GenomeNet

Database: Pfam
Entry: TBD
LinkDB: TBD
Original site: TBD 
#=GF ID   TBD
#=GF AC   PF12845.4
#=GF DE   TBD domain
#=GF AU   Bateman A, Masci AM
#=GF SE   [1]
#=GF GA   21.40 21.40;
#=GF TC   23.80 23.70;
#=GF NC   20.70 18.50;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17568778
#=GF RT   SINTBAD, a novel component of innate antiviral immunity, shares
#=GF RT   a TBK1-binding domain with NAP1 and TANK.
#=GF RA   Ryzhakov G, Randow F;
#=GF RL   EMBO J. 2007;26:3180-3190.
#=GF DR   INTERPRO; IPR024581;
#=GF CC   The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain
#=GF CC   able to bind kinases, has been found to be essential for
#=GF CC   poly(I:C)-induced IRF activation [1]. The domain is found in
#=GF CC   SINTBAD, TANK and NAP1 protein. This domain is predicted to form
#=GF CC   an a-helix with residues essential for kinase binding clustering
#=GF CC   on one side [1].
#=GF SQ   177
#=GS Z4YKN2_MOUSE/288-342        AC Z4YKN2.1
#=GS M4AAF2_XIPMA/110-165        AC M4AAF2.1
#=GS E2RLY7_CANFA/168-222        AC E2RLY7.2
#=GS H2M9R1_ORYLA/267-324        AC H2M9R1.1
#=GS G3QIP7_GORGO/147-201        AC G3QIP7.1
#=GS W5M2Z8_LEPOC/215-268        AC W5M2Z8.1
#=GS M3XN89_MUSPF/152-206        AC M3XN89.1
#=GS AZI2_HUMAN/213-265          AC Q9H6S1.1
#=GS H2U837_TAKRU/253-306        AC H2U837.1
#=GS G3QIG2_GORGO/288-342        AC G3QIG2.1
#=GS F6ZSV9_XENTR/194-251        AC F6ZSV9.1
#=GS AZI2_BOVIN/214-266          AC Q3SYW5.1
#=GS G3NQ65_GASAC/108-163        AC G3NQ65.1
#=GS G3RRH2_GORGO/213-265        AC G3RRH2.1
#=GS TBKB1_HUMAN/288-342         AC A7MCY6.1
#=GS H2NVF5_PONAB/312-366        AC H2NVF5.1
#=GS M3YV01_MUSPF/287-331        AC M3YV01.1
#=GS F7AZG4_ORNAN/150-205        AC F7AZG4.1
#=GS W5KL41_ASTMX/313-369        AC W5KL41.1
#=GS U3IJV4_ANAPL/130-185        AC U3IJV4.1
#=GS F6SY96_MOUSE/1-45           AC F6SY96.1
#=GS F7DLM0_MONDO/180-234        AC F7DLM0.2
#=GS F7FH52_MONDO/214-266        AC F7FH52.2
#=GS I3N5U4_SPETR/214-266        AC I3N5U4.1
#=GS G3WTC1_SARHA/150-204        AC G3WTC1.1
#=GS H0WQY5_OTOGA/133-187        AC H0WQY5.1
#=GS G3NI57_GASAC/263-317        AC G3NI57.1
#=GS AZI2_MOUSE/226-278          AC Q9QYP6.1
#=GS L5MH72_MYODS/304-344        AC L5MH72.1
#=GS G1QLY4_NOMLE/16-61          AC G1QLY4.1
#=GS G7NYA6_MACFA/213-267        AC G7NYA6.1
#=GS H3BCD3_LATCH/214-269        AC H3BCD3.1
#=GS H0Z8E4_TAEGU/128-183        AC H0Z8E4.1
#=GS G1U0B2_RABIT/209-260        AC G1U0B2.1
#=GS H0WT23_OTOGA/214-266        AC H0WT23.1
#=GS H0VSY8_CAVPO/154-206        AC H0VSY8.1
#=GS Q8C2D3_MOUSE/130-184        AC Q8C2D3.1
#=GS F6WYF7_CALJA/213-265        AC F6WYF7.1
#=GS W5PYW5_SHEEP/214-266        AC W5PYW5.1
#=GS U3JPD5_FICAL/128-183        AC U3JPD5.1
#=GS TBKB1_MOUSE/289-343         AC A2A9T0.1
#=GS G3X1J5_SARHA/287-341        AC G3X1J5.1
#=GS M4AGT4_XIPMA/253-304        AC M4AGT4.1
#=GS W5KRN8_ASTMX/130-185        AC W5KRN8.1
#=GS W5PA13_SHEEP/168-222        AC W5PA13.1
#=GS L5L4J0_PTEAL/214-266        AC L5L4J0.1
#=GS W5MQ08_LEPOC/138-193        AC W5MQ08.1
#=GS H3DHU3_TETNG/247-291        AC H3DHU3.1
#=GS A0A096M6V8_POEFO/124-178    AC A0A096M6V8.1
#=GS U3IY28_ANAPL/221-272        AC U3IY28.1
#=GS A0A0D9S3L4_CHLSB/288-342    AC A0A0D9S3L4.1
#=GS H2U838_TAKRU/249-302        AC H2U838.1
#=GS U3K3G7_FICAL/216-270        AC U3K3G7.1
#=GS H2QDA4_PANTR/288-342        AC H2QDA4.1
#=GS H3BD49_LATCH/291-347        AC H3BD49.1
#=GS F7GD69_MACMU/213-267        AC F7GD69.1
#=GS G5BT21_HETGA/68-122         AC G5BT21.1
#=GS A0A0D9RT21_CHLSB/132-186    AC A0A0D9RT21.1
#=GS M3YKM1_MUSPF/250-302        AC M3YKM1.1
#=GS A0A087YJ97_POEFO/294-362    AC A0A087YJ97.2
#=GS A2AR76_MOUSE/164-218        AC A2AR76.1
#=GS H0YZD3_TAEGU/222-275        AC H0YZD3.1
#=GS W5PEZ8_SHEEP/287-341        AC W5PEZ8.1
#=GS F7G3B1_MACMU/132-186        AC F7G3B1.1
#=GS W5N737_LEPOC/281-328        AC W5N737.1
#=GS E1BU10_CHICK/218-271        AC E1BU10.2
#=GS H0XPA9_OTOGA/228-279        AC H0XPA9.1
#=GS D3Z7S3_MOUSE/79-131         AC D3Z7S3.1
#=GS I3LKX7_PIG/213-265          AC I3LKX7.1
#=GS E7ENY2_HUMAN/133-187        AC E7ENY2.1
#=GS G3T829_LOXAF/102-156        AC G3T829.1
#=GS G1KG46_ANOCA/281-342        AC G1KG46.1
#=GS G1NF49_MELGA/235-279        AC G1NF49.1
#=GS F7GD78_MACMU/213-265        AC F7GD78.1
#=GS H2U839_TAKRU/251-304        AC H2U839.1
#=GS H2P7M8_PONAB/131-185        AC H2P7M8.1
#=GS A0A096MTH8_PAPAN/132-186    AC A0A096MTH8.1
#=GS H0Y0C3_OTOGA/288-342        AC H0Y0C3.1
#=GS M7BH81_CHEMY/197-258        AC M7BH81.1
#=GS AZI2_PONAB/213-265          AC Q5RD40.1
#=GS E1C5I0_CHICK/190-245        AC E1C5I0.2
#=GS H2QM81_PANTR/213-265        AC H2QM81.1
#=GS L8YBM5_TUPCH/1253-1307      AC L8YBM5.1
#=GS A0A091DUZ9_FUKDA/1214-1266  AC A0A091DUZ9.1
#=GS A0A096P535_PAPAN/288-342    AC A0A096P535.1
#=GS M3ZAV8_NOMLE/243-295        AC M3ZAV8.1
#=GS W5M313_LEPOC/228-282        AC W5M313.1
#=GS A0A0D9RBD0_CHLSB/213-265    AC A0A0D9RBD0.1
#=GS H9GRY7_ANOCA/193-248        AC H9GRY7.2
#=GS A0A091CX19_FUKDA/147-201    AC A0A091CX19.1
#=GS I3J5Z4_ORENI/291-333        AC I3J5Z4.1
#=GS M3WDK4_FELCA/288-342        AC M3WDK4.1
#=GS G3H5V0_CRIGR/1793-1837      AC G3H5V0.1
#=GS F7DUU2_XENTR/277-329        AC F7DUU2.1
#=GS I3KPA6_ORENI/292-376        AC I3KPA6.1
#=GS G1LDC5_AILME/307-359        AC G1LDC5.1
#=GS H2QIV9_PANTR/132-186        AC H2QIV9.1
#=GS H0Z8D8_TAEGU/66-121         AC H0Z8D8.1
#=GS F7A092_MOUSE/153-197        AC F7A092.1
#=GS G1TNR4_RABIT/132-186        AC G1TNR4.1
#=GS M3ZC42_NOMLE/190-244        AC M3ZC42.1
#=GS TANK_HUMAN/132-186          AC Q92844.2
#=GS G1NEX6_MELGA/130-185        AC G1NEX6.1
#=GS G1QVJ4_NOMLE/213-265        AC G1QVJ4.1
#=GS E2RLT7_CANFA/214-266        AC E2RLT7.2
#=GS G3SNE1_LOXAF/288-341        AC G3SNE1.1
#=GS L5LRP8_MYODS/132-186        AC L5LRP8.1
#=GS F6R2Z7_BOVIN/132-186        AC F6R2Z7.1
#=GS E7FAL4_DANRE/126-171        AC E7FAL4.1
#=GS H3CZR8_TETNG/256-308        AC H3CZR8.1
#=GS I3MAC0_SPETR/149-203        AC I3MAC0.1
#=GS G1KPN5_ANOCA/227-282        AC G1KPN5.2
#=GS I3NBS2_SPETR/230-280        AC I3NBS2.1
#=GS I3J5Z3_ORENI/291-333        AC I3J5Z3.1
#=GS H2TA08_TAKRU/262-306        AC H2TA08.1
#=GS M3WSX4_FELCA/220-272        AC M3WSX4.1
#=GS G3NPU7_GASAC/259-304        AC G3NPU7.1
#=GS F7AZB3_ORNAN/135-188        AC F7AZB3.1
#=GS F7AQP5_MACMU/288-342        AC F7AQP5.1
#=GS H0VQS5_CAVPO/214-266        AC H0VQS5.1
#=GS G3X0K7_SARHA/229-279        AC G3X0K7.1
#=GS K7GPD1_PIG/131-185          AC K7GPD1.1
#=GS F6RX86_XENTR/233-277        AC F6RX86.1
#=GS A0A096MYZ7_PAPAN/213-265    AC A0A096MYZ7.1
#=GS TBKB1_RAT/289-343           AC Q6DG50.1
#=GS E7EQA9_HUMAN/132-186        AC E7EQA9.1
#=GS F1M101_RAT/130-184          AC F1M101.3
#=GS F6YBK2_CALJA/132-186        AC F6YBK2.1
#=GS H0XIS9_OTOGA/205-254        AC H0XIS9.1
#=GS W5KT29_ASTMX/287-364        AC W5KT29.1
#=GS F7BNJ6_HORSE/132-155        AC F7BNJ6.1
#=GS G1PQ89_MYOLU/296-350        AC G1PQ89.1
#=GS G7PKN6_MACFA/132-186        AC G7PKN6.1
#=GS G1T8F3_RABIT/214-266        AC G1T8F3.1
#=GS F1PEY1_CANFA/148-202        AC F1PEY1.2
#=GS H2PBA6_PONAB/213-265        AC H2PBA6.2
#=GS E7EW82_HUMAN/191-236        AC E7EW82.1
#=GS G7PU58_MACFA/286-337        AC G7PU58.1
#=GS G5B981_HETGA/214-266        AC G5B981.1
#=GS M3W2U2_FELCA/132-186        AC M3W2U2.1
#=GS E7FGU2_DANRE/285-338        AC E7FGU2.1
#=GS H3BCD2_LATCH/215-270        AC H3BCD2.1
#=GS I3KPA7_ORENI/249-297        AC I3KPA7.1
#=GS A0A091D8A1_FUKDA/263-315    AC A0A091D8A1.1
#=GS F6ZGI5_ORNAN/214-266        AC F6ZGI5.1
#=GS F7IND3_CALJA/288-342        AC F7IND3.1
#=GS TANK_MOUSE/165-219          AC P70347.1
#=GS J9P6W5_CANFA/132-186        AC J9P6W5.1
#=GS E1BM04_BOVIN/288-342        AC E1BM04.1
#=GS G1QMY3_NOMLE/132-186        AC G1QMY3.1
#=GS G1QF19_MYOLU/201-244        AC G1QF19.1
#=GS H7C3L4_HUMAN/23-77          AC H7C3L4.1
#=GS G1NUH1_MYOLU/168-222        AC G1NUH1.1
#=GS G1M217_AILME/227-278        AC G1M217.1
#=GS F1LQL4_RAT/226-277          AC F1LQL4.3
#=GS E7EVA2_HUMAN/190-235        AC E7EVA2.1
#=GS I3KPA8_ORENI/257-311        AC I3KPA8.1
#=GS I3J5Z2_ORENI/291-333        AC I3J5Z2.1
#=GS I3N9C9_SPETR/230-280        AC I3N9C9.1
#=GS V8PA87_OPHHA/195-250        AC V8PA87.1
#=GS H3C5J3_TETNG/121-175        AC H3C5J3.1
#=GS L5JQA2_PTEAL/287-332        AC L5JQA2.1
#=GS G1M155_AILME/168-222        AC G1M155.1
#=GS F1RWJ4_PIG/288-342          AC F1RWJ4.1
#=GS G5BT31_HETGA/132-186        AC G5BT31.1
#=GS H7C1Z1_HUMAN/11-59          AC H7C1Z1.1
#=GS F1RPR5_PIG/132-186          AC F1RPR5.2
#=GS A0A087YHP4_POEFO/110-165    AC A0A087YHP4.2
#=GS G1TLY1_RABIT/288-342        AC G1TLY1.2
#=GS F7E486_HORSE/214-266        AC F7E486.1
#=GS K7GMI6_PIG/287-341          AC K7GMI6.1
#=GS AZI2_RAT/226-277            AC Q4KMA0.1
#=GS H2SKW7_TAKRU/123-177        AC H2SKW7.1
#=GS G1NSE3_MYOLU/225-277        AC G1NSE3.1
#=GS L5K2B2_PTEAL/132-186        AC L5K2B2.1
#=GS A2AR78_MOUSE/130-184        AC A2AR78.1
#=GS F1P609_CANFA/288-336        AC F1P609.2
Z4YKN2_MOUSE/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAG-......QRHSPLSQRH-s...............................
M4AAF2_XIPMA/110-165                   .ssd---YQDMLAAFEAIQGKFRQIQTLTTKQKHHLKRFHGSYDNSNDQ......RFSMPIQCTD-g...............................
E2RLY7_CANFA/168-222                   ...f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATATET......QCSLPIQCTDK................................
H2M9R1_ORYLA/267-324                   ....GDEQVNLALAYTELTEELGRLRALSAKQTEILRKATQEQASPGG-......-----------ehkhplrfntptqq..................
G3QIP7_GORGO/147-201                   ...l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
W5M2Z8_LEPOC/215-268                   .das------LLKTYVDLRREMSNLYAVTKSQAKMVRKLRDSSQSAVSR.....gPASVPVQCFED................................
M3XN89_MUSPF/152-206                   ...f-HERANIEKTFQDLKEEFHRLCMLAKAQKDHLSKLNV-PATATDA......QCSLPIQCTDK................................
AZI2_HUMAN/213-265                     ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
H2U837_TAKRU/253-306                   ....GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASP--V......QRHSPIQHQR-h...............................
G3QIG2_GORGO/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
F6ZSV9_XENTR/194-251                   ...l-CVWQGMEHVFSEMKEEFSQICRLTRKQSLQLNTLLSKKENSPDIp....lQCSMPIQCTDE................................
AZI2_BOVIN/214-266                     ..sv--SSDNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPAAIK---......KACAPAGCMED................................
G3NQ65_GASAC/108-163                   sfdy----QDMLNAFEAIQGKFRQIRSLTRRQKDHLKRFHGGSDASSDQ......WFSMPIQCTD-r...............................
G3RRH2_GORGO/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
TBKB1_HUMAN/288-342                    ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
H2NVF5_PONAB/312-366                   ....GDDQVNLALAYTELMEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-a...............................
M3YV01_MUSPF/287-331                   ....GDDQVNLALAYTELTEELGRLRELSALQGRILRTLLQEQARS---......-----------gge.............................
F7AZG4_ORNAN/150-205                   ....SHERADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLKNETAREI......QFSMPIQCTDK................................
W5KL41_ASTMX/313-369                   ....GDEQVNLALAYTELTEELSRIRSLTAEQSEILRQKRKHPEQKSP-......-----------vlrhsatpqhhsp...................
U3IJV4_ANAPL/130-185                   ....GHARENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPETEI......QFSMPIQCTDK................................
F6SY96_MOUSE/1-45                      ...x----DNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKD-......-----------sssa............................
F7DLM0_MONDO/180-234                   ...f-NKREEIEKTFYEMKEEFHRICMLARAQREHLNRLNI-QEPIPEI......QFSMPIQCTDE................................
F7FH52_MONDO/214-266                   ..si--PSDNIHHAYRELKREMSNLHLVTQVQSELLRKFRTPSTIK---......KACAPVQCVED................................
I3N5U4_SPETR/214-266                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACTPIGYMED................................
G3WTC1_SARHA/150-204                   ..fs--KREEIEKIFYEMKEEFRRICMLARAQRDYLNRLNI-QEPIPEI......QFSMPIQCTDK................................
H0WQY5_OTOGA/133-187                   ...f-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSRLHI-PDAATET......QCSLPIQCTDK................................
G3NI57_GASAC/263-317                   ....GDEQVNLALAYTELTEELGRLQALSSKQTEILRKASQEQASPV-I......QRHSPIHHQR-h...............................
AZI2_MOUSE/226-278                     ...l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVK---......KACTPVGCVED................................
L5MH72_MYODS/304-344                   ...s-ISSDDVQNVYWELKREMSNLHLVTITRAQ---------------......-----------ctnsctlkgtv.....................
G1QLY4_NOMLE/16-61                     ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARS---......-----------ggem............................
G7NYA6_MACFA/213-267                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK-G......KSCAPVGCSED................................
H3BCD3_LATCH/214-269                   ..ti--RSKFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRATLTAANKD......SLSFPAQCVED................................
H0Z8E4_TAEGU/128-183                   ..sp--ERENLETIFQDMKEECHRICMLAREQTDQLSIFKIKPEPETEI......QFSMPIQCTDK................................
G1U0B2_RABIT/209-260                   ...s-ISRDNMQ-VYWELKREMSDLHLMTQVQAERLRKLKMPTAFK---......KACAPLTCAED................................
H0WT23_OTOGA/214-266                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTSIK---......KACAPGGCFED................................
H0VSY8_CAVPO/154-206                   ...f---RDNLEKTFWDLKEEFHRICVLAKAQKDHLSKLNI-PDVATET......QCSVPIQCTDK................................
Q8C2D3_MOUSE/130-184                   ...h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIATDT......QCSVPIQCTDK................................
F6WYF7_CALJA/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACAPVGCSED................................
W5PYW5_SHEEP/214-266                   ..sv--SSDNMQSTYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACAPAGCMED................................
U3JPD5_FICAL/128-183                   ...q-HYRENLETIFQEMKEECHRICMLAREQTDQLSIFKIKPEPETEI......EFSMPIQCTDK................................
TBKB1_MOUSE/289-343                    ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAG-......QRHSPLSQRH-s...............................
G3X1J5_SARHA/287-341                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQAQRSG-......QRHSPLSQRH-t...............................
M4AGT4_XIPMA/253-304                   ....GDEQVNLALAYTELTEEVGRLQALCSKQTEILRKAAQEPASP---......-----------elvsarqrhk......................
W5KRN8_ASTMX/130-185                   gmkg----EDVLDALQEIQGTFQRIQTLARRQKDHLKKIHKGNDAANEQ......QFSMPIQCTDD................................
W5PA13_SHEEP/168-222                   ...f-HERSYIEKTFWDLKEEFHRICLLAKAQKDHLSKLNV-PTTATET......QCSMPIQCTDK................................
L5L4J0_PTEAL/214-266                   ...s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACTPVRCMED................................
W5MQ08_LEPOC/138-193                   ...d-DKSKEILEAFQEIQGKFHVIQNLTRKQKDHLNKLCRANDTAQEQ......QFSMPIQCTD-v...............................
H3DHU3_TETNG/247-291                   ....GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQDQASP---......-----------asl.............................
A0A096M6V8_POEFO/124-178               ..gv---SQDMLAAFEAIQGKFRQIQTLTTKQKHHLKRFHGSYDNSNDQ......RFSMPIQCTD-g...............................
U3IY28_ANAPL/221-272                   ..es------VQQAYWDLKREMSNLQLVTEVQAEVLRKLKTSSTPTKKA......ASSAPVQCVD-l...............................
A0A0D9S3L4_CHLSB/288-342               ....GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
H2U838_TAKRU/249-302                   ....GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASP--V......QRHSPIQHQR-h...............................
U3K3G7_FICAL/216-270                   rqdi----QSVQQAYWDLKREMSNLCVVTVKQAEVLRKLKRSPPGAKKA......ACTAPVQCVD-................................
H2QDA4_PANTR/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
H3BD49_LATCH/291-347                   ....GDEQVNLALAYTELTEELCRLRSVSTTQSEILRKLLQGQTHA---......-----------hahaeiterspmqra.................
F7GD69_MACMU/213-267                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKK-G......KSCAPVGCSED................................
G5BT21_HETGA/68-122                    ...i-HERDNLEKTFWGLKEEFHRVCMLAKAQKDHLSKLNI-RDTATET......QCSMLVQCTDK................................
A0A0D9RT21_CHLSB/132-186               ...l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
M3YKM1_MUSPF/250-302                   ...s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTTIK---......KACAPVGCMED................................
A0A087YJ97_POEFO/294-362               ....GDEQVNLALAYTELTEEVGRLQALCSKQTEILRKAAQEPASP--V......QLHSPIHHQR-hspvsqrhspisqrhs................
A2AR76_MOUSE/164-218                   ...h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIATDT......QCSVPIQCTDK................................
H0YZD3_TAEGU/222-275                   ..fh------LQQTYWDLKREMSNLRVVTDKQAEILQKLKRNPLGTKKGc...qsACTAPVQCVD-................................
W5PEZ8_SHEEP/287-341                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
F7G3B1_MACMU/132-186                   ...l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
W5N737_LEPOC/281-328                   ....GDEQVNLALAYTELTEELCRLQTLCTRQTEILRRVSQEQSSP-E-......-----------spnhl...........................
E1BU10_CHICK/218-271                   .qav----QSVQQAYWELKREMSNLQLVTEVQTEVLRKLKTNITATKKA......ASSAPVQCVE-................................
H0XPA9_OTOGA/228-279                   .fsi----DNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTSIK---......KACAPGGCFED................................
D3Z7S3_MOUSE/79-131                    ...l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVK---......KACTPVGCVED................................
I3LKX7_PIG/213-265                     ...s-TSSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KAGTPAGYTED................................
E7ENY2_HUMAN/133-187                   ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
G3T829_LOXAF/102-156                   ...f-HERDYIEKTFWDLKEEFHRICMLAKAQKEHLSKLNV-PDTATET......QCSVPVQCTDK................................
G1KG46_ANOCA/281-342                   ....GDDQVNLALAYTELTEELCRLRNLSSLQSQILRTLMQEQTISGGQrhsphsQRHS-------paqqrrs.........................
G1NF49_MELGA/235-279                   ..fe-----SVQQAYWELKREMSNLQLVTEVQTEVLRKLKTNITATK--......-----------kgksv...........................
F7GD78_MACMU/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
H2U839_TAKRU/251-304                   ....GDEQVNLALAYTELTEELGRLQALSTKQTEILRKASQEQASP--V......QRHSPIQHQR-h...............................
H2P7M8_PONAB/131-185                   ...l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
A0A096MTH8_PAPAN/132-186               ...l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
H0Y0C3_OTOGA/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNGG-......QRHSPLSQRH-s...............................
M7BH81_CHEMY/197-258                   .kss---GENVQQAYWELKREMSNLHLVTEVQAEVLRKLKTPTATKKGNcllspaSTCAPVQCVED................................
AZI2_PONAB/213-265                     ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
E1C5I0_CHICK/190-245                   ..lp--ERENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPETEI......QFSMPIQCTDK................................
H2QM81_PANTR/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
L8YBM5_TUPCH/1253-1307                 ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQDQARSGGQ......-----------grgsrqcwap......................
A0A091DUZ9_FUKDA/1214-1266             ..gn--GWVNLALAYTELTEELGRLRELSSLQGRILRTLLQEHARSGES......P----------aaayapa.........................
A0A096P535_PAPAN/288-342               ....GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
M3ZAV8_NOMLE/243-295                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
W5M313_LEPOC/228-282                   .vda-----SLLKTYVDLRREMSNLYAVTKSQAKMVRKLRDSSQSAVSR.....gPASVPVQCFED................................
A0A0D9RBD0_CHLSB/213-265               ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
H9GRY7_ANOCA/193-248                   ..vy--ERDELESVFWSMKEEFYRIRTLAKAQTDQLSKFNIRREPATEI......PFSKPIQCTDE................................
A0A091CX19_FUKDA/147-201               ...i-HERDNLEKTFWDLKEEFHRVCMLAKAQKDHLSKLNI-PDTATET......QCSVPVQCTDK................................
I3J5Z4_ORENI/291-333                   ....GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPA-----......-----------vkl.............................
M3WDK4_FELCA/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
G3H5V0_CRIGR/1793-1837                 ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARN---......-----------aan.............................
F7DUU2_XENTR/277-329                   ....GDDQVNLALAYTELTEEFYRLRDLTALQSRILRTLLEEQAAFLG-......QRHSP------phhh............................
I3KPA6_ORENI/292-376                   ....GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASP--V......QLHSPIHHQR-hspvsqrhspipqrhspvpppphhspiqqrrs
G1LDC5_AILME/307-359                   ....GDDQVNLALAYTELTEELGRLRETPLLPTTVLPSTRLASLPG---......QRHSPLSQRH-s...............................
H2QIV9_PANTR/132-186                   ...l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
H0Z8D8_TAEGU/66-121                    ..na--NRENLETIFQDMKEECHRICMLAREQTDQLSIFKIKPEPETEI......QFSMPIQCTDK................................
F7A092_MOUSE/153-197                   ...l-HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAV----......-----------kkgh............................
G1TNR4_RABIT/132-186                   ...f-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNIPDTVI-ET......QCSVPIQCTDK................................
M3ZC42_NOMLE/190-244                   ...l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
TANK_HUMAN/132-186                     ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
G1NEX6_MELGA/130-185                   ..lp--ERENLETIFQEMKEECHRICMLAREQTDQLSKFKIKPEPETEI......QFSMPIQCTDK................................
G1QVJ4_NOMLE/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
E2RLT7_CANFA/214-266                   ...s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKIPTTIK---......KACSPVGCMED................................
G3SNE1_LOXAF/288-341                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQTRSGG-......QRHSPLSQR--p...............................
L5LRP8_MYODS/132-186                   ...f-HERSYIEKTFWDLKEEFHRICMLAKAQKDHLSKLNV-SATAAGT......QCSVPIQCTDK................................
F6R2Z7_BOVIN/132-186                   ...f-HERSYIEKTFRDLKEEFHRICLLAKAQKDHLSKLNVPSA-APET......QCSMPIQCTDK................................
E7FAL4_DANRE/126-171                   ..em--KSENVLDTWQELQGTFQRIQSLTRRQKDHLKRIHKGNDTAN--......-----------gkf.............................
H3CZR8_TETNG/256-308                   ....GDEQVNLALAYTELTEELGRVRDLAIKQSDLLRQGSQEPGRA---......-----------kmsdldgrhsp.....................
I3MAC0_SPETR/149-203                   ...f-HERGNIEKTFWDLKEEFHRICILAKAQKDHLSKLNI-PDIATET......QCSVPIQCTDK................................
G1KPN5_ANOCA/227-282                   ...d-IHSVNVQHAYWELKKEMSNLHLVTEVQAEMLKKLKLIPLGTRKV......PSCTPLQCVED................................
I3NBS2_SPETR/230-280                   ...f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACTPIGYMED................................
I3J5Z3_ORENI/291-333                   ....GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPA-----......-----------vkl.............................
H2TA08_TAKRU/262-306                   ....GDEQVNLALAYTELTEELGRVRGLAITQSDLLRQVSQEPGR----......-----------schf............................
M3WSX4_FELCA/220-272                   ...s-ISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKTPTTVK---......KACAPIGCMED................................
G3NPU7_GASAC/259-304                   ....GDEQVNLALAYTELTEELGRVRNLAVKQSDLLRHVSQEPGRT---......S----------chr.............................
F7AZB3_ORNAN/135-188                   ...f---RADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLKNETAREI......QFSMPIQCTDK................................
F7AQP5_MACMU/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
H0VQS5_CAVPO/214-266                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKASASIK---......KVCTPVGCTED................................
G3X0K7_SARHA/229-279                   ...f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKFKTSSIIK---......KACAPVQCVDD................................
K7GPD1_PIG/131-185                     ...f-HERGYVEKTFWDLKEEFHRIRMLAKAQKDHLSKLNVADTAA-ET......QCSVPVQCTDK................................
F6RX86_XENTR/233-277                   ..es-----SMRQAFWELKKEMSNLHLMTEVQGKVLRKLKAAVTASQK-......-----------athv............................
A0A096MYZ7_PAPAN/213-265               ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
TBKB1_RAT/289-343                      ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAG-......QRHSPLSQRH-s...............................
E7EQA9_HUMAN/132-186                   ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
F1M101_RAT/130-184                     ...h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIATDT......QCSVPIQCTDK................................
F6YBK2_CALJA/132-186                   ...l-HERDNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
H0XIS9_OTOGA/205-254                   ...s-ISSDNMQHVYWELKREMSNLHLVTQVQ---LRRLKTPTSIK---......KPCAPGGCIE-d...............................
W5KT29_ASTMX/287-364                   ....GDEQVNLALAYTELTEELGKLQALSAKQTEILRKASQEQASP--V......QRHSPV-----plqrhspvpqrhspiqqrhspiqqrhspv...
F7BNJ6_HORSE/132-155                   ...f-HERGYIEKTFCDLKEEFHRICML---------------------......-----------................................
G1PQ89_MYOLU/296-350                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQTRSGG-......QRHSPLSQRH-s...............................
G7PKN6_MACFA/132-186                   ...l-HERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
G1T8F3_RABIT/214-266                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTTIK---......KAYTPAACTED................................
F1PEY1_CANFA/148-202                   ...f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATATET......QCSLPIQCTDK................................
H2PBA6_PONAB/213-265                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACAPVGCSED................................
E7EW82_HUMAN/191-236                   ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTAT---......-----------ahle............................
G7PU58_MACFA/286-337                   ....GDDQVNLALAYTELTEELGRLRELSSLQGKILRTLLQEQARSGEV......-----------gtircas.........................
G5B981_HETGA/214-266                   ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......KACTPVGCTED................................
M3W2U2_FELCA/132-186                   ...f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATATET......QCSLPVQCTD-t...............................
E7FGU2_DANRE/285-338                   ....GDEQVNLALAYTELTEELGKLQALTSKQTEILRKASQEPASP--V......QRHSPVPHQR-h...............................
H3BCD2_LATCH/215-270                   ..qk--SEEFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRATLTAANKD......SLSFPAQCVED................................
I3KPA7_ORENI/249-297                   ....GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASPEVS......H----------fsf.............................
A0A091D8A1_FUKDA/263-315               ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTTIK---......KACTPVGCTED................................
F6ZGI5_ORNAN/214-266                   ...s-IQSDDMQYAYWELKKEMSNLHLVTQVQAELLRKLKTPTAIK---......KAYAPVQCVED................................
F7IND3_CALJA/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
TANK_MOUSE/165-219                     ...h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIATDT......QCSVPIQCTDK................................
J9P6W5_CANFA/132-186                   ...f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATATET......QCSLPIQCTDK................................
E1BM04_BOVIN/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
G1QMY3_NOMLE/132-186                   ...l-HERGNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
G1QF19_MYOLU/201-244                   ...s-ISSDEMQNAYWELKGEMSNLHLVTQVQIEL--------------......-----------ktptaikkacapy...................
H7C3L4_HUMAN/23-77                     ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNI-PDTATET......QCSVPIQCTDK................................
G1NUH1_MYOLU/168-222                   ...f-HERSYIEKTFWDLKEEFHRICMLAKAQKDHLSKLNV-SATAAET......QCSVPIQCTDK................................
G1M217_AILME/227-278                   .hfc----DNMQSAYWELKREMSNLHLVTQVQAELLRKLKTPTTVK---......KACAPVGCMED................................
F1LQL4_RAT/226-277                     ...p-HHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGK---......-ACTQVGCVED................................
E7EVA2_HUMAN/190-235                   ...l-HERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTAT---......-----------ahle............................
I3KPA8_ORENI/257-311                   ....GDEQVNLALAYTELTEELGRLRALSSKQMEILRKATQEQASP-DH......QRHSPVSQRH-s...............................
I3J5Z2_ORENI/291-333                   ....GDEQVNLALAYTELTEELGHVRCLAAKQSDLLQHVSQEPA-----......-----------vkl.............................
I3N9C9_SPETR/230-280                   ...f---SDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTPTAIK---......KACTPIGYMED................................
V8PA87_OPHHA/195-250                   ...v-CERDELESVFWGMKEEFSRIRALARAQSDQLNKCNLRREPTTEI......PFSKPIQCTDE................................
H3C5J3_TETNG/121-175                   ..fv---SQDMLDAFEAIQGKFRQLQSLTRRQKDQLKRFRGGNETSSDQ......QFSMPIQCTD-r...............................
L5JQA2_PTEAL/287-332                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARS---......-----------ggpr............................
G1M155_AILME/168-222                   ...f-HERAYIEKTFQDLKEEFHRICMLAKAQKDHLSKLNV-PATATET......QCSLPIQCTDK................................
F1RWJ4_PIG/288-342                     ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
G5BT31_HETGA/132-186                   ...i-HERDNLEKTFWDLKEEFHRVCMLAKAQKDHLSKLNI-PDTATET......QCSVPVQCTDK................................
H7C1Z1_HUMAN/11-59                     ...s-ISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---......-----------kalsqnr.........................
F1RPR5_PIG/132-186                     ...f-HERGYVEKTFWDLKEEFHRIRMLAKAQKDHLSKLNVADTAA-ET......QCSVPVQCTDK................................
A0A087YHP4_POEFO/110-165               .ssd---YQDMLAAFEAIQGKFRQIQTLTTKQKHHLKRFHGSYDNSNDQ......RFSMPIQCTD-g...............................
G1TLY1_RABIT/288-342                   ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSCG-......QRHSPLSQRH-s...............................
F7E486_HORSE/214-266                   ...t-ISSDNMQNAYWELRREMSNLHLVTQVQAELLRKLKTPTAIK---......KAYIPVGCMED................................
K7GMI6_PIG/287-341                     ....GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGG-......QRHSPLSQRH-s...............................
AZI2_RAT/226-277                       ...p-HHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGK---......-ACTQVGCVED................................
H2SKW7_TAKRU/123-177                   ..vv---SQDMLDAFEAIQGKFRQIQSLTRRQKDQLKRFRGGNETSNDQ......RFSMPIQCTD-r...............................
G1NSE3_MYOLU/225-277                   ..iq--QSDDVQNVYWELKREMSNLHLVTQVQVELLRKLKTPTAIK---......KACAPVGFMED................................
L5K2B2_PTEAL/132-186                   ...f-HESSYIEKTFWDLKEEFHRIRMLAKAQKDHLSKLNV-PATANET......QCSMPIQCTDK................................
A2AR78_MOUSE/130-184                   ...h-HERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNI-PDIATDT......QCSVPIQCTDK................................
F1P609_CANFA/288-336                   ....GDDQVNLALAYTELTEELRRVRLTKACP-----TLGQ-RAGS-EG......QRHSPLSQRH-s...............................
#=GC seq_cons                          .....pcpsNlppAYhELKEEhu+lphLophQs-hL+KLpttssts.........ptssPltCp-.................................
//
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