GenomeNet

Database: Pfam
Entry: Sialidase
LinkDB: Sialidase
Original site: Sialidase 
#=GF ID   Sialidase
#=GF AC   PF02973.14
#=GF DE   Sialidase, N-terminal domain
#=GF PI   sialidase_N; 
#=GF AU   Griffiths-Jones SR
#=GF SE   Structural domain
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.50;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Glycoside_hydrolase_family_33
#=GF RN   [1]
#=GF RM   9562562
#=GF RT   The crystal structure of an intramolecular trans-sialidase with
#=GF RT   a NeuAc alpha2-->3Gal specificity. 
#=GF RA   Luo Y, Li SC, Chou MY, Li YT, Luo M; 
#=GF RL   Structure 1998;6:521-530.
#=GF DR   INTERPRO; IPR004124;
#=GF DR   SCOP; 1sli; fa;
#=GF SQ   21
#=GS E1M6C0_9STRE/134-212     AC E1M6C0.1
#=GS A0A075JSD0_9BACI/33-216  AC A0A075JSD0.1
#=GS NANA_STRR6/118-309       AC P62576.1
#=GS C0MCG2_STRS7/745-914     AC C0MCG2.1
#=GS R5QDP0_9FIRM/1004-1194   AC R5QDP0.1
#=GS E8K2T7_9STRE/166-357     AC E8K2T7.1
#=GS F9Q401_STROR/1-154       AC F9Q401.1
#=GS Q8CWP8_STRR6/42-228      AC Q8CWP8.1
#=GS S1R721_9ENTE/43-229      AC S1R721.1
#=GS R5QCN3_9FIRM/50-229      AC R5QCN3.1
#=GS G9RVR1_9FIRM/245-423     AC G9RVR1.1
#=GS E1M5K1_9STRE/122-274     AC E1M5K1.1
#=GS Q8XMG4_CLOPE/48-236      AC Q8XMG4.1
#=GS V4R195_STRIN/131-320     AC V4R195.1
#=GS F5WRH5_ERYRF/25-209      AC F5WRH5.1
#=GS K0YP92_9ACTO/16-197      AC K0YP92.1
#=GS E1M6B9_9STRE/1-97        AC E1M6B9.1
#=GS T1ZC06_STRIT/80-271      AC T1ZC06.1
#=GS R6V8Y4_9FIRM/45-239      AC R6V8Y4.1
#=GS Q8XMY5_CLOPE/175-367     AC Q8XMY5.1
#=GS Q8XMY5_CLOPE/175-367     DR PDB; 2V72 A; 133-138;
#=GS H3NDF0_9LACT/84-275      AC H3NDF0.1
E1M6C0_9STRE/134-212                ......................................................................................an--TVIEKE--DVETNPSNGQRVDMKEELDkl..kkLQNATIHMEFKPDAS......A..pRFYNLFSVSSDTKVN..EYFT---..-..--..-------------.------..----------------.----.-.---..-.-----------..----.--.--..-.-...--....---..--.-.-.-.-.-.-------.--...-....-...---.-.---------------------------wpslitqlslkv...............................................................
A0A075JSD0_9BACI/33-216             ...............................................................................epivsvene----------QIENGYFTNLNSEIDKLKK......LEEGTIVVRFRY-TG......S...SIMSLFSLSNSNLAN..GHFHLYI..S..PS..SIGSENRFQKPGEpQENVHT..SAAANLKEGHV-----.YTLA.M.VVD..-.KEAGYKYFLDG.eLIKE.DT.TS..P.R...KF....LNN..IH.K.P.N.S.A.QLGRTER.AA..gG....N...NYP.F.KGDIDFAKIYNQPLSDETLTAITGV--ts.........................................................................
NANA_STRR6/118-309                  ........................................................................................VETVIEKE--DVETNASNGQRVDLSSELDkl..kkLENATVHMEFKPDAK......A..pAFYNLFSVSSATKKD..EYFTMAV..Y..NN..TATLEGRGSDGKQ.FYNNYN..DAPLKVKPGQWNSVTF.TVEK.P.TAE..L.PKGRVRLYVNG..VLSR.TS.LR..S.G...NF....IKD..MP.D.V.T.H.V.QIGATKR.AN...N....T...VWG.S.NLQIRNLTVYNRALTPEEVQKRSQLFK...........................................................................
C0MCG2_STRS7/745-914                ...........................................................................dataekaavtdde-------------------ALSKLDDVMS......LNQGTVTIRYRLDTAdttvrsS...SPLALLSISNQASAN..EYASFFIepK..NN..KIGLEFKGAEVPI.VKVGSG..FNLL------------.----.-.---..-.-----------..----.--.--..-.-...--....---..--.-.-.-.-.-.-------.--...-....-...---.-.---------------------------tnsdwqtisyvftgsrlkiylngdlygeadfagfmkqlpwkasadtltigglkrtydgesvlhwglkglvdqvli
R5QDP0_9FIRM/1004-1194              ...................................................................frkedqkiavgspvelstkdy-----------------------AEKLMK......LEEGTILVHYTSTSD......Q...AIQSLFSVSNAKAGHenRHFHVYI..R..PE.gVLGCEIRNES-AM.NYGFKA..A--NAVKADYKGKPAE.NIIA.L.QAD..K.EKGTYQLFANGekVLTV.DA.AAlgG.Y...RF....ISE..IT.G.L.D.T.V.SLGATKR.GG...I....N...KYT.F.GGNIHKIEVYETPLTDEELIEETKK--ta.........................................................................
E8K2T7_9STRE/166-357                .......................................................................................v-NTVVEKN--DVTTNAENNQRDDLTSDLEkl..kkLQDATVHMEFKPDAS......A..pRFYNLFSVSSDTKEN..EYFTMSV..S..DN..TALIEGRDANGAQ.FYDKYT..DAPLKVRPGQWNSVTF.TVEK.P.TTE..V.PTGRVRLYVNG..VLSR.TS.LK..S.G...KF....IKD..MP.D.V.N.H.V.QIGATKR.GS...K....T...VWG.S.NLQVRNLTVYDRALTQDEVRTRSQLF-e..........................................................................
F9Q401_STROR/1-154                  ........................................................................................-----------------------------......-------MEFKPDAS......A..pRFYNLFSVSSDTKEN..EYFTMSV..L..DN..TALIEGRGANGEQ.FYDKYT..DAPLKVRPGQWNSVTF.TVEQ.P.TAE..L.PHGRVRLYVNG..VLSR.TS.LK..S.G...NF....IKD..MP.D.V.N.Q.A.QLGATKR.GN...K....T...VWA.S.NLQVRNLTVYDRALSPDEVQTRSQLF-e..........................................................................
Q8CWP8_STRR6/42-228                 ........................................................................................IFQGGSYQLNNKSIDISPLLLDKLSGDSQ......----TVVMKFKADKP......N...SLQALFGLSNSKAGFknNYFSIFM..R..DS.gEIGVEIRDAQKGI.NYLFSR..P--ASLWGKHKGQAVE.NTLV.F.VSD..S.KDKTYTMYVNG..-IEV.FS.ET..V.D...TFl..pISN..IN.G.I.D.K.A.TLGAVNR.EG...K....E...HYL.A.KGSIDEISLFNKAISDQEVSTIPLSN-p..........................................................................
S1R721_9ENTE/43-229                 .......................................................................................y--QSGPYILNNTGIDISDQVLNKIQGDNQ......----SIVLNFESSSP......N...SLQAIFGISNSNSGYrnNYFDIFM..R..NS.gEIGVEIRDAQKGV.NYLFAR..P--ASLWGIHKGNAVE.NTVV.F.TAN..A.TEKTYEMYVDG..-KCI.FS.KK..V.E...VFi..pING..IT.G.Q.N.N.A.MIGAVNR.EG...S....Q...AFT.M.NGKVNQLQIFNRVLTSSEISEH-----fsrenk.....................................................................
R5QCN3_9FIRM/50-229                 .......................................................................seeqqiqgidqrfeipq---------------------EDVSFVND......LGSGTITLSFKT-GS......T...NLQALAAINGDKHAN..HYMSLYI..S..GG.nKIGFEFRKNATVN.DHRNFT..VDNVNLADDQWH----.-TIT.L.AVE..-.KDSYYKVYLDQ.kLVQK.WE.VD..E.T...NF....VDK..MEwE.P.T.S.V.TFGGAKR.IS...G....N...SYP.F.TGSIKQVKLYNEAASEDQILA------dhgav......................................................................
G9RVR1_9FIRM/245-423                ...............................................................................yaaenivie----------------APSQAVELEQTLAgr.iaaLDEMTVIVKFKN-TN......T...GIGSLFSVSDPGQAA..AHFHIYQ..N..ND..RLGFEYRDRDD-P.FYEASC..T----IYAREW-----.NTVA.F.SAG..-.RDTGYRLFANG..ALGA.SL.EK..T.GadyRF....LSD..AA.S.W.S.S.C.SVGKTVR.GN..dP....E...GYP.F.TGTIERLEIYAGALPDEELAARTAQT-q..........................................................................
E1M5K1_9STRE/122-274                ........................................................................................VNTVLEKE--DVETNAANSNRIDLTEQLDkl..kqLQNATIHMEFKPDTS......A..pAFYNLFSVSSDTVRN..EYFTMAV..Y..NN..VALTEGRDQNGDQ.FYDRYT..DAPLTVKPGQWNSVTF.TVER.P.SAD..S.PDGQVRLYVNG..VLSR.TS.KK..S.G...RF....IKD..MP.D.V.-.-.-.-------.--...-....-...---.-.---------------------------iicklv.....................................................................
Q8XMG4_CLOPE/48-236                 ......................................................................................ls--SLGEYKDINLESSNASNITYDLEKYKN......LDEGTIVVRFNS-KD......S...KIQSLLGISNSKTKN..GYFNFYV..T..NS..RVGFELRNQKNEG.NTQSGT..ENLVHMYKDVALNDGD.NTVA.L.KIE..-.KNKGYKLFLNG.kIIKE.VK.DT..N.T...KF....LNN..IE.N.L.D.S.A.FIGKTNR.YG..qS....N...EYN.F.KGNIGFMNIYNEPLGDDYLLSKTGETK...........................................................................
V4R195_STRIN/131-320                .......................................................................aykenevfkidnqvlqk------------------NSKIDLSEHLDal..kkLDSATIYAEIKTPED......M..dDFMTWFSVSTSANEN..ERFYLYI..T..KE.gVVGVEGADNANKP.FYKSFT..SASQRVKPSEWN----.-ALA.F.VIN..Q.EAQKVQIYVNG..ILSQ.ED.ST..S.T...QF....IKD..LA.N.P.E.F.A.QIGQTQR.GR...S....N...KWG.FsHFDIKNFTVYNRALSETEVGDRSQLF-i..........................................................................
F5WRH5_ERYRF/25-209                 .......................................................................ifamndlnlndlhlkge----------------GADISDHLSHIKE......FNQGSLTLRFRSESL......S..sDLTALFSISNANLEN..NYFALYY..Q..NStgKLGIEFRDETGKH.IINTSG..T-STQLA----NANWH.TVTV.L.NHG..-.--NRVEIYADG..IL-L.AS.QD..N.I...DFt..kIQS..LP.-.W.N.R.M.KVGGVAR.LK..gE....N...LWP.F.SGKISSLNLTHDILDVDT---------iktlhndt...................................................................
K0YP92_9ACTO/16-197                 ..............................................................................lvevtnpysq---------------NAQGPGLDLVQYAPkv..ssLHSGTIAITFKTTQK......S...PSAALFSASSTKDPS..TNLTLSV..R..NG..HLYWEVRDQKLAP.ESWLAK..AD-AEDAGPVSDGSEH.AAVV.T.VS-..-.-DDNTRIYLDG..-QQV.FS.TA..A.R...AF....FSS..LN.Q.I.D.S.L.RLGANYD.NS...G....R...QWG.F.EGTISNASIYSSPLSAQQIRATT----kyp........................................................................
E1M6B9_9STRE/1-97                   .......................................................................................m-----------------------------......---------------......-...---------------..-------..-..--..-------------.------..----KIKPGEWNSVTF.TVER.P.NAD..Q.PKGQVRVYVNG..VLSR.TS.PQ..S.G...RF....IQD..MP.D.V.N.H.V.QIGTTKR.TG...K....N...FWG.A.NLKVRNLTVYDRALSQEEVKKRSQLF-e..........................................................................
T1ZC06_STRIT/80-271                 .......................................................................................v-QTIFEKE--NVVTNDSNNQRIDLSGELDkl..kqLQTATIHIEFKADAN......A..pRFYNLFSVSSDKVKN..EYFTMAV..Y..NN..TAIVEGRDKDGKQ.FYNSYN..DAPLKIKSGQWNSVTF.TVDG.P.NSD..H.PNGQVRLYVNG..VLSR.TS.KL..S.G...RF....IKD..MP.D.V.N.H.V.QIGKTNR.AR...S....M...MWG.S.NLHVRNLTVYNRALTSEEVQKRSQLFK...........................................................................
R6V8Y4_9FIRM/45-239                 ...............................................................................iqnglvfeq-----------NNIDIVQGQGYDVSSEEGaeyveaLSEGTIIISFKSTSQ......N...QYQSLISIGNNRTGNqnRHFHLYI..T..NT.gAVGMELRNTDSVF.KYTLSR..P--AALRSKYKNEYVS.NTVA.F.KAD..R.ENHQYKLFANG.eLLAT.LD.KE..D.F...KF....ISD..IT.E.V.N.N.V.MLGGTNR.QG...T....V...AYP.F.GGTINSAQIYQSVLSDEELKDITGV--tt.........................................................................
Q8XMY5_CLOPE/175-367                ............................................................elnvyeikgevdeianygnlkitkeeer-----------------LNITGDLEKFSS......LDEGTIVTRFNM-ND......T...SIQSLIGLSDGNKAN..NYFSLYV..S..GG..KVGYELRRQEGNG.DFNVHH..S------ADVTFNKGI.NTLA.L.KIE..-.KGVGAKIFLNG.sLVKT.VS.DP..N.I...KF....LNA..I-.N.L.N.S.G.FIGKTDR.AN..gY....N...EYL.F.RGNIDFMNIYDKPVSDNYLLRKTGETK...........................................................................
#=GR Q8XMY5_CLOPE/175-367     SS    ............................................................EEEEE-XXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXXXXX......XXXXXXXXXXXX-XX......X...XXXXXXXXXXXXXXX..XXXXXXX..X..XX..XXXXXXXXXXXXX.XXXXXX..X------XXXXXXXXX.XXXX.X.XXX..-.XXXXXXXXXXX.XXXXX.XX.XX..X.X...XX....XXX..X-.X.X.X.X.X.XXXXXXX.XX..XX....X...XXX.X.XXXXXXXXXXXXXXXXXXXXXXXXXXX...........................................................................
H3NDF0_9LACT/84-275                 ........................................................................essiqpkyhsenvdls------------------NDGYDVEKPDDv...ltAENQTVTIEYSSLHK......A...KLQAIVGYSNDQNDQtnNYFSLYV..R..DD.gTAGFELRSPKHGV.NYLYER..P--AAVAGKRNGEMAT.NKLA.F.VAD..R.ENKRYKLFANG..-VKI.ID.QQ..V.K...NYv..gLND..LE.K.L.N.S.F.TLGGVKR.NK...A....L...AYG.F.TGTIQQYNAVGTALTDEELKKHTQVN-d..........................................................................
#=GC SS_cons                        ............................................................EEEEE-XXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXXXXX......XXXXXXXXXXXX-XX......X...XXXXXXXXXXXXXXX..XXXXXXX..X..XX..XXXXXXXXXXXXX.XXXXXX..X------XXXXXXXXX.XXXX.X.XXX..-.XXXXXXXXXXX.XXXXX.XX.XX..X.X...XX....XXX..X-.X.X.X.X.X.XXXXXXX.XX..XX....X...XXX.X.XXXXXXXXXXXXXXXXXXXXXXXXXXX...........................................................................
#=GC seq_cons                       ..........................................................................................................s.t.-lpp.hs......LppuTlhhcF+ssss......s...sh.uLFSlSsspptN..pYFshal..p..ss..plGhEhRsppst...aphhs..s..hpltssphsp.s..sshs.h.ss-.....psph+lalNG..llpt.hs.pp..s.t...pF....lps..hs.s.l.s.p.s.plGtspR.ts...t....p...has.h.phpIpphplYspsLos-pltppot..............................................................................
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