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Database: Pfam
Entry: Sial-lect-inser
LinkDB: Sial-lect-inser
Original site: Sial-lect-inser 
#=GF ID   Sial-lect-inser
#=GF AC   PF09264.7
#=GF DE   Vibrio cholerae sialidase, lectin insertion
#=GF AU   Sammut SJ
#=GF SE   pdb_1w0p
#=GF GA   25.00 25.00;
#=GF TC   81.60 25.60;
#=GF NC   21.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15226294
#=GF RT   Sialic acid recognition by Vibrio cholerae neuraminidase. 
#=GF RA   Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel
#=GF RA   MJ, von Itzstein M, Taylor G; 
#=GF RL   J Biol Chem. 2004;279:40819-40826.
#=GF DR   INTERPRO; IPR015344;
#=GF DR   SCOP; 1w0p; fa;
#=GF CC   Members of this family are predominantly found in Vibrio
#=GF CC   cholerae sialidase, and adopt a beta sandwich structure
#=GF CC   consisting of 12-14 strands arranged in two beta-sheets. They
#=GF CC   bind to lectins with high affinity helping to target the protein
#=GF CC   to sialic acid-rich environments, thereby enhancing the
#=GF CC   catalytic efficiency of the enzyme [1].
#=GF SQ   4
#=GS A8H2Q3_SHEPA/436-594  AC A8H2Q3.1
#=GS A8H2Q3_SHEPA/57-229   AC A8H2Q3.1
#=GS NANH_VIBCH/65-221     AC P0C6E9.1
#=GS NANH_VIBCH/65-221     DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 B; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 C; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 2W68 A; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/65-221     DR PDB; 1W0P A; 347-543;
#=GS NANH_VIBCH/347-543    AC P0C6E9.1
#=GS NANH_VIBCH/347-543    DR PDB; 1KIT A; 347-543;
#=GS NANH_VIBCH/347-543    DR PDB; 1W0O A; 347-543;
#=GS NANH_VIBCH/347-543    DR PDB; 1W0P A; 347-543;
A8H2Q3_SHEPA/436-594             ....qaawqargingraeweiqpsvqvnrdattl--------------------------------GWKMTTTSRIVSGSAISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGA--DKYHTYEVTYD.VETSLATFYFDGIAIE.TW.AGSATSQNVIVWGNGSSGTNGV-------------------------------------------------------anyryvnfetfgsgpaifesi..
A8H2Q3_SHEPA/57-229              svaqdlnaaswkstgssgraqwnmvpttelnnea-----------------------------SLKGWRMSWTSRVESGGYITDYYANGALRFLPILSISASGDLVVNLVGGGEHTLVSGTGA--DSYHQYVVEYD.PLTQLASFSFDGVIIDpAW.VGEASNQNMIAWGNGSSNINGVAYYR---------------------------------------------------avtfetlsetvpeeakiiaawds
NANH_VIBCH/65-221                ..............awlvqgiggraqwtyslstn------------------------QHAQASSFGWRMTTEMKVLSGGMITNYYANGTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAA-TEYHKFELVFLpGSNPSASFYFDGKLIR.DNiQPTASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGD------------------------------------------vifrg..................
#=GR NANH_VIBCH/65-221     SS    ..............E---HHHHHHHHHH-EEEEE------------------------EEE-TTS-EEEEETTS-S-EEEE-GGGGGSEEEEEEEEE-SSS-EEEEEETTEEEEEEE--EEEEE-EEEEEE--SSS-EEEEEEEEEEEES-EE.E-TXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------------------------------XXXXX..................
NANH_VIBCH/347-543               ..................................DVTDQVKERSFQIAGWGGSELYRRNTSLNSQQDWQSNAKIRIVDGAANQIQVADGSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYS.ALNHTTTLFVDGQQIT.TW.AGEVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTPEVEKDLEKLGWTKIKTGNTMSLYGNAS.......................
#=GR NANH_VIBCH/347-543    SS    ..................................EEEEEEEEEEES-EEEEEEESSEEEEEEEEE-TTS-EEEEETT--S-EEEE-SHHHHTS-EEEEEEEETTTTEEEEEETTEEEEEE--EE-S-EEEEEEE--.TS-EEEEEEEEEEEET.EE.EEEEHHHHHTS-TTS---TGGTT-EEEEEES-EEEES-SEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......................
#=GC SS_cons                     ..............E...HHHHHHHHHH.EEEEEEEEEEEEEEEES-EEEEEEESSEEEEEECCC-CCCEECCCETTEECEECCCGCCCCCCCEEEEECCCECCCCEECCEECCEEEEEEEEEE-CEEEEEEECSS.CCEEEEEEEEEECEEC.EETEEEEHHHHHTS-TTS---TGGTT-EEEEEES-EEEES-SEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......................
#=GC seq_cons                    ..............u....t..s.s.hs...sp..............................S..GW+Mosp.RllSGuhIosYYANGspRaLslLSIsuSGsLVssLpGsou+TllssssA..cpYHpYElpYs.s.sphAoFaFDGhhIc.sW.sGpASpQNhIsWGNGSSshsGVhhhp...................................................s.hh...................
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