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Database: Pfam
Entry: Sial-lect-inser
LinkDB: Sial-lect-inser
Original site: Sial-lect-inser 
#=GF ID   Sial-lect-inser
#=GF AC   PF09264.8
#=GF DE   Vibrio cholerae sialidase, lectin insertion
#=GF AU   Sammut SJ
#=GF SE   pdb_1w0p
#=GF GA   25.00 25.00;
#=GF TC   81.60 25.60;
#=GF NC   21.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15226294
#=GF RT   Sialic acid recognition by Vibrio cholerae neuraminidase. 
#=GF RA   Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel
#=GF RA   MJ, von Itzstein M, Taylor G; 
#=GF RL   J Biol Chem. 2004;279:40819-40826.
#=GF DR   INTERPRO; IPR015344;
#=GF DR   SCOP; 1w0p; fa;
#=GF CC   Members of this family are predominantly found in Vibrio
#=GF CC   cholerae sialidase, and adopt a beta sandwich structure
#=GF CC   consisting of 12-14 strands arranged in two beta-sheets. They
#=GF CC   bind to lectins with high affinity helping to target the protein
#=GF CC   to sialic acid-rich environments, thereby enhancing the
#=GF CC   catalytic efficiency of the enzyme [1].
#=GF SQ   8
#=GS A8H2Q3_SHEPA/436-594  AC A8H2Q3.1
#=GS D0Z2P3_PHODD/67-233   AC D0Z2P3.1
#=GS A6CVX2_9VIBR/65-230   AC A6CVX2.1
#=GS D0Z2P3_PHODD/345-542  AC D0Z2P3.1
#=GS A8H2Q3_SHEPA/57-229   AC A8H2Q3.1
#=GS A6CVX2_9VIBR/347-544  AC A6CVX2.1
#=GS NANH_VIBCH/65-221     AC P0C6E9.1
#=GS NANH_VIBCH/65-221     DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 B; 65-216;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 C; 65-215;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 A; 65-216;
#=GS NANH_VIBCH/65-221     DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 1W0P A; 347-543;
#=GS NANH_VIBCH/347-543    AC P0C6E9.1
#=GS NANH_VIBCH/347-543    DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/347-543    DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/347-543    DR PDB; 1W0P A; 347-543;
A8H2Q3_SHEPA/436-594             ....qaawqargingraeweiqpsvqvnrdattl--------------------------.------...GWKMTTTSRIVSGSAISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGA--DKYHTYEVTYD.VETSLATFYFDGIAIE.TW.AG.SATSQNVIVWGNGSSGTNGV----------------------------.-.--------------------------anyryvnfetfgsgpaifesi..
D0Z2P3_PHODD/67-233              ...................vngndgranwtitpt-------------------------T.ELNNQAtryGWTLSTEMRVVSGGYITNYYANGQHRFLPIISLQ-NGNLVAEFEGRSGATILASGD-DVHGYHKYDIVFHpGPNPTASFFFDGVLIKsDW.QG.HPSSQNMIAWGNGSSSQAGEAYYRSITFTISGD---------------.-.--------------------------pvfstpdripslvtssqtp....
A6CVX2_9VIBR/65-230              ...........awvaqgeggraqwktvlsdalks--------------------------.-QATNY...GWRLSTEMRVVSGGMITNYYADGSQRVLPILSINSAGELVVEFEGRSGTTVLATGAA-ATDYHKYELVFHpGDNPNASFYFDGQLIL.DQ.ISpSPTSQNMLVWGNGSTYTDGVSAYKNIEFEVQGD---------------.-.--------------------------vifngpdripslva.........
D0Z2P3_PHODD/345-542             .................................n-VSSHVKEKTLQIVGWSGSEFYSKSLdEISSQN...SWSLQSKLKIYNGKDNDLVVANGTKQYKISFAVNEN-GLVAYLDDQNSAKLIRTTIQNIAGFINVAMDFD.PVTQTAQLTIDDAVVG.TL.SG.IPSADKHILFGQTNAAHDGRLHIANINLNVNGQRVIDYDAETLTDINPnE.MNNTPESQGWSKHKSGRAYSFYGVAS.......................
A8H2Q3_SHEPA/57-229              svaqdlnaaswkstgssgraqwnmvpttelnnea--------------------------.---SLK...GWRMSWTSRVESGGYITDYYANGALRFLPILSISASGDLVVNLVGGGEHTLVSGTGA--DSYHQYVVEYD.PLTQLASFSFDGVIIDpAW.VG.EASNQNMIAWGNGSSNINGVAYYR------------------------.-.--------------------------avtfetlsetvpeeakiiaawds
A6CVX2_9VIBR/347-544             ..................................DVTHQVKEHSYQIAGWGGSELYSKSA.TLNSNQ...DWQLNATLRIFDGAANRIQAADGARTFVVTFAVDPSGQLTAQLNGESSPVVVALSSGDVYGFHQYQIAYS.ALSNQASLLVDGNTLA.SW.SG.ETSSSNLVEFGNADSSVDGRIHLQDIALEQSGVTLVSLDAAYLAQQDP.AsTTTDLEQLGWSKQKSGNTMSFYGHAS.......................
NANH_VIBCH/65-221                ..............awlvqgiggraqwtyslstn------------------------QH.AQASSF...GWRMTTEMKVLSGGMITNYYANGTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAA-TEYHKFELVFLpGSNPSASFYFDGKLIR.DNiQP.TASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGD---------------.-.--------------------------vifrg..................
#=GR NANH_VIBCH/65-221     SS    ..............EEEEEESSS-EEEEE---HH------------------------HH.HHHHHH...-EEEEEEEEEEEES-EE-EEEESSEEE-EEEEE-TTS-EEEEETTS-S-EEEE-GGGG-GSEEEEEEEEE-SSS-EEEEEETTEEEE.EEE--.EEEEEEEEEEEE--SSS-EEEEEEEEEEEES-E---------------.-.--------------------------EEE-T..................
NANH_VIBCH/347-543               ..................................DVTDQVKERSFQIAGWGGSELYRRNT.SLNSQQ...DWQSNAKIRIVDGAANQIQVADGSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYS.ALNHTTTLFVDGQQIT.TW.AG.EVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTP.E.VEKDLEKLGWTKIKTGNTMSLYGNAS.......................
#=GR NANH_VIBCH/347-543    SS    ..................................E-HHHHS---EEEEESSEEEEEEEE-.---TTS...-EEEEEEEEEEEES-EEEEEEESSEEEEEEEEE-TTS-EEEEETT--S-EEEE-SHHHHTS-EEEEEEEE.TTTTEEEEEETTEEEE.EE.--.EE-S-EEEEEEE--TTS-EEEEEEEEEEEETTEEEEEEEHHHHHTS-T.T.S---TGGTT-EEEEEES-EEEES-SE.......................
#=GC SS_cons                     ..............EEEEEESSS.EEEEE...HHE-HHHHS---EEEEESSEEEEEEECH.HHHCCC...-EEEEEEEEEEEES-EEEEEEESSEEEEEEEEE-TTS-EEEEETTS-S-EEEE-CHHHHCSEEEEEEEEE.TTTTEEEEEETTEEEE.EEE--.EEECEEEEEEEE--TTS-EEEEEEEEEEEETTEEEEEEEHHHHHTS-T.T.S---TGGTT-EEEEEES-EEEES-SEEEE.T..................
#=GC seq_cons                    ........................h.h......s.........................h.t.sSpt...GWphoochRllSGuhIosYYANGs+RaLsllSlssuGsLVApL-GpSusTlluossAthsuYHpY-lsac.u.sssASFaFDGtlIp.sW.sG.psSuQNhIsWGNGSSspDGhhahpsIthp.pGp............................................s.h....................
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