q-ELEAQRRASRQRVLSVWESLEKRYHR-DL.DDD-.DIVDL...ESMT...LIQDAGTLRQIK---dv.............
HJURP_MOUSE/9-70                 ..........r-RLHQQLKESSSRFQTLMKRLIAKYNQPFE.DDPL.VEMRTltyETPQ..gLRVWGGKLMKKED--ke.............
G7DWT9_MIXOS/158-216             ...........EDVPRLRYEAAVKLRTTWDDIAAKYSRPEYgEDQD.DIIDI...ETGD...IIKDRGRLRALSE--dq.............
A7F2V5_SCLS1/58-114              ..........q-ELQQRRARLDYKLKSTFESIFEKYGK-DF.DGVG.DEIDL...LTGE...ILVDNGHLKEMQDE-r..............
G2Q0Y3_THIHA/44-100              ..........a-RLERSRAFAALKLKSAFERIFEKYGH-DF.TGVA.DEIDL...RTGR...IVVDNGHIQSLKD--aq.............
F4RGM7_MELLP/43-98               ...........DDIDSLRTQSIKTFQSNLQTIYSKYEGDGD.EEAD.DVVDL...VKLE...VIEDRGKIIK-----tlg............
E7LSB8_YEASV/114-169             ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
C5P097_COCP7/23-79               ..........v-NIHEARRANNLRLKSRLELIYQKYGR-DF.GNIG.DEINL...RTGQ...IVVDNGHLNQMENE-q..............
G8BNA8_TETPH/78-134              ..........a-EVLLKHKVADENMKKTWLDIISKYENPEN.QN-S.DVIDL...KTGE...IVEDNGHLRTLLN--nr.............
G2WC22_YEASK/90-145              ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
A5DBC2_PICGU/62-119              ..........k-RVANLQARSRTRFQNQWEAILEKYSQIDD.EKES.DEIDL...STGE...IITDNGHLRALARK-d..............
A7TPC0_VANPO/78-133              ...........EEILMKHKRADENMKSTWQNIISKYEKF--.EGPS.DVIDL...NTGE...IVEDNGHIRNLNNE-a..............
B9WDE2_CANDC/65-131              nqqnerqfkhk--FKQMENQSLQRFKSQWDAIIDKYSKIDD.STQS.DEIDI...VTGE...LITNNGHLDKLNQN-h..............
G9P9Z1_HYPAI/42-98               .........yk--LSIERAYADQRFQATMAHIFDKYGR-DF.EGIG.DEIDL...VTGE...IVVNNGHVHNMRDE-g..............
HJURP_HUMAN/16-77                ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
#=GR HJURP_HUMAN/16-77     SS    ...........HHHHHHHHHHHHHHHHHHHHHHHHH-S--T.TS-E.EBTTTTEEEETT..EEEETTS-EEEE-XX-X..............
E3L991_PUCGT/32-89               .........en--ICALRNRSMRKFVRALESIAARYEG-DG.DEESdDVIDL...DQLQ...VIEDRGYI-------lkrlshn........
E7QCF0_YEASZ/114-169             ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
E4UYG6_ARTGP/24-80               ..........f-DVNKARKANNLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-h..............
F0XT16_GROCL/86-142              ..........y-RLEMSRAAADNKLKSAFESLFEKYGK-DF.GDTG.DEINF...YTDE...IEVDNGHIASLPN--aq.............
C5E247_LACTC/124-179             ...........EQVMSRHKQADENMKRVWAHLIEKYGSL--.EDQG.DVLDL...ATGE...IIEDNGHVRGLGTQ-t..............
C4R6P8_PICPG/5-62                ..........r-TYAELLEKQGERLQKRWRSIIDKYSKVDL.DEQG.DLIDL...HTGE...IVEDNGHLESVSS--rk.............
Q99KB1_MOUSE/9-54                ..........r-RLHQQLKESSSRFQTLMKRLIAKYNQPFE.DDPL.VEMRT...----...---------------ltyetpq........
C5JP41_AJEDS/28-84               ..........i-DISAARQANDMRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMTNE-q..............
E3L1F1_PUCGT/32-89               .........en--ICALRNRSMRKFVRALESIAARYEG-DG.DEESdDVIDL...DQLQ...VIEDRGYI-------lkrlshn........
C5DXK7_ZYGRC/103-172             ...........DEVMKLHKKADENMKQVWNDIIAKYEAV--.ENQG.DVIDL...QTGE...LIEDNGHIRGISHE-nsetryasslkglid
E9DIL8_COCPS/23-79               ..........v-NIHEARRANNLRLKSRLELIYQKYGR-DF.GNIG.DEINL...RTGQ...IVVDNGHLNQMENE-q..............
D6RI36_MOUSE/9-70                ..........r-RLHQQLKESSSRFQTLMKRLIAKYNQPFE.DDPL.VEMRTltyETPQ..gLRVWGGKLMKKED--ke.............
E4ZX34_LEPMJ/22-78               ...........EDYINAKKAQEKRLKSRMESIFAKYEN-MH.ESNS.DIIDM...KKNR...VVVDRGHLRRLQRQ-v..............
G7XQZ6_ASPKW/23-79               ..........m-DIHEARAQNDLRLKSIFEGIFEKYGK-DF.TNVG.DEIDL...QTGN...IIVNNGHIQAMEGED...............
Q75A32_ASHGO/54-109              ..........a-EVMERHRRADENMKQAWTRIIEKYEAL--.DDQG.DVVDL...RTGE...IVEDNGHIRGLAD--gv.............
G8YMQ1_PICSO/75-132              ..........a-EITRLKSQSTKNFKNKWEEILAKYSSIDD.EKQS.DEIDL...ATGE...IIKDNGHLRSLGA--rn.............
A6QZJ3_AJECN/28-84               ..........i-DVSAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMRNE-q..............
E9QKG8_MOUSE/9-70                ..........r-RLHQQLKESSSRFQTLMKRLIAKYNQPFE.DDPL.VEMRTltyETPQ..gLRVWGGKLMKKED--ke.............
C9SH97_VERA1/40-94               ..........l-QLAESRAFAAYKLKSTFEHIFEKYER-DF.TGIG.DEIDL...RTGE...IVVDNGHIQQL----gl.............
H2P900_PONAB/16-77               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DAPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
G3IET5_CRIGR/9-70                ..........n-RLLRHLQESRNRFQTFMHRLIAKYNQPFE.DDPL.VQMSTltyETPQ..gLRVWGGKLIKEKSK-e..............
H2APV5_KAZAF/85-140              ...........DEIMAKHKKADETMKTVWNNIIDKYENL--.DDQG.DLIDL...QKGE...ILEDNGHIRNLGQN-g..............
A9V3K2_MONBE/6-61                ..........d-IVAEGHRQSEHKLCRSIEAIIAKYSH-EF.PD-S.DVVDL...EAMV...ICEDRGELKSGNA--hl.............
C0RXJ4_PARBP/28-84               ..........i-DVNAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGR...IIIDNGHIEKMRNE-q..............
C5M9H4_CANTT/76-133              ..........k-KYNELKDESLRKFYQRNQEIFNKYSQIDD.SKES.DEIDI...LTGE...IITNNGHLDRISGN-d..............
F2PGM0_TRIEC/24-80               ..........f-DVNQARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-h..............
C4YPV4_CANAW/75-132              ..........n-KFKQLENQSLQRFKSQWDAIIDKYSKIDD.STQS.DEIDI...VTGE...LITNNGHLDKLNQN-h..............
B5VFD1_YEAS6/111-166             ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
F8N4F4_NEUT8/40-96               ..........y-QLEQARSFAAFKLKSAFENIFEKYGK-DF.DGIG.DEIDL...RTGA...IVVDNGHIKSLKT--at.............
D4DBB3_TRIVH/24-80               ..........f-DVNQARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVLDNGHLTEMGDE-h..............
F7HTU6_MACMU/16-77               .........dp--LLQKLRASRRRFQRRMQLLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-r..............
F2RXR7_TRIT1/24-80               ..........f-DVNQARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-h..............
F7HXV2_CALJA/16-77               .........ep--LLQKLRASRRRFQRRMQRLLEKYDQPFE.DAPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
H0GDD5_9SACH/14-69               ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
F8WCV1_HUMAN/16-77               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
C7YIG3_NECH7/42-98               ........iqf---ALKRANANHKLQATMAHIIEKYSR-DF.EGVG.DEIDM...ETGE...IVVNNGHLRNMRDE-g..............
E7Q1S0_YEASB/114-169             ...........DEVMERHXLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
E7NFK6_YEASO/114-169             ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
H8X5N7_9ASCO/85-142              ..........a-KLKRLEKESLRRFENKWTGIISKYSNIND.DRES.DEIDL...VTGE...IVTNNGHLNRLRS--gg.............
F2SJ61_TRIRC/24-80               ..........f-DVNQARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-h..............
G2YPL0_BOTF4/56-112              ..........q-ELQQKRARLDYKLKSTFESIFEKYGK-DF.DGVG.DEIDL...LTGE...ILVDNGHLKEMQDE-r..............
F4P5R9_BATDJ/77-133              ...........EDVAKLRTESLERLKSTWEIICSKYGR-SF.EGES.DEIDL...TTGR...IVIDRGFLKRSHS--ka.............
E6ZP97_SPORE/55-117              ...........ETVEYLHQQSTQRLKRKWDSIFERFKDAHL.QEQ-.DEIYLgnrANGEpivMVKDRGSLRSLRQSM...............
F9XB39_MYCGM/22-78               ..........r-QLELARNQNDQKLKSRFERIFRKYEH-DF.TDVG.DEIDI...ESGD...IVVDNGHLQNMRDE-a..............
F2TVR4_SALS5/1-54                ..........m---EQERLESISNFKSALENIIAKYSHA-F.ENT-.DVIDL...ETNT...IVENYGLIESLGN--pn.............
H6C8V8_EXODN/25-81               ..........s-DLDALRYKNDSLLKSRFESIFAKYSQ-DF.SGVG.DEIDI...VQQK...IVVNNGHLESMEGE-t..............
G2WTA5_VERDV/40-94               ..........f-QLAESRAFAAYKLKSTFEHIFEKYER-DF.TGIA.DEIDL...RTGE...IVVDNGHIQRL----gl.............
E9EN03_METAR/57-113              ..........y-QLAIEKAYADNRFRATMAHIFRKYGR-DF.EGIG.DEIDL...STGE...IVVNNGHIENMRNE-v..............
A6RN23_BOTFB/56-112              ..........q-ELQQKRARLDYKLKSTFESIFEKYGK-DF.DGVG.DEIDL...LTGE...ILVDNGHLKEMQDE-r..............
G1XB66_ARTOA/32-87               ........ieh---ENSLRQSAQRLKTSWEDICRRYGR-DF.DGRA.DEIDL...RTGE...LVIDNGHLRGLE---ed.............
B8MXU0_ASPFN/25-81               ..........i-DLQEARAQNDQRLKSIFEGIFEKYGK-DF.TDVG.DEIDL...QTGK...IVVNNGHIQGMEDED...............
E3Q427_COLGM/42-98               ..........f-QLEQSRAFAAFKLKSTFEHIFQKYER-DF.TGIG.DEIDL...RTGE...IITDNGHLSSMRNE-r..............
G3Y6N0_ASPNA/23-79               ..........m-DIHEARAQNDLRLKSIFEGIFEKYGK-DF.TDVG.DEIDL...QTGN...IIVNNGHIQAMEGED...............
G0W3I4_NAUDC/121-176             ...........DEVMERHKKADETMKEVWTNIINKYESV--.ETQG.DLIDL...KTGE...IIEDNGHIRGLQH--gh.............
A6ZXI8_YEAS7/90-145              ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
G0RNL9_HYPJQ/42-98               ........ykl---SVERAYADQRFQATMAHIFEKYGR-DF.EGIG.DEIDL...VTGE...IVVNNGHVRNMRDE-g..............
B6HFY5_PENCW/24-80               ..........f-DLPAARAQNDSRLKSLFEGIFAKYSQ-DF.TDIG.DEIDL...QTGD...IVVDNGHLLGMRGED...............
Q5BD66_EMENI/25-81               ..........i-DLQEARTQNDLRLKSIFEGIFEKYGR-DF.TDVG.DEIDL...QTGK...ITVNNGHIDALEVE-g..............
G8ZRI1_TORDC/85-140              ...........DEIMQRHKLADENMKTAWTSIINKYESV--.EDQG.DVIDL...RTGE...VVEDYGHLRGLSHE-l..............
H1UXR2_COLHI/45-101              ..........y-QLEQSRAFAAFKLKSTFEHIFQKYER-DF.TGIG.DEIDL...RTGR...IIENNGHLERMRNE-r..............
G5BRP6_HETGA/14-75               ........dpl---LHKLSDSRRRFQRRMQQLIAKYEHPFE.DAPL.VEMSTltyKTPQ..gLRIWGGKLVKEV---nkg............
Q5KGL1_CRYNJ/73-127              ...........EELARRRQESRDKLKSSWDLLFEKYRDV-E.DD--.DEIDL...ATGT...IVKDRGKLRALQQP-m..............
D4AQQ4_ARTBC/24-80               ..........f-DVNQARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-h..............
G3AYT2_CANTC/59-116              ...........EEIDKLKIASNKKFLTKWEEILQKYSQIDD.DVES.DEIDL...VTGQ...ITIDNGHLRSLRNE-t..............
C4Y1C7_CLAL4/61-118              ..........n-RLRQLKQDSSARFLRRWDEIISKYSQIDD.NTQS.DEIDL...RTGE...IVRDNGHLRSLAT--dg.............
A3LNZ2_PICST/72-129              ...........EELHRLKTKSSQKFRTKWEEILAKYSSIDD.EKES.DEIDL...ATGK...IVVDNGHLRSLHD--gn.............
E1BB33_BOVIN/9-70                ...........DELLMKLRDSRCRFQRRMQQLIEKYNQPFE.DGPV.IQMSTltyQTPQ..gLRIWGGGLVK-----rstgh..........
E3RL97_PYRTT/21-77               ...........EEYINAKRKQQQMFKGRLESIFDKYGS-MH.ESMS.DEIDM...KLNR...VVVDRGHLRRLKRQ-v..............
D6RP57_COPC7/84-138              ..........i-DFQQKRQASALRLLDVWSKLAERYTRRLD.ED--.DIVDI...VSGR...IVKDNGVLRKSKT--v..............
C8Z6G3_YEAS8/114-169             ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
H0V4F5_CAVPO/9-70                ......dtlvl-----KLRETRRRFQRRMQQLIAKYEHPFE.DDPL.VHMSTltyKTPK..gLRFWGGRLITETNQ-g..............
B6QLW7_PENMQ/18-74               ..........n-DLQIARARNDQKLKSLFEGIFEKYGK-DF.SDIG.DEIDL...STGE...IVINKGHVQRMEHED...............
Q6C0K7_YARLI/113-163             ........sfs--------ASLAMFEKEWNSIIDKYSNV--.EDQG.DVVDL...ASGS...IVKNNGHLELLEDE-e..............
B3LH30_YEAS1/90-145              ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-k..............
F2TMH5_AJEDA/28-84               ..........i-DISAARQANDMRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMTNE-q..............
A5DY01_LODEL/98-155              .........el--IKKLEAESLAKAKDRWSKIIDKYSQIND.DAVS.DEIDI...VSGR...VVRDNGHLRRMKVK-r..............
B8MF98_TALSN/22-78               ..........v-DLQIARAQNDQKLKSLFEGIFKKYGK-DF.SDIG.DEIDL...RTGE...IVVNKGHVQRMEHED...............
B2AYH7_PODAN/45-101              ..........a-RLERSRQRAVNKLKTAFESIFERYGR-DF.EGVG.DEVDL...RTGR...IVVNNGHIEGMRGS-d..............
Q4P5I5_USTMA/62-124              ...........ETVEYLHQQSTQRLKRKWDSIFERFKDAHL.QEQ-.DEIYLgnrANGEpivVVKDRGSLRSLRQSM...............
A1DBC6_NEOFI/22-78               ..........i-DLQEARAQNDLRLKSIFERIFEKYGK-DF.TDIG.DEIDL...QTGK...IVVNNGHLQRMSGED...............
A2R8L1_ASPNC/12-68               ..........m-DIHEARAQNDLRLKSIFEGIFEKYGK-DF.TDVG.DEIDL...QTGN...IIVNNGHIQAMEGED...............
YK12_SCHPO/36-92                 ...........DDVFCKRIESEKKYNDFLESLFKKYGR-DT.SDIA.DEVDL...ATGE...IIVNNGHLEALKTKD...............
G4N6Q0_MAGO7/32-86               ........rqf---QRSTYRSAFSFKSTLENIFEKYGR-DF.GDEG.DEIDL...NTGE...ITVDRGHFRG-----ifg............
D4A1W1_RAT/9-70                  .........rp--LDQRLKESSRRFQTYMQRLIAKYNQPFE.DDPL.VQMATltyETPQ..gLRVWGGKLIKEEDE-e..............
Q6MUT0_NEUCS/40-96               ..........y-QLEQARSFAAFKLKSAFENIFEKYGK-DF.DGIG.DEIDL...RTGA...IVVDNGHIKSLKT--at.............
G3AR81_SPAPN/43-99               .........ni--IQKHQKRNLDKFWSKWNQIIDKYSQI-D.PEEG.DEISL...HTGQ...ITIDNGHLKSLP---erg............
Q7SFX1_NEUCR/40-96               ..........y-QLEQARSFAAFKLKSAFENIFEKYGK-DF.DGIG.DEIDL...RTGA...IVVDNGHIKSLKT--at.............
G8JWY5_ERECY/65-119              ...........EEVMERHRRADENMKQAWADIIEKYESV--.EDQG.DVVDL...QTGE...IVEDNGHIRSIQ---sf.............
E7KAE4_YEASA/90-145              ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
F7B865_HORSE/1-60                ...........--LQQKLRDSRRRFQRRMQRLIEKYNQPFE.DAPL.VQMSTltyETPQ..gLRIWGGGLVKERNE-g..............
C1H1L9_PARBA/28-84               ..........i-DVNAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGR...IIIDNGHIEKMRNE-q..............
E9Q4T0_MOUSE/9-70                ..........r-RLHQQLKESSSRFQTLMKRLIAKYNQPFE.DDPL.VEMRTltyETPQ..gLRVWGGKLMKKED--ke.............
F7VXN2_SORMK/40-96               ..........y-QLEKARSYAAFKLKSAFENIFEKYGK-DF.DGIG.DEIDL...RTGE...IVVDNGHIKSLKTN-t..............
F7HXU7_CALJA/16-77               .........ep--LLQKLRASRRRFQRRMQRLLEKYDQPFE.DAPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
B0CVA8_LACBS/134-189             ..........l-DLQKEREASTLRLLDVWSQLAERYTRRLD.ED--.DIVDI...RTGE...IVKDNGVIRKSRK--le.............
C6HLE5_AJECH/28-84               ..........i-DVSAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMRNE-q..............
G2R3B6_THITE/39-95               ..........v-QLERSRAFAAFKLKSAFERIFEKYEK-DF.TGVG.DEIDL...RTGE...IVVDNGHIQSLKNA-q..............
I1RAY3_GIBZE/42-98               ..........i-QLALKRVNANQKLHATMAHIIEKYSR-DF.EGIG.DEIDM...ATGE...IVVNNGHLRNMRDE-g..............
Q55S59_CRYNB/73-127              ...........EELARRRQESRDKLKSSWDLLFEKYRDV-E.DD--.DEIDL...ATGT...IVKDRGKLRALQQP-m..............
C5GU13_AJEDR/28-84               ..........i-DISAARQANDMRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMTNE-q..............
G1PWU4_MYOLU/16-77               .........dv--LMQKLKKSRHRFQRHMQQLLEKYNQPFE.DAPV.VQMSTltyETPQ..gLRIWGGRLEKEKSK-g..............
B6K7K7_SCHJY/41-97               ..........k-NLACQRVASRQRYEAKLSALFEKYGQ-DT.SEYA.DEIDL...ATGA...IVVDHGHLRGLHPH-t..............
F2R0E2_PICP7/5-62                ..........r-TYAELLEKQGERLQKRWRSIIDKYSKVDL.DEQG.DLIDL...HTGE...IVEDNGHLESVSS--rk.............
G8BGU0_CANPC/83-140              ..........a-KLKRLEKESLRRFENKWTGIISKYSNIND.ERES.DEIDL...VTGD...IITNNGHLHRLRSG-d..............
B8P9Z9_POSPM/72-127              ..........y-HIRESIKASSLRLLDFWAQLGERYDRPLD.ED--.DIIDL...RDGT...IVKDRGVLRGSPTK-y..............
C5FZ18_ARTOC/25-81               ..........f-DVNEARKANDLRLKSRFESIFEKYGK-DF.SSVG.DEIDL...AKGT...IVVDNGHLTEMGDE-r..............
C1G5U3_PARBD/28-84               ..........i-DVNAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGR...IIIDNGHIEKMRNE-q..............
G3QJI6_GORGO/15-76               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
Q0D1N2_ASPTN/23-79               ..........m-DLQEARAQNDLRLKSIFESIFEKYGK-DF.TEVG.DEIDL...NTGD...IIVNNGHIFTMEGE-d..............
B5RTJ1_DEBHA/81-138              ..........a-EINRLKKQSTNRFKSKWEEILEKYAQIDD.EKES.DEIDL...ASGE...IITDNGHLRSLRT--gi.............
Q5AJC3_CANAL/75-132              ..........n-KFKQLENQSLQRFKSQWDAIIDKYSKIDD.STQS.DEIDI...VTGE...LITNNGHLDKLNQN-h..............
B8NZI3_POSPM/72-127              ..........y-HIRESIKASSLRLLDFWAQLGERYDRPLD.ED--.DIIDL...RDGT...IVKDRGVLRGSPTK-y..............
Q497U4_MOUSE/9-54                .........rw--LHQQLNESRSRFQTLMKRLIAKYNQPFE.DDPL.VEMRT...----...---------------ltyetpq........
G8YDX1_PICSO/75-132              ..........a-EITRLKSQSTQNFKNKWEEILAKYSQIDD.EKES.DEIDL...ATGQ...IIKDNGHLRSLG---ars............
Q6CL77_KLULA/61-116              ...........EEVMERHKKADENMKRVWSQIIQKYESI--.DNQG.DVIDL...QTGE...VIEDNGHLRNLSNE-k..............
#=GR Q6CL77_KLULA/61-116   SS    ...........HHHHHHHHHHHHHHHHHHHHHHHHHHSG--.GGSS.--B-T...TT-S...B-XXXXXXXXXXXX-X..............
E9EBN8_METAQ/84-140              ..........y-QLAIEKAYADNRFRATMVHIFRKYGR-DF.EGIG.DEIDL...STGE...IVVNNGHIENMRNE-v..............
B0Y9U8_ASPFC/22-78               ..........i-DLQEARAQNDLRLKSIFERIFEKYGK-DF.TDIG.DEIDL...QTGK...IVVNNGHLQRMSSE-g..............
C7GKZ1_YEAS2/90-145              ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
G1RAT8_NOMLE/16-77               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNG-e..............
Q4WCA0_ASPFU/22-78               ..........i-DLQEARAQNDLRLKSIFERIFEKYGK-DF.TDIG.DEIDL...QTGK...IVVNNGHLQRMSSE-g..............
SCM3_YEAST/90-145                ...........DEVMERHKLADENMRKVWSNIISKYESI--.EEQG.DLVDL...KTGE...IVEDNGHIKTLTAN-n..............
#=GR SCM3_YEAST/90-145     SS    ...........XXX-HHHHHHHHHHHHHHHHHHHHHTT---.---S.---SS...SS--...---------S------..............
H2QJN4_PANTR/16-77               ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
A1C460_ASPCL/23-79               ..........i-DLQEARAHNDLRLKSIFEGIFEKYGK-DF.TEVG.DEIDL...QTGA...IVVNNGHLRGMSSED...............
F1SM16_PIG/11-72                 ...........DELLQKLRDSRRRFQRRMQQLIEKYDQPFE.DGPV.VQMSTltyETPQ..gFRIWGGGLVKERN--pg.............
C0NG62_AJECG/28-84               ..........i-DVSAARQANDLRLKSRFEDIFEKYGK-DF.SSVG.DEIDL...ATGN...IVIDNGHIERMKNE-q..............
E6R769_CRYGW/73-127              ...........EELARRRQESRDKLKSSWDLLFEKYRDV-E.DD--.DEIDL...STGT...IVKDRGKLRALQQP-m..............
G4U7Y1_NEUT9/40-96               ..........y-QLEQARSFAAFKLKSAFENIFEKYGK-DF.DGIG.DEIDL...RTGA...IVVDNGHIKSLKT--at.............
G3S556_GORGO/9-70                ...........DQLLQKLRASRRRFQRRMQRLIEKYNQPFE.DTPV.VQMATltyETPQ..gLRIWGGRLIKERNE-g..............
G0V8Z8_NAUCC/113-168             ...........DEVMERHKKADETMKEVWTNIINKYESM--.KNQG.DLINL...QTGE...IIEDNGHIKGLNHE-y..............
#=GC SS_cons                     ...........HHHHHHHHHHHHHHHHHHHHHHHHHCSG-T.CCSS.EBCTTTEECCTT..EEEETTS-EECE-----..............
#=GC seq_cons                    ............cltpt+ptucp+h+stappIh-KYsp....-s.u.DEIDL...pTGp...IlhDNGHlcphpsp.t..............
//
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