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Database: Pfam
Entry: Sial-lect-inser
LinkDB: Sial-lect-inser
Original site: Sial-lect-inser 
#=GF ID   Sial-lect-inser
#=GF AC   PF09264.9
#=GF DE   Vibrio cholerae sialidase, lectin insertion
#=GF AU   Sammut SJ
#=GF SE   pdb_1w0p
#=GF GA   25.00 25.00;
#=GF TC   28.70 25.60;
#=GF NC   21.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15226294
#=GF RT   Sialic acid recognition by Vibrio cholerae neuraminidase. 
#=GF RA   Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel
#=GF RA   MJ, von Itzstein M, Taylor G; 
#=GF RL   J Biol Chem. 2004;279:40819-40826.
#=GF DR   INTERPRO; IPR015344;
#=GF DR   SCOP; 1w0p; fa;
#=GF CC   Members of this family are predominantly found in Vibrio
#=GF CC   cholerae sialidase, and adopt a beta sandwich structure
#=GF CC   consisting of 12-14 strands arranged in two beta-sheets. They
#=GF CC   bind to lectins with high affinity helping to target the protein
#=GF CC   to sialic acid-rich environments, thereby enhancing the
#=GF CC   catalytic efficiency of the enzyme [1].
#=GF SQ   11
#=GS A8H2Q3_SHEPA/436-594      AC A8H2Q3.1
#=GS D0Z2P3_PHODD/67-233       AC D0Z2P3.1
#=GS A8H2Q3_SHEPA/57-229       AC A8H2Q3.1
#=GS A6CVX2_9VIBR/347-544      AC A6CVX2.1
#=GS NANH_VIBCH/347-543        AC P0C6E9.1
#=GS NANH_VIBCH/347-543        DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/347-543        DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/347-543        DR PDB; 1W0P A; 347-543;
#=GS A0A135I7Y9_9GAMM/345-542  AC A0A135I7Y9.1
#=GS A0A0M0II64_9VIBR/149-348  AC A0A0M0II64.1
#=GS A6CVX2_9VIBR/65-230       AC A6CVX2.1
#=GS A0A081KGM9_9GAMM/380-578  AC A0A081KGM9.1
#=GS D0Z2P3_PHODD/345-542      AC D0Z2P3.1
#=GS NANH_VIBCH/65-221         AC P0C6E9.1
#=GS NANH_VIBCH/65-221         DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/65-221         DR PDB; 2W68 B; 65-216;
#=GS NANH_VIBCH/65-221         DR PDB; 2W68 C; 65-215;
#=GS NANH_VIBCH/65-221         DR PDB; 2W68 A; 65-216;
#=GS NANH_VIBCH/65-221         DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/65-221         DR PDB; 1W0P A; 347-543;
A8H2Q3_SHEPA/436-594                 .......qaawqargingraeweiqpsvqvnrdattl--------------------------.------...GWKMTTTSRIVSGSAISDYYAN....GNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGA--DKYHTYEVTYD.VETSLATFYFDGIAI.E.TW.AG.SATSQNVIVWGNGSSGTNGV----------------------------.-.-----.---------------------anyryvnfetfgsgpaifesi..
D0Z2P3_PHODD/67-233                  ......................vngndgranwtitpt-------------------------T.ELNNQAtryGWTLSTEMRVVSGGYITNYYAN....GQHRFLPIISLQ-NGNLVAEFEGRSGATILASGD-DVHGYHKYDIVFHpGPNPTASFFFDGVLI.KsDW.QG.HPSSQNMIAWGNGSSSQAGEAYYRSITFTISGD---------------.-.-----.---------------------pvfstpdripslvtssqtp....
A8H2Q3_SHEPA/57-229                  ...svaqdlnaaswkstgssgraqwnmvpttelnnea--------------------------.---SLK...GWRMSWTSRVESGGYITDYYAN....GALRFLPILSISASGDLVVNLVGGGEHTLVSGTGA--DSYHQYVVEYD.PLTQLASFSFDGVII.DpAW.VG.EASNQNMIAWGNGSSNINGVAYYR------------------------.-.-----.---------------------avtfetlsetvpeeakiiaawds
A6CVX2_9VIBR/347-544                 .....................................DVTHQVKEHSYQIAGWGGSELYSKSA.TLNSNQ...DWQLNATLRIFDGAANRIQAAD....GARTFVVTFAVDPSGQLTAQLNGESSPVVVALSSGDVYGFHQYQIAYS.ALSNQASLLVDGNTL.A.SW.SG.ETSSSNLVEFGNADSSVDGRIHLQDIALEQSGVTLVSLDAAYLAQQDP.AsTTTDL.EQLGWSKQKSGNTMSFYGHAS.......................
NANH_VIBCH/347-543                   .....................................DVTDQVKERSFQIAGWGGSELYRRNT.SLNSQQ...DWQSNAKIRIVDGAANQIQVAD....GSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYS.ALNHTTTLFVDGQQI.T.TW.AG.EVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTP.E.VEKDL.EKLGWTKIKTGNTMSLYGNAS.......................
#=GR NANH_VIBCH/347-543        SS    .....................................E-HHHHS---EEEEESSEEEEEEEE-.---TTS...-EEEEEEEEEEEES-EEEEEEE....SSEEEEEEEEE-TTS-EEEEETT--S-EEEE-SHHHHTS-EEEEEEEE.TTTTEEEEEETTEEE.E.EE.--.EE-S-EEEEEEE--TTS-EEEEEEEEEEEETTEEEEEEEHHHHHTS-T.T.S---T.GGTT-EEEEEES-EEEES-SE.......................
A0A135I7Y9_9GAMM/345-542             .....................................NVTEDIKERTFQIIGWGGSEYYTKSV.ELSSQD...EWELTTKLRIQGGGANDLSVSN....GDKRFTLSLAMGNESSLVAYVDESTTPITIREKTENITGFVDVSLRFD.PEEGSANLYIDDDFI.T.EV.AG.IPSTDTQVLFGQTANDIEGRMHIANLALSRQGDAVIEFDAEALSLINP.S.EQNVLpDALGWTKNHSGRAYSFYGVAS.......................
A0A0M0II64_9VIBR/149-348             dvldqvkdvnwmanginsidgratwsatpsqaqidqa--------------------------.---NSE...GWSLSWNSRVADGSCNVQYYGN....GSKRFLADLQVNADKSVKAVLYSDSANLEFPMDF-DISAYHDYKIV--.GHGSTASFYVDGTLVaT.NW.SG.QSHSSKTVTWGNGCSSTKGASAYHTIDFSIADNQQFYFDASLMERVNG.T.IIKHP.AEQGWTKTSARN---------grgdpg.................
A6CVX2_9VIBR/65-230                  ..............awvaqgeggraqwktvlsdalks--------------------------.-QATNY...GWRLSTEMRVVSGGMITNYYAD....GSQRVLPILSINSAGELVVEFEGRSGTTVLATGAA-ATDYHKYELVFHpGDNPNASFYFDGQLI.L.DQ.ISpSPTSQNMLVWGNGSTYTDGVSAYKNIEFEVQGD---------------.-.-----.---------------------vifngpdripslva.........
A0A081KGM9_9GAMM/380-578             .....................................DITAQVRERAWDARGWSGKAAWSFDI.TDALQT...PAAGNWS-LVTDRKAIQGQITDylvtGEAILLPTVTVTEANNLVVNLNGTGGGDFTLLEDVGPAEFHTSEIRYD.PVTKTASYLFDGEVI.AsNW.SG.APNSAKKVVFGNDLTNDEGRATYKSANFTIGETTVIDYS----ASATP.A.AEATP.VAQGWT---------------aelaekgrgilgwkstn......
D0Z2P3_PHODD/345-542                 ....................................n-VSSHVKEKTLQIVGWSGSEFYSKSLdEISSQN...SWSLQSKLKIYNGKDNDLVVAN....GTKQYKISFAVNEN-GLVAYLDDQNSAKLIRTTIQNIAGFINVAMDFD.PVTQTAQLTIDDAVV.G.TL.SG.IPSADKHILFGQTNAAHDGRLHIANINLNVNGQRVIDYDAETLTDINPnE.MNNTP.ESQGWSKHKSGRAYSFYGVAS.......................
NANH_VIBCH/65-221                    .................awlvqgiggraqwtyslstn------------------------QH.AQASSF...GWRMTTEMKVLSGGMITNYYAN....GTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAA-TEYHKFELVFLpGSNPSASFYFDGKLI.R.DNiQP.TASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGD---------------.-.-----.---------------------vifrg..................
#=GR NANH_VIBCH/65-221         SS    .................EEEEEESSS-EEEEE---HH------------------------HH.HHHHHH...-EEEEEEEEEEEES-EE-EEEE....SSEEE-EEEEE-TTS-EEEEETTS-S-EEEE-GGGG-GSEEEEEEEEE-SSS-EEEEEETTEEE.E.EEE--.EEEEEEEEEEEE--SSS-EEEEEEEEEEEES-E---------------.-.-----.---------------------EEE-T..................
#=GC SS_cons                         .................EEEEEESSS-EEEEE---HHE-HHHHS---EEEEESSEEEEEEECH.HHHCCC...-EEEEEEEEEEEES-EEEEEEE....SSEEEEEEEEE-TTS-EEEEETTS-S-EEEE-CHHHHCSEEEEEEEEE-TTTTEEEEEETTEEE.E.EEE--.EEECEEEEEEEE--TTS-EEEEEEEEEEEETTEEEEEEEHHHHHTS-T.T.S---T.GGTT-EEEEEES-EEEES-SEEEE-T..................
#=GC seq_cons                        ..............................................................h.t.sopp...uWphosphRlhsGus.sthhAN....Gs+RaLshlolsssGsLVApLpGpoussllstsssshsuaHpYclsac.s.ssoASaahDGplI.s.sW.uG.psSopNhlsaGNusosp-GththpsIshphpGs.............................................s.h....................
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