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Database: Pfam
Entry: Ser_hydrolase
LinkDB: Ser_hydrolase
Original site: Ser_hydrolase 
#=GF ID   Ser_hydrolase
#=GF AC   PF06821.10
#=GF DE   Serine hydrolase
#=GF PI   DUF1234;
#=GF AU   Vella Briffa B, Eberhardt R
#=GF SE   Pfam-B_4941 (release 10.0)
#=GF GA   20.60 20.60;
#=GF TC   20.60 20.60;
#=GF NC   20.50 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20080647
#=GF RT   RBBP9: a tumor-associated serine hydrolase activity required for
#=GF RT   pancreatic neoplasia.
#=GF RA   Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS,
#=GF RA   Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF,
#=GF RA   Cheresh DA;
#=GF RL   Proc Natl Acad Sci U S A. 2010;107:2189-2194.
#=GF RN   [2]
#=GF RM   15159570
#=GF RT   Harvesting the high-hanging fruit: the structure of the YdeN
#=GF RT   gene product from Bacillus subtilis at 1.8 angstroms resolution. 
#=GF RA   Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys
#=GF RA   A, Minor W, Joachimiak A, Derewenda ZS; 
#=GF RL   Acta Crystallogr D Biol Crystallogr 2004;60:1101-1107.
#=GF RN   [3]
#=GF RM   19004028
#=GF RT   Crystal structure of human retinoblastoma binding protein 9.
#=GF RA   Vorobiev SM, Su M, Seetharaman J, Huang YJ, Chen CX, Maglaqui M,
#=GF RA   Janjua H, Proudfoot M, Yakunin A, Xiao R, Acton TB, Montelione
#=GF RA   GT, Tong L;
#=GF RL   Proteins. 2009;74:526-529.
#=GF DR   INTERPRO; IPR010662;
#=GF DR   SCOP; 1uxo; fa;
#=GF CC   Members of this family have serine hydrolase activity. They
#=GF CC   contain a conserved serine hydrolase motif, GXSXG/A, where the
#=GF CC   serine is a putative nucleophile [1].                         
#=GF CC   This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic
#=GF CC   members of this family have a conserved LXCXE motif, which binds
#=GF CC   to retinoblastomas. This motif is absent from prokaryotic
#=GF CC   members of this family [3].
#=GF SQ   458
#=GS W0A8Y9_9SPHN/1-156        AC W0A8Y9.1
#=GS G0A9Z4_COLFT/13-174       AC G0A9Z4.1
#=GS A1TI82_ACIAC/9-178        AC A1TI82.1
#=GS A6VL16_ACTSZ/5-180        AC A6VL16.1
#=GS Q49XP4_STAS1/4-181        AC Q49XP4.1
#=GS B9JGU1_AGRRK/4-172        AC B9JGU1.1
#=GS K7SGL0_GLUOY/44-214       AC K7SGL0.1
#=GS D5CTN5_SIDLE/5-173        AC D5CTN5.1
#=GS A0A024HH43_PSEKB/9-184    AC A0A024HH43.1
#=GS B0VTL2_ACIBS/1-158        AC B0VTL2.1
#=GS F7BWC2_MONDO/7-182        AC F7BWC2.1
#=GS B8C4I3_THAPS/6-185        AC B8C4I3.1
#=GS D0J7T8_COMT2/7-172        AC D0J7T8.1
#=GS W8QWY0_PSEST/8-180        AC W8QWY0.1
#=GS A4GAH7_HERAR/1-152        AC A4GAH7.1
#=GS C5B0Z7_METEA/8-178        AC C5B0Z7.1
#=GS C9YWL2_STRSW/13-194       AC C9YWL2.1
#=GS Q2K7Y0_RHIEC/8-177        AC Q2K7Y0.1
#=GS A6Q6J4_SULNB/4-175        AC A6Q6J4.1
#=GS R6CXD5_9CLOT/4-188        AC R6CXD5.1
#=GS I0HS92_RUBGI/12-176       AC I0HS92.1
#=GS Q0SA54_RHOJR/11-186       AC Q0SA54.1
#=GS Q04HK8_OENOB/3-165        AC Q04HK8.1
#=GS D8TT31_VOLCA/7-187        AC D8TT31.1
#=GS A7S2A5_NEMVE/6-179        AC A7S2A5.1
#=GS J9VZD2_LACBU/3-179        AC J9VZD2.1
#=GS J7QR58_METSZ/8-176        AC J7QR58.1
#=GS D0LLH6_HALO1/4-184        AC D0LLH6.1
#=GS D8PJ59_9BACT/13-181       AC D8PJ59.1
#=GS F8J6U0_HYPSM/8-188        AC F8J6U0.1
#=GS B2JKH1_BURP8/13-177       AC B2JKH1.1
#=GS A0A098GIC8_TATMI/5-179    AC A0A098GIC8.1
#=GS C6W7B3_DYAFD/5-175        AC C6W7B3.1
#=GS D5AKW9_RHOCB/4-169        AC D5AKW9.1
#=GS G7M0W0_9CLOT/6-185        AC G7M0W0.1
#=GS A0A089PPN3_PLUGE/6-184    AC A0A089PPN3.1
#=GS E8SJN4_STAPH/4-178        AC E8SJN4.1
#=GS B9JJE4_AGRRK/4-173        AC B9JJE4.1
#=GS D3UZE3_XENBS/17-196       AC D3UZE3.1
#=GS A0A089WHC4_9PSED/8-180    AC A0A089WHC4.1
#=GS Q12HE8_POLSJ/6-175        AC Q12HE8.1
#=GS A0A096N5C2_PAPAN/7-183    AC A0A096N5C2.1
#=GS B7G378_PHATC/3-178        AC B7G378.1
#=GS G8NVG2_GRAMM/5-173        AC G8NVG2.1
#=GS A2DEF7_TRIVA/6-186        AC A2DEF7.1
#=GS C6RL02_ACIRA/4-183        AC C6RL02.1
#=GS B5HBV0_STRPR/9-188        AC B5HBV0.1
#=GS A5VHW5_LACRD/4-177        AC A5VHW5.1
#=GS Q146K7_BURXL/13-177       AC Q146K7.1
#=GS A0A0D5VH52_9BURK/9-184    AC A0A0D5VH52.1
#=GS K4QU97_9ACTN/9-188        AC K4QU97.1
#=GS C3KS07_RHISN/4-173        AC C3KS07.1
#=GS A0A0B5HRF9_9ARCH/194-377  AC A0A0B5HRF9.1
#=GS I0DWB4_PROSM/16-195       AC I0DWB4.1
#=GS F6A8Q3_PSEF1/8-180        AC F6A8Q3.1
#=GS B4ET83_PROMH/6-185        AC B4ET83.1
#=GS A9BQJ5_DELAS/15-185       AC A9BQJ5.1
#=GS Q09BA3_STIAD/4-172        AC Q09BA3.1
#=GS Q87US8_PSESM/8-180        AC Q87US8.1
#=GS A1BCD3_PARDP/4-168        AC A1BCD3.1
#=GS C8X7U9_NAKMY/3-173        AC C8X7U9.1
#=GS A0A0D5LRJ8_9RHIZ/8-177    AC A0A0D5LRJ8.1
#=GS A0A023X747_9ACTN/19-172   AC A0A023X747.1
#=GS A0A090M148_OSTTA/4-168    AC A0A090M148.1
#=GS RBBP9_RAT/7-183           AC O88350.2
#=GS Q13W95_BURXL/9-182        AC Q13W95.1
#=GS H8MZZ6_CORCM/5-183        AC H8MZZ6.1
#=GS D7A514_STAND/10-183       AC D7A514.1
#=GS A0A096MLK6_PAPAN/7-183    AC A0A096MLK6.1
#=GS H0PZQ3_9RHOO/5-181        AC H0PZQ3.1
#=GS W5NFC3_LEPOC/64-227       AC W5NFC3.1
#=GS K8WER4_PRORE/16-192       AC K8WER4.1
#=GS E3HGZ6_ACHXA/24-192       AC E3HGZ6.1
#=GS M1RMK1_MORMO/6-185        AC M1RMK1.1
#=GS A0A0D5VBF3_9BURK/13-177   AC A0A0D5VBF3.1
#=GS Q98JQ9_RHILO/4-172        AC Q98JQ9.1
#=GS I0GZG8_ACTM4/6-185        AC I0GZG8.1
#=GS F0YIS5_AURAN/306-432      AC F0YIS5.1
#=GS RBBP9_MOUSE/7-183         AC O88851.2
#=GS Q11IU6_CHESB/15-184       AC Q11IU6.1
#=GS A6X019_OCHA4/4-173        AC A6X019.1
#=GS A3N2M2_ACTP2/4-177        AC A3N2M2.1
#=GS A8DVW1_NEMVE/2-99         AC A8DVW1.1
#=GS K0JT56_SACES/6-187        AC K0JT56.1
#=GS A0A067CX85_SAPPC/16-190   AC A0A067CX85.1
#=GS I3TUG0_TISMK/27-154       AC I3TUG0.1
#=GS A0A0D5EMZ9_9BURK/9-184    AC A0A0D5EMZ9.1
#=GS Q98NM4_RHILO/8-177        AC Q98NM4.1
#=GS F9X5W3_ZYMTI/304-410      AC F9X5W3.1
#=GS Q47E57_DECAR/4-166        AC Q47E57.1
#=GS F0Y0G4_AURAN/14-178       AC F0Y0G4.1
#=GS I0KEI3_9BACT/26-195       AC I0KEI3.1
#=GS W5C0Y1_WHEAT/1-68         AC W5C0Y1.1
#=GS U7G743_9RHOB/8-178        AC U7G743.1
#=GS N9G7E6_ACIHA/4-179        AC N9G7E6.1
#=GS J0QZV0_9RHIZ/8-177        AC J0QZV0.1
#=GS H2IT14_RAHAC/9-171        AC H2IT14.1
#=GS C7RI43_ANAPD/28-211       AC C7RI43.1
#=GS B0UJ49_METS4/8-177        AC B0UJ49.1
#=GS Q49YM4_STAS1/4-181        AC Q49YM4.1
#=GS F7GC53_CALJA/7-166        AC F7GC53.1
#=GS D0J0G1_COMT2/7-186        AC D0J0G1.1
#=GS V3ZTH6_LOTGI/6-176        AC V3ZTH6.1
#=GS X4Z4V9_9BORD/5-173        AC X4Z4V9.1
#=GS Q30UA6_SULDN/4-176        AC Q30UA6.1
#=GS A0A089LMA1_9BACL/5-181    AC A0A089LMA1.1
#=GS U5MV27_CLOSA/6-185        AC U5MV27.1
#=GS H5WT19_9BURK/9-178        AC H5WT19.1
#=GS D5V517_ARCNC/5-176        AC D5V517.1
#=GS Q9I6T7_PSEAE/8-180        AC Q9I6T7.1
#=GS C3MCK3_RHISN/62-231       AC C3MCK3.1
#=GS A8IS06_CHLRE/2-140        AC A8IS06.1
#=GS A0A0B5DYQ1_9RHOB/4-168    AC A0A0B5DYQ1.1
#=GS Q63HX2_BURPS/8-183        AC Q63HX2.1
#=GS B6BGL4_SULGG/5-175        AC B6BGL4.1
#=GS Q11XK9_CYTH3/18-188       AC Q11XK9.1
#=GS A0A0B4XRS8_9GAMM/10-179   AC A0A0B4XRS8.1
#=GS C5ZWA1_9HELI/28-210       AC C5ZWA1.1
#=GS B0SW00_CAUSK/5-169        AC B0SW00.1
#=GS E8TFC0_MESCW/8-177        AC E8TFC0.1
#=GS X2H879_9NEIS/12-190       AC X2H879.1
#=GS H6MYF0_GORPV/17-154       AC H6MYF0.1
#=GS Q0ALN9_MARMM/8-178        AC Q0ALN9.1
#=GS D8IQQ6_HERSS/19-186       AC D8IQQ6.1
#=GS A4JDM7_BURVG/6-179        AC A4JDM7.1
#=GS C6WQ54_ACTMD/6-188        AC C6WQ54.1
#=GS A9HPJ0_GLUDA/22-197       AC A9HPJ0.1
#=GS A0A0A7KEZ9_9DEIO/5-179    AC A0A0A7KEZ9.1
#=GS R5TGD0_9CLOT/4-179        AC R5TGD0.1
#=GS C6XRE3_HIRBI/8-179        AC C6XRE3.1
#=GS A0A0C4YCJ6_9BURK/9-175    AC A0A0C4YCJ6.1
#=GS N8TLQ0_ACIGI/23-200       AC N8TLQ0.1
#=GS Q7N132_PHOLL/6-184        AC Q7N132.1
#=GS H0WLQ9_OTOGA/7-183        AC H0WLQ9.1
#=GS A9D696_9RHIZ/8-177        AC A9D696.1
#=GS I4B5I3_TURPD/6-176        AC I4B5I3.1
#=GS C1CXD2_DEIDV/5-177        AC C1CXD2.1
#=GS F6U6W8_HORSE/6-183        AC F6U6W8.1
#=GS N8Y9L1_9GAMM/4-179        AC N8Y9L1.1
#=GS A0A0D5EM20_9BURK/6-179    AC A0A0D5EM20.1
#=GS A4F9G0_SACEN/3-181        AC A4F9G0.1
#=GS B9EA50_MACCJ/22-176       AC B9EA50.1
#=GS A6Q5L1_NITSB/4-176        AC A6Q5L1.1
#=GS F2LF51_BURGS/13-177       AC F2LF51.1
#=GS E5UMS4_NEIMU/15-172       AC E5UMS4.1
#=GS M4S3C5_9SPHN/15-187       AC M4S3C5.1
#=GS B2UAU8_RALPJ/23-194       AC B2UAU8.1
#=GS G3SNA6_LOXAF/7-183        AC G3SNA6.1
#=GS Q88CL3_PSEPK/8-180        AC Q88CL3.1
#=GS H3EGL6_PRIPA/3-96         AC H3EGL6.1
#=GS F2J2E5_POLGS/1-61         AC F2J2E5.1
#=GS V5SGI7_9RHIZ/10-172       AC V5SGI7.1
#=GS A4X3T4_SALTO/17-195       AC A4X3T4.1
#=GS V5XBN7_MYCNE/1-176        AC V5XBN7.1
#=GS R4PUJ9_9BACT/4-175        AC R4PUJ9.1
#=GS S6AIE8_PSERE/9-184        AC S6AIE8.1
#=GS A0A068SSA7_RHIGA/8-177    AC A0A068SSA7.1
#=GS Q3IXK0_RHOS4/4-169        AC Q3IXK0.1
#=GS A2SBZ3_METPP/11-182       AC A2SBZ3.1
#=GS A0A024HFL3_PSEKB/8-180    AC A0A024HFL3.1
#=GS G4RE59_PELHB/8-178        AC G4RE59.1
#=GS C1DNY0_AZOVD/8-180        AC C1DNY0.1
#=GS X4Z5Q5_9BACL/5-182        AC X4Z5Q5.1
#=GS Q63Y52_BURPS/20-186       AC Q63Y52.1
#=GS S0EVK4_CHTCT/6-194        AC S0EVK4.1
#=GS A0A059MIF0_9NOCA/9-184    AC A0A059MIF0.1
#=GS A0A0C5LBR5_9SPHN/27-192   AC A0A0C5LBR5.1
#=GS Q8XZQ1_RALSO/23-192       AC Q8XZQ1.1
#=GS F4F9N9_VERMA/4-176        AC F4F9N9.1
#=GS Q9JXE8_NEIMB/15-172       AC Q9JXE8.1
#=GS B4E9E0_BURCJ/9-184        AC B4E9E0.1
#=GS Q0K9I4_CUPNH/23-189       AC Q0K9I4.1
#=GS A2DXW0_TRIVA/6-184        AC A2DXW0.1
#=GS Q484D8_COLP3/4-172        AC Q484D8.1
#=GS G2IVI7_PSEUL/9-194        AC G2IVI7.1
#=GS Q0JY63_CUPNH/8-187        AC Q0JY63.1
#=GS B8IPK0_METNO/8-177        AC B8IPK0.1
#=GS Q7VYN0_BORPE/5-173        AC Q7VYN0.1
#=GS I0HK69_RUBGI/7-176        AC I0HK69.1
#=GS D5W9R7_BURSC/8-181        AC D5W9R7.1
#=GS B9DMZ7_STACT/4-180        AC B9DMZ7.1
#=GS Q6F9B1_ACIAD/4-179        AC Q6F9B1.1
#=GS A0A0B5DVT6_9RHOB/5-174    AC A0A0B5DVT6.1
#=GS G1LF54_AILME/10-186       AC G1LF54.1
#=GS A0A022LMT1_9MICO/7-195    AC A0A022LMT1.1
#=GS K0HVG7_9BURK/6-175        AC K0HVG7.1
#=GS H3ALB1_LATCH/26-202       AC H3ALB1.1
#=GS C3YA81_BRAFL/8-177        AC C3YA81.1
#=GS Q2JAI4_FRASC/13-182       AC Q2JAI4.1
#=GS B2GFC0_LACF3/4-149        AC B2GFC0.1
#=GS A9FXP3_SORC5/4-172        AC A9FXP3.1
#=GS A0A023NPQ9_9GAMM/10-185   AC A0A023NPQ9.1
#=GS R1E212_EMIHU/3-174        AC R1E212.1
#=GS A0KNA5_AERHH/6-183        AC A0KNA5.1
#=GS A0A0B5HZ96_9ARCH/4-182    AC A0A0B5HZ96.1
#=GS V2UM34_9GAMM/4-179        AC V2UM34.1
#=GS Q9A6A9_CAUCR/12-181       AC Q9A6A9.1
#=GS B0VLX7_ACIBS/33-210       AC B0VLX7.1
#=GS G2IZ81_PSEUL/10-177       AC G2IZ81.1
#=GS L0GWS3_9GAMM/5-185        AC L0GWS3.1
#=GS Q12AZ6_POLSJ/3-168        AC Q12AZ6.1
#=GS C3K295_PSEFS/16-194       AC C3K295.1
#=GS B1Y6Z4_LEPCP/26-195       AC B1Y6Z4.1
#=GS A0A0A1DRE2_NOCSI/10-184   AC A0A0A1DRE2.1
#=GS A0A0B5HRF9_9ARCH/4-188    AC A0A0B5HRF9.1
#=GS Q5ZZE3_LEGPH/14-194       AC Q5ZZE3.1
#=GS Q82DP8_STRAW/12-189       AC Q82DP8.1
#=GS Q2K160_RHIEC/4-173        AC Q2K160.1
#=GS G8ANW2_AZOBR/6-178        AC G8ANW2.1
#=GS I0HRM5_RUBGI/28-190       AC I0HRM5.1
#=GS Q1LCH4_RALME/9-188        AC Q1LCH4.1
#=GS K4R0W9_9ACTN/4-177        AC K4R0W9.1
#=GS A9C3A9_DELAS/6-171        AC A9C3A9.1
#=GS G8QIT1_AZOSU/7-175        AC G8QIT1.1
#=GS A0A0D5V5D1_9BURK/8-181    AC A0A0D5V5D1.1
#=GS C6RS06_ACIRA/6-182        AC C6RS06.1
#=GS A0A0C5LGV7_9SPHN/14-186   AC A0A0C5LGV7.1
#=GS A4Y0H4_PSEMY/8-180        AC A4Y0H4.1
#=GS D1B195_SULD5/16-184       AC D1B195.1
#=GS A0A0C1DKV8_9FLAO/5-175    AC A0A0C1DKV8.1
#=GS C2GDZ4_9CORY/15-194       AC C2GDZ4.1
#=GS I3TI47_TISMK/6-177        AC I3TI47.1
#=GS E4T7J6_PALPW/4-173        AC E4T7J6.1
#=GS B9JVT8_AGRVS/8-177        AC B9JVT8.1
#=GS B9JGF9_AGRRK/4-173        AC B9JGF9.1
#=GS D3EI54_GEOS4/19-165       AC D3EI54.1
#=GS E8UBV1_DEIML/10-182       AC E8UBV1.1
#=GS Q5FT58_GLUOX/41-211       AC Q5FT58.1
#=GS H2JKJ2_STRHJ/6-183        AC H2JKJ2.1
#=GS B2UJZ3_RALPJ/7-176        AC B2UJZ3.1
#=GS F4FHH1_VERMA/5-177        AC F4FHH1.1
#=GS Q92PJ1_RHIME/8-177        AC Q92PJ1.1
#=GS X5A073_9BACL/1-130        AC X5A073.1
#=GS D9SR21_CLOC7/3-171        AC D9SR21.1
#=GS C5CNV5_VARPS/5-170        AC C5CNV5.1
#=GS F2REG2_STRVP/8-181        AC F2REG2.1
#=GS A9IM25_BORPD/24-192       AC A9IM25.1
#=GS E4TW93_SULKY/4-176        AC E4TW93.1
#=GS G5CBB2_HETGA/7-184        AC G5CBB2.1
#=GS K8WLT4_9ENTR/16-195       AC K8WLT4.1
#=GS B4E6Y0_BURCJ/6-179        AC B4E6Y0.1
#=GS A1VMH8_POLNA/3-168        AC A1VMH8.1
#=GS Q8XX01_RALSO/5-175        AC Q8XX01.1
#=GS Q1IXA1_DEIGD/5-174        AC Q1IXA1.1
#=GS Q4KK59_PSEF5/8-180        AC Q4KK59.1
#=GS B2IJD9_BEII9/8-178        AC B2IJD9.1
#=GS E6WZ51_NITSE/3-176        AC E6WZ51.1
#=GS A0A068T2J2_RHIGA/4-173    AC A0A068T2J2.1
#=GS D0J7P7_COMT2/11-181       AC D0J7P7.1
#=GS A0A077LFI0_9PSED/8-180    AC A0A077LFI0.1
#=GS K0CL93_ALCDB/11-170       AC K0CL93.1
#=GS Q2YNJ2_BRUA2/8-177        AC Q2YNJ2.1
#=GS K0W974_PSEFL/8-180        AC K0W974.1
#=GS B3PI39_CELJU/23-185       AC B3PI39.1
#=GS W0EVT2_9SPHI/23-174       AC W0EVT2.1
#=GS Q7P136_CHRVO/10-177       AC Q7P136.1
#=GS Q5F5D3_NEIG1/15-172       AC Q5F5D3.1
#=GS A0A0D4DCZ7_9ACTN/4-189    AC A0A0D4DCZ7.1
#=GS B5HND3_9ACTN/24-202       AC B5HND3.1
#=GS Q6D2K4_PECAS/19-181       AC Q6D2K4.1
#=GS Q6D2K4_PECAS/19-181       DR PDB; 3BDV B; 19-181;
#=GS Q6D2K4_PECAS/19-181       DR PDB; 3BDV A; 19-181;
#=GS F5Y2G4_RAMTT/6-175        AC F5Y2G4.1
#=GS D5UZM7_ARCNC/8-186        AC D5UZM7.1
#=GS D5QIR4_KOMHA/47-218       AC D5QIR4.1
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