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Database: Pfam
Entry: SelP_N
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Original site: SelP_N 
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#=GF ID   SelP_N
#=GF AC   PF04592.9
#=GF DE   Selenoprotein P, N terminal region
#=GF AU   Kerrison ND
#=GF SE   DOMO:DM04433;
#=GF GA   22.90 22.90;
#=GF TC   23.40 23.30;
#=GF NC   22.80 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10775431
#=GF RT   Selenoprotein P: properties, functions, and regulation. 
#=GF RA   Mostert V; 
#=GF RL   Arch Biochem Biophys 2000;376:433-438.
#=GF RN   [2]
#=GF RM   11168591
#=GF RT   Selenium metabolism in zebrafish: multiplicity of selenoprotein
#=GF RT   genes and expression of a protein containing 17 selenocysteine
#=GF RT   residues. 
#=GF RA   Kryukov GV, Gladyshev VN; 
#=GF RL   Genes Cells 2000;5:1049-1060.
#=GF RN   [3]
#=GF RM   9358058
#=GF RT   Analysis of bovine selenoprotein P-like protein gene and
#=GF RT   availability of metal responsive element (MRE) located in its
#=GF RT   promoter. 
#=GF RA   Fujii M, Saijoh K, Kobayashi T, Fujii S, Lee MJ, Sumino K; 
#=GF RL   Gene 1997;199:211-217.
#=GF DR   INTERPRO; IPR007671;
#=GF CC   SelP is the only known eukaryotic selenoprotein that contains
#=GF CC   multiple selenocysteine (Sec) residues, and accounts for more
#=GF CC   than 50% of the selenium content of rat and human plasma [1]. 
#=GF CC   It is thought to be glycosylated [2].  SelP may have antioxidant
#=GF CC   properties.  It can attach to epithelial cells, and may protect
#=GF CC   vascular endothelial cells against peroxynitrite toxicity [1].
#=GF CC   The high selenium content of SelP suggests that it may be
#=GF CC   involved in selenium intercellular transport or storage [2]. The
#=GF CC   promoter structure of bovine SelP suggest that it may be
#=GF CC   involved in countering heavy metal intoxication, and may also
#=GF CC   have a developmental function [3]. The N-terminal region of SelP
#=GF CC   can exist independently of the C terminal region.  Zebrafish
#=GF CC   selenoprotein Pb (Swiss:Q98SV0) lacks the C terminal Sec-rich
#=GF CC   region, and a protein encoded by the rat SelP gene and lacking
#=GF CC   this region has also been reported [2]. N-terminal region
#=GF CC   contains a conserved SecxxCys motif, which is similar to the
#=GF CC   CysxxCys found in thioredoxins.  It is speculated that the N
#=GF CC   terminal region may adopt a thioredoxin fold and catalyse redox
#=GF CC   reactions [2]. The N-terminal region also contains a His-rich
#=GF CC   region, which is thought to mediate heparin binding.	Binding to
#=GF CC   heparan proteoglycans could account for the membrane binding
#=GF CC   properties of SelP [1].  The function of the bacterial members
#=GF CC   of this family is uncharcterised.
#=GF SQ   83
#=GS D6REX5_HUMAN/22-250   AC D6REX5.1
#=GS D2XNK7_SACKO/23-275   AC D2XNK7.1
#=GS H2MB78_ORYLA/1-161    AC H2MB78.1
#=GS E9QB63_DANRE/22-253   AC E9QB63.1
#=GS F7EK34_ORNAN/11-166   AC F7EK34.1
#=GS G3NUN5_GASAC/1-213    AC G3NUN5.1
#=GS A1E951_PIG/22-256     AC A1E951.3
#=GS H0ZC10_TAEGU/1-47     AC H0ZC10.1
#=GS F1C7F1_PERFV/1-101    AC F1C7F1.1
#=GS A6FZW7_9DELT/139-264  AC A6FZW7.1
#=GS F1RD74_DANRE/27-264   AC F1RD74.1
#=GS H2SF16_TAKRU/1-110    AC H2SF16.1
#=GS SEPP1_PONAB/22-250    AC Q5R8W9.2
#=GS G3PMU8_GASAC/1-190    AC G3PMU8.1
#=GS H3DGX7_TETNG/22-283   AC H3DGX7.1
#=GS G3ID68_CRIGR/26-164   AC G3ID68.1
#=GS G3W9K6_SARHA/22-176   AC G3W9K6.1
#=GS H1A5G2_TAEGU/1-124    AC H1A5G2.1
#=GS G3TLW1_LOXAF/22-207   AC G3TLW1.1
#=GS G1KQP6_ANOCA/25-179   AC G1KQP6.1
#=GS F6V1E8_ORNAN/22-210   AC F6V1E8.1
#=GS Q9BDE5_BOVIN/1-137    AC Q9BDE5.1
#=GS B0W3C3_CULQU/141-297  AC B0W3C3.1
#=GS A9JRW5_DANRE/22-253   AC A9JRW5.2
#=GS G1KY65_ANOCA/22-58    AC G1KY65.1
#=GS D6RIS9_HUMAN/22-209   AC D6RIS9.1
#=GS H9HQK8_ATTCE/40-289   AC H9HQK8.1
#=GS SELPA_DANRE/22-253    AC Q98SV1.3
#=GS H6WVW6_CAPHI/22-237   AC H6WVW6.1
#=GS F1NCT1_CHICK/26-262   AC F1NCT1.1
#=GS Q5PR33_DANRE/27-265   AC Q5PR33.2
#=GS Q9BDE3_BOVIN/1-121    AC Q9BDE3.1
#=GS Q9BDE2_BOVIN/1-119    AC Q9BDE2.1
#=GS G1LAZ4_AILME/3-242    AC G1LAZ4.1
#=GS E3X2N3_ANODA/520-676  AC E3X2N3.1
#=GS G3UU18_MELGA/1-163    AC G3UU18.1
#=GS E5SI43_TRISP/46-254   AC E5SI43.1
#=GS E0CZC5_MOUSE/22-177   AC E0CZC5.1
#=GS G3WG53_SARHA/1-206    AC G3WG53.1
#=GS H3CE96_TETNG/5-135    AC H3CE96.1
#=GS F1M9W3_RAT/22-252     AC F1M9W3.1
#=GS A2I5C2_MYTGA/1-97     AC A2I5C2.1
#=GS Q4RPX4_TETNG/1-185    AC Q4RPX4.1
#=GS H0UZB3_CAVPO/1-136    AC H0UZB3.1
#=GS H2UNP3_TAKRU/22-266   AC H2UNP3.1
#=GS C3YH40_BRAFL/68-190   AC C3YH40.1
#=GS H3F8E2_PRIPA/108-245  AC H3F8E2.1
#=GS Q9BDE4_BOVIN/1-129    AC Q9BDE4.1
#=GS A6GDZ9_9DELT/130-247  AC A6GDZ9.1
#=GS A8Q424_BRUMA/14-218   AC A8Q424.1
#=GS SEPP1_HUMAN/22-250    AC P49908.3
#=GS F4X476_ACREC/858-977  AC F4X476.1
#=GS G1Q9G6_MYOLU/22-202   AC G1Q9G6.1
#=GS H2ZVW4_LATCH/22-227   AC H2ZVW4.1
#=GS H9KP47_APIME/88-182   AC H9KP47.1
#=GS F6Q9N1_XENTR/22-205   AC F6Q9N1.1
#=GS Q16FG7_AEDAE/101-252  AC Q16FG7.1
#=GS B7Q2F3_IXOSC/1-124    AC B7Q2F3.1
#=GS F6V1F5_ORNAN/22-251   AC F6V1F5.1
#=GS G5APA7_HETGA/51-234   AC G5APA7.1
#=GS G9KN32_MUSPF/1-156    AC G9KN32.1
#=GS SEPP1_BOVIN/22-267    AC P49907.2
#=GS Q7Q0I7_ANOGA/145-295  AC Q7Q0I7.4
#=GS SELPB_DANRE/27-265    AC Q98SV0.3
#=GS F6PUF8_HORSE/22-252   AC F6PUF8.1
#=GS E1FTD5_LOALO/3-160    AC E1FTD5.1
#=GS H3DJR4_TETNG/1-205    AC H3DJR4.1
#=GS A7RTX8_NEMVE/22-189   AC A7RTX8.1
#=GS E0CZ76_MOUSE/22-124   AC E0CZ76.1
#=GS F6VJE4_XENTR/24-265   AC F6VJE4.1
#=GS E2AE76_CAMFO/127-281  AC E2AE76.1
#=GS H2PXQ5_PONAB/22-250   AC H2PXQ5.1
#=GS Q6DJ72_XENTR/12-253   AC Q6DJ72.1
#=GS B5DDI2_DANRE/1-174    AC B5DDI2.1
#=GS F1N9T1_CHICK/1-128    AC F1N9T1.1
#=GS E0CX80_MOUSE/22-139   AC E0CX80.1
#=GS F4X476_ACREC/84-323   AC F4X476.1
#=GS SEPP1_MOUSE/22-248    AC P70274.3
#=GS Q9N0N7_CAPHI/22-205   AC Q9N0N7.1
#=GS SEPP1_RAT/22-253      AC P25236.2
#=GS E0CY03_MOUSE/32-110   AC E0CY03.1
#=GS H3J6C3_STRPU/83-213   AC H3J6C3.1
#=GS Q6P3K0_DANRE/22-253   AC Q6P3K0.2
D6REX5_HUMAN/22-250              ..........................................QDQSSLCKQPPAWSIRD.QDPMLNSNG..SVTVVALLQA.S...CYLCILQA.SKLEDLRVKLKKE....GYSNISYIVVN....HQGIS.SR............L............KYTHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPFS....FL...TFPYVEEAIKIAYCEKKCGNCS...LT.T...L........K...D.....EDFCKRVSL...................ATVDKT.VET----...--P.SP....HYH..---.--HEHHH..NHG.HQHLG.....SSELSENQ.QPG..aPNAPTH.PA.pPGL.HHHHKHK...................................................................
D2XNK7_SACKO/23-275              .......................................isp-----ECPDGVLWSVNE.ETPMLANRG..KVVVVALLQA.S...UHFCLSQA.EALEVLREKFLSQ....GMDEISFLVVN....SKKLH.SQ............F............LIGHLHQ.......RVS-.....-F.......PVYQ...A-RYENDIWSQLDGA...KDDIIVYD..RCGKLV..DHIRMPYS....FL...ENDNVERAIVSAYYENPCGRCE...VV.EpqvS........E...D.....LVTYEVNTSyegsgdiidgdplvylielE-----.-------...---.--....HEV..EDL.EKQALER..QRV.RNHSQ.....TNSSDESQ.MVG...QDEKNS.ES..---.-------mesredksgsasseeskkygstesk..........................................
H2MB78_ORYLA/1-161               ..........................................-----------------.---------..----------.-...--------.-------------....-------MIVN....ELEAL.SQ............T............MHWKLKK.......KAPT.....GV.......PVYQ...QSSLQKDVWEILDGD...KDDFLIYD..RCGLLT..FHIVLPNS....FL...QNADVENAITATYTQDIC-NCS...GN.S...T........L...Sg..ggNNFTRNSSQshsgvq.......rpadepENVTTT.LEASPND...SRH.EH...aHHH..HPH.HQHL--H..HHH.PHHQH.....--------.---...------.--..---.-------lhhh...............................................................
E9QB63_DANRE/22-253              .........................................e-TEGARCKLPPEWKVGD.VEPMKNALG..QVTVVAYLQA.S...CLFCLEQA.SKLNDLLLKLEKQ....GYPNIAYMVVN....NREER.SQ............R............LHHLLQE.......RLL-.....NI.......TLYA...QDLSQPDAWQAVNAE...KDDILVYD..RCGRLT..YHLSLPYT....IL...IHPHVEEAIKHTYCDRICGECS...LE.S...S........A...Q.....LEECKKAT-...................EEVNKP.VEEEPRQ...DHG.HH...eQGH..HEH.QGEAERH..RHG.HHHPH.....HHHHHHRG.QQQ...VD----.--..---.-------vdqqvlsqvdf........................................................
F7EK34_ORNAN/11-166              .........................................e-NGTRICQPAPRWTVNG.VAPMEGTEG..QVIVVALLKA.R...SFFCALPS.AYLAGLRERLAGH....GAGNVSFLIVN....QRDPT.AQ............L............LHTELER.......HAPP.....GV.......PVYA...QDGPDPDVWSVLGGD...KDDFFVYD..RCGRLT..FHIQLPFS....FL...HFPYVEAAVRFTHRRDFCGNCS...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------y..................................................................
G3NUN5_GASAC/1-213               ..........................................-----------------.---------..----------.-...--------.--MDGLRQKLESQ....GLKDVAYMVVN....QQGEQ.AR............R............LHPMLAQ.......RLSV.....NI.......DLYK...QDEQQPDVWKTLGGD...KDDFLVYD..RCGRLT..HHIALPYS....II...GQGHVESAIKDAYCKRTCGDCV...HE.S...A........T...T.....PEECVEKAVa.................qPDADAPpVVEDNGG...GGG.HHghhhHGH..GHH.RGHHHGH..HHG.HHHGG.....--DHGAGQ.QAV...VHQEHE.RD.gGAS.HGQH---nsaldqmqqqahipqmphg................................................
A1E951_PIG/22-256                ..........................................QGKSSFCEQPPGWSIKD.QDPMLNSYG..SVTVVALLQA.S...UYLCILQA.SRLEDLRVKLEKE....GYSNISYIVVN....HQGIA.SQ............L............KYVYLKS.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGN...KDDFLIYD..RCGLLV..YHLGLPYS....FL...TFPYVEEAIKTVYCENKCGNCS...LK.T...L........K...D.....EDFCKNVYL...................ATEEKT.TEAPQPH...HHH.DH....HHH..---.--RHHHH..HHG.HQHLG.....NGHLSEHP.KPE..aPDAPEQ.PP.pSGL.HHHHGHK...................................................................
H0ZC10_TAEGU/1-47                ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLVYD..RCGRLA..FHIQLPFS....FL...HFPYVEAAIRSSHIKDFCGNCS...L-.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
F1C7F1_PERFV/1-101               .........................................l-----------------.---------..----------.-...--FCLVQA.SRMDDLRQKLEDQ....GLKDVVYMVVN....QQAEQ.AR............R............LHTMLAQ.......RMSE.....NI.......TLYK...QDEQQPDVWKTLSGQ...KDDFLIYD..RCGRLT..YHISLPYS....II...GHGHVE----------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
A6FZW7_9DELT/139-264             .................ecapiwdlydfqpqscgytetygld-----------------.-----SFEG..HVTLIAMLAG.W...CSYCQSQA.GKMEEMRLELALE....GY-DVQMIAIN....ATSAD.ND............D............DRQNLVD.......RCA-.....-F.......PLF-...QDIDEVDAWDLHGGT...KDDLVIYH..ADGTM-..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------avfld..............................................................
F1RD74_DANRE/27-264              ........................................ss--GSRICKPAPQWEIDG.KTPMKELLG..NVVVVALLKA.S...CHFCLTQA.ARLGDLRDKLANG....GLTNISFMVVN....EQDSQ.SR............A............MYWELKR.......RTAQ.....DI.......PVYQ...QSPLQNDVWEILEGD...KDDFLVYD..RCGYLT..FHIVLPFS....FL...HYPYIEAAIRATYHKNMC-NCS...LN.A...N........F...S.....ISESSDSTKne..............pagENNQRP.NSTEPVT...--A.AH....HHH..---.--HQQHE..PHH.HHNPY.....PNNHKKSG.DSD..vTGKPKE.PT.hHSHqEHVHNHR...................................................................
H2SF16_TAKRU/1-110               ..........................................-----------------.---------..----------.-...--------.-RIGGLRKKLIQS....NMTEVSYMIVN....EQDPH.SR............A............LFWELER.......RAPP.....DV.......PVYQ...QSAFQSDVWETLDGD...KDDFLIYD..RCGQLT..FHVGLPYS....FL...NYVYVEAAIRATYQGNIC-NCS...V-.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------s..................................................................
SEPP1_PONAB/22-250               ..........................................QDQSSLCKQPPAWSIRD.QGPMLNSNG..SVTVVALLQA.S...UYLCILQA.SKLEDLRVKLKKE....GYSNISHIVVN....HQGIS.SR............L............KYTHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPFS....FL...TFPYVEEAVKIAYCEKKCGYCS...LT.T...L........K...D.....EDFCKSVSL...................ATVDKT.VEA----...--P.SP....HYH..---.--HEHHH..NHR.HQHLG.....SSELSENQ.QPG..aPDAPTH.PA.pPGL.HHHHKHK...................................................................
G3PMU8_GASAC/1-190               ..........................................-----------------.---------..----------.-...--------.-------------....-------MIVN....EREPH.SR............A............MYWELKR.......RAPP.....GV.......PVYQ...QAALQSDVWEALDGD...KDDFLVYD..RCGLLT..FHIVLPYS....FL...HNVYVEAAIRATYLKNIC-NCT...VD.S...V........VsslN.....NSVMNNETDfnvsqtn.....atpriqpD-TNDP.EGAGTPP...PPT.HH....HSH..HHH.HHHQHHH..PHH.PHHAH.....LNQPLHD-.-TS...QNITRH.PL..SVH.HHHHPH-hhhqq..............................................................
H3DGX7_TETNG/22-283              ........................................dg--DGPRCQLPPTWKIGD.LEPMTGAMG..RVTVVALLDA.R...STIDFLNL.GRMDSLRQKLENQ....GLRDVVYMVVN....HQGAQ.AR............G............LHAMLAQ.......RLSE.....HI.......SLHR...QDEALADVWQTLGGN...KDDFFIYD..RCGRLT..HRISLPYA....VI...GHGHVEKAVKDTYCSSLCGECT...HE.T...A........E...T.....QQECTPKT-...................--DTQP.QED---T...RHE.CH....HRH..--H.QGHQHHG..DGH.RDHGD.....-NQCTHTQ.GSG...PGHDHG.HGhhGGQ.GHHQ---ghdqaggvaqrpdhlelgqaqqvvsfhhhqhdaa.................................
G3ID68_CRIGR/26-164              ........................................gp-----------------.---------..----------.-...--------.NRLEDLRLKLENQ....GYSNISYIIVN....HQGSP.SQ............L............KHTHLKN.......HVSD.....QI.......AVYR...QEEHQTDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEKKCRNCS...FT.L...L........R...V.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------krrsprrhitttstitntgtg..............................................
G3W9K6_SARHA/22-176              .........................................n-NGTRICQPAPDWQVDGgVSPMEEALG..NVTEVALLKA.P...LTRPFL-A.PRIGSLQERLARA....GTAGVRFLIVN....HKSAA.AQ............A............LQGELEL.......RAPR.....GV.......PVYS...QRGPRPDIWGLLGGA...KDDFLVYD..RCGRLT..FHIQLPFS....AL...SFPFVEAAVRFSHQQDHCGNCS...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
H1A5G2_TAEGU/1-124               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGMPYS....FL...HFQYVEESIKIAYCENKCGNCS...YM.E...P........D...A.....DGVCENITK...................KAVEEL.SEIEPKP...TGQ.HS....HPN..LHR.HGHHQRH..HHH.HHHHK....gSRDPKHENhQAA...AEAERH.HP..---.-------hsg................................................................
G3TLW1_LOXAF/22-207              ..........................................QVQSSFCKQPPAWKIRE.EDPMLNSIG..SVTVVALLQA.Sr.kNYTCLQRT.CQLEDLRVKLEKE....GYSNVSYVIVN....HQDLN.SR............L............KYIHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEAAIKIVYCEEKCGNCS...LM.T...P........E...D.....EDFCKKVSS...................VNVEDT.AEASKP-...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------hh.................................................................
G1KQP6_ANOCA/25-179              .........................................e-NKTRICQPAPLWKING.TAPMAGMEG..QVTVVALLKA.S...MLVISLPA.ISIGGLQKKLSNE....GVANVSFLIVN....EKTPL.SR............A............MYWELKR.......NAPQ.....GI.......PVYQ...QQILEPDVWQILDGD...KDDFLIYD..RCSRLT..FHIQLPYS....FL...HLPYVEAAVHYTHRKDYCGNCS...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
F6V1E8_ORNAN/22-210              ..........................................QSASSHCKEAPRWQIRD.QDPMLNSLG..TVTVVALLQA.SsiiCIFFLLKP.FRLEDLRVKLENE....GYSNISYIIVN....HQGMP.SQ............L............NHKTLKE.......KVSE.....HI.......PVYQ...QDEKQTDVWSTLKGN...KDDFLIYDrsRCGRLV..YHLSLPYT....FL...SFSYVEDSIKTTYCEQNCGNCS...YT.M...P........E...A.....EEFCTNTSS...................AAKEKA.TEA----...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------plphn..............................................................
Q9BDE5_BOVIN/1-137               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LS.R...P........Q...D.....EDVCKNVFL...................ATKEKT.AEASQRH...HHP.HP....HPH..SHS.HPHPHPH..PHP.HPHHGhqlheNAHLSESP.KPD..tPDTPEN.PP.tSGLhHHHHRHK...................................................................
B0W3C3_CULQU/141-297             ...................................tsiaagy-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....NI.......SVYP...NPLNENGTYAMYGLK...EFQVYVLD..RCSRIA..YIIEPPWS....LI...QYSYVKAAVLSTLYDRPCGECD...VD.N...F........L...N.....SSLPVQKMA...................ELQQMP.TAKSTST...TTT.TT...tTTE..PSS.SSTSAST..PRS.DVRPY.....-DDSTESD.EPM..aTEEYSE.PP..E--.-------pttteevv...........................................................
A9JRW5_DANRE/22-253              .........................................e-TEGARCKLPPEWKVGD.VEPMKNALG..QVTVVAYLQA.S...ULFCLEQA.SKLNDLLLKLENQ....GYPNIAYMVVN....NREER.SQ............R............LHHLLQE.......RLL-.....NI.......TLYA...QDLSQPDAWQAVNAE...KDDILVYD..RCGRLT..YHLSLPYT....IL...SHPHVEEAIKHTYCDRICGECS...LE.S...S........A...Q.....LEECKKAT-...................EEVNKP.VEEEPRQ...DHG.HH...eHGH..HEH.QGEAERH..RHG.HHHPH.....HHHHHHRG.QQQ...VD----.--..---.-------vdqqvlsqvdf........................................................
G1KY65_ANOCA/22-58               .........................................q-GPSTRCKEPPDWRIGE.QNPMLDSRG..FVTVVALLQA.S...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...--------..------..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
D6RIS9_HUMAN/22-209              ..........................................QDQSSLCKQPPAWSIRD.QDPMLNSNG..SVTVVALLQA.S...CYLCILQA.SKLEDLRVKLKKE....GYSNISYIVVN....HQGIS.SR............L............KYTHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPFS....FL...TFPYVEEAIKIAYCEKKCGNCS...LT.T...L........K...D.....EDFCKRVSL...................ATVDKT.VET-PSP...HYH.HE....H--..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
H9HQK8_ATTCE/40-289              ............................eeqdwyfeqcrfvn-----------------.--AWKEHLG..HVSVLAFLDP.A...WQYSFRQA.VMLELLSSRLRKS....DFPDIRFFVISpssdLKDDK.SE............NdleieawreigaKY-EMEN.......FVNS.....DFlknngteIIFL...QDDPQSRIWERFRAS...REHAVIID..RCGKLT..YHVIVPWS....IL...FFPYVKAAILSTYMDDPCGGCNpavYQ.A...S........N...H.....ENHVVELTK...................STKKDL.STKKDSS...YREiDT....KFE..IIW.TTESLPE..NLT.HLHHE.....SSSEEERE.TS-...------.--..---.-------tassilleni.........................................................
SELPA_DANRE/22-253               .........................................e-TEGARCKLPPEWKVGD.VEPMKNALG..QVTVVAYLQA.S...ULFCLEQA.SKLNDLLLKLENQ....GYPNIAYMVVN....NREER.SQ............R............LHHLLQE.......RLL-.....NI.......TLYA...QDLSQPDAWQAVNAE...KDDILVYD..RCGRLT..YHLSLPYT....IL...SHPHVEEAIKHTYCDRICGECS...LE.S...S........A...Q.....LEECKKAT-...................EEVNKP.VEEEPRQ...DHG.HH...eHGH..HEH.QGEAERH..RHG.HHHPH.....HHHHHHRG.QQQ...VD----.--..---.-------vdqqvlsqvdf........................................................
H6WVW6_CAPHI/22-237              ..........................................QGQSSYCKQPPAWSIKD.QDPMLNSYG..SVTVVALLQA.S...UYLCILQA.SRLEDLRVKLEKE....GYSNISYVVVN....HQEIS.SR............L............KYVHPKN.......KVSE.....HI.......PVYQ...QEDDQPDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LK.T...Q........E...D.....EDFCKNVSL...................ATKEKT.AEASRRH...HHH.HR....HKG..HQR.QGHSD--..---.-----.....--------.---...------.--..---.-------ncdtpvgsenlqlslpq..................................................
F1NCT1_CHICK/26-262              .........................................g-TESQRCQEPPEWHIGE.ESPMLNARG..SVAVVALLQA.S...VLFCLLQKlDKLEDLRVKLENE....GLVNISYVVVN....HQSPH.SQ............K............KFHLLQE.......SVSD.....HI.......TVYQ...QDDHQADVWTTLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...SFQYVEEAIKIAYCENNCGNCS...YT.T...T........F...N.....VCVSWAVTKni..............fwgENYSQPgIEPEPEP...SGQ.HS....HHH..---.-HQLHRH..RHH.HHHRE.....GGRHSKTQ.NHQapsESQRRH.P-..---.-------hngr...............................................................
Q5PR33_DANRE/27-265              .........................................s-NGSRICKPAPQWEIDG.KTPMKELLG..NVVVVALLKA.S...UHFCLTQA.ARLGDLRDKLANG....GLTNISFMVVN....EQDSQ.SR............A............MYWELKR.......RTAQ.....DI.......PVYQ...QSPLQNDVWEILEGD...KDDFLVYD..RCGYLT..FHIVLPFS....FL...HYPYIEAAIRATYHKNMC-NCS...LN.A...N........F...S.....ISESPDSTKne..............pagENNQRP.NSTEPVT...--A.AH....HHH..---.--HQQHE..PHH.HHHNP....yPNSHKKSG.DSD..vTGKPKE.PT.hHSHqEHVHNHR...................................................................
Q9BDE3_BOVIN/1-121               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LS.R...P........Q...D.....EDVCKNVFL...................ATKEKT.AEASQRH...HHP.HP....HPH..---.-------..-HG.HQLHE.....NAHLSESP.KPD..tPDTPEN.PP.tSGLhHHHHRHK...................................................................
Q9BDE2_BOVIN/1-119               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LS.R...P........Q...D.....EDVCKNVFL...................ATKEKT.AEASQRH...HHP.HP....H--..---.-------..-HG.HQLHE.....NAHLSESP.KPD..tPDTPEN.PP.tSGLhHHHHRHK...................................................................
G1LAZ4_AILME/3-242               ..........................................QGQSSFCKQPPAWSIRD.QSPMLNSGG..SVTVVALLQA.S...SKYLLGRI.YRLEDLRVKLEKE....GYLNISYVVVN....HQGLP.SQ............L............KYMHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGK...KDDFLVYD..RCGRLV..HHLGLPYS....FL...TFPYVEEAIKIAYCEEKCGNCS...LM.Q...NininsltqE...A.....EDFCKMVSS...................ATVGTT.TEAPPPH...HHH.HH....HHH..---.--HRHHH..KHG.HPHHG.....NDELSEDQ.QPE..aEQAREH.PA.pRGL.HRHH---...................................................................
E3X2N3_ANODA/520-676             ...........................nftefyatvrglade-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......---R.....NL.......TVYP...NPLTENGTFALLGLR...EFQVYVID..RCSRVS..YIIEPPWS....LI...QFSYVKAAVLSTFYDRPCGKCE...FE.N...Y........I...N.....SSISD----...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------edrnpspgakdamagcinghapsctemfeesidnaeedeggmqdseeddedsysytrtkdesd....
G3UU18_MELGA/1-163               ..........................................-----------------.---------..----------.-...--------.-------------....-------MIIN....EQAPL.SR............A............MFGELQR.......HAPP.....GV.......PVLQ...QQPHEPDVWQLLGGD...KDDFLVYD..RCGRLA..FHIQLPYS....FL...HLPYVESAIRFTHRKDFCGNCS...LY.T...N........S...T.....QEANSTMEV...................PTTLTP.LPKQEEK...ESE.T-....---..--P.AHHQPNH..LHP.HHHAV.....----GSRT.APE...PSGDHR.PA..HTH.HHHGAH-g..................................................................
E5SI43_TRISP/46-254              ........................................de---PDICHPVPMFTNGG.QLVMTNYHG..HVTLIALMEL.Q...CTLCRTQI.SSIVKLSELFREN....YDEPTKFLVVA....PHNES.DR............F............VEYYKQY.......LKPY.....DI.......GVIQ...-ETTAEPIWHTLRGS...RFDFFVYD..RCGRLN..YYIPYPQS....FM...YYHYTISSLHSTHRYIKCGPCP...SN.R...Q........Di.sT.....AAVSVGKTL...................TDDGQW.NSNDQRS...TFP.SE....TS-..---.-------..---.-----.....--------.---...------.--..---.-------svykhhlpkyqpkyirgls................................................
E0CZC5_MOUSE/22-177              ..........................................QGQSSACYKAPEWYIGD.QNPMLNSEG..KVTVVALLQA.S...CYLCLLQA.SRLEDLRIKLESQ....GYFNISYIVVN....HQGSP.SQ............L............KHSHLKK.......QVSE.....HI.......AVYR...QEEDGIDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEERCGNCN...L-.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
G3WG53_SARHA/1-206               ..........................................-----------------.---------..----------.-...-YLCILQA.SRLEDLRVKLERE....GFSNISYIVVN....HQGNP.SQ............L............NFKELKD.......KVSE.....NI.......TVYQ...QEVNQQDVWTVLNGS...KDDFLIYD..RCGRLV..YHLGLPYT....FL...TFSYVEEAIKVAYCEKSCGNCS...YT.T...I........D...D.....ESFCKNASS...................VAEEEP.TRT-PTS...HPP.HH....H-L..RHH.HDHHHHH..HHH.QHHRHg..hqPTENKKPE.DSE...TAADVH.SA..QGL.HHHHE--sthqqhr............................................................
H3CE96_TETNG/5-135               qlfmvylrsgmwslliyciywhlklglsdevdnceslhlgqy-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...--------..------..--------....--...----------------LCNEPR...IDeA...T........Q...E.....PENCKDMIA...................WGETRS.RSKNQKThedTHT.HT....HTH..THT.HTHTHTH..THT.HTHQP.....-VNLQLHT.STN...SQAKQH.PA..L--.-------gyrcrt.............................................................
F1M9W3_RAT/22-252                ..........................................QGQSPACKQAPPWNIGD.QNPMLNSXG..TVTVVA-LQA.S...CYLCLLQA.SRLEDLRIKLENQ....GYFNISYIVVN....HQGSP.SQ............L............KHAHLKK.......QVSD.....HI.......AVYR...QDEHQTDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEKRCGNCS...FT.S...L........E...D.....EAFCKNVSS...................ATASKT.TEP----...--S.EE....HNH..---.--HKHHD..KHG.HEHLG.....SSKPSENQ.QPGa.lDVETSL.PP..SGL.HHHHHHHkhk................................................................
A2I5C2_MYTGA/1-97                .....................................rqeyi-----------------.---------..----------.-...--------.-----------AH....GRTEISFMIVN....SKEAP.EQ............I............--GQLSS.......RTN-.....-F.......PVYQ...-DTNAINIWNKLNGG...KDDVLIYD..RCGKLV..YFIPFPSS....LL...RYHLTDWAIRTAYDTDACG---...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------c..................................................................
Q4RPX4_TETNG/1-185               ..........................................-----------------.---------..----------.-...--------.--MDSLRQKLENQ....GLRDVVYMVVN....HQGAQ.AR............G............LHAMLAQ.......RLSE.....HI.......SLHR...QDEALADVWQTLGGN...KDDFFIYD..RCGRLT..HRISLPYA....VI...GHGHVEKAVKDTYCSSLCGECT...HE.T...A........E...T.....QQECTPKT-...................--DTQP.QEDTRH-...-EC.HH....RHH..QGH.QHHGDGH..DHG.HGHHG.....GQGHHQGH.DQA...GGVAQR.PA..---.-------dadtdagcs..........................................................
H0UZB3_CAVPO/1-136               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......--SD.....HI.......SVYQ...QEQHQPDIWSRLKGN...KDDILIYD..RCGRLA..YHLRMPYS....FL...SFPYVEQAIKIVYCVEKCGNCS...LK.N...L........E...D.....DDFCKNVSL...................AAVT--.TEAPQKH...---.--....-HH..RQI.HPPK---..---.-----.....--------.---...------.--..---.-------rghpylgsrepeapdnpvqslplglhnlhrgq...................................
H2UNP3_TAKRU/22-266              ........................................eg--DGPRCQLPPVWKIGD.LEPMKEAMG..RVTVVALLES.S...WLSDFLHL.GRMDSLRQRLENQ....GLRDVVYMVVS....HQGAH.AP............G............LHAMLAQ.......KLTE.....HI.......SLYK...QDEALPDVWQTLGGN...NNDFFIYD..RCGRLT..HRISLPYS....II...GHGHVERAVKDTYCNSLCGECT...HE.T...T........E...T.....LQECTPKTS...................ALPDNG.VAPGAEE...TGH.EC....HHH..---.-GRQHHG..DGH.RDHGD.....-SQCTHTR.GS-...------.--..---.-------grghghhhghggqgqhegrvhmgdipqrpdh....................................
C3YH40_BRAFL/68-190              .......................................ggl-----------------.---------..----------.-...--------.-------QKLYSE....GKSDIFFGAVN....HWGWA.SW............W............YRGELER.......RAN-.....-F.......PVYQ...DSWS-QDIWGKLHAA...KDDILVYD..RCGRLA..YHLRLPRA....YL...GNTHTEEAIRAAYRQSPCGPCG...TL.A...G........E...T.....ATPC-----...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------ftrlsvirlk.........................................................
H3F8E2_PRIPA/108-245             .............................drddlssrqrlgl-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...--------------K...QGDVALFD..RCGRLS..RSLPLASTeelhQL...QQIFLQQVMKAAQHHAYCGWCQ...YG.T...E........S...GgeggrVDKKLDAFF...................QQAIAT.EAPNQQG...VYP.HH....HQQ..HNQ.QQHQQLQ..NQQ.HQYAQ.....HNQMQRPQ.HQ-...------.--..---.-------qqpsy..............................................................
Q9BDE4_BOVIN/1-129               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LS.R...P........Q...D.....EDVCKNVFL...................ATKEKT.AEASQRH...HHP.HP....HPH..---.-PHPHPH..PHHgHQLHE.....NAHLSESP.KPD..tPDTPEN.PP.tSGLhHHHHRHK...................................................................
A6GDZ9_9DELT/130-247             ..................................fqpqscnf---------------GE.TTSLEAYKG..RVTLVTLMRT.T...CEICQGTI.EKLEEMRLELELD....GY-DVYFLAIN....QMGYE.ST............Q............--QEFID.......RVA-.....-F.......PLL-...QDTAEVDAWELLNDTglgTDDIYIYG..ADGSL-..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------rsyfny.............................................................
A8Q424_BRUMA/14-218              .....................................kstpi-----LCSQTKSWKLGG.RDIIADSKG..FVLLVALMPM.E...CEHCHEQL.MKFQTVM-----E....TLPEIRIVVIT....PYDEN.PR............L............IERYRKE.......FSRV.....AI.......GI--...-ESLDERIWDTLSGS...GHDHFIYD..RCGRLA..SVIRHPKS...dTS...KFEHTLRALKSAISYAQCGWCQ...YD.P...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------pdlpqepvittyasftrkgktrrpvrqdqfvryteeiakeilyrkskreniseg.............
SEPP1_HUMAN/22-250               ..........................................QDQSSLCKQPPAWSIRD.QDPMLNSNG..SVTVVALLQA.S...UYLCILQA.SKLEDLRVKLKKE....GYSNISYIVVN....HQGIS.SR............L............KYTHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPFS....FL...TFPYVEEAIKIAYCEKKCGNCS...LT.T...L........K...D.....EDFCKRVSL...................ATVDKT.VET----...--P.SP....HYH..---.--HEHHH..NHG.HQHLG.....SSELSENQ.QPG..aPNAPTH.PA.pPGL.HHHHKHK...................................................................
F4X476_ACREC/858-977             .......................................itl-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...--------..-CGMLT..YHVIVPWS....IL...FFPYVKAAILSTYMDDPCGECN...PA.V...Y........R...A.....SNHEDHVVE...................LTKSTK.KELNPSY...REV.DT....KFE..IIW.TTESLPE..NLT.HLHYE.....SSSEEERE.---...------.--..---.-------tsiassillenitsdsdr.................................................
G1Q9G6_MYOLU/22-202              ..........................................QGQSPFCKPPPAWITLV.YVFIRYPH-..--STASLLKK.T...YYFCLRQA.SSLEDLRVKLEKE....GFSNISYVVVN....HQGHP.SR............L............RYNLLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPFS....IL...EFPYVEQAIKIAYCEEKCGNCS...LT.T...L........E...D.....EDFCKNMSL...................ATVRKT.TEASE--...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------phh................................................................
H2ZVW4_LATCH/22-227              ..........................................QGKSTRCKEPPTWYIGE.ENPMLESRG..KVTVVALLQA.S...SFYIILYV.SRMDDLHLKLENE....GLVNISYMIVN....HQGEY.SQ............H............KHNLLKQ.......RVSE.....FI.......PVYK...QDMEKPNVWNLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....VL...HFPYMEEAIRIAFCETRCGNCS...FT.V...K........D...I.....NEICNRT--...................ENTDEP.VEEPPPT...SVP.DP....PQQnpQHH.GAHRHHR..QHG.H----.....--------.---...------.--..---.-------q..................................................................
H9KP47_APIME/88-182              .................................eddtensme-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...-----IKA..CCGKIT..YQIIVPWS....IL...YFPYVKAAILSTYKDDPCGPCY...KK.I...N........K...N.....LDIRPEIF-...................TDATMP.VEESTRI...END.--....---..---.-------..---.-----.....--------.---...------.--..---.-------kytstvipfdsnnyk....................................................
F6Q9N1_XENTR/22-205              ........................................qg--HRKRCKEPPEWSIGD.QNPMMQSAG..KVTVVALLQA.S...RHQCLG--.FRLEDLRLKLEKE....KLVGISYVVVN....HQGRQ.SR............A............KYDLLKS.......KVSE.....HI.......PVYQ...QEEYQPDVWSLLKGD...KDDFFVYD..RCGRLV..QHLELPYS....LL...HFPYVEEAIRIAYCEDKCGECE...HK.K...P........E...E.....QQEQDKPVE...................EKVERP.RHHR--N...---.-H....HR-..---.-------..---.-----.....--------.---...------.--..---.-------hh.................................................................
Q16FG7_AEDAE/101-252             .....................................eqiql-----------------.---------..----------.-...--------.--FHNLFNRFEHN....GYRNVQFILGA....APSRHpDE............T............EFTEFEDf....ldNVTSvaagyNI.......SVYP...NPLNENGTFAMFGLK...EFQVYVVD..RCSRIS..YIIEPPWS....LI...QYSYVKAAVLSTMYDRPCGECD...VD.N...F........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------lnaslpekkldqfimlpalnvtetas.........................................
B7Q2F3_IXOSC/1-124               ........................................mf-----------------.---------..----------.-...------QI.ISLEALLLKLRAR....NLSDVQFLVVN....SL--D.SA............A............EVRQLER.......RVS-.....-F.......PVYQ...ET-ADEPVWSVLEGD...KDDVFIYD..RCGRLS..YFIPFPLS....VMlpgRHPVVEEALNTTYYASPCGD--...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------fcpqdpsatphrss.....................................................
F6V1F5_ORNAN/22-251              ..........................................QSASSHCKEAPRWQIRD.QDPMLNSLG..TVTVVALLQA.S...CYLCILQA.SRLEDLRVKLENE....GYSNISYIIVN....HQGMP.SQ............L............NHKTLKE.......KVSE.....HI.......PVYQ...QDEKQTDVWSTLKGN...KDDFLIYD..RCGRLV..YHLSLPYT....FL...SFSYVEDSIKTTYCEQNCGNCS...YT.M...P........E...A.....EEFCTNTSS...................AAKEKA.TEA-PLP...HND.RP....HHH..---.--HHHHH..HHG.--HKP.....HPSGTEQA.PAD...PDGPLRsPA.pQGL.HK-----rlr................................................................
G5APA7_HETGA/51-234              .....................................fpkyl-----------------.---------..----------.-...--------.-RFEDLRVKLEKE....GYSNISFVIVN....HQGSN.SR............L............KYIQLKN.......QVSD.....HI.......PVYQ...QEEHQTDVWSLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...SFPYVEEAIKIAYCEEKCGNCS...LR.T...L........E...D.....EDFCKNVSL...................ATVEKT.AEA----...--P.--....HPH..---.--NKQHH..KHG.HQHLG.....GSELSDNK.QPE..aPDNPVL.SP..LGH.HHHHE--l..................................................................
G9KN32_MUSPF/1-156               ..........................................-----------------.---------..----------.-...--LCILQA.SRLEDLRVKLEKE....GYLNISYVVVN....HQGLS.SQ............L............QYMNLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGK...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEEKCGNCS...LT.T...L........E...A.....KDFCEMVSS...................PTVGNT.TEA-PQP...HHH.HH....HHH..H-L.H------..---.-----.....--------.---...------.--..---.-------hh.................................................................
SEPP1_BOVIN/22-267               ..........................................QGQSSYCKQPPPWSIKD.QDPMLNSYG..SVTVVALLQA.S...UYLCILQA.SRLEDLRVKLEKE....GYSNISYVVVN....HQGIS.SR............L............KYVHLKN.......KVSE.....HI.......PVYQ...QEENQPDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LK.A...L........E...D.....EDVCKNVFL...................ATKEKT.AEASQRH...HHP.HP....HSH..PHP.HPHPHPH..PHP.HPHHGhqlheNAHLSESP.KPD..tPDTPEN.PP.pSGLhHHHHRHK...................................................................
Q7Q0I7_ANOGA/145-295             ........................lageynlttypnrlnenr-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...-------TFALFGLR...EFQVYVID..RCSRVS..YIIQPPWS....LI...QYAYVKAAVLSTFYDRPCGKCE...LE.N...F........L...N.....STLTDGEKLs.................dVKADPT.KDATPYD...DAS.DE....FSN..---.-PAEEEE..DHD.GGVRA....ySEEEDDDD.ESD...TD----.--..---.-------gngrtvdeykads......................................................
SELPB_DANRE/27-265               .........................................s-NGSRICKPAPQWEIDG.KTPMKELLG..NVVVVALLKA.S...UHFCLTQA.ARLGDLRDKLANG....GLTNISFMVVN....EQDSQ.SR............A............MYWELKR.......RTAQ.....DI.......PVYQ...QSPLQNDVWEILEGD...KDDFLVYD..RCGYLT..FHIVLPFS....FL...HYPYIEAAIRATYHKNMC-NCS...LN.A...N........F...S.....ISESSDSTKnd..............pagENNQRP.NSTEPVT...--A.AH....HHH..---.--HQQHE..PHH.HHHNP....yPNSHKKSG.DSD..vTGKPKE.PP.hHSHqEHVHNHR...................................................................
F6PUF8_HORSE/22-252              ..........................................QGQSSFCKQPPAWSIRD.QDPMLNSYG..SVTVVALLQA.S...CYLCLLQA.SRLEDLRVKLEKE....GYSNISYVVVN....HQEIS.AR............L............KYIHLKN.......KVSE.....YI.......AVYQ...QEENQTDIWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEKKCGNCS...LM.T...L........E...D.....EDFCKTLSL...................ATVEKT.TEDS---...-QP.HH....HHH..---.--HQHHH..KHG.HQHVG.....NSQLSENQ.QPE..aTGAPEH.PP.pPGL.HHHHKHK...................................................................
E1FTD5_LOALO/3-160               .....................................estpi-----LCSQTKPWKLSG.RDIVSDSKG..LVLLVVLMPM.E...CEHCHKQL.MKFQTVM-----E....TLPEIRIVVVA....PHDEN.PR............L............I-ERYRE.......EFP-.....RV.......AIGM...-ESLDERIWNTLSGS...AHDHFIYD..RCGRLA..SIIRHPES...dTS...KFEHTLWALKLAISYAQCGWCQ...Y-.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------dppdlpsph..........................................................
H3DJR4_TETNG/1-205               ..........................................-----------------.---MEALVG..RVVVVALLKA.S...TPPCDAPF.PRIGPLREKLSRR....NVTEVSFVIVN....EQEPV.SR............A............LYWQLRR.......RAPP.....GV.......PVYQ...QAPLQDDVWEALDGD...KDDFLIYD..RCGQLT..FHIGLPYS....SL...RYTYVEAAVIATYQGNIC-NCS...AN.C...H........I...S.....EHQQQQRKW...................RDAQSD.QPDGHCG...DRW.ST....HYP..PPPsPSPPATH..THT.-----.....--------.---...------.--..---.-------darpshthtsldlppppptsr..............................................
A7RTX8_NEMVE/22-189              .......................................aes---AGVCQRPRPWTVNG.MDPMAQARAdkQIVVLALMEArA...CGICVRQA.KAMESLLTMLRQRersyQLGNLSFMIVN....HHMAA.GS............I............RFIE--G.......RVS-.....-F.......PVYQ...EN-ANKQIWPAVDGA...KDDIIVYD..RCGGLV..SHLKWPKS....DL...TKPHLWQAIQRAKWSKAC--CK...Q-.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------qttepptisdgg.......................................................
E0CZ76_MOUSE/22-124              ..........................................QGQSSACYKAPEWYIGD.QNPMLNSEG..KVTVVALLQA.S...CYLCLLQA.SRLEDLRIKLESQ....GYFNISYIVVN....HQGSP.SQ............L............KHSHLKK.......QVSE.....HI.......AVYR...QEEDGIDVW------...--------..------..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
F6VJE4_XENTR/24-265              ..........................................QTNSSICKPPPKWSIEG.EVPMAEALG..KVTVVALLQA.S...CGFCLVQA.ARMGPLRYKLSLQ....GMTDIKYMIVN....DQSLH.SA............N............MFPELKR.......WAPE.....GI.......PVYQ...QTPGQDDVWELLDGN...KDDFLIYD..RCGRLT..FHVRLPLS....FL...HFPYVEAAILSTYNESFCGNCS...FT.S...N........S...T.....LIPMNGTTVspsgd........dsssplQNKDEP.VNKEPSP...TLE.KH....NDQ..RKL.DSELRLH..DHS.QHHPI.....-NSHKRQE.NQN...------.--..---.-------nhprnlikngkq.......................................................
E2AE76_CAMFO/127-281             ..............................vntnlffedses-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....-E.......IIFL...QDDPQFRIWERFRAS...KDQVVVID..RCGQLT..YQIMVPWS....IL...YFPYVKAAILSTHQEDPCGGCD...PT.M...Y........Q...D.....PDYE-----...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------dyfpnsrsttkgtdqyetdkinaeliwtteqwssgngsvhleeslkeehetnivppvisdkithdsd
H2PXQ5_PONAB/22-250              ..........................................QDQSSLCKQPPAWSIRD.QDPMLNSNG..SVTVVALLQA.S...CYLCILQA.SKLEDLRVKLKKE....GYSNISYIVVN....HQGIS.SR............L............KYTHLKN.......KVSE.....HI.......PVYQ...QEENQTDVWTLLNGS...KDDFLIYD..RCGRLV..YHLGLPFS....FL...TFPYVEEAIKIAYCEKKCGNCS...LT.T...L........K...D.....EDFCKSVSL...................ATVDKT.VEA----...--P.SP....HYH..---.--HEHHH..NHG.HQHLG.....SSELSENQ.QPG..aPDAPTH.PA.pPGL.HHHHKHK...................................................................
Q6DJ72_XENTR/12-253              ..........................................QTNSSICKPPPKWSIEG.EVPMAEALG..KVTVVALLQA.S...CGFCLVQA.ARMGPLRYKLSLQ....GMTDIKYMIVN....DQSLH.SA............N............MFPELKR.......WAPE.....GI.......PVYQ...QTPGQDDVWELLDGN...KDDFLIYD..RCGRLT..FHVRLPLS....FL...HFPYVEAAILSTYNESFCGNCS...FT.S...N........S...T.....LIPMNGTTVspsgd........dsssplQNKDEP.VNKEPSP...TLE.KH....NDQ..RKL.DSELRLH..DHS.QHHPI.....-NSHKRQE.NQN...------.--..---.-------nhprnlikngkq.......................................................
B5DDI2_DANRE/1-174               ..........................................-----------------.---------..----------.-...--------.-------------....-------MVVN....EQDSQ.SR............A............MYWELKR.......RTAQ.....DI.......PVYQ...QSPLQNDVWEILEGD...KDDFLVYD..RCGYLT..FHIVLPFS....FL...HYPYIEAAIRATYHKNMC-NCS...LN.A...N........F...S.....ISESPDSTKne..............pagENNQRP.NSTEPVT...--A.AH....HHH..---.--HQQHE..PHH.HHHNP....yPNSHKKSG.DSD..vTGKPKE.PT.hHSHqEHVHNHR...................................................................
F1N9T1_CHICK/1-128               ..........................................-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...KDDFLIYD..RCGRLV..YHLGLPYS....FL...SFQYVEEAIKIAYCENNCGNCS...YT.E...P........D...I.....DNICENITK...................KEDENL.AGIEPEP...EPS.GQ....HSH..HHH.QL--HRH..RHH.HHHRE.....GGRHSKTQ.NHQapsESQRRH.PH..NGR.Q------eqki...............................................................
E0CX80_MOUSE/22-139              ..........................................QGQSSACYKAPEWYIGD.QNPMLNSEG..KVTVVALLQA.S...CYLCLLQA.SRLEDLRIKLESQ....GYFNISYIVVN....HQGSP.SQ............L............KHSHLKK.......QVSE.....HI.......AVYR...QEEDGIDVWTLLNGN...KDDFLIYD..R-----..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
F4X476_ACREC/84-323              .............................eqdwyfeqcrfvn-----------------.--AWKEHLG..HVSVLAFLDS.A...WQYSFRQA.VMLELLSSRLRKS....GFPDIRFFVISpssdSKGDK.SEddleieawreigA............KY-EMENfvnsdflKNNE.....TE.......IIFL...QDDPQSRIWERFRAS...REHAVIID..RCGMLT..YHVIVPWS....IL...FFPYVKAAILSTYMDDPCGECN...PA.V...Y........R...A.....SNHEDHVVE...................LTKSTK.KELNPSY...REV.DT....KFE..IIW.TTESLPE..NLT.HLHYE.....SSSEEER-.---...------.--..---.-------etsiassi...........................................................
SEPP1_MOUSE/22-248               ..........................................QGQSSACYKAPEWYIGD.QNPMLNSEG..KVTVVALLQA.S...UYLCLLQA.SRLEDLRIKLESQ....GYFNISYIVVN....HQGSP.SQ............L............KHSHLKK.......QVSE.....HI.......AVYR...QEEDGIDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEERCGNCN...LT.S...L........E...D.....EDFCKTVTS...................ATANKT.AEP----...--S.EA....HSH..---.--HKHHN..KHG.QEHLG.....SSKPSENQ.QPG...PSETTL.PP..SGL.HHHHRHR...................................................................
Q9N0N7_CAPHI/22-205              ..........................................QGQSSYCKQPPAWSIKD.QDPMLNSYG..SVTVVALLQA.S...XYLCILQA.SRLEDLRVKLEKE....GYSNISYVVVN....HQEIS.SR............L............KYVHLKN.......KVSE.....HI.......PVYQ...QEDDQPDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFTYVEDSIKTVYCEDKCGNCS...LK.T...Q........E...D.....EDFCKNVSL...................ATKEKT.AEASQRH...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------h..................................................................
SEPP1_RAT/22-253                 ..........................................QGQSPACKQAPPWNIGD.QNPMLNSEG..TVTVVALLQA.S...UYLCLLQA.SRLEDLRIKLENQ....GYFNISYIVVN....HQGSP.SQ............L............KHAHLKK.......QVSD.....HI.......AVYR...QDEHQTDVWTLLNGN...KDDFLIYD..RCGRLV..YHLGLPYS....FL...TFPYVEEAIKIAYCEKRCGNCS...FT.S...L........E...D.....EAFCKNVSS...................ATASKT.TEP----...--S.EE....HNH..---.--HKHHD..KHG.HEHLG.....SSKPSENQ.QPGa.lDVETSL.PP..SGL.HHHHHHHkhk................................................................
E0CY03_MOUSE/32-110              ..........................................QGQSSACYKAPEWYIGD.QNPMLNSEG..KVTVVALLQA.S...CYLCLLQA.SRLEDLRIKLESQ....GYFNISYIVVN....HQGSP.SQ............L............KH-----.......----.....--.......----...---------------...--------..------..--------....--...----------------------...--.-...-........-...-.....---------...................------.-------...---.--....---..---.-------..---.-----.....--------.---...------.--..---.-------...................................................................
H3J6C3_STRPU/83-213              ........................................ls-----------------.---------..----------.-...--------.-------------....-----------....-----.--............-............-------.......----.....--.......----...---------------...--------..-CGQLT..YHIPMPYS....AL...RYPFIQIAIESTYTGRHPCNCS...AD.E...P........T...T.....TAMPSTEKPhk...............tpSDRKRS.LRH-AVS...DNN.NN....NYY..-RK.SGEMQSAliDRT.DADADpg.rvKVNCDRNS.-PQ..tADDLET.PP..PQR.HH-----dvrvns.............................................................
Q6P3K0_DANRE/22-253              .........................................e-TEGARCKLPPEWKVGD.VEPMKNALG..QVTVVAYLQA.S...ULFCLEQA.SKLNDLLLKLENQ....GYPNIAYMVVN....NREER.SQ............R............LHHLLQE.......RLL-.....NI.......TLYA...QDLSQPDAWQAVNAE...KDDILVYD..RCGRLT..YHLSLPYT....IL...SHPHVEEAIKHTYCDRICGECS...LE.S...S........A...Q.....LEECKKAT-...................EEVNKP.VEEEPRQ...DHG.HH...eHGH..HEH.QGEAERH..RHG.HHHPH.....HHHHHHRG.QQQ...VD----.--..---.-------vdqqvlsqvdf........................................................
#=GC seq_cons                    ...........................................................................hs.h..............h..phtsLp.+Ltpp....Gh.slpahlVN....pps...Sp............h............ha..Lpp.......pss......tl.......sVYp...Qp.tpsDlWphLsGs...KDDFLIYD..RCGRLs..YHlsLPaS....hL...pasYVEtAI+hsYpcphCGsCo...hp.s............t...s......p.spth......................t.pps..p............t.....p.......................................................................................................................................
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