GenomeNet

Database: Pfam
Entry: SopE_GEF
LinkDB: SopE_GEF
Original site: SopE_GEF 
#=GF ID   SopE_GEF
#=GF AC   PF07487.11
#=GF DE   SopE GEF domain
#=GF AU   Finn RD, Moxon SJ
#=GF SE   Pfam-B_18665 (release 7.8)
#=GF GA   20.00 20.00;
#=GF TC   21.30 23.30;
#=GF NC   19.80 17.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12093730
#=GF RT   Structural basis for the reversible activation of a Rho protein
#=GF RT   by the bacterial toxin SopE. 
#=GF RA   Buchwald G, Friebel A, Galan JE, Hardt WD, Wittinghofer A,
#=GF RA   Scheffzek K; 
#=GF RL   EMBO J 2002;21:3286-3295.
#=GF DR   INTERPRO; IPR016019;
#=GF DR   SCOP; 1gzs; fa;
#=GF CC   This family represents the C-terminal guanine nucleotide
#=GF CC   exchange factor (GEF) domain of SopE. Salmonella typhimurium
#=GF CC   employs a type III secretion system to inject bacterial toxins
#=GF CC   into the host cell cytosol. These toxins transiently activate
#=GF CC   Rho family GTP-binding protein-dependent signaling cascades to
#=GF CC   induce cytoskeletal rearrangements. SopE, can activate Cdc42, an
#=GF CC   essential component of the host cellular signaling cascade, in a
#=GF CC   Dbl-like fashion despite its lack of sequence similarity to
#=GF CC   Dbl-like proteins, the Rho-specific eukaryotic guanine
#=GF CC   nucleotide exchange factors [1].
#=GF SQ   7
#=GS W8U3B0_YEREN/1-126       AC W8U3B0.1
#=GS Q7P1B7_CHRVO/84-241      AC Q7P1B7.1
#=GS A9MNG9_SALAR/76-240      AC A9MNG9.1
#=GS C4K8Y0_HAMD5/307-476     AC C4K8Y0.1
#=GS BOPE_BURPS/85-245        AC Q63K41.1
#=GS BOPE_BURPS/85-245        DR PDB; 2JOL A; 85-245;
#=GS BOPE_BURPS/85-245        DR PDB; 2JOK A; 85-245;
#=GS SOPE2_SALTY/76-240       AC Q7CQD4.3
#=GS SOPE2_SALTY/76-240       DR PDB; 1R9K A; 76-240;
#=GS SOPE2_SALTY/76-240       DR PDB; 1R6E A; 76-240;
#=GS A0A0N1J5N7_9PSED/79-215  AC A0A0N1J5N7.1
W8U3B0_YEREN/1-126                  .....................m---------------------------------------LASVYSNKKDVFCKEMISKGI...DISG.YLKDVGAAALQAGLE.GKI.DNnDTFIPTGA..GANPFVTAVISSAQLKFP.LVFLNKNQQGFFK...QYAEKKISCEVGKICKDNGFISPVEFGVMLDKIASRYL----ls.............................................................
Q7P1B7_CHRVO/84-241                 ............plspgdvkam-----------IRSRLDSL---RDGMADPVYRRQALESTYATIYSEAKQAFYRA--NGGK...MPEG.YLRELGEAARAAGLP.GEN.KH.GVFIPSGD..GASPFVNYLLIPVQKEFG.HRLRNESQQRLFR...DFARQLSMELVAPHAAERGWEPPAAFAARLEAVGRPWL----aqa............................................................
A9MNG9_SALAR/76-240                 ......................AVLTNKIVKDFMLQKLNSLDIKGNASKDPDYARQTCEAMLSSVYSNNKDQCCKLLVSKGI...SITP.FLKEIGEAAQNAGLP.GEI.KN.GIFTPGGA..GTNPFVVPLIASASVEYP.HMFINYSQQVSFK...AYAEKIIMKEVTPLFNEGTMPTPQQFQLTVENIANKYLQNAS...............................................................
C4K8Y0_HAMD5/307-476                alfnsellklskllklpegksi---------------------FDEAKYNQTTRNQLIDAGLASVYAQKIDDFKKKYGESSE...TGQK.FLFEIGKVCKENGVKcTQN.KN.GTWVVNGA..GAHPVIYPISQNIFTKFKmHLKLSNNKTKMYDksiSYITNKVYKKTDELCKQENRITTSD-----------------lrsllddvekkvldgt...............................................
BOPE_BURPS/85-245                   ..irhfvdeavkqvahartpei-------------------------RQDAEFGRQVYEATLCAIFSEAKDRFCMDPATRAG...NVRPaFIEALGDAARATGLP.GAD.KQ.GVFTPSGA..GTNPLYTEIR--------.-------------...------------------------------------------lradtlmgaelaarpeyrelqpyarqqaidlvanalpaersntlvefrqtvqtleatyrraaq
#=GR BOPE_BURPS/85-245        SS    ..HHHHHHHHHHHHHHHCHHHH-------------------------HHTTTHHHHHHHHHHHHHHHHHHHHHHHSGGGSSS...SSHHHHHHHHHHHHHHCT-S.-EE.ET.TEEE--S-..-S-SCHHHHH--------.-------------...------------------------------------------HHHHHHHTTHHHHSCHHCC-SHHHHHHHHHHHHHTSTCHHHHHHHHHHHHHHHHHHHHHHHHH
SOPE2_SALTY/76-240                  ......................AVLTSKTVKDFMLQKLNSLDIKGNASKDPAYARQTCEAILSAVYSNNKDQCCKLLISKGV...SITP.FLKEIGEAAQNAGLP.GEI.KN.GVFTPGGA..GANPFVVPLIASASIKYP.HMFINHNQQVSFK...AYAEKIVMKEVTPLFNKGTMPTPQQFQLTIENIANKYLQNAS...............................................................
#=GR SOPE2_SALTY/76-240       SS    ......................S---SSSHHHHHHHHHHHHTHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-...-HHH.HHHHHHHHHHHTT--.EEE.-S.S-EEETT-..SS-TTHHHHHHHHHHH-H.HHHSSCCHHHHHH...HHHHHHHHHHHGGGGTSSS---HHHHHHHHHHHHHHHHHTT-...............................................................
A0A0N1J5N7_9PSED/79-215             .......anlkdqidptdpknr------------------------------------EELVAGCFTLIHDNCEKLVDKQKMpsdQALS.FKQQLGRLAWKVGLP.GEAnKQ.GVFVPRGAgsGANPLLNPLKDLILREHA.HIFKHPVLREKIF...AMAEKKIIAFVSDHMN--------------------------peeskrldcfqhe..................................................
#=GC SS_cons                        ..HHHHHHHHHHHHHHHCHHHHS---SSSHHHHHHHHHHHHTHHHHHHHTCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCTS...SCHHHHHHHHHHHHHHCT-S.EEE.ET.TEEEETT-..SS-TCHHHHHHHHHHH-H.HHHSSCCHHHHHH...HHHHHHHHHHHGGGGTSSS---HHHHHHHHHHHHHHHHHTT-HHHHHHHTTHHHHSCHHCC.SHHHHHHHHHHHHHTSTCHHHHHHHHHHHHHHHHHHHHHHHHH
#=GC seq_cons                       .....................h...........................s..htpQhhEuhLuulYSptKDphpKhhhspuh...shps.FLc-lGcAAppsGLP.Gc..Kp.GlFsPsGA..GANPhlsslhtsh.hcas.Hhhhs.spph.ac...saAcphlhp.Vs.hhpptsh.ss.t..................p.............................................................
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