GenomeNet

Database: Pfam
Entry: SopE_GEF
LinkDB: SopE_GEF
Original site: SopE_GEF 
#=GF ID   SopE_GEF
#=GF AC   PF07487.10
#=GF DE   SopE GEF domain
#=GF AU   Finn RD, Moxon SJ
#=GF SE   Pfam-B_18665 (release 7.8)
#=GF GA   20.00 20.00;
#=GF TC   21.30 23.30;
#=GF NC   19.80 17.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12093730
#=GF RT   Structural basis for the reversible activation of a Rho protein
#=GF RT   by the bacterial toxin SopE. 
#=GF RA   Buchwald G, Friebel A, Galan JE, Hardt WD, Wittinghofer A,
#=GF RA   Scheffzek K; 
#=GF RL   EMBO J 2002;21:3286-3295.
#=GF DR   INTERPRO; IPR016019;
#=GF DR   SCOP; 1gzs; fa;
#=GF CC   This family represents the C-terminal guanine nucleotide
#=GF CC   exchange factor (GEF) domain of SopE. Salmonella typhimurium
#=GF CC   employs a type III secretion system to inject bacterial toxins
#=GF CC   into the host cell cytosol. These toxins transiently activate
#=GF CC   Rho family GTP-binding protein-dependent signaling cascades to
#=GF CC   induce cytoskeletal rearrangements. SopE, can activate Cdc42, an
#=GF CC   essential component of the host cellular signaling cascade, in a
#=GF CC   Dbl-like fashion despite its lack of sequence similarity to
#=GF CC   Dbl-like proteins, the Rho-specific eukaryotic guanine
#=GF CC   nucleotide exchange factors [1].
#=GF SQ   5
#=GS W8U3B0_YEREN/1-126    AC W8U3B0.1
#=GS Q7P1B7_CHRVO/84-241   AC Q7P1B7.1
#=GS C4K8Y0_HAMD5/307-476  AC C4K8Y0.1
#=GS BOPE_BURPS/85-245     AC Q63K41.1
#=GS BOPE_BURPS/85-245     DR PDB; 2JOL A; 85-245;
#=GS BOPE_BURPS/85-245     DR PDB; 2JOK A; 85-245;
#=GS SOPE2_SALTY/76-240    AC Q7CQD4.3
#=GS SOPE2_SALTY/76-240    DR PDB; 1R9K A; 76-240;
#=GS SOPE2_SALTY/76-240    DR PDB; 1R6E A; 76-240;
W8U3B0_YEREN/1-126               .....................m---------------------------------------LASVYSNKKDVFCKEMISKGIDISG.YLKDVGAAALQAGLE.GKIDNnDTFIPTGAGANPFVTAVISSAQLKFP.LVFLNKNQQGFFK...QYAEKKISCEVGKICKDNGFISPVEFGVMLDKIASRYL----ls.............................................................
Q7P1B7_CHRVO/84-241              ............plspgdvkam-----------IRSRLDSL---RDGMADPVYRRQALESTYATIYSEAKQAFYRA--NGGKMPEG.YLRELGEAARAAGLP.GENKH.GVFIPSGDGASPFVNYLLIPVQKEFG.HRLRNESQQRLFR...DFARQLSMELVAPHAAERGWEPPAAFAARLEAVGRPWL----aqa............................................................
C4K8Y0_HAMD5/307-476             alfnsellklskllklpegksi---------------------FDEAKYNQTTRNQLIDAGLASVYAQKIDDFKKKYGESSETGQK.FLFEIGKVCKENGVKcTQNKN.GTWVVNGAGAHPVIYPISQNIFTKFKmHLKLSNNKTKMYDksiSYITNKVYKKTDELCKQENRITTSD-----------------lrsllddvekkvldgt...............................................
BOPE_BURPS/85-245                ..irhfvdeavkqvahartpei-------------------------RQDAEFGRQVYEATLCAIFSEAKDRFCMDPATRAGNVRPaFIEALGDAARATGLP.GADKQ.GVFTPSGAGTNPLYTEIR--------.-------------...------------------------------------------lradtlmgaelaarpeyrelqpyarqqaidlvanalpaersntlvefrqtvqtleatyrraaq
#=GR BOPE_BURPS/85-245     SS    ..HHHHHHHHHHHHHCHHHHHH-------------------------HSGGGSSSSSHHHHHHHHHHHHHHCT-S-EEETTEEE--S--S-SCHHHHHHHHH.HHTTH.HHSCHHCC-SHHHHHHHH--------.-------------...------------------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
SOPE2_SALTY/76-240               ......................AVLTSKTVKDFMLQKLNSLDIKGNASKDPAYARQTCEAILSAVYSNNKDQCCKLLISKGVSITP.FLKEIGEAAQNAGLP.GEIKN.GVFTPGGAGANPFVVPLIASASIKYP.HMFINHNQQVSFK...AYAEKIVMKEVTPLFNKGTMPTPQQFQLTIENIANKYLQNAS...............................................................
#=GR SOPE2_SALTY/76-240    SS    ......................HHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT--HHHHHHHHHHHHHHTT--EEE-SS-.EETT-SS-TTHHHHH.HHHHH.HHHHSSCCHHHHHHHHHHHHHHHHHG.GGTSSS---HHHH...HHHHHHHHHHTT-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX...............................................................
#=GC SS_cons                     ..HHHHHHHHHHHHHCHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHCHHHCCCCCHCHHHHHHHHHHHHCCHCTCEECCEECS-SEETTSCCHCCHHHHH.HHCCH.HHCCCCCCHCHHHHHHHHHHHHHHHG.GGTSSS---HHHH...HHHHHHHHHHTT-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX...............................................................
#=GC seq_cons                    .............lt.scs.th......................tpuptDssatRQshEAsLAoVYSpsKDsFCKchho+Gtslps.FL+ElG-AA+sAGLP.GcsKN.GVFlPoGAGANPFVsslltssphKFs.HhhlNcNQQthF+...sYAcphlhccVs.lspcpsh.oPspFthhl-tlup.aL....Lpu............................................................
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