GenomeNet

Database: Pfam
Entry: SelP_N
LinkDB: SelP_N
Original site: SelP_N 
#=GF ID   SelP_N
#=GF AC   PF04592.11
#=GF DE   Selenoprotein P, N terminal region
#=GF AU   Kerrison ND
#=GF SE   DOMO:DM04433;
#=GF GA   23.20 23.20;
#=GF TC   23.80 25.10;
#=GF NC   22.20 23.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Selenoprotein_P
#=GF RN   [1]
#=GF RM   10775431
#=GF RT   Selenoprotein P: properties, functions, and regulation. 
#=GF RA   Mostert V; 
#=GF RL   Arch Biochem Biophys 2000;376:433-438.
#=GF RN   [2]
#=GF RM   11168591
#=GF RT   Selenium metabolism in zebrafish: multiplicity of selenoprotein
#=GF RT   genes and expression of a protein containing 17 selenocysteine
#=GF RT   residues. 
#=GF RA   Kryukov GV, Gladyshev VN; 
#=GF RL   Genes Cells 2000;5:1049-1060.
#=GF RN   [3]
#=GF RM   9358058
#=GF RT   Analysis of bovine selenoprotein P-like protein gene and
#=GF RT   availability of metal responsive element (MRE) located in its
#=GF RT   promoter. 
#=GF RA   Fujii M, Saijoh K, Kobayashi T, Fujii S, Lee MJ, Sumino K; 
#=GF RL   Gene 1997;199:211-217.
#=GF DR   INTERPRO; IPR007671;
#=GF CC   SelP is the only known eukaryotic selenoprotein that contains
#=GF CC   multiple selenocysteine (Sec) residues, and accounts for more
#=GF CC   than 50% of the selenium content of rat and human plasma [1]. 
#=GF CC   It is thought to be glycosylated [2].  SelP may have antioxidant
#=GF CC   properties.  It can attach to epithelial cells, and may protect
#=GF CC   vascular endothelial cells against peroxynitrite toxicity [1].
#=GF CC   The high selenium content of SelP suggests that it may be
#=GF CC   involved in selenium intercellular transport or storage [2]. The
#=GF CC   promoter structure of bovine SelP suggest that it may be
#=GF CC   involved in countering heavy metal intoxication, and may also
#=GF CC   have a developmental function [3]. The N-terminal region of SelP
#=GF CC   can exist independently of the C terminal region.  Zebrafish
#=GF CC   selenoprotein Pb (Swiss:Q98SV0) lacks the C terminal Sec-rich
#=GF CC   region, and a protein encoded by the rat SelP gene and lacking
#=GF CC   this region has also been reported [2]. N-terminal region
#=GF CC   contains a conserved SecxxCys motif, which is similar to the
#=GF CC   CysxxCys found in thioredoxins.  It is speculated that the N
#=GF CC   terminal region may adopt a thioredoxin fold and catalyse redox
#=GF CC   reactions [2]. The N-terminal region also contains a His-rich
#=GF CC   region, which is thought to mediate heparin binding.  Binding to
#=GF CC   heparan proteoglycans could account for the membrane binding
#=GF CC   properties of SelP [1].  The function of the bacterial members
#=GF CC   of this family is uncharacterised.
#=GF SQ   97
#=GS G1KQP6_ANOCA/26-179      AC G1KQP6.1
#=GS A0A0B2VN39_TOXCA/20-211  AC A0A0B2VN39.1
#=GS H0ZC10_TAEGU/1-47        AC H0ZC10.1
#=GS H2SF16_TAKRU/1-110       AC H2SF16.1
#=GS E0CZ76_MOUSE/23-124      AC E0CZ76.1
#=GS A0A067R8W1_ZOONE/3-168   AC A0A067R8W1.1
#=GS Q7Q0I7_ANOGA/166-293     AC Q7Q0I7.4
#=GS F6V1E8_ORNAN/23-255      AC F6V1E8.2
#=GS G3W9K6_SARHA/23-176      AC G3W9K6.1
#=GS V4A4R8_LOTGI/1-157       AC V4A4R8.1
#=GS W5JI27_ANODA/146-291     AC W5JI27.1
#=GS G3ID68_CRIGR/21-166      AC G3ID68.1
#=GS G1KY65_ANOCA/23-58       AC G1KY65.1
#=GS G1LAZ4_AILME/4-242       AC G1LAZ4.1
#=GS W5L435_ASTMX/10-143      AC W5L435.1
#=GS SEPP1_PONAB/23-249       AC Q5R8W9.2
#=GS H1A5G2_TAEGU/1-124       AC H1A5G2.1
#=GS E9QB63_DANRE/23-254      AC E9QB63.1
#=GS SEPP1_RAT/23-248         AC P25236.2
#=GS G3PMU8_GASAC/1-188       AC G3PMU8.1
#=GS G3NUN5_GASAC/1-216       AC G3NUN5.1
#=GS D6REX5_HUMAN/23-249      AC D6REX5.1
#=GS A0A0G2JU99_RAT/23-203    AC A0A0G2JU99.1
#=GS W5MN82_LEPOC/23-267      AC W5MN82.1
#=GS F6VJE4_XENTR/25-266      AC F6VJE4.1
#=GS A8Q426_BRUMA/7-208       AC A8Q426.2
#=GS W4Z1T3_STRPU/83-177      AC W4Z1T3.1
#=GS U3K9A0_FICAL/19-264      AC U3K9A0.1
#=GS F1RD74_DANRE/28-263      AC F1RD74.1
#=GS U3JR44_FICAL/27-249      AC U3JR44.1
#=GS V8NYH9_OPHHA/29-180      AC V8NYH9.1
#=GS G3UU18_MELGA/1-166       AC G3UU18.1
#=GS U3IXD6_ANAPL/13-195      AC U3IXD6.1
#=GS A0A0D9RW51_CHLSB/1-190   AC A0A0D9RW51.1
#=GS W4X313_ATTCE/135-288     AC W4X313.1
#=GS R4GMT5_HUMAN/23-77       AC R4GMT5.1
#=GS W5PG55_SHEEP/23-207      AC W5PG55.1
#=GS V8PHU7_OPHHA/20-55       AC V8PHU7.1
#=GS E2AE76_CAMFO/129-280     AC E2AE76.1
#=GS A0A044QQ64_ONCVO/31-263  AC A0A044QQ64.1
#=GS E0CX80_MOUSE/23-139      AC E0CX80.1
#=GS B0W3C3_CULQU/144-295     AC B0W3C3.1
#=GS E0CY03_MOUSE/33-110      AC E0CY03.1
#=GS M4A9J5_XIPMA/5-210       AC M4A9J5.1
#=GS Q16FG7_AEDAE/94-251      AC Q16FG7.1
#=GS M3XHZ2_LATCH/1-183       AC M3XHZ2.1
#=GS SEPP1_MOUSE/23-268       AC P70274.3
#=GS F4X476_ACREC/178-323     AC F4X476.1
#=GS A0A087XRM9_POEFO/1-178   AC A0A087XRM9.2
#=GS J0XLE8_LOALO/31-255      AC J0XLE8.1
#=GS M3YSM4_MUSPF/1-167       AC M3YSM4.1
#=GS F7EK34_ORNAN/12-166      AC F7EK34.1
#=GS R4GJB1_CHICK/1-203       AC R4GJB1.1
#=GS J9NST4_CANFA/1-138       AC J9NST4.1
#=GS G3TLW1_LOXAF/23-207      AC G3TLW1.1
#=GS SEPP1_BOVIN/23-290       AC P49907.2
#=GS A7RTX8_NEMVE/23-190      AC A7RTX8.1
#=GS F4X476_ACREC/858-966     AC F4X476.1
#=GS H2UNP3_TAKRU/23-253      AC H2UNP3.1
#=GS A0A077ZBY8_TRITR/1-193   AC A0A077ZBY8.1
#=GS H3DGX7_TETNG/23-251      AC H3DGX7.1
#=GS F6PUF8_HORSE/23-250      AC F6PUF8.1
#=GS G5APA7_HETGA/37-233      AC G5APA7.1
#=GS J9FD25_WUCBA/10-174      AC J9FD25.1
#=GS M4ANC2_XIPMA/23-205      AC M4ANC2.1
#=GS F1N9T1_CHICK/1-159       AC F1N9T1.2
#=GS H3DJR4_TETNG/1-201       AC H3DJR4.1
#=GS E0CZC5_MOUSE/23-177      AC E0CZC5.1
#=GS H2PXQ5_PONAB/1-188       AC H2PXQ5.2
#=GS H3CE96_TETNG/6-134       AC H3CE96.1
#=GS G1Q9G6_MYOLU/23-202      AC G1Q9G6.1
#=GS F6Q9N1_XENTR/23-205      AC F6Q9N1.1
#=GS I3JR88_ORENI/1-180       AC I3JR88.1
#=GS D6RIS9_HUMAN/23-209      AC D6RIS9.1
#=GS W5KEM0_ASTMX/23-259      AC W5KEM0.1
#=GS A0A088AAX3_APIME/26-230  AC A0A088AAX3.1
#=GS A0A096MFI7_POEFO/5-209   AC A0A096MFI7.1
#=GS C3YH40_BRAFL/68-195      AC C3YH40.1
#=GS A0A093BFN6_CHAPE/1-116   AC A0A093BFN6.1
#=GS SEPP1_HUMAN/23-249       AC P49908.3
#=GS H0UZB3_CAVPO/1-141       AC H0UZB3.1
#=GS E5SI43_TRISP/46-261      AC E5SI43.1
#=GS A0A096M0U7_POEFO/1-106   AC A0A096M0U7.1
#=GS I3LJP2_PIG/5-135         AC I3LJP2.1
#=GS B7Q2F3_IXOSC/1-206       AC B7Q2F3.1
#=GS H2MB78_ORYLA/1-159       AC H2MB78.1
#=GS SELPA_DANRE/23-255       AC Q98SV1.3
#=GS K7E6A4_MONDO/1-186       AC K7E6A4.1
#=GS K7JYM3_NASVI/162-308     AC K7JYM3.1
#=GS W5M4W3_LEPOC/1-173       AC W5M4W3.1
#=GS W5MN70_LEPOC/1-198       AC W5MN70.1
#=GS SELPB_DANRE/28-263       AC Q98SV0.3
#=GS I3KDC0_ORENI/1-102       AC I3KDC0.1
#=GS A0A096M1E4_POEFO/1-185   AC A0A096M1E4.1
#=GS U3KMC5_RABIT/1-197       AC U3KMC5.1
#=GS H2ZVW4_LATCH/23-227      AC H2ZVW4.1
#=GS G3WG53_SARHA/1-198       AC G3WG53.1
G1KQP6_ANOCA/26-179                 ..........................................n-KTRICQPAPLWKIN.GTAPMAGMEG..QVTVVALLKAS...M..LV.IS.LP.AISIGGL....QKKLSNEGVANVSFLIV............N..........EK.TPLSRAMYWE.LKRNA.PQ....GIP......VYQQQIL.EPDVWQ.ILDGDKDDFLIY..D.....RCSRLTFHIQLPYS.FL...H.LPYVEAAVHYTHRKDYCGN.CS---.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
A0A0B2VN39_TOXCA/20-211             ........................................lpp----ICDHSTRWTVG.ERDIVHESRG..FILLAVFMPLQ...G..SS.NIhTQ.LMKLQAI....-----GETIREVRVVVI............A..........PQ.NEDSRLLD-R.YRAQF.PQ....--V......TFEMESA.NEPAWA.ALGASAYDHFIY..D.....RCGRIANVIRHPRSdIA...R.FEDTVNSLKGAINYAHCGW.CNYNL.R..........TA...PT..PALI.A.PE...............MHKRRARETESS....--..-.---...---....-......----..----.-------.....-----------.....------..----------ekcesishllvnelqita................................................................
H0ZC10_TAEGU/1-47                   ...........................................---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.-----KDDFLVY..D.....RCGRLAFHIQLPFS.FL...H.FPYVEAAIRSSHIKDFCGN.CSL--.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
H2SF16_TAKRU/1-110                  ...........................................---------------.----------..-----------...-..--.--.--.--RIGGL....RKKLIQSNMTEVSYMIV............N..........EQ.DPHSRALFWE.LERRA.PP....DVP......VYQQSAF.QSDVWE.TLDGDKDDFLIY..D.....RCGQLTFHVGLPYS.FL...N.YVYVEAAIRATYQGNIC-N.CSV--.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------s.................................................................................
E0CZ76_MOUSE/23-124                 ..........................................g-QSSACYKAPEWYIG.DQNPMLNSEG..KVTVVALLQAS...C..YL.CL.LQ.ASRLEDL....RIKLESQGYFNISYIVV............N..........HQ.GSPSQLKHSH.LKKQV.SE....HIA......VYRQEED.GIDVW-.------------..-.....--------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
A0A067R8W1_ZOONE/3-168              ...................................fvryhmkt---------------.----------..-----------...-..--.--.-Y.IFRMQDL....QVRLISAGFTNIAFRII............N..........SKlAVDGTDGFAT.LKHK-.SG....DIP......VLQEPKDiTSSIWQsILDGGIDHILVL..D.....RCGRLVYQVISPWS.LL...S.YPYVKAAILSTYNDDPCGP.CNLLV.T..........EQ...TR..NNTD.T.SM...............EDKTIPRA----....--..-.---...---....-......----..----.-------.....-----------.....------..----------elsssitltkergttianntk.............................................................
Q7Q0I7_ANOGA/166-293                .....................................lfglre---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.--------FQVYviD.....RCSRVSYIIQPPWS.LI...Q.YAYVKAAVLSTFYDRPCGK.CELEN.F..........LN...ST..LTDG.EkLS...............DVKADPTKDATP....Y-..D.DAS...DEF....S......NPAE..EEED.----HDG....gVRAYSEEEDDD.....DE----..----------sdtdgngrtvdeyka...................................................................
F6V1E8_ORNAN/23-255                 ..........................................s-ASSHCKEAPRWQIR.DQDPMLNSLG..TVTVVALLQASsiiC..IF.FL.LK.PFRLEDL....RVKLENEGYSNISYIIV............N..........HQ.GMPSQLNHKT.LKEKV.SE....HIP......VYQQDEK.QTDVWS.TLKGNKDDFLIY..Dr...sRCGRLVYHLSLPYT.FL...S.FSYVEDSIKTTYCEQNCGN.CSYTM.P..........EA...EE..FCTN.T.SS...............AAKEKATEA-PL....PH..N.DRP...HHH....-......--H-..-HHH.HHHGHKP.....HPSGTEQAPAD.....PDGPLR.sPAPQGLHK--rl................................................................................
G3W9K6_SARHA/23-176                 ..........................................n-GTRICQPAPDWQVDgGVSPMEEALG..NVTEVALLKAP...L..TR.P-.FL.APRIGSL....QERLARAGTAGVRFLIV............N..........HK.SAAAQALQGE.LELRA.PR....GVP......VYSQRGP.RPDIWG.LLGGAKDDFLVY..D.....RCGRLTFHIQLPFS.AL...S.FPFVEAAVRFSHQQDHCGN.CS---.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
V4A4R8_LOTGI/1-157                  .........................................ma---------------.----------..-----------...-..--.--.-K.NRKLQTL....KNDLALENKPDVNFFII............N..........G-.-EHSQEL---.IGRFP.SI....EIP......IYQ-DTE.QLGLWRtVFAGNKDDFIIF..D.....RCGRRVYHIPLPYS.DL...R.LNYTRYAIDVVYNRRVCGE.CDSSS.N..........YM...DR..MMGD.Q.P-...............-ASTDVDEHVDI....VG..Q.SDT...---....-......YRHR..RRQR.HGRHQ--.....-----------.....------..----------drdm..............................................................................
W5JI27_ANODA/146-291                ......................adernltvypnpltengtfal---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.-LGLREFQVYVI..D.....RCSRVSYIIEPPWS.LI...Q.FSYVKAAVLSTFYDRPCGK.CEFEN.Y..........IN...ST..ISDE.D.RN...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------pspgakdatagcinghgpsctemfeesienaeedeggmqdseeddedsysytrtkdesdp......................
G3ID68_CRIGR/21-166                 ....................................cdrpdgp---------------.----------..-----------...-..--.--.--.-NRLEDL....RLKLENQGYSNISYIIV............N..........HQ.GSPSQLKHTH.LKNHV.SD....QIA......VYRQEEH.QTDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEKKCRN.CSFTL.L..........RV...KR..R---.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------sprrhitttstitntgtgfl..............................................................
G1KY65_ANOCA/23-58                  .........................................gp--STRCKEPPDWRIG.EQNPMLDSRG..FVTVVALLQAS...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....--------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
G1LAZ4_AILME/4-242                  ..........................................g-QSSFCKQPPAWSIR.DQSPMLNSGG..SVTVVALLQAS...S..KY.LL.GR.IYRLEDL....RVKLEKEGYLNISYVVV............N..........HQ.GLPSQLKYMH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGKKDDFLVY..D.....RCGRLVHHLGLPYS.FL...T.FPYVEEAIKIAYCEEKCGN.CSLMQ.Ninin..sltqEA...ED..FCKM.V.SS...............ATVGTTTEAPPP....HH..H.HHH...HHH....-......--HR..HHHK.HGHPHHG.....NDELSEDQQPE....aEQAREH..PAPRGLHRHH..................................................................................
W5L435_ASTMX/10-143                 .......................................ilsl---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.--------FLFC..A.....SCGQLTFHIVLPYS.YL...H.HPYVEAAIRATYHRDIC-N.CTVDS.Ns.......tlSD...EQ..QNST.T.V-...............TTGTSPSQISEEppadPA..R.PVN...GHH....H......HSQT..HGHY.HPTHSHP.....VITKAEDRNIG.....VSHHHT..-HDEGQES--haihkh............................................................................
SEPP1_PONAB/23-249                  ..........................................d-QSSLCKQPPAWSIR.DQGPMLNSNG..SVTVVALLQAS...U..YL.CI.LQ.ASKLEDL....RVKLKKEGYSNISHIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FPYVEEAVKIAYCEKKCGY.CSLTT.L..........KD...ED..FCKS.V.SL...............ATVDKTVEA---....--..-.PSP...HYH....-......--HE..HHHN.HRHQHLG.....SSELSENQQPG....aPDAPTH..PAPPGLHHHHkh................................................................................
H1A5G2_TAEGU/1-124                  ...........................................---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.-----KDDFLIY..D.....RCGRLVYHLGMPYS.FL...H.FQYVEESIKIAYCENKCGN.CSYME.P..........DA...DG..VCEN.I.TK...............KAVEELSEIEPK....PT..G.QHS...HPNl..hR......HGHH..QRHH.HHHHHHKg...sRDPKHENHQAA.....AEAERH..HPHS------g.................................................................................
E9QB63_DANRE/23-254                 ..........................................t-EGARCKLPPEWKVG.DVEPMKNALG..QVTVVAYLQAS...C..LF.CL.EQ.ASKLNDL....LLKLEKQGYPNIAYMVV............N..........NR.EERSQRLHHL.LQERL.L-....NIT......LYAQDLS.QPDAWQ.AVNAEKDDILVY..D.....RCGRLTYHLSLPYT.IL...I.HPHVEEAIKHTYCDRICGE.CSLES.S..........AQ...LE..ECKK.A.T-...............EEVNKPVEEEPR....QD..H.GHHeqgHHE....H......QGEA..ERHR.HGHHHPHh...hHHHHRGQQQVD.....------..----------vdqqvlsqvdfg......................................................................
SEPP1_RAT/23-248                    ..........................................g-QSPACKQAPPWNIG.DQNPMLNSEG..TVTVVALLQAS...U..YL.CL.LQ.ASRLEDL....RIKLENQGYFNISYIVV............N..........HQ.GSPSQLKHAH.LKKQV.SD....HIA......VYRQDEH.QTDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEKRCGN.CSFTS.L..........ED...EA..FCKN.V.SS...............ATASKTTEP---....--..-.SEE...HNH....-......--HK..HHDK.HGHEHLG.....SSKPSENQQPG....aLDVETS..LPPSGLHHHHh.................................................................................
G3PMU8_GASAC/1-188                  ...........................................---------------.----------..-----------...-..--.--.--.-------....--------------MIV............N..........ER.EPHSRAMYWE.LKRRA.PP....GVP......VYQQAAL.QSDVWE.ALDGDKDDFLVY..D.....RCGLLTFHIVLPYS.FL...H.NVYVEAAIRATYLKNIC-N.CTVDS.VvsslnnsvmnN-...--..----.E.TDfnvsqtnatpriqpdTNDPEGAGTPPP....PT..H.HHS...HHH....H......HHHQ..HHHP.HHPHHAH....lNQPLHDTSQNI.....TRHPLS..VHHHHH----phhhh.............................................................................
G3NUN5_GASAC/1-216                  ...........................................---------------.----------..-----------...-..--.--.--.---MDGL....RQKLESQGLKDVAYMVV............N..........QQ.GEQARRLHPM.LAQRL.SV....NID......LYKQDEQ.QPDVWK.TLGGDKDDFLVY..D.....RCGRLTHHIALPYS.II...G.QGHVESAIKDAYCKRTCGD.CVHES.A..........TT...PE..ECVE.K.AVa............qpDADAPPVVEDNG....GGggH.HGH...HHH....G......HGHH..RGHH.HGHHHGH.....HHGGDHGAGQQavvhqEHERDG..GASHGQH---nsaldqmqqqahipqmphgaqa............................................................
D6REX5_HUMAN/23-249                 ..........................................d-QSSLCKQPPAWSIR.DQDPMLNSNG..SVTVVALLQAS...C..YL.CI.LQ.ASKLEDL....RVKLKKEGYSNISYIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FPYVEEAIKIAYCEKKCGN.CSLTT.L..........KD...ED..FCKR.V.SL...............ATVDKTVET---....--..-.PSP...HYH....-......--HE..HHHN.HGHQHLG.....SSELSENQQPG....aPNAPTH..PAPPGLHHHHkh................................................................................
A0A0G2JU99_RAT/23-203               ..........................................g-QSPACKQAPPWNIG.DQNPMLNSEG..TVTVVALLQAR...H..FM.CF.L-.-PRLEDL....RIKLENQGYFNISYIVV............N..........HQ.GSPSQLKHAH.LKKQV.SD....HIA......VYRQDEH.QTDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEKRCGN.CSFTS.L..........ED...EA..FCKN.V.SS...............ATASKTTEPSEE....H-..-.---...---....-......----..----.-------.....-----------.....------..----------n.................................................................................
W5MN82_LEPOC/23-267                 .........................................gg--GGRCKTPPEWAVG.NEQPMTDSAG..RVTVVALLQLN...Y..LVqNL.IF.LNRLDVL....RLRLEQQGLVNISYVVV............N..........HQ.GEQSHRLYPV.LKKKM.SQ....KIR......VYDQDPL.QEDVWK.ILSGEKDDFLIY..D.....RCGSLTHHLGLPYS.ML...T.MSYVEDAIRDTYCKDICGN.CSLES.S..........SL...PV..TCNS.T.VKp............egKPEDKPEESPES....HG..H.PHA...HGHg..hHhseegrQSHR..RHSS.HGHHHGH.....GRHHHGSQQEF.....NNGQTQ..RHSQTHQQQ-q.................................................................................
F6VJE4_XENTR/25-266                 ..........................................t-NSSICKPPPKWSIE.GEVPMAEALG..KVTVVALLQAS...C..GF.CL.VQ.AARMGPL....RYKLSLQGMTDIKYMIV............N..........DQ.SLHSANMFPE.LKRWA.PE....GIP......VYQQTPG.QDDVWE.LLDGNKDDFLIY..D.....RCGRLTFHVRLPLS.FL...H.FPYVEAAILSTYNESFCGN.CSFTS.N..........ST...LI.pMNGT.T.VSpsgdd.....sssplQNKDEPVNKEPS....PT..L.EKH...NDQ....R......KLDSelRLHD.HSQHHPI.....-NSHKR-QENQ.....NNHPR-..----------nlikngkqn.........................................................................
A8Q426_BRUMA/7-208                  .......................................stpi----LCSQTKSWKLG.GRDIIADSKG..FVLLVALMPME...C..EH.CH.EQ.LMKFQTV....MET-----LPEIRIVVI............T..........PY.DENPRLIERY.RKEFS.RV....AIG......I---ESL.DERIWD.TLSGSGHDHFIY..D.....RCGRLASVIRHPKSdTS...K.FEHTLRALKSAISYAQCGW.CQYDP.P..........DL...PQ..EPVI.T.T-...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------yasftrkgktrrprikavvypqngradtlssdhrstldqer.........................................
W4Z1T3_STRPU/83-177                 .........................................ls---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....-CGQLTYHIPMPYS.AL...R.YPFIQIAIESTYTGRHPCN.CSADE.P..........TT...TA..MPST.-.-E...............KPHKTPSDRKRS....LR..H.AVS...DNN....N......NN--..----.-------.....-----------.....------..----------yyrksgemqsalidrtdad...............................................................
U3K9A0_FICAL/19-264                 ..........................................t-ESQNCQEPPAWRIG.EEDPMWNSRG..SVTVVALLQCS...E..IL.HI.FKkSGSLEDL....RVKLENEGLVNISYVVV............N..........HQ.GAQSQREFHL.LKERV.SD....YIT......VYQQDEQ.QEDVWT.TLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...H.FQYVEESIKIAYCENKCGN.CSYTEpD..........ID...ID.vVCEN.I.TK...............KAGDELSEVEPK....LT..G.QHS...HPNp..hR......HGHH..HRRH.HHHHHHKg...gRGPRRENLQAA.....PEPERR..HPHSGRRH--glfghhrh..........................................................................
F1RD74_DANRE/28-263                 ..........................................s-GSRICKPAPQWEID.GKTPMKELLG..NVVVVALLKAS...C..HF.CL.TQ.AARLGDL....RDKLANGGLTNISFMVV............N..........EQ.DSQSRAMYWE.LKRRT.AQ....DIP......VYQQSPL.QNDVWE.ILEGDKDDFLVY..D.....RCGYLTFHIVLPFS.FL...H.YPYIEAAIRATYHKNMC-N.CSLNA.N..........FS...IS..ESSD.S.TKne..........pagENNQRPNSTEP-....--..-.-VT...AAH....H......HHHQ..QHEP.HHHHNPY.....PNNHKKSGDSD....vTGKPKE..PTHHSHQEH-vhnh..............................................................................
U3JR44_FICAL/27-249                 ...........................................NSSRICHEAPAWTIN.GSSPMEGAAG..QVTVVALLK--...-..-F.CL.RQ.AHSLGGL....RERLARQGTARVRYMIV............N..........EK.APLSRAMLPE.LQRHA.PP....GVP......VLQPEQG.DPDVWQ.VLGGDKDDFLVY..D.....RCGRLAFHIQLPFS.FL...H.FPYVEAAIRYSHIKDFCGN.CSFYP.I..........TT...QE..SNST.-.--...............--VEVPATPSSF....PE..H.EGM...ESE....T......PIHQ..HKPL.HPHHHHE.....---VSSERNTN.....PSENHK..PATHAHHHH-gdh...............................................................................
V8NYH9_OPHHA/29-180                 ...........................................NQTRICQPAPLWKIN.GTEPMAGMEG..Q----------...-..-F.CL.KQ.AASLGSL....QEKLSGDGMANVSFMIV............N..........EK.TPSSRAMYWE.LKRHA.PK....GVP......VFQQQIL.EPEVWQ.ILQGNKDDFLIY..D.....RCRKLTFHIQLPYS.FL...H.LPYVEAAVRYTSRKDYCGN.CSWYY.L..........NS...S-..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------qev...............................................................................
G3UU18_MELGA/1-166                  ...........................................---------------.----------..-----------...-..--.--.--.-------....--------------MII............N..........EQ.APLSRAMFGE.LQRHA.PP....GVP......VLQQQPH.EPDVWQ.LLGGDKDDFLVY..D.....RCGRLAFHIQLPYS.FL...H.LPYVESAIRFTHRKDFCGN.CSLYT.N..........ST...QE..ANST.M.--...............---EVPTTLTPL....PK..Q.EEK...ESE....T......PAHH..QPNHlHPHHHAV.....----GSRTAPE.....PSGDHR..PA-HTHHHH-gahgqlh...........................................................................
U3IXD6_ANAPL/13-195                 ..........................................t-ETQNCQEPPEWRVG.EENPMLNSRG..SVTVVALLQTS...H..NL.SV.LD.HEELEDL....RVKLENEGLVNISYVVV............N..........HQ.GAYSQKKFHL.LKESV.SE....YIT......VYQQDEH.QADVWT.TLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...S.FNYVEEAIKIAYCENKCGN.CSYTE.P..........DI...DA..TCEN.I.TK...............KADEKLAEVEPK....--..-.---...---....-......----..----.-------.....-----------.....------..----------ps................................................................................
A0A0D9RW51_CHLSB/1-190              ...........................................---------------.----------..-----------...-..YL.CI.LQ.ASKLEDL....RVKLEKEGYSNISYIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FSYVEEAIKIVYCEKKCGN.CSLTT.L..........KD...ED..FCKS.V.SL...............ATVDEAVEA---....--..-.PQP...HYH....-......--HE..HHHN.QGHQHLG.....SSKLSENQQPG....aPDAPTH..PAPPDLHHHHkh................................................................................
W4X313_ATTCE/135-288                ..............................vnsdflknngtei---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......IFLQDDP.QSRIWE.RFRASREHAVII..D.....RCGKLTYHVIVPWS.IL...F.FPYVKAAILSTYMDDPCGG.CNPAV.Y..........QA...SN..HENH.V.VEl............tkSTKKDLSTKKDS....SY..R.EID...TKFe.iiW......TTES..LPEN.LTHLHHE.....SSSEEERE---.....------..----------tstassillen.......................................................................
R4GMT5_HUMAN/23-77                  ..........................................d-QSSLCKQPPAWSIR.DQDPMLNSNG..SVTVVALLQAS...C..YL.CI.LQ.ASKLSKM....K----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....--------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------tfvn..............................................................................
W5PG55_SHEEP/23-207                 ..........................................g-QSSYCKQPPAWSIK.DQDPMLNSYG..SVTVVALLQAS...SkhYT.CH.QR.YFRLEDL....RVKLEKEGYSNISYVVV............N..........HQ.EISSRLKYAH.LKNKV.SE....HIP......VYQQEED.QPDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FTYVEDSIKTVYCEDKCGN.CSLKT.Q..........ED...ED..FCKN.V.SL...............ATKEKTAEASQR....H-..-.---...---....-......----..----.-------.....-----------.....------..----------h.................................................................................
V8PHU7_OPHHA/20-55                  ........................................ehq---GRCKEPPEWSIE.EENPMMKSRG..TVTVVALLQAS...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....--------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
E2AE76_CAMFO/129-280                ................................tnlffedsese---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....--I......IFLQDDP.QFRIWE.RFRASKDQVVVI..D.....RCGQLTYQIMVPWS.IL...Y.FPYVKAAILSTHQEDPCGG.CDPTM.Y..........QD...PD..YEDY.F.PN...............-SRSTTKGTDQ-....--..-.---...---....-......----..----.-------.....-----------.....------..----------yetdkinaeliwtteqwssgngsvhleeslkeehetnivppvisdkithds...............................
A0A044QQ64_ONCVO/31-263             .......................................stpi----LCNQTKSWTLD.GQNIVADSKG..FVLLVVLMPMQ...C..EH.CH.KQ.LMKFQTI....MET-----LPEIKIVVV............A..........PY.GANSRLIERY.-R-KE.FS....RIT......I-GMESL.NERIWN.ILSGSAHDHFIY..D.....RCGRLANLIRHPKS.DA...TkSEHTLRALKLAVNYAQCGW.CQYNP.An.......llIS...QK..SIDT.T.YAds...........tlNDKTKKTFIKAV....IY..R.QND...KRH....K......VNSD..RQHD.IAPDHER.....-----------.....------..----------fslrtntispmrkeyertsddhsnqkm.......................................................
E0CX80_MOUSE/23-139                 ..........................................g-QSSACYKAPEWYIG.DQNPMLNSEG..KVTVVALLQAS...C..YL.CL.LQ.ASRLEDL....RIKLESQGYFNISYIVV............N..........HQ.GSPSQLKHSH.LKKQV.SE....HIA......VYRQEED.GIDVWT.LLNGNKDDFLIY..D.....R-------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
B0W3C3_CULQU/144-295                ......................................aagyn---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....-IS......VYPNPLN.ENGTYA.MYGLKEFQVYVL..D.....RCSRIAYIIEPPWS.LI...Q.YSYVKAAVLSTLYDRPCGE.CDVDN.F..........LN...SS..LPVQ.K.MA...............ELQQMPTAKSTS....TT..T.TTT...TTT...eP......SSSS..TS--.-------.....-----------.....------..----------astprsdvrpyddstesdepmateeyseppeptttee.............................................
E0CY03_MOUSE/33-110                 ..........................................g-QSSACYKAPEWYIG.DQNPMLNSEG..KVTVVALLQAS...C..YL.CL.LQ.ASRLEDL....RIKLESQGYFNISYIVV............N..........HQ.GSPSQLKH--.-----.--....---......-------.------.------------..-.....--------------.--...-.-------------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
M4A9J5_XIPMA/5-210                  ...................................vqasrltq---------------.----------..---ITALIQTD...D.kRI.SK.NY.WNNIGRL....RTKLRRSNVTDVSFLIV............N..........EQ.NAVSRALYWE.LKKRA.PT....GVP......VYQQDAN.QTDVWE.VLDGDKDDFLIY..D.....RCGLLTFHVVLPYS.FM...H.NPYVEAAIRATYVGDIC-N.CSAIS.T..........RT...PD..TVQP.P.D-...............EGVDPTEKTQPI....PH..H.YHH...LSS....-......--FF..HHQP.APRNKTQ.....-DQDRPVIFPA.....PYHPHH..AHQH------phhk..............................................................................
Q16FG7_AEDAE/94-251                 ...................................ynkinyde---------------.----------..-----------...-..--.--.-Q.IQLFHNL....FNRFEHNGYRNVQFILG............Aap......srHP.DETEFTEFEDfLDNVT.SVaagyNIS......VYPNPLN.ENGTFA.MFGLKEFQVYVV..D.....RCSRISYIIEPPWS.LI...Q.YSYVKAAVLSTMYDRPCGE.CDVDN.F..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------lnaslpekkldqfimlpalnvteta.........................................................
M3XHZ2_LATCH/1-183                  ..........................................m---------------.----------..-----------...-..--.--.-Q.AARLGSL....HEKFARKGMEDIRYLIV............N..........NK.SPSSRAMFWE.LKRHA.PA....NIT......VYQQAPL.QKNVWQ.ILEGKKDDFFIY..D.....RCGKLTFQISLPFS.FL...N.NSYVEAAIMSTYHSDKCGN.CSAANfN..........QT...VQ..VGSN.T.SV..............sAWEESGKEGLGQ....N-..-.---...---....-......----..----.-------.....-----------.....------..----------kqsvedyiqhplarldplpslpppphrhlhkrhqrfpeae..........................................
SEPP1_MOUSE/23-268                  ..........................................g-QSSACYKAPEWYIG.DQNPMLNSEG..KVTVVALLQAS...U..YL.CL.LQ.ASRLEDL....RIKLESQGYFNISYIVV............N..........HQ.GSPSQLKHSH.LKKQV.SE....HIA......VYRQEED.GIDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEERCGN.CNLTS.L..........ED...ED..FCKT.V.TS...............ATANKTAEP---....--..-.SEA...HSH....-......--HK..HHNK.HGQEHLG.....SSKPSENQQPG.....PSETTL..PP-SGLHHHHrhrgqhrqghlesudttaseglh...........................................................
F4X476_ACREC/178-323                ...............................vnsdflknnete---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....--I......IFLQDDP.QSRIWE.RFRASREHAVII..D.....RCGMLTYHVIVPWS.IL...F.FPYVKAAILSTYMDDPCGE.CNPAV.Y..........RA...SN..HEDH.V.VE...............LTKSTKKELNPS....YR..E.VDT...KFEi..iW......TTES..LPEN.LTHLHYE.....-----------.....------..----------ssseeeretsiassi...................................................................
A0A087XRM9_POEFO/1-178              ...........................................-----CQPPSTWMIG.EVEPMKGTAG..QVTVVALLKEI...L.gEH.PL.TQ.AARIDGL....RQKLETQGLNDVVYMVI............N..........HQ.GEQAQRLHPM.LAERL.SD....KIS......LYKQGEQ.QPDVWQ.ALNGKKDDFIIY..DslcnlRCGRLTHHISLPYS.VI...G.HGHIESAIKEAYCNRMCGA.CSHES.Q..........TA...ETseGCRA.T.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------pnaqpead..........................................................................
J0XLE8_LOALO/31-255                 .......................................stpi----LCSQTKPWKLS.GRDIVSDSKG..LVLLVVLMPME...C..EH.CH.KQ.LMKFQTV....MET-----LPEIRIVVV............A..........PH.DENPRLIERY.-REEF.P-....RVA......I-GMESL.DERIWN.TLSGSAHDHFIY..D.....RCGRLASIIRHPESdTS...K.FEHTLWALKLAISYAQCGW.CQYDP.P..........DL...PS..PHKP.L.VT...............THASSTH-----....--..-.---...---....-......----..----.-------.....-----------.....------..----------kgktkrprikavmypqngrtrmvssdrqadfapdherfssrtntvsparkgharis..........................
M3YSM4_MUSPF/1-167                  ..........................................m---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.---------N.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGKKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEEKCGN.CSLTT.L..........EA...KD..FCEM.V.SS...............PTVGNTTEAPQP....HH..H.HHH...HHH....H......LHHH..HHHK.HGHQHHG.....NKELSESQRPE....aPDAAEY..PAPEGLHQHHkhkthqrqghp.......................................................................
F7EK34_ORNAN/12-166                 ..........................................n-GTRICQPAPRWTVN.GVAPMEGTEG..QVIVVALLKAR...S..FF.CA.LP.SAYLAGL....RERLAGHGAGNVSFLIV............N..........QR.DPTAQLLHTE.LERHA.PP....GVP......VYAQDGP.DPDVWS.VLGGDKDDFFVY..D.....RCGRLTFHIQLPFS.FL...H.FPYVEAAVRFTHRRDFCGN.CSY--.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
R4GJB1_CHICK/1-203                  ...........................................---------------.----------..-----------...-..HF.CL.LQ.ARSLGAL....RERLGQQGVSDVRYVIV............N..........EQ.APLSRAMFGE.LQRHA.PP....GVP......VLQQQPH.EPDVWQ.LLGGDKDDFLVY..D.....RCGRLAFHIQLPYS.FL...H.LPYVESAIRFTHRKDFCGN.CSLYP.N..........ST...QE..ANST.M.E-...............----VPATLTPL....PK..Q.EEK...ESE....T......PAHH..-QPN.HLHPHHR.....--AVGNGTAPE.....PSGDHR..PA-HAHHHH-gahgklhpkgqtpegrd.................................................................
J9NST4_CANFA/1-138                  ..........................................m---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.---------Y.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGKKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKRAYCEEKCGN.CSLTV.L..........ED...EE..VCKM.V.SS...............GTVESTTEAPQP....HP..H.DHH...LH-....-......---H..HHHH.HHHKHHD.....-----------.....------..----------kftstyqafkalkch...................................................................
G3TLW1_LOXAF/23-207                 ..........................................v-QSSFCKQPPAWKIR.EEDPMLNSIG..SVTVVALLQAS...RknYT.CL.QR.TCQLEDL....RVKLEKEGYSNVSYVIV............N..........HQ.DLNSRLKYIH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEAAIKIVYCEEKCGN.CSLMT.P..........ED...ED..FCKK.V.SS...............VNVEDTAEASKP....H-..-.---...---....-......----..----.-------.....-----------.....------..----------h.................................................................................
SEPP1_BOVIN/23-290                  ..........................................g-QSSYCKQPPPWSIK.DQDPMLNSYG..SVTVVALLQAS...U..YL.CI.LQ.ASRLEDL....RVKLEKEGYSNISYVVV............N..........HQ.GISSRLKYVH.LKNKV.SE....HIP......VYQQEEN.QPDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FTYVEDSIKTVYCEDKCGN.CSLKA.L..........ED...ED..VCKN.V.FL...............ATKEKTAEASQR....HH..H.PHP...HSHp..hP......HPHP..HPHP.HPHPHHGhqlheNAHLSESPKPD....tPDTPEN..PPPSGLHHHHhrhkgpqrqghsdncdtpvgseslqps.......................................................
A7RTX8_NEMVE/23-190                 .........................................es--AGVCQRPRPWTVN.GMDPMAQARAdkQIVVLALMEAR..aC..GI.CV.RQ.AKAMESLltmlRQRERSYQLGNLSFMIV............N..........HH.MAAGSIRF--.IEGRV.S-....-FP......VYQ-ENA.NKQIWP.AVDGAKDDIIVY..D.....RCGGLVSHLKWPKS.DL...T.KPHLWQAIQRAKWSKAC--.CKQQT.T..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------epptisdggk........................................................................
F4X476_ACREC/858-966                ........................................itl---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....-CGMLTYHVIVPWS.IL...F.FPYVKAAILSTYMDDPCGE.CNPAV.Y..........RA...SN..HEDH.V.VE...............LTKSTKKELNPS....YR..E.VDT...KFEi..iW......TTES..LPEN.LTHLHYE.....-----------.....------..----------ssseeeretsiassi...................................................................
H2UNP3_TAKRU/23-253                 ..........................................g-DGPRCQLPPVWKIG.DLEPMKEAMG..RVTVVALLESS...W..LS.DF.LH.LGRMDSL....RQRLENQGLRDVVYMVV............S..........HQ.GAHAPGLHAM.LAQKL.TE....HIS......LYKQDEA.LPDVWQ.TLGGNNNDFFIY..D.....RCGRLTHRISLPYS.II...G.HGHVERAVKDTYCNSLCGE.CTHET.T..........ET...LQ..ECTP.K.TS...............ALPDNGVAPGAE....E-..-.TGH...ECH....H......HGRQ..HHGD.GHRDHGD.....-SQCTHTRGSG.....RGHGHH..HGHGGQGQH-eg................................................................................
A0A077ZBY8_TRITR/1-193              ........................................mep---TTCQPAPPITHN.SNLIMANYAG..YVTLIALIELQ...C..NF.CR.SQ.INSLLKL....SQLFKENYDEPTKFVIV............A..........PL.NESSMFVHYY.REYLL.PY....KFD......VI-QETA.AELIWN.PLGGGKFDFFVY..D.....RCGRLNYYIPYPQS.FM...Y.YHYTISSLHSTHRHQRCGP.CPIHL.I..........SE...KG..NNK-.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------vaeqtfansvifkvelgqadlnlagsdhy.....................................................
H3DGX7_TETNG/23-251                 ..........................................g-DGPRCQLPPTWKIG.DLEPMTGAMG..RVTVVALLDAR...S..TI.DF.LN.LGRMDSL....RQKLENQGLRDVVYMVV............N..........HQ.GAQARGLHAM.LAQRL.SE....HIS......LHRQDEA.LADVWQ.TLGGNKDDFFIY..D.....RCGRLTHRISLPYA.VI...G.HGHVEKAVKDTYCSSLCGE.CTHET.A..........ET...QQ..ECTP.K.T-...............--DTQPQED---....TR..H.ECH...HRH....H......QGHQ..HHGD.GHRDHGD.....-NQCTHTQGSG.....PGHDHG..HGHHGGQGHHqgh...............................................................................
F6PUF8_HORSE/23-250                 ..........................................g-QSSFCKQPPAWSIR.DQDPMLNSYG..SVTVVALLQAS...C..YL.CL.LQ.ASRLEDL....RVKLEKEGYSNISYVVV............N..........HQ.EISARLKYIH.LKNKV.SE....YIA......VYQQEEN.QTDIWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEKKCGN.CSLMT.L..........ED...ED..FCKT.L.SL...............ATVEKTTED---....-S..Q.PHH...HHH....-......--HQ..HHHK.HGHQHVG.....NSQLSENQQPE....aTGAPEH..PPPPGLHHHHk.................................................................................
G5APA7_HETGA/37-233                 .............................plvklneiihlmhf---------------.----------..-----------...-..--.-F.PK.YLRFEDL....RVKLEKEGYSNISFVIV............N..........HQ.GSNSRLKYIQ.LKNQV.SD....HIP......VYQQEEH.QTDVWS.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...S.FPYVEEAIKIAYCEEKCGN.CSLRT.L..........ED...ED..FCKN.V.SL...............ATVEKTAEA---....--..-.--P...HPH....-......--NK..QHHK.HGHQHLG.....GSELSDNKQPE....aPDNPVL..S-PLGHHHHHe.................................................................................
J9FD25_WUCBA/10-174                 eqlmkfqtvmetlseirivviapydenprlieryrkefsrvti---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......--GMESL.DERIWD.TLSGSGHDHFIY..D.....RCGRLASVIRHPKS.DT...SkSEHTLRALKSAISYAQCGW.CQYDP.P..........DL...PQ..EPVI.T.TY...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------asltrkgktrrpmavvekeadtleqfssnwflegaqfenrrnqs......................................
M4ANC2_XIPMA/23-205                 ..........................................g-GGPRCQPPPTWMIG.EVEPMKGTAG..QVTVVALLQAT...L..RL.QI.LS.NQRIDGL....RQKLETQGLNDVVYMVI............N..........HQ.GEQAQRLHPL.LAQRL.SD....KIS......LYKQGEQ.QPDVWQ.TLNGKKDDFIIY..Ds...lRCGRLTDHISLPYS.VI...G.HGHIESAIKEAYCNRKCGA.CSHET.A..........ET...PE..ECRA.T.PN...............AQ----------....--..-.---...---....-......----..----.-------.....-----------.....------..----------pdadtpaavg........................................................................
F1N9T1_CHICK/1-159                  ...........................................---------------.----------..-----------...-..-L.CL.LQ.ASRLEDL....RVKLENEGLVNISYVVV............N..........HQ.SPHSQKKFHL.LQESV.SD....HIT......VYQQDDH.QADVWT.TLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...S.FQYVEEAIKIAYCENNCGN.CSYTE.P..........DI...DN..ICEN.I.TK...............K---EGIEPEPE....PS..G.QHS...HHH....H......QLHR..HRHH.H------.....-----------.....------..----------..................................................................................
H3DJR4_TETNG/1-201                  ...........................................---------------.----MEALVG..RVVVVALLKAS...T..PP.CD.AP.FPRIGPL....REKLSRRNVTEVSFVIV............N..........EQ.EPVSRALYWQ.LRRRA.PP....GVP......VYQQAPL.QDDVWE.ALDGDKDDFLIY..D.....RCGQLTFHIGLPYS.SL...R.YTYVEAAVIATYQGNIC-N.CSANC.H..........IS...EH..QQQQ.R.K-...............-WRDAQSDQPDG....HC..G.DRW...STH...yP......PPPS..PSPP.ATHTHTD.....-----------.....------..----------arpshthtsldlpppp..................................................................
E0CZC5_MOUSE/23-177                 ..........................................g-QSSACYKAPEWYIG.DQNPMLNSEG..KVTVVALLQAS...C..YL.CL.LQ.ASRLEDL....RIKLESQGYFNISYIVV............N..........HQ.GSPSQLKHSH.LKKQV.SE....HIA......VYRQEED.GIDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FPYVEEAIKIAYCEERCGN.CNL--.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
H2PXQ5_PONAB/1-188                  ...........................................---------------.----------..-----------...-..YL.CI.LQ.ASKLEDL....RVKLKKEGYSNISYIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FPYVEEAIKIAYCEKKCGN.CSLTT.L..........KD...ED..FCKS.V.SL...............ATVDKTVEA---....--..-.PSP...HYH....-......--HE..HHHN.HGHQHLG.....SSELSENQQPG....aPDAPTH..PAPPGLHHHH..................................................................................
H3CE96_TETNG/6-134                  .lfmvylrsgmwslliyciywhlklglsdevdnceslhlgqyl---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.------------..-.....--------------.--...-.----------------CNE.PRIDEaT..........QE...PE..NCKD.M.IA...............WGETRSRSKNQK....TH..EdTHT...HTH....T......HTHT..HTHT.HTHTHTH....tHQPVNLQLHTSt...nSQAKQH..----------palgyrcr..........................................................................
G1Q9G6_MYOLU/23-202                 ..........................................g-QSPFCKPPPAWITL.VYVFIRYPH-..--STASLLKKT...Y..YF.CL.RQ.ASSLEDL....RVKLEKEGFSNISYVVV............N..........HQ.GHPSRLRYNL.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGNKDDFLIY..D.....RCGRLVYHLGLPFS.IL...E.FPYVEQAIKIAYCEEKCGN.CSLTT.L..........ED...ED..FCKN.M.SL...............ATVRKTTEASEP....H-..-.---...---....-......----..----.-------.....-----------.....------..----------h.................................................................................
F6Q9N1_XENTR/23-205                 ........................................ghr---KRCKEPPEWSIG.DQNPMMQSAG..KVTVVALLQAS...R..HQ.CL.G-.-FRLEDL....RLKLEKEKLVGISYVVV............N..........HQ.GRQSRAKYDL.LKSKV.SE....HIP......VYQQEEY.QPDVWS.LLKGDKDDFFVY..D.....RCGRLVQHLELPYS.LL...H.FPYVEEAIRIAYCEDKCGE.CEHKK.P..........EE...QQ..EQDK.P.VE...............EKVERPRHHRNH....H-..-.---...RH-....-......----..----.-------.....-----------.....------..----------h.................................................................................
I3JR88_ORENI/1-180                  ...........................................---------------.----------..-----------...-..--.--.--.-------....--------------IIV............N..........ER.DAHSRAMYWE.LKRSA.PT....GVP......VFQQQPF.QNDVWE.ALDGDKDDFLVY..D.....RCGLLTFHIVMPYS.FL...H.HPFVEAAIRATYQKNIC-N.CTQNF.T..........SSvggNN..ITNN.G.TA...............QLVDEGSEVPDT....AS..G.RTH...HHH....H......HHHH..HDDP.PSHHHHH.....-DQHSSHQNQS.....LHQQDQ..GDSTSHHHHHsphqqhqhdh........................................................................
D6RIS9_HUMAN/23-209                 ..........................................d-QSSLCKQPPAWSIR.DQDPMLNSNG..SVTVVALLQAS...C..YL.CI.LQ.ASKLEDL....RVKLKKEGYSNISYIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FPYVEEAIKIAYCEKKCGN.CSLTT.L..........KD...ED..FCKR.V.SL...............ATVDKTVETPSP....HY..H.HE-...---....-......----..----.-------.....-----------.....------..----------h.................................................................................
W5KEM0_ASTMX/23-259                 ..........................................g-DGARCKPPAVWKIG.DVEPLKDSLG..QVTVVAFLQKT...K.wVL.DD.LT.LDRLDSL....RLKLEKAGYANITYLVV............N..........SQ.DENSRRLHSL.LEQRL.SA....NIT......LYGQEPD.AQDIWQ.IANVMKDDFQIY..D.....RCGRLTHHLSLPYT.IL...S.GPHVEEAIRNTYCDRTCGE.CSMES.S..........IQ...PQ..ECNG.T.V-...............--EEKPVVEEEE....VG..R.GHHg.gGHHs..gH......HGGH..HGGH.HGGHHGG.....HHGGHHSGHHG.....HHGDHG..GQQRGHHDQHtd................................................................................
A0A088AAX3_APIME/26-230             ...................................qcratnlr---------------.-----KDQLG..HVNVFAFLDPS...W..NY.SY.RQ.AVMLELL....KKQLEKSGFSNILLFMVarpsdlpeddteNsmeikawleiSK.NIQESEHFLS.LDKMI.FS....DIAkekkgiIFLQDTF.ELGIWK.SFRASKDEVIII..D.....RCGKITYQIIVPWS.IL...Y.FPYVKAAILSTYKDDPCGP.CYEQS.S..........II...RE..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------sidyrdyllktinsekkkinknldirp.......................................................
A0A096MFI7_POEFO/5-209              ................vqasrltqitsliktdgerifhngsfl---------------.----------..-----------...-..--.--.--.-LNIGRL....RTKLRRSNITDVSFVIV............N..........EQ.DAASRALYWE.LKKRA.PT....GVP......VYQQAAN.QTDVWE.VLDGDKDDFLIY..D.....RCGLLTFHVVLPYS.SL...Q.NPYVEAAIRATYLGDIC-N.CSAIS.T..........RT...PS..IQGT.I.Q-...............TPDEGADPTEET....QT..I.PHH...YHH....H......FSFS..HHQP.APRDKSQ.....D-QHRS-----.....------..----------aifpapyhphhah.....................................................................
C3YH40_BRAFL/68-195                 ........................................ggl---------------.----------..-----------...-..--.--.--.-------....-QKLYSEGKSDIFFGAV............N..........HW.GWASWWYRGE.LERRA.--....NFP......VYQ-DSW.SQDIWG.KLHAAKDDILVY..D.....RCGRLAYHLRLPRA.YL...G.NTHTEEAIRAAYRQSPCGP.CGTLA.G..........ET...AT..PCF-.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------trlsvirlkisqlh....................................................................
A0A093BFN6_CHAPE/1-116              ...........................................---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.-----KDDFLIY..D.....RCGRLVYHLGLPYS.FL...T.FQYVEDSIKVAYCENKCGN.CSYME.P..........DI...DD..ICEN.I.TK...............KADEKLAELEPS....PT..G.QHS...HQQ...nW......NRHR..HHHG.KGSHHSK.....T------ENHQ....aPSGAHR..HP--------hsg...............................................................................
SEPP1_HUMAN/23-249                  ..........................................d-QSSLCKQPPAWSIR.DQDPMLNSNG..SVTVVALLQAS...U..YL.CI.LQ.ASKLEDL....RVKLKKEGYSNISYIVV............N..........HQ.GISSRLKYTH.LKNKV.SE....HIP......VYQQEEN.QTDVWT.LLNGSKDDFLIY..D.....RCGRLVYHLGLPFS.FL...T.FPYVEEAIKIAYCEKKCGN.CSLTT.L..........KD...ED..FCKR.V.SL...............ATVDKTVET---....--..-.PSP...HYH....-......--HE..HHHN.HGHQHLG.....SSELSENQQPG....aPNAPTH..PAPPGLHHHHkh................................................................................
H0UZB3_CAVPO/1-141                  ...........................................---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.SD....HIS......VYQQEQH.QPDIWS.RLKGNKDDILIY..D.....RCGRLAYHLRMPYS.FL...S.FPYVEQAIKIVYCVEKCGN.CSLKN.L..........ED...DD..FCKN.V.SL...............AA--VTTEAPQK....HH..H.RQI...HPP....K......RGHP..----.-------.....-----------.....------..----------ylgsrepeapdnpvqslplglhnlhrgqprqvh.................................................
E5SI43_TRISP/46-261                 ........................................dep---DICHPVPMFTNG.GQLVMTNYHG..HVTLIALMELQ...C..TL.CR.TQ.ISSIVKL....SELFRENYDEPTKFLVV............A..........PH.NESDRFV-EY.YKQYLkPY....DIG......VI-QETT.AEPIWH.TLRGSRFDFFVY..D.....RCGRLNYYIPYPQS.FM...Y.YHYTISSLHSTHRYIKCGP.CPSNR.Q..........DI...ST..AAVS.V.GKt.............lTDDGQWNSNDQR....ST..F.PSE...---....-......----..----.-------.....-----------.....------..----------tssvykhhlpkyqpkyirglsgdptgen......................................................
A0A096M0U7_POEFO/1-106              ..........................................l---------------.----------..-----------...-..-F.CL.VQ.ASRIDGL....RQKLETQGLNDVVYMVI............N..........HQ.GEQAQRLHPM.LAERL.SD....KIS......LYKQGEQ.QPDVWQ.ALNGKKDDFIIY..DslcnlRCGRLTHHISLPYS.VI...G.HGHIE--------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
I3LJP2_PIG/5-135                    ........................................yyy---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-------.------.----------YY..F.....RCGLLVYHLGLPYS.FL...T.FPYVEEAIKTVYCENKCGN.CSLKT.L..........KD...ED..FCKN.V.YL...............ATEEKTTEAPQP....HH..H.HDH...HHH....-......--RH..HHHH.HGHQHLG.....NGHLSEHPKPE....aPDTPEQ..PPPSGLHHHHghkghqrqgh........................................................................
B7Q2F3_IXOSC/1-206                  ..........................................m---------------.----------..-----------...-..--.--.FQ.IISLEAL....LLKLRARNLSDVQFLVV............N..........SL.D--SAAEVRQ.LERRV.S-....-FP......VYQ-ETA.DEPVWS.VLEGDKDDVFIY..D.....RCGRLSYFIPFPLS.VMlpgR.HPVVEEALNTTYYASPCGDfCPQDP.S..........AT...PH..RSS-.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------phehqqripgeiavqdggepgttvsppttpseglgwrvihmvfgdghqgqvdshtpshareggvttgaphdhqerqptpmec
H2MB78_ORYLA/1-159                  ...........................................---------------.----------..-----------...-..--.--.--.-------....--------------MIV............N..........EL.EALSQTMHWK.LKKKA.PT....GVP......VYQQSSL.QKDVWE.ILDGDKDDFLIY..D.....RCGLLTFHIVLPNS.FL...Q.NADVENAITATYTQDIC-N.CSGNS.TlsgggnnftrN-...SS..----.-.-Qshsgvq...rpadepENVTTTLEASPN....DS..R.HEH...AHH....H......HPHH..QHLH.HHHPHHQ.....-----------.....------..----------hlh...............................................................................
SELPA_DANRE/23-255                  ..........................................t-EGARCKLPPEWKVG.DVEPMKNALG..QVTVVAYLQAS...U..LF.CL.EQ.ASKLNDL....LLKLENQGYPNIAYMVV............N..........NR.EERSQRLHHL.LQERL.L-....NIT......LYAQDLS.QPDAWQ.AVNAEKDDILVY..D.....RCGRLTYHLSLPYT.IL...S.HPHVEEAIKHTYCDRICGE.CSLES.S..........AQ...LE..ECKK.A.T-...............EEVNKPVEEEPR....QD..H.GHH..eHGHh..eH......QGEA..ERHR.HGHHHPHh...hHHHHRGQQQVD.....------..----------vdqqvlsqvdfgq.....................................................................
K7E6A4_MONDO/1-186                  ...........................................---------------.----------..-----------...-..--.--.--.---MGSL....QERLARMGAPDVRFIIV............N..........EK.SPQSRALHGE.LELHA.PP....GVP......VYGQPEL.GPDIWS.ILGGAKDDFLIY..D.....RCGRLTFHIRLPFS.FL...H.FPYVESAIRFTHRQDSCGN.CSFYP.A..........QV...NS..TDER.K.GEskhs.......pgleG-----------....--..-.---...---....-......----..----.-------.....-----------.....------..----------egqeplgekpdsrgltlgssaptahahdpvhggmekpspslpspalepslhege............................
K7JYM3_NASVI/162-308                .....................................lgpdvy---------------.----------..-----------...-..--.--.--.-------....-----------------............-..........--.----------.-----.--....---......-FIQDND.ELQIWS.KLRAFRDQILVI..D.....RCGRLTYQVIVPWS.IL...H.FPYVKAAILSTYKDEPCGY.CQFKE.T..........VF...DT..TSTDnK.DA...............QSSSKLVEQTED....ND..N.P--...---....-......----..----.-------.....-----------.....------..----------stlsqetttviyeaesydttltvdessspivqtehevtslstsdrn....................................
W5M4W3_LEPOC/1-173                  ..........................................m---------------.----------..-----------...-..--.--.--.-------....---------TDVGFLIV............N..........ER.EPVSRAMFWE.LKRRA.PE....GIP......VYQQGLF.QSDVWE.ILEGEKDDFLIY..D.....RCGLLTFHIVLPYS.FL...H.YPYVEAAIRATYLRDICGN.CTLDS.S..........DN...QG..LNAS.Q.IP...............ERKENVTDAECL....DD..H.EQH...QGE....Q......SNGP..QPSR.HSQAHHS.....GHRLVHGPCRD.....KGRKRP..P---------spqnstl...........................................................................
W5MN70_LEPOC/1-198                  ...........................................---------------.----------..-----------...-..--.--.--.---LDVL....RLRLEQQGLVNISYVVV............N..........HQ.GEQSHRLYPV.LKKKM.SQ....KIR......VYDQDPL.QEDVWK.ILSGEKDDFLIY..D.....RCGSLTHHLGLPYS.ML...T.MSYVEDAIRDTYCKDICGN.CSLES.S..........SL...PV..TCNS.T.VKp............egKPEDKPEESPES....HG..H.PHA...HGHg..hHhseegrQSHR..RHSS.HGHHHGH.....GRHHHGSQQEF.....NNGQTQ..RHSQTHQQQ-q.................................................................................
SELPB_DANRE/28-263                  ..........................................n-GSRICKPAPQWEID.GKTPMKELLG..NVVVVALLKAS...U..HF.CL.TQ.AARLGDL....RDKLANGGLTNISFMVV............N..........EQ.DSQSRAMYWE.LKRRT.AQ....DIP......VYQQSPL.QNDVWE.ILEGDKDDFLVY..D.....RCGYLTFHIVLPFS.FL...H.YPYIEAAIRATYHKNMC-N.CSLNA.N..........FS...IS..ESSD.S.TK...............NDPAGENNQRPN....ST..E.PVT...AAH....H......HHHQ..QHEP.HHHHHNP....yPNSHKKSGDSD....vTGKPKE..PPHHSHQEH-vhn...............................................................................
I3KDC0_ORENI/1-102                  ..........................................l---------------.----------..-----------...-..-F.CL.VQaSSRLDGL....QQKLERQGLKNVVYMVV............N..........HQ.GEQSRHLHPL.LEAKL.SK....NII......LYKQDGH.QPDVWQ.TLAGEKDDFFIY..D.....RCGRLTYRISLPYS.II...G.EGHIE--------------.-----.-..........--...--..----.-.--...............------------....--..-.---...---....-......----..----.-------.....-----------.....------..----------..................................................................................
A0A096M1E4_POEFO/1-185              ...........................................---------------.----------..-----------...-..HF.CL.VQ.ASRIGRL....RTKLRRSNITDVSFVIV............N..........EQ.DAASRALYWE.LKKRA.PT....GVP......VYQQAAN.QTDVWE.VLDGDKDDFLIY..D.....RCGLLTFHVVLPYS.SL...Q.NPYVEAAIRATYLGDIC-N.CSAIS.T..........RT...PS..IQGT.I.Q-...............TPDEGADPTEET....QT..I.PHH...YHH....H......FSFS..HHQP.APRDKSQ.....D-QHRS-----.....------..----------aifpapyhphhah.....................................................................
U3KMC5_RABIT/1-197                  ...........................................---------------.----------..-----------...-..YL.CI.LQ.ASRLEEL....RVKLEKEGYSNISYVVI............N..........HQ.GIDSQLKYIH.LKNKV.SH....HIL......VYQQEEN.QTDVWT.LLKGSKDDFLIY..D.....RCGRLVYHLALPYS.FL...T.FPYVEEAIKIAYCEETCGN.CSLMT.P..........ED...ES..FCKN.V.SL...............ATVEKVSEA---....--..-.LRP...HHH....-......--HT..HHHK.HGHQHLD.....SSELSEKQHPG....tPDAPLH..LPPSGLHHHHkhrdqhrqg.........................................................................
H2ZVW4_LATCH/23-227                 ..........................................g-KSTRCKEPPTWYIG.EENPMLESRG..KVTVVALLQAS...S..FY.II.LY.VSRMDDL....HLKLENEGLVNISYMIV............N..........HQ.GEYSQHKHNL.LKQRV.SE....FIP......VYKQDME.KPNVWN.LLNGNKDDFLIY..D.....RCGRLVYHLGLPYS.VL...H.FPYMEEAIRIAFCETRCGN.CSFTV.K..........DI...NE..ICNR.T.E-...............-NTDEPVEEPPP....TS..V.PDP...PQQnpqhH......GAHR..HHRQ.HGH----.....-----------.....------..----------q.................................................................................
G3WG53_SARHA/1-198                  ...........................................---------------.----------..-----------...-..YL.CI.LQ.ASRLEDL....RVKLEREGFSNISYIVV............N..........HQ.GNPSQLNFKE.LKDKV.SE....NIT......VYQQEVN.QQDVWT.VLNGSKDDFLIY..D.....RCGRLVYHLGLPYT.FL...T.FSYVEEAIKVAYCEKSCGN.CSYTT.I..........DD...ES..FCKN.A.SS...............VAEEEPTRTPTS....HP..P.HHH...LRH....H......HDHH..HHHH.HHQHHRH.....GHQPTENKKPE.....DSETAAdvHSAQGLHHHH..................................................................................
#=GC seq_cons                       ...................................................................................................phtsL....p.+Ltppsh.sltahlV............N..........cp.s..Sphha...Lcpph.s.....tls......VYpQ-t..p.DlWp.hLsGsKDDFLIY..D.....RCGRLsaHlsLPaS.hL...p.asYVEtAI+hsYpcchCGs.Cohps............ps....p...spt.h.....................pt..t...........................................................................................t.................................................................................
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