GenomeNet

Database: Pfam
Entry: Sialidase
LinkDB: Sialidase
Original site: Sialidase 
#=GF ID   Sialidase
#=GF AC   PF02973.13
#=GF DE   Sialidase, N-terminal domain
#=GF PI   sialidase_N; 
#=GF AU   Griffiths-Jones SR
#=GF SE   Structural domain
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.60;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Glycoside_hydrolase_family_33
#=GF RN   [1]
#=GF RM   9562562
#=GF RT   The crystal structure of an intramolecular trans-sialidase with
#=GF RT   a NeuAc alpha2-->3Gal specificity. 
#=GF RA   Luo Y, Li SC, Chou MY, Li YT, Luo M; 
#=GF RL   Structure 1998;6:521-530.
#=GF DR   INTERPRO; IPR004124;
#=GF DR   SCOP; 1sli; fa;
#=GF SQ   14
#=GS A0A075JSD0_9BACI/33-216  AC A0A075JSD0.1
#=GS Q8XMG4_CLOPE/48-236      AC Q8XMG4.1
#=GS NANA_STRR6/118-309       AC P62576.1
#=GS E8K2T7_9STRE/166-357     AC E8K2T7.1
#=GS Q8CWP8_STRR6/42-228      AC Q8CWP8.1
#=GS V4R195_STRIN/131-320     AC V4R195.1
#=GS S1R721_9ENTE/43-229      AC S1R721.1
#=GS C0MCG2_STRS7/745-914     AC C0MCG2.1
#=GS R5QCN3_9FIRM/50-229      AC R5QCN3.1
#=GS R5QDP0_9FIRM/1004-1194   AC R5QDP0.1
#=GS T1ZC06_STRIT/80-271      AC T1ZC06.1
#=GS R6V8Y4_9FIRM/45-239      AC R6V8Y4.1
#=GS Q8XMY5_CLOPE/175-367     AC Q8XMY5.1
#=GS F5WRH5_ERYRF/25-209      AC F5WRH5.1
A0A075JSD0_9BACI/33-216             ......................................epivsvene----------QIENGYFTNLNSEIDKLKK......LEEGTIVVRFRY-TG......S...SIMSLFSLSNSNLAN..GHFHLYI..S..PS..SIGSENRFQKPGEpQENVHTSAAANLKEGHV-----YTLAMVVD..-KEAGYKYFLDG.eLIKEDTTS..PRKF....LNN.IH.KPN.SA.QLGRTERAA.gGN...NYPF.KGDIDFAKIYNQPLSDETLTAITGV--ts.........................................................................
Q8XMG4_CLOPE/48-236                 .............................................ls--SLGEYKDINLESSNASNITYDLEKYKN......LDEGTIVVRFNS-KD......S...KIQSLLGISNSKTKN..GYFNFYV..T..NS..RVGFELRNQKNEG.NTQSGTENLVHMYKDVALNDGDNTVALKIE..-KNKGYKLFLNG.kIIKEVKDT..NTKF....LNN.IE.NLD.SA.FIGKTNRYG.qSN...EYNF.KGNIGFMNIYNEPLGDDYLLSKTGETK...........................................................................
NANA_STRR6/118-309                  ...............................................VETVIEKE--DVETNASNGQRVDLSSELDkl..kkLENATVHMEFKPDAK......A..pAFYNLFSVSSATKKD..EYFTMAV..Y..NN..TATLEGRGSDGKQ.FYNNYNDAPLKVKPGQWNSVTFTVEKPTAE..LPKGRVRLYVNG..VLSRTSLR..SGNF....IKD.MP.DVT.HV.QIGATKRAN..NT...VWGS.NLQIRNLTVYNRALTPEEVQKRSQLFK...........................................................................
E8K2T7_9STRE/166-357                ..............................................v-NTVVEKN--DVTTNAENNQRDDLTSDLEkl..kkLQDATVHMEFKPDAS......A..pRFYNLFSVSSDTKEN..EYFTMSV..S..DN..TALIEGRDANGAQ.FYDKYTDAPLKVRPGQWNSVTFTVEKPTTE..VPTGRVRLYVNG..VLSRTSLK..SGKF....IKD.MP.DVN.HV.QIGATKRGS..KT...VWGS.NLQVRNLTVYDRALTQDEVRTRSQLF-e..........................................................................
Q8CWP8_STRR6/42-228                 ...............................................IFQGGSYQLNNKSIDISPLLLDKLSGDSQ......----TVVMKFKADKP......N...SLQALFGLSNSKAGFknNYFSIFM..R..DS.gEIGVEIRDAQKGI.NYLFSRP--ASLWGKHKGQAVENTLVFVSD..SKDKTYTMYVNG..-IEVFSET..VDTFl..pISN.IN.GID.KA.TLGAVNREG..KE...HYLA.KGSIDEISLFNKAISDQEVSTIPLSN-p..........................................................................
V4R195_STRIN/131-320                ..............................aykenevfkidnqvlqk------------------NSKIDLSEHLDal..kkLDSATIYAEIKTPED......M..dDFMTWFSVSTSANEN..ERFYLYI..T..KE.gVVGVEGADNANKP.FYKSFTSASQRVKPSEWN-----ALAFVIN..QEAQKVQIYVNG..ILSQEDST..STQF....IKD.LA.NPE.FA.QIGQTQRGR..SN...KWGFsHFDIKNFTVYNRALSETEVGDRSQLF-i..........................................................................
S1R721_9ENTE/43-229                 ..............................................y--QSGPYILNNTGIDISDQVLNKIQGDNQ......----SIVLNFESSSP......N...SLQAIFGISNSNSGYrnNYFDIFM..R..NS.gEIGVEIRDAQKGV.NYLFARP--ASLWGIHKGNAVENTVVFTAN..ATEKTYEMYVDG..-KCIFSKK..VEVFi..pING.IT.GQN.NA.MIGAVNREG..SQ...AFTM.NGKVNQLQIFNRVLTSSEISEH-----fsrenk.....................................................................
C0MCG2_STRS7/745-914                ..................................dataekaavtdde-------------------ALSKLDDVMS......LNQGTVTIRYRLDTAdttvrsS...SPLALLSISNQASAN..EYASFFIepK..NN..KIGLEFKGAEVPI.VKVGSGFNLL--------------------..------------..--------..----....---.--.---.--.---------..--...----.---------------------------tnsdwqtisyvftgsrlkiylngdlygeadfagfmkqlpwkasadtltigglkrtydgesvlhwglkglvdqvli
R5QCN3_9FIRM/50-229                 ..............................seeqqiqgidqrfeipq---------------------EDVSFVND......LGSGTITLSFKT-GS......T...NLQALAAINGDKHAN..HYMSLYI..S..GG.nKIGFEFRKNATVN.DHRNFTVDNVNLADDQWH-----TITLAVE..-KDSYYKVYLDQ.kLVQKWEVD..ETNF....VDK.MEwEPT.SV.TFGGAKRIS..GN...SYPF.TGSIKQVKLYNEAASEDQILA------dhgav......................................................................
R5QDP0_9FIRM/1004-1194              ..........................frkedqkiavgspvelstkdy-----------------------AEKLMK......LEEGTILVHYTSTSD......Q...AIQSLFSVSNAKAGHenRHFHVYI..R..PE.gVLGCEIRNES-AM.NYGFKAA--NAVKADYKGKPAENIIALQAD..KEKGTYQLFANGekVLTVDAAAlgGYRF....ISE.IT.GLD.TV.SLGATKRGG..IN...KYTF.GGNIHKIEVYETPLTDEELIEETKK--ta.........................................................................
T1ZC06_STRIT/80-271                 ..............................................v-QTIFEKE--NVVTNDSNNQRIDLSGELDkl..kqLQTATIHIEFKADAN......A..pRFYNLFSVSSDKVKN..EYFTMAV..Y..NN..TAIVEGRDKDGKQ.FYNSYNDAPLKIKSGQWNSVTFTVDGPNSD..HPNGQVRLYVNG..VLSRTSKL..SGRF....IKD.MP.DVN.HV.QIGKTNRAR..SM...MWGS.NLHVRNLTVYNRALTSEEVQKRSQLFK...........................................................................
R6V8Y4_9FIRM/45-239                 ......................................iqnglvfeq-----------NNIDIVQGQGYDVSSEEGaeyveaLSEGTIIISFKSTSQ......N...QYQSLISIGNNRTGNqnRHFHLYI..T..NT.gAVGMELRNTDSVF.KYTLSRP--AALRSKYKNEYVSNTVAFKAD..RENHQYKLFANG.eLLATLDKE..DFKF....ISD.IT.EVN.NV.MLGGTNRQG..TV...AYPF.GGTINSAQIYQSVLSDEELKDITGV--tt.........................................................................
Q8XMY5_CLOPE/175-367                ...................elnvyeikgevdeianygnlkitkeeer-----------------LNITGDLEKFSS......LDEGTIVTRFNM-ND......T...SIQSLIGLSDGNKAN..NYFSLYV..S..GG..KVGYELRRQEGNG.DFNVHHS------ADVTFNKGINTLALKIE..-KGVGAKIFLNG.sLVKTVSDP..NIKF....LNA.I-.NLN.SG.FIGKTDRAN.gYN...EYLF.RGNIDFMNIYDKPVSDNYLLRKTGETK...........................................................................
F5WRH5_ERYRF/25-209                 ..............................ifamndlnlndlhlkge----------------GADISDHLSHIKE......FNQGSLTLRFRSESL......S..sDLTALFSISNANLEN..NYFALYY..Q..NStgKLGIEFRDETGKH.IINTSGT-STQLA----NANWHTVTVLNHG..---NRVEIYADG..IL-LASQD..NIDFt..kIQS.LP.-WN.RM.KVGGVARLK.gEN...LWPF.SGKISSLNLTHDILDVDT---------iktlhndt...................................................................
#=GC seq_cons                       .................................................................s.t.-Lsp.hp......LppuTIhlcF+ssss......s...sh.uLFSlSsupptN..pYFslal..p..ss..plGhEhRsppss...asstss..hpltss.hsp.s.sslshss-...pptphclalNG..llpphspp..stpF....Ips.ls.shs.ps.plGtTpRts..ps...tash.pGpIcphplYscsLos-pl.phot..............................................................................
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