GenomeNet

Database: Pfam
Entry: Sda
LinkDB: Sda
Original site: Sda 
#=GF ID   Sda
#=GF AC   PF08970.7
#=GF DE   Sporulation inhibitor A
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1pv0
#=GF GA   22.60 22.60;
#=GF TC   22.80 29.40;
#=GF NC   19.20 22.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Sda_protein_domain
#=GF RN   [1]
#=GF RM   15023339
#=GF RT   Structure and mechanism of action of Sda, an inhibitor of the
#=GF RT   histidine kinases that regulate initiation of sporulation in
#=GF RT   Bacillus subtilis. 
#=GF RA   Rowland SL, Burkholder WF, Cunningham KA, Maciejewski MW,
#=GF RA   Grossman AD, King GF; 
#=GF RL   Mol Cell. 2004;13:689-701.
#=GF DR   INTERPRO; IPR015064;
#=GF CC   Members of this protein family contain two antiparallel alpha
#=GF CC   helices that are linked by a highly structured inter-helix loop
#=GF CC   to form a helical hairpin; the structure is stabilised by
#=GF CC   numerous hydrophobic and electrostatic interactions. These
#=GF CC   sporulation inhibitors are antikinases that bind to the
#=GF CC   histidine kinase KinA phosphotransfer domain and act as a
#=GF CC   molecular barricade that inhibit productive interaction between
#=GF CC   the ATP binding site and the phosphorylatable KinA His residue.
#=GF CC   This results in the inhibition of sporulation (by preventing
#=GF CC   phosphorylation of spo0A) [1].
#=GF SQ   80
#=GS I3EAR3_BACMT/1-45       AC I3EAR3.1
#=GS D5DMR5_BACMD/1-45       AC D5DMR5.1
#=GS C2X2V4_BACCE/1-45       AC C2X2V4.1
#=GS E6TW06_BACCJ/7-51       AC E6TW06.1
#=GS L0EGN8_THECK/1-42       AC L0EGN8.1
#=GS K0J3Q8_AMPXN/1-40       AC K0J3Q8.1
#=GS A0A0F5I0K3_9BACI/1-42   AC A0A0F5I0K3.1
#=GS F5LH99_9BACL/3-45       AC F5LH99.1
#=GS E3E6Q9_PAEPS/1-42       AC E3E6Q9.1
#=GS C0ZBR5_BREBN/1-43       AC C0ZBR5.1
#=GS A0A0F5HYB6_9BACI/1-49   AC A0A0F5HYB6.1
#=GS C5D4W5_GEOSW/1-45       AC C5D4W5.1
#=GS A0A089MXJ7_9BACL/1-44   AC A0A089MXJ7.1
#=GS A0A0A8JI64_BACSX/1-44   AC A0A0A8JI64.1
#=GS F5LQP6_9BACL/1-45       AC F5LQP6.1
#=GS Q65H31_BACLD/1-45       AC Q65H31.1
#=GS A0A024QCC4_9BACI/1-45   AC A0A024QCC4.1
#=GS A0A0D5NLH2_9BACL/1-44   AC A0A0D5NLH2.1
#=GS A0A075JLD2_9BACI/1-44   AC A0A075JLD2.1
#=GS A0A075JR77_9BACI/1-44   AC A0A075JR77.1
#=GS I0JP72_HALH3/6-48       AC I0JP72.1
#=GS D3FUR2_BACPE/1-45       AC D3FUR2.1
#=GS H6NC34_9BACL/1-44       AC H6NC34.1
#=GS I3E8K1_BACMT/1-44       AC I3E8K1.1
#=GS Q5WIV5_BACSK/1-45       AC Q5WIV5.1
#=GS I0JSP1_HALH3/3-46       AC I0JSP1.1
#=GS A0A0F5ICD4_9BACI/1-43   AC A0A0F5ICD4.1
#=GS Q81LP8_BACAN/1-41       AC Q81LP8.1
#=GS A0A060M0F5_9BACI/1-45   AC A0A060M0F5.1
#=GS A0A0B5AQB5_9BACL/1-46   AC A0A0B5AQB5.1
#=GS N0B0F1_9BACI/1-45       AC N0B0F1.1
#=GS SDA_BACSU/7-51          AC Q7WY62.1
#=GS SDA_BACSU/7-51          DR PDB; 3FYR B; 1-37;
#=GS SDA_BACSU/7-51          DR PDB; 1PV0 A; 1-45;
#=GS SDA_BACSU/7-51          DR PDB; 3FYR C; 1-41;
#=GS SDA_BACSU/7-51          DR PDB; 3FYR A; 1-38;
#=GS U5LHY0_9BACI/1-48       AC U5LHY0.1
#=GS U5LCL3_9BACI/1-45       AC U5LCL3.1
#=GS Q9KD96_BACHD/1-45       AC Q9KD96.1
#=GS L0EIL2_THECK/24-69      AC L0EIL2.1
#=GS A0A0D3VG33_9BACL/44-85  AC A0A0D3VG33.1
#=GS C6CZS6_PAESJ/1-44       AC C6CZS6.1
#=GS A0A024P6L1_9BACI/6-50   AC A0A024P6L1.1
#=GS X5A4Q5_9BACL/1-48       AC X5A4Q5.1
#=GS D3FXI4_BACPE/1-45       AC D3FXI4.1
#=GS A0A0C2YCC0_BACBA/1-43   AC A0A0C2YCC0.1
#=GS D3FQ39_BACPE/12-53      AC D3FQ39.1
#=GS G2TNF5_BACCO/1-45       AC G2TNF5.1
#=GS B7GKA3_ANOFW/14-58      AC B7GKA3.1
#=GS A0A089LZ77_9BACL/1-37   AC A0A089LZ77.1
#=GS D3FXS1_BACPE/1-43       AC D3FXS1.1
#=GS A0A0D5NJD1_9BACL/50-94  AC A0A0D5NJD1.1
#=GS K0J3Q9_AMPXN/1-45       AC K0J3Q9.1
#=GS N0AWJ6_9BACI/1-45       AC N0AWJ6.1
#=GS A7GT31_BACCN/1-50       AC A7GT31.1
#=GS Q9K7P9_BACHD/1-45       AC Q9K7P9.1
#=GS A0A077J272_9BACI/1-45   AC A0A077J272.1
#=GS A0A060LY94_9BACI/3-45   AC A0A060LY94.1
#=GS A0A077J6B6_9BACI/1-43   AC A0A077J6B6.1
#=GS E6TUS7_BACCJ/1-44       AC E6TUS7.1
#=GS A0A0F5I568_9BACI/1-45   AC A0A0F5I568.1
#=GS A0A0B5AN76_9BACL/1-37   AC A0A0B5AN76.1
#=GS Q8EPU6_OCEIH/1-45       AC Q8EPU6.1
#=GS X4ZNQ8_9BACL/14-57      AC X4ZNQ8.1
#=GS A0A060LWX4_9BACI/1-43   AC A0A060LWX4.1
#=GS D3EHJ0_GEOS4/1-41       AC D3EHJ0.1
#=GS Q5KWX4_GEOKA/1-45       AC Q5KWX4.1
#=GS A0A0D3V6R5_9BACL/22-65  AC A0A0D3V6R5.1
#=GS X4ZK35_9BACL/2-39       AC X4ZK35.1
#=GS Q9KCW7_BACHD/1-44       AC Q9KCW7.1
#=GS A0A060LWS0_9BACI/1-46   AC A0A060LWS0.1
#=GS A0A0A2TUK6_9BACL/1-42   AC A0A0A2TUK6.1
#=GS V9WAL0_9BACL/1-45       AC V9WAL0.1
#=GS A0A075LLQ4_9BACI/1-45   AC A0A075LLQ4.1
#=GS A0A089MC80_9BACL/14-57  AC A0A089MC80.1
#=GS U5LCR6_9BACI/1-42       AC U5LCR6.1
#=GS V9W1C9_9BACL/4-47       AC V9W1C9.1
#=GS Q9KDA9_BACHD/1-45       AC Q9KDA9.1
#=GS A0A075R350_BRELA/1-43   AC A0A075R350.1
#=GS A0A0C2TU55_BACBA/1-44   AC A0A0C2TU55.1
#=GS A8FFF6_BACP2/1-45       AC A8FFF6.1
#=GS Q818C7_BACCR/6-50       AC Q818C7.1
#=GS A0A075JMT6_9BACI/1-45   AC A0A075JMT6.1
#=GS A0A060LPZ5_9BACI/1-46   AC A0A060LPZ5.1
I3EAR3_BACMT/1-45                  .......MHR...LSDELLIESYYKALELN....LSQDFIRLIEKEIKRRSLSHKIKV-s......
D5DMR5_BACMD/1-45                  .......MRK...LSDELLIESYSKATELQ....LSPDFIKLIEEEIERRSLKISIQ--ip.....
C2X2V4_BACCE/1-45                  .......MEQ...LSTELLTESYYKAKELK....LNPDFILLIKQEIIRRSLEDKLA--ks.....
E6TW06_BACCJ/7-51                  .......MRY...LSDDLLMETYRKARELQ....LSEDFITLIRQEIERRSRKDKQSI-t......
L0EGN8_THECK/1-42                  .......MNK...LPDELLLEAYYTAVEQK....LDPAFIRMLAAELSRRKLK------pvs....
K0J3Q8_AMPXN/1-40                  .......MNS...LSNELLVEAYLKAVELG....LDSAFISLLWCELSSRKI-------yl.....
A0A0F5I0K3_9BACI/1-42              .......MKI...MSNEMLVAAYRDAKSKG....QDADWIRMLQSEVQKRGLN------lpk....
F5LH99_9BACL/3-45                  kksavel---...LSDYQLLDCFVQALQMK....LGAEFLQQLASEIRRRNL-------y......
E3E6Q9_PAEPS/1-42                  .......--M...LTDEMLLDSYQMAIELK....LECDFIALLLAEIHKRNLEMN----tav....
C0ZBR5_BREBN/1-43                  .......MKY...LSDQMLIEVYHRAVDLQ....LDAAFIELLREELQHRNIRI-----tqf....
A0A0F5HYB6_9BACI/1-49              .......MYQ...LSDEMLLSAYQKAKELDkenkMPRDFITMMEEELKKRNLSVYAN--ns.....
C5D4W5_GEOSW/1-45                  .......MKH...LSDELLIESYYKAKELK....LSPEFIELIEKEIHRRSLGHKIKL-s......
A0A089MXJ7_9BACL/1-44              .......MVE...LSDEMLLDSYHRAIELQ....LEHDFIALLLVEIRKRNLHSP----vha....
A0A0A8JI64_BACSX/1-44              .......MIQ...LSNDLLIESYIKAKNIK....LHPDFIEMLENEMRRRSL-------ltvpss.
F5LQP6_9BACL/1-45                  .......MRQ...ISDETLVESYFKALDLE....LESEFVDLLLGEINRRHI-------vleayhs
Q65H31_BACLD/1-45                  .......MKK...LSDELLIESYIKANEMN....LNREFIELIETEIKRRSLGHLLSV-s......
A0A024QCC4_9BACI/1-45              .......MEH...LSDELLLESYFTANELN....LSPDFLSLIEEEIHRRRLSHKIKN-t......
A0A0D5NLH2_9BACL/1-44              .......MEL...LSDELLVETYLAAVQFN....LDPEFIEMLIGELKRRQIN------pdkir..
A0A075JLD2_9BACI/1-44              .......MWR...LTDELLVESYMRAKSLG....LDKDFVALLEDELNHRNIFIQ----yik....
A0A075JR77_9BACI/1-44              .......MQL...LTDKQLVDAYKKASELH....LDKDFLYLLEREITRRQFN------lmwny..
I0JP72_HALH3/6-48                  ......i-KQ...LSDSLLIQSYHKAIELN....LSEDFILQMREELIARSINM-----dnl....
D3FUR2_BACPE/1-45                  .......MHS...LSDDVLIQSYYRAQEYG....LDDDFLDLLFRELCKRNLQHLASQ-l......
H6NC34_9BACL/1-44                  .......MKL...ISNEILVDSYFKAISLK....LEDEFVELLLEEIQRREIKL-----dyyk...
I3E8K1_BACMT/1-44                  .......MKI...MSNELLIVSYRDALKSD....KDKEWAKILKDEIKRRGLK------pfkkr..
Q5WIV5_BACSK/1-45                  .......MKT...LSDNILIEACKNAIKLN....LDPDFIHLLLKECQRRNISISHH--ln.....
I0JSP1_HALH3/3-46                  ......v-KK...LSHRLLIHSLHTAVEMK....LDHSFIHLLEDELQKRK--------qektysa
A0A0F5ICD4_9BACI/1-43              .......MNQ...MSDDLLLEAYMKARELG....LNAEFISLIEKELKRRSLY------pkay...
Q81LP8_BACAN/1-41                  ..meqls---...------TESYYKAKELK....LNPDFILLIKQEIIRRSLEDKLV--ks.....
A0A060M0F5_9BACI/1-45              .......MEQ...LSDELLIETYRKALDLN....LNQDFIDLIYKELYKRSLHDRVK--lt.....
A0A0B5AQB5_9BACL/1-46              ....mdtMGH...LSYEKLLEALESAKKLN....LAKDFIQLLEREAEKRGLRA-----llc....
N0B0F1_9BACI/1-45                  .......MSSlviLSDQDLLDVFVKAKKYQ....LEVMFIDTLLTEIERRGLN------vva....
SDA_BACSU/7-51                     .......MRK...LSDELLIESYFKATEMN....LNRDFIELIENEIKRRSLGHIISV-s......
#=GR SDA_BACSU/7-51          SS    .......HHH...HHHHHTT--HHHHHHHH....HCT-TTTTTXXXXXXXXXXXXXXX-X......
U5LHY0_9BACI/1-48                  .......MSSlllLSDENLFKVFEDALLCD....VDTDFIRLIADEINRRQLSHLLPV-a......
U5LCL3_9BACI/1-45                  .......MRK...LSDELLIESYFKARELN....LSPDFIRLIETEIHRRSLTHKIRV-s......
Q9KD96_BACHD/1-45                  .......MKT...LSDDLLIETYHKAIELD....LGDDFIGLIKEEIERRSLTEKLKL-t......
L0EIL2_THECK/24-69                 ..illrp---...LTDEHLLEVYHEAVAMG....LSAEFIQLIEEAIRSRNLDPKT---sl.....
A0A0D3VG33_9BACL/44-85             ......l-ES...LNDQQLLNVYELAVQAE....TSTDFIEILEETLEKRHINF-----rk.....
C6CZS6_PAESJ/1-44                  .......MDL...LSDELLEDTYLAAIQYK....LEDDFIRMLLIEMKRRQLNK-----aaas...
A0A024P6L1_9BACI/6-50              .......MKQ...LSDSLLIQSYHKAIELN....LSEEFIDQIKKEINHRSIQHLLE--kh.....
X5A4Q5_9BACL/1-48                  ..mnvvv--E...LSDEMLLDSYHKAIELQ....LEHDFIALLLVEILKRNLHSPHH--av.....
D3FXI4_BACPE/1-45                  .......MNN...LSDELLIETYYKAIELD....LSPDFIELIRIEISRRSLSDKIKL-s......
A0A0C2YCC0_BACBA/1-43              .......MKI...MSNEMLVAAYRDAKNKG....QDTDWIKMLQNEVQKRGLNVT----kn.....
D3FQ39_BACPE/12-53                 ......f-EN...FSDDFLLEAHHMSLKKG....LDHTFISLLEEELEIRGI-------hkdd...
G2TNF5_BACCO/1-45                  .......MYK...LSDELLIESYYKAKELK....LSAEFVKLIEKEIERRSLTHKIKA-t......
B7GKA3_ANOFW/14-58                 .......MKC...LPDDLLIESYYKAKELQ....LSKEFIQLIEREIFRRRLHHKLKQ-t......
A0A089LZ77_9BACL/1-37              .......---...----MLLDSYHKAIELQ....LEHDFIALLLVEILKRNLHSPE---da.....
D3FXS1_BACPE/1-43                  .......MEQ...IRNDILIDAYLKAIELE....LDLEFLELLYQELQTRELE------qfvs...
A0A0D5NJD1_9BACL/50-94             ..mllqp---...LNDEHLLEVYEEAKQLR....LSEEFIELIEQTLEQRNLR------saym...
K0J3Q9_AMPXN/1-45                  .......MDK...LTNELLLECYEKAVELN....LDEAFIRLIEQEIYSRSLTHMIS--gf.....
N0AWJ6_9BACI/1-45                  .......MKK...LTDDLLIEAYYKARELK....LNPDFIRLIEKELQRRALFLKIKV-s......
A7GT31_BACCN/1-50                  .mntnhi-EQ...LSTELLTESYYKAKELK....LNPDFILLIKQEIIRRSLEDKLV--ks.....
Q9K7P9_BACHD/1-45                  .......MDN...IHDDVLIEAYVRAKELN....LKQDFIELLMNEMVRRCLPFQEE--gi.....
A0A077J272_9BACI/1-45              .......MRR...LSDELLIESYFKARELN....LSPEFISLIESEIRRRSLITKIKK-s......
A0A060LY94_9BACI/3-45              ......l-KS...LPNQCLLEAYTHALTLA....LPEDFILILKKEILLR---------mqsnnqn
A0A077J6B6_9BACI/1-43              .......MKI...MSNEQLVVSYRDALKSG....KEKEWIRILKDEIERRGLKA-----ikk....
E6TUS7_BACCJ/1-44                  .......MKK...LNDESLIEAYIKSMEIN....VSQHFIDLLEEELKERGLFDK----vis....
A0A0F5I568_9BACI/1-45              .......MRQ...LTDELLLLSYEKAVDYS....LEEEFIHLLENEIEQRGLAD-----rliel..
A0A0B5AN76_9BACL/1-37              .......MDK...LSLEALIMAYEAAKEKE....LSEDFLQLLETEILK----------ke.....
Q8EPU6_OCEIH/1-45                  .......MEN...LSDELLLESYYTACELQ....LSPDFLSLFEEEIHKRCLSHKIKN-t......
X4ZNQ8_9BACL/14-57                 ......l-EM...LTNEQLLNIYELAVQAK....ASPEFIEIIEEVLSKRSLEHSEH--l......
A0A060LWX4_9BACI/1-43              ....mlq--Q...LNDQLLIEACELAEERN....LNRDFVDILKEELERRGLGV-----ss.....
D3EHJ0_GEOS4/1-41                  .......--M...LTDEMLLDSYHMAVELK....LEREFITLLLAEIHKRNLDT-----dsg....
Q5KWX4_GEOKA/1-45                  .......MKH...LSDELLIESYFKAKELN....LSPEFIELIEKEIQRRSLTHKIKL-s......
A0A0D3V6R5_9BACL/22-65             .......MAI...LSDEMLLESYYLAIDLK....LEHDFITLLLAEIHKRRLQFQQ---li.....
X4ZK35_9BACL/2-39                  ......v---...-----ILEAYQDAVKLG....LSYDFIQLLKEELNRRGINT-----nltee..
Q9KCW7_BACHD/1-44                  .......MK-...LSDQQLLEAYDQALKLE....LEDDFISVLKEEMIKRNLEVDKD--ie.....
A0A060LWS0_9BACI/1-46              .....mi-EQ...LSDSVLLEAYNKAKQIQ....LEEDFLAILEKELVRRDIHINKS--tm.....
A0A0A2TUK6_9BACL/1-42              .......--M...LSDEMLLDSYHKAIELD....LERDFIALLLAEIHKRKLGTD----vsa....
V9WAL0_9BACL/1-45                  .......MRV...ISDETLLESYWKALDLQ....LDVDFVNLLLMEIKRRDLSVENK--as.....
A0A075LLQ4_9BACI/1-45              .......MEH...LSDELLIESYHKANELH....LSQEFIHLIEKEIQSRGLSHKIR--yt.....
A0A089MC80_9BACL/14-57             .....le--L...LSDEQLLNIYDLAVEAK....ASPDFIEIIQTVLTERNISS-----pnrs...
U5LCR6_9BACI/1-42                  .......MKI...MSNEQLVVSYRDALKTG....MEKEWINILKGEIQRRGL-------rpfk...
V9W1C9_9BACL/4-47                  yknallv---...LNDQQLKECYTQALRLR....LSSEFLKQLGAELKRRNL-------ca.....
Q9KDA9_BACHD/1-45                  .......MET...LSDTFLMEACKYAIKLN....LDPDFIHILIEECERRSLPIPEN--dl.....
A0A075R350_BRELA/1-43              .......MRY...LSDTMLIEVYQRAVALH....LDADFIFLVEAEMARRKLSFQ----sa.....
A0A0C2TU55_BACBA/1-44              .......MHR...ISDDVLLEAYAKARKLD....LSRDFILLIEDELKKRALYFQ----vqa....
A8FFF6_BACP2/1-45                  .......MKK...LSDDLLIESYYKANEMN....LNRDFIELIETEMKRRSLGHMLSV-s......
Q818C7_BACCR/6-50                  .......MEQ...LSTELLTESYYKAKELK....LNPDFILLIKQEIIRRSLEDKLV--ks.....
A0A075JMT6_9BACI/1-45              .......MEQ...LSDELLLESYYTAYELD....LSADFLSLIEEEIQRRHLSHKLK--tk.....
A0A060LPZ5_9BACI/1-46              .....ml-QQ...LSDDLLLEAYDRAIQHC....LNADFISIIKQELRRRGLLKHIH--mk.....
#=GC SS_cons                       .......HHH...HHHHHTT--HHHHHHHH....HCT-TTTTTXXXXXXXXXXXXXXX-X......
#=GC seq_cons                      .......Mcp...LSDEhLlEuYh+Ah-Lp....LstDFIpLlcpElp+RsLp......s......
//
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