GenomeNet

Database: Pfam
Entry: TBD
LinkDB: TBD
Original site: TBD 
#=GF ID   TBD
#=GF AC   PF12845.3
#=GF DE   TBD domain
#=GF AU   Bateman A, Masci AM
#=GF SE   [1]
#=GF GA   21.40 21.40;
#=GF TC   22.50 21.90;
#=GF NC   19.90 18.70;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17568778
#=GF RT   SINTBAD, a novel component of innate antiviral immunity, shares
#=GF RT   a TBK1-binding domain with NAP1 and TANK.
#=GF RA   Ryzhakov G, Randow F;
#=GF RL   EMBO J. 2007;26:3180-3190.
#=GF DR   INTERPRO; IPR024581;
#=GF CC   The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain
#=GF CC   able to bind kinases, has been found to be essential for
#=GF CC   poly(I:C)-induced IRF activation [1]. The domain is found in
#=GF CC   SINTBAD, TANK and NAP1 protein. This domain is predicted to form
#=GF CC   an a-helix with residues essential for kinase binding clustering
#=GF CC   on one side [1].
#=GF SQ   222
#=GS Z4YKN2_MOUSE/288-342      AC Z4YKN2.1
#=GS K9IIJ7_DESRO/172-224      AC K9IIJ7.1
#=GS M4AAF2_XIPMA/110-165      AC M4AAF2.1
#=GS E2RLY7_CANFA/168-222      AC E2RLY7.2
#=GS H2M9R1_ORYLA/267-324      AC H2M9R1.1
#=GS G3QIP7_GORGO/147-201      AC G3QIP7.1
#=GS S7MGJ8_MYOBR/153-207      AC S7MGJ8.1
#=GS W5M2Z8_LEPOC/215-268      AC W5M2Z8.1
#=GS M3XN89_MUSPF/152-206      AC M3XN89.1
#=GS AZI2_HUMAN/213-265        AC Q9H6S1.1
#=GS H2U837_TAKRU/253-306      AC H2U837.1
#=GS G3QIG2_GORGO/288-342      AC G3QIG2.1
#=GS F6ZSV9_XENTR/194-251      AC F6ZSV9.1
#=GS AZI2_BOVIN/214-266        AC Q3SYW5.1
#=GS G3NQ65_GASAC/108-163      AC G3NQ65.1
#=GS G3RRH2_GORGO/213-265      AC G3RRH2.1
#=GS TBKB1_HUMAN/288-342       AC A7MCY6.1
#=GS H2NVF5_PONAB/312-366      AC H2NVF5.1
#=GS I3KPA6_ORENI/292-352      AC I3KPA6.1
#=GS F7AZG4_ORNAN/150-205      AC F7AZG4.1
#=GS Q4ZG76_HUMAN/99-153       AC Q4ZG76.1
#=GS K9IXQ6_DESRO/132-186      AC K9IXQ6.1
#=GS W5KL41_ASTMX/313-369      AC W5KL41.1
#=GS U3IJV4_ANAPL/130-185      AC U3IJV4.1
#=GS F7DLM0_MONDO/180-234      AC F7DLM0.2
#=GS F1LQL4_RAT/226-279        AC F1LQL4.2
#=GS Q4JQQ1_XENLA/192-249      AC Q4JQQ1.1
#=GS F7FH52_MONDO/214-266      AC F7FH52.2
#=GS F7DUU2_XENTR/277-330      AC F7DUU2.1
#=GS G7MJZ3_MACMU/213-267      AC G7MJZ3.1
#=GS I3N5U4_SPETR/214-266      AC I3N5U4.1
#=GS H9EZA5_MACMU/288-340      AC H9EZA5.1
#=GS G3WTC1_SARHA/150-204      AC G3WTC1.1
#=GS H0WQY5_OTOGA/133-187      AC H0WQY5.1
#=GS G3NI57_GASAC/263-317      AC G3NI57.1
#=GS AZI2_MOUSE/226-278        AC Q9QYP6.1
#=GS G1QLY4_NOMLE/16-61        AC G1QLY4.1
#=GS G7NYA6_MACFA/213-267      AC G7NYA6.1
#=GS H3BCD3_LATCH/214-269      AC H3BCD3.1
#=GS H0Z8E4_TAEGU/128-183      AC H0Z8E4.1
#=GS G1U0B2_RABIT/209-260      AC G1U0B2.1
#=GS W5UJD7_ICTPU/128-184      AC W5UJD7.1
#=GS H0WT23_OTOGA/214-266      AC H0WT23.1
#=GS H0VSY8_CAVPO/154-206      AC H0VSY8.1
#=GS D2H3M5_AILME/214-266      AC D2H3M5.1
#=GS Q8C2D3_MOUSE/130-184      AC Q8C2D3.1
#=GS F6WYF7_CALJA/213-265      AC F6WYF7.1
#=GS G5GM29_9FIRM/43-80        AC G5GM29.1
#=GS W5PYW5_SHEEP/214-266      AC W5PYW5.1
#=GS Q4R5I0_MACFA/132-186      AC Q4R5I0.1
#=GS U3JPD5_FICAL/128-183      AC U3JPD5.1
#=GS TBKB1_MOUSE/289-343       AC A2A9T0.1
#=GS I3J5Z3_ORENI/291-334      AC I3J5Z3.1
#=GS G3X1J5_SARHA/287-341      AC G3X1J5.1
#=GS L8IJL2_9CETA/164-218      AC L8IJL2.1
#=GS V9KT79_CALMI/222-276      AC V9KT79.1
#=GS W5KRN8_ASTMX/130-185      AC W5KRN8.1
#=GS S7Q2D8_MYOBR/213-265      AC S7Q2D8.1
#=GS F6SY96_MOUSE/1-51         AC F6SY96.1
#=GS K9IK54_DESRO/214-266      AC K9IK54.1
#=GS W5PA13_SHEEP/168-222      AC W5PA13.1
#=GS L5L4J0_PTEAL/214-266      AC L5L4J0.1
#=GS W5MQ08_LEPOC/138-193      AC W5MQ08.1
#=GS H3DHU3_TETNG/247-291      AC H3DHU3.1
#=GS H2U838_TAKRU/249-302      AC H2U838.1
#=GS U3K3G7_FICAL/216-270      AC U3K3G7.1
#=GS H2QDA4_PANTR/288-342      AC H2QDA4.1
#=GS M3YV01_MUSPF/287-332      AC M3YV01.1
#=GS F7GD69_MACMU/213-267      AC F7GD69.1
#=GS G5BT21_HETGA/68-122       AC G5BT21.1
#=GS M3YKM1_MUSPF/250-302      AC M3YKM1.1
#=GS K7F8Z7_PELSI/146-201      AC K7F8Z7.1
#=GS A2AR76_MOUSE/164-218      AC A2AR76.1
#=GS L8J117_9CETA/214-265      AC L8J117.1
#=GS D3DTT5_HUMAN/288-342      AC D3DTT5.1
#=GS H0YZD3_TAEGU/222-275      AC H0YZD3.1
#=GS W5PEZ8_SHEEP/287-341      AC W5PEZ8.1
#=GS F7G3B1_MACMU/132-186      AC F7G3B1.1
#=GS W5N737_LEPOC/281-328      AC W5N737.1
#=GS Q4SCJ8_TETNG/50-104       AC Q4SCJ8.1
#=GS E1BU10_CHICK/218-271      AC E1BU10.2
#=GS H0XPA9_OTOGA/228-279      AC H0XPA9.1
#=GS D3Z7S3_MOUSE/79-131       AC D3Z7S3.1
#=GS I3LKX7_PIG/213-265        AC I3LKX7.1
#=GS E7ENY2_HUMAN/133-187      AC E7ENY2.1
#=GS Q8VDA2_RAT/131-185        AC Q8VDA2.1
#=GS G3T829_LOXAF/102-156      AC G3T829.1
#=GS U6E0Z0_NEOVI/103-157      AC U6E0Z0.1
#=GS H7C1Z1_HUMAN/11-61        AC H7C1Z1.1
#=GS G1KG46_ANOCA/281-342      AC G1KG46.1
#=GS B2R7S3_HUMAN/132-186      AC B2R7S3.1
#=GS G9KSD5_MUSPF/63-117       AC G9KSD5.1
#=GS I3J5Z4_ORENI/291-334      AC I3J5Z4.1
#=GS U6CZ11_NEOVI/1-52         AC U6CZ11.1
#=GS G1NF49_MELGA/235-279      AC G1NF49.1
#=GS F7GD78_MACMU/213-265      AC F7GD78.1
#=GS L5MH72_MYODS/304-343      AC L5MH72.1
#=GS I3J5Z2_ORENI/291-334      AC I3J5Z2.1
#=GS Q6NW12_HUMAN/132-186      AC Q6NW12.1
#=GS H2U839_TAKRU/251-304      AC H2U839.1
#=GS F1M101_RAT/131-185        AC F1M101.2
#=GS Q08CI3_DANRE/126-180      AC Q08CI3.1
#=GS H2P7M8_PONAB/131-185      AC H2P7M8.1
#=GS H0Y0C3_OTOGA/288-342      AC H0Y0C3.1
#=GS M7BH81_CHEMY/197-258      AC M7BH81.1
#=GS AZI2_PONAB/213-265        AC Q5RD40.1
#=GS E1C5I0_CHICK/190-245      AC E1C5I0.2
#=GS K7G4G0_PELSI/79-128       AC K7G4G0.1
#=GS H2QM81_PANTR/213-265      AC H2QM81.1
#=GS Q8R383_MOUSE/130-184      AC Q8R383.1
#=GS H2TA08_TAKRU/262-307      AC H2TA08.1
#=GS W5M313_LEPOC/228-282      AC W5M313.1
#=GS M3ZAV8_NOMLE/243-295      AC M3ZAV8.1
#=GS S7N9N1_MYOBR/101-153      AC S7N9N1.1
#=GS B7ZS21_XENLA/192-249      AC B7ZS21.1
#=GS U3D3M6_CALJA/288-342      AC U3D3M6.1
#=GS Q4RNN8_TETNG/363-416      AC Q4RNN8.1
#=GS M3WDK4_FELCA/288-342      AC M3WDK4.1
#=GS S3NAH1_9GAMM/221-261      AC S3NAH1.1
#=GS Q3UGW0_MOUSE/131-185      AC Q3UGW0.1
#=GS G1LDC5_AILME/307-359      AC G1LDC5.1
#=GS Q3TNB4_MOUSE/130-184      AC Q3TNB4.1
#=GS K9K446_HORSE/203-255      AC K9K446.1
#=GS H2QIV9_PANTR/132-186      AC H2QIV9.1
#=GS H0Z8D8_TAEGU/66-121       AC H0Z8D8.1
#=GS F7A092_MOUSE/153-197      AC F7A092.1
#=GS G1TNR4_RABIT/132-186      AC G1TNR4.1
#=GS G1NEX6_MELGA/130-185      AC G1NEX6.1
#=GS M3ZC42_NOMLE/190-244      AC M3ZC42.1
#=GS H3BD49_LATCH/291-345      AC H3BD49.1
#=GS TANK_HUMAN/132-186        AC Q92844.2
#=GS TANK_HUMAN/132-186        DR PDB; 1KZZ B; 1-10;
#=GS TANK_HUMAN/132-186        DR PDB; 1L0A B; 1-9;
#=GS G1QVJ4_NOMLE/213-265      AC G1QVJ4.1
#=GS E2RLT7_CANFA/214-266      AC E2RLT7.2
#=GS G3SNE1_LOXAF/288-341      AC G3SNE1.1
#=GS L5LRP8_MYODS/132-186      AC L5LRP8.1
#=GS F6R2Z7_BOVIN/132-186      AC F6R2Z7.1
#=GS E7FAL4_DANRE/126-171      AC E7FAL4.1
#=GS H3CZR8_TETNG/256-308      AC H3CZR8.1
#=GS I3MAC0_SPETR/149-203      AC I3MAC0.1
#=GS G1KPN5_ANOCA/227-282      AC G1KPN5.2
#=GS I3NBS2_SPETR/230-280      AC I3NBS2.1
#=GS D2HPY4_AILME/132-186      AC D2HPY4.1
#=GS R0J8K2_ANAPL/1-52         AC R0J8K2.1
#=GS V9LCQ9_CALMI/209-253      AC V9LCQ9.1
#=GS M3WSX4_FELCA/220-272      AC M3WSX4.1
#=GS G3NPU7_GASAC/259-304      AC G3NPU7.1
#=GS F7AZB3_ORNAN/135-188      AC F7AZB3.1
#=GS F7AQP5_MACMU/288-342      AC F7AQP5.1
#=GS H0VQS5_CAVPO/214-266      AC H0VQS5.1
#=GS G3X0K7_SARHA/229-279      AC G3X0K7.1
#=GS K7GPD1_PIG/131-185        AC K7GPD1.1
#=GS F6RX86_XENTR/233-277      AC F6RX86.1
#=GS E6ZI15_DICLA/301-351      AC E6ZI15.1
#=GS TBKB1_RAT/289-343         AC Q6DG50.1
#=GS E7EQA9_HUMAN/132-186      AC E7EQA9.1
#=GS E6ZI16_DICLA/293-341      AC E6ZI16.1
#=GS F6YBK2_CALJA/132-186      AC F6YBK2.1
#=GS H0XIS9_OTOGA/205-254      AC H0XIS9.1
#=GS F7BNJ6_HORSE/132-155      AC F7BNJ6.1
#=GS G1PQ89_MYOLU/296-350      AC G1PQ89.1
#=GS G7PKN6_MACFA/132-186      AC G7PKN6.1
#=GS M4AGT4_XIPMA/253-308      AC M4AGT4.1
#=GS M1EJC2_MUSPF/276-328      AC M1EJC2.1
#=GS G1T8F3_RABIT/214-266      AC G1T8F3.1
#=GS H2PBA6_PONAB/213-265      AC H2PBA6.2
#=GS F1PEY1_CANFA/148-202      AC F1PEY1.2
#=GS G1QF19_MYOLU/201-245      AC G1QF19.1
#=GS A0A024R2K9_HUMAN/213-262  AC A0A024R2K9.1
#=GS V2UHI5_9GAMM/221-261      AC V2UHI5.1
#=GS E7EW82_HUMAN/191-236      AC E7EW82.1
#=GS G7PU58_MACFA/286-337      AC G7PU58.1
#=GS G5B981_HETGA/214-266      AC G5B981.1
#=GS M3W2U2_FELCA/132-186      AC M3W2U2.1
#=GS G9KSM5_MUSPF/12-66        AC G9KSM5.1
#=GS E7FGU2_DANRE/285-338      AC E7FGU2.1
#=GS B7ZS25_XENLA/192-249      AC B7ZS25.1
#=GS H3BCD2_LATCH/215-270      AC H3BCD2.1
#=GS I3KPA7_ORENI/249-297      AC I3KPA7.1
#=GS Q0VD25_BOVIN/164-218      AC Q0VD25.1
#=GS F6ZGI5_ORNAN/214-266      AC F6ZGI5.1
#=GS F7IND3_CALJA/288-342      AC F7IND3.1
#=GS TANK_MOUSE/165-219        AC P70347.1
#=GS W5KT29_ASTMX/287-367      AC W5KT29.1
#=GS J9P6W5_CANFA/132-186      AC J9P6W5.1
#=GS K6ZPU5_PANTR/213-265      AC K6ZPU5.1
#=GS E1BM04_BOVIN/288-342      AC E1BM04.1
#=GS G1QMY3_NOMLE/132-186      AC G1QMY3.1
#=GS V9L0P1_CALMI/9-62         AC V9L0P1.1
#=GS V9KR41_CALMI/180-234      AC V9KR41.1
#=GS H7C3L4_HUMAN/23-77        AC H7C3L4.1
#=GS G1NUH1_MYOLU/168-222      AC G1NUH1.1
#=GS U3CVK9_CALJA/288-342      AC U3CVK9.1
#=GS E7EVA2_HUMAN/190-235      AC E7EVA2.1
#=GS I3KPA8_ORENI/257-311      AC I3KPA8.1
#=GS I3N9C9_SPETR/230-280      AC I3N9C9.1
#=GS V8PA87_OPHHA/195-250      AC V8PA87.1
#=GS H9GRY7_ANOCA/194-248      AC H9GRY7.2
#=GS L8YBM5_TUPCH/1253-1305    AC L8YBM5.1
#=GS H3C5J3_TETNG/121-175      AC H3C5J3.1
#=GS L5JQA2_PTEAL/287-332      AC L5JQA2.1
#=GS N8YX71_ACIBZ/223-261      AC N8YX71.1
#=GS G1M155_AILME/168-222      AC G1M155.1
#=GS G7NH58_MACMU/286-333      AC G7NH58.1
#=GS U3IY28_ANAPL/221-271      AC U3IY28.1
#=GS F1RWJ4_PIG/288-342        AC F1RWJ4.1
#=GS G5BT31_HETGA/132-186      AC G5BT31.1
#=GS AZI2_MACFA/213-265        AC Q4R3X1.1
#=GS F1RPR5_PIG/132-186        AC F1RPR5.2
#=GS G1TLY1_RABIT/288-342      AC G1TLY1.2
#=GS F7E486_HORSE/214-266      AC F7E486.1
#=GS K7GMI6_PIG/287-341        AC K7GMI6.1
#=GS K7FCI2_PELSI/214-269      AC K7FCI2.1
#=GS AZI2_RAT/226-277          AC Q4KMA0.1
#=GS H2SKW7_TAKRU/123-177      AC H2SKW7.1
#=GS R0JXY3_ANAPL/235-296      AC R0JXY3.1
#=GS G3H5V0_CRIGR/1793-1838    AC G3H5V0.1
#=GS G1M217_AILME/226-278      AC G1M217.1
#=GS G1NSE3_MYOLU/225-277      AC G1NSE3.1
#=GS L5K2B2_PTEAL/132-186      AC L5K2B2.1
#=GS A2AR78_MOUSE/130-184      AC A2AR78.1
#=GS A1L1J0_RAT/130-184        AC A1L1J0.1
#=GS F1P609_CANFA/288-336      AC F1P609.2
Z4YKN2_MOUSE/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNA...G-...........QRHSPLSQRH-s...............................
K9IIJ7_DESRO/172-224                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACAPVGCVED................................
M4AAF2_XIPMA/110-165                 .....ssd---YQDMLAAFEAIQGKFRQIQTLTTKQKHHLKRFHGSYDNSN...DQ...........RFSMPIQCTD-g...............................
E2RLY7_CANFA/168-222                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPIQCTDK................................
H2M9R1_ORYLA/267-324                 ........GDEQVNLALAYTELTEELGRLRALSAKQTEILRKATQEQASPG...GE...........-----------hkhplrfntptqq...................
G3QIP7_GORGO/147-201                 .......l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
S7MGJ8_MYOBR/153-207                 .......f-HERSYIEKTFWDLKEEFHRICLLAKAQKDHLSKLNVS-ATAA...ET...........QCSVPIQCTDK................................
W5M2Z8_LEPOC/215-268                 .....das------LLKTYVDLRREMSNLYAVTKSQAKMVRKLRDSSQSAV...SR..........gPASVPVQCFED................................
M3XN89_MUSPF/152-206                 .......f-HERANIEKTFQDLKEEFHRLCMLAKAQKDHLSKLNV-PATAT...DA...........QCSLPIQCTDK................................
AZI2_HUMAN/213-265                   .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
H2U837_TAKRU/253-306                 ........GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASPV...--...........QRHSPIQHQR-h...............................
G3QIG2_GORGO/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
F6ZSV9_XENTR/194-251                 .......l-CVWQGMEHVFSEMKEEFSQICRLTRKQSLQLNTLLSKKENSP...DIp.........lQCSMPIQCTDE................................
AZI2_BOVIN/214-266                   ......sv--SSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPAAIK-...--...........KACAPAGCMED................................
G3NQ65_GASAC/108-163                 ....sfdy----QDMLNAFEAIQGKFRQIRSLTRRQKDHLKRFHGGSDASS...DQ...........WFSMPIQCTD-r...............................
G3RRH2_GORGO/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
TBKB1_HUMAN/288-342                  ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
H2NVF5_PONAB/312-366                 ........GDDQVNLALAYTELMEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-a...............................
I3KPA6_ORENI/292-352                 ........GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASPV...--...........QLHSPIHHQR-hspvsqrh........................
F7AZG4_ORNAN/150-205                 ........SHERADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLKNETAR...EI...........QFSMPIQCTDK................................
Q4ZG76_HUMAN/99-153                  .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
K9IXQ6_DESRO/132-186                 .......f-HDRSYIEKTFWDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSVPVQCTDK................................
W5KL41_ASTMX/313-369                 ........GDEQVNLALAYTELTEELSRIRSLTAEQSEILRQKRKHPEQKS...PV...........L----------rhsatpqhhsp.....................
U3IJV4_ANAPL/130-185                 ........GHARENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPET...EI...........QFSMPIQCTDK................................
F7DLM0_MONDO/180-234                 .......f-NKREEIEKTFYEMKEEFHRICMLARAQREHLNRLNI-QEPIP...EI...........QFSMPIQCTDE................................
F1LQL4_RAT/226-279                   .......p-HHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGKG...--...........NSCTQVGCVED................................
Q4JQQ1_XENLA/192-249                 .......d-CSRQGIEQIFSEMKEEFSHICRLTRKQSLHLNTFLLKKENSS...EIp.........lQCSMPIQCTDE................................
F7FH52_MONDO/214-266                 ......si--PSDNIHHAYRELKREMSNLHLVTQVQSELLRKFRTPSTIK-...--...........KACAPVQCVED................................
F7DUU2_XENTR/277-330                 ........GDDQVNLALAYTELTEEFYRLRDLTALQSRILRTLLEEQAAFL...G-...........QRHSPPHH---hs..............................
G7MJZ3_MACMU/213-267                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK...G-...........KSCAPVGCSED................................
I3N5U4_SPETR/214-266                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACTPIGYMED................................
H9EZA5_MACMU/288-340                 ........GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSG...G-...........QRHSPLSQR--................................
G3WTC1_SARHA/150-204                 ......fs--KREEIEKIFYEMKEEFRRICMLARAQRDYLNRLNI-QEPIP...EI...........QFSMPIQCTDK................................
H0WQY5_OTOGA/133-187                 .......f-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSRLHI-PDAAT...ET...........QCSLPIQCTDK................................
G3NI57_GASAC/263-317                 ........GDEQVNLALAYTELTEELGRLQALSSKQTEILRKASQEQASPV...-I...........QRHSPIHHQR-h...............................
AZI2_MOUSE/226-278                   .......l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVK-...--...........KACTPVGCVED................................
G1QLY4_NOMLE/16-61                   ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...--...........-----------gem.............................
G7NYA6_MACFA/213-267                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK...G-...........KSCAPVGCSED................................
H3BCD3_LATCH/214-269                 ......ti--RSKFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRATLTAAN...KD...........SLSFPAQCVED................................
H0Z8E4_TAEGU/128-183                 ......sp--ERENLETIFQDMKEECHRICMLAREQTDQLSIFKIKPEPET...EI...........QFSMPIQCTDK................................
G1U0B2_RABIT/209-260                 .......s-ISRDNMQ-VYWELKREMSDLHLMTQVQAERLRKLKMPTAFK-...--...........KACAPLTCAED................................
W5UJD7_ICTPU/128-184                 kiedvldt----------LQDIQGTFQRIQTLARRQKDHLKRIHKGNDTASvsaEK...........QFSMPIQCTDD................................
H0WT23_OTOGA/214-266                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTSIK-...--...........KACAPGGCFED................................
H0VSY8_CAVPO/154-206                 .......f---RDNLEKTFWDLKEEFHRICVLAKAQKDHLSKLNI-PDVAT...ET...........QCSVPIQCTDK................................
D2H3M5_AILME/214-266                 .......s-ISSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPTTVK-...--...........KACAPVGCMED................................
Q8C2D3_MOUSE/130-184                 .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
F6WYF7_CALJA/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACAPVGCSED................................
G5GM29_9FIRM/43-80                   ......ri---------VFVELKQECGRLTRLQKVQQEQLTRLKVPVA---...--...........-----------tlygi...........................
W5PYW5_SHEEP/214-266                 ......sv--SSDNMQSTYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACAPAGCMED................................
Q4R5I0_MACFA/132-186                 .......l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
U3JPD5_FICAL/128-183                 .......q-HYRENLETIFQEMKEECHRICMLAREQTDQLSIFKIKPEPET...EI...........EFSMPIQCTDK................................
TBKB1_MOUSE/289-343                  ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNA...G-...........QRHSPLSQRH-s...............................
I3J5Z3_ORENI/291-334                 ........GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPAVK-...--...........-----------ll..............................
G3X1J5_SARHA/287-341                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQAQRS...G-...........QRHSPLSQRH-t...............................
L8IJL2_9CETA/164-218                 .......f-HERSYIEKTFRDLKEEFHRICLLAKAQKDHLSKLNV-PTAAP...ET...........QCSMPIQCTDK................................
V9KT79_CALMI/222-276                 ......lr---EVGLQKAYQELKKEMSNVRMVAKVQAELLQKLLATQGSTK...NA...........LLHGPVQCLDD................................
W5KRN8_ASTMX/130-185                 ...gmkge-----DVLDALQEIQGTFQRIQTLARRQKDHLKKIHKGNDAAN...EQ...........QFSMPIQCTDD................................
S7Q2D8_MYOBR/213-265                 .......s-ISSDDVQNVYWELKREMSNLHLVTQVQVELLRKLKTPTAIK-...--...........KACAPVGFMED................................
F6SY96_MOUSE/1-51                    .......x----DNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKK...D-...........SS---------sagrhrqe........................
K9IK54_DESRO/214-266                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACAPVGCVED................................
W5PA13_SHEEP/168-222                 .......f-HERSYIEKTFWDLKEEFHRICLLAKAQKDHLSKLNV-PTTAT...ET...........QCSMPIQCTDK................................
L5L4J0_PTEAL/214-266                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACTPVRCMED................................
W5MQ08_LEPOC/138-193                 .......d-DKSKEILEAFQEIQGKFHVIQNLTRKQKDHLNKLCRANDTAQ...EQ...........QFSMPIQCTD-v...............................
H3DHU3_TETNG/247-291                 ........GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQDQAS--...--...........-----------pasl............................
H2U838_TAKRU/249-302                 ........GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASPV...--...........QRHSPIQHQR-h...............................
U3K3G7_FICAL/216-270                 ....rqdi----QSVQQAYWDLKREMSNLCVVTVKQAEVLRKLKRSPPGAK...KA...........ACTAPVQCVD-................................
H2QDA4_PANTR/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
M3YV01_MUSPF/287-332                 ........GDDQVNLALAYTELTEELGRLRELSALQGRILRTLLQEQARSG...--...........-----------gem.............................
F7GD69_MACMU/213-267                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK...G-...........KSCAPVGCSED................................
G5BT21_HETGA/68-122                  .......i-HERDNLEKTFWGLKEEFHRVCMLAKAQKDHLSKLNI-RDTAT...ET...........QCSMLVQCTDK................................
M3YKM1_MUSPF/250-302                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTTIK-...--...........KACAPVGCMED................................
K7F8Z7_PELSI/146-201                 .......v-HEREDLEMVFQDMKEECHRICTLARKQTDQLSKLNIKREPVN...EI...........QCSMPIQCTDK................................
A2AR76_MOUSE/164-218                 .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
L8J117_9CETA/214-265                 ......sv--SSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPAAIK-...--...........-KCAPAGCMED................................
D3DTT5_HUMAN/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
H0YZD3_TAEGU/222-275                 .......f-----HLQQTYWDLKREMSNLRVVTDKQAEILQKLKRNPLGTK...KGc........qsACTAPVQCVD-................................
W5PEZ8_SHEEP/287-341                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
F7G3B1_MACMU/132-186                 .......l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
W5N737_LEPOC/281-328                 ........GDEQVNLALAYTELTEELCRLQTLCTRQTEILRRVSQEQSSP-...--...........-----------espnhl..........................
Q4SCJ8_TETNG/50-104                  ........GDEQVNLALAYTELTEELGRVRDLAIKQSDLLRQGSQEPVPR-...--...........-----------shpapqrlsptss...................
E1BU10_CHICK/218-271                 ....qavq-----SVQQAYWELKREMSNLQLVTEVQTEVLRKLKTNITATK...KA...........ASSAPVQCVE-................................
H0XPA9_OTOGA/228-279                 .....fsi----DNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTSIK-...--...........KACAPGGCFED................................
D3Z7S3_MOUSE/79-131                  .......l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVK-...--...........KACTPVGCVED................................
I3LKX7_PIG/213-265                   ......st--SSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KAGTPAGYTED................................
E7ENY2_HUMAN/133-187                 .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
Q8VDA2_RAT/131-185                   .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
G3T829_LOXAF/102-156                 .......f-HERDYIEKTFWDLKEEFHRICMLAKAQKEHLSKLNV-PDTAT...ET...........QCSVPVQCTDK................................
U6E0Z0_NEOVI/103-157                 ........GDDQVNLALAYTELTEELGRLRELSALQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
H7C1Z1_HUMAN/11-61                   .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK...--...........-----------alsqnram........................
G1KG46_ANOCA/281-342                 ........GDDQVNLALAYTELTEELCRLRNLSSLQSQILRTLMQEQTISG...G-...........QRHSPHSQRH-spaqqrrs........................
B2R7S3_HUMAN/132-186                 .......l-HERGNIEKAFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
G9KSD5_MUSPF/63-117                  .......f-HERANIEKTFQDLKEEFHRLCMLAKAQKDHLSKLNV-PATAT...DA...........QCSLPIQCTDK................................
I3J5Z4_ORENI/291-334                 ........GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPAVK-...--...........-----------ll..............................
U6CZ11_NEOVI/1-52                    .......r----ASIEKTFQDLKEEFHRLCMLAKAQKDHLSKLNV-PAPAT...EA...........QCSLPIQCTDK................................
G1NF49_MELGA/235-279                 ......fe-----SVQQAYWELKREMSNLQLVTEVQTEVLRKLKTNITATK...--...........-----------kgksv...........................
F7GD78_MACMU/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
L5MH72_MYODS/304-343                 .......s-ISSDDVQNVYWELKREMSNLHLVTIT----------------...--...........-----------raqctnsctlkgt...................
I3J5Z2_ORENI/291-334                 ........GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPAVK-...--...........-----------ll..............................
Q6NW12_HUMAN/132-186                 .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
H2U839_TAKRU/251-304                 ........GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASPV...--...........QRHSPIQHQR-h...............................
F1M101_RAT/131-185                   .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
Q08CI3_DANRE/126-180                 ......em--KSEDVLDTWQELQGTFQRIQSLTRRQKDHLKRIHKGNDTAN...E-...........QFSMPIQCTD-g...............................
H2P7M8_PONAB/131-185                 .......l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
H0Y0C3_OTOGA/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNG...G-...........QRHSPLSQRH-s...............................
M7BH81_CHEMY/197-258                 ....kssg----ENVQQAYWELKREMSNLHLVTEVQAEVLRKLKTPTATKK...GNcll.....spaSTCAPVQCVED................................
AZI2_PONAB/213-265                   .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
E1C5I0_CHICK/190-245                 ......lp--ERENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPET...EI...........QFSMPIQCTDK................................
K7G4G0_PELSI/79-128                  ........GDDQVNLALAYTELTEELCRLRSLSSLQSQILRTLLQEQALNG...GE...........-----------hrarp...........................
H2QM81_PANTR/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
Q8R383_MOUSE/130-184                 .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
H2TA08_TAKRU/262-307                 ........GDEQVNLALAYTELTEELGRVRGLAITQSDLLRQVSQEPG---...--...........-----------rschfv..........................
W5M313_LEPOC/228-282                 .....vda-----SLLKTYVDLRREMSNLYAVTKSQAKMVRKLRDSSQSAV...SR..........gPASVPVQCFED................................
M3ZAV8_NOMLE/243-295                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
S7N9N1_MYOBR/101-153                 .......s-ISSDDVQNAYCELKREMSNLHLVTQVQVELLRKLKTPTVIK-...--...........KACAPVGFME-n...............................
B7ZS21_XENLA/192-249                 .......d-CSRQGIEQIFSEMKEEFSHICRLTRKQSLHLNTFLLKKENSS...EIp.........lQCSMPIQCTDE................................
U3D3M6_CALJA/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
Q4RNN8_TETNG/363-416                 ......ss--KRVNLALAYTELTEELGRLQALSTKQTEILRKASQDQASPV...--...........QRHSPIHHQR-h...............................
M3WDK4_FELCA/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
S3NAH1_9GAMM/221-261                 ...qfekn--------KIFTELKSEISELQNSTQTQIQQLNTTLQQQAE--...--...........-----------sfl.............................
Q3UGW0_MOUSE/131-185                 .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
G1LDC5_AILME/307-359                 ........GDDQVNLALAYTELTEELGRLRETPLLPTTVLPSTRLASLPG-...--...........QRHSPLSQRH-s...............................
Q3TNB4_MOUSE/130-184                 .......h-HERNNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
K9K446_HORSE/203-255                 .......t-ISSDNMQNAYWELRREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KAYIPVGCMED................................
H2QIV9_PANTR/132-186                 .......l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
H0Z8D8_TAEGU/66-121                  ......na--NRENLETIFQDMKEECHRICMLAREQTDQLSIFKIKPEPET...EI...........QFSMPIQCTDK................................
F7A092_MOUSE/153-197                 .......l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKK...--...........-----------gh..............................
G1TNR4_RABIT/132-186                 .......f-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNIPDTVI-...ET...........QCSVPIQCTDK................................
G1NEX6_MELGA/130-185                 ......lp--ERENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPET...EI...........QFSMPIQCTDK................................
M3ZC42_NOMLE/190-244                 .......l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
H3BD49_LATCH/291-345                 ........GDEQVNLALAYTELTEELCRLRSVSTTQSEILRKLLQGQTHA-...--...........HAH--------aeiterspmq......................
TANK_HUMAN/132-186                   .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
#=GR TANK_HUMAN/132-186        SS    .......X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX...XX...........XX---B--TTS................................
G1QVJ4_NOMLE/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
E2RLT7_CANFA/214-266                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKIPTTIK-...--...........KACSPVGCMED................................
G3SNE1_LOXAF/288-341                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQTRSG...G-...........QRHSPLSQR--p...............................
L5LRP8_MYODS/132-186                 .......f-HERSYIEKTFWDLKEEFHRICMLAKAQKDHLSKLNVSATAA-...GT...........QCSVPIQCTDK................................
F6R2Z7_BOVIN/132-186                 .......f-HERSYIEKTFRDLKEEFHRICLLAKAQKDHLSKLNVPSAAP-...ET...........QCSMPIQCTDK................................
E7FAL4_DANRE/126-171                 ......em--KSENVLDTWQELQGTFQRIQSLTRRQKDHLKRIHKGNDTAN...G-...........-----------kf..............................
H3CZR8_TETNG/256-308                 ........GDEQVNLALAYTELTEELGRVRDLAIKQSDLLRQGSQEPGRA-...--...........-----------kmsdldgrhsp.....................
I3MAC0_SPETR/149-203                 .......f-HERGNIEKTFWDLKEEFHRICILAKAQKDHLSKLNI-PDIAT...ET...........QCSVPIQCTDK................................
G1KPN5_ANOCA/227-282                 .......d-IHSVNVQHAYWELKKEMSNLHLVTEVQAEMLKKLKLIPLGTR...KV...........PSCTPLQCVED................................
I3NBS2_SPETR/230-280                 .......f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACTPIGYMED................................
D2HPY4_AILME/132-186                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPIQCTDK................................
R0J8K2_ANAPL/1-52                    .......m-----EMDKIFLQLCEEVTRLQDLCAKQGKLLQKLTARKGPVL...DI...........PMSLPVQCTED................................
V9LCQ9_CALMI/209-253                 ......lr---EVGLQKAYQELKKEMSNVRMVAKVQAELLQKLLATQGST-...--...........-----------kngk............................
M3WSX4_FELCA/220-272                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTTVK-...--...........KACAPIGCMED................................
G3NPU7_GASAC/259-304                 ........GDEQVNLALAYTELTEELGRVRNLAVKQSDLLRHVSQEPGRT-...--...........-----------schr............................
F7AZB3_ORNAN/135-188                 .......f---RADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLKNETAR...EI...........QFSMPIQCTDK................................
F7AQP5_MACMU/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
H0VQS5_CAVPO/214-266                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKASASIK-...--...........KVCTPVGCTED................................
G3X0K7_SARHA/229-279                 .......f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKFKTSSIIK-...--...........KACAPVQCVDD................................
K7GPD1_PIG/131-185                   .......f-HERGYVEKTFWDLKEEFHRIRMLAKAQKDHLSKLNVADTAA-...ET...........QCSVPVQCTDK................................
F6RX86_XENTR/233-277                 ......es-----SMRQAFWELKKEMSNLHLMTEVQGKVLRKLKAAVTASQ...K-...........-----------athv............................
E6ZI15_DICLA/301-351                 ........GDEQVNLALAYTELTEELGRLQALSSKQTEILRKASQEQASPA...EW...........-----------kpskvi..........................
TBKB1_RAT/289-343                    ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNA...G-...........QRHSPLSQRH-s...............................
E7EQA9_HUMAN/132-186                 .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
E6ZI16_DICLA/293-341                 ........GDEQVNLALAYTELTEELGRLQALSSKQTEILRKASQEQASPG...K-...........-----------hlqyt...........................
F6YBK2_CALJA/132-186                 .......l-HERDNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
H0XIS9_OTOGA/205-254                 .......s-ISSDNMQHVYWELKREMSNLHLVTQVQ---LRRLKTPTSIK-...--...........KPCAPGGCIED................................
F7BNJ6_HORSE/132-155                 .......f-HERGYIEKTFCDLKEEFHRICML-------------------...--...........-----------................................
G1PQ89_MYOLU/296-350                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQTRSG...G-...........QRHSPLSQRH-s...............................
G7PKN6_MACFA/132-186                 .......l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
M4AGT4_XIPMA/253-308                 ........GDEQVNLALAYTELTEEVGRLQALCSKQTEILRKAAQEPASP-...--...........-----------elvsarqrhkamaq..................
M1EJC2_MUSPF/276-328                 .......s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTTIK-...--...........KACAPVGCMED................................
G1T8F3_RABIT/214-266                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTTIK-...--...........KAYTPAACTED................................
H2PBA6_PONAB/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
F1PEY1_CANFA/148-202                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPIQCTDK................................
G1QF19_MYOLU/201-245                 .......s-ISSDEMQNAYWELKGEMSNLHLVTQVQIEL------------...--...........-----------ktptaikkacapyl..................
A0A024R2K9_HUMAN/213-262             .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK...G-...........N----------lcpcr...........................
V2UHI5_9GAMM/221-261                 ...qfekn--------KIFTELKSEISELQNSTQTQIQQLNTTLQQQAE--...--...........-----------sfl.............................
E7EW82_HUMAN/191-236                 .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTAT-...--...........-----------ahle............................
G7PU58_MACFA/286-337                 ........GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSG...EV...........-----------gtircas.........................
G5B981_HETGA/214-266                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACTPVGCTED................................
M3W2U2_FELCA/132-186                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPVQCTD-t...............................
G9KSM5_MUSPF/12-66                   ........GDDQVNLALAYTELTEELGRLRELSALQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
E7FGU2_DANRE/285-338                 ........GDEQVNLALAYTELTEELGKLQALTSKQTEILRKASQEPASPV...--...........QRHSPVPHQR-h...............................
B7ZS25_XENLA/192-249                 .......d-CSRQGIEQIFSEMKEEFSHICRLTRKQSLHLNTFLLKKENSS...EIp.........lQCSMPIQCTDE................................
H3BCD2_LATCH/215-270                 ......qk--SEEFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRATLTAAN...KD...........SLSFPAQCVED................................
I3KPA7_ORENI/249-297                 ........GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASPE...--...........-----------vshfsf..........................
Q0VD25_BOVIN/164-218                 .......f-HERSYIEKTFRDLKEEFHRICLLAKAQKDHLSKLNVPSAAP-...ET...........QCSMPIQCTDK................................
F6ZGI5_ORNAN/214-266                 .......s-IQSDDMQYAYWELKKEMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KAYAPVQCVED................................
F7IND3_CALJA/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
TANK_MOUSE/165-219                   .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
W5KT29_ASTMX/287-367                 ........GDEQVNLALAYTELTEELGKLQALSAKQTEILRKASQEQASPV...--...........QRHSPV-----plqrhspvpqrhspiqqrhspiqqrhspvpqr
J9P6W5_CANFA/132-186                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPIQCTDK................................
K6ZPU5_PANTR/213-265                 .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
E1BM04_BOVIN/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
G1QMY3_NOMLE/132-186                 .......l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
V9L0P1_CALMI/9-62                    ......yy---REELEMFFQQICQQFKQLSTLTTKQAELLGKSKYSNNTI-...DL...........DFSIPIQCTDE................................
V9KR41_CALMI/180-234                 .....ltn---EEELEMFFQQICQQFKQLSTLTTKQAELLGKSKYSNNTI-...DL...........DFSIPIQCTDE................................
H7C3L4_HUMAN/23-77                   .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPIQCTDK................................
G1NUH1_MYOLU/168-222                 .......f-HERSYIEKTFWDLKEEFHRICMLAKAQKDHLSKLNVS-ATAA...ET...........QCSVPIQCTDK................................
U3CVK9_CALJA/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
E7EVA2_HUMAN/190-235                 .......l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTAT-...--...........-----------ahle............................
I3KPA8_ORENI/257-311                 ........GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASP-...DH...........QRHSPVSQRH-s...............................
I3N9C9_SPETR/230-280                 .......f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KACTPIGYMED................................
V8PA87_OPHHA/195-250                 .......v-CERDELESVFWGMKEEFSRIRALARAQSDQLNKCNLRREPTT...EI...........PFSKPIQCTDE................................
H9GRY7_ANOCA/194-248                 .......y--ERDELESVFWSMKEEFYRIRTLAKAQTDQLSKFNIRREPAT...EI...........PFSKPIQCTDE................................
L8YBM5_TUPCH/1253-1305               ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQDQARSG...GQ...........-----------grgsrqcw........................
H3C5J3_TETNG/121-175                 ......fv---SQDMLDAFEAIQGKFRQLQSLTRRQKDQLKRFRGGNETSS...DQ...........QFSMPIQCTD-r...............................
L5JQA2_PTEAL/287-332                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...--...........-----------gpr.............................
N8YX71_ACIBZ/223-261                 .....ekn--------KIFTELKSEISELQNSTQNQIQQLNTTLQQQAE--...--...........-----------sfl.............................
G1M155_AILME/168-222                 .......f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATAT...ET...........QCSLPIQCTDK................................
G7NH58_MACMU/286-333                 ........GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARS-...--...........-----------girlrf..........................
U3IY28_ANAPL/221-271                 ......es------VQQAYWDLKREMSNLQLVTEVQAEVLRKLKTSSTPTK...KA...........ASSAPVQCVD-................................
F1RWJ4_PIG/288-342                   ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
G5BT31_HETGA/132-186                 .......i-HERDNLEKTFWDLKEEFHRVCMLAKAQKDHLSKLNI-PDTAT...ET...........QCSVPVQCTDK................................
AZI2_MACFA/213-265                   .......s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK-...--...........KACAPVGCSED................................
F1RPR5_PIG/132-186                   .......f-HERGYVEKTFWDLKEEFHRIRMLAKAQKDHLSKLNVADTAA-...ET...........QCSVPVQCTDK................................
G1TLY1_RABIT/288-342                 ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSC...G-...........QRHSPLSQRH-s...............................
F7E486_HORSE/214-266                 .......t-ISSDNMQNAYWELRREMSNLHLVTQVQAELLRKLKTPTAIK-...--...........KAYIPVGCMED................................
K7GMI6_PIG/287-341                   ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSG...G-...........QRHSPLSQRH-s...............................
K7FCI2_PELSI/214-269                 ......nv--QSENVQQAYWELKREMSNLHLVTEVQAEVLRKLKINPTAAK...KA...........STCAPVQCVED................................
AZI2_RAT/226-277                     .......p-HHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGK-...--...........-ACTQVGCVED................................
H2SKW7_TAKRU/123-177                 ......vv---SQDMLDAFEAIQGKFRQIQSLTRRQKDQLKRFRGGNETSN...DQ...........RFSMPIQCTD-r...............................
R0JXY3_ANAPL/235-296                 ......es------VQQAYWDLKREMSNLQLVTEVQAEVLRKLKTSSTPTK...KGksvtdltntdpASSAPVQCVD-................................
G3H5V0_CRIGR/1793-1838               ........GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARN-...--...........-----------aana............................
G1M217_AILME/226-278                 ....khfc----DNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPTTVK-...--...........KACAPVGCMED................................
G1NSE3_MYOLU/225-277                 ......iq--QSDDVQNVYWELKREMSNLHLVTQVQVELLRKLKTPTAIK-...--...........KACAPVGFMED................................
L5K2B2_PTEAL/132-186                 .......f-HESSYIEKTFWDLKEEFHRIRMLAKAQKDHLSKLNV-PATAN...ET...........QCSMPIQCTDK................................
A2AR78_MOUSE/130-184                 .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
A1L1J0_RAT/130-184                   .......h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIAT...DT...........QCSVPIQCTDK................................
F1P609_CANFA/288-336                 ........GDDQVNLALAYTELTEELRRVRLTKACP-----TLGQ-RAGS-...EG...........QRHSPLSQRH-s...............................
#=GC SS_cons                         .......X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX...XX...........XX---B--TTS................................
#=GC seq_cons                        ..........cpsNlppsahELKEEhu+lphLopsQs-hLpKLpttsshs....t............ptshPlpCp-.................................
//
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